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L'etude clinique du mois. L'etude HOPE, un essai clinique bicephale aux resultats contrastes.
Scheen, André
2000In Revue Médicale de Liège, 55 (2), p. 121-4
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Keywords :
Aged; Angiotensin-Converting Enzyme Inhibitors/pharmacology/therapeutic use; Cardiovascular Diseases/prevention & control; Diabetes Complications; Humans; Middle Aged; Ramipril/pharmacology/therapeutic use; Randomized Controlled Trials as Topic; Risk Factors; Treatment Outcome; Vitamin E/pharmacology/therapeutic use
Abstract :
[en] The results of the HOPE ("Heart Outcomes Prevention Evaluation") study, recently published in the New England Journal of Medicine, demonstrated a highly significant cardiovascular protection by an angiotensin converting enzyme inhibitor, ramipril at a dose of 10 mg/day, after a mean follow-up of 4.5 years, but not of vitamin E supplements at a dose of 400 UI/day in high-risk patients (> 55 years old) who had evidence of vascular disease (secondary prevention) or combined diabetes mellitus and another cardiovascular risk factor (primary prevention).
Disciplines :
Pharmacy, pharmacology & toxicology
Cardiovascular & respiratory systems
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
L'etude clinique du mois. L'etude HOPE, un essai clinique bicephale aux resultats contrastes.
Alternative titles :
[fr] Clinical study of the month. The HOPE study, a two-by-two factorial clinical trial with contrasted results
Publication date :
2000
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Hopital de Baviere, Liège, Belgium
Volume :
55
Issue :
2
Pages :
121-4
Peer reviewed :
Peer reviewed
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