Montgomery, J.A. (1981) The development of the nitrosoureas: A study incongener synthesis. In Prestayko, A.W., Crooke, S.T., Baker, L.H., Carter, S.K.and Schein, P.S. (eds), Nitrosoureas: Current Status and New Developments.Academic Press, New York, pp. 3-8
International Agency for Research on Cancer (1987) IARC Monographs onthe Evaluation of Carcinogenic Risks to Humans. Suppl 7. Overall Evaluationsof Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42. IARC, Lyon, pp. 150-152
Ludlum, D.B. and Tong, W.P. (1981) Modification of DNA and RNA bases.In Prestayko, A.W., Crook, S.T., Baker, L.H., Carter, S.K. and Schein, P.S.(eds), Nitrosoureas: Current Status and New Developments. Academic Press, New York, pp. 85-94
Ludlum, D.B. and Tong, W.P. (1985) DNA modification by the nitrosoureas:chemical nature and cellular repair. In Muggia, F.M. (ed.), Experimental andClinical Progress in Cancer Chemotherapy. Martinus Nijhoff, Boston, MA, pp. 141-154
Ludlum, D.B., (1986) Formation of cyclic adducts in nucleic acids by thehaloethylnitrosoureas. In Singer, B. and Bartsch, H. (eds). The Role of CyclicNucleic Acid Adducts in Carcinogenesis and Mutagenesis, IARC ScientificPublications no. 7. IARC, Lyon, pp. 137-146
Ludlum, D.B. (1986) Nature and biological significance of DNA modification by the haloethylnitrosoureas. In Schmael, D. and Bartsch, H. (eds), Carcinogenicity of Alkylating Cytostatic Drugs, IARC Scientific Publicationsno. 78. IARC, Lyon, pp. 71-81
Ludlum, D.B., Kramer, B.S., Wang, J. and Fenselau, C. (1975) Reaction of1, 3-bis(2-chloroethyl)-l-nitrosourea with synthetic polynucleotides.Biochemistry, 14, 5480-5485
Kohn, K.W., Erickson, L.C., Laurent, G., Decore, J., Sharkey, N. and Ewig, R.A. (1981) DNA crosslinking and the origin of sensitivity tochloroethylnitrosoureas. In Prestayko, A.W., Crooke, S.T., Baker, L.H., Carter, S.K. and Schein, P.S. (eds), Nitrosoureas: Current Status and NewDevelopments. Academic Press, New York, pp. 69-83
Erickson, L.C., Laurent, G., Sharkey, N.A. and Kohn, K.W. (1980) DNAcrosslinking and monoadduct repair in nitrosourea-treated human tumor cells.Nature, 288, 727-729
Oesch, F. and Doerjer, G. (1982) Detection of A/2, 3-ethenoguanine in DNAafter treatment with chloroacetaldehyde in vitro. Carcinogenesis, 3, 663-665
Singer, B., Spengler, S.J., Chavez, F. and Kusmierek, J.T. (1987) The vinylchloride-derived nucleoside, /V“.3 et he noguanos me. is a highly efficientmutagen in transcription. Carcinogenesis, 8, 745-747
Wright, G.E. and Dudycz, L.W (1984) Synthesis and characterization ofA, 2-(/)-n-butylphenyl)-2'-deoxyguanosine and its 5'-triphosphate and theirinhibition of HeLa DNA polymerase a. J. Med. Chem., 27, 175-181
Gombar, C.T., Tong, W.P. and Ludlum, D.B. (1980) Mechanism of actionof the nitrosoureas-IV. Reactions of BCNU and CCNU with DNA. Biochem.Pharmacol., 29, 2639-2643
Mehta, J.R. and Ludlum, D.B. (1982) Trapping of DNA-reactive metabolitesof therapeutic or carcinogenic agents by carbon-14-labeled syntheticpolynucleotides. Cancer Res., 42, 2996-2999
Wright, G.E., Dudycz, L.W., Kazimierczuk, Z., Brown, N.C. and Khan, N.N.(1987) Synthesis, cell growth inhibition, and antitumor screening of2-(9-nbutylanilino)purines and their nucleoside analogues. J. Med. Chem., 30, 109-116
Parker, S., Kirk, M.C. and Ludlum, D.B. (1987) Synthesis and characterizationof 06-(2-chloroethyl)guanine: A putative intermediate in the cytotoxic reactionof chloroethylnitrosouieas with DNA. Biochem. Biophys. Res. Common., 148, 1124-1128
Sattsangi, P.D., Leonard, N.J. and Frihart, C.R. (1977) 1.A^-Ethenoguanineand A^, 3-ethenoguanine. Synthesis and comparison of the electronic spectral properties of these linear and angular triheterocycles related to the Y bases. J. Org. Chem., 42, 3292-3296
Tong, W.P., Kirk, M.C. and Ludlum, D.B. (1982) Formation of the crosslink, HA^-deoxycytidyll^-l/V'-deoxyguanosinyll-ethane, in DNA treatedwith /V, A'-bis(2-chloroethyl)-lV-nitrosourea (BCNU). Cancer Res., 42, 3102-3105
Tong, W.P., Kirk, M.C. and Ludlum, D.B. (1983) Mechanism of action ofthe nitrosoureas-V. The formation of 06-(2-fluoroethyl)guanine and itsprobable role in the crosslinking of deoxyribonucleic acid. Biochem.Pharmacol., 32, 2011-2015 (1983)
Maggio, A.-F., Lucas, M., Barascut, J.-L. and Imbach, J.-L. (1986) Formationof a tricyclic nucleoside from deoxyguanosine via an C/'-N -transposition.J. Heterocyclic Chem., 23, 969-970
