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See detailComparison of four methods for the identification of Trichophyton benhamiae strains: Maldi-Tof MS, ITS sequencing, Diversilab® system and DermaGenius® Multiplex Real-Time PCR kit.
SACHELI, Rosalie ULiege; Ferrer Clusella, Aida ULiege; ADJETEY BAHUN, Akolé ULiege et al

Poster (2017, October)

Background: Infections due to the zoophilic dermatophyte Trichophyton benhamiae are being more frequently diagnosed in Belgium since a few years. This species has been recently included in the T ... [more ▼]

Background: Infections due to the zoophilic dermatophyte Trichophyton benhamiae are being more frequently diagnosed in Belgium since a few years. This species has been recently included in the T. benhamiae series together with T. concentricum, T. verrucosum and T. erinacei (De Hoog et al 2016). The strains appear in culture with a bright yellow thallus and do not easily sporulate making them difficult to identify by microscopy. Maldi-Tof MS may present an alternative to microscopic or molecular identification of this species. Molecular methods as ITS sequencing, Rep-PCR by Diversilab® system and realtime PCR by DermaGenius® kit, have been evaluated as identification methods. Methods: A total of 37 strains have been analyzed, all collected by the National Reference Center for mycosis between 2012 and 2016. Strains appearing with a yellow pigment in culture were compared to strains appearing white in culture and presenting characteristics of Trichophyton interdigitale by microscopy. All strains were characterized by Maldi-Tof MS (Bruker), ITS sequencing, rep-PCR (Diversilab® system, bioMérieux) and real-time PCR (DermaGenius® Nail multiplex kit, Pathonostics). Results: Among the 37 strains, ITS sequencing identified 10 T. benhamiae and 27 T. interdigitale. Most of the time, white strains gave rise to T. interdigitale identification while strains with yellow pigmentation were identified as T. benhamiae. However, two strains were identified as T. benhamiae but did not produce clear yellow pigmentation. DermaGenius®kit was able to detect the same 27 white strains previously identified by ITS sequencing as T. interdigitale but nor the 8 strains with yellow pigmentation nor the two white strains identified as T. benhamiae by ITS sequencing could be recognized. This is explained by the lack of specific designed primers and probes included in the kit. The Diversilab® system classified 19 white strains in a unique cluster belonging to T. interdigitale. Six strains producing yellow pigment as well as the two white strains identified as T. benhamiae by ITS sequencing belonged to a single cluster sharing only 75% of similarity with the cluster of T. interdigitale strains. Finally Maldi-Tof MS could identified14 white strains as T. interdigitale, one white strain was identified as T. benhamiae and 4 analyzed strains producing a yellow pigment were identified as T. benhamiae (51,5% of correct identification). T. interdigitale strains and T. benhamiae strains formed two different clusters easily visualized on the dendrogram. Conclusion: ITS sequencing is the method of choice to identify T. benhamiae strains. The DermaGenius® kit is not yet able to detect this emerging species. Improvement of this method is necessary as the number of T. benhamiae isolated in Europe is increasing. Rep-PCR by Diversilab® is a typing method able to classify the strains into two different clusters of strains belonging to T. interdigitale and T. benhamiae, sharing few similarities and justifying the change of classification of T. benhamiae outside the ancient T. mentagrophytes complex. Finally, Maldi-Tof MS in our settings could identify only 50% of T. benhamiae strains and improvement of the extraction method is necessary to increase the method efficiency. [less ▲]

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See detailUn « Massive Open Online Course » (MOOC) sur des travaux pratiques en Histologie : le grand écart entre son intégration dans l’enseignement universitaire et l’intérêt du grand public.
Multon, Sylvie ULiege; Pesesse, Laurence ULiege; Weatherspoon, Alodie et al

Conference (2017, October)

L’acronyme anglophone MOOC désigne les « Massive Open Online Courses » que l’on pourrait traduire par « formations en ligne massives ouvertes à tous ». Nés aux États-Unis avec un programme sur ... [more ▼]

L’acronyme anglophone MOOC désigne les « Massive Open Online Courses » que l’on pourrait traduire par « formations en ligne massives ouvertes à tous ». Nés aux États-Unis avec un programme sur l’intelligence artificielle dispensé par l’université de Stanford, ces cours en ligne accessibles gratuitement font miroiter la possibilité d’une démocratisation maximale des savoirs. A ce titre, les MOOC bénéficient des innovations issues du Web 2.0 : ils tirent le meilleur de la rencontre entre les nouveaux usages induits par les réseaux sociaux et les apports de la pédagogique active. Ces cinq dernières années, nous avons dispensé les travaux pratiques en Histologie aux 500 étudiants de première année d’étude de la faculté de Médecine de l’Université de Liège par une méthodologie hybride alliant e-learning et présentiel (Multon et al., 2015). Forte de cette expérience réussie, notre équipe a réalisé un MOOC faisant partie intégrante du cursus de nos étudiants et qui répond à la volonté de partager nos ressources numériques avec un public plus large. Ce MOOC intitulé « Introduction à l’histologie, exploration des tissus du corps humain » est dédié à l’étude des 5 familles de tissus biologiques. Deux parcours pédagogiques permettent d’approfondir différemment la matière et ainsi de mieux correspondre aux objectifs ou motivations de chacun. La première session, hébergée sur la plate-forme FUN (France Université Numérique), s’est déroulée en 6 semaines à partir de février 2017. Au travers de vidéos explicatives contenant des dessins construits au fur et à mesure et des liens avec l’anatomie suivie d’activités interactives telles que la manipulation d’un microscope virtuel, de nombreux quiz et d’activités réalisées avec les pairs, les participants seront capables de reconnaître les différents types cellulaires et tous les éléments qui les entourent afin de comprendre comment ils s’organisent entre eux pour former des tissus aux fonctions spécifiques. A l’issu de chaque module, les apprenants ont la possibilité de réaliser des activités certificatives. L’obtention de 70% à chacune donne lieu à une attestation de suivi avec succès du MOOC. Notre MOOC a attiré 5250 personnes issues de 82 pays. Un sondage à l’inscription (n=841) indique que 42% sont des étudiants et 41% ont une activité professionnelle. Un forum actif a permis de nombreux échanges entre apprenants ou avec l’équipe pédagogique (170 fils de discussion). De nombreux participants ont souligné les aspects didactique, accessible, dynamique et captivant du MOOC. Nos étudiants ont apprécié la possibilité de travailler où et quand ils le souhaitaient tout en étant guidés par la structure des différents modules. Nos premières données montrent que 32% des apprenants ont utilisé le microscope virtuel et que 20% se sont engagés dans les activités certificatives, la moitié d’entre eux les ayant réussies. En conclusion, la première édition de ce MOOC francophone a intéressé un vaste public. Dix pourcents des participants ont obtenu l’attestation finale, la moyenne se situant généralement autour de 5% pour les autres MOOC (Oliveri, 2016). Un sondage final est actuellement analysé, il nous permettra d’étudier le ressenti des apprenants sur les différentes composantes de l’expérience d’apprentissage. [less ▲]

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See detailAlternative splicing induced by cisplatin : Effect on mitochondria shape
Chakrama, Fatima ULiege; Lambert, Charles ULiege; Gabriel, Maude et al

Poster (2017, October)

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See detailDevelopment of solar energy in Africa : A challenge in terms of resource availability and recycling.
Pirard, Eric ULiege; Belboom, Sandra ULiege

Conference (2017, October)

Focusing on Africa, sun is a renewable resource, free of charge, without any dependency of supply from other countries but implying technologies to transform this resource into electricity. Photovoltaic ... [more ▼]

Focusing on Africa, sun is a renewable resource, free of charge, without any dependency of supply from other countries but implying technologies to transform this resource into electricity. Photovoltaic panels are dedicated to this goal and present several advantages as the free cost of the fuel and no emissions during the production of electricity. These advantages are counterbalanced by the high amount of mineral resources needed, the lifetime of installations, the decreasing yield during operation years and the very limited recycling potential [less ▲]

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See detailImprovement of battery life of iPhones Inertial Measurement Unit by using edge computing Application to cattle behavior
Debauche, Olivier ULiege; Mahmoudi, Saïd; Manneback, Pierre et al

Conference (2017, October)

Smartphones, particularly iPhones, can be relevant instruments for researchers widely used around the world in multiple domains of applications such as animal behavior. iPhones are readily available on ... [more ▼]

Smartphones, particularly iPhones, can be relevant instruments for researchers widely used around the world in multiple domains of applications such as animal behavior. iPhones are readily available on the planet, contain many sensors and require no hardware development. They are equipped with high performance inertial measurement units (IMU) and absolute positioning systems analyzing users movements, but they can easily be diverted to analyze likewise the behaviors of domestic animals such as cattle. Using smartphones to study animal behavior requires the improvement of the autonomy to allow the acquisition of many variables at a high frequency over long periods of time on a large number of individuals for their further processing through various models and decision-making tools. Storing, treating data at the iPhone level with an optimal consumption of energy to maximize battery life was achieved by using edge computing on the iPhone. It reduced the size of the raw data by 42% on average by eliminating redundancies. The decrease in sampling frequency, the selection of the most important variables and postponing calculations to the cloud allowed also an increase in battery life by reducing of amount of data to transmit. [less ▲]

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See detailCYCLOSTRATIGRAPHIC ANALYSIS OF THE LOWER CRETACEOUS TERRESTRIAL SONGLIAO BASIN, NORTHEAST CHINA
Liu, Wei; Wu, Huaichum; Hinnov, Linda et al

in 33 rd INTERNATIONAL MEETING OF SEDIMENTOLOGY, 16ème CONGRÈS FRANÇAIS DE SÉDIMENTOLOGIE (2017, October)

Recent exploration of the Songliao Basin, NE China, which is one of the largest and longlived Cretaceous continental basins in the world with a continuous 10-km-thick sequence of strata, provides new ... [more ▼]

Recent exploration of the Songliao Basin, NE China, which is one of the largest and longlived Cretaceous continental basins in the world with a continuous 10-km-thick sequence of strata, provides new opportunities to study terrestrial climate change and to improve the Early Cretaceous time scale. Understanding the evolution of the basin, including the climatic and environmental changes that affected sediment deposition, is key to identifying the forces that led to enhanced carbon burial and preservation, leading to today’s oil and gas reserves in the basin. In this study, we conduct cyclostratigraphic analysis on natural gamma-ray logs from extended boreholes in the Songliao Basin. The target is the Lower Cretaceous Shahezi Formation (K1S), a 836-m-thick succession with black and dark grey mudstone, siltstone, fine grained sandstone, gravel-bearing sandstone and conglomerate, together with meter-scale black coal units distributed throughout the upper part of the formation. The mudstones have the highest gamma-ray values and the conglomerates the lowest gammaray values. Time series analysis of the gamma-ray logs from selected boreholes reveals power spectra that are consistent with Earth’s astronomical frequencies of precession, obliquity and orbital eccentricity, providing strong evidence for astronomically driven climate change. The results also indicate that black coal coincides with short eccentricity minima that exceed a threshold. We conclude that the age of K1S is from early Valanginian to late Hauterivian with a duration of approximately 11 million years by calculating cycle number and matching with the La2004 theoretical astronomical model. The formation may also reflect the well-known transient cooling Weissert Event in the mid-Valanginian as evidenced by marine glendonites at Svalbard Island. The cyclic evolution of the formation’s lithology indicates a paleo-lake and surrounding environment that expanded and contracted repeatedly. Astronomical forcing influenced paleo-lake level: climate was warm and humid with high orbital eccentricity, and cold and dry with low orbital eccentricity. Sedimentation rates significantly decreased from lower to upper K1 S as the basin evolved from synrift to post-rift conditions. [less ▲]

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See detailPrise en charge tardive d’une intoxication volontaire au méthanol : Efficacité du traitement par 4 méthyl-pyrazole et hémodialyse
DENOOZ, Raphael ULiege; DEVILLE, Marine ULiege; Charlier, Corinne ULiege

Poster (2017, October)

Objectif : Le méthanol est un produit bien connu du grand public pour sa redoutable toxicité en cas d’ingestion. Son accessibilité aisée en vente libre, de même qu’une prise facilitée par l’absence de ... [more ▼]

Objectif : Le méthanol est un produit bien connu du grand public pour sa redoutable toxicité en cas d’ingestion. Son accessibilité aisée en vente libre, de même qu’une prise facilitée par l’absence de saveur désagréable, explique qu’il soit fréquemment utilisé pour les actes d’autolyse. L’examen clinique dans les heures suivant la prise est souvent peu spécifique, et similaire à celui d’une intoxication éthylique. Les signes évocateurs d’une intoxication sont principalement biologiques, à savoir une acidose métabolique associée à un trou anionique augmenté, expliquée par la production d’acide formique, le principal métabolite. La confirmation de l’intoxication nécessite toujours une analyse chromatographique [1]. Nous rapportons le cas d’un homme âgé de 67 ans se présentant aux urgences en déclarant une tentative de suicide par prise excessive d’alprazolam. Des examens complémentaires tardifs démontrèrent une intoxication au méthanol. Méthodes : Un criblage toxicologique classique (recherche de benzodiazépines, d’antidépresseurs, de barbituriques, de neuroleptiques, d’opiacés, de salicylés, de paracétamol et d’éthanol) sur le sang prélevé à l’admission a été réalisé, combinant des méthodes enzymatiques et immunologiques (Architect Ci4100–Abbott®) et une analyse chromatographique (Alliance–Waters®). La recherche spécifique de méthanol a été réalisée ultérieurement par chromatographie gazeuse couplée à un détecteur à ionisation de flamme (GC/FID-2010 – Shimadzu®). Résultats : A l’admission, le patient était très somnolent, se plaignait d’acouphènes, de paresthésies des quatre membres et d’un engourdissement de la joue. La biologie sanguine était normale, à l’exception de bicarbonates quelque peu diminués (21.9 mmol/L) et d’un trou anionique légèrement augmenté (23 mEq/L). Le pH ne fut pas contrôlé. L’examen toxicologique initial révéla un taux suprathérapeutique d’alprazolam (173 µg/L), ainsi que des taux infrathérapeutiques de nordiazépam et de trazodone. L’alcoolémie était négative. Le patient fut placé en hospitalisation provisoire pour surveillance. Vingt-quatre heures après l’admission, ce dernier avoua une consommation de méthanol. Une biologie de contrôle confirma une intoxication significative (méthanolémie à 1,54 g/L – des décès sont observés dès 1g/L), de même que des bicarbonates effondrés à 12 mmol/L, un trou anionique augmenté à 29 mEq/L et un pH artériel à 7,21. Le patient fut transféré en réanimation. Le traitement consista à administrer du bicarbonate, de l’acide folinique (50 mg/6 h), du 4-méthyl-pyrazole (15 mg/kg en 45 min.). L’hémodialyse réalisée, combinée au traitement, permit de réduire rapidement la méthanolémie, comme décrit ci-dessous: Moment du prélèvement Admission Admission +24 h Admission +39 h Admission +46 h Admission +61 h Méthanol Non fait 1,54 g/L 0,54 g/L 0,17 g/L <0,05 g/L Malgré un traitement très tardif, soit plus de 24 heures après l’admission, le patient fut autorisé à quitter l’hôpital après 3 jours, et ce sans aucune séquelle apparente. Conclusion : Le diagnostic d’une intoxication au méthanol est rendu compliqué par l’absence de symptômes spécifiques précoces. La présence d’une acidose métabolique avec trou anionique augmenté doit conduire à une recherche spécifique de méthanol. Le traitement repose sur l’administration d’un inhibiteur de l’alcool déshydrogénase, tel que le 4-méthyl-pyrazole ou l’éthanol, la correction de l’acidose par bicarbonates et l’hémodialyse au besoin. Référence : [1] Jeffrey A. et coll. Approach to the treatment of methanol intoxication. Am J Kidney Dis. 2016;68(1):161-7. [less ▲]

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See detailNew low electron flux facility in the 0 to 3.5 MeV range for the study of induced signal in JUICE instruments: UVS and MAJIS measurements
Carapelle, Alain ULiege; Grodent, Denis ULiege; Langevin, Yves et al

Poster (2017, October)

We designed and built a new test facility to investigate signal induced by electrons in the 0-3.5 MeV in the JUICE UVS and MAJIS instruments. The facility uses radioisotopes sources to produce low flux of ... [more ▼]

We designed and built a new test facility to investigate signal induced by electrons in the 0-3.5 MeV in the JUICE UVS and MAJIS instruments. The facility uses radioisotopes sources to produce low flux of electrons (< 6000 electrons/cm².s). We present the facility, its capabilities and the results of measurements on UVS and MAJIS. [less ▲]

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See detailNonlinear asteroseismology: insight from amplitude and frequency modulations of oscillation modes in compact pulsators from Kepler photometry
Zong, Weikai; Charpinet, Stéphane; Vauclair, Gérard et al

in EPJ Web of Conferences (2017, October), 160

Nonlinear mode interactions are difficult to observe from ground-based telescopes as the typical periods of the modulations induced by those nonlinear phenomena are on timescales of weeks, months, even ... [more ▼]

Nonlinear mode interactions are difficult to observe from ground-based telescopes as the typical periods of the modulations induced by those nonlinear phenomena are on timescales of weeks, months, even years. The launch of space telescopes, e.g., Kepler, has tremendously changed the situation and shredded new light on this research field. We present results from Kepler photometry showing evidence that nonlinear interactions between modes occur in the two compact pulsators KIC 8626021, a DB white dwarf, and KIC 10139564, a short period hot B subdwarf. KIC 8626021 and KIC 10139564 had been monitored by Kepler in short-cadence for nearly two years and more than three years without interruption, respectively. By analyzing these high-quality photometric data, we found that the modes within the triplets induced by rotation clearly reveal different behaviors: their frequencies and amplitudes may exhibit either periodic or irregular modulations, or remain constant. These various behaviors of the amplitude and of the frequency modulations of the oscillation modes observed in these two stars are in good agreement with those predicted within the amplitude equation formalism in the case of the nonlinear resonant mode coupling mechanism. [less ▲]

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See detailFiscalité des A.S.B.L. : TVA/IPM/ISOC - Avis de tempête !
Noirhomme, Philippe; Garroy, Sabine ULiege

Conference (2017, October)

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See detailLifetime of 5 non-commercial boluses evaluated in dairy cows by X Rays and plasmatic trace elements concentrations
Guyot, Hugues ULiege; Cheleux, Gaël ULiege; Wajda-Dubos, Jean-Pierre et al

Poster (2017, October)

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See detailThe role of soil microbial diversity and activity in ecosystem functioning
Carnol, Monique ULiege

Conference (2017, October)

Soil microorganisms and soil organic matter availability regulate soil quality and fertility. Through their activity in biogeochemical cycling processes, soil microorganisms decompose soil organic matter ... [more ▼]

Soil microorganisms and soil organic matter availability regulate soil quality and fertility. Through their activity in biogeochemical cycling processes, soil microorganisms decompose soil organic matter and thus regulate nutrient availability and primary production. Landuse changes, such as a shift from forest to agricultural land, as well as a change in tree species composition, can modify microbial diversity and activity and consequently ecosystem funcitoning. Some parameters can be used as biological indicators, relating land use management to soil functioning and ecosystem services. New molecular tools allow now an in-depth investigation of the role of soil microbial diversity in ecosystem functioning. I will adress biogeochemical cycling processes and their relation to ecosystem functioning, with particular emphasis on forest ecosystems. Examples will be drawn from recent research projects investigating the links between tree species, tree species diversity, and soil microbial biomass, diversity and activity in temperate and tropical forests. [less ▲]

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See detailCessation of nucleos(t)ide analogue treatment after HBeAg seroconversion is associated with a 4-fold increased risk of relapse in cirrhotic compared to non-cirrhotic patients
Van Hees, S; Bourgeois, S; Van Vlierberghe, H et al

in Hepatology (Baltimore, Md.) (2017, October), 66(S1), 934

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See detailIntérêt du suivi thérapeutique pharmacologique des anticoagulants oraux directs (DOACs) dans la pratique hospitalière
DUBOIS, Nathalie ULiege; PETERS, Pierre ULiege; DENOOZ, Raphael ULiege et al

Poster (2017, October)

Objectif : Les anticoagulants oraux directs (DOACs) – apixaban, dabigatran et rivaroxaban - sont de plus en plus utilisés comme alternative aux antagonistes de la vitamine K classiques (acénocoumarol et ... [more ▼]

Objectif : Les anticoagulants oraux directs (DOACs) – apixaban, dabigatran et rivaroxaban - sont de plus en plus utilisés comme alternative aux antagonistes de la vitamine K classiques (acénocoumarol et warfarine). Ils ont pour avantage de ne pas nécessiter une surveillance biologique régulière puisqu’ils ont une dose–réponse prédictible et peu d’interactions médicamenteuses et alimentaires. Cependant, en cas d’hémorragie ou d’acte chirurgical à réaliser en urgence, il est utile de pouvoir les doser de manière spécifique afin d’adapter le traitement du patient (1). Afin de répondre à ce besoin, une méthode de dosage simultané de l’apixaban, du dabigatran et du rivaroxaban dans le sérum par chromatographie en phase liquide à ultra haute pression couplée à un spectromètre de masse en tandem (UHPLC/MSMS) a été mise au point et validée dans notre laboratoire. Méthode : Après l’ajout de 3 standards internes deutérés (apixaban-13C-D3, dabigatran-d3 et rivaroxaban-d4), l’échantillon de sérum (100µl) subit une précipitation par 400 µl d’acide formique à 1% dans du méthanol. 10µl de surnageant sont ensuite injectés en UPLC/MSMS. La séparation chromatographique se fait sur une colonne Acquity HSS T3 (2.1*100mm, 1.8µm, Waters). La phase mobile est délivrée selon un mode gradient, elle se compose d’un tampon formiate d’ammonium 5mM pH3 et d’acide formique à 0.1% dans du méthanol. Les composés sont ensuite analysés par spectrométrie de masse tandem en mode MRM. Deux transitions sont enregistrées par molécule. L’analyse de six standards de calibration en double pendant 3 jours a permis d’établir la fonction de réponse la mieux adaptée et la réalisation de 5 standards de validation en triple pendant 3 jours a permis de calculer les limites de la méthode analytique (justesse, précision, limites de détection et de quantification, linéarité, incertitude de mesure et exactitude). Résultats : Les 3 composés sont séparés en 10 minutes. La méthode est linéaire jusque 385 ng/mL, 302 ng/ml et 297 ng/ml respectivement pour apixaban, dabigatran et rivaroxaban. Les biais et les coefficients de variation (répétabilité et précision intermédiaire) sont inférieurs à 15% dans l’intervalle de dosage. Les limites supérieures et inférieures de l’intervalle de tolérance sont comprises dans les limites d’acceptation de 30% pour les concentrations supérieures à 50ng/ml et de 40% pour les concentrations inférieures à 50 ng/ml. Les LOQ sont respectivement de 27.9 ng/ml, 22.5 ng/ml et 21.6 ng/ml pour apixaban, dabigatran et rivaroxaban. Conclusions : La méthode de dosage des DOACs dans le sérum est validée avec succès et répond parfaitement aux critères imposés par l’European Medicines Agency. La préparation des échantillons est très simple, la séparation chromatographique est rapide, la spécificité de l’analyse est garantie par l’étude de deux transitions par molécule. Référence : 1. N. Gendron, D. Smadja, Les anticoagulants oraux directs : quelle est la place de la biologie dans leur suivi et/ou leur utilisation ?, Ann Biol Clin 2015 ; 73 (supplément 1) : 26-28 [less ▲]

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See detailIntramolecular Continuous-Flow Strategy Towards Methylphenidate (Ritalin) Hydrochloride
Gerardy, Romaric ULiege; Winter, Marc; Vizza, Alessandra et al

Poster (2017, October)

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See detailEvolution of rate and genotypes of resistance to macrolide/lincosamide among invasive Group B Streptococcus (GBS): Development of a multiplex PCR tool for simultaneous detection of ErmB, ErmTr, MefA and LsaC resistance genes.
SACHELI, Rosalie ULiege; DESCY, Julie ULiege; MEEX, Cécile ULiege et al

Poster (2017, October)

Methods: A multiplex-PCR, using a set of specifically designed or already described (Kataja, 1999; Malbruny, 2011) primers was developed and used to detect, in GBS, three genes for erythromyc resistance ... [more ▼]

Methods: A multiplex-PCR, using a set of specifically designed or already described (Kataja, 1999; Malbruny, 2011) primers was developed and used to detect, in GBS, three genes for erythromyc resistance, ermB, ermTR, mefA and one gene for clindamycin-resistance lsaC. AdhP gene amplification was used as control for GBS identification. All(219) GBS isolates from invasive infections in newborns and adults received by the Belgian National Reference Center for GBS in 2015, and control strains were tested for erythromycin/clindamycin susceptibility (disk-diffusion/broth- microdilution) and for detection of resistance genes. Results: PCR products demonstrated the expected respective sizes. The method has been validated successfully according to ISO15189 analytical requirements. Of the 219 isolates, 67(30,67%) w resistant to erythromycin and/or clindamycin: 44/67(65,78%) showed a constitutive-MLS phenotype and 10/67(14,9%) the inducible-MLS phenotype. Among the constitutive-MLS strains, 73% harboured ErmB gene, 13% ErmTR, 7% ErmB+mefA and 7% ermB together with LsaC gene. The inducible-MLS strains harboured mostly ErmTr gene (89%) and the others the ErmB gene. Among the 10/67(14,9%) GBS strains with an M-phenotype (isolated resistance to erythromycin), the MefA gene was exclusively detected. Among the 3(4,48%) strains showing an isolated resistance to clindamycin (L-phenotype), the LsaC gene was detected. Conclusion: The developed multiplex PCR is able to detect simultaneously four genes involved in MLS resistance in GBS. In 2015, 30,6% of the invasive GBS strains isolated in Belgium were resist to macrolides and/or lincosamides. The emergence of the L-phenotype in GBS described since 2010, justifies the relevance to also detect LsaC gene together with ErmB, ErmTr and MefA. [less ▲]

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See detailPrevalence and characteristics of group B streptococcus colonization in HIV-infected pregnant women in Belgium
DAUBY, Nicolas; ADLER, Catherine; Y MIENDJE DEYI, Véronique et al

Poster (2017, October)

Objectives: High incidence of GBS sepsis has been reported in HIV-exposed but uninfected (HEU) infants in both developed and developing countries, particularly late-onset diseases. We aimed determining ... [more ▼]

Objectives: High incidence of GBS sepsis has been reported in HIV-exposed but uninfected (HEU) infants in both developed and developing countries, particularly late-onset diseases. We aimed determining the prevalence, the characteristics and the risk factors of GBS carriage in HIV-infected and HIV uninfected pregnant women (PW). Methods : Between 1/01/2011 and 31/12/2013, HIV-infected (n=132) and uninfected (n=123) PW had recto-vaginal swabs for GBS detection performed at 35-37 weeks of gestation and at deliver Demographic, obstetrical and medical data related to HIV-infection were prospectively collected. Serotyping of GBS strains was performed on a limited number of randomly selected samples (26 from HIV-infected and 13 from uninfected PW). Results : The overall prevalence of GBS carriage was not statistically different between HIV-infected and uninfected PW (31% vs 24,4% respectively). Age, nadir CD4 cell count, CD4 cell count at delivery and detectable viral load at delivery were not associated with GBS carriage rate in HIV-infected PW. A distinct pattern of GBS serotype was found in HIV-infected PW who were predomina colonized by serotype III (12/26) while HIV-uninfected PW were mostly colonized by serotype Ia (8/13) (p<0,05). Conclusions: As previously reported in other countries, HIV-infected PW do not have significantly higher rate of GBS colonization. However, our results suggest that HIV-infected PW are more lik be colonized with serotype III strains, that is the main serotype associated with late-onset neonatal sepsis. Ongoing research aims at characterizing the clonal features of the isolated strains [less ▲]

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See detailExploring possibilities through imagination. What can be conceived and what can be seen
Leclercq, Bruno ULiege

Conference (2017, September 29)

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See detailLe cinéma déboussolé
Pieron, Julien ULiege

Conference (2017, September 29)

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Peer Reviewed
See detailAdénocarcinome du canal anal: identification de deux sous-types distincts
Herfs, Michael ULiege

Conference (2017, September 29)

Detailed reference viewed: 17 (1 ULiège)
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See detailLiège Souffle Vert : étude d’un parcours urbain végétalisé
Brahy, Rachel ULiege

Conference (2017, September 29)

Detailed reference viewed: 12 (2 ULiège)
See detailLes voix des "maladies rares" en Belgique : enquête multi-située sur les dynamiques de (re)connaissance d'une catégorie multiple
Duysens, Fanny ULiege

Conference (2017, September 29)

Les "maladies rares" se définissent par un taux de prévalence inférieur à 1 personne sur 2000 en Europe, ainsi que par un ensemble de situations et de problématiques caractéristiques que rencontrent les ... [more ▼]

Les "maladies rares" se définissent par un taux de prévalence inférieur à 1 personne sur 2000 en Europe, ainsi que par un ensemble de situations et de problématiques caractéristiques que rencontrent les patients et les proches concernés. Mais si la catégorie est aujourd'hui largement répandue à travers le monde, les sens qui lui sont donnés et les usages locaux dont elle fait l'objet n'ont rien d’évident. A partir d'une enquête ethnographique multi-située menée dans le contexte de la Belgique, cette recherche doctorale (2015-2018) étudie les processus de construction et de mobilisation de la catégorie de "maladies rares". Il s'agit de "suivre la catégorie" (Marcus, 1995) sur de multiples sites publics et intimes, individuels et collectifs, locaux et globaux, afin d'observer les représentations, les activités et les rapports entre diverses parties-prenantes : des associations de patients et de proches, des spécialistes scientifiques, médicaux et paramédicaux, et des acteurs de santé publique. Comment certaines formes de mobilisations des parties-prenantes observées sur le terrain belge permettent-elles de maintenir, d'étendre ou de modifier la catégorie de "maladies rares" en vue de (re)connaître celle-ci ? Le texte (working paper) qui a été discuté lors de l'atelier doctoral développait une partie du cadre d'analyse de la recherche. [less ▲]

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See detailParler le langage de l'ennemi: la revue TINA contre le storytelling
Claisse, Frédéric ULiege

Conference (2017, September 29)

Dans le sillage des analyses de C. Salmon (2007), le storytelling est devenu, en France, un terme repoussoir utilisé pour dénoncer des techniques nouvelles de communication politique, de marketing ou de ... [more ▼]

Dans le sillage des analyses de C. Salmon (2007), le storytelling est devenu, en France, un terme repoussoir utilisé pour dénoncer des techniques nouvelles de communication politique, de marketing ou de gestion des organisations, qui adoptent la forme du récit à des fins explicites d’influence ou de manipulation. Cette mobilisation de « l’art de raconter des histoires » dans des contextes extra-littéraires n’a pas manqué de faire réagir certains écrivains, inquiets de cette concurrence illégitime sur leur propre terrain. En donnant un nom à « l’ennemi », l’essai de Salmon a ainsi eu pour effet de rendre disponible un nouveau répertoire critique et d’ouvrir à de nouveaux questionnements quant aux pouvoirs que pourrait opposer la littérature à cette emprise de la logique marchande, véritable « hold-up sur l’imaginaire ». Cette réaffirmation de la littérature passe par la promotion de la singularité de son rapport au récit et au langage contre leur dévoiement et leur instrumentalisation par le néolibéralisme. Le mouvement critique s’opère à deux niveaux au moins. D’une part, face à l’inauthenticité du langage du storytelling, l’écriture poétique, déjà profondément renouvelée dans ses modes d’expression depuis les années 1990 (Espitallier, 2011), a encore multiplié la production d’ « objets littéraires non identifiés ». Ces derniers, que C. Hanna théorise sous le nom de « dispositifs » (2010), sont caractérisés par un niveau élevé d’expérimentation, dans des formes et des formats qui investissent souvent ou détournent le « langage de l’ennemi » (pour reprendre l’expression de J-C. Masséra), afin de le dynamiter de l’intérieur (E. Arlix, Y. Pagès, H. Jallon). D’autre part, face à l’impuissance dans laquelle nous laissent les récits dominants, le pouvoir qu’ont les récits d’affecter les individus et les collectifs peut être utilisé à des fins d’émancipation, dans une logique « contre-fictionnelle » (Citton, 2010 ; Revue Multitudes 2012), qui mobilise le « pouvoir de scénarisation » afin de revendiquer notre imaginaire captif. En huit numéros publiés entre 2008 et 2011, la revue de « Littératures » TINA a été un laboratoire où ont convergé ces deux formes de critique, artiste et sociale, du storytelling (et plus largement du néolibéralisme dont il est indissociable). C’est ce corpus que nous nous proposons d’analyser dans cette communication. Contre le double constat d’une « désertification de l’espace littéraire » (éditorial du numéro 1) et d’une certaine désaffection de l’extrême-gauche pour la littérature (Quintane, 2014), TINA a renoué avec une conception exigeante de la littérature comme « lieu de tous les savoirs » et de la fiction comme territoire à part entière où explorer des enjeux politiques et sociaux. Sous quelles formes cette convergence entre création littéraire et critique des mondes contemporains s’est-elle manifestée ? Quel jeu de prises ou d’arguments peut-on dégager des nombreux dispositifs expérimentés par la revue, entre la première partie, explicitement fictionnelle, de chaque numéro, et la seconde, centrée sur des « dossiers » (« territoires », « capitalismes », « argent », « Gender surprise », etc.) ? Enfin, quels acteurs (écrivains, artistes, philosophes, sociologues) ont participé à cette aventure qui marque aussi, sous une forme atténuée, le retour d’une certaine logique collective défensive, générationnelle ou groupale (également perceptible au sein du collectif Inculte), dans un champ littéraire de plus en plus menacé dans son autonomie. [less ▲]

Detailed reference viewed: 36 (2 ULiège)
See detailAltered antimicrobial peptide expression in HPV-related (pre)neoplastic lesions
Lebeau, Alizée ULiege

Conference (2017, September 28)

Detailed reference viewed: 20 (2 ULiège)
See detailHamlet et la culture populaire
Delville, Michel ULiege

Conference (2017, September 28)

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See detailPhenomenology and metaphysics
Seron, Denis ULiege

Conference (2017, September 28)

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See detailPrevenzione quaternaria, primum non nocere
Jamoulle, Marc ULiege

Conference (2017, September 28)

When presented in Durham during the 1995 WICC workshop, the concept of quaternary prevention, born in 1986, has attracted the consensus of the whole audience. In 2003 it has been discretely published in ... [more ▼]

When presented in Durham during the 1995 WICC workshop, the concept of quaternary prevention, born in 1986, has attracted the consensus of the whole audience. In 2003 it has been discretely published in the Wonca dictionary of general practice. Since this time, medicine has changed. The diffusion of knowledge and the sagacity of some researchers has shown that medicine could become dangerous for health. The concepts of overinformation, overdiagnosis, overtreatment and overscreening are now the bread and butter of numerous medical journals and the themes of numerous books and disputes throughout the world. Quaternary prevention encompasses all those domains and supersedes them by putting the relationships between patient and doctor at the center of the ethical reflection. WICC has been instrumental in the genesis and dissemination of the concept of quaternary prevention. This concept is now known and distributed worldwide under the acronym P4. Family physicians form interlinked P4 groups in various countries. It is the theme of many congresses and was propelled to the forefront of the recent Wonca Europe Congress. This concept could induce profound changes in the role of the family physician in health care. Moreover, the combination of the four definitions of prevention provided an amazing view of the activity of family physicians and could renew basic job description in GP / FM. [less ▲]

Detailed reference viewed: 35 (0 ULiège)
See detailLe Stress Oxydant: arnaque ou biologie d'avenir?
LE GOFF, Caroline ULiege

Conference (2017, September 28)

Detailed reference viewed: 24 (1 ULiège)
See detailVitamine D et Vitamin D Binding protein
VRANKEN, Laura ULiege

Conference (2017, September 28)

Detailed reference viewed: 18 (0 ULiège)
See detailDefining Resonant Bonding: Why Are Phase Change Materials Unique ?
Raty, Jean-Yves ULiege

Conference (2017, September 28)

Many of the most extraordinary properties of phase change materials (PCMs) can be attributed to the specific type of bonding found in the crystal structure and called ‘resonant bonding’. However, if ... [more ▼]

Many of the most extraordinary properties of phase change materials (PCMs) can be attributed to the specific type of bonding found in the crystal structure and called ‘resonant bonding’. However, if experimental studies have shown (using FTIR) the unique character of bonding in several PCMs, the ‘resonant’ nature of bonds remains a rather general concept. In this presentation, we use ab initio (DFT) methods to address the bonding properties of various types of crystalline compounds, among which popular phase change materials, and quantify the electronic properties using several indicators. We show the direct correlation between the high polarizability of the bonds and the localization properties of electrons close to the Fermi level which allow to better define resonant bonding. This allows to place resonantly bonded materials, thus PCMs, at a specific location on a scale that extends from ionic compounds to regular semiconductors and finally metals. Our indicator also illustrates clearly the difference between amorphous and crystalline PCMs. [less ▲]

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See detailDébattre la mesure : l'engagement politique de Steve Reich
Orianne, Jean-François ULiege

Conference (2017, September 28)

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See detailLa critique dans l'université contemporaine. Responsabilité et complexité.
Bachelet, Jean-François ULiege

Conference (2017, September 28)

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See detailL’organisation du culte islamique en Belgique
Husson, Jean-François ULiege

Conference (2017, September 28)

This paper presents the current organisation of the Muslim community in the context of Islam as a recognised religion in Belgim. The Muslim representative body, mosques and imams and specific aspects ... [more ▼]

This paper presents the current organisation of the Muslim community in the context of Islam as a recognised religion in Belgim. The Muslim representative body, mosques and imams and specific aspects (chaplaincies, religious education,...) are also dealt with. [less ▲]

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See detailPhotosharing on flickr: a data source for assessing cultural values in urban landscapes
Ginzarly, Manal ULiege

Conference (2017, September 27)

The urban landscape is a stratification of natural, cultural, and socio-economic processes that shape it spatially and experientially over time. The different cultural values embedded in the tangible and ... [more ▼]

The urban landscape is a stratification of natural, cultural, and socio-economic processes that shape it spatially and experientially over time. The different cultural values embedded in the tangible and intangible attributes of the urban landscape are essential to its unique sense of place, and cultural identity. In the era of globalization, rapid urbanization, and unsustainable urban development, cultural heritage has been recognized as an enabler for sustainable development that adapts, and evolves through time with the changes occurring in the city, and at the same time maintains its identity, integrity, and continuity. In this context, UNESCO recommended the application of the Historic Urban Landscape (HUL) approach to the management of thoughtful change and the conservation of cultural heritage. According to the HUL approach cultural values should be taken as a starting point in urban management and development. It is important that decision makers and experts are aware of the potential and variety of cultural values present within exceptional, ordinary, and even deteriorated urban landscapes. In recent years we have witnessed rapid advances in social networking and photo-sharing communities that are generating big data including geographic information, photos, and commentaries. Our assumption is that the phenomenon of user-generated data from social media offers awareness about the dynamic social interactions within places, and express moments, experiences, practices, and identities contributing to the understanding of cultural values associated with the urban landscape. Accordingly, this paper extracts, analyses, and visualizes photos metadata of Tripoli, Lebanon published on Flickr for the application to the fields of urban management and conservation. [less ▲]

Detailed reference viewed: 28 (4 ULiège)
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See detailLes expériences de mort imminente: le point de vue des neurosciences
Martial, Charlotte ULiege

Conference (2017, September 27)

Detailed reference viewed: 44 (2 ULiège)
See detailParticipation à un séminaire
Corswarem, Emilie ULiege

Conference (2017, September 27)

Detailed reference viewed: 19 (4 ULiège)
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See detailA mathematical model of respiration under protective ventilation and extracorporeal CO2 removal therapy
Habran, Simon ULiege; Desaive, Thomas ULiege; MORIMONT, Philippe ULiege et al

Conference (2017, September 27)

The aim of the present study is to build a mathematical model of the respiratory system connected to an extracorporeal CO2 removal device (ECCO2RD) to optimize the gas exchanges efficiency. The model must ... [more ▼]

The aim of the present study is to build a mathematical model of the respiratory system connected to an extracorporeal CO2 removal device (ECCO2RD) to optimize the gas exchanges efficiency. The model must be simple enough to provide rapid solutions and to estimate specific parameters from available clinical data. But it also must be complex enough to be able to simulate the respiratory system when protective ventilation is used and when this system is assisted by an ECCO2RD. [less ▲]

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See detailReactive collisions of electrons with molecules of astrochemical interest: Application to hydride cations and to neutral oxygen
Pop, N; Mezei, J. Zs.; Moulane, Youssef ULiege et al

Poster (2017, September 27)

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See detailDe la R&D à la mise sur le marché de produits industriels, évolutions de la recherche au service des entreprises
Blecker, Christophe ULiege

Conference (2017, September 26)

Ce séminaire retrace par des exemples concrets de développement de produits l'évolution des interactions entre le secteur alimentaire et la recherche fondamentale et appliquée. L'objectif est de mettre en ... [more ▼]

Ce séminaire retrace par des exemples concrets de développement de produits l'évolution des interactions entre le secteur alimentaire et la recherche fondamentale et appliquée. L'objectif est de mettre en avant l'apport de certaines méthodes de travail pour obtenir un partenariat entreprises-centres de recherche optimal. Pour conclure, il présente les principaux résultats de recherche dont son domaine dont les entreprises pourraient trouver un intérêt. [less ▲]

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See detailThe weapon system behind the point: Early Gravettian hunting technologies at Maisières-Canal
Taipale, Noora ULiege; Coppe, Justin ULiege; Touzé, Olivier ULiege et al

Conference (2017, September 23)

Hunting and preparing for the hunt – manufacturing, using, and repairing the equipment – were undoubtedly important and time-consuming activities in the lives of Palaeolithic groups [1, 2]. Studying ... [more ▼]

Hunting and preparing for the hunt – manufacturing, using, and repairing the equipment – were undoubtedly important and time-consuming activities in the lives of Palaeolithic groups [1, 2]. Studying hunting equipment in detail is thus essential for our understanding of a crucial aspect of Palaeolithic human behaviour and allows us to understand developments in human technologies and problem-solving across wide geographical and chronological ranges. Yet, our current knowledge about the development of prehistoric hunting technologies (projecting modes, weapon design) is mainly based on a few important but isolated discoveries of organic remains in Europe, such as the Lower Palaeolithic spears or spear fragments recovered at Schöningen, Lehringen, and Clacton-on-Sea, the Solutrean and Magdalenian spear-thrower hooks, and the arrows and bow fragments from Mesolithic and Neolithic contexts [3]. In this paper we demonstrate how to exploit the full potential of a much more durable and ubiquitous type of remains, lithic armatures, in the study of Palaeolithic hunting practices. We present the results of a collaborative project that combines technological and functional analysis with experimental archaeology, and aims at understanding the manufacture and use of a specific lithic projectile type, the Early Gravettian tanged point. Our archaeological material comes from the Gravettian occupation phase of the open-air site of Maisières-Canal (Belgium), dated between 33 and 32 cal BP [4]. This stratigraphically well-isolated sequence has yielded an important collection of tanged points that are in excellent state of preservation. A combined study of the finished armatures and the related shaping waste allows us to present a new, more comprehensive view of the characteristics and constraints of the shaping method. The points were made on large, thin blades produced by hard or soft stone percussion, and subsequently shaped by several generations of direct, flat, invasive (sometimes overshot) removals with an organic hammer. These points, which all display a long, elaborately shaped tang, thus form a distinct tool type with a unique chaîne opératoire and a very particular morphology in terms of weapon design and hafting systems. Many of the points show clear macroscopic and microscopic damage from impact that can be attributed to their use as armatures. The morphology, the organisation, and the orientation of the traces allowed us to propose specific hafting modes that were tested experimentally. The experimental program focused on both the details of the hafting mode and the mode of projection. In addition, alternative tool uses such as butchering were considered, and the points were framed within the broader functional context of tanged and non-tanged tools recovered at the site. The results allow evaluating what kind of weapon system the tanged points were part of, and what their place was in the Early Gravettian technology. We argue that when approached from an experimental and techno-functional point of view, lithic projectile points can help us understand the development of hunting technologies as well as broader patterns of technological change. References:[1] Ellis, C.J., 1997. Factors influencing the use of stone projectile tips. In: Knecht, H. (Ed.), Projectile Technology. Springer Science & Business Media, pp. 37–74 [2] Greaves, R ., 1997. Hunting and multifunctional use of bows and arrows. In: Knecht, H. (Ed.), Projectile Technology. Springer Science & Business Media, New York, pp. 287–320 [3] Knecht, H., 1997. Projectile technology. Springer Science & Business Media, New York [4] Jacobi, R. M., Haesaerts, P., Jadin, I., Basell, L.S., 2010. Radiocarbon chronology for the Early Gravettian of northern Europe: new AMS determinations for Maisières-Canal, Belgium. Antiquity 84 (323), 26–40 [less ▲]

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See detailLes enjeux didactiques de la mobilité étudiante en Francophonie : état des lieux et perspectives
Meunier, Deborah ULiege

Conference (2017, September 23)

En quoi les programmes de mobilité étudiante universitaire obligent-t-ils à repenser la didactique des langues et des cultures, ses objectifs, ses ambitions, ses conditions d’existence, ses modes ... [more ▼]

En quoi les programmes de mobilité étudiante universitaire obligent-t-ils à repenser la didactique des langues et des cultures, ses objectifs, ses ambitions, ses conditions d’existence, ses modes d’expression locaux ? Quelles sont les spécificités de l’enseignement-apprentissage du français à/par ces étudiants en séjour dans des universités francophones ? Après une brève mise en contexte sociohistorique de la mobilité étudiante, en particulier en Francophonie, nous proposerons, d’une part, un état des lieux des recherches sur l’enseignement du français pour ce public d’étudiants universitaires nomades et plurilingues, et, d’autre part, quelques résultats de nos recherches passées et en cours. L’objectif de cette communication sera de présenter des pistes susceptibles de pallier le vide pédagogique et les difficultés rencontrées par les enseignants et les étudiants mobiles. Ce public d’apprenants, à la fois « exigeant et fuyant » (Anquetil, 2011), nécessite des ajustements, des dispositifs, des méthodes à la fois pluriels et spécifiques, dont nous tracerons les lignes principales. Notre intervention bénéficiera d’un triple éclairage : celui de la littérature scientifique récente (notamment les travaux de chercheurs publiés dans un numéro du Langage et l’Homme, à paraitre en juin 2017, que nous coordonnons) ; de notre recherche doctorale sur les représentations des acteurs (institutions et étudiants) à propos de la mobilité étudiante en Europe et des langues, en particulier du français (2013) ; et enfin, d’une recherche actuelle que nous menons sur les compétences écrites en français d’étudiants universitaire non francophones, débutée en 2016 à l’université de Sherbrooke, au Québec. [less ▲]

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See detailLa lettera e l’atmosfera. L’opera di Simenon al cinema
Tomasovic, Dick ULiege

Conference (2017, September 23)

Si l’œuvre de Simenon apparaît comme une évidente vache à lait de l’adaptation cinématographique (récits populaires, formes simples, personnages caractérisés, intrigues criminelles bien ficelées, force ... [more ▼]

Si l’œuvre de Simenon apparaît comme une évidente vache à lait de l’adaptation cinématographique (récits populaires, formes simples, personnages caractérisés, intrigues criminelles bien ficelées, force dramaturgique évidente), elle a aussi exercé une forte séduction sur un nombre important de cinéastes pour ses qualités descriptives, ses peintures sociales, et, surtout, pour une tonalité atmosphérique qui lui serait propre. Partant d’un rapide panorama des adaptations filmiques des œuvres de Simenon, cette intervention s’efforcera, à travers le commentaire de quelques œuvres déterminantes, de cerner la question de la mise en scène cinématographique de la fameuse atmosphère simenonienne. [less ▲]

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See detailSemantic externalism(s) and cognitive transparency
Leclercq, Bruno ULiege; De Brabanter, Philippe

Conference (2017, September 22)

Detailed reference viewed: 26 (1 ULiège)
Peer Reviewed
See detailPsychological Predictors and Consequences of Hearing Health Behaviors in Older Adults
Marquet, Manon ULiege; Chasteen, Alison L; Plaks, Jason E et al

Poster (2017, September 22)

Introduction: Hearing loss is a common chronic condition affecting older adults in Western populations [1, 2]. Even if older adults could benefit from hearing aid use, they are reluctant to wear them [1 ... [more ▼]

Introduction: Hearing loss is a common chronic condition affecting older adults in Western populations [1, 2]. Even if older adults could benefit from hearing aid use, they are reluctant to wear them [1]. The purpose of the present study was twofold: a) to examine whether older adults’ implicit theories regarding the modifiability of abilities in general would predict their hearing health behaviors; and (b) to assess consequences of these behaviors on subjective aging. Methods: One hundred and sixty-three older adults (Mean age = 68.62, SD = 5.40) completed, among other questionnaires, questions assessing their implicit theories of ability (i.e., seeing general abilities as fixed vs. improvable with effort [3]) and their subjective age (i.e., felt age, do age, look age, and interest age [4]). They also reported their perceptions of the benefits of various hearing health behaviors for slowing the effects of aging (i.e., getting their hearing tested and using hearing aids) as well as their intentions to engage in those behaviors. Results: We found that the more older people considered that abilities are alterable, the more they perceived hearing health behaviors as being beneficial, which in turn increased their intentions to engage in these behaviors. Also, the greater their intentions, the younger subjective age they reported. Key conclusions: These relationships between implicit theories, hearing health behaviors, and subjective age are particularly important to take into account. Indeed, neglecting hearing problems and experiencing an older subjective age may have detrimental health-related outcomes over time [5, 6]. 1. Feder, K., Michaud, D., Ramage-Morin, P., McNamee, J., & Beauregard, Y. (2015). Prevalence of hearing loss among Canadians aged 20 to 79: Audiometric results from the 2012/2013 Canadian Health Measures Survey. Health Reports, 26(7), 18-25. 2. Lin, F. R., Thorpe, R., Gordon-Salant, S., & Ferrucci, L. (2011). Hearing loss prevalence and risk factors among older adults in the United States. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 66(5), 582-590. doi: doi:10.1093/gerona/glr002 3. Dweck, C. S. (1999). Self-theories: Their role in motivation, personality, and development. Philadephia, PA: Psychology Press. 4. Kastenbaum, R., Derbin, V., Sabatini, P., & Artt, S. (1972). “The ages of me”: Toward personal and interpersonal definitions of functional aging. The International Journal of Aging and Human Development, 3(2), 197-211. 5. Bainbridge, K. E., & Wallhagen, M. I. (2014). Hearing loss in an aging American population: Extent, impact, and management. Annual Review of Public Health, 35, 139-152. doi: 10.1146/annurev-publhealth-032013-182510 6. Kotter-Grühn, D., Kornadt, A. E., & Stephan, Y. (2015). Looking beyond chronological age: Current knowledge and future directions in the study of subjective age. Gerontology, 62(1), 86-93. doi: 10.1159/000438671 [less ▲]

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See detailNose and Sleep-disordered Breathing
POIRRIER, Anne-Lise ULiege

Conference (2017, September 22)

The nose is the input channel for the airflow. Its rigid and erectile structures determine the outline and the output of the airflow in the upper airway. Nose obstruction, due to reversible or non ... [more ▼]

The nose is the input channel for the airflow. Its rigid and erectile structures determine the outline and the output of the airflow in the upper airway. Nose obstruction, due to reversible or non reversible factors, produces collapsing forces that are manifest downstream in the collapsible pharynx. Moreover, nose pathologies result in unstable oral breathing, decreased activation of nasal-ventilatory reflex and reduced lung nitric oxide. Long-term oral breathing impacts on the craniofacial growth. The management of nose pathologies coud be medical, mechanical (nose dilators) or surgical. Nasal management should be integrated in a multimodal approach, considering the involvement of a multi-level obstruction, and truly reflecting the complexity of sleep disordered breathing. [less ▲]

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See detailUn MOOC sur l’enseignement du FLE : la question de la médiation des savoirs et de l’évaluation des savoir-faire
Meunier, Deborah ULiege; Thonard, Audrey ULiege

Conference (2017, September 22)

« Ma classe de FLE » est un projet de MOOC destiné à de (futurs) enseignants de français langue étrangère. Constitué de 8 modules interactifs, ce MOOC vise à développer les connaissances et compétences ... [more ▼]

« Ma classe de FLE » est un projet de MOOC destiné à de (futurs) enseignants de français langue étrangère. Constitué de 8 modules interactifs, ce MOOC vise à développer les connaissances et compétences des participants en matière de gestion des interactions (orales et écrites) et des ressources (notamment numériques), mais aussi de développement des compétences grammaticales et interculturelles des apprenants. A partir d’exemples concrets d’activités, nous interrogerons d’un point de vue didactique deux aspects liés à ce dispositif d’enseignement/apprentissage innovant : la médiation des savoirs et les pratiques d’évaluation. En effet, les enjeux d’une pédagogie renversée, où l’apprenant est au centre de l’apprentissage et le numérique à son service, impliquent une (re)configuration des rôles des acteurs du dispositif (apprenants, enseignants, tuteurs, animateurs) dans la médiation des savoirs d’une part, et l’évaluation des acquis d’apprentissage d’autre part. Nous verrons comment nous avons mis en œuvre la co-construction collaborative et ouverte de savoirs, et quels dispositifs d’évaluation (par les pairs, par essai-erreur) nous avons proposés, en accord avec la pédagogie (inter)active dans laquelle s’inscrit notre projet de MOOC. [less ▲]

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See detailLes interactions enseignant/enfants comme soutien au développement langagier des enfants en classe maternelle
Leroy, Sandrine ULiege; Bergeron-Morin, Lisandre ULiege; Desmottes, Lise ULiege et al

in Les entretiens de Bichat : les entretiens d'orthophonie 2017 : Les pathologies du langage chez l'enfant de moins de 6 ans: facteurs de risque (FR), facteurs de protection (FP) (2017, September 22)

L'école maternelle constitue un contexte privilégié pour soutenir le développement du langage et de la communication des enfants. La qualité des interactions entre l’enseignant et les enfants de sa classe ... [more ▼]

L'école maternelle constitue un contexte privilégié pour soutenir le développement du langage et de la communication des enfants. La qualité des interactions entre l’enseignant et les enfants de sa classe est reconnue comme étant l’aspect le plus déterminant de la qualité éducative, notamment en ce qui concerne le développement langagier. Cet article a pour objectif de faire un survol de la littérature sur le développement du langage des enfants en contexte préscolaire, sur le rôle que peut y jouer l’enseignant, ce qui ouvre des perspectives quant aux modalités de développement professionnel des enseignants en maternelle. [less ▲]

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See detailConférence d'ouverture : La morale de 1964 : une écriture en débats
Cormann, Grégory ULiege; Bourgault, Jean

Conference (2017, September 22)

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See detailTowards a covering aerospray method for quantitative analyses of pharmaceutical tablets using surface-enhanced Raman chemical imaging (SER-CI)
Cailletaud, Johan ULiege; De Bleye, Charlotte ULiege; Dumont, Elodie ULiege et al

Conference (2017, September 22)

In recent years, the use of SERS-CI in pharmaceutical sciences has increased in order to study the distribution of low-dose compounds in solid dosage forms [1]. This technique allows to improve the ... [more ▼]

In recent years, the use of SERS-CI in pharmaceutical sciences has increased in order to study the distribution of low-dose compounds in solid dosage forms [1]. This technique allows to improve the sensitivity of conventional Raman microscopy and to reduce significantly the image acquisition time by exalting the signal information. However, the applications of SERS-CI in the pharmaceutical field remain limited, especially due to the difficulty of obtaining a homogeneous deposit of metallic nanoparticles on the sample surface. Generally, the covering method used on the tablet is a drop casting deposition due to its simplicity and rapidity of implementation. Despite the colloidal solution deposit is not fully controlled. The inhomogeneous covering is the result of the “coffee-ring” effect that concentrates the nanoparticles at the edges of the droplet [2]. This implies remarkable variations of the SERS analyte signal’s intensity at different places. For a more reproducible and homogeneous coating, an aerospray method using a homemade apparatus was developed (Figure 1). The device is composed with a pair of coaxial tubes, the colloidal solution is pulled through the inner tube from a syringe pump and the outer tube is connected to a source of high pressure gas. Nitrogen, used as a nebulizing gas, creates a flow of small droplets of nanoparticles that are nearly dry when they hit the sample surface. The aerospray device is easy to implement and the entire surface of the tablet is covered by the SERS substrate in a homogeneous way. By using this covering method, the potential of SERS-CI is improved and making it a suitable technique for quantitative analyses of low drug concentrations or impurities in pharmaceutical tablets. [less ▲]

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See detailMyoferlin controls mitochondrial structure in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness
Rademaker, Gilles ULiege; Hennequière, Vincent ULiege; Brohée, Laura ULiege et al

Poster (2017, September 22)

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, and the third leading cause of cancer related death. Therapeutic options remain very limited and are still based on ... [more ▼]

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, and the third leading cause of cancer related death. Therapeutic options remain very limited and are still based on classical chemotherapies. Cell fraction can survive to the chemotherapy and is responsible for tumor relapse. It appears that these cells rely on OXPHOS for survival. Myoferlin, a membrane protein involved in cell fusion was recently shown by our laboratory to be overexpressed in pancreatic cancer. In the present study, we discovered that myoferlin was more expressed in cell lines undergoing oxidative phosphorylation (OXPHOS) than in glycolytic cell lines. In the former cell lines, we showed that myoferlin silencing reduced OXPHOS activity and forced cells to switch to glycolysis. The decrease in OXPHOS activity is associated with mitochondrial network disorganization. Dynamin-related protein (DRP)-1 phosphorylation led us to suggest mitochondrial fission, reducing cell proliferation, ATP production and inducing autophagy and ROS accumulation. To confirm the clinical importance of myoferlin in PDAC, we showed that low myoferlin expression was significantly correlated to high overall survival. Myoferlin staining of PDAC sections was negatively correlated with several 18FDG PET indices indicating that glycolytic lesions had less myoferlin. As the mitochondrial function is demonstrated to enhance the cell resistance to the treatment, the metabolic switch forced by myoferlin silencing could open up a new perspective in the development of therapeutic strategies. [less ▲]

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See detailPerformance-based fire design and the U.S. prescriptive guidelines: A comparative study
Elhami Khorasani, Negar; Fang, Chenyang; Gernay, Thomas ULiege

in Proceedings of the 39th IABSE Symposium (2017, September 21)

Current codes and standards for fire design of structures in the United States are mainly based on design at the component level using prescriptive approaches, while performance-based design for fire can ... [more ▼]

Current codes and standards for fire design of structures in the United States are mainly based on design at the component level using prescriptive approaches, while performance-based design for fire can be used to address the needs for designing modern buildings with cost-effective solutions. Previous research shows that, when system-level performance is considered, fire protection on secondary beam elements in composite steel-concrete floor systems is not necessary due to the development of a membrane action in the concrete slab during fire. This study compares the fire design of a 9-story office building using prescriptive and performance-based designs. The safety levels of the two designs are investigated and compared. It is shown that performance-based design can be used to achieve the required level of safety currently enforced in the U.S. prescriptive guidelines, while providing an opportunity for cost reduction in fire protection material. [less ▲]

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See detail“Flippons nos classes de FLE !" : Le modèle de classe inversée adopté à l’université de Liège pour l’enseignement/apprentissage du FLE
Thonard, Audrey ULiege

Conference (2017, September 21)

Dix ans après la création d’un premier dispositif d’apprentissage en ligne, l’Institut Supérieur des Langues Vivantes a souhaité revoir son intégration du numérique dans les cours de FLE destiné aux ... [more ▼]

Dix ans après la création d’un premier dispositif d’apprentissage en ligne, l’Institut Supérieur des Langues Vivantes a souhaité revoir son intégration du numérique dans les cours de FLE destiné aux étudiants Erasmus « in ». Dans cette communication, nous présenterons les contraintes et les opportunités qui ont modifié, lentement mais sûrement, notre conception de l’enseignement en ligne et celle de la classe inversée. [less ▲]

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See detailAgeism and dementia stigma among healthcare professionals
Schroyen, Sarah ULiege; Adam, Stéphane ULiege; Missotten, Pierre ULiege

Poster (2017, September 21)

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See detailEffect of solution treatment on the fracture mechanisms of AlSi10Mg parts produced by Selective Laser Melting
Delahaye, Jocelyn ULiege; Mertens, Anne ULiege; Dedry, Olivier ULiege et al

Poster (2017, September 21)

Al alloy AlSi10Mg processed by Selective Laser Melting (SLM) displays high hardness and tensile strength due to its very fine eutectic microstructure [1]. However, as-built material exhibits low ductility ... [more ▼]

Al alloy AlSi10Mg processed by Selective Laser Melting (SLM) displays high hardness and tensile strength due to its very fine eutectic microstructure [1]. However, as-built material exhibits low ductility which is detrimental for applications where a high resilience is needed. To overcome this issue, solution heat treatment can be applied to soften and ductilize the material [2]. The very fine eutectic microstructure then turns into a dispersion of coarse globular Si precipitates. The distribution of Si precipitates seems to play a role in the fracture mechanism in as-built as well as solutionized tempers, but this effect is not yet fully understood [1,3]. Moreover, the lack of quantitative data makes it difficult to link precisely the fracture mechanisms to specific microstructural features. This study aims at investigating the role of the Si phase in the rupture mechanism, for both as-built and solutionized samples. It will focus more particularly on the heterogeneity of the distribution of Si precipitates where cracks are more likely to occur. Al cells size, along with the volume fraction and distribution of Si precipitates have been quantified by SEM image analysis. Al lattice parameter and Si crystallite size have been determined by X-ray diffraction/Rietveld analysis. For the image analysis, two types of specific zones have been observed i.e. the core and boundary of melt pools and Al grains, at different locations for representativity. These quantitative data have been compared with typical features observed on the fractured surface of tensile specimen. 1. D.-K. Kim et al. J. Alloys Compd. 686 (2016) 281. 2. W. Li et al., Mat. Sci. & Eng. A. 663 (2016) 116, 3. N.T. Aboulkhair et al. Mat. Sci. & Eng. A. 667 (2016) 139. [less ▲]

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See detailTowards the development of a dual mode fluorescence/SERS dopamine aptasensor
Dumont, Elodie ULiege; De Bleye, Charlotte ULiege; Cailletaud, Johan ULiege et al

Poster (2017, September 21)

This work was dedicated to the development of a dual mode fluorescence and surface-enhanced Raman scattering (SERS) dopamine aptasensor. The preparation of the aptasensor was first optimised. Thereafter ... [more ▼]

This work was dedicated to the development of a dual mode fluorescence and surface-enhanced Raman scattering (SERS) dopamine aptasensor. The preparation of the aptasensor was first optimised. Thereafter, calibration curves were realised by means of fluorescence quenching and SERS. Finally, the specificity of both methods was tested. [less ▲]

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See detailNon-classical structures and association of the OXPHOS complexes in Euglena gracilis and Polytomella sp.
Miranda Astudillo, Héctor Vicente ULiege; Yadav, Sathish; Colina-Tenorio, Lilia et al

Conference (2017, September 21)

To date, the idea that the OXPHOS complexes can associate with each other in larger structures named supercomplexes [1] is generally accepted. This association can allow a more efficient transport of ... [more ▼]

To date, the idea that the OXPHOS complexes can associate with each other in larger structures named supercomplexes [1] is generally accepted. This association can allow a more efficient transport of electrons to minimize the generation of reactive oxygen species during electron transfer reactions and can also be involved in the regulation of the mitochondrial metabolism in response to different stimuli, carbon sources or stress conditions. Recently, the arising studies outside the classical models yeast and bovine mitochondria brought to light many unusual characteristics in the ATP synthase from a wide variety of organisms. Due to this, the dimer nature of the mitochondrial ATP synthase is no longer a matter of debate. Given the large structural differences among the peripheral stator and dimerization modules of mitochondrial ATP synthases described so far, it is of relevance to study a wider number of species to gain insight into the structural diversity of their OXPHOS complexes. Recently, our group showed that at least 41 of the non-canonical subunits reported in trypanosomes are also present in Euglena complexes along with 48 classical subunits described in other eukaryotes including green plants [2]. Further purification of the complexes I, III, IV and V by liquid chromatography after solubilization with n-β-dodecyl-maltoside and the subsequent analysis by single-particle analysis from transmission electron microscopy revealed some unusual features in Euglena respiratory complexes. In the case of complex V the structures of both the catalytic and central rotor parts are conserved while other structural features are original, including a large membrane-spanning region joining the monomers, an external peripheral stalk and a structure that goes through the membrane and reaches the inter membrane space below the c-ring [3]. Complex I also shows an unusually long matricial arm. Complex IV shows an atypical shape compared to that of the bovine one. An unusual association between complexes I and V can be observed when the membranes are extracted with the mild detergent digitonin. Other case of atypical subunit composition is the complex V of chlorophycean algae. Each monomer of the enzyme has 17 polypeptides, eight of which are the conserved, main functional components, and nine polypeptides (Asa1 to Asa9) unique to this lineage that form the robust peripheral stalk in this complex [4]. This complex presents highly stable dimeric and tetrameric structures, and the respiratory complexes have an unusual capacity to reassociate in vitro and restore the functional respirasome. [less ▲]

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See detailAtypical composition and structure of the mitochondrial dimeric ATP synthase from Euglena gracilis
Miranda Astudillo, Héctor Vicente ULiege; Yadav, Sathish; Colina-Tenorio, Lilia et al

Poster (2017, September 21)

Mitochondrial respiratory-chain complexes fromEuglenozoa comprise classical subunits described in other eukaryotes (i.e. mammals and fungi) and subunits that are restricted to Euglenozoa (e.g. Euglena ... [more ▼]

Mitochondrial respiratory-chain complexes fromEuglenozoa comprise classical subunits described in other eukaryotes (i.e. mammals and fungi) and subunits that are restricted to Euglenozoa (e.g. Euglena gracilis and Trypanosoma brucei). Herewe studied the mitochondrial F1FO-ATP synthase (or Complex V) fromthe photosynthetic eukaryote E. gracilis in detail. The enzymewas purified by a two-step chromatographic procedure and its subunit compositionwas resolved by a three-dimensional gel electrophoresis (BN/SDS/SDS).Twenty-two different subunits were identified by mass-spectrometry analyses amongwhich the canonical α, β, γ, δ, ε, and OSCP subunits, and at least seven subunits previously found in Trypanosoma. The ADP/ATP carrierwas also associated to the ATP synthase into a dimericATP synthasome. Single-particle analysis by transmission electron microscopy of the dimeric ATP synthase indicated that the structures of both the catalytic and central rotor parts are conserved while other structural features are original. These new features include a large membrane-spanning re- gion joining the monomers, an external peripheral stalk and a structure that goes through the membrane and reaches the inter membrane space below the c-ring, the latter having not been reported for any mitochondrial F-ATPase. [less ▲]

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See detailQuelques pistes pour relancer la foresterie sociale et la participation en Afrique centrale
Vermeulen, Cédric ULiege

Conference (2017, September 21)

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See detailContinuing education with MOOCs. The case of children’s literature in French-speaking world
Dozo, Björn-Olav ULiege; Van de Poël, Jean-François ULiege; Centi, Valérie et al

Conference (2017, September 21)

1. Introduction Continuing education poses a challenge to the university: the objective is to allow professionals on the job market to enhance their competences through curricula adapted to their needs ... [more ▼]

1. Introduction Continuing education poses a challenge to the university: the objective is to allow professionals on the job market to enhance their competences through curricula adapted to their needs, both in terms of schedule and contents as well as teaching approaches applied. In its MOOCs policy, the University of Liège has identified this priority axis precisely to meet this requirement of schedule, contents and teaching approach. Already taught at the ULg, children's literature offered a perfect option for its pilot project. Popular culture studies are already one of the specificities of the Arts faculty program, and the University thought important to allow for a wider access to this teaching, responding to a growing interest from the civil society. 2. Problem description / challenges Up to now, there were, in French-speaking Belgium, only very few training opportunities on children's literature, based on cutting-edge scientific research, aimed at future or already established teachers. Although children's literature is one of the subject areas taught in secondary schools in French-speaking Belgium, it is not compulsory in the curriculum of aspiring French teachers at higher education institutions (whether universities or hautes écoles). Teaching children's literature thus depends on the teacher's good will: hence the importance of finding a way to train teachers in a subject area they have to teach to secondary school students by putting forward a large-scale but cost controlled solution, open to anyone looking for this specific training, and offering a certificate with a professional value. It was also important for the university to propose an innovative teaching format distinct from the practices generally in force and especially adapted to the adult-learning in terms of pedagogical approach (Thorpe,Edwards,Hanson, 1993). 3. MOOC Format Choosing the MOOC format was an important challenge: on the production level, above all, given the relative inexperience of the teaching staff, supported by a team of instructional designers and a production staff with experience in the creation of online contents for the University's online education platform; but also on the reception level, given that the expected audience is not particularly in line with digital technologies: MOOCs on literature are not the most common ones, and bookish readers are not known to be new technology buffs. The MOOC offers a selection of topics related to the field of children's literature, each under the responsibility of one team member, generally supported by experts. The MOOC tackles two main genres, the novel and the album, presents the publishing market, elaborates on digital literature and explores fictions beyond the book; it includes videos, quizzes, integrative activities, and feedback through forums. Each chapter of our MOOC adopts a modular and autonomous approach. These two characteristics allow learners to follow the MOOC according to their own needs or simply their interests. 4. Initial success The first session, in early March 2017, was a success, with more than 10000 subscribers, quite above the average for MOOCs in French. This is, for many subscribers, their first MOOC experience. Moreover, the motivation and investment of the community is remarkable: the forums are very active, the learners an-swer to and help each other. The feedback is extremely positive, showing a general willingness to partici-pate in the construction of collective knowledge useful for everyone. The information collected from participants is also an early success indicator in terms of population target. 5. Shaping Up for the Future Given this initial success, and in order to enhance this in-depth continued training, the teaching staff is envisioning for next year to develop a summer school linked to the MOOC and implement a blended learning element to our MOOC. The participants would first have to follow the MOOC and complete the required activities, in order to be granted certification. Afterwards, a limited number of these participants (probably around fifty) will be selected based on applications to participate in person to a course that would expand on the introduction to the subject offered by the MOOC. This training would highly benefit from the exceptional resources that the city of Liège holds for children's literature: the Michel Defourny archive, holding more than 30000 pieces, is indeed a unique site in Europe which deserves a better valorization from the University. [less ▲]

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See detailHealing effect of controlled anti-electromigration on conventional and high-Tc superconducting nanowires
Baumans, Xavier ULiege; Lombardo, Joseph ULiege; Brisbois, Jérémy ULiege et al

Conference (2017, September 21)

At the present time, electron beam lithography (EBL) is considered as the reference technique for nanoscale patterning. However, making nanostructures below the sub-10 nm scale is still challenging due to ... [more ▼]

At the present time, electron beam lithography (EBL) is considered as the reference technique for nanoscale patterning. However, making nanostructures below the sub-10 nm scale is still challenging due to broadening effects (forward electron scattering, backscattering, electrostatic charging…), and requires strong investment in terms of cost for state-of-the-art EBL systems. In this sense, alternative methods are continuously explored in order to make such nanofabrication easily reachable. A promising approach consists of inducing atomic diffusion by a large current density. This phenomenon, called electromigration (EM), and well known since the 60’s as a failure mechanism in metallic interconnections [1], still attracts interests from scientists and engineers for its great potential for fabrication of microstructures and for its reversibility character [2, 3]. In this work, we show that the combination of electromigration and anti-electromigration allows the precise tuning of superconducting properties of Al nanoconstrictions and we also observe the reversibility of electromigration failure for this material (see Fig. 1). The same process has been applied on Nb, leading to a more irreversible process, and La2 xCexCuO4. For the latter material, we show that selective migration of oxygen atoms and the consequent doping modification induces a transition from a superconducting state to an insulating state in a reversible way [4]. We also discussed the possibility to enhance the electromigration technique by replacing the complex feedback control by a technique of electropulsing. These researches have direct practical impact as a method to explore the dependence of the characteristic parameters on the exact oxygen content and pave the way for a reversible control of local properties of nanowires. [less ▲]

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See detailFacultative paedomorphosis in pond-breeding newts
Denoël, Mathieu ULiege

Conference (2017, September 21)

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See detailThe Landscape And Evolution Of Somatic Mutations In Bovine Leukemia Virus Induced Tumors
Durkin, Keith ULiege; Artesi, Maria ULiege; Hahaut, Vincent ULiege et al

Conference (2017, September 21)

Bovine Leukemia Virus (BLV) is a deltaretrovirus that integrates into B-cells producing a lifelong infection in cattle. Like its close relative Human T-cell leukemia virus-1 (HTLV-1), BLV induces an ... [more ▼]

Bovine Leukemia Virus (BLV) is a deltaretrovirus that integrates into B-cells producing a lifelong infection in cattle. Like its close relative Human T-cell leukemia virus-1 (HTLV-1), BLV induces an aggressive leukemia/lymphoma in about ~5% of infected individuals. While not a natural host it is possible to infect sheep with BLV and in contrast to cattle, all infected sheep develop tumors at an accelerated rate (~18 months). Historically research into both viruses has primarily focused on their transcripts/proteins. However secondary somatic events are likely to be important as only a subset of infected individuals, following many decades of infection, develop a tumor. At the current time little is known about the landscape of somatic changes in BLV induced tumors and the timing of their occurrence. To address this we have carried out whole genome sequencing of BLV induced tumors from two cattle, and from five sheep with matched normal tissue. This revealed frequent aneuploidy, with orthologous regions of the genome involved in both species and elevated mitochondria DNA copy numbers in tumors. Recurrent structural variants (SVs) were seen affecting the tumor suppressors CDKN2A and ARID1A, both on OAR2. On average ~1400 somatic SNVs were observed in each ovine tumor, with high/moderate impact variants in known cancer drivers genes such as KMT2A, ATRX, RPL22 and KRAS. The five sheep were also sampled at regular time points, prior to leukemia onset, allowing us to examine tumor clone evolution. High throughput sequencing of proviral integration sites showed that the tumor clone represents only a small fraction of the infected cells for the majority of the disease, only expanding rapidly in the terminal stages. Low coverage sequencing of samples prior to tumor development indicates that aneuploidy of OAR9 is a feature of the majority of BLV infected clones. Preliminary nested PCR also showed that many SVs were present prior to tumor development. High throughput approaches are being developed to track both SVs and SNV in the preleukemic stages of the disease. [less ▲]

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See detailWP1 - A summary
Sanchez, Christelle ULiege

Conference (2017, September 20)

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See detailInfluence of the inhomogeneous properties of a superconducting film on the penetration of the magnetic flux
Burger, Loïc ULiege; Avila Osses, Jonathan ULiege; Nguyen, Ngoc Duy ULiege et al

Poster (2017, September 20)

We consider the penetration of magnetic flux perpendicular to a Nb superconducting film containing edge indentations and/or defects. The presence of such defects and indented edges forces the induced ... [more ▼]

We consider the penetration of magnetic flux perpendicular to a Nb superconducting film containing edge indentations and/or defects. The presence of such defects and indented edges forces the induced currents to change direction abruptly, which gives rise to discontinuity lines (d-lines). It has been recently shown, by magneto-optical means, that the shape of the d-lines contain information about the size and the shape of the indentations [1]. Moreover, in contrast with what is commonly assumed, thermomagnetic instabilities are not preferentially triggered near the manufactured indentations, but rather along smooth edges [1]. Such phenomena can lead to unexpected quenching of superconducting samples and considerably damage them, which must be avoided in applications. In this poster, we investigate whether inhomogeneous superconducting properties can be responsible for triggering magnetic flux avalanches. To this aim, we numerically model the flux penetration and determine the distribution of current lines and electric fields for a situation where the superconducting properties vary locally over a small region of the film. We consider the variation of the thickness of the film, the critical current density and the size of the discontinuity. The resulting shapes of the d-lines are deduced and compared to analytical critical state approximations. We also determine the location and the amplitude of the maximal electric field in the film and compare it to typical values which must be reached in order to trigger magnetic flux avalanches. We conclude that the investigated variations lead to levels of electric field which are of the same order of magnitude as those generated by artificial indentations. [less ▲]

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See detailBlending of Radial HF Radar Surface Current and Model Using ETKF Scheme For The Sunda Strait
Subekti Mujiasih, ULiege; Riyadi, Mochammad; Wandono, Dr et al

Poster (2017, September 20)

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See detailRegional scale simulation of the forest resources evolution in Southern Belgium (Wallonia)
Perin, Jérôme ULiege; Lejeune, Philippe ULiege; Hebert, Jacques ULiege

Conference (2017, September 20)

The availability of forest resources is directly affected by forest composition and structure changes that can regularly occur in the context of intensive silviculture and plantation of fast-growing tree ... [more ▼]

The availability of forest resources is directly affected by forest composition and structure changes that can regularly occur in the context of intensive silviculture and plantation of fast-growing tree species. Since 2000, the total area covered by Norway spruce plantations has decreased by an estimated 25% in Southern Belgium (Wallonia), which is especially worrying as they yield almost half of the total timber volume of the region. In order to predict the evolution of our forest resources, we first used aerial photographic interpretation to update the data of the permanent regional inventory and provide a more accurate assessment of the current resources of Wallonia. We then developed harmonized distance independent growth and management models for the three most planted softwood species of Wallonia : Norway spruce (Picea abies), Douglas-fir (Pseudotsuga menziensii) and larches (Larix sp.). These models were then implemented in a simulation software that can operate at a regional scale. This presentation introduces our methodology, the operating of our simulator, our current progress to adapt it for other stand structures and compositions and examples of carried out simulations. [less ▲]

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See detailLegitimating innovation by foreign traditions: the case of the Roman Republican divination
Berthelet, Yann ULiege

Conference (2017, September 20)

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See detailModel for the response of superconducting/ferromagnetic structures subjected to crossed fields
Vanderheyden, Benoît ULiege; Fagnard, Jean-François ULiege; Hogan, Kevin ULiege et al

Poster (2017, September 20)

Bulk (RE)BCO samples can be used as efficient permanent magnets with trapped magnetic flux densities of a few teslas at 77 K. However, their magnetization may decay over time when subjected to time ... [more ▼]

Bulk (RE)BCO samples can be used as efficient permanent magnets with trapped magnetic flux densities of a few teslas at 77 K. However, their magnetization may decay over time when subjected to time-varying parasitic fields perpendicular to the initial trapped flux density. In this work, we consider hybrid structures made of superconducting pellets and soft ferromagnetic rings or disks and investigate numerically how their magnetization varies under such crossed-field excitations. We consider a finite-element model in the A-V formulation, which is developed for both the full 3D configuration of the system and for a computationally lighter 2D approximation. The models provide the volumic distribution of current densities, the field lines, and the magnetization of the system, and the latter is compared to experimental measurements obtained with a bespoke magnetometer. A critical assessment is made outlining the advantages and limitations of the 2D approach. It is demonstrated that the ferromagnetic material helps in increasing the initial trapped field and in reducing the crossed-field effects. For the case of a single ferromagnetic disk put on top of the superconducting pellet, we study the dependence of the initial magnetization with respect to the disk thickness and the saturation field of the ferromagnetic material, and discuss the resulting optimal thickness. We also suggest different hybrid structures made of one superconducting pellet and one or several ferromagnetic disks or rings, and show numerically that a compromise is to be found between the maximum level of induction which can be reached and the improved protection against crossed-field effects. [less ▲]

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See detailÉmile de LAVELEYE (1822-1892) et le « bon » gouvernement
Grandjean, Geoffrey ULiege

Conference (2017, September 20)

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See detailThe Vedic Consecration and the Birth of the Hero in Sanskrit Epic
Swennen, Philippe ULiege

Conference (2017, September 20)

When they give birth to these heros, Arjuna's mother and Râma's mother are both compared to the Vedic goddess Aditi. This suggests that the author of the Mahâbhârata was comparing Arjuna to a Vedic ... [more ▼]

When they give birth to these heros, Arjuna's mother and Râma's mother are both compared to the Vedic goddess Aditi. This suggests that the author of the Mahâbhârata was comparing Arjuna to a Vedic sacrificer, which was perfectly clear for the author of the Râmâyana inspired by the Mahâbhârata. [less ▲]

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See detailBreed fast, die young - Demography of a Neotropical fossorial frog
Székely, Diana ULiege; Székely, Paul; Stănescu, Florina et al

Poster (2017, September 19)

Information regarding age- and size-related parameters is of paramount importance both to understanding the life-history of populations, and for designing effective conservation strategies; however, such ... [more ▼]

Information regarding age- and size-related parameters is of paramount importance both to understanding the life-history of populations, and for designing effective conservation strategies; however, such base-line data lacks for many species, especially for those inhabiting tropical habitats. Using skeletochronology, we provide the first detailed information regarding the demography of the Pacific horned frog, Ceratophrys stolzmanni, a vulnerable, fossorial amphibian, that lives in the Tumbesian dry-forests of Ecuador. The species shows an intense growth rate during the first activity season, both before and after metamorphosis. Sexual maturity is achieved by both sexes before the first year of life, after which growth rates abruptly decrease. Females are on average larger, but not older, than males, mean age being two years in both sexes. The rapid sexual maturation is associated with a short life-span, the observed maximum longevity being three years in males and four years in females. The short reproductive life-span, which offers few mating opportunities, might have important implications for the conservation of this species, that can be especially at risk in the case of prolonged droughts expected to affect its habitat. [less ▲]

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See detailIdentification and quantitation of intact virus-like particles of human papillomavirus (HPV-VLP) using capillary electrophoresis
Bettonville, Virginie ULiege; Nicol, Jérôme; Furst, Tania et al

Conference (2017, September 19)

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See detailThe Cassini-Huygens mission: tale of a 13-year journey in the Saturnian system
Palmaerts, Benjamin ULiege

Conference (2017, September 19)

On the 15th of September 2017, the Cassini spacecraft will plunge into the atmosphere of Saturn, making the end of the successful Cassini-Huygens mission. During this unprecedented mission, Cassini will ... [more ▼]

On the 15th of September 2017, the Cassini spacecraft will plunge into the atmosphere of Saturn, making the end of the successful Cassini-Huygens mission. During this unprecedented mission, Cassini will have spent 13 years around Saturn, achieving almost 300 orbits around the planet and continuously collecting observations of Saturn, its rings, moons and space environment. In this talk, after a short introduction about the genesis of the Cassini mission, I will give a review of all the important results of the mission. The dynamics of Saturn's atmosphere and magnetosphere will be discussed, as well as the discoveries about the evolution of the rings. An important part of the presentation will be also devoted to the moons Titan and Enceladus which both exhibit striking characteristics. [less ▲]

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See detailChallenges in the determination of amyloid oligomeric species by two electrophoretic techniques
Napp, Aurore ULiege; Houbart, Virginie ULiege; Demelenne, Alice ULiege et al

Poster (2017, September 18)

Parkinson’s disease is a frequent degenerative disorder, and for the moment the diagnosis is mainly clinical. When the first symptoms appear, loss of more than 70% of the dopaminergic cells already ... [more ▼]

Parkinson’s disease is a frequent degenerative disorder, and for the moment the diagnosis is mainly clinical. When the first symptoms appear, loss of more than 70% of the dopaminergic cells already occurred. Knowing that, it is of high interest to have one (or more) reliable biomarker(s) at our disposal to diagnose Parkinson before the first symptoms appear. Alpha-synuclein (aSyn) is a protein physiologically expressed at high level by neuronal cells, under a monomeric form. This protein would play a critical role in the development of the disease because under certain conditions, aSyn is capable of self-assembly to form fibrils like those found in Lewy bodies. Other intermediate soluble forms like dimers and oligomers are also formed. As these forms seems to be the toxic species, they are the center of many attentions. The quantification of each form would be a great help, but for the moment only the total forms (of monomeric or oligomeric) can be quantified. In this study, aSyn oligomers were generated after optimization of incubation conditions (pH, temperature, agitation, …). Then, different approaches were investigated to detect and follow the different species formed during the aggregation. We analyzed the oligomers by capillary gel electrophoresis (CGE) and SDS-PAGE. We found that capillary gel electrophoresis is a promising automated technique to analyze aSyn oligomers, due to the fact that it separates the aggregates according to their size, like the SDS-PAGE, but with more advantages. To gain sensitivity and selectivity by CGE, we used a laser-induced fluorescence detector. As aSyn do not have a native fluorescence, we derivatized it. After careful screening and optimization of various derivatization reagents, we could quantify with high sensitivity aSyn oligomers by CGE-LIF. We realized different calibration curves, and we had promising results that will allow us to quantify the different aSyn oligomeric forms in biological fluids. [less ▲]

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See detailA SPRAY DRYING METHOD FOR THE PREPARATION OF Na2FePO4F/CB AND Na2FePO4F/CNT COMPOSITES CATHODE FOR LITHIUM-ION BATTERIES
Mahmoud, Abdelfattah ULiege; Berardo, Loris ULiege; Brisbois, Magali et al

Poster (2017, September 18)

Fluorophosphates are considered among the most interesting series of cathode material for Li/Na-ion batteries1. Na2FePO4F (space group Pbcn), with its layered structure and two-dimensional pathways for ... [more ▼]

Fluorophosphates are considered among the most interesting series of cathode material for Li/Na-ion batteries1. Na2FePO4F (space group Pbcn), with its layered structure and two-dimensional pathways for facile Na+/Li+ transport, exhibits minimal structural changes upon reduction/oxidation. The average working voltage is 3.3 V vs. Li/Li+. Intercalation/deintercalation results in a volume change of only 3.7%. However, one of the key drawbacks of Na2FePO4F electrodes is their low intrinsic electronic conductivity. In order to study the effect of the carbon black and carbon nanotubes on the electrochemical performance of Na2FePO4F cathode material for lithium-ion batteries, Na2FePO4F, Na2FePO4F/CB and Na2FePO4F/CNT were prepared by a spray-drying method with different ratios of CB and CNT (10 and 20%). The crystal and local structure were analyzed by XRD and Mössbauer spectroscopy. The electrochemical properties were studied by galvanostatic cycling in lithium cells. The electrochemical performance is markedly better in the case of Na2FePO4F/CNT (20 wt%), with specific capacities of about 100 mAh/g (Na2FePO4F/CNT) at C/4 rate2 vs. 50 mAh/g for Na2FePO4F/CB. The characterization of Na2FePO4F/CB particles by electron microscopy revealed a carbon-poor surface and a good carbon dispersion for Na2FePO4F/CNT particles attributed to better diffusion of carbon nanotubes in the droplets during drying. References : 1-N. Eshraghi, S. Caes, A. Mahmoud, R. Cloots, B. Vertruyen, F. Boschini, Electrochim. Acta, 228 (2017) 319–324. 2-M. Brisbois, S. Caes, M-T. Sougrati, B. Vertruyen, A. Schrijnemakers, R. Cloots, N. Eshraghi, R-P. Hermann, A. Mahmoud, F. Boschini, Solar Energy Materials & Solar Cells 148 (2015) 67-72. [less ▲]

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See detailChildren motor skills competencies in Wallonia: descriptive data and testing battery discrimination analysis
Jidovtseff, Boris ULiege; Vandeloise, Vérane; De Sousa Morgado, Liliane ULiege et al

Conference (2017, September 16)

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See detailFatigue resistant designs using stress-based topology optimization
Collet, Maxime ULiege; Bauduin, Simon ULiege; Fernandez Sanchez, Eduardo Felipe ULiege et al

Conference (2017, September 15)

Fatigue is an important mode of failure in mechanical engineering and accounting for it as soon as the early stage of design using topology optimization sounds primordial. Structures undergoing high-cycle ... [more ▼]

Fatigue is an important mode of failure in mechanical engineering and accounting for it as soon as the early stage of design using topology optimization sounds primordial. Structures undergoing high-cycle fatigue can be described by the stress-based approach and then a stress-based topology optimization framework, which has received great interest since almost 20 years because of the innovative designs that can be achieved to answer strength requirements, can be used. Literature reports many good results for shape optimization [Mrzyglod & Zielinsky(2006)] whereas in the eld of topology optimization several authors have shown that considering fatigue in an optimization framework leads to more relevant solutions where fluctuating loads are involved [Holmberg E.(2015), Collet et al(2016), Sv ard(2015)]. The good behaviour of the implementation of an advanced fatigue criterion, i.e. the multiaxial Dang Van criterion [Dang Van et al(1989)] is first investigated in the framework of a density-based topology optimization problem. The choice of this fatigue criterion is justifed by its good applicability in automotive or aeronautic industry as well as its relevancy with respect to experimental results. We present the sensitivity analysis with stress constraints and present some classical benchmarks to illustrate the behaviour of the optimized solution. In a second time, the fatigue resistance is introduced in the well-known microstructural design [Sigmund (2000)] also know as architectured material design which are now considered in mechanical engineering because of their manufacturability thanks to additive manufacturing processes. Ensuring the fatigue resistance of the cellular material will by extension ensure the structural integrity of the overall structure itself. The optimization is performed by using the MMA optimizer [Svanberg(1987)] whereas the singularity phenomenon of the stress constraints is circumvented by using the qp-relaxation [Bruggi(2008)]. Both types of optimization framework are evaluated in term of their numerical performances and are compared to classical results generated by a regular stress-based topology optimization. Finally, the results are 3D-printed to assess for their manufacturability. [less ▲]

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See detailChanges in a metacognitive heuristic in amnesia
Thonnard, Adeline ULiege; Geurten, Marie ULiege; Willems, Sylvie ULiege

Poster (2017, September 15)

Amnesic patients rely predominantly on familiarity for recognition. This familiarity is thought to be based on processing fluency. However whether amnesic patients use normally this metacognitive ... [more ▼]

Amnesic patients rely predominantly on familiarity for recognition. This familiarity is thought to be based on processing fluency. However whether amnesic patients use normally this metacognitive heuristic is not yet known. We used the Jacoby and Whitehouse (1989)’s illusion paradigm with 8 patients with severe memory impairments and 16 matched control. We found a fluency effect, with more “old” responses being given to matched-prime test words than to mismatched-prime test words. In addition, we replicated the effect of modality (Westerman et al., 2002) in the control group. The fluency induced the recognition illusion, but only when there was a match between study and test sensory modality. However, this modality effect seems limited to control participants. Amnesic patients seem unable to disregard fluency when there was a shift in the sensory modality of the study and test stages. Overall, these findings support the notion that amnesic patients did not modulate their use of the fluency heuristic in situations where fluency is judged non-diagnostic of prior exposure by healthy participants. On the whole, these findings suggest that processing fluency can constitute a cue for recognition decision in amnesia. However, this influence is not direct and is subject to metamemorial belief changes. [less ▲]

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See detailSharing good practices in physical education to promote physical activity, wellness and health
Bonni, Jérémy ULiege; Cloes, Marc ULiege

Poster (2017, September 15)

The Wallonia-Brussels Federation is about to overhaul its education system, which will directly affect teacher training. Under the “Pact for Excellence in Education”, a group of experts – the Consortium ... [more ▼]

The Wallonia-Brussels Federation is about to overhaul its education system, which will directly affect teacher training. Under the “Pact for Excellence in Education”, a group of experts – the Consortium “Physical Activities, Well-Being and Health” – drawn from the 12 French-speaking institutions training PE teachers (universities and colleges) has been mandated by the Ministry of Education to design devices and tools aiming at implementing the new common core curriculum that is under construction. Good practices have been identified then described in information sheets common to the different consortiums of the PEE and listed in a table that cross-references the 6 dimensions of physical activity at school (Snyers et al., 2014) and the 20 objects of teaching-learning in health education (Turcotte et al., 2011). These good practices are meant to be shared later within a community of practice. This paper provides a description of one of these information sheets in order to illustrate the methodology applied in this project. [less ▲]

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See detailRuralité et mondialisation dans l'oeuvre de Josef Winkler
Neelsen, Sarah ULiege

Conference (2017, September 15)

Une œuvre à ce point enracinée dans le paysage, la culture et la langue de l’Autriche semblait peu propice à intégrer les bouleversements de l’ordre mondial après 1989 et son auteur bel et bien enfermé ... [more ▼]

Une œuvre à ce point enracinée dans le paysage, la culture et la langue de l’Autriche semblait peu propice à intégrer les bouleversements de l’ordre mondial après 1989 et son auteur bel et bien enfermé dans une certaine tradition nationale. Pourtant à partir de 1996, les récits de voyage, journaux intimes et romans sur l'Inde se multiplient. La mondialisation semble donc bien avoir eu un impact profond sur son travail et l'étude approfondie du roman Roppongi montre comment se construisent des effets de résonance entre rituels funéraires hindous et catholiques. Cette communication analyse les différences entre interculturalité et mondialisation, lieux et non-lieux et conclut sur la tension entre la mobilité des corps et l'obsession de l'image fixe. [less ▲]

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See detailPublic spaces, Mediation, and Scales of Visibility : the case of the representation of rural workers in post-Mao China
Florence, Eric ULiege

Conference (2017, September 15)

Woven into complex social, political and cultural fields, migrants’ experiences and narrations of mobility and of how they fare outside their hometown, of how they are more or less successful in their ... [more ▼]

Woven into complex social, political and cultural fields, migrants’ experiences and narrations of mobility and of how they fare outside their hometown, of how they are more or less successful in their attempts to negociate social hierarchies and the formation of their identities often closely articulate with major social norms and values, as well as with processes of state formation. In this contribution, I argue that in studying how migrants’ agency are at once enabling and shaped by structural forces there is a need to focus on processes of “mediation” as these processes enable to think seriously the relationship between institutions/organisations , people and meanings . Focusing on processes of mediation enables to deal with how people’s subjectivities and agency are shaped in complex and never totalizing ways by the very institutions (medias) through which they mediate their experiences. By documenting specifically how migrant workers in post-Mao China mediate their experiences of social hierarchies and social mobility via their engagement with a specific form of media (popular literature), I stress the relevance of intertextuality, of the notion of “genre” (Bakhtin), of “publics” and draw from Roseberry’s use of “hegemonic frameworks” for whom hegemony is helfpful to study “the ways in which the words, images, symbols, forms, organizations, institutions, and movements used by subordinate populations to talk about, understand, confront, accommodate themselves to, or resist their domination are shaped by the process of domination itself”. For Roseberry, “What hegemony constructs, then is not a shared ideology, but a common material and meaningful framework for living through, talking about, and acting upon social orders characterized by domination”. According to this approach, establishing such a framework rests on “prescribed forms of procedures” or “prescribed forms for expressing both acceptance and discontent”, as well as anger, disillusion, aspirations, desires, etc. (Roseberry, 1994, p. 360-361). [less ▲]

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See detailCoronagraphy and Interferometry: Imaging the sky at high contrast and high-angular resolution
Defrere, Denis ULiege; Absil, Olivier ULiege

Conference (2017, September 15)

Short overview of the main activities related to exoplanet imaging at the STAR Institute

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See detailHow classroom teachers do take the ‘Physical Activity Pauses at School’ (PAPS)? A project implemented in Wallonia
Cloes, Marc ULiege; Cloes, Stéphanie

Conference (2017, September 15)

In Wallonia, special efforts are needed in order to respect the international recommendations on physical activity in youth. School is definitely considered as a central pillar in the promotion of an ... [more ▼]

In Wallonia, special efforts are needed in order to respect the international recommendations on physical activity in youth. School is definitely considered as a central pillar in the promotion of an active lifestyle. The aim of this study was to analyze the implementation process of daily activity breaks called ‘Physical Activity Pause at School’ (PAPS) in 6 primary schools of the Liege area. 23 classroom teachers were involved. They had to propose at least one PAPS/day during the 15-16 school year. Diary, questionnaires, focus groups and interviews were used for data collecting. Two thirds of the subjects continued until the end. The videos were not systematically used. Four teachers’ profiles were identified: Innovators, Invested, Careful, and Disengaged. 12 factors facilitating or limitating the involvement of the teachers have been analyzed. The study comes to a model of concrete actions to respect in order to increase the chances of success in the implementation of such project. [less ▲]

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