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Article (Scientific journals)
Ligands and tracers for PET studies of the 5-HT system--current status.
Crouzel, C.; Guillaume, Marcel; Barre, L. et al.
1992In International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology, 19 (8), p. 857-70
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Keywords :
Animals; Humans; Ligands; Radioligand Assay; Receptors, Serotonin/analysis; Serotonin/metabolism; Tomography, Emission-Computed
Abstract :
[en] The status of the radiochemical development and biological evaluation of radioligands and tracers for PET studies of the serotonergic system is reviewed, indicating those agents with present value and those with future potential. Practical recommendations are given for the preparation of two useful radioligands for PET studies of central 5-HT2 receptors, namely [18F]setoperone and [18F]altanserin. Though, it has not proved possible to recommend tracers or radioligands for the study of other aspects of serotonergic system, prospects for future radiochemical development are indicated, especially for developing radioligands for the 5-HT re-uptake site, and for the 5-HT1 and 5-HT3 receptors.
Disciplines :
Chemistry
Author, co-author :
Crouzel, C.
Guillaume, Marcel ;  Université de Liège - ULiège > Département de physique > Spectroscopie atomique et Physique des atomes froids
Barre, L.
Lemaire, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Pike, V. W.
Language :
English
Title :
Ligands and tracers for PET studies of the 5-HT system--current status.
Publication date :
1992
Journal title :
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
ISSN :
0883-2897
Publisher :
Elsevier, Netherlands
Volume :
19
Issue :
8
Pages :
857-70
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 July 2012

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