Reference : Pharma-clinics. Le medicament du mois. L'atorvastatine (Lipitor).
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Pharma-clinics. Le medicament du mois. L'atorvastatine (Lipitor).
[fr] Drug clinics. Drug of the month. Atorvastatin (Lipitor)
Scheen, André mailto [Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale >]
Revue Médicale de Liège
CHU de Liège
Yes (verified by ORBi)
[en] Anticholesteremic Agents/administration & dosage/therapeutic use ; Antilipemic Agents/therapeutic use ; Cholesterol, LDL/blood/metabolism ; Diet, Fat-Restricted ; Heptanoic Acids/administration & dosage/therapeutic use ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage/therapeutic use ; Hypercholesterolemia/diet therapy/drug therapy ; Hyperlipidemias/diet therapy/drug therapy ; Liver/metabolism ; Pyrroles/administration & dosage/therapeutic use ; Receptors, LDL/drug effects ; Tablets ; Triglycerides/blood/metabolism
[en] Atorvastatin, commercialized by the pharmaceutical companies Parke-Davis and Pfizer under the trade name Lipitor, is a new statin acting as a potent hypolipidaemic drug. By inhibiting HMG-CoA reductase, the key-enzyme of cellular synthesis of cholesterol, it increases the expression of LDL receptors and promotes the hepatic extraction of circulating LDL. It has a more potent action than other available statins, both on LDL cholesterol and triglyceride levels. Atorvastatin is indicated, after diet failure, in the treatment of primary hypercholesterolaemia or combined hyperlipidaemia. Lipitor is available as tablets of 10 and 20 mg. The usual doses is 10 mg once a day, to be increased up to 20 mg/day if necessary. In rare severe cases, the doses may be increased up to 80 mg/day.

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