Reference : Coexpression of cytokeratin and vimentin in eutopic endometrium and endometriosis thr...
Scientific journals : Article
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
http://hdl.handle.net/2268/103335
Coexpression of cytokeratin and vimentin in eutopic endometrium and endometriosis throughout the menstrual cycle: evaluation by a computerized method.
English
NISOLLE, Michelle mailto [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
Casanas-Roux, Françoise [ > > ]
Donnez, Jacques [ > > ]
1995
Fertility and Sterility
Elsevier
64
1
69-75
Yes (verified by ORBi)
International
0015-0282
1556-5653
New York
NY
[en] Objectives: To evaluate quantitatively cytokeratin and vimentin staining in glandular and stromal cells of eutopic and ectopic endometrium.

DESIGN:
The investigation of cytokeratin and vimentin was carried out using the new computerized technology of image analysis.

SETTING:
University Hospital, Department of Gynecology.

PATIENTS:
Biopsies were taken from patients undergoing a laparoscopy for infertility (29 endometrial biopsies and 31 biopsies of peritoneal endometriosis). None of them were treated.

RESULTS:
Cyclic variations of cytokeratin and vimentin staining were noted in eutopic endometrium. The cytokeratin and vimentin staining pattern consistently was lower in ectopic endometrium than in eutopic endometrium.

CONCLUSIONS:
Endometriotic epithelial and stromal cells undergo a complex program of differentiation giving them histochemical characteristics similar to those observed in endometrium. Such a concomitant expression of antigenicity indicates their close relationship with their mesodermal müllerian origin.
http://hdl.handle.net/2268/103335

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