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See detailCustomer-Perceived Intimacy through the Design of Healthscapes
Martens, Carmen ULiege; Delcourt, Cécile ULiege; Herssens, Jasmien

Poster (2019, July)

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See detailFossil Human of Belgium: a review of Quaternary Collections of ULiege
Scavezzoni, Isaure ULiege; Denayer, Julien ULiege

Poster (2019, July)

Palaeoanthropology emerged as a science in the 19th century Belgium. Philippe-Charles Schmerling is notably considered as the first palaeoanthropologist by his pairs. He was the first to survey bone ... [more ▼]

Palaeoanthropology emerged as a science in the 19th century Belgium. Philippe-Charles Schmerling is notably considered as the first palaeoanthropologist by his pairs. He was the first to survey bone deposits in caves around Liège where he discovered in 1830 what he interpreted as the remains of a fossil man different from Homo sapiens. Unfortunately, his fellow scientists were not ready to accept this revolutionary idea and Schmerling’s discoveries were forgotten for over a century. In the 1880s, Prof. Julien Fraipont re-discovered Schmerling’s collection of Quaternary megafauna and subsequently followed the same path when he started to study the cave remains with his colleague Maximin Lohest. Together they described another Belgian celebrity: the ‘Spy Man’ – in fact two incomplete skeleton, identified as a Neanderthalian in 1887. For the first time a fossil man was uncovered from the same horizon than extinct megafauna and Mousterian artefacts. Charles Fraipont, Julien’s son and successor at the Chair of Palaeontology studied Schmerling’s fossils and identified officially the ‘Engis Child’ as the first ever described Neanderthalian. Charles Fraipont created the School of Palaeoanthropology in the 1910s and developed his discipline worldwide. He gathered copies of all fossil human remains known at the time, together with a large amount of anthropological objects. Nowadays, all archaeological and anthropological objects have been split between several institutions but the bulk of the Quaternary megafaunal collection, gathered by these four scientists, is housed in Liège, most of it remains unstudied under modern aspects. [less ▲]

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See detailSearching for interactions at the membrane interface that confer antagonistic activities on floral regulators FT and TFL1
Pottier, Mathieu ULiege; Orman-Ligeza, Beata; Redouté, Gaëlle et al

Poster (2019, July)

In plants, the switch from leaf- to flower-producing meristems is controlled by the FLOWERING LOCUS T (FT) and TERMINAL FLOWER 1 (TFL1) proteins. FT is a major component of the so-called "florigen", a ... [more ▼]

In plants, the switch from leaf- to flower-producing meristems is controlled by the FLOWERING LOCUS T (FT) and TERMINAL FLOWER 1 (TFL1) proteins. FT is a major component of the so-called "florigen", a systemic signal that moves from leaves to shoot meristems and triggers the floral transition. By contrast, TFL1 is expressed in the shoot meristems and represses flowering, antagonising FT. Despite their opposite functions, FT and TFL1 are both members of the same family, showing homology to PHOSPHATIDYLETHANOLAMINE BINDING PROTEINs (PEBPs). They are unable to bind phosphatidylethanolamines though, but bind phosphatidylcholines that are major phospholipids of plant membranes and whose concentration impacts flowering time (Nakamura et al., 2014). The mechanisms by which FT and TFL1 regulate floral transition have been focused on their ability to complex with the transcription factor FD, which itself regulates floral identity genes. However, the loss of FD function does not abolish flowering and hence other interactors remain to be identified. We are therefore investigating in further detail the ability of Arabidopsis FT and TFL1 proteins to interact with membrane lipids and proteins. Langmuir method and molecular dynamics are currently being undertaken to characterize FT and TFL1 interactions with different phospholipids and to simulate their behaviors in contact with membranes, respectively. In parallel, FT and TFL1 protein interactomes are being investigated. We are performing in vitro pulldown assays using His-FT and His-TFL1 as baits and solubilized membranes proteins from cauliflower meristem as preys, taking advantage of the conservation of flowering genes among Brassicaceae. In parallel, complementation of Arabidopsis ft and tfl1 mutants with FT-GS and TFL1-GS constructs allowed us to perform in vivo co-purification analyses. This work will provide us with a better understanding of FT and TFL1 actions and highlight missing checkpoints of the floral transition. [less ▲]

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See detailStratigrapheR: an R package for integrated stratigraphy
Wouters, Sébastien ULiege; Da Silva, Anne-Christine ULiege; Boulvain, Frédéric ULiege et al

Poster (2019, July)

StratigrapheR is an open-source integrated stratigraphy package. It is available in the free software environment R (https://CRAN.R-project.org/package=StratigrapheR) and is designed to manage the large ... [more ▼]

StratigrapheR is an open-source integrated stratigraphy package. It is available in the free software environment R (https://CRAN.R-project.org/package=StratigrapheR) and is designed to manage the large amount of data needed to perform cyclostratigraphy. As this discipline can be carried out by visual analysis on lithological observations and by time-series analyses, StratigrapheR endeavours to link the two by allowing the semi-automated generation of lithologs, the processing of stratigraphical information, and the visualisation of any plot along the lithologs in the R environment. The basic graphical principle behind StratigrapheR is the incremental addition of elements to a drawing: a plot is opened, and graphical elements are successively added. This allows compartmentalisation of the drawing process, as well as the superposition of different plots for comparison. For instance a litholog of a single section can be written as a single function including all the drawing sub-functions, and be integrated in a larger plot, for instance to be correlated to other sections or to show proxy data. The StratigrapheR package is designed for efficient work, and minimum coding, while still allowing versatility. The lithological information of beds (upper and lower boundary, hardness, lithology, etc.) is converted into polygons. All polygons are drawn together using a single function, and each polygon can have its personalised symbology allowing to distinguish lithologies. A similar workflow can be used for plotting proxies while distinguishing each sample by their lithology. Vector graphics can be imported as SVG files, and precisely drawn with the lithologs to serve as symbols or complex elements. Every type of symbol is plotted by calling one single function which repeats the drawing for each occurrence of the represented feature. This illustrates that the amount of work invested to make lithologs using StratigrapheR is related to their complexity rather than their length: a long but monotonous litholog (e.g. of marl-limestone alternations) only takes a few lines of code to generate. The StratigrapheR package also allows basic visualisation and processing of oriented data used for magnetostratigraphy: efficient functions are provided for stereographic projections, Zijderveld plots, conversion between data conventions and reorientation (sample correction, bedding correction, rotation). It also provides a set of functions to deal with selected stratigraphic intervals (for instance in the [0,1[ form): they allow simplification, merging, inversion and visualisation of intervals, as well as identifying the samples included in the given intervals, and characterising the relation of the intervals with each other (overlap, neighbouring, etc.). StratigrapheR includes PDF and SVG generation of plots, of any dimension. The generated PDF can even store multiple plots in a single file (each plot on a different page) to document data processing comprehensively. [less ▲]

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See detailDimensional reduction of a quality of life questionnaire: is confirmatory factor analysis a powerful tool?
Dardenne, Nadia ULiege; POIRRIER, Anne-Lise ULiege; de Dorlodot, Clotilde et al

Poster (2019, July)

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See detailImproving stellar evolution models with atomic diffusion from asteroseismology of intermediate-mass stars
Mombarg, S.G.; Dotter, A.; Thoul, Anne ULiege et al

Poster (2019, July)

One of the biggest enigmas of stellar evolution concerns the transport of chemical elements. As this process is already ill-constrained during the core-hydrogen burning phase, the uncertainties that are ... [more ▼]

One of the biggest enigmas of stellar evolution concerns the transport of chemical elements. As this process is already ill-constrained during the core-hydrogen burning phase, the uncertainties that are introduced propagate into models of more evolved stars. The current state-of-the-art models are not able to predict the observed oscillation frequencies in intermediate-mass stars with their uncertainties. In this talk, we discuss the effect of atomic diffusion (including radiative levitation) on the frequencies of gravity modes and its implications for forward seismic modelling of intermediate-mass stars. Our results show significant differences in frequencies when including atomic diffusion, resulting in different derived masses, ages and metallicities. We will present our findings of our improved forward modelling scheme applied to a slowly rotating pulsator. [less ▲]

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See detailBaseline SNOT-22 as Outcome Predictor: a Powerful Tool just at Hand
POIRRIER, Anne-Lise ULiege; DE DORLODOT, Clotilde; ANSARI, Edward et al

Poster (2019, June 29)

Introduction: SNOT-22 was initially designed for rhinosinusitis, but was recently validated in various nose conditions. We sought to optimize the use of SNOT-22 by predicting the outcome of patients and ... [more ▼]

Introduction: SNOT-22 was initially designed for rhinosinusitis, but was recently validated in various nose conditions. We sought to optimize the use of SNOT-22 by predicting the outcome of patients and healthy volunteers solely based on the pattern of the baseline SNOT-22. Material and Methods: Sixty-six healthy volunteers and 383 patients presenting to the rhinology clinic of 3 ENT academic departments participated in this prospective cross-sectional multi-centre study. SNOT-22 from all participants were collected blindly prior to diagnosis. Participants were then categorized in 4 groups according to their outcome: control, medical rhinologic condition, functional nose surgery, sinus surgery. Difference between groups was assessed by a multinomial logistic regression adjusted for age, gender, history of nose surgery and trauma. Results: The 22 items of SNOT differed significantly among the 4 groups (p <0.05). Control subjects showed the lowest SNOT-22 scores for all items. Patients requiring sinus surgery and those listed for nose surgery exhibited a specific pattern of SNOT-22 score. Nasal and extranasal rhinology symptoms were more specific to the diagnosis than psychological or sleep dysfunction domains. Conclusion: Distinct SNOT-22 patterns were associated to subjects outcome. SNOT-22 was able to differentiate patients from controls, to score severity, and could further provide an accurate description of pathology. Baseline SNOT-22 could help localize pathology in the sinus or in the nose and predict the need for surgical treatment. [less ▲]

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See detailImpact of the European Union directive on driving licences on a Multidisciplinary Sleep Clinic: a Cohort Study
POIRRIER, Anne-Lise ULiege; VERMEIRE, Pierre ULiege; BRUWIER, Annick ULiege et al

Poster (2019, June 29)

Introduction: The threat of Obstructive Sleep Apnea (OSA) for motor vehicle accident has led to a revision of annex III of the European Union directive on driving licences that was implemented in all ... [more ▼]

Introduction: The threat of Obstructive Sleep Apnea (OSA) for motor vehicle accident has led to a revision of annex III of the European Union directive on driving licences that was implemented in all member states from December 31, 2015. In Belgium, it was followed by a shift in funding for OSA from January 1, 2017. Funding was allowed for moderate to severe OSA and the rules shifted for treatments delivery and monitoring by authorised medical opinion. Multidisciplinary Sleep Clinics have long existed, bringing together sleep specialists, dentists, orthodontists and surgeons. We aimed to assess whether a shift in treatment funding was associated with a change in the multidisciplinary sleep practice. Material and Methods: Sample consisted of all patients discussed in the sleep multidisciplinary team meetings of the University Hospital of Liege from January 2016 to December 2018. Interrupted times series, Mann-Whitney U tests and descriptive statistics were produced. Results: There were no differences in patients age, male sex preponderance, body mass index, clinical presentation and level of obstruction. Baseline OSA severity was significantly lower (mean apnea-hypopnea index and mean oxygen desaturation index lowered respectively with p = 0.0189 and p = 0.0466) after the funding rules changed. Oral appliance and ENT surgery were more often offered after the shift in funding. Conclusion: Sleep multidisciplinary team meeting changed patient selection and management after the implementation of the new funding rules for OSA. The shift in funding often resulted in treatment options change, reaching more people and offering more options. [less ▲]

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See detailMutational Effects in Carbapenem Hydrolysis of YEM-1, a New Sub-Class B2 Metallo-beta-Lactamase from Yersinia mollaretii
Mercuri, Paola ULiege; Esposito, Roberto; Blétard, Sylvie et al

Poster (2019, June 22)

Background The genome of Yersinia mollaretii ATCC43969 was totally sequenced (NCBI NZ_AALD0200 0006.1). Its analysis indicated the presence of two β-lactamase genes, namely blaB and yem-1 coding for an ... [more ▼]

Background The genome of Yersinia mollaretii ATCC43969 was totally sequenced (NCBI NZ_AALD0200 0006.1). Its analysis indicated the presence of two β-lactamase genes, namely blaB and yem-1 coding for an AmpC-like and a metallo β-lactamase respectively. Up to date, many studies on BlaB were performed (1,2). Our work aimed to characterize the kinetic profile of YEM-1 and the residues essential for its activity. Methods YEM-1 was produced in E. coli Rosetta and purified to homogeneity. A survey of its kinetic properties was performed against different β-lactam antibiotics. A model of the three-dimensional structure of YEM-1 was build using the known structure of Aeromonas hydrophila CphA as template. Its analysis highlighted the major residues substitution between CphA and YEM-1. These residues were mutated by site-directed mutagenesis. The kinetic properties of the different mutants were analyzed. Results We noted that, at 37°C, YEM-1 is produced as inclusion bodies. We obtained a soluble form of YEM-1 when the culture was grown at 18°C in presence of IPTG 0.1 mM. The MBL was purified in three chromatographic steps that include a HiTRAP SP, an IMAC and a molecular sieve. The kinetic analysis of the YEM-1 showed that only imipenem was hydrolyzed efficiently. We confirmed that it belongs to the subclass B2 MBL family. As expected, the structure of YEM-1 has a similar fold than CphA. We found that the main differences between CphA and YEM-1 were the residues in position 67, 156 and 236 (BBL numbering) respectively. By site-directed mutagenesis, we made the YEM-1 single mutants (Y67V, T156F, S236F), the double mutant T156F-S236F and the triple mutant (Y67T156FS236F) in order to design the active site of CphA in YEM-1. The substitution Y67V yielded a global increase of the catalytic efficiency to carbapenems, with the exception of the imipenem. The mutations of T156 and/or S236 in phenylalanine globally decrease the enzymatic activity of the enzyme. Finally the double mutant and triple mutants did not increase the catalytic efficiencies of YEM-1 against carbapenems. Conclusions Despite a high sequence's similarity between CphA and YEM-1 (57%), we showed that the Yersinia MBL was less effective than CphA against carbapemens. We also highlighted the substitution Y67V in YEM-1 that increased its efficiency against all the carbapemen tested and in particular ertapenem and meropenem. [less ▲]

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See detailIdentification and validation of good practices promoting physical activity, well-being and health through a collaborative didactic engineering approach
Bonni, Jérémy ULiege; Dupont, Jean-Philippe; Benoit, Vercruysse et al

Poster (2019, June 21)

Since 2016, the Wallonia-Brussels Federation (FWB - French speaking part of Belgium) prepares the implementation of a substantial reform of its educational system. One of the axes of that project called ... [more ▼]

Since 2016, the Wallonia-Brussels Federation (FWB - French speaking part of Belgium) prepares the implementation of a substantial reform of its educational system. One of the axes of that project called ‘Pact for Excellence in Education’ (PEE) deals with a deeply modification of the core curriculum that will emphasize 8 domains. Among these domains, one directly involves physical education (PE): “Physical Activities, Wellbeing and Health”. It means that there is a need to redefine PE teachers’ missions and priorities as well as preparing them to implement actions in health education. The Ministry of Education mandated a group of experts from the 12 French-speaking institutions involved in physical education teacher education (PETE) in order to identify, design and share teaching resources respecting the principles advocated by the PEE and aiming to promote physical activity, wellbeing and health. The specificity of the approach is based on the collaboration between teacher educators and practitioners at each step of the project, in line with the collaborative didactic engineering model (Goigoux, 2012; Sénéchal, 2016). The selection of a sample of good practices implemented in FWB and/or other countries (Bonni et al., 2018) was based on evidence or field practice. In addition, the group of experts had also to test several projects in the specific context of the FWB’ schools. Six projects were analyzed : “Development of the playground”, “Nutriathlon”, “Oblomov: move, play, create!”, “PAPS” (Physical Activity Pauses at School), “Dare to save at school”, “Playground layout”. The aim of this presentation is to propose an overview of the data collected at that point.. The latter are expected to be shared on a digital platform managed by the educational authorities. [less ▲]

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See detailInterindividual variability of the teaching-learning needs of student-athletes. A focus on ICT approaches
Bonni, Jérémy ULiege; Denis, Brigitte ULiege; Cloes, Marc ULiege

Poster (2019, June 20)

As sports careers are characterized by a high level of uncertainty, getting a graduation represents a real necessity for most of the athletes. Higher education institutions implement teaching-learning ... [more ▼]

As sports careers are characterized by a high level of uncertainty, getting a graduation represents a real necessity for most of the athletes. Higher education institutions implement teaching-learning supports to help student-athletes dual project. Their interest has been demonstrated (Capranica & Guidotti, 2016) as the conciliation of an academic and an athletic career poses some difficulties (Breithecker, 2018; Gomez, Bradley & Conway, 2018; Semiz, 2018). Among the resources that are proposed, information and communication technologies (ICT) represent a promising approach. Strangely, literature is poor about that topic. This study aimed to analyse the student-athletes opinions concerning the use of ICT in order to determine if there are differences according to some of their characteristics. Data were collected in two steps with student-athletes of the ULiege: (1) 9 of them participated to a semi-structured interview; (2) 30 agreed to answer to an online questionnaire built on the provisional data collected during the previous step. The expectation of using ICT devices in order to meet the needs of this specific group appeared in both parts of the study. Nonetheless, a certain heterogeneity of opinions and expectations was identified. The student-athletes who have the highest expectations about ICT were generally the ones who reported more difficulties in reconciling their dual career (.22 ≥ r ≤ .51, depending on the variables taken into consideration). They have also a highest number of weekly training sessions (.39 ≥ r ≤ .52) and a higher rate of absenteeism due to participation in trainings/competitions (.25 ≥ r ≤ .56). The interindividual variability of the student-athletes’ expectations in terms of ICT underlines that an even more personalized follow-up should be implemented for them in higher education. [less ▲]

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See detailCompact plasmonic multichannel spectroscopic sensor platform
Hastanin, Juriy ULiege; Lenaerts, Cedric ULiege; Gailly, Patrick ULiege et al

Poster (2019, June 18)

we present a hybrid plasmonic sensor architecture, as well as its first experimental proof-of-concept demonstrating its practical feasibility. The proposed approach supports two detection formats on the ... [more ▼]

we present a hybrid plasmonic sensor architecture, as well as its first experimental proof-of-concept demonstrating its practical feasibility. The proposed approach supports two detection formats on the same lab-on-chip device: surface plasmon resonance (SPR) and localized surface plasmon resonance (LSPR) biosensing. The developed instrumental platform is dedicated to multichannel microfluidic biosensing and a specific microfabrication technique involving gold nanoparticles synthesis by pulsed laser writing was developed for the LSPR part. We experimentally demonstrate that the use of the total internal spectroscopic reflectometry can significantly enhance the LSPR sensor sensitivity to refractive index variations of the liquid sample [less ▲]

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See detailIsolation and characterization of a Nannochloropsis salina isolate from Vietnam with potential for biodiesel production
Luu Thao Nguyen, ULiege

Poster (2019, June 17)

In this study, a microalgal strain (nl6) has been isolated in Ninh Thuan province of Vietnam. The 18S rDNA-ITS region (2600 bp) was sequenced, blasted against the NCBI database and found 100% identical ... [more ▼]

In this study, a microalgal strain (nl6) has been isolated in Ninh Thuan province of Vietnam. The 18S rDNA-ITS region (2600 bp) was sequenced, blasted against the NCBI database and found 100% identical with the sequence of an isolate of Nannochloropsis salina (D12, accession number JX185299.1) from Shandong in China. The biomass obtained at log and stationary phase was 0.151 ± 0.005 g/L and 0.603 ± 0.07 g/L, respectively. Fatty acid analysis showed that Nannochloropsis salina nl6 is an oleaginous microalga with fatty acid content of 18.65 ± 1.04 % biomass dry weight (DW) in log phase and 18.17% ± 2.67 % DW in stationary phase. The chain length of fatty acid ranges between C14 – C20. C16:0 is dominant with 33.43 ± 0.28% of total fatty acid (TFA) in log phase and 45.08 ± 2.05% TFA in stationary phase. This leads to the high accumulation of saturated fatty acid in log phase (42.76 ± 0.28 % TFA) and stationary phase (50.46 ± 1.85 % TFA). Saturated fatty acids content is one of the main factors contributing to the fuel properties because higher amount of them will increase the cetane number in fuel. A salinity tolerance experiment has been performed by making growth curves at different salt concentrations (10, 20, 30 and 35 g NaCl/L). Results indicate that Nannochloropsis salina nl6 is highly tolerant to the different salinities analyzed and that the fatty acid profiles are relatively similar. The pigment profile analyzed by HPLC-DAD shows the accumulation of astaxanthin (0.36 ± 0.03 mg/g DW) and cantaxanthin (0.18 ± 0.01 mg/g DW) in stationary phase when nutrient deprivation occurs. This work was supported by ARES (Académie de Recherche et d’Enseignement Supérieur) under the project Renewable. [less ▲]

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See detailCyanobacteria of Polar Regions: Focus of the BCCM/ULC Culture Collection
Ahn, Anne-Catherine ULiege; Beets, Kim ULiege; Lara, Yannick ULiege et al

Poster (2019, June 13)

In the Polar Regions, Cyanobacteria represent key primary producers and are the main drivers of the food webs in a wide range of aquatic to terrestrial habitats. They build benthic microbial mats in lakes ... [more ▼]

In the Polar Regions, Cyanobacteria represent key primary producers and are the main drivers of the food webs in a wide range of aquatic to terrestrial habitats. They build benthic microbial mats in lakes and soil crusts in terrestrial biotopes. They may present interesting features to survive freeze/thaw cycles, seasonally contrasted light intensities, high UV radiations, dessication and other stresses. The BCCM/ULC public collection funded by the Belgian Science Policy Office since 2011 aims to gather a representative portion of the polar cyanobacterial diversity with different ecological origins (limnetic mats, soil crusts, cryoconites, endoliths…). It makes it available for researchers to study the taxonomy, evolution, adaptations to harsh environmental conditions, and genomic make-up. It presently includes 224 cyanobacterial strains, with 140 being of Antarctic origin (catalogue: http://bccm.belspo.be/catalogues/ulc-catalogue-search). An ISO 9001 certificate was obtained for the public deposition and distribution of strains, as part of the multi-site certification for the BCCM consortium. The morphological identification shows that the strains belong to the orders Synechococcales, Oscillatoriales, Pleurocapsales, Chroococcidiopsidales and Nostocales. The 16S rRNA and ITS sequences of the strains are gradually being characterized. The 159 BCCM/ULC strains for which 16S rRNA sequences were analyzed correspond to 69 OTUs (sequences with > 99 % 16S rRNA similarity), and thus, represent a quite large diversity. In addition, cyanobacteria are known to produce a wide range of secondary metabolites (e.g. alkaloids, cyclic and linear peptides, polyketides) with bioactive potential. Genome sequencing was performed for 15 strains (Lara et al. 2017, Cornet et al. 2018). The bioinformatic analysis of the partial genomes of strains ULC007, ULC065 and ULC129 showed the presence of clusters encoding NRPS, PKS, hybrid clusters and other types of secondary metabolites. The comparison of a selection of the PEGs involved in the cold adaptation mechanisms revealed that more copies of PEGs involved in various molecular mechanisms of cold stress responses have been found in polar than in non polar genomes. In summary, the BCCM/ULC public collection serves as a Biological Resource Centre to conserve ex situ and document the biodiversity of polar cyanobacteria, as well as a repository for discovery of novel bioactive compounds. [less ▲]

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See detailAuteurs d'Infraction(s) à Caractère Sexuel : passage à l'acte, recherche de bien-être et GLM
Dziewa, Amandine ULiege; Glowacz, Fabienne ULiege

Poster (2019, June 13)

La délinquance sexuelle et les délinquants sexuels ont souvent été analysés en termes de risque de récidive. Mais depuis une dizaine d’années plusieurs modèles considèrent la notion de bien-être comme une ... [more ▼]

La délinquance sexuelle et les délinquants sexuels ont souvent été analysés en termes de risque de récidive. Mais depuis une dizaine d’années plusieurs modèles considèrent la notion de bien-être comme une clé de compréhension ; notamment le Good Live Model (GLM) ou l’Integrate Theory of Desistance from Sex Offending (ITDSO). Cette recherche propose d’appréhender l'infraction sexuelle par la recherche du bien-être. Pour répondre à la question « le passage à l’acte sexuel s’inscrit-il dans une démarche de recherche de bien-être ? » un échantillon de 30 hommes Auteurs d’Infraction(s) à Caractère Sexuel (AICS) jugés et en suivi psychologique depuis minimum 1 an a été rencontré. Cinq variables ont été analysées au moyen de questionnaires auto-administrés : le bonheur (Oxford Happiness Questionnaire, Argyle & al., 1989), la qualité de vie (Profil de qualité de vie subjective, Quérin et al., 1991) l’auto-efficacité (Echelle d’Auto-Efficacité, Jérusalem et Schwarzer, 1922), le stress perçu (Perceived Stress Scale, Cohen et al., 1983) et la dépression (Indice de Dépression, Beck et al., 1983). En outre, un entretien semi-structuré a permis d’appréhender la notion de bien-être subjectif et la qualité de vie au moment du passage à l’acte et au moment de la passation de l’entretien. Les questions posées abordaient (1) la situation émotionnelle de la personne avant le passage à l’acte ; (2) sa perception du passage à l’acte, les précipitants et les impacts ainsi que (3) la définition de ce qui fait son bonheur. Les résultats mettent en avant que la majorité des AICS rencontrés considèrent la période de l'agression sexuelle comme stressante et insatisfaisante, surtout dans les sphères familiales et relationnelles. Sphères pourtant centrales dans leur définition du bonheur. Cela rejoint les fondements du Good Lives Model selon lesquels le délit sexuel peut-être le résultat d’une cherche - problématique - de besoins humains légitimes pour atteindre, in fine, un état de bien-être. Plus particulièrement, les résultats renvoient à la notion de « deuxième route » de la Théorie du Good Lives Model Compréhensive qui considère que la frustration d’un échec dans la poursuite de Primary Goods sous-tendrait le passage à l’acte. [less ▲]

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See detailFunctional reorganization after surgical hemispherotomy for intractable epilepsy
Demertzi, Athina ULiege; Blauwblomme, Thomas; Tacchela, Jean-Marc et al

Poster (2019, June 12)

Introduction: Epilepsy is a chronic neurological condition characterized by seizures that may lead to transient loss of consciousness (1). Hemispherotomy is a surgical procedure which isolates the ... [more ▼]

Introduction: Epilepsy is a chronic neurological condition characterized by seizures that may lead to transient loss of consciousness (1). Hemispherotomy is a surgical procedure which isolates the affected hemisphere, hence leading to seizure freedom. Despite acceptable neurological outcome, cerebral functional reorganization especially of the isolated hemisphere remains debatable. We aimed at exploring plasticity changes after hemispherotomy. We expected no cortical inter-hemispheric transfer of functional connectivity as a result of the structural disconnection between the two hemispheres. We further hypothesized that plasticity would involve cerebellopontino-thalamocortical routes involving the remaining functional hemisphere. Methods: Patients showed drug-resistant lesional epilepsy associated with Rasmussen encephalitis and hemimegalencephaly. They were operated by a midline vertical hemispherotomy (2): complete callosotomy was performed, allowing access to the lateral ventricles. Perithalamic section of the white matter between the frontal and temporal horn disrupted the internal capsule,  mbria, anterior commissure, but left the major intra-hemispheric bundles (superior and inferior longitudinal fasciculi, uncinated fasciculus, cingulum, external capsule) untouched. With this procedure the affected right hemisphere was isolated. MRI was performed 39m after surgery for patient1 (P1) and 31m after surgery for patient 2 (P2). Pseudo-Continuous Arti cial Spin Labelling (ASL) and 300 functional MRI volumes during resting condition were acquired on a GE Sigma 1.5T scanner. Age- and gender-matched control data were used from the National Database for Autism Research (NDAR) (http://ndar.nih.gov). ASL analysis included segmentation, brain extraction, normalization to a 7y-old brain Atlas obtained with Template-OMatic Toolbox, coregistration, realignment, normalization using the deformation  elds obtained during the T1 normalization, and smoothing (10 mm isotropic filter).FMRI analysis included slice-time correction, realignment, segmentation of structural data, normalization of functional and structural data into standard MNI space, smoothing (6mm FWHM) and denoising (cCompCor, regression of motion paramaters, temporal filtering 0.008- 0.09Hz). Functional connectivity was performed using patient-specic spherical regions of interest at the cortical subcortical level. Results: In both patients, the disconnected right hemisphere (RH) showed general hypo-perfusion, and the preserved left hemisphere (LH) had hyper-perfusion mainly in motor and temporal areas. Neither patient showed inter-hemispheric transfer of functional connectivity. Thalamo-cortical connectivity was preserved only in the LHs. Intercerebellar connectivity was present but cerebello-cortical crossings were preserved only in the LHs. P2 further showed right-sided ipsilateral cerebello-cortical connectivity, which was mediated by the effect of the vascular system. Both patients' brain showed preserved yet lateralized network-level organization. Conclusions: After hemispherotomy the two hemispheres function in a disconnected manner. The isolated brain is resilient to support intrinsic functional connectivity which is mediated, yet not fully explained, by the effect of vascularization. These data are relevant for a better comprehension of functional organization after neurosurgery and raise inquiries about the cognitive role of the isolated right hemisphere. [less ▲]

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See detailPIXE-PIGE and Proton Activation Analysis of Analysis of Roman archeological artefacts
Strivay, David ULiege; Chene, Grégoire ULiege; Dienst, Simon ULiege et al

Poster (2019, June 11)

A combination of 3MeV proton PIXE-PIGE, MA-XRF and 10-15 MeV proton activation analysis has been recently applied on the external beam line of the cyclotron of IPNAS/CEA laboratory from the University of ... [more ▼]

A combination of 3MeV proton PIXE-PIGE, MA-XRF and 10-15 MeV proton activation analysis has been recently applied on the external beam line of the cyclotron of IPNAS/CEA laboratory from the University of Liège, and thus, to a wide variety of archaeological specimens (glass, pottery (terra sigillata), mortars and pigments) all provided by on-going studies and excavations of housing materials, wall decorations, and vessels led on two remarkable Roman sites: First, from an important agricultural complex excavated on an artificial terrace from a republican town, Artena, located, 40 km South-East from Rome, near the Via Latina and the Campania and second, from the Domus dei bucrani, a house dating from the end of the Republican era discovered on the site of the Schola of the Trajan in Ostia. The aim of the present work is to explore and report the specific analytical interests of Charge Particle Activation Analysis implemented with protons ranging from 10 to 15 MeV, as a non-invasive analytical technique for the detection of elements with Z = 11-40 and beyond, and to address its suitability to solve questions raised by archaeologists. We present in this paper the preliminary results obtained following methodologies reported in recent pioneering and more recent works1-4 and emphasize on the achieved sensitivities (Limits of Detections) for elements as Ca, Ti, V, Cr, Fe, Cu, Zn, As, Sr, Y, Zr and Sb ranging from percentage to parts per million (ppm) levels. [less ▲]

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See detailVidéos 360° : Validation d'un nouvel outil de mesure de la paranoïa dans la population générale.
Della Libera, Clara ULiege; Quertemont, Etienne ULiege; Laloyaux, Julien ULiege et al

Poster (2019, June 06)

Introduction : Depuis une quinzaine d’années, la réalité virtuelle est utilisée comme nouvel outil pour étudier la paranoïa. Un tel dispositif est cependant coûteu et requiert la modélisation d’avatar peu ... [more ▼]

Introduction : Depuis une quinzaine d’années, la réalité virtuelle est utilisée comme nouvel outil pour étudier la paranoïa. Un tel dispositif est cependant coûteu et requiert la modélisation d’avatar peu réalistes en termes d’expressions faciales et corporelles. Une alternative intéressante est l’utilisation de vidéos 360° permettant la création d’environnements immersifs plus accessibles et écologiques. L’objectif de cette étude est de valider l’utilisation de vidéos 360° comme nouvelle mesure de la paranoïa dans la population générale. Méthode : Un bar, un ascenseur et une bibliothèque ont été filmés avec 4 à 15 acteurs afin de représenter une situation de vie quotidienne. Cent septante participants ont été évalués sur leur tendance générale à la paranoïa (trait) avant d’être insérés dans l’une des vidéos à l’aide d’un casque Oculus Go. Les participants ont ensuite complété une mesure de paranoïa état, une mesure du sentiment de présence et répondu à un entretien semi-structuré interrogeant leurs interprétations des interactions perçues au sein des vidéos. Résultats : Dans l’ascenseur et la bibliothèque uniquement, les résultats montrent que les participants développent un sentiment de présence au sein des vidéos. De plus, de bonnes corrélations entre la paranoïa trait et la paranoïa état indiquent une bonne validité convergente de la mesure. Enfin, les participants avec un haut score de paranoïa trait rapportent des intentions malveillantes à leur égard de la part des acteurs durant l’entretien semi-structuré. Conclusion : La présente étude valide l’utilisation de vidéos 360° pour l’étude de la paranoïa. [less ▲]

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See detailDevelopment of bimetallic nanoparticles for Surface-Assisted Laser Desorption/Ionisation Mass Spectrometry imaging of small molecules
Verdin, Alexandre ULiege; Malherbe, Cédric ULiege; Bertrand, Virginie ULiege et al

Poster (2019, June 04)

Mass Spectrometry Imaging (MSI) allows the simultaneous visualisation of hundreds to thousands of molecules in biological tissue slides enabling the comprehension of complex biochemical processes ... [more ▼]

Mass Spectrometry Imaging (MSI) allows the simultaneous visualisation of hundreds to thousands of molecules in biological tissue slides enabling the comprehension of complex biochemical processes. Additionally, the analysis of untargeted MSI data with advanced statistical tools has the potential to reveal pertinent features of the sample such as the progression or outcome of a disease or the response to a treatment. Recently, metallic nanoparticles (NPs) have received increasing attention as desorption/ionization substrate for Surface-Assisted Laser Desorption/Ionization-MS (SALDI-MS). Metallic NPs provide several advantages over organic MALDI matrices for the analysis of small molecules: high absorption coefficients of the ionization laser (in the UV-Visible range), the ability to load small molecules on their surface by physical or chemical adsorption, little interferences in the low m/z range and a simple sample preparation (no crystallization required). SALDI-MSI is adapted to study the variations of the molecular composition associated with various diseases and to visualize the localization of pertinent small molecules in complex biological tissues. Innovative Au@Ag (core@shell) bimetallic NPs are interesting for SALDI applications, especially because controlling the thickness of the Ag shell around the Au core allows the tuning of the absorption in near-UV. These Au@Ag NPs permits to maximize the energy absorption for an efficient ionization and desorption of analytes adsorbed to the NPs. Moreover Au@Ag NPs can also be used for Surface-Enhanced Raman Spectroscopy (SERS) imaging which is a highly complementary technique. We report here a study of ovarian cancer tissue using Au@Ag NPs to characterize the overexpression of membrane receptor in the tumor by SERS imaging and to gain molecular insights by SALDI-MSI. [less ▲]

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See detailA nearly corotating long lasting auroral spiral at Saturn
Palmaerts, Benjamin ULiege; Yao, Zhonghua ULiege; Sergis, N. et al

Poster (2019, June 04)

The main ultraviolet auroral emission at Saturn consists of multiple structures of various sizes forming a discontinuous ring of emissions around Saturn’s poles. For decades, it is known that the main ... [more ▼]

The main ultraviolet auroral emission at Saturn consists of multiple structures of various sizes forming a discontinuous ring of emissions around Saturn’s poles. For decades, it is known that the main emission is occasionally organized in a global spiral surrounding the pole. In August 2016, the Ultraviolet Imaging Spectrograph (UVIS) on board the Cassini spacecraft proceeded to a 7h-long imaging of Saturn’s northern aurora. During this observing sequence, the main emission displayed a spiral wrapping around the pole by more than 370° in longitude. The spiral was in rotation around the pole at ~90% of rigid corotation, which is an unusually high velocity for extended auroral structures. A spiral was again observed during a shorter UVIS sequence, sixteen hours after the end of the first sequence. Simultaneously to the first UVIS sequence, imaging of the energetic neutral atom (ENA) emissions revealed a hot plasma population in the same local time sector as the extremity of the UV spiral. The leading edge of the plasma population follows the spiral structure around the planet. This correspondence suggests that the presence of the hot plasma distorted the magnetospheric current system, resulting in the spiral shape of the main emission. Furthermore, simultaneous in-situ measurements of the ion fluxes exhibit enhancements recurring every ~10.5 hours. The nearly corotating aurora, ENA emissions and ions revealed by this multi-instrument dataset are likely three signatures of a magnetosphere-ionosphere coupling current system and of the associated hot plasma population corotating with the planet. [less ▲]

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See detailThe quest for the best cell factory for recombinant protein production: Yarrowia lipolytica vs Pichia pastoris
Vandermies, Marie ULiege; Theron, Chrispian ULiege; Fickers, Patrick ULiege

Poster (2019, June 04)

In the present study, the performances of the emerging cell factories Y. lipolytica and P. pastoris were compared for their ability to synthetize and secrete recombinant proteins in bioreactors. As a case ... [more ▼]

In the present study, the performances of the emerging cell factories Y. lipolytica and P. pastoris were compared for their ability to synthetize and secrete recombinant proteins in bioreactors. As a case study, the lipase CalB from Candida antarctica was cloned under the control of the strong inducible promoters pEYK300A3B and pAOX1 and expressed in Y. lipolytica EYK1ko and P. pastoris MutS recipient strains, respectively. Surprisingly, Y. lipolytica performances were far superior in terms of cell growth, extracellular lipase activity, although P. pastoris showed a significantly higher level of CalB gene expression. According to our results, neither of codon usage bias, protein processing and secretion, or CalB lipase inactivation could be incriminated. It is therefore hypothesized that the observed difference lies in post-translational mechanisms activated by the overexpression of recombinant proteins, namely the unfolded protein response (UPR) and the endoplasmic reticulum (ER) associated degradation (ERAD). Here indeed, the proteasome was shown activated in P. pastoris following recombinant protein expression. In conclusion, keeping specific process constraints in mind, the selection of the adequate cell factory can dramatically improve the production of a given recombinant protein. [less ▲]

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See detailStools lipid profiling by HILIC LC-MS/MS
Hustin, Justine ULiege

Poster (2019, June 03)

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See detailProbing hippocampus’ functional properties with activation databases
Genon, Sarah ULiege; Plachti, Anna; Pinho, Ana Luisa et al

Poster (2019, June)

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See detailVirulotyping of Shiga toxin-producing (STEC) and enteropathogenic (EPEC) Escherichia coli isolated from recto-anal mucosal swabs of young diarrheic and non-diarrheic calves
Habets, Audrey ULiege; Duprez, Jean-Noël ULiege; Engelen, Frédéric et al

Poster (2019, June)

Shiga toxin-producing Escherichia coli (STEC) are food-borne pathogens causing severe disease in humans worldwide, whose most important virulence factor is the production of Shiga toxins (Stx1, Stx2 ... [more ▼]

Shiga toxin-producing Escherichia coli (STEC) are food-borne pathogens causing severe disease in humans worldwide, whose most important virulence factor is the production of Shiga toxins (Stx1, Stx2). Additionally, most STEC also possess the eae gene encoding for the intimin protein, which is responsible for the formation of the attaching and effacing (A/E) lesions (AE-STEC) and is also typical of enteropathogenic E. coli (EPEC). AE-STEC colonize the mucosa of the recto-anal junction of healthy adult cattle, making recto-anal mucosal swabs (RAMS) more sensitive than fecal culture to isolate them. In addition, AE-STEC also colonize the small and large intestines of young calves causing diarrhea. Conversely, the carrier state of non-diarrheic young calves is unknown. Finally, most studies address the most pathogenic O157:H7 AE-STEC serotypes, although several other non-O157:H7 AE-STEC serotypes are becoming increasingly important with regard to human outbreaks. The objective of the present study was to evaluate the colonization by and shedding of AE-STEC in young diarrheic and non-diarrheic dairy calves. RAMS from 233 young calves in 3 farms with non-O157:H7 AE-STEC in older animals were overnight enriched in Lauryl-Sulfate broth and tested with a triplex PCR targeting the eae, stx1 and stx2 genes. Positive broths were subsequently streaked on four selective agar plates (Figure 1). Up to 5 colonies per plate will be picked-up, tested by the colony hybridization assay with probes for the same genes and confirmed by the same triplex PCR.A total of 152 broths (65%) tested positive with the triplex PCR after overnight enrichment: 23 AE-STEC, 122 STEC and 7 EPEC. In farm #1, 2 RAMS tested positive for AE-STEC, 45 for STEC and 3 for EPEC. In farm #2, 3 RAMS tested positive for AE-STEC, 42 for STEC and 4 for EPEC. In farm #3, 18 RAMS tested positive for AE-STEC and 35 for STEC. All positive broths are being streaked on the selective agar plates and the 5 picked-up colonies are being prepared for the colony hybridization assay. Of the positive RAM’s the majority (80%) harbored STEC and a minority AE-STEC (15%) or EPEC (5%). This low number of EPEC-positive samples is different from previous results obtained in adult cattle in two slaughterhouses following the same methodology. In the same survey, 80% of the PCR-positive broths gave colony hybridization-positive and triplex PCR-positive colonies. Confirmed positive colonies will be O:H serotyped by PCR and all results will be associated with presence/absence of diarrhea in the calves. [less ▲]

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See detailDifferent factorisation approaches of the Delis-Kaplan Executive System Battery converge towards a bi-factor model
Camilleri, Julia; Weis, Susanne; Chen, Ji et al

Poster (2019, June)

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See detailWhole Plant Phenotyping and Molecular Identification of Zn Transporters During Zn Deficiency and Excess in Brachypodium distachyon
Amini, Sahand ULiege; Arsova, Borjana; Watt, Michelle et al

Poster (2019, June)

Zinc (Zn) is an essential micronutrient for plants and around two billion people are depending on legumes and grains as their main Zn source. This transition metal is however toxic for plants at high ... [more ▼]

Zinc (Zn) is an essential micronutrient for plants and around two billion people are depending on legumes and grains as their main Zn source. This transition metal is however toxic for plants at high concentrations in soils and affects biomass and yield. The eudicot model plant Arabidopsis thaliana has already been characterized for Zn homeostasis under various Zn regimes and recently we have investigated the transcriptome, proteome and ionome upon Zn deficiency and re-supply in this species (Arsova, B. et al., 2019, bioRxiv, 600569). Although some important players of Zn uptake and transport, such as ZRT, IRT-like Protein (ZIP) family genes, have been studied in wheat, rice and barley, it is unclear how different or similar are the responses of monocots and dicots to Zn supply at the molecular level. In the current study, we aim at characterizing Zn regulation in the model plant Brachypodium distachyon. For this, 10-day-old Brachypodium plants were treated with high- and low-Zn medium for two and three weeks. We measured root length, shoot weight and leaf area to examine how Zn supply influences Brachypodium morphology. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) analysis was performed to determine Zn and other metal ion distribution in root and shoot under different Zn treatments. Quantitative RT-PCR analysis of 20 genes orthologous to Arabidopsis Zn homeostasis genes revealed their expression pattern in response to Zn depletion and surplus. We observed the most commonality between Brachypodium and Arabidopsis, as well as the highest correlation between Zn content and gene regulation, for ZIP genes. In general, our results show that comparative molecular study can be useful to reveal the Zn regulatory mechanisms in monocots, which can lead to new Zn biofortification and stress resistance strategies in vital grains. [less ▲]

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See detailProbing the Mechanochemical Properties of a Single Molecular Knot by AFM
Sluysmans, Damien ULiege; Zhang, Liang; Song, Yiwei et al

Poster (2019, June)

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See detailCooperative catalysts for the selective synthesis of alkylidene cyclic carbonates from CO2 and propargylic alcohols
Ngassam Tounzoua, Charlène ULiege; Grignard, Bruno ULiege; Jérôme, Christine ULiege et al

Poster (2019, June)

Carbon dioxide (CO2) is a greenhouse gas responsible for global warming. In the last decades, efforts have been put towards the valorization of this abundant, nontoxic inexhaustible C1 source for the ... [more ▼]

Carbon dioxide (CO2) is a greenhouse gas responsible for global warming. In the last decades, efforts have been put towards the valorization of this abundant, nontoxic inexhaustible C1 source for the synthesis of useful commodity chemicals such as methanol, methane, carboxylic acids, urea, synthetic fuel and cyclic carbonates. Amongst those, the synthesis of cyclic carbonates is attracting much interest due to its 100% atom efficiency reaction and its large potential scope for the design of complex organic molecules or novel functional polymers (polycarbonates, polyurethanes, etc.). 5-membered cyclic carbonates can be obtained by the coupling of CO2 with diols, epoxides and lastly, alkynols. The latter have the advantage of affording cyclic carbonates that are activated by the presence of an exocyclic vinylic bond, making them reactive towards alcohols and amines. In addition, their ring-opening is regio-selective affording β-oxo-carbonate by reaction with alcohols, ß-oxo-urethanes with secondary amines or ß-hydroxy-oxazolidones with primary amines. Due to the inertness and high thermodynamic stability of CO2, a catalyst is required to transform alkynols into alkylidene cyclic carbonates. Bases, ionic liquids), carbenes, metal salts, have been shown to promote the cyclisation of CO2 with alkynols. Although full conversions are obtained in certain cases, the selectivity remains an issue. Also, harsh conditions and/or excessive amounts of base are often used. In this work, we designed novel, cheap, highly efficient organocatalysts for the synthesis of α-alkylidene cyclic carbonates from CO2 and alkynols. Several organocatalysts, based on ammonium cations and basic anions were screened, and kinetic studies were performed by Raman spectroscopy to identify the best anion/cation couple. We further optimized our catalytic system by developing cooperative catalysts providing conditions for the selective formation of α-alkylidene cyclic carbonates under mild experimental conditions and short reaction times at very low catalyst loading. [less ▲]

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See detailNanoLuX: a network-wide Nanoluciferase-based platform to monitor activation of classical and atypical chemokine receptors
Meyrath, Max Marc Roger ULiege; Reynders, Nathan; Counson, Manuel et al

Poster (2019, June)

The activity of chemokine receptors is dependent on G proteins that, upon chemokine binding, trigger various intracellular signalling cascades, as well as on b-arrestins that, following receptor ... [more ▼]

The activity of chemokine receptors is dependent on G proteins that, upon chemokine binding, trigger various intracellular signalling cascades, as well as on b-arrestins that, following receptor phosphorylation by GRK, orchestrate its desensitization, endocytosis and trafficking. In addition to the 19 classical chemokine receptors, 4 receptors form a subfamily of atypical chemokine receptors (ACKR1-4) with ligand scavenging functions (Fig 1). These receptors are unable to couple to G proteins but their activity can be monitored via b-arrestins. In this study we describe the NanoLux platform, a network-wide profiling platform for chemokines and chemokines receptors based on the complementation of the nanoluciferase (NanoBiT). This platform allows to monitor the activation, modulation or bias of receptors or ligands by measuring the binding or the recruitment of effectors, regulators or parners such as G proteins, GRK or b-arrestin isoforms to the classical and the atypical chemokine receptors. For that purpose, we N-terminally fused the LgBiT portion of Nanoluciferase to the MiniGi protein, GRK2 or human b- arrestin 1 and 2, while the SmBiT was fused to the C terminus of all of the 23 human chemokine receptors (Fig 2). Using this approach, we are now able to assess and compare the activity of molecules at the chemokine-receptor network level. [less ▲]

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See detailComputational chemistry and ion mobility – mass spectrometry at high resolving power suggest prototropism of cyclic lipopeptides
Mc Cann, Andréa ULiege; Kune, Christopher ULiege; Far, Johann ULiege et al

Poster (2019, June)

Introduction Cyclic lipopeptides (CLPs) are cyclic hydrophilic peptides with a lipid ramification using a β-hydroxy fatty acid that are produced by bacteria in a ribosome independent manner. Despite CLPs ... [more ▼]

Introduction Cyclic lipopeptides (CLPs) are cyclic hydrophilic peptides with a lipid ramification using a β-hydroxy fatty acid that are produced by bacteria in a ribosome independent manner. Despite CLPs have relatively low molecular weight between 800 and 2,000 Da, the analysis of lipopeptides remains challenging due to the wide variety of synthetized isoforms differing in fatty acid chain length, in methyl group branching position, and in the nature of the amino-acids residues. These isoforms are suspected to have different biological activities requiring development of reliable methods for CLPs characterization. We present here an original approach combining UPLC and ion mobility - mass spectrometry at high resolving powers to separate the different species. Experimentally determined CCS will be compared with theoretical ones. Methods Lipopeptides were separated by UPLC (I-class, Waters, U.K.) on a C18 BEH column and identified by CID MS/MS mass spectrometry. Ion mobility – mass spectrometry (IM-MS) measurements were performed on a traveling wave ion mobility mass spectrometer (Synapt G2 HDMS from Waters, U.K.) and on a trapped Ion Mobility Mass Spectrometer (timsTOF, Bruker Daltonics, U.S.A.) to investigate the 3D structures of the ionized lipopeptides. Accurate Collison Cross Section (CCS) were obtained in both positive and negative mode and compared with theoretical CCS. Density Functional Theory (Gaussian) was used for structure optimizations at the CAM-B3LYP level of theory and 3-21G as basis set. Theoretical CCS have been computed from optimized structures using the trajectory method from IMoS V2. Preliminary data Separation of lipopeptides such as surfactins was successfully performed by reverse phase liquid chromatography. Lipopeptides were separated according to lipidic chain length and the branching position of the methyl group (iso/anteiso/linear). In positive ionization mode, the infusion of each isolated isoforms in the Synapt G2 showed a broad IMS distribution. These ion mobility profiles suggested the presence of different conformers. The higher IMS resolving power of the TIMS allowed the detection of at least three near-resolved peaks for a single isomer. In negative ionization mode however, only one peak was observed in the IM-MS profile on both Synapt G2 and TIMS, corresponding to one CCS. We included prototropic hypotheses where all the potential protonation and deprotonation sites on each lipopeptide had been determined by theoretical calculation. The abundances of the species in the CCS distributions of the resulting structures were obtained based on the Boltzmann distribution. Regarding the surfactin family, preliminary calculations by DFT shows that several protonation sites are energetically favorable and that the proton localization has a significant effect on the resulting CCS (∆CCS = 10Ų). These results are in good agreement with the experimental IMS profiles, obtained in both positive and negative ionization mode. Lipopeptides are then not related to a unique CCS value but a set of IM-MS profile that probably contains additional structural and physicochemical information. Novel aspect Experimental and theoretical approaches for lipopeptides IMS profiles analysis: protonation site determination, peaks intensity prediction and structural information extraction. [less ▲]

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See detailArchitectural and developmental changes due to overexpression of the JOINTLESS gene in tomato
Huerga Fernandez, Samuel ULiege; Orman-Ligeza, Beata; Périlleux, Claire ULiege

Poster (2019, June)

Inflorescence architecture shows huge variation among flowering plants, especially in the amount of flowers and branching degree. In tomato, the formation of the inflorescence follows a sympodial pattern ... [more ▼]

Inflorescence architecture shows huge variation among flowering plants, especially in the amount of flowers and branching degree. In tomato, the formation of the inflorescence follows a sympodial pattern : the shoot apical meristem (SAM) acquires a floral meristem (FM) fate and forms the first flower while a lateral inflorescence meristem (IM) is initiated, which itself matures into a FM when a second IM is initiated, and so on. This sympodial mode of inflorescence development is regulated by a complex genetic network, which remains to be elucidated. Tomato is also used as a model in the study of abscission, an important process by which plants can isolate and drop different parts such as non fertilized flowers, damaged organs or ripe fruits. The lack of fruit abscission zone – the “jointless” phenotype – is associated with the j and j-2 mutations, which impair the function of two MADS-box genes: JOINTLESS (J) and SlMBP21. We are interested in understanding the functions of J, because j knock-out mutation does not only alter the abscission zone but causes inflorescence reversion to leaf production after the initiation of few flowers. Our goal is therefore to identify the targets of J by different molecular approaches. [less ▲]

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See detailImplementation and follow-up of a project aiming to promote physical activity in overweight adolescents
Rompen, Jérôme ULiege; Lepage, Sarah ULiege; Cloes, Marc ULiege

Poster (2019, June)

Background and purpose For a few years, the Department of Sport and Rehabilitation Sciences of the University of Liege has organized physical activity (PA) promotion events for overweight children and ... [more ▼]

Background and purpose For a few years, the Department of Sport and Rehabilitation Sciences of the University of Liege has organized physical activity (PA) promotion events for overweight children and adolescents. One of the biggest difficulties has always been a lack of adherence and participation in these activities. According to the Self‐determination Theory, exercise programs designed to satisfy the need for autonomy, competence and relatedness might increase PA adherence and promote a long‐lasting active lifestyle (Deforche, Haerens & Bourdeaudhuij, 2011). The first purpose of this study was to implement a project aiming to promote physical activity in overweight adolescents. It consisted in 2 series of 8 collective PA sessions, leading to a team participation in a public charity sport event. The sessions included aerobic and resistance exercises as well as educational content. This study also aimed to evaluate the motivation of the participants for this project and its impact on their lifestyle. Methods 15 overweight adolescents voluntarily participated in this study (aged 12 to 18 years). Data were collected using a questionnaire and interviews before and after the program. A short questionnaire was also completed by the participants and the instructor at the end of each PA session. Results After the first 8 sessions, no dropout has been observed and the attendance rate reached 79.2%. Moreover, the motivation level of the participants regarding the sessions seemed high. On a scale of 0 to 5, it reached an average of 3.71+-0.49 and 4.17+- 1.3, from the point of view of the instructor and the participants, respectively. Conclusions and implications These preliminary findings are encouraging to continue with the project. Future data will allow us to analyze the evolution of motivation and adherence of the participants through the program and to evaluate its impact on PA habits of the participants. [less ▲]

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See detailForensic chemical ecology: how do necrophagous insects impact and react to the smell of a cadaver?
Martin, Clément ULiege; Boullis, Antoine; Vanderplanck, Maryse et al

Poster (2019, June)

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See detailIdentification of non-conventional serotypes of enteropathogenic Escherichia coli (EPEC) isolated from diarrheic calves
Habets, Audrey ULiege; Duprez, Jean-Noël ULiege; Saulmont, Marc et al

Poster (2019, June)

Enteropathogenic Escherichia coli (EPEC) are subdivided into “typical (t) EPEC” producing the “Bundle Forming Pili” (BFP) type 4 fimbriae and isolated from humans, and “atypical (a) EPEC” not producing ... [more ▼]

Enteropathogenic Escherichia coli (EPEC) are subdivided into “typical (t) EPEC” producing the “Bundle Forming Pili” (BFP) type 4 fimbriae and isolated from humans, and “atypical (a) EPEC” not producing the BFP and isolated from animals and humans. aEPEC are indeed quite frequently associated with diarrhoea in young calves. Although calf aEPEC can belong to the O26:H11 and O80:H2 serotypes, most serotypes remain unidentified (Mainil and Fairbrother, 2014). The general purpose of this project is to identify the serotypes of aEPEC isolated from diarrheic calves and to compare them with calf and human Shiga toxin-producing E. coli (STEC) belonging to the same serotypes. The specific purpose of the study reported here was therefore to test 41 and 35 un-typed aEPEC and STEC for five non-conventional O serogroups (O123/186, O156, O177, O182, O183) recently identified in 5 calf aEPEC and STEC that previously tested negative, using two multiplex PCRs and to confirm the positive results with the uniplex PCRs. Twenty-three aEPEC (56%) tested positive with the multiplex and uniplex PCRs: 9 for the O123/186 serogroups (these two serogroups cannot be distinguished by PCR), 12 for the O177 and 2 for the O182 serogroups. In addition, the PCRs also detected 8 STEC (23%): 1 for the O123/186, 2 for the O156, 1 for the O177, 2 for the O182 and 2 for the O183 serogroups.  Besides the classical O26:H11 serotype, calf aEPEC belong to several non-conventional serogroups/-types, like O80:H2 and those identified in this study, though still other serogroups/-types remain to identify. The further steps are: (i) comparison of these calf aEPEC with calf and human STEC belonging to the same serogroups/-types; (ii) investigation to answer the following question: are these calf aEPEC true aEPEC, or STEC derivatives that have lost stx genes, or STEC precursors that could acquire stx genes in the future? (iii) identification of still other serogroups/-types amongst the remaining un-typed calf aEPEC. [less ▲]

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See detailComparative Study of Reduced Order Modeling Techniques Applied to Geometrically Nonlinear Structures
Delhez, Elise ULiege; Nyssen, Florence; Batailly, Alain et al

Poster (2019, June)

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See detailSi-Doped Carbon Xerogels for Li/Na-ion Batteries
Carabetta, Joseph ULiege; Job, Nathalie ULiege

Poster (2019, May 30)

The use of dopants such as silicon, tin, and, more recently, antimony in carbonaceous anodes is a promising area of research to increase the performance of lithium and sodium ion batteries [1-3]. The ... [more ▼]

The use of dopants such as silicon, tin, and, more recently, antimony in carbonaceous anodes is a promising area of research to increase the performance of lithium and sodium ion batteries [1-3]. The biggest obstacle to the progress of this technology is the stability of these inclusions in the carbon material during charging and discharging, most notably the volume change of the active material [4-8]. An electrode design was synthesized that consists of a carbon xerogel via a sol-gel process (CX), which acts as a support structure for a dopant, silicon nanoparticles (SiNPs), and provides electronic conductivity. Syntheses have been made using poly(sodium 4-styrenesulfonate) (PSS) as a coating or binder. These syntheses showed positive results on the cyclability of the CX/SiNPs composite. A 5-fold increase was observed in the number of charge/discharge cycles before the reversible capacity was less than 80% the initial capacity when compared with a composite with no coating and conventional binder. The gradual loss in capacity in the coated composite is still unknown, but may be due to the interplay between SEI formation and the volume expansion of the SiNPs. These problems are now being addressed by various techniques to improve the chemical and mechanical stability, and tailoring the microporosity and mesoporosity to reduce the irreversibly capacity loss and increase the accessibility to the dopant material. References: [1] W. Luo et al. Journal of Power Sources 304 (2016) 340–345 [2] B. Guo et al. Journal of Power Sources 177 (2008) 205–210 [3] RSC Advances, 2012, 2, 4311–431 [4] W.J. Zhang, J. Power Sources 196 (2011) 13–24 [5] H. Wu, Y. Cui, Nano Today 7 (2012) 414–429. [6] L.Y. Beaulieu, K.W. Eberman, R.L., et al. Electrochem. Solid-State Lett. 4 (2001) A137–A140. [7] J.H. Ryu, J.W. Kim, et al. Electrochem. Solid-State Lett. 7 (2004) A306–A309. [8] M.A. Rahman, G. Song, A.I. Bhatt, et al. Adv. Funct. Mater. 26 (2016) 647–678. [less ▲]

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See detailXPS and Raman study of spray-dried Na3V2(PO4)2F3/C as cathode material for sodium ion batteries
Eshraghi, Nicolas ULiege; Bodart, Jérôme ULiege; Mahmoud, Abdelfattah ULiege et al

Poster (2019, May 28)

Na3V2(PO4)2F3 (NVPF) has attracted much attention as cathode material for Na-ion batteries thanks to the inductive effects allowing for a high working potential combined with a high theoretical specific ... [more ▼]

Na3V2(PO4)2F3 (NVPF) has attracted much attention as cathode material for Na-ion batteries thanks to the inductive effects allowing for a high working potential combined with a high theoretical specific capacity due to the multiple oxidation states of vanadium [1-2]. One of the limitations of NVPF electrodes is their low intrinsic electronic conductivity; therefore, we have prepared composites of NVPF with conductive carbon sources to ensure higher electronic conductivity of the electrodes. NVPF and NVPF/carbon composite materials were prepared by spray-drying as in our previous work [2]. Spray drying is a cost-effective and up-scalable route to prepare homogeneous multi-component powders, thus making it a suitable method to incorporate carbon in the composite powder [4]. The influence of different carbon sources on structural and morphological properties of NVPF and NVPF/carbon composite was investigated by combining several characterization techniques (XRD, SEM and TEM). The chemical composition at the surface of the powders were studied using XPS. Raman spectroscopy was used to evaluate the quality in disordered carbon materials and its electronic conductivity [3] and compare the results with the results from EIS and cycling performance of different samples. References: [1] Shakoor et al., Chem. 22,2012, 20535. [2] Eshraghi et al., Electrochimica Acta, 228, 2017, 319. [3] Mahmoud et al., J Solid State Electrochem. 22, 2018,103. [4] Vertruyen et al., Materials 2018, 11, 1076. [less ▲]

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See detailWater footprint and regionalization: the case study of Walloon corn
Gerbinet, Saïcha ULiege; Van Stappen, Florence; Léonard, Angélique ULiege

Poster (2019, May 28)

Corn is an important cereal with a lot of applications in the feed and food industries (e.g. starch production). To evaluate properly the environmental impact of its applications, for example in the ... [more ▼]

Corn is an important cereal with a lot of applications in the feed and food industries (e.g. starch production). To evaluate properly the environmental impact of its applications, for example in the growing context of biobased products, a better understanding of the impact of its production is needed, using Life Cycle Analysis (LCA). The studied system is the production of corn in Wallonia (South of Belgium), whose the primary data are taken from Van Stappen et al (2018. Sensitive parameters in local agricultural life cycle assessments: the illustrative case of cereal production in Wallonia, Belgium. Int J Life Cycle Assess 23 2: 225–250). The functional unit is 1 hectare of corn crop in Wallonia. The LCI data are based on actual agricultural practices recorded in farms’ accounting data. The system has been modelled in GaBi 8 using GaBi datasets. The ILCD recommended method has been used. To have a better understanding of water depletion, some other methodologies have been tests for this specific impact categorie such as ReCiPe and the AWARE model. The part of water resources depletion using ILCD recommended method that is not due to the fertilizers (20 %) production is mostly related to the electricity used for maize drying and storage (70 %), especially associated with nuclear electricity (cooling needs). This is not the case if another method is used for assess the water depletion, if AWARE method is used, most of the impact is coming from fertilizers production and from mechanization (due to the use of on unspecified flow for water consumption), whereas, using ReCiPe, most of the impact is from fertilizers production only. A study of the water origin has been realized using AWARE and ILCD recommended method and underline the large variety of results. The share of nuclear electricity in water depletion is really high when using ILCD recommended method, therefore special attention has been put on this process.: we have compared the GaBi dataset with the Ecoinvent dataset. For the Ecoinvent dataset the calculation have been realized in GaBi but also in Simapro. This comparison is realized for the three method investigate there and underlines large differences between software. Therefore, this contribution allows to underline the difference between method for water depletion calculation but also the differences induced by regionalized or not regionalized datasets and also underline the problem of results that are dependant of the softawre. [less ▲]

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See detailDevelopment of Nanovectors for the Targeted Delivery in Anopheles Mosquitoes of Drugs against Plasmodium Parasites
Siden-Kiamos, Inga; Deligianni, Elena; Spanos, Lefteris et al

Poster (2019, May 28)

Detailed reference viewed: 17 (1 ULiège)
See detailUse of Ugi-three component reaction for the synthesis of poly(α-amino amide)s
Stiernet, Pierre ULiege; Lecomte, Philippe ULiege; De Winter, Julien et al

Poster (2019, May 27)

Multicomponent reactions (MCRs), in which three or more compounds react and form a product containing essentially all atoms of the starting reagents, have been thoroughly exploited in organic synthesis ... [more ▼]

Multicomponent reactions (MCRs), in which three or more compounds react and form a product containing essentially all atoms of the starting reagents, have been thoroughly exploited in organic synthesis for preparing complex molecules. However, their use in polymer science remained limited until recently. For example, Ugi-four component (Ugi-4CR) was used to synthesize α-amido amide containing polymers. Our research aims to explore the potential of a variant of the Ugi MCR, namely the Ugi-three component reaction (Ugi-3CR), in the field of polymer and to prepare macromolecules containing α-amino amide structure. Ugi-3CR [less ▲]

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See detailMechanistic and kinetic insight into the carbonatation reaction of diols to afford (a)cyclic carbonates: toward CO2-based monomers
Brege, Antoine ULiege; Méreau, Raphaël; Grignard, Bruno ULiege et al

Poster (2019, May 27)

The present research aims at investigating in details the reaction between carbon dioxide and a diol to afford cyclic and acyclic carbonates in moderate to good yields. Thanks to its chemical structure ... [more ▼]

The present research aims at investigating in details the reaction between carbon dioxide and a diol to afford cyclic and acyclic carbonates in moderate to good yields. Thanks to its chemical structure, CO2 has been identified as a promising reagent for the synthesis of organic carbonates as it is non-toxic, cheap and an abundant C1 renewable feedstock, and could potentially replace phosgene based carbonates produced industrially. These organic carbonates are key intermediates for the production of aliphatic polycarbonates, which have regained more and more attention over the past decades. Thus, developing tools for the synthesis of CO2-based carbonates as monomers is of high interest. Prior research has been focused on the epoxide/CO2 coupling to afford cyclic carbonates in good yields. Yet, this coupling suffers from limitations such as restricted substrates and exclusive synthesis of 5-membered cyclic carbonates. In order to extend the products availability through Carbon Dioxide Utilization, more recent research has been carried out with new substrates such as the use of diols. Although many different catalysts and reaction routes have already been investigated, efforts are still needed to identify cheaper and more efficient protocols for the selective synthesis of cyclic and acyclic carbonates from the coupling of CO2 with diols. In this context, the use of organic bases/alkylating agent dual system as promoters and low pressure and temperature conditions (P<1MPa, r.t) seem to be a good alternative to afford organic carbonates. The present work aims at providing, thanks to an in-situ ATR-IR spectroscopy monitoring, a detailed understanding of the synthesis of propylene carbonate from propylene glycol and CO2 promoted by DBU and the addition of alkyl halides. This analytical tool enabled to identify several reaction intermediates and to determine how the kinetic profiles, the reaction yields, and the selectivity of the reaction evolves with various parameters (pressure, temperature and nature of the base and alkyl halide). Thus, several experimental conditions have been tested as well as various alkyl halides in order to understand in details the effect on the selectivity and the efficiency of the reaction. Different substrates were also tested such as 1,x diols (2 ≤ x ≤ 4) and Isosorbide. The selectivity toward cyclic or biscarbonated compounds is discussed. Density Functional Theory (DFT) was also performed in this work to understand and validate the reaction pathways proposed via ATR-IR monitoring. Structures of transition states were optimized and comparisons between several reagents and/or paths were calculated, giving capital information about further enhancement of the CO2-diol conversion into carbonates. [less ▲]

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See detailEfficient moisture-sensitive shape-memory materials composed of supramolecular network of poly(ε-caprolactone) and poly(ethylene oxide)
Caprasse, Jérémie ULiege; Thomassin, Jean-Michel ULiege; Riva, Raphaël ULiege et al

Poster (2019, May 27)

Shape-memory polymers (SMPs) are remarkable stimuli-responsive materials able to switch from one stable macroscopic shape to another one, which can find application as smart medical devices. For this ... [more ▼]

Shape-memory polymers (SMPs) are remarkable stimuli-responsive materials able to switch from one stable macroscopic shape to another one, which can find application as smart medical devices. For this purpose, covalent crosslinked poly(ε-caprolactone) (PCL) is widely studied because it is biocompatible, degradable, exhibits efficient thermally triggered shape memory properties, i.e. high fixity of the temporary shape, high recovery of the permanent shape and has good mechanical properties. In this work, an hydrophilic component, i.e. poly(ethylene oxide), is introduced into PCL networks in order to impart an additional shape transition triggered by hydration of the material at constant temperature. The network of both materials is formed by reaction of the maleimide end-capped PCL stars with furan end-capped PEO stars. After melt-mixing and a post-curing of 48h, this material shows high crosslinking density as demonstrated by swelling behavior, good mechanical properties and excellent shape memory properties,. Moreover, moisture triggered shape transition is observed in addition to conventional thermal shape memory properties. [less ▲]

Detailed reference viewed: 16 (2 ULiège)
See detailSynthesis of new PLGA based grafted polymers for formation of bioactive nanoparticles
Toullec, Clément; Boury, Frank; Grignard, Bruno ULiege et al

Poster (2019, May 27)

The loss of bone tissues because of age, obesity, trauma or diseases can provoke a significant morbidity and an important socio-economical cost. During the last few decades, tissue engineering and ... [more ▼]

The loss of bone tissues because of age, obesity, trauma or diseases can provoke a significant morbidity and an important socio-economical cost. During the last few decades, tissue engineering and regenerative medicine have become promising strategies for rebuilding bones. The tissue engineering of bones has for objective the functional regeneration of bones through a synergetic combination of biomaterial scaffolds, cells and active biomolecules such as proteins, peptides or growth factors. The objective of our work was to synthesize a copolymer, curdlan-graft-PLGA, in supercritical CO2 without any organic solvent. This copolymer was then used for the formulation of nanoparticles that are intended to be loaded with bioactive molecules for bone regeneration. Starting with cyclic monomers, glycolide and lactide, poly-lactic-co-glycolic acid (PLGA) was obtained through ring-opening polymerization (ROP) in supercritical carbon dioxide (scCO2). Curdlan (1,3-β-glucan), a polysaccharide, was used as an initiator. Organic catalysers, including 1,8-diazabicyclo[5.4.0]undec-7-ene and thio-urea, were also used. The purity, composition and molecular mass of the curdlan-graft-PLGA copolymer were determined with liquid NMR. Nanoparticles were prepared through a phase separation method. The copolymer was dissolved in dimethyl isosorbide (DMI), then an anti-solvent, an aqueous solution of glycine and NaOH, was progressively added in large excess. The average nanoparticle size was determined by dynamic light scattering. The morphology of nanoparticles was studied with scanning and transmission electronic microscopy. Finally, the zeta potential was also measured. In this work, we used curdlan both as an initiator for the ROP and as a backbone for the copolymerization with PLGA. Thus, the resulting curdlan-graft-PLGA copolymer is composed of PLGA chains grafted on the curdlan backbone. scCO2 is considered as a “green” solvent because its critical pressure and temperature are relatively low, it is abundant, inert, nontoxic and non-flammable. Therefore, the ROP in scCO2 allows to obtain the curdlan-graft-PLGA copolymer in one step without any toxic solvent. Moreover, the synthesis parameters were optimised to diminish the amount of organocatalysts used. The rate of conversion of this process was determined to be of 98% and the molar mass of the PLGA grafts synthesised of 10 000g.mol-1. Nanoparticles were formed using this copolymer via a method of nanoprecipitation by phase separation. This method uses the difference in hydrophilicity between PLGA and curdlan. Curdlan is more hydrophilic than PLGA, therefore it will be preferentially oriented toward the aqueous phase on the surface of the nanoparticles while the PLGA will find itself in the core. This configuration was confirmed by modifying the quantity of curdlan in the copolymer which leads to a difference in the zeta potential of nanoparticles. The particles were observed to be spherical with a diameter of 300 nm in average and a polydispersity index of 0.2. [less ▲]

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See detailElement activation strategy for Additive Manufacturing, based on the element deletion algorithm
Laruelle, Cédric ULiege; Boman, Romain ULiege; Papeleux, Luc ULiege et al

Poster (2019, May 27)

With the rise of Additive Manufacturing (AM) technologies in the industry, it is becoming more and more crucial to have a good understanding of those processes. This leads to a high need for the ... [more ▼]

With the rise of Additive Manufacturing (AM) technologies in the industry, it is becoming more and more crucial to have a good understanding of those processes. This leads to a high need for the implementation of a model that can accurately simulate such a process. The difficulties of simulating AM can come from multiple sources. Firstly, from the nature of the process. Indeed, it requires a large deformation thermo-mechanical simulation. Secondly, the modeling of the material law is complex. Lastly, the geometry of the process imposes a very fine discretization (layers can be as small as a few μm). This creates models that are very computationally costly. Moreover, the process requires altering the geometry of the model during simulations to model the addition of matter, which is a computational challenge by itself. This poster presents the implementation of a three-dimensional thermal Finite Element Analysis (FEA) of AM in the fully implicit in-house Finite Element code “Metafor”. The main focus of the work is on mesh management techniques. The method to activate elements during a simulation is adapted from the element deletion algorithm (erosion method) implemented in Metafor in the scope of crack propagation. The final model is compared against literature results with a good agreement. [less ▲]

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See detailSupercritical CO2 foaming of PCL covalent networks : taking benefit from the thermo-reversible Diels-Alder cycloaddition
Houbben, Maxime ULiege; Malherbe, Cédric ULiege; Thomassin, Jean-Michel ULiege et al

Poster (2019, May 27)

Foams are versatile materials encountered in our daily life for a wide variety of uses such as cushioning, thermal and acoustic insulation or medical applications. The combination of the mixed properties ... [more ▼]

Foams are versatile materials encountered in our daily life for a wide variety of uses such as cushioning, thermal and acoustic insulation or medical applications. The combination of the mixed properties between a continuous matrix and gas cells and the diversity of pore structures represent a powerful tool for the design of new materials. Among the different polymer foam fabrication processes, the use of supercritical CO2 has been one of the most investigated in the past decade. Nevertheless, the design of crosslinked polymer foams with high foaming ratio still remains a challenge. Various crosslinking processes mainly based on heating, irradiation with the addition of an external agent have been applied after foaming but remain difficult to perform due to mass transfer issues of the crosslinking agent. When crosslinking occurs before foaming, it dramatically limits the material expansion. In order to overcome these drawbacks, the present work aims taking advantage of the thermoreversible Diels-Alder cycloaddition to elaborate foams of poly(ε-caprolactone) (PCL) covalent networks. Based on this reaction, we considered to induce cross-linking after the foam expansion by playing on the thermal equilibrium of the thermoreversible Diels-Alder cycloaddition. Therefore, low molar mass star-shaped PCL end-capped by furan or maleimide were impregnated with CO2 under supercritical conditions and then foamed under appropriate control of the pressure and temperature. Annealing about 2h at 40°C allows Diels-Alder adducts to be formed and a stable PCL network keeping at least 80% of the expanded volume is obtained. The resulting foam possesses a much higher volume expansion than a pre-crosslinked sample foamed in the same conditions, thanks to the low crosslinking ratio during foaming. These foams exhibit also improved thermal stability thanks to its chemical crosslinking as compared to non-crosslinked PCL foams. Interestingly, these foams possess shape memory properties due to the semi-crystallinity of the PCL. Thermal stability and shape memory properties were evaluated by dynamic mechanical analysis in both tensile and compression testing with controlled force mode, stress and temperature ramps. [less ▲]

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See detailNumerical investigation of critical states in superposed superconducting films
Burger, Loïc ULiege; Veshchunov, Ivan S.; Tamegai, Tsuyoshi et al

Poster (2019, May 23)

While offering enhanced or new functionalities, three-dimensional superconducting structures have a richer magnetic response than planar devices. A particular class of three-dimensional structures is ... [more ▼]

While offering enhanced or new functionalities, three-dimensional superconducting structures have a richer magnetic response than planar devices. A particular class of three-dimensional structures is obtained by stacking nanostructured superconducting layers, resulting in systems where the planar subcomponents are magnetically coupled with one another, thereby opening the possibilities of new magnetic flux penetration processes. In thin superconducting films, abrupt changes in the direction of shielding currents are manifested in the form of discontinuity lines (d-lines), which vortices cannot cross. For instance, in a square film, d-lines appear along the diagonals, while in a rectangular film, they follow a double Y shape. Such structures can be observed through magneto-optical imaging (MOI). When a rectangular superconducting thin strip is superimposed to a superconducting square film, the resulting d-lines do not correspond to a simple superposition of the d-lines of each individual film, additional d-lines appear [1]. In this work, we investigate the d-lines of bi-layered superconducting thin films numerically. We use a finite element H-phi formulation, where shell-transformations [2] are used in the far-field region outside the films, so that boundary conditions are applied at an infinite distance from the conductors. We show the key role of the magnetic field dependence of the critical current density jc(B), which is modelled with Kim’s law jc(B) = jc0/(1+|B|/ B0), in the apparition of the additional d-lines. We demonstrate the modification in the shape of the d-lines with respect to the magnitude of the applied magnetic field, while it is increased and then decreased back to the remanent state. The influence of the spacing between both films, B0, jc0 on the geometrical characteristics of the additional d-lines is also investigated. [less ▲]

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See detailSynthesis of supramolecular networks of poly(e-caprolactone) and poly(ethylene oxide) as moisture sensitive shape-memory materials
Caprasse, Jérémie ULiege; Thomassin, Jean-Michel ULiege; Riva, Raphaël ULiege et al

Poster (2019, May 23)

Shape-memory polymers (SMPs) are remarkable stimuli-responsive materials able to switch from one stable macroscopic shape to another one, which can find application as smart medical devices. For this ... [more ▼]

Shape-memory polymers (SMPs) are remarkable stimuli-responsive materials able to switch from one stable macroscopic shape to another one, which can find application as smart medical devices. For this purpose, the covalent crosslinked poly(ε-caprolactone) (PCL) is widely studied because it is biocompatible, degradable, exhibit efficient thermally triggered shape memory properties, i.e. exhibit high fixity of the temporary shape and high recovery of the permanent shape and has good mechanical properties. In this work, an hydrophilic component, i.e. poly(ethylene oxide), is introduced into PCL networks in order to impart an additional shape transition triggered by hydration of the material at constant temperature. The network of both materials is formed by reaction of the maleimide end-capped PCL stars with and furan end-capped PEO stars. This material exhibits high crosslinking density and excellent shape memory properties, after a post-curing of 48h. Moisture triggered shape transition is observed in addition to conventional thermal shape memory properties. [less ▲]

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See detailLa lexicographie bilingue français-néerlandais aux XVIe et XVIIe siècles : étude de métalexicographie historique
Zimont, Elizaveta ULiege

Poster (2019, May 23)

Le projet de recherche a pour objectif de fournir une analyse métalexicographique, comparative et en moyenne durée, d'un corpus exhaustif d’ouvrages lexicographiques bilingues français-néerlandais et ... [more ▼]

Le projet de recherche a pour objectif de fournir une analyse métalexicographique, comparative et en moyenne durée, d'un corpus exhaustif d’ouvrages lexicographiques bilingues français-néerlandais et néerlandais-français imprimés aux XVIe et XVIIe siècles (1527 –– ca 1700). Cette étude innovatrice combine l’approche linguistique (métalexicographique) à la méthodologie du repérage informationnel ainsi qu’à l’examen historiographique de la corrélation entre le contenu et la forme de l’information dictionnairique, d’un côté, et le contexte culturel et socio-économique, de l’autre. [less ▲]

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See detailQu’advient-il de l’idéologie postcoloniale dans les études littéraires et de linguistique anglaise au 21ème siècle ?
Gerday, Laura ULiege

Poster (2019, May 23)

L’aurore naissante du 21ème siècle semble avoir baigné les champs des études littéraires et de linguistique anglaise de ses lueurs nouvelles. D’une part, l’ouvrage de Jennifer Jenkins paru en l’an 2000 ... [more ▼]

L’aurore naissante du 21ème siècle semble avoir baigné les champs des études littéraires et de linguistique anglaise de ses lueurs nouvelles. D’une part, l’ouvrage de Jennifer Jenkins paru en l’an 2000, The Phonology of English as an International Language, a généré quantité de recherches innovantes visant à caractériser l’anglais employé par des locuteurs non-natifs en situation de communication dite internationale – à savoir l’ « English as a Lingua Franca » (ELF). D’autre part, l’article incisif et ambitieux « Conjectures on World Literature » de Franco Moretti, également publié en 2000, a été une amorce des débats actuellement menés autour de la résurgence du concept goethéen de Weltliteratur en critique et théorie littéraires. Une impulsion commune aux « ELF » et « world literature » studies est cette volonté de répondre aux enjeux sans précédent de ce que d’aucuns nomment la mondialisation, en particulier la plus vaste distribution et les contextes d’usage modernes de la langue anglaise et des productions littéraires. S’est ainsi formé un paradigme théorique globalisant en linguistique et en littérature, un paradigme qui a dû composer avec l’idéologie postcoloniale alors fermement ancrée dans ces disciplines connexes. Le présent poster propose d’exposer de manière schématique les répercussions de l’avènement de ce « global paradigm » sur les écoles de pensée postcoloniale. Il détaillera l’examen de deux notions-clés à propos desquelles linguistes et chercheurs en littérature de chaque orientation – globalisante et postcoloniale – paraissent se diviser. [less ▲]

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See detailDevelopment of chromium for mid-flux region PFCs for DEMO divertor
Khvan, Tymofii ULiege; Terentyev, Dmitry; You, Jeong-Ha et al

Poster (2019, May 23)

Continuous efforts in the design of plasma-facing components (PFC) for DEMO divertor unravel new challenges to be met by the in-vessel materials. Embrittlement induced by 14 MeV neutrons in tungsten, main ... [more ▼]

Continuous efforts in the design of plasma-facing components (PFC) for DEMO divertor unravel new challenges to be met by the in-vessel materials. Embrittlement induced by 14 MeV neutrons in tungsten, main candidate for the first wall material, is one of the hottest issues to be addressed in the design of PFCs with a reliable structural integrity. For designing mid heat flux PFCs, chromium (Cr) is currently considered as material for the main body connected to tungsten armour tile and cooling pipe. Cr has the superior toughness property in the low temperature range where the commercial tungsten products are brittle. Cr is an excellent material to reduce the oxidation in case of loss-of-vacuum accident [1], as well as it does not experience such harsh transmutation as W does producing Re and Os yielding to disadvantageous precipitation and embrittlement. The advantages of Cr may help substantiation of water coolant design and usage of ITER experience for licensing of PFC components. However, the mechanical properties of Cr are extremely sensitive to purity. Because of that commercially produced Cr grade (Plansee) in non-irradiated state exhibits rather high ductile to brittle transition temperature (DBTT) ~150-250°C [2]. Here, we employ vacuum arc melting (VAC) equipment for fabrication of Cr and Cr-W alloy suitable for PFCs, which represents new promising alternative route with high upscale potential. VAM fabrication improves Cr quality by avoiding the introduction of interstitial impurities, while the produced grades can be further mechanically treated to design dedicated microstructure and enhance the yield strength. The produced heats of pure Cr and Cr-10W are investigated by means of chemical and microstructural analysis as well as mechanical testing and compared with the Plansee Cr. The VAM-produced pure Cr shows DBTT below room temperature proving the principal advantage of this fabrication route. [less ▲]

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See detailColorectal Cancer : Biomarkers and Effect Size
Di Giovanni, Nicolas ULiege; Meuwis, Marie-Alice ULiege; Louis, Edouard ULiege et al

Poster (2019, May 21)

Colorectal cancer kills more than 700.000 persons each year worldwide. Nevertheless, its diagnosis is still largely based on invasive tissue sampling and gaps remain in the understanding of its ... [more ▼]

Colorectal cancer kills more than 700.000 persons each year worldwide. Nevertheless, its diagnosis is still largely based on invasive tissue sampling and gaps remain in the understanding of its pathogenesis, with complex combinations between lifestyle, genetics, epigenetics, chronic inflammation (IBD) and microbiota. We analyzed serum samples from patients affected by colorectal cancer (CRC, n = 18) and by colorectal cancer in remission (R-CRC, n = 17), and samples from healthy patients matched for biases (HC, n = 19 and R-HC, n = 17). The aim was to find candidate biomarkers able to diagnose the active state of the disease as well as to compare the concentration levels of the molecules of interest with the remission state to better understand the biolocal processes beneath the observed clinical and metabolic symptoms. To do so, an optimized and validated (NIST SRM 1950) comprehensive GC×GC-(HR)TOFMS method we developed was used. It includes an in-house QC system, data processing based on multiple statistical techniques and identification using full mass spectrum, linear retention indices and accurate mass provided by state-of-the-art high-resolution (HR) time-of-flight mass spectrometry. Because the experimental design prevented a direct comparison between the active and remission samples, which were not directly matched for biases, we used a measure called effect size that has the advantage to not only focus on statistical significance but on effect (here signal variation) magnitude. We will discuss the interest and application of effect size in metabolomics and we will present the highlighted candidate biomarkers in terms of discrimination potential. [less ▲]

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See detailEndophytic entomopathogenic fungi and host plant interactions: impact on phytovirus transmission by insect vector
Fingu Mabola, Junior ULiege; Francis, Frédéric ULiege

Poster (2019, May 21)

Entomopathogenic fungi (EPF) are biological agents used to control crop pests. They infect their host insects transcutaneously, synthesize toxic secondary metabolites, multiply and colonize their host ... [more ▼]

Entomopathogenic fungi (EPF) are biological agents used to control crop pests. They infect their host insects transcutaneously, synthesize toxic secondary metabolites, multiply and colonize their host tissues leading to death. Currently, the mode of action by contact is the most widespread, but recent studies highlighted the successful way of inoculating endophytic strains in plants for systemic action. Therefore, endophytic EPF complete their life cycle in host plants tissues without symptom appearance. They interact then with plants pests and phytopathogenic agents. Our goal was to determine whether the presence of endophytic EPF in host plant tissues influenced the vector insect behavior with an impact on plant virus transmission. Previously, we have shown that the inoculation of two commercial strains of EPFs (Beauveria bassiana GHA from Botanigard® and Metarhizium acridum ARSEF 7486 from Green Muscle®) on tobacco (Nicotiana tabacum L.) have a negative influence on the Myzus persicae Sulzer life history. Here, we were looked at the transmission aspect of the Potato leaf roll virus (PLRV) on tobacco by M. pesicae. After a qualitative ELISA test on plants infested with virus-carrying insects, we found that a trend is emerging on inoculated B. bassiana plants with low PLRV transmission rate relative to the control. Interactions between plant – aphid – virus and entomopathogenic fungi are discussed in terms of optimal stragtegies to promote broad biological control and sustainable crop production. [less ▲]

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See detailQuelle place pour la santé dans la qualité de la vie déclarée à 16 ans ? Comparaison à 37 ans de distance en région liégeoise.
Leclercq, Dieudonné ULiege; Sauvage, Chloé; Pétré, Benoît ULiege

Poster (2019, May 20)

En 1982, une recherche européenne centrée sur l’économie [1] s’est déroulée dans 4 régions : Lyon, Liège, Berlin et Manchester. Dans ce cadre, 300 enfants de 12 ans et 273 ados de la région liégeoise ont ... [more ▼]

En 1982, une recherche européenne centrée sur l’économie [1] s’est déroulée dans 4 régions : Lyon, Liège, Berlin et Manchester. Dans ce cadre, 300 enfants de 12 ans et 273 ados de la région liégeoise ont répondu à la question « Parmi ces 20 éléments, choisissez les 8 qui représentent le mieux la qualité de la vie ». La santé est apparue comme l’élément le plus choisi aux deux âges et dans les 4 régions. En 2019, 208 ados de la région liégeoise ont répondu au même questionnaire. Les 20 items portaient sur 10 thèmes, chacun représenté par un item qualitatif (ex : sécurité routière) et un item quantitatif (ex : réseau routier). Le poster présente les principaux réultats, notamment la comparaison entre 1982 et 2019. [less ▲]

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See detailBien-être relationnel au doctorat & Style d'encadrement du promoteur
Christophe, Virginie ULiege

Poster (2019, May 20)

En Flandre (Belgique), il fut récemment démontré que 40,8% des doctorants vivent un stress constant et que 30,3% sont dans un état dépressif. Parmi les déterminants du mal-être au doctorat, l’on peut ... [more ▼]

En Flandre (Belgique), il fut récemment démontré que 40,8% des doctorants vivent un stress constant et que 30,3% sont dans un état dépressif. Parmi les déterminants du mal-être au doctorat, l’on peut retrouver la relation au promoteur. L’objectif de la présente étude fut d'évaluer deux facteurs pouvant impacter la qualité de cette relation, soit, l'impact du type d'encadrant et la satisfaction de la fréquence de rencontre avec le promoteur. [less ▲]

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See detailPHYSICO-CHEMISTRY, PROTEOMICS AND IN VIVO COMPARATIVE TESTS TO REVEAL VARIABILITY IN MULTISTRAIN PROBIOTIC FORMULATIONS
Razafindralambo, Hary ULiege; Correani, Virginia; Mattei, Benedetta et al

Poster (2019, May 18)

VSL#3 powder formulations originated from two production sites (USA- and ITALY-made products) were subjected to a physicochemical characterization based on thermal and colloidal properties [1], proteomics ... [more ▼]

VSL#3 powder formulations originated from two production sites (USA- and ITALY-made products) were subjected to a physicochemical characterization based on thermal and colloidal properties [1], proteomics analyses, and in vivointestinal permeability tests on animal models. Thermogravimetry-Differential Scanning Calorimetry (TGA-DSC) analyses provided powder sample profiles in mass and internal energy changes under temperature scan, and thermophysical data in terms of material decomposition and transition phases. Sample particle sizes, size distributions, and charges at the dispersed state informed on their capacity to remain stable in aqueous suspension. Table 1 compares physicochemical data generated from USA- and ITALY-made formulations obtained with different lots (lots DM538 and 10151198 analyzed after 0 and 3 months for USA vs.lots 512058 and 3302E10 analyzed after 0 and 3 months for ITALY). Even though both formulations were qualitatively similar in thermal and colloidal profiles, significant differences were quantitatively observed in terms of maximum decomposition temperature Tmax (p< 0.05), and transition phase temperature Tm (p < 0.01), as illustrated in Figure 1. Further comparative analyses by proteomics showed 99 proteins decreased abundances and 38 increased ones in ITALY-made batch (lot 512058) compared to the US-made one (lot DM538), and revealed differences in protein identities and origins. In vivo intestinal permeability tests with old mice confirmed such significant differences between US-made lot DM538 and IT-made lot 512058. In conclusion, the thermal scan data and shotgun proteomic comparisons demonstrate significant physicochemical and chemical variability between multistrain probiotic VSL#3 formulations from two manufacturer countries. Such differences have an impact on the intestinal permeability in vivo. [1] Razafindralambo, H. et al. (2019). Physico-chemical Approach for Characterizing Probiotics at the Solid and Dispersed States. Food Research International, 2019, vol.116-897-904 [less ▲]

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See detailThe oncogenic transcription factor EWS-FLI1 drives mRNA instability in Ewing sarcoma
Galvan, Bartimée ULiege

Poster (2019, May 17)

In most cases, Ewing sarcoma arises from a chromosomal translocation between the genes encoding a RNA-binding protein from the FET family (EWS) and a transcription factor from the ETS-superfamily (FLI1 ... [more ▼]

In most cases, Ewing sarcoma arises from a chromosomal translocation between the genes encoding a RNA-binding protein from the FET family (EWS) and a transcription factor from the ETS-superfamily (FLI1). Because the DNA-binding domain of FLI1 replaces the RNA-binding of EWS and is associated with a transactivation domain, the fusion protein EWS-FLI1 has early been viewed as an aberrant transcription factor. However, many evidences from litterature and our lab are challenging this view and led us to investigate a potential role in mRNA degradation for this oncoprotein. [less ▲]

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See detailSplit-band SAR Interferometry For Vessel Tracking: Application On Sentinel-1 Data
Kirkove, Murielle ULiege; De Rauw, Dominique ULiege; Orban, Anne ULiege

Poster (2019, May 15)

Most recent Synthetic Aperture Radar (SAR) sensors use wide band signals to achieve metric range resolution. One can take advantage of this wide band to split a single acquisition into sub-bands and ... [more ▼]

Most recent Synthetic Aperture Radar (SAR) sensors use wide band signals to achieve metric range resolution. One can take advantage of this wide band to split a single acquisition into sub-bands and generate several lower-resolution images, centered on slightly different frequencies, performing so a SAR spectral analysis. One application of this process is the vessel detection based on spectral coherence analysis. We present a processing technique of vessel detection using SAR data, combining spectral coherence processing and Constant False Alarm Rate (CFAR) algorithm. The control of open seas areas or marine protected areas (MPAs) is usually performed based on the Automated Identification System (AIS) embarked within most of the vessels. The proposed technique handles a comparison with AIS data allowing to determine the ratio of non-cooperative vessels (or not equipped with AIS) within an area. We performed experiments on SAR data acquired on the Libyan Sea and we compared the results with the ones obtained by the SNAP “Ocean feature” tool, commonly used by the Remote Sensing community. [less ▲]

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See detailL'analyse prosodique: outil d'objectivation de l'efficacité thérapeutique dans le cadre de la féminisation vocale?
Blanckaert, Ellen ULiege; Mertens, Piet; Pillot-Loiseau, Claire et al

Poster (2019, May 15)

Objectifs Bien que l’intonation constitue une variable pertinente pour la perception de la féminité vocale (Hancock et al., 2014 ; Hillenbrand et al., 2009) force est d’admettre que cette composante ... [more ▼]

Objectifs Bien que l’intonation constitue une variable pertinente pour la perception de la féminité vocale (Hancock et al., 2014 ; Hillenbrand et al., 2009) force est d’admettre que cette composante prosodique est peu voire non abordée de manière objective lors de l’évaluation de l’efficacité thérapeutique. En effet, qu’il s’agisse du bilan vocal initial, d’évolution ou de fin de prise en charge, l’évaluation de la prosodie constitue un parent pauvre dont l’abord perceptif s’avère subjectif et non étayé. Notre objectif est, par conséquent, de recourir à un outil d’analyse automatique de la prosodie, sur base d’un modèle perceptif, et de juger de la pertinence du profil prosodique ainsi obtenu pour objectiver l’efficacité thérapeutique d’une prise en charge en féminisation vocale. Matériel et méthode Notre étude de cas porte sur une femme transgenre dont la prosodie est régulièrement évaluée au fil de sa prise en charge pour féminisation vocale. Pour ce faire, nous recourons à des tâches de lecture, langage semi-spontané et spontané et les analysons à l’aide de Praat (Boersma et Weenink, 2018) et Prosogram (Mertens, 2004) afin d’élaborer les profils prosodiques correspondants. Nous procédons ensuite à la comparaison des profils obtenus au fil de la rééducation ainsi que pré et post prise en charge. Résultats et discussion L’étude étant en cours, nous gageons que les données stylisées montreront des différences significatives entre le début, le décours et la fin de la prise en charge, à savoir : réduction du pourcentage de syllabes statiques, majoration de la trajectoire totale des variations intra- et inter-syllabiques, réduction de la proportion de phonation et allongement de la durée des noyaux vocaliques. Notre discussion portera sur la plus-value qu’apportent ces variables dans le cadre du bilan vocal (Dejonckere et al., 2001 ; Morsomme et Estienne, 2006). Conclusion L’intérêt de notre démarche est d’adjoindre simultanément au bilan vocal une dimension perceptive et une analyse objective de la prosodie. Le profil prosodique ainsi obtenu pourrait à terme contribuer à l’évaluation de l’efficacité thérapeutique de même qu’à la structuration de la prise en charge des personnes en réassignation de genre. L’analyse relevant d’une procédure automatique, cette démarche serait de surcroît aisément implémentable en clinique journalière. Cependant, dans la mesure où nous nous attendons à d’importantes variations inter-individuelles, nos résultats se devront d’être éprouvés auprès d’une plus vaste population. Références bibliographiques BOERSMA, P., & WEENINK, D. Praat : Doing phonetics by computer, version 6.0.43 [Computer program]. En ligne : http://www.praat.org ; 2018. DEJONCKERE, PH., BRADLEY, P., CLEMENTE P, CORNUT, G., CREVIER-BUCHMAN, L., FRIEDRICH, G., VAN DE HEYNING, P., REMACLE, M., & WOISARD, V. A basic protocol for functional assessment of voice pathology, especially for investigating the efficacy of (phonosurgical) treatments and evaluating new assessment techniques. Guideline elaborated by the Committee on Phoniatrics of the European Laryngological Society (ELS). European archives of oto-rhino-laryngology, 258, 2001, 77-82. HANCOCK, A., COLTON, L., & DOUGLAS, F., Intonation and gender perception : Applications for transgender speakers. Journal of Voice, Vol. 28, 2014, 203-209. HILLENBRAND, J.M., & CLARK, M.J., The role of F0 and formant frequencies in distinguishing the voices of men and women. Attention, Perception & Psychophysics, Vol. 71, 2009, 1150-1166. MERTENS, P. Un outil pour la transcription de la prosodie dans les corpus oraux. Traitement automatique des langues, Vol. 45/2, 2004, 109-130. MORSOMME, D., & ESTIENNE, F., Le bilan de voix. In F., Estienne, Les bilans de langage et de voix, Masson, 2006. [less ▲]

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See detailIs an expert-based model able to map erosion in agricultural catchments?
Cantreul, Vincent ULiege; Bielders, Charles; Swerts, Gilles ULiege et al

Poster (2019, May 15)

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See detailUnderstanding identity and its associated factors in cancer survivorship: A scoping review
Tilkin, Caroline ULiege; Vander Haegen, Marie ULiege; Etienne, Anne-Marie ULiege et al

Poster (2019, May 14)

Purpose. According to recent studies, the “survivor identity” is potentially a key factor for the psychological well-being of cancer survivors. But what exactly lay behind this concept remains unclear ... [more ▼]

Purpose. According to recent studies, the “survivor identity” is potentially a key factor for the psychological well-being of cancer survivors. But what exactly lay behind this concept remains unclear. The current review aimed to identify existing conceptualizations of the identity and its associated factors in adult cancer survivors. Methods. A scoping review was conducted following PRISMA-ScR guidelines. Three core databases (MEDLINE/Ovid, PsycINFO/Ovid and Scopus) were searched. Relevant studies from January 1985* to July 2018 were screened through a multi-step process guided by two independent reviewers. Results. Fifty-one articles were preliminary included for data extraction: 43% were quantitative studies, 47% were qualitative studies and 10% were mixed-methods design studies. Only 30% of the studies were related to the identification to the survivor’s identity. About 70% of the studies concerned other conceptualizations such as global self-concept (28%) or body image (23%). Quality of life was the most frequently associated factor (more than 26% of the studies). Conclusions. Several clinical (e.g. self-image, quality of life) but also psychosocial (e.g. socialization) factors related to the identity were found. Our results highlighted that identity in cancer survivorship is a complex issue where the survivor identity remains solely one piece of the puzzle. [less ▲]

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See detailUsing immersive 360° videos to asses sub-clinical forms of paranoia in the general population
Della Libera, Clara ULiege; Quertemont, Etienne ULiege; Laroi, Frank ULiege

Poster (2019, May 14)

For around fifteen years, virtual reality has been used as a new tool for studying paranoia. However, the use of virtual reality is expensive and requires the modelling of avatars that remain far from ... [more ▼]

For around fifteen years, virtual reality has been used as a new tool for studying paranoia. However, the use of virtual reality is expensive and requires the modelling of avatars that remain far from realistic in terms of facial and bodily expressions. As an alternative, 360-degree videos allow the creation of immersive environments to be more accessible and much more human-like. The aim of the present study was to validate a set of 360-degree videos as tools to identify sub-clinical forms of paranoia in the general population. Three videos representing daily scenarios (with four to fifteen actors) were created in a bar, a lift and a library. One hundred and seventy participants were assessed in terms of their general tendency towards paranoia (trait paranoia) before they viewed one video (using an Oculus Go headset). Finally, participants completed the State Paranoia Scale and the Sense of Presence Inventory. For both the lift and the library videos: an adequate sense of presence was found, and significant correlations between trait paranoia and state paranoia indicated good convergent and divergent validity. The present study suggests that the use of 360° videos is a promising tool to study forms of paranoia in the general population. [less ▲]

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See detailImproving Theory of Mind in Down syndrome ? An exploratory study
Comblain, Annick ULiege; Schmetz, Coraline

Poster (2019, May 14)

Background To communicate efficiently, it is important to understand the interlocutor’s perspective as well as the interlocutor’s feelings and emotions in a specific situation. These abilities are known ... [more ▼]

Background To communicate efficiently, it is important to understand the interlocutor’s perspective as well as the interlocutor’s feelings and emotions in a specific situation. These abilities are known to be impaired in DS children. It therefore makes sense to investigate the Theory of mind (ToM) development in this population. In our study, we explore the possibility of improving Down syndrome participants’ ToM abilities; these skills being important for understanding the subtleties of an interpersonal communication situation. Method DS subjects and typically developing children matched for non-verbal mental age were assessed. before and after a 10-weeks ToM multimodal training session. The pre- and post-test tasks came from the French adaptation of the ToM Inventory. Results At the end of the 10-weeks training, both trained group perform significantly better on ToM tasks that the untrained groups. Moreover, both trained show higher performances on pot-test than on pre-test whereas untrained groups performances remain stable. The DS trained group tend to perform better after the training session than the untrained typically developing children. Conclusion Results of our exploratory study are encouraging as they suggest that with a specific training DS children can improve their ToM abilities. [less ▲]

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See detailVirtual reality: A tool in the treatment of anxiety in stereotaxic radiotherapy?
Gamin, Nicolas ULiege; JANSEN, Nicolas ULiege; COUCKE, Philippe ULiege et al

Poster (2019, May 14)

Stereotaxic radiotherapy (SR) is an effective treatment for many types ofcancer but seems to cause anxiety. The purpose of this study is to determine whether experiencing the medical procedure by using ... [more ▼]

Stereotaxic radiotherapy (SR) is an effective treatment for many types ofcancer but seems to cause anxiety. The purpose of this study is to determine whether experiencing the medical procedure by using immersive virtual video can reduce preoperative anxiety. The experimental group (n=10) received information about the intervention and was exposed three times to the procedure before the SR. Two immersions took place in the days precedingthe intervention and the third took place just before the SR. The control group (n=10) only received information about the intervention. The STAI Y-A scale was used to measure state anxiety before and after each virtual immersion in the experimental group and just before and after the SR in both groups. We observed a similar decrease in anxiety across groups, which did not differ between them. Despite this result, it is important to point out that the experimental group reported a significant decrease in anxiety after the two immersions of day 1. The third immersion was not accompanied by a decrease of it. In conclusion, virtual reality seems useful in the treatment of preoperative anxiety, but its use is not enough to neutralize patient’s anxiety when approaching treatment [less ▲]

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See detailThe explicit use of PRISMA and its effect on the reporting completeness of meta-analyses in the field of behavioral and social sciences
Leclercq, Victoria ULiege; Beaudart, Charlotte ULiege; Ajamieh, Sara ULiege et al

Poster (2019, May 14)

Objectives: To investigate the effect of the explicit use of PRISMA, a statement designed to help authors to report meta-analyses (MAs), on the reporting quality of MAs in behavioral and social sciences ... [more ▼]

Objectives: To investigate the effect of the explicit use of PRISMA, a statement designed to help authors to report meta-analyses (MAs), on the reporting quality of MAs in behavioral and social sciences. Methods: We evaluated a random sample of 207 MAs indexed in PsycINFO in 2016; 100 explicitly used PRISMA and 107 did not. Two authors independently checked the 27 PRISMA items and extracted factors that could potentially be associated with reporting quality. Results: From our 207 MAs, perfect adherence to PRISMA was found in less than 4%, of which 87% explicitly used PRISMA. The following items were significantly more frequently encountered in MAs that explicitly used PRISMA: structured summary, protocol and registration, information sources, search strategy, study characteristics, results of individual studies, funding, study selection, risk of bias in individual study and bias across studies. The journals’ impact factors, the endorsement of PRISMA by the journal, the number of authors, the country of the first author, the open access of the article and the design of the studies were significantly and positively associated with the explicit PRISMA use. Conclusions: Even if far from optimal, the explicit use of PRISMA has a positive influence on the reporting completeness of MAs. [less ▲]

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See detailThe methodological quality of meta-analyses in behavioral and social sciences: leads for enhancements according to AMSTAR 2
Leclercq, Victoria ULiege; Beaudart, Charlotte ULiege; Ajamieh, Sara ULiege et al

Poster (2019, May 14)

Objectives: To investigate the methodological quality in meta-analyses (MAs) published in behavioral and social sciences. Methods: We evaluated a random sample of 207 MAs indexed in PsycINFO database in ... [more ▼]

Objectives: To investigate the methodological quality in meta-analyses (MAs) published in behavioral and social sciences. Methods: We evaluated a random sample of 207 MAs indexed in PsycINFO database in 2016. Two authors independently extracted methodologic characteristics of all MAs with the 16 items of AMSTAR2 (A MeaSurement Tool to Assess systematic Reviews 2). AMSTAR2 allows to assess the methodological quality of MAs that classifies them in 4 categories: critically low, low, moderate and high. Results: From the 207 MAs, according to AMSTAR2 criteria, 95% of MAs were rated as critically low. Statistical methods were appropriate and publication bias well evaluated in respectively 87% and 70% of the MAs. However, much improvement is needed in data collection and analysis: Publication of the research protocol (in 11% of MAs), comprehensive literature search strategy (44%), assessment (37%) and interpretation (29%) of risk of bias in individual included studies and presentation of excluded studies (11%). Conclusions: The methodological quality of MAs of our sample was critically low, according to AMSTAR2 criteria. Some efforts could improve tremendously the methodological quality of behavioral and social sciences MAs and thus gain in robustness and reliability. [less ▲]

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See detailThe impact of age on the temporal compression of daily-life events in episodic memory
Folville, Adrien ULiege; Jeunehomme, Olivier ULiege; Bastin, Christine ULiege et al

Poster (2019, May 14)

Recent evidence suggests that the dynamic flow of information that constitutes daily-life events is remembered as moments of prior experience separated by temporal gaps. To date, however, how aging ... [more ▼]

Recent evidence suggests that the dynamic flow of information that constitutes daily-life events is remembered as moments of prior experience separated by temporal gaps. To date, however, how aging impacts this process of compression of past experience in episodic memory has received little attention. To examine this question, young and older adults incidentally engaged in daily-life activities while wearing a camera. Subsequently, participants were cued with pictures taken by the wearable camera and were asked to mentally relive corresponding events in as much detail as possible. Results revealed that rates of temporal compression of events when remembering were similar in young and older adults. In both groups, these rates of compression were higher when remembering goal-directed actions compared to spatial displacements. Furthermore, the amount of detail within recalled moments did not differ between age-groups. Taken together, these results support the view that episodic memories represent the unfolding of events as compressed short-time slices of past experience. Our findings also suggest that these mechanisms of compression remain stable with increasing age which highlights the importance of using ecological approaches that capture the complexity of real-life events to examine age-related changes in episodic memory. [less ▲]

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See detailImpact of personality and media on terrorism perception
De Cuyper, Marine ULiege; Delhalle, Marine; Blavier, Adelaïde ULiege

Poster (2019, May 14)

Research showed that terrorism perception is influenced by the media. In this context, this study aimed to study how personality influences terrorism perception through qualitative and quantitative ... [more ▼]

Research showed that terrorism perception is influenced by the media. In this context, this study aimed to study how personality influences terrorism perception through qualitative and quantitative methods. Participants (n=90) answered an online questionnaire that measured danger perception of terrorist events, the media influence as well as personality (BFI-Fr). Afterwards, a semi-directive interview was realized with a sample of the online questionnaire participants (n=30) in order to give substance to the previous observations. Results suggested that some personality dimensions – agreeability and neroticism – are linked to high level of terrorism perception in terms of threat perception, worrying, avoidance and relation to the media. Furthermore, the media as well as personal characteristics – age, gender and profession – influence terrorism perception. [less ▲]

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See detailA replication study of the relationships between depressive symptoms, behavioral activation and avoidance depending on gender
Krings, Audrey ULiege; Wagener, Aurélie ULiege; Blairy, Sylvie ULiege

Poster (2019, May 14)

Behavioral activation is a well-established empirical treatment of depression focusing on two psychological processes that are activation and avoidance. Little is known about the relations between ... [more ▼]

Behavioral activation is a well-established empirical treatment of depression focusing on two psychological processes that are activation and avoidance. Little is known about the relations between depressive symptoms and these two psychological processes. Then, this study investigates the predictive value of behavioral activation and avoidance on depressive symptoms. Since depression seems to be characterized by gender differences, this study investigates these relations depending on gender. Furthermore, gender differences in symptoms profiles are assessed. These two aims tend to replicate results from the study of Wagener, Baeyens & Blairy (2016). Three hundreds and sixteen adults completed self-report scales centered on depressive symptoms (BDI-II) and behavioral activation and avoidance (BADS-SF). As in the initial study, our results show (1) a significant difference in symptomatology depending on gender for sadness and loss of interest in sex, (2) positive predictive values of behavioral avoidance on almost all depressive symptoms in both gender except for increase of sleep, (3) negative predictive values of behavioral activation on almost all depressive symptoms in both gender except for decrease of sleep and loss of interest in sex. The strengths of some of these relationships are different in gender in both study, but no consistent results were observed. Results support the notion that (1) depression is characterized by symptoms differences in function of gender and (2) behavioral activation and avoidance are two psychological processes to target in psychotherapy of depression. [less ▲]

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See detailConcurrent learning of explicit and implicit sequences
Marinelli, Vincent ULiege; Geurten, Marie ULiege; Meulemans, Thierry ULiege

Poster (2019, May 14)

This research focused on the efficiency of implicit sequence learning when an interfering sequence was presented in the same series of trials, with regards to the nature of the secondary sequence learning ... [more ▼]

This research focused on the efficiency of implicit sequence learning when an interfering sequence was presented in the same series of trials, with regards to the nature of the secondary sequence learning. In one condition, the interfering sequence was also learned implicitely. In another condition, the interfering sequence was described to the participant beforehand and trained. Results show that implicit learning is effective when an interfering secondary explicit sequence is presented. Although we could not clearly demonstrate an effective implicit learning in the implicit interference condition, there was no significant difference between the two conditions. These result indicate that the differential attentional requirements of the secondary sequence do not seem to play a role in the implicit learning of a previous sequence. [less ▲]

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See detailL’analyse acoustique des voix d’enfants de 5 ans : Proposition de valeurs de référence pour les logiciels PRAAT et VOCALAB
Sicard, Etienne; Meyrieux, Léa; Moreau, Mathilde et al

Poster (2019, May 14)

En clinique, les mesures acoustiques d’une voix sont comparées à des normes correspondant au genre, à l’âge et à la langue de l’individu. De telles normes sont disponibles pour les adultes mais sont plus ... [more ▼]

En clinique, les mesures acoustiques d’une voix sont comparées à des normes correspondant au genre, à l’âge et à la langue de l’individu. De telles normes sont disponibles pour les adultes mais sont plus rares pour les enfants, particulièrement les francophones en-deçà de 6 ans. Pour répondre à ce manque, Remacle et collaborateurs (2019) ont constitué un corpus de voix de 53 enfants normophoniques de 5 ans (26 filles ; 27 garçons), comportant la production des voyelles /a/, /i/, /u/ tenues. A partir de ce corpus, des valeurs de références pour les paramètres acoustiques ont été établies sous PRAAT (Remacle et al., 2019) et VOCALAB (Meyrieux & Moreau, 2018). L’objectif de cette étude est d’identifier les points de convergence/divergence entre les paramètres obtenus à l’aide des deux logiciels, sur base du corpus décrit ci-dessus. Compte tenu de l’absence de différence de l’appareil vocal (Cartei et al., 2014) et des paramètres acoustiques à 5 ans (Remacle et al., 2019), nous proposons une analyse groupée pour les filles et les garçons. Sur PRAAT, la F0 (méthode d’auto-corrélation), le shimmer, le Jitter et le NHR ont été extrait sur une portion stable d’une seconde au milieu de la voyelle tenue. Sur VOCALAB, les paramètres correspondants ont été extraits sur l'ensemble de la voyelle (Tableau 1). L’analyse du F0 montre une corrélation très forte des valeurs obtenues avec PRAAT et VOCALAB. Des différences importantes sont observées entre les indicateurs d’instabilité en fréquence et en amplitude des deux logiciels. Ces différences s’expliquent par le calcul court terme de PRAAT (à l’échelle d’un à dix cycles, d’une durée de quelques dizaines de ms) et le calcul combinant le court, moyen (100 ms) et long terme (1 sec) de VOCALAB, ainsi que par la portion du signal analysée (1 sec sur PRAAT et la voyelle entière sur VOCALAB). En revanche, le NHR de PRAAT et le rapport bruit/signal de VOCALAB montrent une corrélation négligeable à modérée selon la voyelle analysée. Ces résultats sont très proches de ceux obtenus pour des voix adultes précédemment publiés (Sicard & Menin-Sicard, 2013). L’analyse acoustique des voix d’enfants de 5 ans aura permis d'intégrer des repères d'indicateurs d'altération de la voix de jeunes enfants dans VOCALAB, sous forme d’un recoloriage des seuils voix normale/altérée (Figure 1). L’extrapolation entre les repères de l’enfant de 5 ans jusqu’à la puberté justifie toutefois la construction d’un corpus d’enfants âgés de 4 à 12 ans pour affiner les repères. [less ▲]

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See detailStudy of child placement in foster care : Analysis of sense of belonging and conflict of loyalties
Meens, Julie ULiege; Blavier, Adelaïde ULiege; Scali, Thérèse ULiege

Poster (2019, May 14)

The aim of this research was to question foster children and their family about their sense of belonging. Moreover, we questioned the children about their perception of the people constituting their ... [more ▼]

The aim of this research was to question foster children and their family about their sense of belonging. Moreover, we questioned the children about their perception of the people constituting their family. Finally, conflict of loyalties was investigated in order to understand how children felt living in a foster family while keeping in touch with their biological family. We used different tools including one we created, based on different indicators of sense of belonging and conflict of loyalties identified by previous research (ex. Buchanan, Maccoby & Dornbusch, 1991). The study was conducted with a population of 10 foster families. Our results highlighted the presence of a double sense of belonging for all the foster children (belonging to the foster family and at the same time, to the biological family). Nevertheless, most of children felt a stronger sense of belonging towards their foster family than to their biological family. We also discovered that the concept of "family" could be difficult to understand for some children, and that for others, this notion spontaneously included only the members of their host family. Finally, we showed the conflict of loyalties was present in the majority of families but in different intensities. [less ▲]

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See detailIs there a reduction in serial order working memory abilities in healthy aging?
Gregoire, Coline ULiege; Fay, Séverine; Majerus, Steve ULiege

Poster (2019, May 14)

The preservation of the ability to maintain information over the short-term in healthy aging remains a controversial question. Here we focused on one of the most challenging aspects of verbal working ... [more ▼]

The preservation of the ability to maintain information over the short-term in healthy aging remains a controversial question. Here we focused on one of the most challenging aspects of verbal working memory (WM), the ability to not only maintain verbal events but to also maintain their serial order of occurrence. An immediate serial recall task was administered to 30 young adults (18-30 years) and 30 older adults (60-80 years). Participants had to recall sequences of words or nonwords, from 2 to 7 items per sequence. They were matched for level of education and verbal intellectual efficiency Bayesian statistics showed moderate evidence for an absence of group effect for the total number of items recalled irrespectively of the items’ serial position (BF01 = 3,25 for words, BF01 = 1,26 for nonwords). When also scoring serial position information, we observed anecdotal evidence in favor of a group effect (BF10 = 2,9 for words; BF10 = 0,5 for nonwords). These results suggest that if there is a reduction of verbal WM abilities in healthy aging, it is very small and limited to the maintenance of serial order information. [less ▲]

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See detailOlder adults do not always rely on the amount of episodic details when judging the subjective quality of their memories
Folville, Adrien ULiege; D'Argembeau, Arnaud ULiege; Bastin, Christine ULiege

Poster (2019, May 14)

Although healthy aging is related to a decline in recollection asindexed by objective measures, the subjective experience of recollection remains stable.To date, however, studies have only examined these ... [more ▼]

Although healthy aging is related to a decline in recollection asindexed by objective measures, the subjective experience of recollection remains stable.To date, however, studies have only examined these age-related effects using aggregated data across trials, such that the relationship between subjective and objective measures of recollection on a trial-by-trial basis remains unknown. To address this question, young and older adults performed a cued recollection task of pictures that wereassociated with descriptive labels at encoding. At retrieval, participants were cued with the labels and were asked to rate the vividness of their memory of the picture and to recall as many details of the picture as they could.Multilevelanalyses revealed that, across trials, the relationship between subjective (vividness) and objective (free recall) recollection was stronger in young than inolder participants.However, when requested to recall the content of the picture before assessing vividness, older adults calibrated their subjective judgements on the amount of retrieved details to the same extent as young adults. These results provide evidence that older adults not only retrieve fewer episodic details but also rely on these details to a lesser extent than young adults for judging the subjective quality of their memories. [less ▲]

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See detailFear of falling and its correlates among people aged 65 and over
Léonard, Christina ULiege; SCHMITZ, Xavier ULiege; Adam, Stéphane ULiege et al

Poster (2019, May 14)

Fear of falling (FoF) is a real public health problem among elders. Indeed, this multi-determined phenomenon is highly prevalent in the elderly and leads to several negative physical and psychological ... [more ▼]

Fear of falling (FoF) is a real public health problem among elders. Indeed, this multi-determined phenomenon is highly prevalent in the elderly and leads to several negative physical and psychological consequences. Therefore, identify elders at risk of experiencing this fear is essential. By means of a two-year longitudinal study, we examined the relationships between different variables (i.e., sociodemographic, physical, psychological and cognitive variables) and FoF among 92 elders aged 65 and over. All participants were assessed twice (i.e., at the beginning and at the end of the study) with besides quarterly calls in order to report falls. We conducted univariate and multivariate logistic regression analyses. As expected, our multivariate model showed that a prior history of falls is a significant predictor of FoF. We also pointed out a higher tendency among women to experience FoF than among men. Furthermore, we showed, through univariate analyses, significant relationships between mood assessment and FoF. Moreover, our work attempted, in an originally way, to study the influences of subjective aging on FoF. Some results from the univariate analyses (e.g., participants with less positive attitudes towards the ageing process tend to experience more FoF) encourage researchers to carry out other studies in this direction. [less ▲]

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See detailLexical acquisition, generalization and Bayesian inference in children with Developmental Language Disorders
Dauvister, Estelle ULiege; Maillart, Christelle ULiege

Poster (2019, May 14)

Developmental Language Disorders (DLD) are characterized among others by word learning impairment. The mechanisms underlying these difficulties remain misunderstood. Bayesian theories of cognition offer ... [more ▼]

Developmental Language Disorders (DLD) are characterized among others by word learning impairment. The mechanisms underlying these difficulties remain misunderstood. Bayesian theories of cognition offer an interesting approach to study this phenomenon. It establishes inductive inference as a chore component of learning processes, based on the interaction of prior knowledge and environmental data. This study aims to determine if children with DLD can make inferences at two levels of abstraction, specific knowledge and rule acquisition, when prior knowledge is controlled, and if they can use prior knowledge as their peers do. Twenty children with DLD and twenty age-matched typically-developing children (6 to 12 year-old) were exposed to a new word learning task. Children are taught new categories of insects determined by particular physical characteristics that they have to infer. In a generalization task (second level of inference), they were presented with insects from unfamiliar categories. Finally, children are taught how physical properties relate to housing (baseline for prior knowledge) in a learning association task, and have to link each known insect with his housing. We assume that children with DLD would need more exposition to acquire similar bias in word learning and perform lower in the generalization task than their peers. [less ▲]

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See detailDefining ourselves: Past and future self-defining events increase the accessibility of psychological self-concepts
Garcia Jimenez, Claudia ULiege; D'Argembeau, Arnaud ULiege

Poster (2019, May 14)

Recent research suggests that the retrieval of self-defining memories (SDMs)—the memories of the most important events in our lives—influences an individual’s current sense of self and identity, notably ... [more ▼]

Recent research suggests that the retrieval of self-defining memories (SDMs)—the memories of the most important events in our lives—influences an individual’s current sense of self and identity, notably by increasing the tendency to conceptualize oneself in relation to psychological traits. In addition to being supported by such memories, our current sense of self may also be nourished by the anticipation of meaningful future events—referred to as self-defining future projections (SDFPs). To test this hypothesis, this study examined how SDFPs and SDMs modulate the current sense of self and identity. Three groups of participants wrote a description of a SDFP, a SDM or a non-self-related control topic, following which they had to provide ten stable aspects of their identity in the form of statements beginning with "I am". Participants engaging in SDFP and SDM descriptions generated significantly more psychological self-statements than those in the control condition. These results suggest that the act of projecting oneself into meaningful future events modulates the current sense of self to the same extent as autobiographical memory retrieval, by increasing the accessibility of psychological, trait-like self-conceptions. [less ▲]

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See detailThe role of semantic distance in learning and generalization of novel names in typically developing and atypically developing children
Witt, Arnaud; Thibaut, Jean-Pierre; Comblain, Annick ULiege

Poster (2019, May 14)

Children often learn the extension of novel words with a limited number of exemplars. There is evidence that the opportunity to compare stimuli is beneficial for learning and generalizing novel names in ... [more ▼]

Children often learn the extension of novel words with a limited number of exemplars. There is evidence that the opportunity to compare stimuli is beneficial for learning and generalizing novel names in typically developing (TD) children. This is important since they are in need of well-devised learning situations. We manipulated the role of semantic distance within training stimuli and between training and test stimuli and their influence on taxonomically-based generalization. We hypothesized more difficulties for ID children especially in “larger” semantic distance cases. Our results revealed that ID children were better than the matched TD children, suggesting functional lexical learning mechanisms. Even ID low-Raven-scores children, surprisingly, obtained better results than high-Raven-scores TD children. ID children, who were significantly older than TD children, could rely on their more developed world knowledge to learn and extend novel names. Close generalization was also significantly better than far generalization. We interpret our results in terms of cognitive constraints associated with comparison activities which might impact LR children in remote conceptual domains. We predict that ID participants should experience more difficulties with less familiar conceptual domains or with more difficult concepts such as relational concepts, which we currently test. [less ▲]

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See detailOpal-like CH3NH3PbI3 perovskite solar cells : effect of the 3D structuration on the conversion efficiency
Dewalque, Jennifer ULiege; Daem, Nathan ULiege; Spronck, Gilles ULiege et al

Poster (2019, May 13)

In this work, the 3D structuration of perovskite films is studied in order to highlight the effect of a periodic porous structure on the optical properties of the films (light harvesting, optical ... [more ▼]

In this work, the 3D structuration of perovskite films is studied in order to highlight the effect of a periodic porous structure on the optical properties of the films (light harvesting, optical coloration, semi-transparency…) and on the PV efficiency, in comparison with dense perovskite films usually used in planar solar cells configuration. The opal-like perovskite scaffold is obtained from templating fabrication method, with polystyrene beads as structuring agent. Five PS bead diameters are studied: 300 nm, 540 nm, 810 nm, 1.0 µm and 2.1 µm, to highlight the effect of the PS bead diameter on the optical properties of the films and on the PV efficiency. PbI2/CH3NH3I 0.7M in DMSO leads to the most covering, homogeneous and overlayer-free porous films. The PV efficiency of the corresponding cells increases with the bead diameter. A significant improvement in the PV conversion efficiency is observed thanks to the 3D structuration compared to a dense reference, due to the improvement of charge separation at the Spiro-OMeTAD/perovskite interface and thus to the reduction of charge recombination. In addition, CH3NH3PbI3 porous films prepared with 810 nm, 1000 nm and 2100 nm PS bead diameter respectively, are coloured, which is very interesting for building-integrated applications (BIPV). [less ▲]

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See detailLead-free double perovskite materials for photovoltaic application
Daem, Nathan ULiege; Dewalque, Jennifer ULiege; Spronck, Gilles ULiege et al

Poster (2019, May 13)

This work consists in studying the implementation of double perovskite materials in the form of thin film and showing the effect of the deposition conditions on the structural properties (uniformity ... [more ▼]

This work consists in studying the implementation of double perovskite materials in the form of thin film and showing the effect of the deposition conditions on the structural properties (uniformity, coverage rate, roughness, thickness, crystallinity, crystallite size) and on the optoelectronic properties (light absorption, electron-hole pair generation efficiency, charge diffusion length, recombination...). Before considering ultrasonic spray pyrolysis deposition, preliminary spin-coating tests are ongoing in order to verify the formation of Cs2AgBiBr6 phase according to the protocol reported by Greul et al. (J. Mater Chem A (2017), 19972-19981). The effect of precursors concentration, thermal post-treatment (hot plate/oven, temperature/duration), antisolvent dripping, relative humidity - which are reported as critical parameters for the preparation of high efficiency lead halides perovskite solar cells - on the layer morphology have been studied. The (micro)structural properties of the layers (uniformity, coverage rate, crystallite size, crystalline phase) have been characterized by scanning electron microscopy and X-ray diffraction. To improve charge collection within the lead-free double perovskite photoactive material, we have also investigated a mesoporous TiO2 network as an electron collecting material filled by Cs2AgBiBr6. Efficiencies of 1.7 % have been reached for our best PV cells which are very promising results. [less ▲]

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See detailOptimizing of TD-GC×GC-HRTOFMS for the profiling of cannabis blends
Dubois, Lena ULiege; Ledent, Maxime ULiege; Franchina, Flavio ULiege et al

Poster (2019, May 13)

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See detailRapid screening of complex biological matrices: Utilizing kendrick mass defect for group type evaluation of GC×GC-HR(EI)ToF/MS data
Weggler, Benedikt ULiege; Gruber, Beate; Zanella, Delphine ULiege et al

Poster (2019, May 13)

Characterization of highly complex matrices implicates scientific challenges such as wide presence of “true” unknowns, concentration ranges of various compound classes and limited, available amounts of ... [more ▼]

Characterization of highly complex matrices implicates scientific challenges such as wide presence of “true” unknowns, concentration ranges of various compound classes and limited, available amounts of sample. Cutting-edge, discovery based separation techniques such as multidimensional gas chromatography coupled to high-resolution time-of-flight mass spectrometry (GCxGC-HRToF/MS), are commonly applied to such analytical challenges. Nevertheless, most studies focus on target analysis and tend to disregard important details of the sample composition. The high separation capacity of GCxGC-ToF/MS allows for in-depth chemical analysis of the molecular composition. However, high amounts of data, containing several thousands of compounds per experiment, are generally acquired during such analyzes. Coupling GCxGC to high-resolution mass spectrometry (HRMS) further increases the amount of data and therefore requires advanced data reduction and mining techniques. Commonly, the main approach for the evaluation of dense data sets either focuses on the chromatographic separation for e.g. group type analysis, or utilizes exact mass data applying Kendrick Mass Defect (KMD) analysis or van Krevelen plots. The presented approach integrated the accurate mass data into the chromatographic information by combining KMD information and knowledge-based rules. This combination allows for fast, visual data screening as well as first quantitative estimation of the sample's composition. Moreover, the resulted sample classification significantly reduces the number of variables, allowing distinct chemometric analysis in non-targeted studies such as detailed hydrocarbon analysis (DHA), environmental and forensic investigations. [less ▲]

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See detailIn vitro characterization of lung inflammation mechanisms
Zanella, Delphine ULiege; Dejong, Thibaut; SCHLEICH, FLorence ULiege et al

Poster (2019, May 13)

Exhaled breath analysis has a high potential for early non-invasive diagnosis of lung conditions. Most of lung diseases involve a certain level of inflammation. The characterization of the ongoing ... [more ▼]

Exhaled breath analysis has a high potential for early non-invasive diagnosis of lung conditions. Most of lung diseases involve a certain level of inflammation. The characterization of the ongoing inflammation processes is crucial to define proper medication. The inflammation processes are associated with oxidative stress, which yields to the conversion of chemical from the membranes (as polyunsaturated fatty acids) into volatile compounds secreted by the lungs1. The understanding of the metabolic pathways involved in volatile markers production could open new therapeutic routes for inflammatory diseases. In this study, the lung inflammation was simulated in vitro. A549 epithelial cells, originally isolated from human alveoli, were cultured with and without oxidative agents (from chemical or biological origins) as part of a discovery study for lung inflammation mechanisms characterization. The cell culture volatile organic compounds (VOCs) were extracted by solid phase micro-extraction (SPME) and thermal desorption (TD) and analyzed by comprehensive two-dimensional gas chromatography hyphenated to time-of-flight mass spectrometers (GC×GC-TOFMS). The complete analytical workflow was optimized using central composite design model. On the processing side, different models were designed to compare the volatile profile of the epithelial cells in different inflammatory conditions. Univariate and multivariate feature selection approaches, i.e. Fisher Ratio and Random Forest, were then used to identify specific inflammatory markers. Based on the output, cross-comparison with metabolic pathways databases (e.g. KEGG) was performed. This work is setting up the basis of a multimodal and biomedical project on lung inflammation characterization. [less ▲]

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