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See detailCustomer-Perceived Intimacy through the Design of Healthscapes
Martens, Carmen ULiege; Delcourt, Cécile ULiege; Herssens, Jasmien

Poster (2019, July)

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See detailDimensional reduction of a quality of life questionnaire: is confirmatory factor analysis a powerful tool?
Dardenne, Nadia ULiege; POIRRIER, Anne-Lise ULiege; de Dorlodot, Clotilde et al

Poster (2019, July)

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See detailComparative Study of Reduced Order Modeling Techniques Applied to Geometrically Nonlinear Structures
Delhez, Elise ULiege; Nyssen, Florence; Batailly, Alain et al

Poster (2019, June)

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See detailProbing hippocampus’ functional properties with activation databases
Genon, Sarah ULiege; Plachti, Anna; Pinho, Ana Luisa et al

Poster (2019, June)

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See detailDifferent factorisation approaches of the Delis-Kaplan Executive System Battery converge towards a bi-factor model
Camilleri, Julia; Weis, Susanne; Chen, Ji et al

Poster (2019, June)

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See detailBien-être relationnel au doctorat & Style d'encadrement du promoteur
Christophe, Virginie ULiege

Poster (2019, May 20)

En Flandre (Belgique), il fut récemment démontré que 40,8% des doctorants vivent un stress constant et que 30,3% sont dans un état dépressif. Parmi les déterminants du mal-être au doctorat, l’on peut ... [more ▼]

En Flandre (Belgique), il fut récemment démontré que 40,8% des doctorants vivent un stress constant et que 30,3% sont dans un état dépressif. Parmi les déterminants du mal-être au doctorat, l’on peut retrouver la relation au promoteur. L’objectif de la présente étude fut d'évaluer deux facteurs pouvant impacter la qualité de cette relation, soit, l'impact du type d'encadrant et la satisfaction de la fréquence de rencontre avec le promoteur. [less ▲]

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See detailPHYSICO-CHEMISTRY, PROTEOMICS AND IN VIVO COMPARATIVE TESTS TO REVEAL VARIABILITY IN MULTISTRAIN PROBIOTIC FORMULATIONS
Razafindralambo, Hary ULiege; Correani, Virginia; Mattei, Benedetta et al

Poster (2019, May 18)

VSL#3 powder formulations originated from two production sites (USA- and ITALY-made products) were subjected to a physicochemical characterization based on thermal and colloidal properties [1], proteomics ... [more ▼]

VSL#3 powder formulations originated from two production sites (USA- and ITALY-made products) were subjected to a physicochemical characterization based on thermal and colloidal properties [1], proteomics analyses, and in vivointestinal permeability tests on animal models. Thermogravimetry-Differential Scanning Calorimetry (TGA-DSC) analyses provided powder sample profiles in mass and internal energy changes under temperature scan, and thermophysical data in terms of material decomposition and transition phases. Sample particle sizes, size distributions, and charges at the dispersed state informed on their capacity to remain stable in aqueous suspension. Table 1 compares physicochemical data generated from USA- and ITALY-made formulations obtained with different lots (lots DM538 and 10151198 analyzed after 0 and 3 months for USA vs.lots 512058 and 3302E10 analyzed after 0 and 3 months for ITALY). Even though both formulations were qualitatively similar in thermal and colloidal profiles, significant differences were quantitatively observed in terms of maximum decomposition temperature Tmax (p< 0.05), and transition phase temperature Tm (p < 0.01), as illustrated in Figure 1. Further comparative analyses by proteomics showed 99 proteins decreased abundances and 38 increased ones in ITALY-made batch (lot 512058) compared to the US-made one (lot DM538), and revealed differences in protein identities and origins. In vivo intestinal permeability tests with old mice confirmed such significant differences between US-made lot DM538 and IT-made lot 512058. In conclusion, the thermal scan data and shotgun proteomic comparisons demonstrate significant physicochemical and chemical variability between multistrain probiotic VSL#3 formulations from two manufacturer countries. Such differences have an impact on the intestinal permeability in vivo. [1] Razafindralambo, H. et al. (2018). Physico-chemical Approach for Characterizing Probiotics at the Solid and Dispersed States. Food Research International (In press). [less ▲]

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See detailFear of falling and its correlates among people aged 65 and over
Léonard, Christina ULiege; SCHMITZ, Xavier ULiege; Adam, Stéphane ULiege et al

Poster (2019, May 14)

Fear of falling (FoF) is a real public health problem among elders. Indeed, this multi-determined phenomenon is highly prevalent in the elderly and leads to several negative physical and psychological ... [more ▼]

Fear of falling (FoF) is a real public health problem among elders. Indeed, this multi-determined phenomenon is highly prevalent in the elderly and leads to several negative physical and psychological consequences. Therefore, identify elders at risk of experiencing this fear is essential. By means of a two-year longitudinal study, we examined the relationships between different variables (i.e., sociodemographic, physical, psychological and cognitive variables) and FoF among 92 elders aged 65 and over. All participants were assessed twice (i.e., at the beginning and at the end of the study) with besides quarterly calls in order to report falls. We conducted univariate and multivariate logistic regression analyses. As expected, our multivariate model showed that a prior history of falls is a significant predictor of FoF. We also pointed out a higher tendency among women to experience FoF than among men. Furthermore, we showed, through univariate analyses, significant relationships between mood assessment and FoF. Moreover, our work attempted, in an originally way, to study the influences of subjective aging on FoF. Some results from the univariate analyses (e.g., participants with less positive attitudes towards the ageing process tend to experience more FoF) encourage researchers to carry out other studies in this direction. [less ▲]

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See detailImproving Theory of Mind in Down syndrome ? An exploratory study
Comblain, Annick ULiege; Schmetz, Coraline

Poster (2019, May 14)

Background To communicate efficiently, it is important to understand the interlocutor’s perspective as well as the interlocutor’s feelings and emotions in a specific situation. These abilities are known ... [more ▼]

Background To communicate efficiently, it is important to understand the interlocutor’s perspective as well as the interlocutor’s feelings and emotions in a specific situation. These abilities are known to be impaired in DS children. It therefore makes sense to investigate the Theory of mind (ToM) development in this population. In our study, we explore the possibility of improving Down syndrome participants’ ToM abilities; these skills being important for understanding the subtleties of an interpersonal communication situation. Method DS subjects and typically developing children matched for non-verbal mental age were assessed. before and after a 10-weeks ToM multimodal training session. The pre- and post-test tasks came from the French adaptation of the ToM Inventory. Results At the end of the 10-weeks training, both trained group perform significantly better on ToM tasks that the untrained groups. Moreover, both trained show higher performances on pot-test than on pre-test whereas untrained groups performances remain stable. The DS trained group tend to perform better after the training session than the untrained typically developing children. Conclusion Results of our exploratory study are encouraging as they suggest that with a specific training DS children can improve their ToM abilities. [less ▲]

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See detailVirtual reality: A tool in the treatment of anxiety in stereotaxic radiotherapy?
Gamin, Nicolas ULiege; JANSEN, Nicolas ULiege; COUCKE, Philippe ULiege et al

Poster (2019, May 14)

Stereotaxic radiotherapy (SR) is an effective treatment for many types ofcancer but seems to cause anxiety. The purpose of this study is to determine whether experiencing the medical procedure by using ... [more ▼]

Stereotaxic radiotherapy (SR) is an effective treatment for many types ofcancer but seems to cause anxiety. The purpose of this study is to determine whether experiencing the medical procedure by using immersive virtual video can reduce preoperative anxiety. The experimental group (n=10) received information about the intervention and was exposed three times to the procedure before the SR. Two immersions took place in the days precedingthe intervention and the third took place just before the SR. The control group (n=10) only received information about the intervention. The STAI Y-A scale was used to measure state anxiety before and after each virtual immersion in the experimental group and just before and after the SR in both groups. We observed a similar decrease in anxiety across groups, which did not differ between them. Despite this result, it is important to point out that the experimental group reported a significant decrease in anxiety after the two immersions of day 1. The third immersion was not accompanied by a decrease of it. In conclusion, virtual reality seems useful in the treatment of preoperative anxiety, but its use is not enough to neutralize patient’s anxiety when approaching treatment [less ▲]

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See detailThe impact of age on the temporal compression of daily-life events in episodic memory
Folville, Adrien ULiege; Jeunehomme, Olivier ULiege; Bastin, Christine ULiege et al

Poster (2019, May 14)

Recent evidence suggests that the dynamic flow of information that constitutes daily-life events is remembered as moments of prior experience separated by temporal gaps. To date, however, how aging ... [more ▼]

Recent evidence suggests that the dynamic flow of information that constitutes daily-life events is remembered as moments of prior experience separated by temporal gaps. To date, however, how aging impacts this process of compression of past experience in episodic memory has received little attention. To examine this question, young and older adults incidentally engaged in daily-life activities while wearing a camera. Subsequently, participants were cued with pictures taken by the wearable camera and were asked to mentally relive corresponding events in as much detail as possible. Results revealed that rates of temporal compression of events when remembering were similar in young and older adults. In both groups, these rates of compression were higher when remembering goal-directed actions compared to spatial displacements. Furthermore, the amount of detail within recalled moments did not differ between age-groups. Taken together, these results support the view that episodic memories represent the unfolding of events as compressed short-time slices of past experience. Our findings also suggest that these mechanisms of compression remain stable with increasing age which highlights the importance of using ecological approaches that capture the complexity of real-life events to examine age-related changes in episodic memory. [less ▲]

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See detailA replication study of the relationships between depressive symptoms, behavioral activation and avoidance depending on gender
Krings, Audrey ULiege; Wagener, Aurélie ULiege; Blairy, Sylvie ULiege

Poster (2019, May 14)

Behavioral activation is a well-established empirical treatment of depression focusing on two psychological processes that are activation and avoidance. Little is known about the relations between ... [more ▼]

Behavioral activation is a well-established empirical treatment of depression focusing on two psychological processes that are activation and avoidance. Little is known about the relations between depressive symptoms and these two psychological processes. Then, this study investigates the predictive value of behavioral activation and avoidance on depressive symptoms. Since depression seems to be characterized by gender differences, this study investigates these relations depending on gender. Furthermore, gender differences in symptoms profiles are assessed. These two aims tend to replicate results from the study of Wagener, Baeyens & Blairy (2016). Three hundreds and sixteen adults completed self-report scales centered on depressive symptoms (BDI-II) and behavioral activation and avoidance (BADS-SF). As in the initial study, our results show (1) a significant difference in symptomatology depending on gender for sadness and loss of interest in sex, (2) positive predictive values of behavioral avoidance on almost all depressive symptoms in both gender except for increase of sleep, (3) negative predictive values of behavioral activation on almost all depressive symptoms in both gender except for decrease of sleep and loss of interest in sex. The strengths of some of these relationships are different in gender in both study, but no consistent results were observed. Results support the notion that (1) depression is characterized by symptoms differences in function of gender and (2) behavioral activation and avoidance are two psychological processes to target in psychotherapy of depression. [less ▲]

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See detailL’analyse acoustique des voix d’enfants de 5 ans : Proposition de valeurs de référence pour les logiciels PRAAT et VOCALAB
Sicard, Etienne; Meyrieux, Léa; Moreau, Mathilde et al

Poster (2019, May 14)

En clinique, les mesures acoustiques d’une voix sont comparées à des normes correspondant au genre, à l’âge et à la langue de l’individu. De telles normes sont disponibles pour les adultes mais sont plus ... [more ▼]

En clinique, les mesures acoustiques d’une voix sont comparées à des normes correspondant au genre, à l’âge et à la langue de l’individu. De telles normes sont disponibles pour les adultes mais sont plus rares pour les enfants, particulièrement les francophones en-deçà de 6 ans. Pour répondre à ce manque, Remacle et collaborateurs (2019) ont constitué un corpus de voix de 53 enfants normophoniques de 5 ans (26 filles ; 27 garçons), comportant la production des voyelles /a/, /i/, /u/ tenues. A partir de ce corpus, des valeurs de références pour les paramètres acoustiques ont été établies sous PRAAT (Remacle et al., 2019) et VOCALAB (Meyrieux & Moreau, 2018). L’objectif de cette étude est d’identifier les points de convergence/divergence entre les paramètres obtenus à l’aide des deux logiciels, sur base du corpus décrit ci-dessus. Compte tenu de l’absence de différence de l’appareil vocal (Cartei et al., 2014) et des paramètres acoustiques à 5 ans (Remacle et al., 2019), nous proposons une analyse groupée pour les filles et les garçons. Sur PRAAT, la F0 (méthode d’auto-corrélation), le shimmer, le Jitter et le NHR ont été extrait sur une portion stable d’une seconde au milieu de la voyelle tenue. Sur VOCALAB, les paramètres correspondants ont été extraits sur l'ensemble de la voyelle (Tableau 1). L’analyse du F0 montre une corrélation très forte des valeurs obtenues avec PRAAT et VOCALAB. Des différences importantes sont observées entre les indicateurs d’instabilité en fréquence et en amplitude des deux logiciels. Ces différences s’expliquent par le calcul court terme de PRAAT (à l’échelle d’un à dix cycles, d’une durée de quelques dizaines de ms) et le calcul combinant le court, moyen (100 ms) et long terme (1 sec) de VOCALAB, ainsi que par la portion du signal analysée (1 sec sur PRAAT et la voyelle entière sur VOCALAB). En revanche, le NHR de PRAAT et le rapport bruit/signal de VOCALAB montrent une corrélation négligeable à modérée selon la voyelle analysée. Ces résultats sont très proches de ceux obtenus pour des voix adultes précédemment publiés (Sicard & Menin-Sicard, 2013). L’analyse acoustique des voix d’enfants de 5 ans aura permis d'intégrer des repères d'indicateurs d'altération de la voix de jeunes enfants dans VOCALAB, sous forme d’un recoloriage des seuils voix normale/altérée (Figure 1). L’extrapolation entre les repères de l’enfant de 5 ans jusqu’à la puberté justifie toutefois la construction d’un corpus d’enfants âgés de 4 à 12 ans pour affiner les repères. [less ▲]

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See detailIs there a reduction in serial order working memory abilities in healthy aging?
Gregoire, Coline ULiege; Fay, Séverine; Majerus, Steve ULiege

Poster (2019, May 14)

The preservation of the ability to maintain information over the short-term in healthy aging remains a controversial question. Here we focused on one of the most challenging aspects of verbal working ... [more ▼]

The preservation of the ability to maintain information over the short-term in healthy aging remains a controversial question. Here we focused on one of the most challenging aspects of verbal working memory (WM), the ability to not only maintain verbal events but to also maintain their serial order of occurrence. An immediate serial recall task was administered to 30 young adults (18-30 years) and 30 older adults (60-80 years). Participants had to recall sequences of words or nonwords, from 2 to 7 items per sequence. They were matched for level of education and verbal intellectual efficiency Bayesian statistics showed moderate evidence for an absence of group effect for the total number of items recalled irrespectively of the items’ serial position (BF01 = 3,25 for words, BF01 = 1,26 for nonwords). When also scoring serial position information, we observed anecdotal evidence in favor of a group effect (BF10 = 2,9 for words; BF10 = 0,5 for nonwords). These results suggest that if there is a reduction of verbal WM abilities in healthy aging, it is very small and limited to the maintenance of serial order information. [less ▲]

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See detailImpact of personality and media on terrorism perception
De Cuyper, Marine ULiege; Delhalle, Marine; Blavier, Adelaïde ULiege

Poster (2019, May 14)

Research showed that terrorism perception is influenced by the media. In this context, this study aimed to study how personality influences terrorism perception through qualitative and quantitative ... [more ▼]

Research showed that terrorism perception is influenced by the media. In this context, this study aimed to study how personality influences terrorism perception through qualitative and quantitative methods. Participants (n=90) answered an online questionnaire that measured danger perception of terrorist events, the media influence as well as personality (BFI-Fr). Afterwards, a semi-directive interview was realized with a sample of the online questionnaire participants (n=30) in order to give substance to the previous observations. Results suggested that some personality dimensions – agreeability and neroticism – are linked to high level of terrorism perception in terms of threat perception, worrying, avoidance and relation to the media. Furthermore, the media as well as personal characteristics – age, gender and profession – influence terrorism perception. [less ▲]

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See detailOlder adults do not always rely on the amount of episodic details when judging the subjective quality of their memories
Folville, Adrien ULiege; D'Argembeau, Arnaud ULiege; Bastin, Christine ULiege

Poster (2019, May 14)

Although healthy aging is related to a decline in recollection asindexed by objective measures, the subjective experience of recollection remains stable.To date, however, studies have only examined these ... [more ▼]

Although healthy aging is related to a decline in recollection asindexed by objective measures, the subjective experience of recollection remains stable.To date, however, studies have only examined these age-related effects using aggregated data across trials, such that the relationship between subjective and objective measures of recollection on a trial-by-trial basis remains unknown. To address this question, young and older adults performed a cued recollection task of pictures that wereassociated with descriptive labels at encoding. At retrieval, participants were cued with the labels and were asked to rate the vividness of their memory of the picture and to recall as many details of the picture as they could.Multilevelanalyses revealed that, across trials, the relationship between subjective (vividness) and objective (free recall) recollection was stronger in young than inolder participants.However, when requested to recall the content of the picture before assessing vividness, older adults calibrated their subjective judgements on the amount of retrieved details to the same extent as young adults. These results provide evidence that older adults not only retrieve fewer episodic details but also rely on these details to a lesser extent than young adults for judging the subjective quality of their memories. [less ▲]

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See detailOpal-like CH3NH3PbI3 perovskite solar cells : effect of the 3D structuration on the conversion efficiency
Dewalque, Jennifer ULiege; Daem, Nathan ULiege; Spronck, Gilles ULiege et al

Poster (2019, May 13)

In this work, the 3D structuration of perovskite films is studied in order to highlight the effect of a periodic porous structure on the optical properties of the films (light harvesting, optical ... [more ▼]

In this work, the 3D structuration of perovskite films is studied in order to highlight the effect of a periodic porous structure on the optical properties of the films (light harvesting, optical coloration, semi-transparency…) and on the PV efficiency, in comparison with dense perovskite films usually used in planar solar cells configuration. The opal-like perovskite scaffold is obtained from templating fabrication method, with polystyrene beads as structuring agent. Five PS bead diameters are studied: 300 nm, 540 nm, 810 nm, 1.0 µm and 2.1 µm, to highlight the effect of the PS bead diameter on the optical properties of the films and on the PV efficiency. PbI2/CH3NH3I 0.7M in DMSO leads to the most covering, homogeneous and overlayer-free porous films. The PV efficiency of the corresponding cells increases with the bead diameter. A significant improvement in the PV conversion efficiency is observed thanks to the 3D structuration compared to a dense reference, due to the improvement of charge separation at the Spiro-OMeTAD/perovskite interface and thus to the reduction of charge recombination. In addition, CH3NH3PbI3 porous films prepared with 810 nm, 1000 nm and 2100 nm PS bead diameter respectively, are coloured, which is very interesting for building-integrated applications (BIPV). [less ▲]

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See detailLead-free double perovskite materials for photovoltaic application
Daem, Nathan ULiege; Dewalque, Jennifer ULiege; Spronck, Gilles ULiege et al

Poster (2019, May 13)

This work consists in studying the implementation of double perovskite materials in the form of thin film and showing the effect of the deposition conditions on the structural properties (uniformity ... [more ▼]

This work consists in studying the implementation of double perovskite materials in the form of thin film and showing the effect of the deposition conditions on the structural properties (uniformity, coverage rate, roughness, thickness, crystallinity, crystallite size) and on the optoelectronic properties (light absorption, electron-hole pair generation efficiency, charge diffusion length, recombination...). Before considering ultrasonic spray pyrolysis deposition, preliminary spin-coating tests are ongoing in order to verify the formation of Cs2AgBiBr6 phase according to the protocol reported by Greul et al. (J. Mater Chem A (2017), 19972-19981). The effect of precursors concentration, thermal post-treatment (hot plate/oven, temperature/duration), antisolvent dripping, relative humidity - which are reported as critical parameters for the preparation of high efficiency lead halides perovskite solar cells - on the layer morphology have been studied. The (micro)structural properties of the layers (uniformity, coverage rate, crystallite size, crystalline phase) have been characterized by scanning electron microscopy and X-ray diffraction. To improve charge collection within the lead-free double perovskite photoactive material, we have also investigated a mesoporous TiO2 network as an electron collecting material filled by Cs2AgBiBr6. Efficiencies of 1.7 % have been reached for our best PV cells which are very promising results. [less ▲]

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See detailSuccessful treatment of hand dystonia with Botulinum Toxin in a DYT12 patient
DEPIERREUX, Frédérique ULiege; PARMENTIER, Eric ULiege; HARDY, Pierre-Yves et al

Poster (2019, May 11)

We present the case of a young boy suffering from DYT12 (Rapid-onset dystonia-parkinsonism), presenting with generalized dystonia. Left hand dystonia has been treated successfully with botulinum toxin ... [more ▼]

We present the case of a young boy suffering from DYT12 (Rapid-onset dystonia-parkinsonism), presenting with generalized dystonia. Left hand dystonia has been treated successfully with botulinum toxin, under double guidance techniques (EMG and ultrasound) [less ▲]

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See detailToxic Cyanobacterial Blooms in Brussels: A Case Study
Van Hassel, Wannes ULiege; Huybrechts, Bart; Andjelkovic, Mirjana et al

Poster (2019, May 09)

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See detailBy-products show potential in glutathione production by engineered non-conventional yeast Yarrowia lipolytica
Do Thi Hoang Diem, ULiege; Steels, Sébastien ULiege; Denies, Olivia ULiege et al

Poster (2019, May 08)

Strong constitutive promoter pTEF were used to overexpress genes encoding the two enzymes (L-cysteine gamma-ligase and glutathione synthase) which catalyze the synthesis of GSH in Yarrowia lipolytica ... [more ▼]

Strong constitutive promoter pTEF were used to overexpress genes encoding the two enzymes (L-cysteine gamma-ligase and glutathione synthase) which catalyze the synthesis of GSH in Yarrowia lipolytica. Several strains which can overexpress GSH1 or GSH2 or both of them have been successfully obtained. The newly constructed strains for glutathione overproduction show different compared to control. [less ▲]

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See detailA systematic review of the secretome of skeletal muscle cells
Florin, Antoine ULiege; Lambert, Cécile ULiege; Sanchez, Christelle ULiege et al

Poster (2019, May 03)

This poster presents the preliminary results of a systematic review that summarized recent mass-spectrometry based proteomics discoveries of the secretome of skeletal muscle cells in response to disease ... [more ▼]

This poster presents the preliminary results of a systematic review that summarized recent mass-spectrometry based proteomics discoveries of the secretome of skeletal muscle cells in response to disease, exercise or metabolic stress. [less ▲]

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See detailUnravelling the evolutionary processes that shaped the diversity of the amphipod genus Eusirus in the Southern Ocean
Salabao, Louraine ULiege; Frederich, Bruno ULiege; Lepoint, Gilles ULiege et al

Poster (2019, May)

Various evolutionary processes greatly influenced by the geological and climatic history shaped the diversity of the current Antarctic marine fauna. In the past, these Antarctic species have survived ... [more ▼]

Various evolutionary processes greatly influenced by the geological and climatic history shaped the diversity of the current Antarctic marine fauna. In the past, these Antarctic species have survived different glacial cycles through dispersal to refugia, and/or adaptations to novel abiotic and biotic conditions. With the increasing temperatures in the polar regions, marine fauna is currently faced with three possible outcomes: adaptation, migration or extinction. Based on how these organisms were able to survive environmental changes in the past will allow us to predict their future response. In this study, amphipods of the genus Eusirus are as model organisms as knowledge on their ecology and biogeography is still very limited. The evolutionary history of Eusirus amphipods is phylogenetically reconstructed through time with molecular data. DNA sequence data are obtained by sequencing the complete mitochondrial genomes, using a combination of skimming sequencing and long-range PCRs amplicons of different Eusirus species. Mitochondrial data will be complemented with additional sequence data from nuclear genes. Time-calibrated phylogenies will be used as basis for plotting ecological and trophic data generated by stable isotope analyses as well as morphological information. By combining data from time-calibrated phylogenies as well as from ecology and morphology, we aim to understand the evolutionary processes that led to the current diversity of Eusirus amphipods. [less ▲]

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See detailDevelopment of Nanovectors for the Targeted Delivery in Anopheles Mosquitoes of Drugs against Plasmodium Parasites
Siden-Kiamos1, Inga; Deligianni, Elena; Spanos, Lefteris et al

Poster (2019, May)

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See detailInfluence of a hamstring eccentric training on strength and flexibility: a randomized controlled trial
Delvaux, François ULiege; Schwartz, Cédric ULiege; Decréquy, Thibault et al

Poster (2019, April 28)

Introduction Muscle imbalances and poor flexibility are frequently described as risk factors for hamstring injury. Preventive strategies should include eccentric exercises (2, 3), but the influence of ... [more ▼]

Introduction Muscle imbalances and poor flexibility are frequently described as risk factors for hamstring injury. Preventive strategies should include eccentric exercises (2, 3), but the influence of multiple, on-field eccentric exercises on these risk factors remains unclear. The main purpose of this study was to investigate the efficacy of an on-field hamstring eccentric program on strength, passive and active flexibility of hamstring muscles. Methods Twenty-seven male amateur athletes (22.7±1.9 years, 182±9 cm, 75.1±10.4 kg) were randomly assigned to intervention (n = 13) or control group (n = 14). The intervention group was instructed to perform 15 sessions of four progressively increased eccentric exercises (single-leg Roman dead-lift T-drop, slide leg exercise, Askling’s “glider” and Nordic Hansmtring exercise) during a 6-week period. Both groups were assessed as follows: isokinetic (hamstring and quadriceps) strength and hamstrings-to-quadriceps ratios (Cybex Humac Norm® dynamometer (CSMI, Stoughton, USA)), ranges of motion during passive flexibility (straight leg raise - SLR) and active flexibility (Askling’s H test)(1) using an optoelectronic 3D system (Codamotion® CX1 units (Charnwood Dynamics, Rothley, UK)). Results In the intervention group, passive SLR was significantly increased by 11.4° (+12.7%, p<0.001, large effect size), but not active flexibility (+3.1%, p>0.05)(Figure 1). Hamstring eccentric peak torque (+7.1-8%), eccentric body weight normalized peak torque (+7.6-8%) and functional ratios (+8.9-9.3%) were significantly increased (p<0.05, small to medium effect size) in both dominant and non dominant legs of the intervention group participants. No modifications of strength or flexibility were observed in the control group (p>0.05). Conclusions A 6-week eccentric program, including four on-field exercises for hamstring muscles, is an effective method of improving several hamstring injury risk factors such as passive flexibility, eccentric strength and functional ratios. As this program may be easily implemented in a real-world context, an association of multiple eccentric exercises might be useful in an injury prevention strategy, especially in amateur athletes. References (1) Askling CM, Nilsson J, Thorstensson A. A new hamstring test to complement the common clinical examination before return to sport after injury. Knee Surg Sports Traumatol Arthrosc Off J ESSKA. 2010; 18(12):1798–803. (2) Guex KJ, Lugrin V, Borloz S, Millet GP. Influence on Strength and Flexibility of a Swing Phase-Specific Hamstring Eccentric Program in Sprinters’ General Preparation. J Strength Cond Res. 2016; 30(2):525–32. (3) van der Horst N, Smits D-W, Petersen J, Goedhart EA, Backx FJG. The preventive effect of the nordic hamstring exercise on hamstring injuries in amateur soccer players: a randomized controlled trial. Am J Sports Med. 2015; 43(6):1316–23. [less ▲]

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See detailFrom noise to signal: Kendrick mass filtering for high-resolution mass spectrometry imaging analysis
Mc Cann, Andréa ULiege; Kune, Christopher ULiege; Arguelles Arias, Anthony ULiege et al

Poster (2019, April 14)

Introduction Over the last years, lots of progress have been done in the development of mass spectrometry imaging, making the technique more and more accessible for various applications, such as ... [more ▼]

Introduction Over the last years, lots of progress have been done in the development of mass spectrometry imaging, making the technique more and more accessible for various applications, such as biomarkers discovery or bioactive compounds identification. However, the progresses made in terms of spatial and instrumental resolution has for consequences the dramatic increase of dataset size, shifting the burden from data production to data analysis. We propose here to use a semi-targeted method based on Kendrick mass defect (KMD) analysis to immediately identify the chemistry-related compounds in mass spectrometry imaging applied to microbiology samples. Thanks to an in-house software, we are now able to better understand the bacteria-bacteria interactions. Materials and methods Bacillus velezensis GA1 and Pseudomonas sp. CMR12a were inoculated on a semi-solid agar-based medium and incubated at 30°C. Region of interest was cut directly from the petri dish and transferred to the target ITO plate, previously covered with double sided conductive carbon tape. This assembly was then put in a vacuum desiccator until complete drying (overnight), and covered with HCCA matrix. Mass spectrometry images were obtained using a FT-ICR mass spectrometer (9.4T SolariX, Bruker Daltonics, Bremen, Germany). Data analysis was performed on an in-house software. Results & Discussion Thanks to the KMD analysis, we were able to directly compare and identify the nature of the compounds detected in MSI such as lipids (1) or lipopeptides (2a), without the need of an extensive database search. It was also possible to identify some lipopeptides degradation occurring nearby Pseudomonas (2b). Thanks to our in-house software, the compounds with a similar chemistry can now be filtrated and the image can be reconstructed, removing thus the noise and focusing only on the signal. [less ▲]

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See detailImpact of lower stratospheric dynamical variability on total inorganic fluorine derived from ground-based FTIR, satellite and model data
Prignon, Maxime ULiege; Bernath, P. F.; Chabrillat, S. et al

Poster (2019, April 12)

Long-lived tracer concentrations in the lower stratosphere are affected by short time scale circulation variability as highlighted by recent papers (e.g., Mahieu et al., 2014). Many tracers, such as ... [more ▼]

Long-lived tracer concentrations in the lower stratosphere are affected by short time scale circulation variability as highlighted by recent papers (e.g., Mahieu et al., 2014). Many tracers, such as hydrogen chloride (HCl) or hydrogen fluoride (HF) have now been successfully used to investigate or identify this variability (e.g., Harrison et al., 2016) In this work, the main reservoirs of inorganic fluorine [i.e., HF, carbonyl fluoride (COF2) and carbonyl chloride fluoride (COClF)] and their sum (total inorganic fluorine, Fy) are used to investigate the lower stratospheric circulation changes. We use Fourier Transform InfraRed (FTIR) ground-based observations conducted in the framework of the NDACC network (http://www.ndacc.org) to derive column abundances of HF and COF2, thus providing a good proxy for Fy. To support this research, we also include satellite observations from HALOE (HF available) and ACE-FTS (HF, COF2 and COClF available). Moreover, we use the Chemical-Transport Model (CTM) BASCOE (Belgian Assimilation System for Chemical ObsErvations; Chabrillat et al., 2018) to evaluate the representation of the investigated circulation changes in state-of-the-art meteorological reanalyses. We also evaluate if WACCM4 (Whole Atmosphere Community Climate Model version 4) is able to reproduce these changes through a free dynamics and free chemistry run. Finally, SLIMCAT CTM (Chipperfield et al., 2015) simulations are included to provide information on the partitioning between the main Fy reservoirs. [less ▲]

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See detailRestoring a worn-out pasture: what impact on N2O exchanges ?
Lognoul, Margaux ULiege; Gourlez de la Motte, Louis ULiege; Naiken, Alwin ULiege et al

Poster (2019, April 08)

A paired-flux tower experiment was set up in a 40 y-o grazed pasture managed by a local farmer. A parcel under restoration was compared to a control plot. In addition to N2O flux monitoring, soil mineral ... [more ▼]

A paired-flux tower experiment was set up in a 40 y-o grazed pasture managed by a local farmer. A parcel under restoration was compared to a control plot. In addition to N2O flux monitoring, soil mineral N content (ammonium and nitrate) was measured every 10-15 days. [less ▲]

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See detailEtude de composés organiques volatils (COVs) émis lors de l'interaction hôte - pathogène par des souches produisant des mycotoxines.
Josselin, Laurie ULiege; De Boevre, Marthe; De Clerck, Caroline ULiege et al

Poster (2019, April 03)

Method for the qualitative detection (SPME) of VOCs emitted by toxigenic (mycotoxin-producing) and non-toxigenic (non mycotoxin-producing) strains.

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See detailStress-related accumulation of arabidopsides: impact on chloroplast membranes
Genva, Manon ULiege; Deleu, Magali ULiege; Andersson, M.X. et al

Poster (2019, April)

Oxylipins are crucial agents in plant defense mechanisms. While free oxylipins are well studied, roles of esterified oxylipins remain unclear. Esterified oxylipins are structurally diverse metabolites ... [more ▼]

Oxylipins are crucial agents in plant defense mechanisms. While free oxylipins are well studied, roles of esterified oxylipins remain unclear. Esterified oxylipins are structurally diverse metabolites that were found in diverse plant species, suggesting that those may be more ubiquitous that currently thought. Among those, galactolipids containing (dn)OPDA were discovered, firstly in A. thaliana, but also in other plants. Those molecules, named arabidopsides, are highly induced under stress conditions, as it accumulates up to 8 percent of plant lipids, but their precise contributions in plant defense mechanisms are still unknown. Arabidopsides are directly formed in plant chloroplast membranes from galactolipids. Accumulation of arabidopsides in such high quantity in chloroplast membranes may modify their properties (e.g. photosynthetic activity). This study aims to understand the impact of arabidopside presence in chloroplast membranes on their properties using biomimetic plant membranes via complementary in silico and in vitro approaches. Interfacial properties of arabidopsides and non-oxidized galactolipids were studied using Langmuir film balance. Results showed that arabidopsides possess different interfacial properties compared to non-oxidized chloroplast lipids. Arabidopsides ability to permeabilize chloroplast membranes was also studied in vitro. Arabidopsides A and B are able to permeabilize chloroplast membranes while arabidopside D is not. In conclusion, arabidopside production by plants under stress conditions may modify chloroplast membrane properties such as its permeability. As chloroplast membrane lipid composition is essential to its photosynthetic ability, such changes may also affect its function. [less ▲]

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See detailCoupling of the ocean model NEMO to the regional climate model MAR over Greenland
Sievers, Imke ULiege

Poster (2019, April)

The Arctic is currently undergoing rapid changes with major effect on the global climate system. Since the Arctic is a ruff environment which is hard to sample with observations, modelling is often chosen ... [more ▼]

The Arctic is currently undergoing rapid changes with major effect on the global climate system. Since the Arctic is a ruff environment which is hard to sample with observations, modelling is often chosen to understand the different processes and interactions at play. Most regional modelling efforts however focus on only one component of the arctic climate system at a time (ocean, atmosphere, ice sheet) and therefore, neglect that many climate components are linked to each other. To fully grasp all the interactions involved in the Arctic climate system we will present first results of a coupling of an atmosphere-ocean regional climate model with an integrated sea ice model which is set up around Greenland in the framework of the Belgian PARAMOUR project. The models used are the regional climate model MAR (at a resolution of 15km), which is especially designed to model the Polar regions, and the ocean model NEMO with the integrated ice model LIM at a resolution of 1/16°. By coupling these high resolved models we aim to get a better insight into the small scale interactions between atmosphere, ocean as well as the Greenland Ice Sheet Surface Mass Balance, and with this insight contribute to a better understanding of the arctic climate system. [less ▲]

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See detailIon mobility mass spectrometry for lipopeptides analysis
Mc Cann, Andréa ULiege; Kune, Christopher ULiege; Far, Johann ULiege et al

Poster (2019, March 31)

Cyclic lipopeptides (CLPs) are produced by bacteria in a ribosome independent manner and consists in a hydrophilic peptide linked to a B-hydroxy fatty acid chain. Despite CLPs have relatively low ... [more ▼]

Cyclic lipopeptides (CLPs) are produced by bacteria in a ribosome independent manner and consists in a hydrophilic peptide linked to a B-hydroxy fatty acid chain. Despite CLPs have relatively low molecular weight (between 800 and 2,000 Da), the analysis of lipopeptides remains challenging due to the wide variety of synthetized isoforms differing in fatty acid chain length, in methyl group branching position, and in the nature of the amino-acids residues. These isoforms are suspected to have different biological activities requiring development of reliable methods for CLPs identification and characterization. In this work, we present an original approach combining UPLC and ion mobility - mass spectrometry at high resolving powers to separate and identify the different species. Lipopeptides were separated by UPLC (I-class, Waters, U.K.) on a C18 BEH column and identified by CID MS/MS mass spectrometry. Ion mobility – mass spectrometry (IM-MS) measurements were performed on a trapped Ion Mobility Mass Spectrometer (TimsTOF, Bruker Daltonics, U.S.A.). Accurate Collison Cross Section (CCS) were obtained in both positive and negative mode and compared with theoretical CCS obtained by the trajectory method from IMoS V2. Separation of lipopeptides such as surfactins, iturins, or mycosubtilins was successfully performed by reverse phase liquid chromatography. Lipopeptides were separated according to lipid chain length and according to the branching position of the methyl group (iso/anteiso/linear). Ion mobility analysis with computational chemistry support gave additional information on the lipopeptides structure and family. Structural information are obtained by experimental and theoretical CCS comparison while the lipopeptides family could be determined with CCS/mass trends. These results pave the way to a new strategy for fast lipopeptides identification and could potentially contribute to lipopeptides structure elucidation. [less ▲]

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See detailProbing the Mechanochemical Properties of a Single Molecular Knot by AFM
Sluysmans, Damien ULiege; Zhang, Liang; Leigh, David A. et al

Poster (2019, March 26)

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See detailHot melt extrusion as a solvent-free technique for the formation of a polymeric amorphous solid dispersion of atorvastatin
Jennotte, Olivier ULiege; Koch, Nathan ULiege; Collard, Laurence ULiege et al

Poster (2019, March 26)

Hot-melt extrusion as a solvent-free technique for the enhancement of BCSII molecules.

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See detailProbing the Motion of a Single Molecular Rotor by AFM.
Devaux, Floriane ULiege; Li, Xun ULiege; Sluysmans, Damien ULiege et al

Poster (2019, March 26)

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See detailInvestigation into the Mechanochemical Properties of Single Artificial Molecular Switches by AFM.
Sluysmans, Damien ULiege; Bruns, Carson; Zhang, Long et al

Poster (2019, March 26)

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See detailAssessment of drug skin tolerance in Africans using chromameter
Sounouvou, Axel Gérald Hope Tognidé ULiege; Quetin-Leclercq, Joëlle; Piel, Géraldine ULiege et al

Poster (2019, March 26)

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See detailCapillary electrophoresis and microscale thermophoresis in fragment-based drug discovery : development of screening bioassays towards FXIIa
Davoine, Clara ULiege; Farças, Elena; Thabault, Léopold et al

Poster (2019, March 24)

Tackling thrombotic disorders without affecting the hemostatic capacity remains a challenge in medicine. One of the strategies in the search for safer antithrombotic therapies is to target coagulation ... [more ▼]

Tackling thrombotic disorders without affecting the hemostatic capacity remains a challenge in medicine. One of the strategies in the search for safer antithrombotic therapies is to target coagulation factor XIIa (FXIIa).[1] This strategy have two substantial advantages : 1. No bleeding risk 2. Additional anti-inflammatory effects After limited results with the traditional medicinal chemistry approach (inhibitors in the μM range) [2], we decided to apply fragment-based drug discovery approach (FBDD). In its first step, FBDD strongly depends on the ability to detect and gauge weak affinity binders. In the scope of validating the fragment hits, the most robust strategy is to apply orthogonal techniques. In this work, we investigate the suitability of microscale thermophoresis and capillary electrophoresis for the discovery of new fragments that bind FXIIa. [1] a) J.I.Weitz, Thromb Res, 141 Suppl 2 (2016) S40-45; b) J.C. Fredenburgh, P.L. Gross, J.I. Weitz, Blood, 129 (2017) 147-154; c) A.T. Long, E. Kenne, R. Jung, T.A. Fuchs, T. Renne, J Thromb Haemost, 14 (2016) 427-437. [2] a) S. Robert, C. Bertolla, B. Masereel, J.M. Dogné, L. Pochet, Journal of Medicinal Chemistry, 51 (2008) 3077-3080; b) C. Bouckaert, S. Serra, G. Rondelet, E. Dolušić, J. Wouters, J.M. Dogné, R. Frédérick, L. Pochet, Eur J of Med Chem, 110 (2016) 181-194 [less ▲]

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See detailValidation d’un score pré-opératoire prédisant la survie à long terme du cholangiocarcinome intra-hépatique réséqué : étude de cohorte multicentrique internationale
Brustia, R; Serena, L; Kawai, T et al

Poster (2019, March 23)

IntroductionRécemment, un score pré-opératoire en 5 classes (SCORE_CCIH) capable de prédire le taux de survie à 5 ans après hépatectomie pour cholangiocarcinome intrahépatique (CCIH) et derivé d'une ... [more ▼]

IntroductionRécemment, un score pré-opératoire en 5 classes (SCORE_CCIH) capable de prédire le taux de survie à 5 ans après hépatectomie pour cholangiocarcinome intrahépatique (CCIH) et derivé d'une cohorte internationale de 250 malades, a été proposé (1). Le but de ce travail était de valider ce score sur une cohorte externe afin qu’il soit utilisé en pratique clinique. Patients et Methodes Tous les malades opérés d’un CCIH depuis 2001 dans 9 centres internationaux ont été inclus. Les données minimales du SCORE-CCIH étaient : albumine, leucocytes/neutrophiles, CA19-9 et diamètre tumoral pré-opératoire. Le critère de jugement principal était la précision de discrimination du SCORE_CCIH par l’aire sous la courbe ROC. Une analyse de survie et un modèle de COX ont été réalisés pour déterminer les facteurs prédictifs indépendants de mortalité. Résultats Parmi 330 patients inclus, la survie moyenne était de 64±4 mois. La précision de discrimination du SCORE_CCIH (AUROC) sur la survie était de 0,63 (95%CI:0,57-0,69) (fig.1). Le taux de survie à 5 ans observée était de 35,2%, 29,5%, 15,2%, 15,7% et 0% en fonction des classes (fig.2). Après ajustement dans le modèle de Cox, les variables significativement prédictives de mortalité étaient le taux d’albumine (HR:0,671, IC95%:0,461-0,976 p=0,04), le rapport leucocytes/neutrophiles (HR: 1,091, IC95%:1,012- 1,176 p=0,02) et le taux de CA19-9 (HR :1, IC95%:1-1, p=0,015). Discussion La précision du CCIH_SCORE sur la discrimination de la survie à long terme est modérée. Les prédicteurs indépendants associés à la mortalité étaient albumine, leucocytes/neutrophiles, CA19-9 mais pas le diamètre tumoral. Conclusion Le SCORE_CCIH peut etre consideré en pratique clinique comme aide à la décision en cas de malades complexes. [less ▲]

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See detailTypically and Atypically Developing Children' Generalizations of Novel Names: the Role of Semantic Distance
Witt, Arnaud; Comblain, Annick ULiege; Thibaut, Jean-Pierre

Poster (2019, March 22)

Children often learn the extension of novel words with a limited number of exemplars. There is evidence that the opportunity to compare stimuli is beneficial for learning and generalizing novel names in ... [more ▼]

Children often learn the extension of novel words with a limited number of exemplars. There is evidence that the opportunity to compare stimuli is beneficial for learning and generalizing novel names in typically developing (TD) children (e.g., Gentner, 2010). However, so far,, comparison situations have not been studied in children with intellectual disabilities (ID) (Chapman & Kay-Raining Bird, 2012). This is important since they are in need of well-devised learning situations. We manipulated the role of semantic distance within training stimuli and between training and test stimuli and their influence on taxonomically-based generalization. We hypothesized more difficulties for ID children especially in “larger” semantic distance cases. [less ▲]

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See detailA low-order analytical model to monitor tension in shallow cables with specific end conditions
Geuzaine, Margaux ULiege; Denoël, Vincent ULiege

Poster (2019, March 15)

In order to remotely monitor tension in a cable over time, an appropriate method is based on the natural frequencies of the cable measured by means of wireless accelerometers. In this paper, an existing ... [more ▼]

In order to remotely monitor tension in a cable over time, an appropriate method is based on the natural frequencies of the cable measured by means of wireless accelerometers. In this paper, an existing method is extended to determine the tension in long or short shallow cables with small bending stiffness and arbitrary end conditions. First, a low-order analytical model is developed to compute the dynamic response of a given cable. Then, the unknown parameters such as the end conditions, the exact length of the cable and the tension in the cable are adjusted, using an iterative nonlinear least-square algorithm, until the computed natural frequencies and associated mode shapes match the measured ones. This procedure is finally validated with field measurements collected on long and short cables. [less ▲]

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See detailCOL1A2 mutation in a case of isolated short stature
HARVENGT, Julie ULiege; Boros, E.; BULK, Saskia ULiege et al

Poster (2019, March 15)

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See detailInternational validation of the Phone Outcome Questionnaire for patients with Disorders Of Consciousness
Wolff, Audrey ULiege; Estraneo, Anna; Noé, Quique et al

Poster (2019, March 15)

Assessing the evolution of severely brain-injured patients with disorders of consciousness (DOC) with current tools like the Glasgow Outcome Scale-Extended (GOS-E) remains a challenge. At the bedside, the ... [more ▼]

Assessing the evolution of severely brain-injured patients with disorders of consciousness (DOC) with current tools like the Glasgow Outcome Scale-Extended (GOS-E) remains a challenge. At the bedside, the most reliable diagnostic tool is currently the Coma Recovery Scale-Revised. The CRS-R distinguishes patients with unresponsive wakefulness syndrome (UWS) from patients in minimally conscious state (MCS) and patients who have emerged from MCS (EMCS). This international multi-centric study aims to validate a phone outcome questionnaire (POQ) based on the CRS-R and compare it to the CRS-R performed at the bedside and to the GOS-E which evaluates the level of disability and assigns patient’s in outcomes categories. The POQ will allow clinicians to probe the evolution of patient’s state of consciousness based on caregivers feedback. This research project is part of the International Brain Injury Association, Disorders of Consciousness-Special Interest Group (DOCSIG) and DOCMA consortium. [less ▲]

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See detailPupil diameter and Behavioral Responsiveness in Disorders of Consciousness
Mortaheb, Sepehr ULiege; Bonin, Estelle ULiege; Laureys, Steven ULiege et al

Poster (2019, March 15)

The clinical diagnosis of consciousness is mainly based on bedside observation of the patient's responses using standardized neurobehavioral scales. By definition, it is common to observe vigilance ... [more ▼]

The clinical diagnosis of consciousness is mainly based on bedside observation of the patient's responses using standardized neurobehavioral scales. By definition, it is common to observe vigilance fluctuation in patients in minimally conscious state (MCS) who would show reproducible but fluctuating signs of consciousness [1]. As the probability to detect voluntary responses depends on the patient's level of vigilance at the time of assessment, multiple assessments are needed in order to detect signs of consciousness and avoid misdiagnosis [2]. If this fluctuation is known in disorders of consciousness (DOC), it remains poorly understood and characterized. In this study, we investigated the relationship between pupil diameter (suggested as an objective physiological measure of alertness level in healthy subjects [3-6]) and behavioral responsiveness in DOC patients. To this end, five patients with chronic DOC (1 unresponsive wakefulness syndrome [UWS; ie, reflexive responses], 2 MCS- [ie, signs of consciousness but no signs of language preservation, 2 MCS+ [ie, signs of language preservation]; 3 males; age=47±15.16 (median ± SD), median TSI=284 days) were enrolled. For each patient, four behavioral assessments were performed in a single day using the Coma Recovery Scale-Revised. Before each assessment, pupil response was recorded for 10 minuttients (MCS-) was excluded from the analysis due to eye closure during whole recording period. Pupil diameter was recorded using Phasya Drowsimeter R100 glasses (eye images acquired at 120 Hz with a high-speed camera integrated into the glasses). Eye closure periods were marked manually. Several parameters were investigated: eye opening percentage (EOP), as well as median, variance, entropy, and Lempel-Ziv complexity of the pupil diameter. We here provide preliminary descriptive results for this small sample. We observed lower EOP and median pupil diameter when the patients were unresponsive (i.e., diagnosis of UWS) vs. when they were responsive at bedside (i.e., MCS; median EOP=74.78% vs 99.6%, median pupil diameter=21 vs 28). Variance did not show any specific pattern; however, complexity measures of entropy and Lempel-Ziv were also lower in the UWS (median entropy=9.83 vs 10.58 and median Lempel-Ziv complexity=121 vs 328). Median pupil diameter also seemed to be more sensitive to behavioural changes across different assessments. These preliminary data suggest that higher responsiveness is related to higher median and complexity of the pupillometry signal and eye opening percentage at rest, supporting that pupillometry markers could be used as potential predictor of behavioral responsiveness in DOC patients. [less ▲]

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See detailEarly listeriosis after liver transplantation: report of 2 cases
PIETTE, E; VANDERMEULEN, Morgan ULiege; MEURISSE, Nicolas ULiege et al

Poster (2019, March 14)

Listeria monocytogenes is a rare cause of potentially lethal infection and sepsis in transplant patients. Listeriosis is usually described after kidney or bone marrow transplant, and has rarely been ... [more ▼]

Listeria monocytogenes is a rare cause of potentially lethal infection and sepsis in transplant patients. Listeriosis is usually described after kidney or bone marrow transplant, and has rarely been reported after liver transplantation. Here, the authors present two cases of severe Listeria infection occurring within three months after complicated liver transplantation in patients still recovering on the ward. The patients were successfully treated by intravenous ampicillin. These cases should remind transplant physicians that listeriosis may develop in liver recipients, that food safety advice should be provided, and that intravenous ampicillin might be an effective treatment for systemic listeriosis in solid organ recipients. [less ▲]

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See detailNociception Coma Scale Revised allows to identify patients with preserved neural basis for pain experience.
Bonin, Estelle ULiege; Lejeune, Nicolas; Thibaut, Aurore ULiege et al

Poster (2019, March 14)

The Nociception Coma Scale-Revised (NCS-R) was developed to help assessing pain in non-communicative patients with disorders of consciousness (DOC). Several studies have shown its sensitivity in assessing ... [more ▼]

The Nociception Coma Scale-Revised (NCS-R) was developed to help assessing pain in non-communicative patients with disorders of consciousness (DOC). Several studies have shown its sensitivity in assessing responses to acute noxious stimuli. However, they failed to determine a reliable cut-off score that could be used to infer pain processing in these patients. This retrospective cross-sectional study aimed to determine an NCS-R cut-off score supporting preserved neural basis for pain experience, based on brain metabolism as measured by fluorodeoxyglucose positron emission tomography (FDG-PET). We included FDG-PET confirmed patient with unresponsive wakefulness syndrome (UWS) (n=13) and looked at their highest NCS-R total scores. As the highest score was 4, we determined the cut-off of 5 and compared the brain metabolism of these patients with matched DOC patients with a cut-off score ≥ 5 (i.e., potential pain) and healthy controls. We found a higher global cerebral metabolism in healthy subjects compared with both patients’ groups and also in patients with potential pain compared with FDG-PET confirmed UWS. We observed a preserved metabolism in the left insula in patients with potential pain when compared with FDG-PET confirmed UWS. We also found a preservation of the connectivity between the left insula and the medial frontal gyrus in patients with potential pain compared with FDG-PET confirmed UWS. Our data suggest that using the cut-off score of 5 can be helpful to improve pain management in DOC patients. Future studies should focus on patients showing scores below this cut-off to better characterize their profile and improve cares. [less ▲]

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See detailUnderstanding the biodiversity and evolutionary history of the amphipod genus Eusirus in the Southern Ocean
Salabao, Louraine ULiege; Frederich, Bruno ULiege; Lepoint, Gilles ULiege et al

Poster (2019, March 13)

The diversity of the Antarctic marine fauna has been shaped by various evolutionary processes (dispersals, diversifications, extinctions), which were greatly influenced by the geological and climatic ... [more ▼]

The diversity of the Antarctic marine fauna has been shaped by various evolutionary processes (dispersals, diversifications, extinctions), which were greatly influenced by the geological and climatic history of the region. Some Antarctic lineages are descendants of Gondwanan ancestors and arose by vicariance during the progressive breakup of Gondwana, which ultimately led to the complete geographical isolation of the Antarctic continent. The Plio-Pleistocene glacial cycles have been inferred to act as a “diversity pump” on the Antarctic continental shelf. Allopatric speciation of less dispersive organisms could have resulted from the isolation of populations in ice-free refugia during the glacial advances. These glacial cycles were often suggested to have influenced the diversification of numerous complexes of closely related and morphologically very similar Antarctic species. The continuous discovery of such (pseudo-) cryptic species in the Southern Ocean suggests that its biodiversity is currently greatly underestimated. Such species complexes have been found in the amphipod genus Eusirus. In a preliminary phylogeny (COI and 28S) of the whole genus, some Antarctic nominal Eusirus species are composed of genetically distant clades, suggesting putative new species. In this study, we will sequence complete mitochondrial genomes, using a combination of skim sequencing and long-range PCRs of different Eusirus species, to which sequence data from nuclear (28S, ITS2) will be added. By greatly increasing character sampling as well as taxon sampling (including Antarctic and non-Antarctic species) compared to preliminary studies, we intend to reconstruct a robust phylogeny of the genus. Based on this DNA dataset and the phylogeny, we aim to (1) provide a better estimate of the actual diversity within the genus, using various DNA-based species delimitation methods (GMYC, PTP, 4 theta rule and ABDG) and; (2) provide a better understanding of their evolutionary history: where does the Antarctic clade come from? Did Eusirus species disperse in and/or out of the Antarctic shelf at any time of their evolutionary history? Were there periods of increased diversification during their evolution on the shelf and how do these relate to the geological/glacial history of the region? [less ▲]

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See detailCan reef-building corals face environmental changes through trophic plasticity?
Sturaro, Nicolas ULiege; Hsieh, Yun Li Eric; Liu, Ling-Wen et al

Poster (2019, March 13)

Most reef-building corals can derive nutrition either autotrophically or heterotrophically, which allows them to exploit diverse trophic pathways. When facing environmental changes, therefore, these ... [more ▼]

Most reef-building corals can derive nutrition either autotrophically or heterotrophically, which allows them to exploit diverse trophic pathways. When facing environmental changes, therefore, these organisms are expected to demonstrate an intrinsic ability to acclimatise through trophic plasticity. Despite the ecological importance of these corals, however, our understanding of their trophic plasticity is currently impaired by a lack of rigorous research approaches; a failure to consider the intraspecific variability of coral species and an oversimplification of the proxies for determining heterotrophic habits (e.g. corallite diameter). In order to understand how trophic plasticity may allow reef-building corals to acclimatise, this study aimed to assess the trophic plasticity of four morphologically contrasted coral species (i.e. Stylophora pistillata, Porites lutea, Isopora palifera and Psammocora profundacella). We determined the stable isotope ratios of carbon and nitrogen in the corals’ host tissues and algal symbionts and compared them in corals inhabiting areas around Taiwan that are characterised by contrasting temperatures (from high to low latitudes) and light levels (from shallow to mesophotic waters). In these areas, we evaluated interspecific and intraspecific trophic variability by estimating and comparing coral isotopic niches as a proxy for trophic niches. Our results suggest a variable degree of trophic plasticity in reef-building coral species. Trophic plasticity was important for P. lutea and P. profundacella, while it was lower for I. palifera and S. pistillata. Although trophic plasticity was low for the latter species, the results revealed no overlap of the isotopic niches for the host and symbiont from different locations, suggesting that these coral colonies are supported by different core resources. Moreover, the isotopic niche of higher-latitude coral colonies was larger than that of lower-latitude coral colonies, highlighting a certain trophic plasticity that may be related to the more variable environmental conditions in the higher latitudes. Analyses of additional species and locations will provide essential insights into the trophic plasticity of reef-building corals and how these species might adjust their nutrition in response to global environmental changes. [less ▲]

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See detailRevealing the trophic ecology of black corals through stable isotope analysis
Cabrera, Patricia M.; Terrana, Lucas; Lepoint, Gilles ULiege et al

Poster (2019, March 13)

Antipatharians, also known as black corals, are colonial organisms that show a high heterogeneity in their colony morphology and polyp sizes. This morphological diversity likely sustains varied ... [more ▼]

Antipatharians, also known as black corals, are colonial organisms that show a high heterogeneity in their colony morphology and polyp sizes. This morphological diversity likely sustains varied adaptations and various trophic strategies, such as variation in feeding behavior and diet composition. In some areas, black coral colonies are so dense that they dominate the community, forming black coral beds where different species co-occur. Although studies on the trophic ecology of black corals are few, they are considered to feed on zooplankton and a research, currently in progress, demonstrates that diverse species present different trophic niches, supporting the hypothesis that black corals differ in their trophic diversity. Here we are aiming to identify their diet and thus the potential diverse feeding strategies of black corals. For this purpose, we will study the stable isotopic composition of carbon, nitrogen and sulfur of black corals living in shallow waters of the northern limit of the Great Reef of Toliara, Madagascar. Tissues of black corals and three potential food sources (i.e. plankton, suspended particulate organic matter and benthic particulate organic matter) were sampled. Samples were collected at two sites, within the same bed, during the dry and wet seasons, in order to assess spatio-temporal variations. Further, plankton was sampled at bottom and sea surface, at night and day and categorized according to six size classes. Data generated will be analyzed using Bayesian modeling tools in R (SIAR, Stable Isotope Mixing Model and tRophicPosition) to determine the proportional contribution of food sources in the coral's diet and their trophic position. Results will reveal a new perspective on the feeding ecology of black corals, filling the numerous gaps on their trophic ecology, a knowledge that may explain how these species coexist in the same environment and that is needed to develop future conservation policies. [less ▲]

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See detailThe Impact of Fatigue on Proper Name Retrieval
Vanootighem, Valentine ULiege; Dupont, Manuel ULiege; Brédart, Serge ULiege

Poster (2019, March 09)

Forgetting people’s names in one of the most frequent memory complaints for older adults. Names have been showed to be more difficult to recall than conceptual biographical information about people such ... [more ▼]

Forgetting people’s names in one of the most frequent memory complaints for older adults. Names have been showed to be more difficult to recall than conceptual biographical information about people such as the person’s profession or nationality, or even more specific, unique, pieces of information. Given this particular vulnerability of proper name retrieval, the present study evaluated whether cognitive fatigue impacted the retrieval of people’s names more strongly than the retrieval of biographical information about people. We found that the retrieval of people's names was affected by time on task whereas the retrieval of conceptual biographical information about people's identity was not affected. This is new evidence of the particular fragility of proper name retrieval. [less ▲]

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See detailSynthesis of Ni / γ-Al2O3 catalysts by the sol-gel method for the catalytic reforming of glycerol
Solis Garcia, Hugo Fernando ULiege

Poster (2019, March 04)

Nickel supported gamma alumina catalysts have been developed for the use in glycerol reforming applications. The catalysts were developed using the sol-gel method and characterized using TPR, BET, XRD ... [more ▼]

Nickel supported gamma alumina catalysts have been developed for the use in glycerol reforming applications. The catalysts were developed using the sol-gel method and characterized using TPR, BET, XRD, TEM, and ICP techniques. The catalysts were prepared with different precursors; two nickel precursors: nickel acetate (Ni(CH COO) .2H O) and nickel nitrate (Ni(NO ) .6H O), two different alumina precursors: aluminum tri-sec-butoxide (C H AlO ) and aluminum isopropoxide Al(O-iC H ) , two funtionalized silicon precursors: EDAS ((CH O) Si(CH ) NHCH CH NH ) and AMS (H N(CH ) Si(OCH ) ), and two different solvents: 2-methoxyethanol (CH OCH CH OH) and 2 ethoxyethanol (C H OCH CH OH) in order to determine the texture, morphology and crystallographic properties of each catalysis and select the best preparation route. Only the formation of γ-Al O is aimed in order to use these alumina materials catalytic supports because of it present high specific surface area and pore volume values. So it was developed a synthesis sol-gel procedure for the cogelation between the funtionalized silicon precursors and alumina precursors. For this purpose, a certain weight percent of Ni salt was added to a solvent and a silicon precursor with continuous stirring. Then, a certain amount of alumina precursor and additionally another solution of solvent and water were added. The sample was dried at 80 °C and atmospheric pressure for 3 days, after that, using a controlled ramp, the pressure decreased to 10 mbar for 3 days and the temperature was increased to 150 °C. The samples were calcined at two different temperatures (550°C and 900°C) for 8 h. Finally, the catalysts were reduced at reduction temperature of 350°C for approximately 2-3 h. Hydrogen was utilized as a reducing gas at a flow rate of 60 mL/min. From the results obtained, it was observed that the catalysts prepared with nickel acetate, 2-methoxyethanol and EDAS present a great stability in their structure, the presence of γ-Al2O3 was confirmed by XRD analysis, Ni metal particles doped in gamma alumina were noted using TEM analysis. The calculation of the crystal size using the Scherrer equation determined average particle sizes between 8-40 nm depending on the Ni concentration of the catalyst. According to the BET analysis, it was determined that samples present TYPE I & II isotherms, and microporous & mesoporous solids depending on the Ni concentration. The catalysts presented a BET surface area between 250-515 m /g and average pore size between 2 to 7 nm. [less ▲]

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See detailDéveloppement et validation d'une méthode de diganostique non-ciblée pour la caractérisation des fluides pulmonaires
Zanella, Delphine ULiege; Stefanuto, Pierre-Hugues ULiege; Dubois, Lena ULiege et al

Poster (2019, March)

L’amélioration constante de l’instrumentation analytique génère un intérêt croissant dans les études métabolomiques. Dans ce contexte de caractérisation de mélanges complexes, la chromatographie gazeuse ... [more ▼]

L’amélioration constante de l’instrumentation analytique génère un intérêt croissant dans les études métabolomiques. Dans ce contexte de caractérisation de mélanges complexes, la chromatographie gazeuse bidimensionnelle (GC×GC) constitue une solution efficace pour obtenir un aperçu complet de la composition des échantillons. Cependant, l’augmentation de la résolution analytique s'accompagne d'une augmentation de la complexité des données générées [1,2]. Pour garantir l'utilisation correcte de l'instrumentation analytique, l’optimisation de la méthode et l’établissement d’un protocole de contrôle qualité (QC) adéquats et clairement définis sont nécessaires. Malheureusement, peu d'études GC×GC non ciblées présentent ces aspects importants et une utilisation abusive des termes validation et semi-quantification est florissante dans les publications. Ces biais conduisent au problème général du manque de reproductibilité des études en science, souligné dans les publications récentes de Nature [3,4]. Pour résoudre ce problème, plusieurs initiatives, telles que l'initiative de normalisation en métabolomique (MSI), ont établi des directives générales pour éviter ce manque de robustesse analytique [5,6].Cette étude présente l'application et l'adaptation des directives MSI pour l'analyse de mélanges volatils à l'aide de la GC×GC-TOFMS. Pour illustrer cette approche, les profils volatils de fluide de lavage bronchoalvéolaire (BALF) ont été analysés. Cette procédure médicale est largement répandue et fournit des informations importantes sur les processus immunologiques, inflammatoires et infectieux des voies respiratoires. Tout d'abord, une solution de QC a été créée en regroupant des échantillons de BALF provenant de différents patients. Cette solution a ensuite été utilisée pour l’optimisation de la méthode, c’est-à-dire l’échantillonnage ainsi que les conditions chromatographiques. Sur base des conditions optimales, la validation a été effectuée. La solution QC a également été utilisée comme base pour la mise en œuvre d'un protocole de contrôle de qualité pour l'analyse de volatils dans les matrices biologiques. Cette étude a pour objectif de fournir des conseils pour l’établissement d’une stratégie analytique robuste pour les analyses non ciblées. References 2. Stefanuto, P. H. et al. Advanced method optimization for volatile aroma profiling of beer using two-dimensional gas chromatography time-of-flight mass spectrometry. J. Chromatogr. A 1507, 45–52 (2017). 3. Monya Baker. Seek out stronger science. Nature 537, 703–704 (2016). 5. Sumner, L. W. et al. Proposed minimum reporting standards for chemical analysis: Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI). Metabolomics 3, 211–221 (2007). [less ▲]

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See detailImportance du type d'absorbant pour l'échantillonnage des volatils : application sur les cultures bactériennes et l'haleine
Zanella, Delphine ULiege; Franchina, Flavio ULiege; Stefanuto, Pierre-Hugues ULiege et al

Poster (2019, March)

Les composés organiques volatils bactériens (VOC) sont considérés comme des biomarqueurs sensibles et spécifiques pour le phénotypage bactérien dans les biofluides humains (haleine, sang, urine, etc.) et ... [more ▼]

Les composés organiques volatils bactériens (VOC) sont considérés comme des biomarqueurs sensibles et spécifiques pour le phénotypage bactérien dans les biofluides humains (haleine, sang, urine, etc.) et dans les milieux de culture. La possibilité d'utiliser les VOCs pour l'identification bactérienne ouvre de nouvelles possibilités pour la mise au point de techniques de diagnostiques plus efficaces. Outre les différences biologiques des environnements in-vivo et in-vitro, il est essentiel d'utiliser la même technique d’échantillonnage pour la caractérisation et la validation de biomarqueurs. Dans cette étude, la chromatographie gazeuse bidimensionnelle couplée à la spectrométrie de masse (GC×GC-MS) a été utilisée pour comparer et évaluer différents adsorbants de tubes de désorption thermique pour l’échantillonnage des VOCs. Plus précisément, les paramètres suivants ont été évalués pour chaque adsorbant: sensibilité, sélectivité, reproductibilité et linéarité. Cinq adsorbants différents (Carbopack Y, X, B, Carboxen 1000 et Tenax), utilisés individuellement ou en combinaison, ont été testés sur un mélange de standards (15 composés). Les meilleures sensibilité et reproductibilité ont été obtenues pour les tubes conditionnés avec du Tenax. Les deux tubes de désorption thermique les plus performants, Tenax et Carbopack Y + X + Carboxen 1000, ont également été évalués sur des cultures de E. coli, S. aureus et P. aeruginosa. Ces deux types de tubes ont pu distinguer les 3 types de culture bactérienne, mais une amélioration de la sensibilité et de la reproductibilité a été obtenue avec les tubes Tenax. Une comparaison similaire sur les performances des tubes a été effectuée sur des échantillons d'haleine. [less ▲]

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See detailAccelerated Microfluidic Native Chemical Ligation at Difficult Amino Acids Towards Cyclic Peptides
Toupy, Thomas ULiege; Ollivier, Nathalie; Melnyk, Oleg et al

Poster (2019, February 26)

The intramolecular SEA ligation for the preparation of cyclic peptides of various sizes was studied under microfluidic conditions. Three types of peptides, namely POL (10 residues), RTD-1 (18 residues ... [more ▼]

The intramolecular SEA ligation for the preparation of cyclic peptides of various sizes was studied under microfluidic conditions. Three types of peptides, namely POL (10 residues), RTD-1 (18 residues) and F2-K1 (28 residues) as well as specific difficult junctions were chosen as the main targets of this research. The microfluidic setup for the intramolecular SEA ligation formally telescoped two process steps. In the first microreactor, the reversible N,S-acyl shift reaction leading to a super reactive SEA thioester species (3) proceeded in ~90% conversion for all studied peptide sequences. Extremely fast cyclative ligations (< 5 min) at difficult junctions that are notoriously time-consuming were achieved accordingly in a second, telescoped microfluidic module. Efficient ligations at difficult (valine, threonine or isoleucine) and even intractable junctions (such as proline) were achieved with extremely short ligation times down to 2 min (vs 48 h under conventional conditions). Excellent conversions (60 to 96%) and overall isolated yields were obtained for the cyclization of POL and analogs (64 min total production time) and for RTD-1 and analogs (75 min total) [less ▲]

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See detailExpedient Prepararation of Active Pharmaceutical Ingredient Ketamine under Sustainable Continuous Flow Conditions
Kassin, Victor-Emmanuel ULiege; Gerardy, Romaric ULiege; Toupy, Thomas ULiege et al

Poster (2019, February 26)

According to the World Health Organization, depression has become one of the most challenging health issue. With most current antidepressant medications, weeks, if not months, are typically required for ... [more ▼]

According to the World Health Organization, depression has become one of the most challenging health issue. With most current antidepressant medications, weeks, if not months, are typically required for improving patient conditions. By contrast, ketamine (1a), is effective within the first intake. Recent Phase III clinical studies demonstrated the ability of ketamine to rapidly reduce the most severe symptoms of depression. However, current synthetic routes for the preparation of 1a require the use of toxic reagents, FDA class 1-2 solvents and are low atom economy processes. In this work, we describe an effective continuous flow procedure for the expedient and sustainable preparation of 1a and analogs. This procedure involves commercially available low-toxicity chemicals and a FDA class 3 solvent (ethanol). The continuous flow procedure (Figure 1) features 3 steps, including a unique hydroxylation step with molecular oxygen, an iminiation relying on triisopropyl borate and a thermal rearrangement catalyzed by Montmorillonite K10. Each continuousflow step can be performed individually or can be concatenated, thus providing a compact yet robust process for the manufacture of ketamine and analogs (1a-c). The scalability of the critical hydroxylation step was assessed in a commercial pilot continuous-flow reactor. [less ▲]

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See detailUse of Blood Volatiles as Trace Evidence
Dubois, Lena ULiege; Perrault, Katelynn ULiege; Stefanuto, Pierre-Hugues ULiege et al

Poster (2019, February 20)

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See detailThe secretome of skeletal muscle cells: A systematic review
Florin, Antoine ULiege; Lambert, Cécile ULiege; Sanchez, Christelle ULiege et al

Poster (2019, February 20)

This poster presents the preliminary results of a systematic review that summarized recent mass-spectrometry based proteomics discoveries of the secretome of skeletal muscle cells in response to disease ... [more ▼]

This poster presents the preliminary results of a systematic review that summarized recent mass-spectrometry based proteomics discoveries of the secretome of skeletal muscle cells in response to disease, exercise or metabolic stress. [less ▲]

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See detailSAFE JOINTS - Joints as key elements against the collapse of steel and composite structures under exceptional loadings
Corman, Adrien ULiege

Poster (2019, February 18)

Nowadays, modern design norms require to the civil engineer to design robust structures in order to limit the occurrence of failures under exceptional loadings. In steel and steel-concrete composite ... [more ▼]

Nowadays, modern design norms require to the civil engineer to design robust structures in order to limit the occurrence of failures under exceptional loadings. In steel and steel-concrete composite construction, this request for robustness mainly focusses on the joints between structural members, these joints generally being the «weak» elements of a structure. In this context, it is recommended to provide an appropriate ductility to the joints but no design recommendations are nowadays provided in the norms. The purpose of the present work therefore consists in filling that gap. [less ▲]

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See detailPOMDP-Based Risk Maintenance Planning for Offshore Wind Substructures
Morato Dominguez, Pablo Gabriel ULiege; Nielsen, Jannie S.; Rigo, Philippe ULiege

Poster (2019, February 18)

This work presents a novel methodology to identify the optimal maintenance strategy for an offshore wind structural component, providing a flexible and reliable support to decision-making and balancing ... [more ▼]

This work presents a novel methodology to identify the optimal maintenance strategy for an offshore wind structural component, providing a flexible and reliable support to decision-making and balancing inspection, repair and failure costs. The methodology is tested for a tubular joint through a 60-states POMDP, obtaining the optimal maintenance policy in low computational time and in good agreement with common Risk-Based Inspection (RBI) methods. [less ▲]

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See detailTransport heterogeneity quantification in heterogeneous fractured media - Chalk
Hoffmann, Richard ULiege; Goderniaux, Pascal; Dassargues, Alain ULiege

Poster (2019, February 18)

The realistic assessment and the quantification of heterogeneity is crucial for transport in fractured rocks. Common solute tracer tests are limited to advection, while smart tracer as dissolved gases or ... [more ▼]

The realistic assessment and the quantification of heterogeneity is crucial for transport in fractured rocks. Common solute tracer tests are limited to advection, while smart tracer as dissolved gases or heat offer new innovative process imaging possibilities for fractured media. Within the PhD program these smart tracers were injected between two adjacent boreholes (7.55 m distance) in the double porosity Chalk at Mons in Belgium. Preliminary fields result shows a diffusion induced variation between the one magnitude higher diffusive Helium and the used dye tracer Uranine. In the heat case, heat is 12.5 hours delayed compared to Uranine, due to matrix storage effects. Also, after stopping the heat injection and a temporary temperature drop down, a temperature rebound was measurable. The preliminary results motivate for further numerical modelling to get a realistic assessment of heterogeneity. [less ▲]

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See detailReliability assessment of aging miter gates in the presence of corrosion and fatigue
Dang Van Thuong, ULiege; Mai, Anh Quang ULiege; Morato Dominguez, Pablo Gabriel ULiege et al

Poster (2019, February 18)

Aging Hydraulic steel structures, especially lock gates suffer from structural deterioration with fatigue and corrosion, resulting in a reduction of their resistance. A prolonged exposure to these hazards ... [more ▼]

Aging Hydraulic steel structures, especially lock gates suffer from structural deterioration with fatigue and corrosion, resulting in a reduction of their resistance. A prolonged exposure to these hazards results in a reduction of structural resistance which can lead to failure. This research presents an approach to compute the reliability of aging miter gates in the presence of corrosion and fatigue. First order reliability index method is used to calculate reliability of the structure. An example of an aging miter gate is used for demonstration. [less ▲]

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See detailDegradation mechanisms of chlorinated solvents in groundwater - Application in fractured chalk formation
Boudjana, Youcef ULiege; Brouyère, Serge ULiege; Dassargues, Alain ULiege

Poster (2019, February 18)

At an abandoned industrial site in Belgium, groundwater quality in a chalky aquifer had been impacted by a mixture of chlorinated aliphatic hydrocarbons inducing a significant change in hydrochemistry ... [more ▼]

At an abandoned industrial site in Belgium, groundwater quality in a chalky aquifer had been impacted by a mixture of chlorinated aliphatic hydrocarbons inducing a significant change in hydrochemistry.Based on this case study, the aim of the thesis is to study transport and attenuation mechanisms of chlorinated solvents in the subsurface, considering their effects on the chemistry of the groundwater. The first part is devoted to analyze and interpret the collected data on the contaminated site. It allows to improve our understanding of the processes governing the reactive transport and especially the degradation of aliphatic organochlorines as observed on the site. The influence on the hydrochemistry of groundwater in the vicinity of the study area is studied. In a second part of the research, the use of a numerical model simulating groundwater flow and reactive transport for chlorinated solvents will improve our understanding and clarify the main attenuation mechanisms and their impact on the groundwater chemical composition. [less ▲]

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See detailiMAX nerve excitability study in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy
Puma, A; Benoit, J; Grecu, N et al

Poster (2019, February 08)

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See detailA new insight into β-lactam resistance in enterococci
Raymackers, Alice ULiege; Verlaine, Olivier ULiege; Amoroso, Ana Maria ULiege et al

Poster (2019, February 07)

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See detailZinc excess and the cell cycle control in Arabidopsis sp.
Thiébaut, Noémie ULiege; Zarattini, Marco; Verbruggen, Nathalie et al

Poster (2019, February 07)

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See detailCharacterization of fermentation pathways and their interaction with photosynthesis in different microalgae
Gain, Gwenaëlle ULiege; Berne, Nicolas; Remacle, Claire ULiege et al

Poster (2019, February 07)

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See detailCharakterisierung der Fluiddynamik und des Stofftransports von wässrigen Zweiphasensystemen (ATPS) in einer flüssig-flüssig Gegenstromextraktionskolonne
Meyer, Christian; Schmidt, Markus; Eggert, Armin et al

Poster (2019, February 07)

Wässrige Zweiphasensysteme (ATPS) werden z.B. durch die Lösung eines hydrophilen Polymers und eines Salzes in Wasser gebildet. Sie bieten im Gegensatz zu organisch-wässrigen Systemen schonende ... [more ▼]

Wässrige Zweiphasensysteme (ATPS) werden z.B. durch die Lösung eines hydrophilen Polymers und eines Salzes in Wasser gebildet. Sie bieten im Gegensatz zu organisch-wässrigen Systemen schonende Umgebungsbedingungen für die Extraktion von Proteinen. [1] Dennoch geht der Einsatz von ATPS selten über die Anwendung im Labor hinaus. Dies liegt zum einen am Aufwand ein passendes Extraktionssystem auszuwählen, zum anderen an den hohen Anforderungen an die apparative Umsetzung aufgrund ihrer extremen physikalischen Eigenschaften wie geringe Dichtedifferenz und Grenzflächenspannung. [2] Zur Überprüfung der technischen Umsetzbarkeit im kontinuierlichen Betrieb wurden flüssig-flüssig Extraktionsversuche in einer vollständig temperierten DN32 Extraktionskolonne mit gerührten Einbauten durchgeführt. Ausgewählt wurde ein Stoffsystem mit Polyethylenglykol und Phosphat als Phasenbildner und Albumin als Übergangskomponente, für das zunächst die Mischungslücke in Abhängigkeit des pH-Werts und der Verteilungskoeffizient bestimmt wurden. Das ATPS wurde anschließend in der Kolonne hinsichtlich der Fluiddynamik und des Stoffaustauschs untersucht. Die Einflüsse der Flüssigkeitsbelastung, des Volumenstromverhältnisses und der Rührerdrehzahl auf die Betriebsgrenze und die Trennleistung, wurden vermessen und werden im Rahmen des Posters präsentiert. Der kontinuierliche Betrieb von ATPS in einer Gegenstromextraktionskolonne wurde erfolgreich realisiert und bei einer aktiven Höhe von 1575 mm bereits mehr als 2 theoretische Trennstufen erreicht. [1] Albertsson, P.-Å., 1986: Partition of cell particles and macromolecules (3. ed.). New York. Wiley [2] Rosa, P. A. J. et al., 2010: Aqueous two-phase systems: A viable platform in the manufacturing of biopharmaceuticals. J Chromatogr A, 1217 (16), 2296–2305 [less ▲]

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See detailArabidopside interactions with plant membranes
Genva, Manon ULiege; Deleu, Magali ULiege; Andersson, Mats X. et al

Poster (2019, February 04)

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See detailNew essential oils with interesting biological activities from endemic plants of Côte d'Ivoire: Zanthoxylum mezoneurispinosum and Zanthoxylum psammophilum
Tanoh, Amenan Evelyne ULiege; Nea, Fatimata ULiege; Kenne Kemene, Tierry ULiege et al

Poster (2019, February 04)

New essential oils with interesting biological activities from endemic plants of Côte d’Ivoire: Zanthoxylum mezoneurispinosum (Ake Assi) and Zanthoxylum psammophilum (Ake Assi). Evelyne A. Tanoh1 ... [more ▼]

New essential oils with interesting biological activities from endemic plants of Côte d’Ivoire: Zanthoxylum mezoneurispinosum (Ake Assi) and Zanthoxylum psammophilum (Ake Assi). Evelyne A. Tanoh1*, Fatimata Nea1, Tierry K. Kenne2, Manon Genva2, Matthew Saive2, Felix Z. Tonzibo1, Marie-Laure Fauconnier2. 1 Laboratory of Biological Organic Chemistry, UFR-SSMT, University Felix Houphouet-Boigny, BPV 34 Abidjan, Côte d’Ivoire 2 Laboratory of Natural Molecules Chemistry, University of Liège, Gembloux Agro- Bio Tech, 2, Passage of Deportés, B-5030 Gembloux, Belgium According to OMS nearly 80% of the population depend on traditional medicine given the strong growth in the use of natural products from plants1. Many Rutaceae plants are already used in traditional medicine for their biological properties such as anticancer and antioxidant activities. Zanthoxylum mezoneurispinosum (Ake Assi) and Zanthoxylum psammophylum (Ake Assi) are endemic Rutaceae to Côte d’Ivoire. In order to determine if those plants could be used in medicine, the aim of this work was to evaluate the chemical composition and the biological activities of essential oils extracted from both plants. Essential oils of our plants isolated from the leaves, trunk bark and roots. Their chemical compositions were determined by GC-MS. In vitro biological properties were determined using two activities: Antioxidant and anti-inflammatory. The analysis of the essential oils of leaves, trunk bark and roots of Z. psammophylum exhibit the predominance of two unusual methyl ketones, 2-undecanone and 2-tridecanone in leaves and trunk bark. These compounds have biological properties according to the literature2. The root is rich in thymol. Z. mezoneurispinosum oil is rich in alpha pinene for leaves and trunk bark, while the root is rich in gamma-elemene and cyclosativene. Cyclosativene is known for its biological activities3. The essential oils of both plants showed in increasing order antioxidant value in the leaves, trunk bark and roots. A measure of anti-inflammatory activity was found to in decreasing order in the root, followed by leaves and trunk bark. These plants could constitute a source of active molecules for traditional medicine in Côte d'Ivoire. However, although these plants are endemic in this country, they are not abundant and it is necessary to limit and protect the distribution of nurseries to produce plants and reintroduce these species into their natural habitat. References 1- O.M.S, 2002. : Besoins et potentiel. N° 4. 6 p. 2- Saini Mukesh and al, (2014). J. Agric. Food. Chem, 62: 4342 – 4348. 3- Kang Min-Seung, Lee Hoi-Seon, (2018). Applied Biological chemistry 61 (6): pp 653 – 659. [less ▲]

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See detailDevelopment of a generic aquaponic model using object oriented programming to study the systems at the individuals level
Stalport, Benoît ULiege; Raulier, Pierre ULiege; De Cock, Nicolas ULiege et al

Poster (2019, February 04)

Aquaponics is the association of fish and plant farming, exploiting the natural phenomenon observed in aquatic ecosystems. The microbiota transforms the fish waste into different chemical forms that are ... [more ▼]

Aquaponics is the association of fish and plant farming, exploiting the natural phenomenon observed in aquatic ecosystems. The microbiota transforms the fish waste into different chemical forms that are less toxic for fish and very suited for hydroponic plants culture. Due to its recent and quick development, aquaponics can now be found in a variety of areas of interest such as personal installations, education fields, private and public research projects and reached nowadays the food production at medium and large scales industries. The diversity found in these installations makes it difficult to identify the mechanisms that rule aquaponics and to generalize the findings to other systems. Few researches established the equations that govern the behaviour of one particular system, in order to estimate the productions and to apply sensitivity analysis. These models often satisfy the goals of the developers but cannot be applied to different system setups. In this context, a generalist model is being developed for aquaponics. The equations are based on aquaculture, hydroponics and aquaponics researches and are implemented using an object-oriented programming in order to generate a completely generic model. The European Smart Aquaponics Project provides numerous systems with different architectures. All these installations are equipped with a full set of aquaponics sensors to generate a strong aquaponic database that will be used for model development. The computed outputs are various and new ones are regularly added to keep pace with the continuous development of aquaponics. In this case study, the model has been applied to an experimental setup to illustrate the basic calculated parameters such as the dynamical behaviours of the water volumes and several nutrient concentrations, the vegetal and animal biomasses, the water consumption, a few economic criteria, etc. [less ▲]

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See detailDevelopment of an essential oil-based new tool for pest-management in orchards : research methodology
Werrie, Pierre-Yves ULiege; Jean Le Goff, Guillaume; Hance, Thierry et al

Poster (2019, February 04)

The rosy apple aphid (Disaphys plantaginea) and the pear psylla (Cacopsylla pyri) are responsible for large yield decreases in both apple and pear orchads through sap sucking and desease spreading. To ... [more ▼]

The rosy apple aphid (Disaphys plantaginea) and the pear psylla (Cacopsylla pyri) are responsible for large yield decreases in both apple and pear orchads through sap sucking and desease spreading. To manage them, farmers use a range of phytosanitary products, that are sometimes very damaging to the environment/health. TREE INJECTION aims to propose an alternative technique based on an essential oil formulation that will be injected directly in the tree vascular system. Essential oils are natural insecticides developed by some plants through evolution, by injecting them directly in the tree, we hope to increase their persistence and avoid negative impact in the environment. The first objective is to select the essential oil (or the blend) presenting the strongest insecticidal and/or harmful properties (antifeedant, repellent, oviposition deterent) by rearing insects on artificial diets. Secondly, the possible phytotoxicity of these essential oils on trees will then be evaluated along with their translocation and impact within the plant. This will be monitored by designing a Gas-chromatography-mass spectrometry method to detect essential oil components within different organs of the tree (leaves, fruits) as well as phloem and xylem saps. Thirdly, the impact of formulation techniques such as micro-emulsion or other encapsulation techniques on the biodisponibility and persistence will be under investigation. Finally, the efficiency of these treatments will be evaluated under laboratory and field conditions. [less ▲]

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See detailRole of FOXM1 in mRNA decay
Mariavelle, Emeline ULiege

Poster (2019, February 01)

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See detailPhospho-Dependant Regulation Of TFIP11 Splicing Factor
Hanache, Sarah ULiege; Duchemin, Amandine ULiege; Peixoto, Paul et al

Poster (2019, February 01)

Pre-mRNA splicing is a fundamental process in mammalian gene expression contributing to protein diversity. Eukaryotic genes are alternatively spliced by the spliceosome, a large conserved machinery ... [more ▼]

Pre-mRNA splicing is a fundamental process in mammalian gene expression contributing to protein diversity. Eukaryotic genes are alternatively spliced by the spliceosome, a large conserved machinery complex comprising RNA, five small nuclear ribonucleoprotein particles (snRNPs: U1, U2, U4, U5 and U6) and around 200 proteins and splicing factors. These splicing factors are frequently phosphorylated by kinases. Such phosphorylation regulates their subcellular localization and interactions with target transcripts and protein partners, and thus regulates splicing reactions. Our lab demonstrated that the splicing factor TFIP11 controls cancer cell-cycle progression by regulating splicing of a specific subset of pre-mRNA (see A.Duchemin abstract). We and others have demonstrated that TFIP11 is highly phosphorylated. This phosphorylation might be critical for its nuclear localization, transport and/or its interaction with RNA or proteins such as DHX15. So, the present project is divided into three main goals: 1) Identification of kinases regulating phosphorylation of TFIP11 2) Identification of phospho-residues of TFIP11 and 3) Impact of phosphorylation on TFIP11 activity. Phosphoproteomic analyses have shown that at least 4 serine residues (S59, S96, S98, S210) and 2 tyrosine residues (Y162, Y722) on TFIP11 undergo phosphorylation. Interestingly, some of these potential phospho-residues are within functional TFIP11 domains including G-Patch domain, nuclear localization signal (NLS) and nuclear speckle targeting sites (NSTS) and belong to consensus sites for CK2 and Prp4K, two kinases known to regulate the activity of splicing factors. Immunofluorescence experiments demonstrated that CK2 and Prp4K colocalize with TFIP11 in the nuclear speckles. Co-immunoprecipitation experiments and/or proximity ligation assay (PLA) demonstrate that TFIP11, CK2 and Prp4K were associated in the same complex. Interestingly, we identified EFTUD2 as an interacting partner of TFIP11 and it seems that EFTUD2 coordinates the same splicing program as TFIP11. Finally, preliminary PLA data show that CK2 inhibition increases the interaction between TFIP11 and EFTUD2, suggesting that a CK2-dependent phosphorylation of TFP11 might be important to regulate its interaction with partner protein EFTUD2. Further investigations are ongoing to determine the functional role of the TFIP11-EFTUD2-CK2 complex in the regulation of the splicing program. [less ▲]

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See detailThe splicing factor TFIP11
Duchemin, Amandine ULiege

Poster (2019, February 01)

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See detailLe point sur la séroprévalence du SDRP en Wallonie
Smeets, Frédéric; Houtain, Jean-Yves; Quinet, Christian et al

Poster (2019, February)

In 2018, a PRRS monitoring program started in Belgium. In this perspective, in Wallonia, where only 6% of Belgian pigs are kept, PRRS seroprevalence was assessed on both breeding and fattening pig farms ... [more ▼]

In 2018, a PRRS monitoring program started in Belgium. In this perspective, in Wallonia, where only 6% of Belgian pigs are kept, PRRS seroprevalence was assessed on both breeding and fattening pig farms. Serum samples (n = 1786 from 585 sows and 1201 piglets and/or growing pigs) collected in 2016 were tested with Elisa Idexx PRRS X3 on a maximum of 10 breeding and/or 5 feeder pigs per farm (i.e. 106 farrow-to-feeder/finish and 203 growing/finishing farms). An individual result was considered negative if the S:P ratio was < 0.4; a herd was considered positive if at least one pig had an S:P ratio ≥ 0.4. A survey addressed to these 309 Walloon pig owners gave 121 usable answers from 75/106 sow and 46/203 pig(let) owners. Overall, in farrow-to-feeder/finish farms, the apparent herd, individual and intra-herd prevalence were respectively 35% (95% c.i.: 26-43%), 36% (95% c.i.: 33-39%) and 38% (95% c.i.: 35-41%). In growing/finishing farms, the apparent herd, individual and intra-herd prevalence were respectively 60% (95% c.i.: 53-67%), 54% (95% c.i.:51-58%) and 85% (95% c.i.: 82-88%). This study showed that approximately 2/3 of Walloon breeding farms appear to be PRRS free. The next step will be to identify risk and protective factors from the survey. In the perspective of starting a national PRRS control program, these indicative results, even though they need to be confirmed, will be helpful in making specific regional decisions. [less ▲]

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See detailContinuous Flow Synthesis of Cyclic Organic Carbonates Catalyzed by Organic Salts
Gerardy, Romaric ULiege; Estager, Julien; Debecker, Damien P. et al

Poster (2019, February)

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See detailRecent advance in the treatment of patients with disorders of consciousness: a review of transcranial direct current stimulation efficacy
Martens, Géraldine ULiege; Barra, Alice ULiege; Laureys, Steven ULiege et al

Poster (2019, February)

Severe brain injured patients with disorders of consciousness (DOC) represent a challenging population to treat. Non-invasive brain stimulation techniques, such as transcranial direct-current stimulation ... [more ▼]

Severe brain injured patients with disorders of consciousness (DOC) represent a challenging population to treat. Non-invasive brain stimulation techniques, such as transcranial direct-current stimulation (tDCS) can transiently improve the level of consciousness of DOC patients, as measured with the Coma Recovery Scale-Revised (CRS-R). However, it is still unclear which proportion of patients can benefit from it, how long the effects can last and which brain region represent the best area to target. We here reviewed tDCS-based clinical trials on DOC to shed light on these issues. Eight articles met our criteria: three articles evaluated the effects of a single stimulation session and 5 articles assessed the effects of repeated stimulation sessions. The areas targeted by the stimulation in the articles included the following regions: the left dorsolateral prefrontal cortex (left DLPFC – F3, 5 studies), the posterior parietal cortex / precuneus (Pz, one study), the primary motor cortex (M1 - C3 or C4, one study) and the frontoparietal network bilaterally (F3, F4, CP5 and CP6, one study). Left DLPFC was the most used target, both for single and repeated session studies and has showed to effectively increase patient’s responsiveness in the CRS-R compared to other stimulated regions. Repeated session studies generally show larger effect size of tDCS treatment and higher number of responders as compared to single session. Furthermore, we found that the number of responders of repeated session studies (39 out of 110 in total) is significantly higher (p=0.0125) than the number of responders of single session studies (22 out of 111 in total). From this retrospective exploration of tDCS clinical trials, it emerged that the left DLPFC seems to be the most powerful and promising target to improve behavioural responsiveness of DOC patients whereas the strength and duration of tDCS aftereffects seems to increase with the number of sessions. [less ▲]

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See detailImproving responsiveness to non-invasive brain stimulation in minimally conscious state patients: a closed-loop approach
Martens, Géraldine ULiege; Barra, Alice ULiege; Carrière, Manon ULiege et al

Poster (2019, February)

Transcranial direct current stimulation (tDCS) applied on the left dorsolateral prefrontal cortex has already been shown to efficiently promote the recovery of conscious awareness in patients with ... [more ▼]

Transcranial direct current stimulation (tDCS) applied on the left dorsolateral prefrontal cortex has already been shown to efficiently promote the recovery of conscious awareness in patients with disorders of consciousness following severe brain injury, especially those in minimally conscious state (MCS)1. However, one potential barrier to clinically respond to tDCS is accounting for the timing of the stimulation with regard to the fluctuations of vigilance that characterize this population2. Indeed, the vigilance of MCS patients has periodic average cycles of 70 minutes (range 57-80 minutes)3, potentially preventing them to be in an optimal neural state to benefit from tDCS when applied at random moments. To tackle this issue, we propose a new protocol to optimize the application of tDCS by selectively stimulating at high vigilance and low vigilance states, as measured by real-time spectral entropy (as a marker of vigilance3) and based on pre-identified individual thresholds, in a closed-loop fashion. We will conduct a clinical trial on 36 patients in MCS who will undergo a 4-hour EEG recording beforehand to set individual vigilance thresholds. The patients will then be randomized in three groups based on the moment of tDCS application: high vigilance, low vigilance and sham. These EEG-tDCS sessions will last for 6 hours with a maximum of two tDCS sessions of 20 min at 2 mA. Behavioral effects will be assessed using the Coma Recovery Scale-Revised4 at baseline, after 3 and 6 hours. The device used will be provided by Starlab and enable real-time analysis of EEG dynamics and spectral entropy as well as control of the tDCS stimulator (a customized version of Neuroelectrics’ Startsim 8). This unique and novel approach will provide new insights for the identification of tDCS responders and provide treatment options for the challenging population of patients with disorders of consciousness. [less ▲]

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See detailCarcass traits and lamb meat quality assessment of Beni G uil's PGI sheep from eastern Morocco
Belhaj, K.; Tikent, A.; Mansouri, A. et al

Poster (2019, February)

In Morocco, Breeding is one of the primordial sectors in the national economy, playing an important socio-economic role. The "ANOC" a Moroccan national association for sheep and goat breeders, has ... [more ▼]

In Morocco, Breeding is one of the primordial sectors in the national economy, playing an important socio-economic role. The "ANOC" a Moroccan national association for sheep and goat breeders, has achieved the "PGI Beni Guil Sheep". Many breeders from eastern Morocco contributed into this labialization process and an agreement between "ANOC" and the certification body “NORMACERT” has been signed to certify the labeling of meat from Beni Guil lambs. The first batch of labeled lambs was produced in 2012 [1]. The objective of this study is to determine the characteristics of the carcass and meat quality of "Beni Guil" female lambs reared in this semi-arid region (eastern plateau of Morocco), because female lambs are most available for slaughter during all the year, whereas male lambs are generally fattened and reserved for the festival of sacrifice "Aid Aladha". [less ▲]

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See detailUnveiling of a new role for DPF3 protein in cancer biology
Verrillo, Giulia ULiege; Hanache, Sarah ULiege; Duchemin, Amandine ULiege et al

Poster (2019, February)

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See detailOptimisation of a surface enhanced Raman scattering method using design of experiments and Bayesian design space modelling
Deidda, Riccardo ULiege; Avohou, Tonakpon Hermane ULiege; Kasemiire, Alice ULiege et al

Poster (2019, January 30)

Surface enhanced Raman scattering (SERS) is an alternative technique based on Raman spectroscopy, which has been increasingly applied to pharmaceutical analytical chemistry in the last decade. It consists ... [more ▼]

Surface enhanced Raman scattering (SERS) is an alternative technique based on Raman spectroscopy, which has been increasingly applied to pharmaceutical analytical chemistry in the last decade. It consists in enhancing the Raman effect by performing analyses using metallic surfaces, such as silver and gold colloids, on which the target molecules are adsorbed to be detected. It has been observed that in this way, an enhancement factor of 103-106 times can be obtained and the lack of sensibility related to conventional Raman scattering overcome [1]. Nowadays, design of experiment (DoE) is widely employed for modelling phenomena in analytical method development and optimisation, especially in the context of separation techniques. It is a structured approach that allows correlating key responses to controllable variables. Ideally, a certain number of factors may affect the critical method attributes (CMAs) of an analytical process in a negative or positive way. These factors are named critical method parameters (CMPs). DoE is employed, as a chemometric tool, to individuate CMPs and then, deeply study how they affect the process under study. To do so, CMAs are linked to CMPs by a regression model built by means of multivariate linear or partial least squares regression. Generally, the designs can be classified in two categories: screening and optimization designs. The formers are generally implemented when a high number of parameters are supposed to influence the analytical process and no much prior information is available. They result in useful tools to study the effects of both continuous and discontinuous factors. Instead, the optimisation designs are principally used to study wisely selected continuous factors [2]. The design space (DS) is defined as a multidimensional area in which the specifications given to the CMAs are met with a defined level of probability. Obviously, the larger the DS is, the more robust the method is. Its computation is achieved by several approaches, such as Monte-Carlo simulations, Bayesian methods as well as bootstrapping techniques [3]. The aim of this project was to combine and apply two potent chemometric tools such as DoE and Bayesian DS to SERS method development and optimisation. [1] Cailletaud, J., De Bleye, C., Dumont, E., Sacré, P.-Y., Netchacovitch, L., Gut, Y., Boiret, M., Ginot, Y.-M., Hubert, P., Ziemons, E., Critical review of surface-enhanced Raman spectroscopy applications in the pharmaceutical field. J. Pharm. Biomed. Anal. 147, 458-472, 2018. [2] Sahu, P.K., Ramisetti, N.R., Cecchi, T., Swain, S., Patro, C.S., Panda, J., An overview of experimental design in HPLC method development and validation, J. Pharm. Biomed. Anal. 147, 590-611, 2018. [3] Deidda, R., Orlandini, S., Hubert, P., Hubert, C., Risk-based approach for method development in pharmaceutical quality control context: A critical review. J. Pharm. Biomed. Anal. 161, 110-121, 2018. [less ▲]

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