[en] We investigated the effects of stem cell factor (SCF) on histamine release (HR) from human bronchoalveolar lavage (BAL) mast cells. BAL cells were recovered from lavage performed in patients undergoing clinical bronchoscopy. SCF (0.02-20 ng/ml), which is by itself a poor secretagogue (mean +/- SEM HR: 3.7 +/- 0.9%; n = 27), strongly enhanced HR induced by anti-IgE in a concentration-related manner. Significant potentiation began at 0.2 ng/ml (30 +/- 10%; p < 0.05; n = 12) and reached a plateau at 2 ng/ml (40 +/- 10%; P < 0.01 at 2 ng/ml and 45 +/- 10%; P < 0.01 at 20 ng/ml; n = 12). In contrast, SCF failed to enhance HR induced by calcium ionophore A23187. Among the BAL cell samples initially unresponsive to anti-IgE (55% of samples), 36% (10/28) were converted to responders if the cells were shortly preincubated with SCF. In 25% of samples (7/27), SCF (20 ng/ml) caused direct HR of 10 +/- 2.1%. The mast cells which released histamine when challenged with SCF also secreted higher levels of histamine in response to anti-IgE and calcium ionophore than those nonresponsive to SCF. While interleukin (IL)-3 and IL-5 (20 ng/ml) were unable to modulate immunologic HR, GM-CSF (20 ng/ml) produced significant potentiation (P < 0.05), which was, however, smaller than that observed with SCF.(ABSTRACT TRUNCATED AT 250 WORDS)
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Louis, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Tilkin, P.
Poncelet, M.; Université de Liège - ULiège > Pneumologie-Allergologie
Corhay, Jean-Louis ; Université de Liège - ULiège > Pneumologie-Allergologie
Mendez, P.
Weber, T.
Radermecker, Maurice ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Regulation of Histamine Release from Human Bronchoalveolar Lavage Mast Cells by Stem Cell Factor in Several Respiratory Diseases
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Bibliography
Agius R, Godfrey R, Holgate S. (1985) Mast cell and histamine content of human bronchoalveolar lavage fluid. Thorax 40:760-767.
Bischoff S, Brunner T, DE Weck A, Dahinden C. (1990) Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists. J Exp Med 172:1577-1582.
Bischoff S, Dahinden C. (1992) C‐kit ligand: a unique potentiator of mediator release by human lung mast cells. J Exp Med 175:237-244.
Bousquet J, Chanez P, Lacoste JY (1990) Eosinophilic inflammation in asthma. New Engl J Med 323:103-109.
Casolaro V, Galeone D, Giacumo A, Sanduzzi A, Milello D, Marone G. (1989) Human basophil/mast cell releasability. V. Functional comparisons of cells obtained from peripheral blood lung parenchyma, and bronchoalveolar lavage in asthmatics. Am Rev Respir Dis 139:1375-1382.
Colombo M, Horowitz E, Botana L (1992) The human recombinant c‐kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE‐dependent mediator release from both skin mast cells and peripheral blood basophils. J Immunol 149:599-608.
DE Paulis A., Ciccarelli A, Cirillo R, DE Crescenzo G, Colombo M, Marone G. (1992) Modulation of human lung mast cell function by the c‐kit receptor ligand. Int Arch Allergy Immunol 99:326-329.
Flint K, Leung K, Hudspith D, Brostoff J, Pearce J, Johnson F. (1985) Bronchoalveolar mast cells in extrinsic asthma: a mechanism for the initiation of antigen specific bronchoconstriction. BMJ 291:923-926.
Flint K, Leung P, Pearce J, Hudspith D, Brostoff J, Johnson F. (1985) Human mast cells recovered by bronchoalveolar lavage: their morphology, histamine release and the effects of sodium cromoglycate. Gin Sci 68:427-432.
Frew A, Chan H., Dryden P, Salari H, Lam S, Chang Yeung M. (1993) Immunologic studies of the mechanisms of occupational asthma caused by red cedar. J Allergy Clin Immunol 92:466-478.
Hirai K, Morita Y, Misaki Y (1988) Modulation of human basophil histamine release by hemopoietic growth factors. J Immunol 141:3958-3964.
Kawakami T, Ignaki N, Takei M (1992) Tyrosine phosphorylation is required for mast cell activation by fcrRI cross‐linking. J Immunol 148:3513-3519.
Kirshenbaum A, Goff J, Kessler S, Mican J, Zsebo K, Metcalfe D. (1992) Effect of IL3 and stem cell factor on the appearance of human basophils and mast cells from CD34+ pluripotent progenitor cells. J Immunol 148:772-777.
Knol E, Mul F, Kuipers T, Verhoeven A, Roos D. (1992) Intracellular events in anti‐IgE non‐releasing human basophils. J Allergy Clin Immunol 90:92-103.
Langley K, Bennett L, Wypych J (1993) Soluble stem cell factor in human serum. Blood 81:656-660.
Maruyama N, Tamura G, Aizawa T (1994) Accumulation of basophils and their chemotactic activity in the airways during natural airway obstruction in asthmatic individuals. Am J Respir Crit Care Med 150:1086-1093.
Nguyen K, Gillis S, Macglashan D. (1990) A comparative study of releasing and non‐releasing human basophils: non‐releasing basophils lack an early component of the signal transduction pathway that follows IgE cross‐linking. J Allergy Clin Immunol 85:1020-1029.
Leung K, Flint K, Brostoff J (1988) Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells. Thorax 43:756-761.
Louis R, Dowlati A, Weber T, Bury T, Corhay J, Radermecker M. (1994) Modulation of immunological histamine release from human lung fragments by stem cell factor, IL3, IL5 and GM‐CSF: comparison with human leukocytes. Int Arch Allergy Immunol 105:18-25.
Louis R, Bury T, Corhay J, Radermecker M. (1994) Effect of acute injection of methyl prednisolone in man on immunological and non‐immunological histamine release from leuco Louis et al. cytes and its potentiation by IL3. Clin Exp Allergy 24:60-65.
Okayama Y, Church M. (1992) IL3 primes and evokes histamine release from human basophils but not mast cells. Int Arch Allergy Immunol 99:343-345.
Pearce F, Flint K, Leung K (1987) Some studies on human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymatic dissociation of whole lung tissue. Int Arch Allergy Appl Immunol 82:507-512.
Robinson D, Durham S, Kay B. (1993) Cytokines in asthma. Thorax 48:845-853.
Schleimer R, Lichtenstein L, Gillepsie E. (1991) Inhibition of basophil histamine release by anti‐inflammatory steroids. Nature 292:454-455.
Siraganian R. (1974) An automated continuous flow system for the exact and fluorometric analysis of histamine. Anal Biochem 57:383-394.
Speer W, Czerwenka K, Mundigler G (1993) Specific activation of human mast cells by the ligand for c‐kit: comparison between lung, uterus and heart mast cells. International Archives of Allergy and Immunology 102:170-175.
Walls A, Roberts J, Godfrey R, Church M, Holgate S. (1990) Histochemical heterogeneity of human mast cells: disease‐related differences in mast cell subsets recovered by bronchoalveolar lavage. Int Arch Allergy Appl Immunol 92:233-241.
Wardlaw A, Cromwell O, Celestino D (1986) Morphological and secretory properties of bronchoalveolar lavage mast cells in respiratory diseases. Clin Allergy 16:163-173.
Zsebo K, Williams D, Geisler E (1990) Stem cell factor (SCF) is encoded at the SI locus of the mouse and is the ligand for the c‐kit tyrosine kinase receptor. Cell 63:213-224.
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