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See detailLe Paléolithique supérieur de la Moldavie
Noiret, Pierre ULiege

in Anthropologie (L') (2004), 108(3-4, JUL-OCT), 425-470

Upper Palaeolithic lithic industries in Moldavia primarily can be attributed to traditional culture's known across Europe: (Aurignacian and Gravettian. followed by Epigravettian). However, they coexsist ... [more ▼]

Upper Palaeolithic lithic industries in Moldavia primarily can be attributed to traditional culture's known across Europe: (Aurignacian and Gravettian. followed by Epigravettian). However, they coexsist with other industries marked by the presence of bifacially retouched tools, in reportedly early contexts, but which are poorly dated and often heterogeneous. Such industries, considered in the literature as belonging to three of four vaguely defined cultural traditions, most probably should be grouped in a single cultural entity, the Prut culture. The main occupations can, with our current state of knowledge, be classified in a well-supported and well-dated regional chronostratigraphic scheme; they are attributed to Typical Aurignacian (33 000-29 000 BP), Gravettian (29 500-23 000 BP), Early Epigravettian (20 000-17 000 BP) and Late Epigravettian (13 500-11 000 BP). Data from Moldavia also are relevant to broad cultural phenomena: the Aurignacian exploration of a territory extending from to the centre of the Russian plain and to the northern foothills of the Ural (beginning at 33 000 BP), the multiple geographic origins of the Gravettian (around 30 000 BP), the presence of non-Aurignacian and non-Gravettian lithic industries (with bifacial tools, likely around 27 000-26 000 13P), the reappearance of technological characteristics of "Aurignacoid" aspect (from 21000 13P), and the massive return to a tradition with backed tools (from 20 000 BP). The data from Moldavia plays a role ill a broad palaeohistory, at a continental scale. (C) 2004 Elsevier SAS. Tous droits reserves. [less ▲]

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See detailCardiomyocyte-restricted overexpression of endothelial nitric oxide synthase (NOS3) attenuates beta-adrenergic stimulation and reinforces vagal inhibition of cardiac contraction.
MASSION, Paul ULiege; Dessy, Chantal; Desjardins, Fanny et al

in Circulation (2004), 110(17), 2666-72

BACKGROUND: In the heart, nitric oxide synthases (NOS) modulate cardiac contraction in an isoform-specific manner, which is critically dependent on their cellular and subcellular localization. Defective ... [more ▼]

BACKGROUND: In the heart, nitric oxide synthases (NOS) modulate cardiac contraction in an isoform-specific manner, which is critically dependent on their cellular and subcellular localization. Defective NO production by NOS3 (endothelial NOS [eNOS]) in the failing heart may precipitate cardiac failure, which could be reversed by overexpression of NOS3 in the myocardium. METHODS AND RESULTS: We studied the influence of NOS3 in relation to its subcellular localization on the function of cardiomyocytes isolated from transgenic mice overexpressing NOS3 under the alpha-myosin heavy chain promoter (NOS3-TG). Immunoblot analysis demonstrated moderate (5-fold) NOS3 overexpression in cardiomyocytes from NOS3-TG heterozygotes. Caveolar localization of transgenic eNOS was demonstrated by immunofluorescence, coimmunoprecipitation with caveolin-3, sucrose gradient fractionation, and immunogold staining revealed by electron microscopy. Compared with wild-type littermate, contractility of NOS3-TG cardiomyocytes analyzed by videomicroscopy revealed a lower incidence of spontaneous arrhythmic contractions (n=32, P<0.001); an attenuation of the beta-adrenergic positive inotropic response (isoproterenol, 10(-7) mol/L: 62.1+/-7.8% versus 90.8+/-8.0% of maximum Ca2+ response; n=10 to 17; P<0.05); a potentiation of the muscarinic negative chronotropic response (carbamylcholine, 3.10(-8) mol/L: -63.9+/-14% versus -27.7+/-5.6% of basal rate; n=8 to 10; P<0.05), confirmed by telemetry in vivo; and an attenuation of the accentuated antagonism of beta-adrenergically stimulated contraction (-14.6+/-1.5% versus -3.5+/-1.5; n=7 to 11; P<0.05). Cardiomyocyte NOS inhibition reversed all 4 effects (P<0.05). CONCLUSIONS: Moderate overexpression of NOS3, targeted to caveolae in murine cardiomyocytes, potentiates the postsynaptic muscarinic response and attenuates the effect of high concentrations of catecholamines. Cardiomyocyte NOS3 may represent a promising therapeutic target to restore the sympathovagal balance and protect the heart against arrhythmia. [less ▲]

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See detailLe BLV: un modele d'etude pour les leucemies humaines.
Willems, Luc ULiege

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2004), 159(10-12),

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See detailVigny : poète antique ou moderne ?
Durand, Pascal ULiege

in Bulletin de l’Association des Amis d’Alfred de Vigny (2004), 33

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See detailInventaire forestier de gestion : proposition d'un cadre méthodologique et technique
Lejeune, Philippe ULiege; Rondeux, Jacques ULiege

in Forêt Wallonne (2004), (73), 22-29

Confronté à des sollicitations de plus en plus nombreuses envers la forêt, le gestionnaire forestier doit pouvoir disposer d’informations adaptées à la complexité des analyses qu’il est amené à réaliser ... [more ▼]

Confronté à des sollicitations de plus en plus nombreuses envers la forêt, le gestionnaire forestier doit pouvoir disposer d’informations adaptées à la complexité des analyses qu’il est amené à réaliser. Les progrès récents en matière de cartographie donnent accès à une information très précieuse. L’inventaire forestier reste cependant l’outil le plus adapté pour une description, tant qualitative que quantitative, des peuplements et de leurs diverses composantes. Ces inventaires ne peuvent cependant plus se limiter au simple recensement du matériel sur pied présent au sein des différentes parcelles d’une propriété. [less ▲]

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See detailInterés medicinal de las comunidades vegetales de la comarca de La Safor (Valencia)
Martínez-Solís, Isabel; Sanahuja, Maria A.; Moreno, Lucrecia et al

in Revista de Fitoterapia (2004), 4(2), 165-168

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See detailLe choix de la couleur en prothese fixe: quelle marche a suivre pour un resultat fiable?
Van Heusden, Alain ULiege; Mainjot, Amélie ULiege

in Revue Belge de Médecine Dentaire = Belgisch Tijdschrift voor Tandheelkunde (2004), 59(1), 43-56

The creation of a perfectly-matched esthetic fixed restoration is undeniably one of the most difficult challenges in modern dentistry. The final outcome depends on several essential steps: the use of an ... [more ▼]

The creation of a perfectly-matched esthetic fixed restoration is undeniably one of the most difficult challenges in modern dentistry. The final outcome depends on several essential steps: the use of an appropriate light source, the accurate analysis and correct evaluation of patient's teeth parameters (morphology, colour, surface texture,...), the clear and precise transmission of this data to the laboratory and the sound interpretation of it by a dental technician who masters esthetic prosthetic techniques perfectly. The purpose of this paper was to give a reproducible clinical method to the practitioner in order to achieve a reliable dental colorimetric analysis. [less ▲]

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See detailImpaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3
Sokolow, S.; Manto, M.; Gailly, P. et al

in Journal of Clinical Investigation (2004), 113

We produced and analyzed mice deficient for Na/Ca exchanger 3 (NCX3), a protein that mediates cellular Ca(2+) efflux (forward mode) or Ca(2+) influx (reverse mode) and thus controls intracellular Ca(2 ... [more ▼]

We produced and analyzed mice deficient for Na/Ca exchanger 3 (NCX3), a protein that mediates cellular Ca(2+) efflux (forward mode) or Ca(2+) influx (reverse mode) and thus controls intracellular Ca(2+) concentration. NCX3-deficient mice (Ncx3(-/-)) present a skeletal muscle fiber necrosis and a defective neuromuscular transmission, reflecting the absence of NCX3 in the sarcolemma of the muscle fibers and at the neuromuscular junction. The defective neuromuscular transmission is characterized by the presence of electromyographic abnormalities, including low compound muscle action potential amplitude, a decremental response at low-frequency nerve stimulation, an incremental response, and a prominent postexercise facilitation at high-frequency nerve stimulation, as well as neuromuscular blocks. The analysis of quantal transmitter release in Ncx3(-/-) neuromuscular junctions revealed an important facilitation superimposed on the depression of synaptic responses and an elevated delayed release during high-frequency nerve stimulation. It is suggested that Ca(2+) entering nerve terminals is cleared relatively slowly in the absence of NCX3, thereby enhancing residual Ca(2+) and evoked and delayed quantal transmitter release during repetitive nerve stimulation. Our findings indicate that NCX3 plays an important role in vivo in the control of Ca(2+) concentrations in the skeletal muscle fibers and at the neuromuscular junction [less ▲]

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See detailCase studies in measurement of random incidence scattering coefficients
Vorländer, Michael; Embrechts, Jean-Jacques ULiege; De Geetere, Lieven et al

in Acta Acustica United With Acustica (2004), 90(5, SEP-OCT), 858-867

In this work measurements of random-incidence scattering coefficients in three laboratories are compared. The sample geometry is sinusoidal. These surfaces are geometrically identical, but they were ... [more ▼]

In this work measurements of random-incidence scattering coefficients in three laboratories are compared. The sample geometry is sinusoidal. These surfaces are geometrically identical, but they were constructed in different scales. So far, measurements of this kind were performed only in scale models. Using turntables in real sample size was hardly considered possible. One result of general importance is that measurements are indeed possible in real-scale reverberation rooms with turntables of 3 m diameter. There are only small differences between the real-scale and model-scale results. Some variations of the standard procedure were tested and the uncertainties identified: mounting of the sample, connection or sealing between sample and base plate, way of rotating the sample, air absorption and time variances. The results presented can be regarded as guidelines for application of ISO/DIS 17497-1. [less ▲]

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See detailSynthesis of Pyrazolylpyridine Derivatives Bearing a Tethered Alkoxysilyl Group.
Sacco Luigi; Lambert, Stéphanie ULiege; Pirard, Jean-Paul ULiege et al

in Synthesis (2004), 5

A synthesis of a new serie of trimethoxysilyl-tethered N-substituted 3,5-dialkylpyrazolylpyridines is reported. The silyl spacers allow the grafting of ligands onto silica via formation of covalent bonds ... [more ▼]

A synthesis of a new serie of trimethoxysilyl-tethered N-substituted 3,5-dialkylpyrazolylpyridines is reported. The silyl spacers allow the grafting of ligands onto silica via formation of covalent bonds as well as the synthesis of xerogels. [less ▲]

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See detailCoupled mechanical-electrostatic FE-BE analysis with FMM acceleration
V Sabariego, Ruth ULiege; Gyselinck, Johan; Dular, Patrick ULiege et al

in COMPEL (2004), 23(4), 876-884

This paper deals with the coupled mechanical-electrostatic analysis of a shunt capacitive MEMS switch. The mechanical and electrostatic parts of the problem are modelled by the FE and BE methods ... [more ▼]

This paper deals with the coupled mechanical-electrostatic analysis of a shunt capacitive MEMS switch. The mechanical and electrostatic parts of the problem are modelled by the FE and BE methods, respectively. The fast multipole method is applied to reduce the storage requirements and the computational cost of the BE electrostatic model An adaptive truncation expansion of the 3D Laplace Green function is employed The strong interaction between the mechanical and electrostatic systems is considered iteratively. [less ▲]

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See detailComplementary two-dimensional finite element formulations with inclusion of a vectorized Jiles-Atherton model
Gyselinck, Johan; Vandevelde, Lieven; Melkebeek, Jan et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2004), 23(4), 959-967

This paper deals with the magnetic vector and scalar potential formulation for two-dimensional (2D)finite element (FE) calculations including a vector hysteresis model, namely a vectorized Jiles-Atherton ... [more ▼]

This paper deals with the magnetic vector and scalar potential formulation for two-dimensional (2D)finite element (FE) calculations including a vector hysteresis model, namely a vectorized Jiles-Atherton model. The particular case of a current-free FE model with imposed fluxes and magnetomotive forces is studied. The non-linear equations are solved by means of the Newton-Raphson method, which leads to the use of the differential reluctivity and permeability tensor. The proposed method is applied to a simple 2D model exhibiting rotational flux, viz the T-joint of a three-phase transformer. [less ▲]

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See detailCharacterizing Simpler recognizable sets of integers
Rigo, Michel ULiege

in Studia Logica (2004), 76

For a given numeration system U, a set X of integers is said to be U-star-free if the language of the normalized U-representations of the elements in X is star-free. Adapting a result of McNaughton and ... [more ▼]

For a given numeration system U, a set X of integers is said to be U-star-free if the language of the normalized U-representations of the elements in X is star-free. Adapting a result of McNaughton and Papert, we give a first-order logical characterization of these sets for various numeration systems including integer base systems and the Fibonacci system. For k-ary systems, the problem of the base dependence of this property is also studied. Finally, the case of k-adic systems is developed. [less ▲]

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See detailLipids metabolism and hyperlipidaemia in the dog
Jeusette, Isabelle; Istasse, Louis ULiege; Diez, Marianne ULiege

in Annales de Médecine Vétérinaire (2004), 148(2), 79-89

This synthesis aims to summarize lipids metabolism in the dog. The different aetiology and diagnostic of primary or secondary hyperlipidaemia in dog are reviewed. The nutritional treatment and more ... [more ▼]

This synthesis aims to summarize lipids metabolism in the dog. The different aetiology and diagnostic of primary or secondary hyperlipidaemia in dog are reviewed. The nutritional treatment and more particularly the use of dietary fibres are discussed. [less ▲]

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See detailRecombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors
Scippo, Marie-Louise ULiege; Argiris, Catherine; Van de Weerdt, Cécile ULiege et al

in Analytical and Bioanalytical Chemistry (2004), 378(3), 664-669

This work reports the binding capacity of various chemicals (so-called endocrine disruptors) to recombinant human steroid receptors (hERalpha, hPR and hAR). The tested chemicals are organochlorine ... [more ▼]

This work reports the binding capacity of various chemicals (so-called endocrine disruptors) to recombinant human steroid receptors (hERalpha, hPR and hAR). The tested chemicals are organochlorine insecticides (DDT and its metabolites, methoxychlor, aldrin, dieldrin, chlordecone, lindane, trichlorobenzene), estrogenic insecticides (endosulfan, toxaphene, nonachlor), herbicides (alachlor and atrazine), fungicides (benomyl and vinclozolin), industrial chemicals (nonylphenol, bisphenol A, diphenylphtalate), antioxidants (butylated hydroxyanisol) and some phytoestrogens. Except for phytoestrogens, most of the tested chemicals (DDT and its metabolites, aldrin, alpha- and beta-endosulfan, toxaphen, trans-nonachlor) show higher affinities for hPR than for hERalpha, indicating that the interaction with the progesterone receptor could contribute to the endocrine-disrupting effects imputed to these chemicals. We propose to use binding assays using recombinant human steroid receptors as screening tools for the detection of endocrine disruptors in various samples. [less ▲]

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See detailCette île est mienne... et tu me l'as prise: Shakespeare au XXe siècle
Maes-Jelinek, Hena ULiege

in Bulletin de la Classe des Lettres et des Sciences Morales et Politiques (2004), 15(1-6), 23-41

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See detailSynopsis des dermatomycoses invasives chez l'immunodéprimés.
Quatresooz, Pascale ULiege; Arrese Estrada, Jorge ULiege; Pierard, Gérald ULiege

in Revue de l’Association Belge des Technologues de Laboratoire = Tijdschrift van de Belgische Vereniging van Laboratoriumtechnologen (2004), 31

The immune system plays a prominent role in the defense against a wide variety of pathogen fungi. Thus, the immunocompromised patient becomes a potential victim of mycoses originating from the skin. These ... [more ▼]

The immune system plays a prominent role in the defense against a wide variety of pathogen fungi. Thus, the immunocompromised patient becomes a potential victim of mycoses originating from the skin. These mycoses may become invasive and a fatal issue is possible. In other circumstances, the inoculation site is pulmonary or digestive, and the cutaneous lesions represent secondary localizations. [less ▲]

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See detailA complex anterior mediastinal mass: demonstration of pericardial haemangioma by dynamic MRI (2003:10b).
NCHIMI LONGANG, Alain ULiege; Ghaye, B.; Szapiro, D. et al

in European Radiology (2004), 14(1), 160-3

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See detailSustained vertebral fracture risk reduction after withdrawal of teriparatide in postmenopausal women with osteoporosis.
Lindsay, Robert; Scheele, Wim H; Neer, Robert et al

in Archives of Internal Medicine (2004), 164(18), 2024-30

BACKGROUND: Teriparatide (recombinant human parathyroid hormone [1-34]) reduces fracture risk in postmenopausal women with osteoporosis. We assessed the safety and incidence of new vertebral fractures ... [more ▼]

BACKGROUND: Teriparatide (recombinant human parathyroid hormone [1-34]) reduces fracture risk in postmenopausal women with osteoporosis. We assessed the safety and incidence of new vertebral fractures after withdrawal of teriparatide. METHODS: This study is a follow-up to the Fracture Prevention Trial (FPT), a randomized, placebo-controlled study of postmenopausal women with osteoporosis treated with teriparatide (20 or 40 microg) once daily for a mean of 18 months. More than 90% of the women remaining at the end of the FPT continued into the follow-up study (n = 1262). Patients and investigators were unblinded to original treatment group assignment. Women were treated according to standard clinical practice, including elective use of osteoporosis drugs. New vertebral fractures were determined by semiquantitative scoring of lateral thoracic lumbar spine radiographs 18 months after the end of the FPT. RESULTS: During the follow-up study, the reduction in fracture risk associated with previous treatment with teriparatide, 20 and 40 microg, was 41% (P = .004) and 45% (P = .001), respectively, vs placebo. The absolute reduction from the FPT baseline to the 18-month follow-up visit was 13% for both doses. Osteoporosis drugs were used by 47% of women during follow-up, with greater use in the former placebo group (P = .04); nevertheless, persistent fracture protection of previous teriparatide therapy was evident. Post hoc analysis also suggests that teriparatide treatment substantially reduced the increased risk of subsequent fracture in women who sustained a fracture during the FPT (P = .05). CONCLUSION: Vertebral fracture risk reduction by teriparatide administration persists for at least 18 months after discontinuation of therapy. [less ▲]

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See detailExploitation of electronic medical records data in primary health care. Resistances and solutions. Study in eight Walloon health care centres.
Vanmeerbeek, Marc ULiege

in Studies in Health Technology & Informatics (2004), 110

INTRODUCTION: The Electronic Medical Records (EMR), used every day for primary health care may constitute an instrument for gathering locally usable data to improve the quality of care and, on a larger ... [more ▼]

INTRODUCTION: The Electronic Medical Records (EMR), used every day for primary health care may constitute an instrument for gathering locally usable data to improve the quality of care and, on a larger scale, be a basis of epidemiological data. In spite of a policy of promotion of the EMR made by the Federation of French-speaking Belgian "Medical Houses", its use remains very marginal. METHODS: Eight Medical Houses, motivated by computerization of medical records have been met. Quantitative indicators of use of the EMR have been assessed. A qualitative assessment of the resistances to computerization, and solutions which can be brought, has been realized through the technique of the nominal group. RESULTS: The use of the EMR remains slight, allowing for exceptions. The proposed solutions could be put together in 5 categories : ethics, training, search for sense, practice and interdisciplinarity. DISCUSSION: The practitioners are willing to computerize if they get immediate advantages (knowledge of their patients and their team operating). They expressed the need of having a tool easy to use, that doesn't make them lose time and that has respect for their specificity of work and organization (interdisciplinary and self-managed teams). They expressed the need of an external support, under the form of adapted training and supervision for the data management. Ethical concerns (security, data transfer, place of the computer in the relationship with the patient) are surprisingly not present enough. [less ▲]

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See detailGlucosinolates in isano (Tropaeolum tuberosum) tubers: qualitative and quantitative content and changes after maturity
Ramallo, R.; Wathelet, Jean-Paul ULiege; Le Boulenge, E. et al

in Journal of the Science of Food and Agriculture (2004), 84(7), 701-706

Six varieties of isano (Tropaeolum tuberosum), an Andean edible tuber, were analysed. The aim was to characterise qualitatively and quantitatively their content of glucosinolates and to determine ... [more ▼]

Six varieties of isano (Tropaeolum tuberosum), an Andean edible tuber, were analysed. The aim was to characterise qualitatively and quantitatively their content of glucosinolates and to determine concentration changes of these compounds upon delayed harvest. Additionally, exploratory assays were carried out on the effect of postharvest cold storage of the tubers as well as of a drying process imposed on blanched tuber slices. Only one glucosinolate (p-methoxybenzyl glucosinolate) was found in the six domestic varieties analysed. Its concentration varied between 36.5 and 90.0 mumolg(-1) dry matter. This range is relatively high when compared with other edible glucosinolate-containing vegetables. 'Dark' coloured tuber varieties showed higher levels than 'light' coloured tuber varieties at normal harvest time. Of the two varieties on which the effect of delayed harvest was studied, one showed increasing and then decreasing changes until 44 days after maturity, while the other did not show any significant change with time. Postharvest cold stored samples showed similar changes to tubers kept in soil, and glucosinolate levels in dried blanched tubers did not differ significantly from those in fresh samples. Taken together, the data indicate that the glucosinolate content of isano is highly dependent on both the variety and the time of harvest. These parameters should be taken into account when considering isano as a promising food source with medicinal properties for humans and animals, but also with possible adverse biological effects, all related to the presence of glucosinolates. (C) 2004 Society of Chemical Industry. [less ▲]

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See detailEvolution of blood parameters during weight loss in experimental obese Beagle dogs.
Diez, Marianne ULiege; Michaux, Charles ULiege; Jeusette, Isabelle et al

in Journal of Animal Physiology & Animal Nutrition (2004), 88(3-4), 166-71

The effects of weight loss on hormonal and biochemical blood parameters were measured monthly [carnitine, creatinine, urea, free T4 (fT4), total T4 (TT4), plasma alkaline phosphatases (ALP), aspartate ... [more ▼]

The effects of weight loss on hormonal and biochemical blood parameters were measured monthly [carnitine, creatinine, urea, free T4 (fT4), total T4 (TT4), plasma alkaline phosphatases (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), potassium and total proteins] or bimonthly [cholesterol, triglycerides, non-esterified fatty acids (NEFA), insulin-like growth factor I (IGF-I), glucose, insulin] in eight obese Beagles dogs fed either a high protein dry diet, DP (crude protein 47.5%, on dry matter basis) or a commercial high fibre diet, HF (crude protein 23.8%, crude fibre 23.3%). The dogs were allotted to two groups according to sex and body weight (BW) and they were respectively fed with the DP or the control HF diet during 12-26 weeks, until they reach their optimal BW. The plasma basal triglycerides and cholesterol concentrations were decreased by the two diets but the difference was only significant for the DP diet. The plasma mean NEFA concentration increased regularly over the period with the HF diet, without significant difference between the two diets. No effect of diet or weight loss was observed on plasma carnitine, urea, creatinine, ALP, AST, ALT, potassium, TT4, FT4, IGF-I, glucose and insulin. Weight loss induced a decrease in fT4 plasma concentration (p < 0.001). The high protein diet allowed a safe weight loss. [less ▲]

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See detailIl existe une corrélation entre le score "anxiété" du test de l'"Irritabilité-Dépression-Anxiété" (IDA) et la FTC chez 9 patients successifs consultant au "Centre interdisciplinaire de l'andropause"
Henrard, Noémie ULiege; Mortiniera, N.; Mormont, Christian ULiege et al

in Annales d'Endocrinologie (2004), 65(4), 335

Free testosterone correlates with anxiety but not depression and irritability

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See detailMeasurement of shrinkage and cracks associated to convective drying of soft materials by X-ray microtomography
Léonard, Angélique ULiege; Blacher, Silvia ULiege; Marchot, Pierre ULiege et al

in Drying Technology (2004), 22(7), 1695-1708

Traditionally, the measurement of shrinkage occurring during drying is performed by destructive or poorly accurate techniques such as volume displacement methods. Cracks detection and quantification are ... [more ▼]

Traditionally, the measurement of shrinkage occurring during drying is performed by destructive or poorly accurate techniques such as volume displacement methods. Cracks detection and quantification are realised either by destructive techniques or sophisticated but expensive nondestructive ones (NMR imaging). X-ray microtomography in combination with image analysis provides an accurate, nondestructive and easy to use technique to determine simultaneously shrinkage and crack extent. Results reported in this article concern drying of wastewater sludges whose management will become a real challenge in the years to come. These results show a clear relation between drying kinetics and crack development. This could be related to the development of internal diffusional limitations inducing moisture gradients and mechanical stresses leading to cracks formation. [less ▲]

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See detailA propos du deuil
Mormont, Christian ULiege

in Revue Francophone du Stress et du Trauma (2004), 4(4), 237-304

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See detailA Real-Time Grading Method Of Apples Based On Features Extracted From Defects
Leemans, Vincent ULiege; Destain, Marie-France ULiege

in Journal of Food Engineering (2004), 61(1),

This paper presents a hierarchical grading method applied to Jonagold apples. Several images covering the whole surface of the fruits were acquired thanks to a prototype grading machine. These images were ... [more ▼]

This paper presents a hierarchical grading method applied to Jonagold apples. Several images covering the whole surface of the fruits were acquired thanks to a prototype grading machine. These images were then segmented and the features of the defects were extracted. During a learning procedure, the objects were classified into clusters by k-mean clustering. The classification probabilities of the objects were summarised and on this basis the fruits were graded using quadratic discriminant analysis. The fruits were correctly graded with a rate of 73 %. The errors were found having origins in the segmentation of the defects or for a particular wound, in a confusion with the calyx end. [less ▲]

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See detailGenetic variability of von Willebrand factor and risk of coronary heart disease: the Rotterdam Study.
van der Meer, Irene M.; Brouwers, Geert-Jan; BULK, Saskia ULiege et al

in British journal of haematology (2004), 124(3), 343-7

The von Willebrand factor (VWF) may be causally associated with coronary heart disease (CHD) or merely be a marker of endothelial damage. The G allele of the -1793 C/G promoter polymorphism in the VWF ... [more ▼]

The von Willebrand factor (VWF) may be causally associated with coronary heart disease (CHD) or merely be a marker of endothelial damage. The G allele of the -1793 C/G promoter polymorphism in the VWF gene has been associated with higher plasma levels of VWF. To investigate whether VWF has a causal role in CHD, we designed a case-cohort study, including 352 subjects with CHD and a random cohort (n = 736), and prospectively examined the association of the -1793 C/G polymorphism with CHD in subjects with and without advanced atherosclerosis. All subjects were </=75 years of age and participating in the population-based Rotterdam Study. Atherosclerosis was assessed by the ankle-arm index. Among subjects with advanced atherosclerosis, heterozygous and homozygous carriers of the G allele had a 3.5 (1.2-10.2) and 1.5 (0.4-5.7) fold increased risk of CHD respectively, compared with C/C homozygotes. The hazard ratio was 2.6 (1.0-6.8) for carriers of at least one copy of the G allele versus non-carriers. No associations were found in the absence of advanced atherosclerosis. In conclusion, this study suggests that the G allele of the -1793 C/G polymorphism in the VWF gene is associated with an increased risk of CHD, but only in subjects with advanced atherosclerosis. [less ▲]

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See detailLanreotide Autogel for acromegaly: a new addition to the treatment armamentarium.
Ciccarelli, Antonio; Daly, Adrian ULiege; Beckers, Albert ULiege

in Treatments in Endocrinology (2004), 3(2), 77-81

Since their introduction into clinical practice, somatostatin analogs have been the pharmacological therapy of choice for the treatment of acromegaly. The first preparations of somatostatin analogs ... [more ▼]

Since their introduction into clinical practice, somatostatin analogs have been the pharmacological therapy of choice for the treatment of acromegaly. The first preparations of somatostatin analogs available for clinical use were administered subcutaneously two or three times daily, which was not optimal with respect to patient compliance. The introduction of long-acting formulations of somatostatin analogs has overcome this inconvenience. Lanreotide Autogel, a new viscous, supersaturated, aqueous solution of lanreotide, is available in a prefilled syringe and administered by deep subcutaneous injection every 28 days. Lanreotide Autogel has different pharmacokinetic properties from the earlier lanreotide slow-release (SR) formulation, which may account for its better tolerability. Furthermore, lanreotide Autogel is at least as efficacious as the other somatostatin analogs in lowering growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels in the majority and in restoring safe GH and age-normalized IGF-1 levels in about 50-60% of patients with acromegaly. In conclusion, lanreotide Autogel is a valuable new addition to the acromegaly treatment armamentarium. Patients receiving intramuscular lanreotide SR injections every 7-14 days can be switched to an appropriate dose of deep subcutaneous lanreotide Autogel every 28 days, without any impact on safety or loss of efficacy. [less ▲]

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See detailThe Dutch CISOE-A framework for cytology reporting increases efficacy of screening upon standardisation since 1996.
BULK, Saskia ULiege; Van Kemenade, F. J.; Rozendaal, L. et al

in Journal of clinical pathology (2004), 57(4), 388-93

AIM: To describe the effect of introducing the CISOE-A framework for reporting cervical cytology results, including changes in repeat and referral advice in the Netherlands, on the efficacy of the ... [more ▼]

AIM: To describe the effect of introducing the CISOE-A framework for reporting cervical cytology results, including changes in repeat and referral advice in the Netherlands, on the efficacy of the screening programme. Changes in the distribution of cytological results, the detection rate of cervical intraepithelial neoplasia (CIN) lesions, and the detection rate of squamous cervical carcinoma are reported. METHODS: The results of all gynaecology cytological and histological examinations, as registered in the nationwide database for histopathology and cytopathology (PALGA) from 1990 to 2000, were retrieved from seven laboratories in the greater Amsterdam area. RESULTS: After the introduction of the CISOE-A classification, cytological results with equivocal diagnoses decreased significantly from 11.3% to 2.6%, without an increase in the percentages of moderate dyskaryosis or worse. During the study period, the detection rate of histologically diagnosed high grade CIN lesions increased significantly from 4.1 to 6.4/1000 smears, whereas there was no change in the detection rates of low grade lesions or invasive cervical cancer. CONCLUSIONS: The introduction of the new CISOE-A classification system resulted in a substantial decrease of equivocal results and repeat recommendations, without a decrease in the detection rate of high grade lesions, making the screening programme more efficacious. [less ▲]

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See detailNonlinear electromagnetic modes in astrophysical plasmas with dust distributions
Verheest, F.; Cattaert, Tom ULiege

in Astronomy and Astrophysics (2004), 421(1), 17-21

A derivative nonlinear Schrodinger equation is obtained for parallel electromagnetic modes in plasmas containing polydisperse charged dust. The coefficient of the dispersive term in that equation is ... [more ▼]

A derivative nonlinear Schrodinger equation is obtained for parallel electromagnetic modes in plasmas containing polydisperse charged dust. The coefficient of the dispersive term in that equation is dominated by the dust rather than the (plasma) ions, and polydisperse dust yields a larger coefficient in absolute value than an equivalent monodisperse description. This leads to a significant broadening of the nonlinear structure due to the presence of polydisperse rather than monodisperse dust, the latter contributing in itself already to a substantial increase in the width of envelope solitons compared to dust-free plasmas. When modelling the charged dust by a power-law distribution occurring in planetary ring and other astrophysical systems, it depends very much on the power-law index whether the smaller or the larger grains are more important. For certain indices the more numerous smaller grains determine the charge and mass densities, but the larger dust dominates the linear and nonlinear dispersive effects. [less ▲]

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See detailAromatic Side-Chain Interactions In Proteins: Near- And Far-Sequence Tyr-X Pairs
Meurisse, R.; Brasseur, Robert ULiege; Thomas, Annick ULiege

in Proteins-Structure Function and Genetics (2004), 54(3), 478-90

In the present study, an extensive analysis of the aromatic Tyr-X interactions is performed on a data set of 593 PDB structures, X being Phe, His, Tyr, and Trp. The nonredundant Tyr-X pairs (2645) were ... [more ▼]

In the present study, an extensive analysis of the aromatic Tyr-X interactions is performed on a data set of 593 PDB structures, X being Phe, His, Tyr, and Trp. The nonredundant Tyr-X pairs (2645) were retained and separated by both the residue distance in the sequence and the secondary structures they bridge. Similar to the Phe-X and His-X pairs, the far-sequence Tyr-X pairs (X partner > five apart in the sequence: 74%) show comparable secondary structures and conformers for either type of X partner, in contrast with the near-sequence Tyr-X pairs (26%). As the Phe-X pairs, the near-sequence Tyr-X pairs stabilize secondary structures, mainly the alpha- helices (positions 1, 3, and 4) and the beta-strands (position 2). Like the Phe-X and His-X pairs, most far-sequence Tyr-X pairs (34%) bridge beta-strands and only 11% bridge helices. As for the Phe-X and the His-X pairs, the X partners of the far-sequence Tyr-X pairs are frequently "above" the tyrosine ring with tilted and normal rings, whereas the X partner of the near-sequence Tyr-X pairs gradually moves from the "aside" to the "above" location, together with a progressive decrease of normal and increase of parallel rings, respectively. Unlike the His-X pairs, the interactions of the hetroatom in Tyr-X pairs are only favored with a sequence position +4 and over, owing to the spatial accessibility of the heteroatom. [less ▲]

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See detailApplication of bioencapsulated proteinases and peptides for wound gealing
Markvicheva, E; Dugina, T; Grandfils, Christian ULiege et al

in Chemical Industry (2004), 58(6a), 165-175

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See detailHaematopoetic stem cell transplantation for refractory autoimmune cytopenia.
Passweg, J. R.; Rabusin, M.; Musso, M. et al

in British Journal of Haematology (2004), 125(6), 749-55

This study describes the outcome of patients receiving haematopoietic stem cell transplantation (HSCT) to treat severe refractory autoimmune cytopenia. The registry of the European Group of Blood and ... [more ▼]

This study describes the outcome of patients receiving haematopoietic stem cell transplantation (HSCT) to treat severe refractory autoimmune cytopenia. The registry of the European Group of Blood and Marrow Transplantation holds data on 36 patients receiving 38 transplants, the first transplant was autologous for 27 and allogeneic for nine patients. Patients had autoimmune haemolytic anaemia (autologous: 5; allogeneic: 2), Evans's syndrome (autologous: 2; allogeneic: 5); immune thrombocytopenia (autologous: 12), pure red cell aplasia (autologous: 4; allogeneic: 1), pure white cell aplasia (autologous: 1; allogeneic 1), or thrombotic thrombocytopenic purpura (autologous: 3). Patients had longstanding disease having failed multiple prior treatments. Among 26 evaluable patients mobilized for autologous HSCT, three died of treatment-related causes, one died of disease progression, seven were non-responders, six patients had transient responses and nine had continuous partial or complete remission. Of the seven evaluable patients receiving allogeneic HSCT, one died of treatment-related complications, one with transient response died of progressive disease and five had a continuous response. Autologous and allogeneic HSCT may induce a response in a subset of patients with autoimmune cytopenia of long duration albeit at the price of considerable toxicity. [less ▲]

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See detailLa gestion des spécificités linguistiques et culturelles dans les évaluations internationales de la lecture
Baye, Ariane ULiege

in Politiques d'Education et de Formation : Analyses et Comparaisons Internationales (2004), 11

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See detailMixture model for inferring susceptibility to mastitis in dairy cattle: a procedure for likelihood-based inference
Gianola, D.; Odegard, J.; Heringstad, B. et al

in Genetics, Selection, Evolution (2004), 36(1, JAN-FEB), 3-27

A Gaussian mixture model with a finite number of components and correlated random effects is described. The ultimate objective is to model somatic cell count information in dairy cattle and to develop ... [more ▼]

A Gaussian mixture model with a finite number of components and correlated random effects is described. The ultimate objective is to model somatic cell count information in dairy cattle and to develop criteria for genetic selection against mastitis, an important udder disease. Parameter estimation is by maximum likelihood or by an extension of restricted maximum likelihood. A Monte Carlo expectation- maximization algorithm is used for this purpose. The expectation step is carried out using Gibbs sampling, whereas the maximization step is deterministic. Ranking rules based on the conditional probability of membership in a putative group of uninfected animals, given the somatic cell information, are discussed. Several extensions of the model are suggested. [less ▲]

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See detailDistribution and characteristics of aquatic habitats of newts and yellow-bellied toads in the district of Ioannina (Epirus, Greece)
Denoël, Mathieu ULiege

in Herpetozoa (2004), 17(1/2), 49-64

The study describes the aquatic habitats and distribution of Triturus alpestris veluchiensis Wolterstorff 1935, T. carnifex macedonicus (Karaman, 1922), T. vulgaris graecus (Wolterstorff, 1905) and ... [more ▼]

The study describes the aquatic habitats and distribution of Triturus alpestris veluchiensis Wolterstorff 1935, T. carnifex macedonicus (Karaman, 1922), T. vulgaris graecus (Wolterstorff, 1905) and Bombina variegata scabra (Küster, 1843) in the district (“nomos”) of Ioannina, Northern Greece. Bombina variegata was found to be the most common species, followed by T. alpestris and T. carnifex while T. vulgaris seemed to be rare. The four taxa differed in habitat use and geographic distribution. Records of T. alpestris were limited to the highest sites in the north and east of the district. This species inhabited alpine lakes, but also smaller habitats such as drinking troughs and ponds. Four populations contained paedomorphic individuals. Triturus vulgaris appeared to be restricted to low altitude sites in the centre of the district where it lived in reservoirs, watering basins and drinking troughs. Triturus carnifex and B. variegata had a wider distribution and occupied a broader spectrum of habitats. Bombina variegata was the only species studied which lived in running waters (small brooks). Neither newts nor yellow-bellied toads were found in large rivers and lakes. In the district of Ioannina both habitat variety and distribution range of newts and Yellow-bellied Toads turned out to be greater than previously known. Alpine lakes containing very large populations of paedomorphic individuals should be protected given the rarity of the phenomenon. [less ▲]

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See detailVaricella-Zoster virus proteins encoded by open reading frames 14 and 67 are both dispensable for the establishment of latency in a rat model.
Grinfeld, Esther; Sadzot-Delvaux, Catherine ULiege; Kennedy, Peter G E

in Virology (2004), 323(1), 85-90

A rat model of Varicella-Zoster virus (VZV) provides a system in which to investigate the molecular determinants of viral latency in dorsal root ganglia (DRG). In this study, we determined whether the VZV ... [more ▼]

A rat model of Varicella-Zoster virus (VZV) provides a system in which to investigate the molecular determinants of viral latency in dorsal root ganglia (DRG). In this study, we determined whether the VZV glycoproteins gC and gI, corresponding to VZV open reading frames (ORFs) 14 and 67, respectively, were required for the establishment of latency in this model. A VZV gI deletion mutant (DeltagI) derived from a recombinant Oka (rOka) cosmid and a gC null mutant obtained from a clinical isolate were inoculated into the footpads of 6-week-old rats, and the presence of viral DNA and eight different VZV RNA transcripts corresponding to the three classes of genes was investigated by in situ RT-PCR amplification and in situ hybridization (ISH) in the DRG at 1 week, 1 month, and 18-24 months after infection. VZV DNA and restricted RNA expression was established with both deletion mutants as well as the parental rOka virus. Both VZV DNA and RNA were detected in neurons and non-neuronal cells. The pattern of viral RNA expression detected with both gC and gI mutants was restricted with transcripts for VZV genes 62 and 63 most frequently expressed 18-24 months after infection. Transcripts for VZV genes 18, 28, and 29 were also detected at these time points but at a slightly lower frequency. Transcripts for the late gene 40 were never detected. We conclude that VZV ORFs 14 and 67 are dispensable for the establishment of a latent infection in this model. [less ▲]

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See detailAdult Moyamoya disease.
Kouokam, L.; NCHIMI LONGANG, Alain ULiege; Tshibanda, J. F. et al

in JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) (2004), 87(3), 144-5

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See detailDiscrimination between Bifidobacterium species from human and animal origin by PCR-restriction fragment length polymorphism
Delcenserie, Véronique ULiege; Bechoux, Nathalie ULiege; Leonard, Tamara et al

in Journal of Food Protection (2004), 67(6), 1284-1288

Bifidobacteria are normal intestinal flora in humans and animals. The genus Bifidobacterium includes 31 species of significant host specificity. Taking into account their properties, we proposed to use ... [more ▼]

Bifidobacteria are normal intestinal flora in humans and animals. The genus Bifidobacterium includes 31 species of significant host specificity. Taking into account their properties, we proposed to use bifidobacteria as fecal contamination indicators. PCR-restriction fragment length polymorphism on the 16S rDNA gene was used to distinguish the different Bifidobacterium species. Sixty-four strains belonging to 13 different species were differentiated from animal or human origin using one or two restriction enzymes. Moreover, the primers used were specifics of the Bifidobacterium genus. Therefore, this method made it possible to determine both the presence of bifidobacteria in a sample and its origin of contamination. [less ▲]

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See detailFuite dans l'imaginaire et dépendance: trait de personnalité ou défense opportuniste chez le transsexuel
Michel, Aude; Mormont, Christian ULiege

in Encéphale (L') (2004), 30(2), 147-152

While analysing the psychological functioning of sex reassignment candidates, it appeared that they frequently use the mechanism which consist in taking refuge in passivity and fantasies so that they can ... [more ▼]

While analysing the psychological functioning of sex reassignment candidates, it appeared that they frequently use the mechanism which consist in taking refuge in passivity and fantasies so that they can avoid displeasing situations, responsibilities and decisions making. This unconscious process, identified by Exner in the Rorschach as the Snow-White Syndrome seems to take place in a specific way regarding the real situation faced by the sex reassignment candidates: the achievement of their aim (the sex reassignment) actually depends on the medical crew (doctors, psychologists, surgeons). We wondered if this fact consisted in a stylistic component, that is to say a stable feature of transsexuals' personality or in an opportunist defence. The dependence on the third, executor and decision-maker could be seen either as the indication of this feature being a favourable condition to the construction of the transsexual Issue or a consequence the transsexual's real situation. The hypothesis of the situational use of this process is studied by comparing the frequency of the Snow-White Syndrome during the moment before giving the surgical response with its appearance frequency after the sex reassignment. The individuals' retest (7MF/7FM) after the operation brings favourable arguments to the second interpretation since the process stops being used as soon as the passive dependence position doesn't exist anymore (the Snow-White Syndrome disappears in 70% of cases). So, as the goals are reached (the medico-surgical transformation materialising the desire), the flight in fantasies and passivity is not necessary anymore and the dependence on contributors disappears. During the psychological follow-up, attention should be paid to this psychic impact of anatomical reality so that it favours an earliest access to autonomy the transsexual is able to prove. In regard of a psychological view (in opposition with a surgical view), this autonomy could be researched before the body transformation, validating the "Real Life Test" experience. [less ▲]

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See detailDiscriminative stimulus effects of ethanol: Lack of interaction with taurine
Quertemont, Etienne ULiege; Grant, Kathleen A.

in Behavioural Pharmacology (2004), 15(7), 495-501

Recent microdialysis studies showed that ethanol administration increases the release of taurine in various rat brain regions, and it was suggested that this increase in extracellular concentrations of ... [more ▼]

Recent microdialysis studies showed that ethanol administration increases the release of taurine in various rat brain regions, and it was suggested that this increase in extracellular concentrations of taurine might mediate some of the neurochemical effects of ethanol. Previous drug discrimination studies showed that positive modulators of the GABA(A) receptor consistently substituted for ethanol discriminative stimulus effects. Since taurine is also believed to modulate GABA(A) receptor activity, this study addressed the hypothesis that taurine mediates the discriminative stimulus effects of ethanol due to GABA(A) activation. Male Long-Evans rats were trained to discriminate water from either 1 or 2 g/kg ethanol. In a first experiment, various taurine doses (0-500 mg/kg) were tested to investigate whether taurine substitutes for ethanol. In a second experiment, rats were pretreated with either 500 mg/kg taurine or an equivalent volume of saline before testing for ethanol discrimination with various ethanol doses (0-2.0 g/kg). The results showed that taurine does not substitute for ethanol at any tested doses. In addition, taurine pretreatments failed to modify the dose-response curve for ethanol discrimination. These results demonstrate that taurine is not directly involved in mediating the discriminative stimulus effects of ethanol. It is therefore very unlikely that the brain release of taurine observed after ethanol administration is implicated in the major pharmacological effects of ethanol, i.e. positive modulation of GABA(A) receptor, that mediate its discriminative stimulus effects. [less ▲]

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See detailImpact of hydroelectric power releases on the morphology and the sedimentology of the bed of the Warche River (Belgium).
Assani, A. A.; Petit, François ULiege

in Earth Surface Processes & Landforms (2004)

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See detailPathbase: A new reference resource and database for laboratory mouse pathology
Schofield, P. N.; Bard, J. B. L.; Boniver, Jacques ULiege et al

in Radiation Protection Dosimetry (2004), 112(4 Sp. Iss. SI), 525-528

Pathbase (http://www.pathbase.net) is a web accessible database of histopathological images of laboratory mice, developed as a resource for the coding and archiving of data derived from the analysis of ... [more ▼]

Pathbase (http://www.pathbase.net) is a web accessible database of histopathological images of laboratory mice, developed as a resource for the coding and archiving of data derived from the analysis of mutant or genetically engineered mice and their background strains. The metadata for the images, which allows retrieval and interoperability with other databases, is derived from a series of orthogonal ontologies and controlled vocabularies. One of these controlled vocabularies, MPATH, was developed by the Pathbase Consortium as a formal description of the content of mouse histopathological images. The database currently has over 1000 images on-line with 2000 more under curation and presents a paradigm for the development of future databases dedicated to aspects of experimental biology. [less ▲]

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See detailInvasion and MMP expression profile in desmoid tumours.
Denys, H.; De Wever, O.; Nusgens, Betty ULiege et al

in British Journal of Cancer (2004), 90(7), 1443-9

Desmoid tumours are locally invasive soft tissue tumours in which beta-catenin mediated TCF-dependent transcription is activated. The role of soluble factors secreted by the myofibroblastic desmoid tumour ... [more ▼]

Desmoid tumours are locally invasive soft tissue tumours in which beta-catenin mediated TCF-dependent transcription is activated. The role of soluble factors secreted by the myofibroblastic desmoid tumour, which could stimulate tumour invasiveness, was investigated. Using collagen gel invasion assays, the presence of factors stimulating invasion in desmoid conditioned media (CM) could be established. Since matrix metalloproteinases (MMPs) have been implicated in the process of tumoral invasion, the expression levels of the MMP family members were evaluated. Quantitative reverse transcription-PCR was used to determine the expression levels of MMP1, MMP2, MMP3, MMP7, MMP11, MMP12, MMP13, MMP14 and the inhibitors TIMP1, TIMP2 and TIMP3. Besides overexpression of MMP7, a known TCF-dependent target gene, a striking upregulation of the expression levels of MMP1, MMP3, MMP11, MMP12 and MMP13 in desmoid tumours, compared to unaffected fibroblasts from the same patients, was found. Treating the CM of desmoids with a synthetic and a physiologic MMP inhibitor reduced the invasion-stimulating capacity of the desmoid CM by approximately 50%. These results suggest the involvement of soluble factors, released by the desmoid cells, in stimulating invasion and implicate the MMPs as facilitators of invasion. [less ▲]

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See detailDownregulation of ICAM-1 and VCAM-1 expression in endothelial cells treated by photodynamic therapy
Volanti, Cédric ULiege; Gloire, Geoffrey ULiege; Vanderplasschen, Alain ULiege et al

in Oncogene (2004), 23(53), 8649-8658

Photodynamic therapy (PDT) is a treatment for cancer and several noncancerous proliferating cell diseases that depends on the uptake of a photosensitizing compound followed by selective irradiation with ... [more ▼]

Photodynamic therapy (PDT) is a treatment for cancer and several noncancerous proliferating cell diseases that depends on the uptake of a photosensitizing compound followed by selective irradiation with visible light. In the presence of oxygen, irradiation leads to the production of reactive oxygen species (ROS). A large production of ROS induces the death of cancer cells by apoptosis or necrosis. A small ROS production can activate various cellular pathways. Here, we show that PDT by pyropheophorbide-a methyl ester (PPME) induces the activation of nuclear factor kappa B (NF-kappaB) in HMEC-1 cells. NF-kappaB is active since it binds to the NF-kappaB sites of both ICAM-1 and vascular cell adhesion molecule-1 (VCAM-1) promoters and induces the transcription of several NF-kappaB target genes such as those of IL-6, ICAM-1, VCAM-1. In contrast, expression of ICAM-1 and VCAM-1 at the protein level was not observed, although we measured an IL-6 secretion. Using specific chemical inhibitors, we showed that the lack of ICAM-1 and VCAM-1 expression is the consequence of their degradation by lysosomal proteases. The proteasome and calpain pathways were not involved. All these observations were consistent with the fact that no adhesion of granulocytes was observed in these conditions. [less ▲]

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See detailL'adhésion amélo-dentinaire: Principes et état actuels des connaissances.
Gueders, Audrey ULiege; Geerts, Sabine ULiege

in Actualités Dentaires de l'université de Liège (2004), 34

La stratégie d'adhésion varie en fonction du type d'adhésif utilisé. Cet article décrit les différents systèmes adhésifs disponibles

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See detailMuscular imbalance and acute lower extremity muscle injuries in sport
Croisier, Jean-Louis ULiege

in International SportMed Journal (2004), 5(3), 169-176

Investigating factors associated with muscle strains highlight the multifactorial origin of the injury and the difficulty of identifying isolated or combined factors that caused the injury. Among the ... [more ▼]

Investigating factors associated with muscle strains highlight the multifactorial origin of the injury and the difficulty of identifying isolated or combined factors that caused the injury. Among the numerous causes reported in the literature, only a few have been scientifically associated with injury occurrence, while others have been empirically suggested. Contradictions in articles dealing with muscle strength and imbalance are frequent, and are probably the result of differences in methodology and criteria for patient inclusion. Imbalance in muscle strength commonly refers to abnormal bilateral asymmetry (between homologous groups) and a disruption of the agonist-antagonist ratio. Some authors who focus on a history of hamstring or adductor strains have demonstrated the frequent abnormality of muscle strength and balance by means of isokinetic assessment. Mixed ratios, combining the eccentric performance of “decelerating” muscles (such as the hamstrings) and the concentric performance of “mobiliser” muscles (such as the quadriceps) are suggested and seem relevant. An increased emphasis on eccentric strengthening exercises, particularly for the hamstrings, and ratio correction on the basis of statistically selected cut-offs, significantly reduces the recurrence rate of the injury and lingering complaints upon return-to-sport. Similarly, isokinetic interventions, as a preseason screening tool in sports where there is a high rate of muscle strain injuries, could detect imbalances early and thus promote a preventive strategy. [less ▲]

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See detailA Parasite Reveals Cryptic Phylogeographic History of Its Host: The Colonization of the Western Mediterranean Islands
Nieberding, Caroline; Morand, Serge; Libois, R. et al

in Multidisciplinarity for Parasites, Vectors and Parasitic Diseases (2004), 1

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See detailLa bronchopneumopathie éosinophilique idiopathique canine : revue de la littérature
Peeters, Dominique ULiege; Clercx, Cécile ULiege

in Annales de Médecine Vétérinaire (2004), 148(3), 115-120

Several diseases characterized by pulmonary eosinophilic infiltrates are described in the dog, but a clear and accepted classification of these disorders is lacking. In the present paper, we briefly ... [more ▼]

Several diseases characterized by pulmonary eosinophilic infiltrates are described in the dog, but a clear and accepted classification of these disorders is lacking. In the present paper, we briefly review most of these conditions through a classification based on the cause of the eosinophilic infiltrate. A complete literature review of canine idiopathic eosinophilic bronchopneumopathy is also included in the paper. [less ▲]

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See detailEctopic ureters in the dog: literature review and case reports in 3 male dogs
Pollaci, Elsa; Balligand, Marc; Hamaide, Annick ULiege

in Annales de Médecine Vétérinaire (2004), 148(2), 103-109

Ureteral ectopia is a congenital abnormality in which one or both ureters does not open into the bladder. This is the most common cause of urinary incontinence in the immature bitch, but is rarely ... [more ▼]

Ureteral ectopia is a congenital abnormality in which one or both ureters does not open into the bladder. This is the most common cause of urinary incontinence in the immature bitch, but is rarely diagnosed in the male dog. Some breeds are predisposed (Siberian Husky, Labrador, Golden Retriever). Typical clinical signs are a continuous (but sometimes intermittent) leakage of urine since birth, although micturition can be normal. Other associated congenital abnormalities can be present (hydronephrosis, double vagina, cryptorchidism). Diagnostic techniques include excretory urography coupled with a pneumocystography, vaginourethrography, cystoscopy, vaginoscopy, and ultrasonography. Ectopic ureters can be unilateral (most commonly) or bilateral, and they are either intramural or extramural. Surgical correction is the treatment of choice. After a successful surgery, some patients can still show some degree of incontinence, due to the presence of urethral sphincter mechanism incompetence. This residual incontinence can be resolved in the majority of the cases with the use of alpha-adrenergic agents. [less ▲]

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See detailHigh incidence of complications after 2-chloro-2'-deoxyadenosine combined with cyclophosphamide in patients with advanced lymphoproliferative malignancies.
Van Den Neste, E.; Michaux, L.; LAYIOS, Nathalie ULiege et al

in Annals of Hematology (2004), 83(6), 356-63

The combination of purine analogs with alkylating agents is able to produce a synergistic antitumoral effect. However, the addition of immunosuppressive and DNA-targeting agents might increase purine ... [more ▼]

The combination of purine analogs with alkylating agents is able to produce a synergistic antitumoral effect. However, the addition of immunosuppressive and DNA-targeting agents might increase purine analog-related complications. The risk for serious complications was evaluated in 38 patients treated with 2-chloro-2'-deoxyadenosine (CDA) and cyclophosphamide (CP). The diagnoses were chronic lymphocytic leukemia (CLL) in 15, Waldenstrom's macroglobulinemia in 4, mantle cell lymphoma in 6, follicular non-Hodgkin's lymphoma (NHL) in 10, and other low-grade NHL in 3 patients. All patients were pretreated (median: 2 lines, range: 1-5) and 23 (61%) were refractory. The patients received a median of two courses (range: 1-5) of 5.6 mg/m(2) CDA, followed by a median of 200 mg/m(2) CP, for 3 days. The response rate was 51% [complete remission (CR): 14%, partial remission (PR): 38%]. Grade 3/4 infections occurred in 16 (42%) patients. Dose-limiting cytopenias were seen in 22 (58%) patients. In 12 (32%) patients, autoimmune manifestations developed requiring treatment in most of them. Second cancers arose in five (13%) patients (myelodysplastic syndrome/acute myelocytic leukemia in three, lung cancer in two). Multivariate analysis showed that cytopenias, gender (F), prior radiotherapy, and age (>65 years) predicted for the complications seen after CDA-CP. To conclude, because of the high incidence of complications, caution is warranted in selecting patients with advanced lymphoid malignancies for the CDA-CP protocol. [less ▲]

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See detailEffect of reducing energy supply during the finishing of Belgian Blue double-muscled cull cows
Cabaraux, Jean-François ULiege; Dotreppe, Olivier ULiege; Dufrasne, Isabelle ULiege et al

in Animal Science (2004), 79(Part 3), 469-482

A 4-year experiment has been conducted on finishing Belgian Blue cull cows of double-muscled type in order to study the effects of diets containing adequate levels of metabolizable protein, but either ... [more ▼]

A 4-year experiment has been conducted on finishing Belgian Blue cull cows of double-muscled type in order to study the effects of diets containing adequate levels of metabolizable protein, but either normal (NENP), low (LENP) or medium (MENP) levels of metabolizable energy, on animal performance, carcass and meat characteristics, and plasma metabolites and hormones. The LENP diet was offered during the whole (LENP group) or second half of the finishing (NENP-LENP groups), and the MENP diet during the whole finishing (MENP group). The degree of fatness required for the slaughter of animals from NENP groups was close to 4.5 (scale from 0 (very lean) to 5 (very fat)). In each underfed group, the slaughter of the animals was synchronized to that of NENP cows, by degressive degree of fatness. The same duration of finishing was thus obtained for all groups. The experimental feeding strategies reduced the amounts of fat deposited in the carcass and the meat while muscle deposition was remarkably preserved. The proportions of saturated and monounsaturated fatty acids in intramuscular fat were also decreased while their proportions increased in plasma free fatty acids. Plasma insulin levels were also reduced and those of IGF-1 were, surprisingly, maintained. The low energy diet promoted thus the settlement of a discrete lipolytic state while high levels of IGF-1 preserved muscle deposition. This feeding strategy should be evaluated in other breeds of cattle. [less ▲]

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See detailWork Integration Social Enterprises in the European Union: an Overview of Existing Models
Davister, Catherine; Defourny, Jacques ULiege; Grégoire, Olivier

in RECMA – Revue Internationale de l'Economie Sociale (2004), 293

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See detailEffects of age on plasma metabolites and hormones in finishing Belgian Blue double-muscled cull females
Cabaraux, Jean-François ULiege; Dufrasne, Isabelle ULiege; Istasse, Louis ULiege et al

in Animal Science (2004), 78(Part 2), 229-235

Two groups of 12 Belgian Blue double-muscled cull females were used successively in a 2-year repeated experiment and divided into three groups according to age, allowing four animals per group each year ... [more ▼]

Two groups of 12 Belgian Blue double-muscled cull females were used successively in a 2-year repeated experiment and divided into three groups according to age, allowing four animals per group each year. The aim of the trial was to relate, during the finishing period, the metabolic and endocrine parameters with age. Females were fattened with a diet based on maize silage and were blood sampled on several occasions. The average daily gain (ADG) decreased with the age of the cows. Plasma glucose and triglycerides decreased also with age while the youngest females showed lower concentrations of urea than those older. The composition of plasma non-esterified fatty acids also differed considerably between groups. The hormones that best related with ADG were IGF-1 and insulin. Plasma concentrations of thyroid hormones were lower in the oldest animals. No difference between groups was found for GH. Heifers presented lower concentrations of GH and IGF-1 than those reported elsewhere in fattening bulls of the same breed. It may be concluded that in Belgian Blue double-muscled females, glucose, IGF-1 and insulin are good indicators of the growth potential. Young adult cows presented intermediate characteristics of metabolic and endocrine status that were close either to younger or to older cows. [less ▲]

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See detail“Peculiar Sites of Amnesia: Recovering the ‘Eclipsed Figures of the Past’ in Francis Quamina Farrier’s The Slave and the Scroll and Michael Gilkes’s Couvade.”
Bada, Valérie ULiege

in Bridges Across Chasms. Towards a Transcultural Future in Caribbean Literature. Ed. Bénédicte Ledent. (2004)

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See detailEffects of the calving number on animal performance, carcass and meat composition in finishing Belgian Blue double-muscled culled females
Cabaraux, Jean-François ULiege; Hornick, Jean-Luc ULiege; Dotreppe, Olivier ULiege et al

in Livestock Production Science (2004), 87(2-3), 161-169

In a 2-year experiment, 66 Belgian Blue (BB) double-muscled culled females have been divided in three groups according to the calving number (heifers-H, cows culled after two calvings-C2 or four calvings ... [more ▼]

In a 2-year experiment, 66 Belgian Blue (BB) double-muscled culled females have been divided in three groups according to the calving number (heifers-H, cows culled after two calvings-C2 or four calvings-C4) and finished on a maize silage-based diet in order to compare animal performance and evolution of carcass and meat characteristics with age. Four females per group were slaughtered on day 0 to assess carcass and meat characteristics of lean animals. The initial and final live weights, the carcass weight and the daily food intake increased with advancing age, while the live weight gain and feed efficiency decreased. The H presented the higher killing-out and muscle proportions and the lower adipose tissue proportion. Their meat was less dark and less red than that of older cows. The lowest protein content and the highest fat content in meat dry matter were found in the C2. In the three groups, the carcass and meat became fatter with finishing process. The amplitude of fat deposition was the highest in C2. It can be concluded that the performance of BB culled females vary with age. The carcass and meat characteristics differ mainly between H and cows, few differences appearing between cows. (C) 2003 Elsevier B.V All rights reserved. [less ▲]

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See detailImmune response and antigen recognition in non-pregnant ewes experimentally infected with Neospora caninum tachyzoites.
Rettigner, Chantal; Lasri, Saadia; De Meerschman, Francois et al

in Veterinary Parasitology (2004), 122(4), 261-71

The cellular and humoral responses as well as the antigen recognition during the acute stage of a Neospora caninum (NC) infection were investigated in non-pregnant ewes. The experimentally infected ewes ... [more ▼]

The cellular and humoral responses as well as the antigen recognition during the acute stage of a Neospora caninum (NC) infection were investigated in non-pregnant ewes. The experimentally infected ewes developed specific lymphoproliferative and humoral responses within 2 weeks post-infection (PI). The magnitude of the cellular response showed large variations between animals. A significant decrease in the proliferative response to Con A mitogen and N. caninum, Toxoplasma gondii (TG) antigens was recorded on day 21 post-infection (PI). The humoral response and the pattern of antigen recognition were similar among infected ewes. Proteins of 44, 42, 40, 39 and 28 kDa were intensively recognized by the infected animals during the experiment. The 42 and 28 kDa antigens should be considered as useful for the diagnostic of N. caninum infection, as the intensity of recognition infection of the other antigens had decreased markedly 8 weeks post-infection. For some antigens a sequential recognition was recorded. The 59, 54 and 38-37 kDa proteins were frequently recognized by infected sera during the first weeks of the infection, but recognition of these antigens was absent or rare at the end of the experiment. These antigens could be related to the acute stage of the infection. [less ▲]

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See detailFetal growth restriction: a workshop report
Cetin, I.; Foidart, Jean-Michel ULiege; Miozzo, M. et al

in Placenta (2004), 25(8-9), 753-757

Intrauterine growth restriction (IUGR) is associated with significantly increased perinatal morbidity and mortality as well as cardiovascular disease and glucose intolerance in adult life. A number of ... [more ▼]

Intrauterine growth restriction (IUGR) is associated with significantly increased perinatal morbidity and mortality as well as cardiovascular disease and glucose intolerance in adult life. A number of disorders from genetic to metabolic, vascular, coagulative, autoimmune, as well as infectious, can influence fetal growth by damaging the placenta, leading to IUGR as a result of many possible fetal, placental and maternal disorders. Strict definitions of IUGR and of its severity are needed in order to eventually distinguish among different phenotypes, such as gestational age at onset, degree of growth restriction and presence of hypoxia. This report explores and reviews some of the most recent developments in both clinical and basic research on intrauterine growth restriction, by seeking mechanisms that involve genetic factors, utero-placental nutrient availability and vascular growth factors. New exciting findings on the genomic imprinting defects potentially associated with IUGR, and the placental anomalies associated with the decreased nutrient transport are summarized. Moreover, recent data on angiogenic growth factors as well as new information arising from application of gene chip technologies are discussed. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailA nation-wide project for the revision of the Belgian nursing minimum dataset: from concept to implementation.
SERMEUS, Walter; VAN DEN HEEDE, Koen; MICHIELS, Dominik et al

in Studies in Health Technology & Informatics (2004), 110

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See detailChèvremont, Chyvecourt et Chaudfontaine: histoire d'une configuration toponymique
Boutier, Marie-Guy ULiege

in Bulletin de la Commission Royale de Toponymie et de Dialectologie = Handelingen van de Koninklijke Commissie voor Toponymie en Dialectologie (2004), 76

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See detailLes nouveaux médicaments de l'arthrose
Reginster, Jean-Yves ULiege; Henrotin, Yves ULiege

in Pharma-Sphère (2004), 85

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See detailImpact of training and exercise intensity on blood antioxidant markers in healthy Standardbred horses
De Moffarts, Brieuc; Kirschvink, Nathalie; Art, Tatiana ULiege et al

in Equine & Comparative Exercise Physiology (2004), 1(3), 211-220

This study investigated the effect of training and exercise intensity on blood antioxidant markers in six healthy Standardbred horses. Markers studied were uric acid (UA), ascorbic acid (AA), α-tocopherol ... [more ▼]

This study investigated the effect of training and exercise intensity on blood antioxidant markers in six healthy Standardbred horses. Markers studied were uric acid (UA), ascorbic acid (AA), α-tocopherol, vitamin A (Vit A), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione – reduced (GSH) and oxidized (GSSG), glutathione redox ratio (GRR), copper (Cu), zinc (Zn) and selenium (Se). The horses performed a standardized exercise test (SET) when they were untrained (T0), after 4 weeks of light training (T4) and after 8 weeks of interval training (T12). Forty-eight hours after SET T4 and SET T12, a SET with run up to fatigue (TTF4 and TTF12) was performed. Maximal oxygen consumption (V˙O2max) was determined within 3–5 days after TTF4 and TTF12. At each test (SET T(i) and TTF(i)), venous blood was sampled at rest (R), peak-exercise (Emax), 15 (E15) and 60 (E60) min after the test. UA, AA and GRR were increased significantly by the exercise, whereas GSH and Vit A were decreased significantly (P<0.05). Training-related increases (T0 vs. T4 vs. T12) were observed for UA, SOD, GPx and Se, whereas GSH, α-tocopherol and Zn decreased (P<0.05). Exercise intensity (TTF(i) vs. T(i)) increased UA and AA significantly and decreased GSH significantly (P<0.05). A significant correlation between ΔSOD and ΔV˙O2max (r=0.86, p<0.05) determined at SET T4 and SET T12 was found. Taken together, these results indicate that training and exercise intensity significantly influence blood antioxidant markers in healthy Standardbred horses [less ▲]

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See detailTra Madrid e Guernica. Guerra civile spagnola e città ferite nella narrativa italiana (1996-2002)
Curreri, Luciano ULiege

in Cahiers d'études italiennes (2004), 1

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See detailEnhancement of lysozyme stability and activity by polyamines
Powroznik, Brigitte; Gharbi, Myriam ULiege; Dandrifosse, Guy ULiege et al

in Biochimie (2004), 86(9-10, Sep-Oct), 651-656

Spermine, a low molecular weight polyamine, administered orally to suckling rats induces the maturation of the small intestine. In this organ, lysozyme is an important component of the innate immunity. In ... [more ▼]

Spermine, a low molecular weight polyamine, administered orally to suckling rats induces the maturation of the small intestine. In this organ, lysozyme is an important component of the innate immunity. In this report, we analysed the binding of spermine to lysozyme and its effect on thermal inactivation of the protein by spectroscopy techniques. The activity of the enzyme was analysed in presence of spermine by lysoplate technique. We studied the effects of spermine ingestion by suckling rats on intestinal lysozyme activity and gene expression. We reported that spermine binds to lysozyme and increases in vitro the thermal stability and the activity of the protein. When administered orally to suckling rats, spermine increases the lysozyme activity in jejunum, but not in ileum. This increase is not due to a modification of the gene expression. The observed effects lead us to postulate that spermine could be used in some mammals as a promoter of the innate immunity. (C) 2004 Elsevier SAS. All rights reserved. [less ▲]

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See detailL'image du mois. Un courant d'air.
ROUSSEAU, Anne-Françoise ULiege; CANIVET, Jean-Luc ULiege; CAMPOLINI, Christophe

in Revue Médicale de Liège (2004), 59(10), 550-551

Portal venous gas is a rare radiological symptom related to several possible causes. Its severity is only correlated with the severity of the primary disease. We report the case of a portal pneumatose ... [more ▼]

Portal venous gas is a rare radiological symptom related to several possible causes. Its severity is only correlated with the severity of the primary disease. We report the case of a portal pneumatose. The diagnosis was made by ultrasound and CT scan. [less ▲]

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See detailExpression of 25 kDa thiamine triphosphatase in rodent tissues using quantitative PCR and characterization of its mRNA
Lakaye, Bernard ULiege; Verlaet, Myriam ULiege; Dubail, Johanne ULiege et al

in International Journal of Biochemistry & Cell Biology (2004), 36(10), 2032-2041

Thiamine triphosphate (ThTP) is found in most organisms, but its biological role remains unclear. In mammalian tissues, cellular ThTP concentrations remain low, probably because of hydrolysis by a ... [more ▼]

Thiamine triphosphate (ThTP) is found in most organisms, but its biological role remains unclear. In mammalian tissues, cellular ThTP concentrations remain low, probably because of hydrolysis by a specific 25 kDa thiamine triphosphatase (ThTPase). The aim of the present study was to use quantitative PCR, for comparing the 25 kDa ThTPase mRNA expression in various mouse tissues with its enzyme activities. ThTPase mRNA was expressed at only a few copies per cell. The highest amount of mRNA was found in testis, followed by lung and muscle, while the highest enzyme activities were found in liver and kidney. The poor correlation between mRNA levels and enzyme activities might result either from tissue-specific post-transcriptional regulation of mRNA processing and/or translation or from the regulation of enzyme activities by post-translational mechanisms. Purified recombinant human ThTPase was phosphorylated by casein kinase 11, but this phosphorylation did not modify the enzyme activity. However, the characterization of the 3'-untranslated mRNA region revealed a unique, highly conserved, 200-nucleotide sequence that might be involved in translational control. In situ hybridization studies in testis suggest a predominant localization of ThTPase mRNA in poorly differentiated spermatogenic cells. This is the first study demonstrating a cell-specific 25 kDa ThTPase mRNA expression, suggesting that this enzyme might be related to the degree of differentiation or the metabolic state of the cell. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailThe genus Biernatella Baliński, 1977 (Brachiopoda) from the late Frasnian of Belgium
Mottequin, Bernard ULiege

in Bulletin de l'Institut Royal des Sciences Naturelles de Belgique. Sciences de la Terre (2004), 74 (supplément)

The genus Biernatella (Brachiopoda; Athyridida), characterized by the presence of a diplospiralium, is definitely recognized for the first time in the late Frasnian (Lower-Upper Palmatolepis rhenana Zones ... [more ▼]

The genus Biernatella (Brachiopoda; Athyridida), characterized by the presence of a diplospiralium, is definitely recognized for the first time in the late Frasnian (Lower-Upper Palmatolepis rhenana Zones) of the southern flank of the Dinant Synclinorium and of the Philippeville Anticlinorium (southern Belgium). A new species (B. abunda n. sp.) from the Neuville Formation (Dinant Synclinorium) is described. In the Philippeville Anticlinorium, B. abunda n. sp. occurs in the Neuville Formation and probably at the base of the Les Valisettes Formation but specifically unidentified specimens of Biernatella have also been collected near the top of this last formation. [less ▲]

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See detailLes prophètes de la cathédrale de Strasbourg
Van den Bossche, Benoît ULiege

in Bulletin de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique. Beaux-Arts (2004), 1-6

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See detailExpression of Galectins in Cancer: A Critical Review
van den Brule, Frédéric; Califice, Stéphane; Castronovo, Vincenzo ULiege

in Glycoconjugate Journal (2004), 19(7-9), 537-42

A large body of literature has examined and described galectin expression in cancer. Discrepancies have been observed in the reported data, which hampered clear understanding of the expression profiles ... [more ▼]

A large body of literature has examined and described galectin expression in cancer. Discrepancies have been observed in the reported data, which hampered clear understanding of the expression profiles. This relates to the use of different types of methods that evaluate either global or specific gene expression in heterogeneous cancer tissue samples, type of antibodies used in immunohistochemistry and procedures of comparison of gene expression. In this manuscript, we review the main data concerning expression of galectins in human cancer. Only galectin-1 and galectin-3, the most abundant and examined galectins, will be examined here. [less ▲]

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See detailTraitement du cancer du sein chez la personne âgée
Gillain, Sophie ULiege; Gennigens, Christine ULiege; Sautois, Brieuc ULiege et al

in Revue Médicale Suisse (2004), 62

Le cancer du sein représente chez la personne âgée une pathologie fréquente. Le choix du traitement dépend de l'âge physiologique, des pathologies et comorbidités associées ainsi que du niveau de vie et d ... [more ▼]

Le cancer du sein représente chez la personne âgée une pathologie fréquente. Le choix du traitement dépend de l'âge physiologique, des pathologies et comorbidités associées ainsi que du niveau de vie et d'autonomie. De plus, selon les facteurs histopronostiques (récepteurs aux oestrogènes et à la progestérone, la surexpression du cerb-B2) on décidera éventuellement du schéma thérapeutique le plus approprié. Chez la personne âgée, la chirurgie (mastectomie ou tumorectomie), la radiothérapie et l'hormonothérapie trouvent leur place. Au-delà de 70 ans, la place de la chimiothérapie est incertaine. En effet, les patientes de plus de 70 ans sont sous-représentées dans les études randomisées. [less ▲]

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See detailMineral mapping in salt lakes from Sud Lipez (Bolivia) using Aster images
Caceres, Fernando; Ali-Ammar, Hamid; Pirard, Eric ULiege

in Geological Remote Sensing Group Newsletter (2004), (38), 15-19

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See detailControl of vesicle fusion by a tyrosine phosphatase.
Huynh, Huong; Bottini, Nunzio; Williams, Scott et al

in Nature cell biology (2004), 6(9), 831-9

The tyrosine phosphatase PTP-MEG2 is targeted by its amino-terminal Sec14p homology domain to the membrane of secretory vesicles. There it regulates vesicle size by promoting homotypic vesicle fusion by a ... [more ▼]

The tyrosine phosphatase PTP-MEG2 is targeted by its amino-terminal Sec14p homology domain to the membrane of secretory vesicles. There it regulates vesicle size by promoting homotypic vesicle fusion by a mechanism that requires its catalytic activity. Here, we identify N-ethylmaleimide-sensitive factor (NSF), a key regulator of vesicle fusion, as a substrate for PTP-MEG2. PTP-MEG2 reduced the phosphotyrosine content of NSF and co-localized with NSF and syntaxin 6 in intact cells. Furthermore, endogenous PTP-MEG2 co-immunoprecipitated with endogenous NSF. Phosphorylation of NSF at Tyr 83, as well as an acidic substitution at the same site, increased its ATPase activity and prevented alphaSNAP binding. Conversely, expression of a Y83F mutant of NSF caused spontaneous fusion events. Our results suggest that the molecular mechanism by which PTP-MEG2 promotes secretory vesicle fusion involves the local release of NSF from a tyrosine-phosphorylated, inactive state. This represents a novel mechanism for localized regulation of NSF and the first demonstrated role for a protein tyrosine phosphatase in the regulated secretory pathway. [less ▲]

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See detailFrom palaeosols to carbonate mounds: facies and environments of the middle Frasnian platform in Belgium
Da Silva, Anne-Christine ULiege; Boulvain, Frédéric ULiege

in Geological Quarterly (2004), 48(3), 253-265

This paper provides a synthetic sedimentological overview of the middle Frasnian carbonate platform of Belgium and associated carbonate mounds. Carbonate mounds started usually in a relatively deep, quiet ... [more ▼]

This paper provides a synthetic sedimentological overview of the middle Frasnian carbonate platform of Belgium and associated carbonate mounds. Carbonate mounds started usually in a relatively deep, quiet subphotic environment with a crinoid-coral-sponge assemblage, then reached the fair-weather wave base and the euphotic zone with an algal-microbial facies. The upper parts of the mounds are characterised by lateral facies differentiation with the algal-microbial facies protecting a central sedimentation area with a dendroid stromatoporoids facies and fenestral limestone. The lateral facies reflect different kinds of input of reworked mound material in the proximal area, from transported fine-grained sediment to coarse-grained fossil debris. On the platform, environments range from the outer zone (crinoidal facies) to stromatoporoid-dominated biostromes and to the lagoonal area of the inner zones (subtidal facies with Amphipora floatstone, algal packstone, intertidal mudstone and laminated peloidal packstone and palacosols). These facies are stacked in metre-scale shallowing-upward cycles. The larger scale sequential organisation corresponds to transgressions and regressions, whose cycles are responsible for differentiating a lower open-marine biostrome dominated unit from an upper lagoonal unit. The last regression-transgression cycle, responsible for the platform-scale development of lagoonal facies, can be correlated with an atoll-stage evolution of the carbonate mounds belonging to the Lion Member. [less ▲]

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See detailApplication de l'échographie à l'étude de la dynamique folliculaire à l'oestrus induit chez les femelles zébu "Goudali"
Pitala, W.; Boly, H.; Coulibaly, I. et al

in Tropicultura (2004), 22(3), 110-115

L’échographie transrectale a été utilisée pour suivre la dynamique folliculaire chez 8 femelles zébu ‘Goudali’. Les animaux ont été répartis comme suit: Groupe 1: utilisation d’implant Crestar combiné à ... [more ▼]

L’échographie transrectale a été utilisée pour suivre la dynamique folliculaire chez 8 femelles zébu ‘Goudali’. Les animaux ont été répartis comme suit: Groupe 1: utilisation d’implant Crestar combiné à PGF2 et PMSG (n= 4); Groupe 2: implant Crestar combiné à PMSG (n= 2) et Groupe 3: implant Crestar combiné à PGF2 (n= 2). L’échographie a été réalisée le jour de la pose des implants, au moment du retrait, et à intervalle de 4 heures entre la 28e et la 56e heure après retrait. La détermination du nombre de corps jaunes a été faite 7 jours après l’ovulation. Le jour du retrait, le nombre de follicules de diamètre compris entre 2-3 mm a été de respectivement 5,8 ± 2,2; 3,5 ± 0,7 et 4,5 ± 0,7 pour les Groupes 1, 2 et 3. Au début des chaleurs (30,4 ± 4,9 heures après le retrait des implants); 4,1 ± 1,3 follicules ayant un diamètre moyen de 5-6 mm ont été observées pour les trois groupes. Une moyenne de 1,1 ± 0,4 follicules dominants (> 8 mm) a été observée à partir de la 36e heure après la fin du traitement. Le diamètre des follicules pré-ovulatoires n’a pas différé entre les groupes. Les premières ovulations ont été observées entre 22 et 26 heures après le début des chaleurs. [less ▲]

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See detailFunctional neuroimaging in the vegetative state
Laureys, Steven ULiege

in NeuroRehabilitation (2004), 19(4), 335-341

The interest of functional imaging in patients in a vegetative state is twofold. First, the vegetative state continues to represent a major clinical and ethical problem, in terms of diagnosis, prognosis ... [more ▼]

The interest of functional imaging in patients in a vegetative state is twofold. First, the vegetative state continues to represent a major clinical and ethical problem, in terms of diagnosis, prognosis, treatment, everyday management and end-of-life decisions. Second, it offers a lesional approach to the study of human consciousness and adds to the international research effort on identifying the neural correlate of consciousness. Cerebral metabolism has been shown to be massively reduced in the vegetative state. However, recovery of consciousness from vegetative state seems not always associated with substantial changes in global metabolism. Recent PET data indicate that some vegetative patients are unconscious not just because of a global loss of neuronal function, but due to an altered activity in a critical fronto-parietal cortical network and to abolished functional connections within this network and with non-specific thalamic nuclei. Recovery of consciousness was shown to be paralleled by a restoration of this cortico-thalamo-cortical interaction. Despite the metabolic impairment, external stimulation still induces neuronal activation as shown by both auditory and noxious stimuli. However, this activation is limited to primary cortices and dissociated from higher-order associative cortices, thought to be necessary for conscious perception. [less ▲]

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See detailTEM evidence for eukaryotic diversity in mid-Proterozoic oceans
Javaux, Emmanuelle ULiege; Knoll, A. H.; Walter, Malcolm

in Geobiology (2004), 2

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See detailGenetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism
Quertemont, Etienne ULiege

in Molecular Psychiatry (2004), 9(6), 570-581

Acetaldehyde, the first product of ethanol metabolism, has been speculated to be involved in many pharmacological and behavioral effects of ethanol. In particular, acetaldehyde has been suggested to ... [more ▼]

Acetaldehyde, the first product of ethanol metabolism, has been speculated to be involved in many pharmacological and behavioral effects of ethanol. In particular, acetaldehyde has been suggested to contribute to alcohol abuse and alcoholism. In the present paper, we review current data on the role of acetaldehyde and ethanol metabolism in alcohol consumption and abuse. Ethanol metabolism involves several enzymes. Whereas alcohol dehydrogenase metabolizes the bulk of ethanol within the liver, other enzymes, such as cytochrome P4502E1 and catalase, also contributes to the production of acetaldehyde from ethanol oxidation. In turn, acetaldehyde is metabolized by the enzyme aldehyde dehydrogenase. In animal studies, acetaldehyde is mainly reinforcing particularly when injected directly into the brain. In humans, genetic polymorphisms of the enzymes alcohol dehydrogenase and aldehyde dehydrogenase are also associated with alcohol drinking habits and the incidence of alcohol abuse. From these human genetic studies, it has been concluded that blood acetaldehyde accumulation induces unpleasant effects that prevent further alcohol drinking. It is therefore speculated that acetaldehyde exerts opposite hedonic effects depending on the localization of its accumulation. In the periphery, acetaldehyde is primarily aversive, whereas brain acetaldehyde is mainly reinforcing. However, the peripheral effects of acetaldehyde might also be dependent upon its peak blood concentrations and its rate of accumulation, with a narrow range of blood acetaldehyde concentrations being reinforcing. [less ▲]

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See detailSodium bromide encephalopathy with decreased serum Cl- level and increased anion gap: report of one case.
Robe, Pierre ULiege; Sadzot, Bernard ULiege; Frank, Georges

in European Neurology (2004), 51(4), 246-7

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See detailTanguy, de la fiction à la réalité
Gavray, Claire ULiege

in Observatoire : Revue d'Action Sociale & Médico-Sociale (2004), 42

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See detailDecision tree algorithm for detection of spatial processes in landscape transformation.
Bogaert, Jan ULiege; Ceulemans, R; Salvador-Van Eysenrode, D

in Environmental Management (2004), 33(1), 62-73

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See detailAd libitum feeding following ovariectomy in female Beagle dogs: effect on maintenance energy requirement and on blood metabolites.
Jeusette, Isabelle; Detilleux, Johann ULiege; Cuvelier, Christine ULiege et al

in Journal of Animal Physiology & Animal Nutrition (2004), 88(3-4), 117-21

The aim of this study was (i) to evaluate the effect of ovariectomy on daily energy requirement in Beagle dogs, and (ii) to evaluate the effects of ad libitum feeding with a high energy diet on energy ... [more ▼]

The aim of this study was (i) to evaluate the effect of ovariectomy on daily energy requirement in Beagle dogs, and (ii) to evaluate the effects of ad libitum feeding with a high energy diet on energy consumption, body weight gain and blood metabolites in these spayed dogs. Four young adult female Beagle dogs were used. Ovariectomy induced a significant decrease of daily energy requirement in dogs. Ad libitum feeding, initiated 6 months after spaying, induced a significant increase in consumption in spayed dogs. This overconsumption was greatest during the first month of ad libitum feeding but continued for the entire 4 months of this period. When fed ad libitum, dogs gained excess body weight without significant effect on plasma cholesterol, triglycerides, glucose and insulin, at short term. These data suggest that energy intake should be strictly controlled to avoid excess weight gain in spayed dogs. [less ▲]

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See detailElectrical machine analysis considering field-circuit-movement and skewing effects
de Oliveira, Ana Margarida; Antunes, R.; Kuo-Peng, Patrick et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2004), 23(4), 1080-1091

This paper presents a method to analyse electrical machines considering simultaneously the electromagnetic field, electric circuit, control loop, movement and skewing effects. The major contribution of ... [more ▼]

This paper presents a method to analyse electrical machines considering simultaneously the electromagnetic field, electric circuit, control loop, movement and skewing effects. The major contribution of this work leans on its generality, i.e. it can be applied to electrical machines connected to static converters submitted to any control laws, avoiding an a priori analysis. Simulation results of a three-phase Brushless AC (BLAC) motor fed by a PWM converter is presented as well as a comparison of simulation and experimental results obtained using a two-phase-on converter were also presented. [less ▲]

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See detailHiv-1 Gp41 And Gp160 Are Hyperthermostable Proteins In A Mesophilic Environment - Characterization Of Gp41 Mutants
Krell, Tino; Greco, Frédéric; Engel, Olivier et al

in European Journal of Biochemistry (2004), 271(8), 1566-79

HIV gp41(24-157) unfolds cooperatively over the pH range of 1.0-4.0 with T(m) values of > 100 degrees C. At pH 2.8, protein unfolding was 80% reversible and the DeltaH(vH)/DeltaH(cal) ratio of 3.7 is ... [more ▼]

HIV gp41(24-157) unfolds cooperatively over the pH range of 1.0-4.0 with T(m) values of > 100 degrees C. At pH 2.8, protein unfolding was 80% reversible and the DeltaH(vH)/DeltaH(cal) ratio of 3.7 is indicative of gp41 being trimeric. No evidence for a monomer-trimer equilibrium in the concentration range of 0.3-36 micro m was obtained by DSC and tryptophan fluorescence. Glycosylation of gp41 was found to have only a marginal impact on the thermal stability. Reduction of the disulfide bond or mutation of both cysteine residues had only a marginal impact on protein stability. There was no cooperative unfolding event in the DSC thermogram of gp160 in NaCl/P(i), pH 7.4, over a temperature range of 8-129 degrees C. When the pH was lowered to 5.5-3.4, a single unfolding event at around 120 degrees C was noted, and three unfolding events at 93.3, 106.4 and 111.8 degrees C were observed at pH 2.8. Differences between gp41 and gp160, and hyperthermostable proteins from thermophile organisms are discussed. A series of gp41 mutants containing single, double, triple or quadruple point mutations were analysed by DSC and CD. The impact of mutations on the protein structure, in the context of generating a gp41 based vaccine antigen that resembles a fusion intermediate state, is discussed. A gp41 mutant, in which three hydrophobic amino acids in the gp41 loop were replaced with charged residues, showed an increased solubility at neutral pH. [less ▲]

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See detailField campaigns: pumping tests and tracer tests
Brouyère, Serge ULiege; Bretotean, Mihai; Minciuna, Marin-Nelu et al

in Hidrotehnica (2004), 49(9-10), 36-50

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See detailHigh protein intake affects lean body mass but not energy expenditure in nonobese neutered cats
Nguyen, Patrick; Leray, Véronique; Dumon, Henri et al

in Journal of Nutrition (2004), 134(8, Suppl. S), 2084-2086

Dietary composition affects body composition; the role of fat and carbohydrates is well documented. Proteins are more satiating than carbohydrates, may produce different effects on glycemia , and are more ... [more ▼]

Dietary composition affects body composition; the role of fat and carbohydrates is well documented. Proteins are more satiating than carbohydrates, may produce different effects on glycemia , and are more thermogenic. Indeed the efficiency of cellular conversion of energy to high-energy yielding phosphate bonds from fatty acids is 90%, from carbohydrates 75%, but only 55% for amino acids. High-protein diets produced greater weight loss in some studies of obese humans but not others. Other human studies found that although the high-protein diet did not promote weight loss in excess of control diets, it did preserve lean tissue mass and promoted the loss of fat tissue . Companion animals also suffer from obesity , and a high-protein, energy-restricted diet was successful in reducing the body weight and body fat of overweight dogs and cats , and in conserving lean body mass of dogs . However, there have been few studies of the effects of protein intake on the body composition in normal-weight individuals of any species. The current study aimed to determine the effect of a limited energy intake of a high-protein diet on the body composition and least observed metabolism (LOM)5 of adult neutered cats. [less ▲]

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See detailLetters to the Editor: Controversies in headache
Bohotin, V.; Schoenen, Jean ULiege

in Cephalalgia : An International Journal of Headache (2004), 24

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See detailHigh-throughput analysis of human serum for selected polychlorinated biphenyls (PCBs) by gas chromatography-isotope dilution time-of-flight mass spectrometry (GC-IDTOFMS)
Focant, Jean-François ULiege; Cochran, Jack W.; Dimandja, Jean-Marie D. et al

in Analyst (2004), 129(4), 331-336

A method for the high-throughput analysis of human serum for the 38 most prevalent polychlorinated biphenyls (PCBs) based on the use of fast gas chromatography-isotopic dilution time-of-flight mass ... [more ▼]

A method for the high-throughput analysis of human serum for the 38 most prevalent polychlorinated biphenyls (PCBs) based on the use of fast gas chromatography-isotopic dilution time-of-flight mass spectrometry (GC-IDTOFMS) is presented. The chromatographic separation time was 8 min. The separation of the congeners was carried out either chromatographically or analytically using the mass spectral deconvolution capability of the TOFMS. The instrument and the method limits of detection (LODs) were 0.5 pg muL(-1) and 20 pg muL(-1), respectively, which is not as good as the one achieved using high resolution mass spectrometry (HRMS) but allows the detection and quantification of the prevalent PCBs present in real human serum samples. The dynamic range covered 3 orders of magnitude. The comparison with the high resolution mass spectrometry (HRMS) reference method (28 min) was good and some separation improvements have been observed. This method allows the analysis of 100 samples per day per instrument. [less ▲]

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See detailEffects of glucocorticoids on the respiratory burst of Chlamydia-primed THP-1 cells.
Mouithys-Mickalad, Ange ULiege; Deby, Ginette ULiege; Mathy, Marianne ULiege et al

in Biochemical and Biophysical Research Communications (2004), 318(4), 941-8

We previously observed that the respiratory burst of human monocytes (THP-1 cell line) triggered by phorbol myristate acetate was strongly enhanced by a priming of the cells by Chlamydia pneumoniae ... [more ▼]

We previously observed that the respiratory burst of human monocytes (THP-1 cell line) triggered by phorbol myristate acetate was strongly enhanced by a priming of the cells by Chlamydia pneumoniae [Biochem. Biophys. Res. Commun. 287 (2001) 781]. We describe here the modifications of the responses of Chlamydia-primed THP-1 cells to hydrocortisone (HCT) and methylprednisolone (MPL). HCT and MPL inhibited the production of the cytokines TNFalpha and IL-8. But HCT, which inhibited the respiratory burst in LPS-primed monocytes, paradoxically stimulated the phenomenon in Chlamydia-primed cells; MPL exerted no significant effect. Both glucocorticoids did not significantly modify the triggering effect of Chlamydia on NF-kappaB binding activity. On the expression of p22(phox), a protein subunit of the NADPH oxidase, HCT had an increasing and MPL a decreasing effect. Glucocorticoids thus had unexpected effects on the inflammatory response of Chlamydia-primed monocytes. [less ▲]

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See detailEtude hydrobiologique des eaux du Taron (Commune de Theux, Province de Liège, Belgique)
Cors, R.; Dethier, Michel ULiege; Fagot, Jean ULiege

in Natura Mosana (2004), 57(1), 1-26

Le ruisseau du Turon est formé par un chevelu complexe de ruisselets provenant de sources et/ou de résurgences, situés pour la plupart à l'ouest du village de La Reid. Ce travail a pour objet l'étude de ... [more ▼]

Le ruisseau du Turon est formé par un chevelu complexe de ruisselets provenant de sources et/ou de résurgences, situés pour la plupart à l'ouest du village de La Reid. Ce travail a pour objet l'étude de la qualité, essentiellement biologique, de ces petits cours d'eau. Il présente les principaux résultats d'un travail de fin d'étude à l'Institut Supérieur d'Agronomie de La Reid (CORS, 2003), mené en près de trente stations, de fin mars 2002 à fin mars 2003. LERUTH (1939) avait déjà étudié les sources de la région et y avait recensé plusieurs espèces stygobies, garantes de la qualité des eaux souterraines. Nous avons tenté de les retrouver. [less ▲]

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See detailSurvivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms.
Chakravarti, Arnab; Zhai, Gary G; Zhang, Min et al

in Oncogene (2004), 23(45), 7494-506

The observed radioresistance of human glioblastoma multiforme (GBM) poses a major challenge, which, if overcome, may lead to significant advances in the management of this patient population. There is ... [more ▼]

The observed radioresistance of human glioblastoma multiforme (GBM) poses a major challenge, which, if overcome, may lead to significant advances in the management of this patient population. There is accumulating evidence from correlative studies that Survivin expression is associated with increased malignant potential of human gliomas. The purpose of this study was to investigate whether Survivin plays a direct role in mediating radiation resistance in primary human glioma cell lines, and, if so, investigating the underlying mechanisms. Our panel of GBM cell lines included two that were relatively radiation resistant (GM20 and GM21) and two that were more radiation sensitive (GM22 and GM23), which demonstrated differential levels of Survivin expression between the two groups. Through the use of adenoviral vectors containing either dominant-negative (pAd-S(T34A)) or wild-type Suvrivin (pAd-S(WT)), we were able to inactivate or overexpress Survivin, respectively. Our findings suggest that Survivin plays a critical role in mediating radiation resistance in primary GBM cells, in part through suppression of apoptotic cell death via a caspase-independent manner. We have identified novel mechanisms by which Survivin may enhance tumor cell survival upon radiation exposure such as regulation of double-strand DNA break repair and tumor cell metabolism, which were most evident in the radiation-resistant cell lines. These differences in Survivin function both in radiation-resistant vs radiation-sensitive cell lines and in the presence vs absence of radiation exposure warrant further investigation and highlight potentially important mechanisms of radiation resistance in these tumors. [less ▲]

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See detailHow CAPE tools can contribute to process sustainability
Kalitventzeff, Boris ULiege; Heyen, Georges ULiege; Closon, Hervé et al

in Journal of Cleaner Production (2004), 12(2), 117-124

The concern of the EFCE for sustainability. Four recent case studies to illustrate how CAPE tools contribute to process sustainability: (1) ultimate plant operation at Wacker-Chemie (DE), (2) development ... [more ▼]

The concern of the EFCE for sustainability. Four recent case studies to illustrate how CAPE tools contribute to process sustainability: (1) ultimate plant operation at Wacker-Chemie (DE), (2) development of a new sulphuric acid plant with Air Liquide (FR), (3) plant retrofit for CO2 abatement at Kemira (BE), (4) insertion of a new plant in an existing Solvay industrial site (Asia). (C) 2003 Published by Elsevier Ltd. [less ▲]

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See detailComparison of sliding-surface and moving-band techniques in frequency-domain finite-element models of rotating machines
De Gersem, Herbert; Gyselinck, Johan; Dular, Patrick ULiege et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2004), 23(4), 1006-1014

The sliding-surface and moving-band techniques are introduced in frequency-domain finite element formulations to model the solid-body motion of the rotors in an cylindrical machine. Both techniques are ... [more ▼]

The sliding-surface and moving-band techniques are introduced in frequency-domain finite element formulations to model the solid-body motion of the rotors in an cylindrical machine. Both techniques are compared concerning their feasibility and computational efficiency. A frequency-domain model of a capacitor motor is equipped with a sliding surface and compared to a transient model with moving band. This example illustrates the advantages of frequency-domain simulation over transient simulation for the simulation of steady-state working conditions of electrical machines. [less ▲]

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See detailEtiologies et exploration electrophysiologique des paralysies diaphragmatiques.
MAERTENS DE NOORDHOUT, Alain ULiege

in Revue Neurologique (2004), 160(12), 1239-44

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See detailDe prosodie van het Frans en van het Nederlands: een contrastieve blik
Rasier, Laurent ULiege

in Handelingen van de Koninklijke Zuid-Nederlandse Maatschappij voor Taal-, Letterkunde en Geschiedenis (2004)

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See detailGenetic diversity of Lima bean in relation with phytogeography in the New World
Baudoin, Jean-Pierre ULiege

in Annals of Arid Zone (2004), 43(3 & 4), 355-376

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See detailOpera latina : une base de données sur internet
Denooz, Joseph ULiege

in Euphrosyne (2004), 32

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