Assessment of postprandial hepatic glycogen synthesis from uridine diphosphoglucose kinetics in obese and lean non-diabetic subjects.

Paquot, Nicolas; Schneiter, P.; Scheen, André; Lefebvre, Pierre; Tappy, L.

doi:10.1038/sj.ijo.0801386

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Assessment of postprandial hepatic glycogen synthesis from uridine diphosphoglucose kinetics in obese and lean non-diabetic subjects.

Paquot, Nicolas; Schneiter, P.; Scheen, André et al.

2000 • In International Journal of Obesity, 24 (10), p. 1297-302

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https://hdl.handle.net/2268/12254

DOI
10.1038/sj.ijo.0801386

PubMed
11093291

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Keywords :

Adult; Aged; Blood Glucose/analysis; Fatty Acids, Nonesterified/blood; Female; Glucose Intolerance/complications/metabolism; Humans; Insulin/blood; Insulin Resistance; Liver/metabolism; Liver Glycogen/biosynthesis; Male; Middle Aged; Obesity/complications/metabolism; Postprandial Period; Time Factors; Uridine Diphosphate Glucose/metabolism/pharmacokinetics

Abstract :

[en] BACKGROUND: Obese patients are frequently characterized by insulin resistance and decreased insulin-mediated glycogen synthesis in skeletal muscle. Whether they also have impaired postprandial hepatic glycogen synthesis remains unknown. AIM: To determine whether postprandial hepatic glycogen synthesis is decreased in obese patients compared to lean subjects. METHODS: Lean and obese subjects with impaired glucose tolerance were studied over 4h after ingestion of a glucose load. Hepatic uridine diphosphoglucose kinetics were assessed using 13C-galactose infusion, with monitoring of urinary acetaminophen-glucuronide isotopic enrichment to estimate hepatic glycogen kinetics. RESULTS: Estimated net hepatic glycogen synthesis amounted to 18.6 and 22.6% of the ingested load in lean and obese subjects, respectively. CONCLUSION: Postprandial hepatic glycogen metabolism is not impaired in non-diabetic obese subjects.

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Paquot, Nicolas ; Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques

Schneiter, P.

Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale

Lefebvre, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques

Tappy, L.

Language :

English

Title :

Assessment of postprandial hepatic glycogen synthesis from uridine diphosphoglucose kinetics in obese and lean non-diabetic subjects.

Publication date :

2000

Journal title :

International Journal of Obesity

ISSN :

0307-0565

eISSN :

1476-5497

Publisher :

Nature Publishing Group, London, United Kingdom

Volume :

Issue :

Pages :

1297-302

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 06 May 2009

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