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See detailIntegrated model of insect, fish and vegetable production
Hoc, Bertrand ULiege; Tomson, Thomas ULiege; Caparros Megido, Rudy ULiege et al

Poster (2020, December 12)

Global demand for food grow while resources including feed, water and spaces are limited To supply this demand in a context of sustainable development, new production models must be developed Integrated ... [more ▼]

Global demand for food grow while resources including feed, water and spaces are limited To supply this demand in a context of sustainable development, new production models must be developed Integrated productions of insects, fishes and vegetables maximize the use of resources and limit waste production The developed model allows local production of fishes and vegetables by insect bioconversion of many organic vegetable materials with small or no value [less ▲]

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See detailModified peptides as a novel immunotherapy for rheumatoid arthritis
Araklioti, Eleni ULiege; Herman, Ludivine; Nguyen, Ngoc Quynh Nhu et al

Poster (2020, December)

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See detailMandibular disparity of early sabertoothed felids from the Late Miocene of Spain
Chatar, Narimane ULiege; Fischer, Valentin ULiege; Siliceo, Gema et al

Poster (2020, October)

Machairodontinae is a subfamily of extinct felids that gathered much attention thanks to their iconic saber-teeth. Unfortunately, how this morphology evolved is unclear because of the patchy fossil record ... [more ▼]

Machairodontinae is a subfamily of extinct felids that gathered much attention thanks to their iconic saber-teeth. Unfortunately, how this morphology evolved is unclear because of the patchy fossil record of early machairodontines. The Batallones localities (Madrid, Spain) have the potential to shed light on this issue, as two cavities (Batallones-1 and Batallones-3) contain hundreds of fossils of the early machairodontines Machairodus aphanistus and Promegantereon ogygia from the late Miocene (MN10). Previous analyses suggested that these two cavities are not contemporaneous and that a morphological drift could be observed between the different sites; characterizing this intraspecific variability is thus important to better understand the evolution early machairodontines. To tackle this issue, we modelled 45 mandibles of Machairodus aphanistus and Promegantereon ogygia, 6 mandibles of more derived machairodontines, and 11 mandibles of extant felines in 3D using a laser surface scanner. We applied linear morphometry and 3DGM on these models to test for differences in populations and to better characterize the morphology of early machairodontines. All our analyses (PCA, PCoA, clustering, Procrustes ANOVA an PERMANOVA) converge in finding no morphological change in the mandibular shape between Batallones-1 and Batallones-3 questioning the the hypothesis of a morphological drift between the cavities. The morphospaces derived from 3DGM were compared to those obtained via linear morphometry and a Mantel test confirmed that the position of each individual was not significantly different between the two morphospaces. The morphospace occupation of Batallones species is closer to extant felines than to other machairodontines, suggesting the existence of a morphological gap between primitive and derived machairodontines. Also, we reveal that the peculiar orientation and large size of the mandibular condyle is a unique feature of Machairodontinae among Felidae. [less ▲]

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See detailPrecision of neural codes involved in storing phonological information in working memory
Bouffier, Marion ULiege; Kowialiewski, Benjamin ULiege; Attout, Lucie ULiege et al

Poster (2020, September 03)

Working memory (WM) precision is defined as the quality with which representations are stored in WM, and has to be distinguished from WM capacity, which is the quantity of information that can be ... [more ▼]

Working memory (WM) precision is defined as the quality with which representations are stored in WM, and has to be distinguished from WM capacity, which is the quantity of information that can be maintained in WM. This study is the first to assess the neural precision of WM traces for auditory-verbal information, using a functional magnetic resonance imaging (fMRI) approach. In this experiment, we asked 27 young adults to actively maintain 4-syllable nonwords during a 7-second interval. The nonwords were highly similar or dissimilar at the phonological level. Using multivariate voxel pattern analysis (MVPA), we explored the neural patterns associated with each nonword. We hypothesized that if auditory-verbal WM precision is limited, as indicated by the well-established phonological similarity effect in the WM literature, then dissimilar but not similar nonwords should be associated with distinctive neural patterns during WM, especially during the maintenance stage. Using Bayesian one sample t-tests on whole-brain classification accuracies, we observed that neural decoding of similar nonwords was at chance level, while neural decoding of dissimilar nonwords was clearly above chance during the maintenance stage. Searchlight analyses showed that the informative neural patterns were located in the dorsal language pathway known to support phonological processing. These results provide evidence for the neural basis of the phonological similarity effect in WM and the limited precision of phonological coding in WM. [less ▲]

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See detailpyActigraphy, an open-source python package for actigraphy data visualisation and analysis
Hammad, Grégory ULiege; Reyt, Mathilde ULiege; Beliy, Nikita ULiege et al

Poster (2020, September)

The pyActigraphy toolbox, an open-source python package for actigraphy data visualisation and analysis, offers functionalities to automatise data pre-processing, read large file batches and implement ... [more ▼]

The pyActigraphy toolbox, an open-source python package for actigraphy data visualisation and analysis, offers functionalities to automatise data pre-processing, read large file batches and implement various metrics and techniques for actigraphy data analysis. By developing the pyActigraphy package, we not only hope to facilitate data analysis but also foster research using actimetry and drive a community effort to improve this open-source package and develop new variables and algorithms. [less ▲]

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See detailIntérêt des prébiotiques dans les désordres métaboliques associés au surpoids et au vieillissement.
Neyrinck, Audrey M; Rodriguez, Julie; Taminiau, Bernard ULiege et al

Poster (2020, September)

Introduction: Près de 20% de personnes de plus de 60 ans sont obèses en Belgique et en France. La composition et la fonction du microbiote intestinal sont modifiées dans les désordres métaboliques liés à ... [more ▼]

Introduction: Près de 20% de personnes de plus de 60 ans sont obèses en Belgique et en France. La composition et la fonction du microbiote intestinal sont modifiées dans les désordres métaboliques liés à l'obésité et au vieillissement. L’administration de prébiotiques peut moduler la composition et le métabolisme du microbiote, et par là exercer des effets systémiques. Le but de l’étude est de déterminer si l’administration d’inuline seule ou en combinaison avec des oligosaccharides d’arabinoxylanes (AXOS) peut moduler la composition du microbiote intestinal et l’homéostasie glucidique chez des souris âgées rendues obèses grâce à un régime hyperlipidique. Méthodes : des souris C57Bl/6J âgées de 24 mois ont reçu un régime hyperlipidique (60% des calories issues des lipides) enrichi ou non en inuline seule ou en combinaison avec de l’AXOS (à raison de 7.5%) durant 8 semaines. L’analyse du microbiote (séquençage ADNr16S (région V1-V3) et PCR quantitative) a été réalisé dans les échantillons caecaux. Résultats : La supplémentation en prébiotiques a amélioré le transit intestinal des souris âgées et réduit le gain de poids corporel et de masse grasse. En outre, les deux composés ont diminué l’hyperglycémie, l’hyperinsulinémie et l’index d’insulino-résistance (HOMA-IR) induits par le régime gras. L’expression du proglucagon intestinal, précurseur du glucagon-like peptide-1 (GLP-1) a été induit (+40%) par les traitements prébiotiques. Parmi les changements spécifiques de la composition du microbiote intestinal, une diminution de l’abondance des bactéries du genre Alistipes et une augmentation du taux de bifidobactéries ont été observés après traitement aux prébiotiques. Discussion et conclusion : Outre l’amélioration du transit intestinal particulièrement intéressante à considérer dans le contexte du vieillissement, les prébiotiques ont contré certains désordres métaboliques induits par un régime obésogène chez des souris âgées. Notre étude permet de pointer le rôle potentiel de certaines bactéries reconnues pour être associées positivement ou négativement à l'obésité (Alistipes et bifidobactéries, respectivement). [less ▲]

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See detailIt's about time: resting during daytime alters attention in the aged
Reyt, Mathilde ULiege; Deantoni, Michele ULiege; Lesoinne, Alexia ULiege et al

Poster (2020, September)

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See detailFractal regulation of human motor activity and its manifestation at circadian and ultradian time scales
Hammad, Grégory ULiege; Reyt, Mathilde ULiege; Baillet, Marion ULiege et al

Poster (2020, September)

Human activity exhibits a fractal behaviour, characterised by scale-invariant patterns over time scales ranging from minutes to 24 hours. This suggests the existence of a control mechanism with feedback ... [more ▼]

Human activity exhibits a fractal behaviour, characterised by scale-invariant patterns over time scales ranging from minutes to 24 hours. This suggests the existence of a control mechanism with feedback interactions. Aging and Alzheimer’s disease, both marked by an alteration of the suprachiasmatic nucleus (SCN), the circadian pacemaker, have been associated with a reduced scale-invariant correlation. However, the impact of this reduction on ultradian or circadian activity dynamics and its comparison with in-lab circadian measures, remains unclear. Our results link fractal indices, measured with actigraphy, to in-lab circadian markers. Interestingly, fractal scaling in the circadian regime is associated with both daytime rest, interpreted as a fragmentation of sustained daytime activity, and shorter ultradian daytime activity fragmentation. These results also highlight the link between LIDS oscillations at night and scale-invariance at ultradian time scales. Overall, our analysis suggests that previously reported indices of activity dynamics occurring at various time scales might be associated with a common underlying regulation mechanism, involving the SCN. [less ▲]

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See detailBenefits of photonic structuring on perovskite solar cells using opal-like layers
Lobet, Michaël ULiege; Mayer, Alexandre; Maho, Anthony ULiege et al

Poster (2020, August 26)

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See detailWorld-wide compilation of air–sea ice CO2 flux with the enclosure method: Similar amplitudes to open-ocean measurements
Nomura, D.; Geilfus, N.-X.; Tison, J.-L. et al

Poster (2020, August 26)

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See detailCONSENSUS STATEMENT ON INTRA-ARTICULAR INJECTIONS OF PLATELET RICH PLASMA FOR THE MANAGEMENT OF KNEE OSTEOARTHRITIS
Eymard, F; Ornetti, P; Maillet, J et al

Poster (2020, August 20)

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See detailWHAT ARE THE MAIN RISK FACTORS FOR LOWER-EXTREMITY RUNNING-RELATED INJURIES? A RETROSPECTIVE SURVEY-BASED ON 3669 RESPONDENTS
SANFILIPPO, Damien ULiege; BEAUDART, Charlotte ULiege; Bornheim, Stephen ULiege et al

Poster (2020, August 20)

Objective: Many studies attempt to identify the risk factors for running-related injuries (RRI), but these are not yet well established. We aimed to investigate the risk factors of RRI. Methods: Design ... [more ▼]

Objective: Many studies attempt to identify the risk factors for running-related injuries (RRI), but these are not yet well established. We aimed to investigate the risk factors of RRI. Methods: Design: Retrospective online survey-based study among population of runners injured and noninjured. Setting: Leisure road and trail runners. Patients: Participants have to be at least 18 years old and have to practice running at least for 12 months. 3669 runners reported information which were included for statistical analysis. Assessment of risk factors: The online survey included 41 questions with 5 main categories: personal characteristics, daily lifestyle, training and running characteristics, practice of others sports activities, and prevention habits. Main outcome measurements: Occurrence of running-related injury over the last 12 months. Results: Amongst the 3669 runners, 1852 (50.5%) reported at least one injury over the last 12 months. Overuse injury were largely represented (60.6%). The variables associated with RRI which remained significant in the fully adjusted model were: previous injury (OR=1.63, IC 95%=1.42-1.47), competition running (OR=1.62, IC 95%=1.26-2.09), more than 2 h running per week (OR=1.30, IC 95%=1.03- 1.65), mileage (>20 km/week) (OR=1.25, IC 95%=1.01-1.55) and speed training (OR=1.23, IC 95%=1.06-1.48). Univariate analysis revealed other variables associated with more RRI: Trail runners (vs. road runners, p<0.001), men (vs. women, p<0.001), higher age (p<0.001), >2 running session /week (p<0.001). Conclusion: Previous injury remains the most relevant RRI risk factor according to the current study and previous data. Many training characteristics seem to be involved but still have to be confirmed in view of conflicting data in literature. Trail runners are more at risk of RRI. Further research would help to understand better RRI and to prevent them. [less ▲]

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See detailExploring achievement goals and online formative assessment effect on students’ performance in a blended-learning course in higher education
Sacre, Margault ULiege; Lafontaine, Dominique ULiege; Toczek, Marie-Christine

Poster (2020, August)

The development of blended-learning is experiencing unprecedented growth in higher education. Questions relating to their effectiveness are the subject of much scientific questioning since the factors of ... [more ▼]

The development of blended-learning is experiencing unprecedented growth in higher education. Questions relating to their effectiveness are the subject of much scientific questioning since the factors of its success are not yet clearly defined. This study, carried out in a course of mathematics applied to computer graphics, aims to explore factors exerting an effect on student performance: online formative assessment participation and achievement goals. Our sample is composed of 46 1st-year computer science students (15 females, 31 males, X=19.5 years). In line with Roediger and Karpicke (2006) work, results from multiple linear regression show a significant and positive relation between the number of quizzes taken and performance. Significant relations between performance-approach and mastery-avoidance goals towards students’ performance are highlighted. Further analyses will test the mediation role of these achievement goals on online quiz participation. A limitation of our study lies in the small sample size. [less ▲]

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See detailGameCode: Choose your Own Problem Solving Path
Liénardy, Simon ULiege; Donnet, Benoît ULiege

Poster (2020, August)

This abstract focuses on a CS2 course in which gamified homework exercises are provided to students instead of in-class exercise sessions. The course, provided to first-year Computer Science students ... [more ▼]

This abstract focuses on a CS2 course in which gamified homework exercises are provided to students instead of in-class exercise sessions. The course, provided to first-year Computer Science students, introduces a rigorous methodology to write programs using Loop Invariants, recursion, and basic data structures such as Files, Lists, Queues, and Stacks. In early 2020, the COVID-19 pandemic caused a lock-down in our country. The universities decided to fully switch to remote teaching. As the exercises sessions previously consisted of solving problems on a blackboard, we had to design in a hurry course materials that would cope with remote teaching. Instead of giving students yet another podcast in their course schedule, we gave them homework exercises, we called GameCode, that they could do at their own convenience. These exercises are inspired by GameBooks in which the reader can choose the path she takes to complete the story. With GameCode, students can choose their own solving path for each exercise. This can be related to gamification. [less ▲]

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See detailLearning Computer Programming around a CAFÉ
Liénardy, Simon ULiege

Poster (2020, August)

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See detailSwitches in brain states in memory consolidation: a computational approach
Jacquerie, Kathleen ULiege; Drion, Guillaume ULiege

Poster (2020, July 13)

Brain information processing is shaped by fluctuations in population rhythmic activities, each defining distinctive brain states. Switches in brain states, driven by neuromodulation, plays a key role in ... [more ▼]

Brain information processing is shaped by fluctuations in population rhythmic activities, each defining distinctive brain states. Switches in brain states, driven by neuromodulation, plays a key role in the sleep-wake cycle. Such transitions are known to contribute to memory; a property called sleep-dependent memory consolidation; whose mechanisms are still poorly understood. Current computational models have often focused on the role of connectivity shift to reproduce sleep-wake pattern. Such models are not appropriate to study the impact of network oscillations on synaptic plasticity, since the rhythmic switch itself relies on a disruption of the connectivity established through learning. Previous works have highlighted the role of the slow activation of T-type calcium channel in the generation of brain state switches that are robust to cellular heterogeneity, independent from network connectivity, and thus compatible with synaptic plasticity. Here, we construct a simple thalamocortical network using conductance-based models embedding this slow channel activation. This network allows cellular-induced switches in brain activity resulting in the generation of sleep-wake cycles without alteration of synaptic weights. Then, synaptic plasticity is modeled by combining; (i) spike timing- dependent plasticity (for learning during wakefulness), (ii) long-term potentiation and (iii) long-term depression (for memory selection and consolidation during sleep). Learning is quantified through an associative memory task, i.e. the ability of neurons coding for concomitant events to strongly connect together. The proposed model makes it possible to compare the evolution of synaptic wiring during di!erent tasks and explore how sleep-wake cycles can help both consolidate relevant connections and weaken irrelevant connections. [less ▲]

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See detailA Connectivity-based Psychometric Prediction Framework for Brain-behavior Relationship Studies
Wu, Jianxiao; Eickhoff, Simon; Hoffstaedter, Felix et al

Poster (2020, July 03)

Introduction. Recent availability of population-based neuroimaging datasets with extensive psychometric characterization [1][2] opens promising perspectives to investigate the relationships between ... [more ▼]

Introduction. Recent availability of population-based neuroimaging datasets with extensive psychometric characterization [1][2] opens promising perspectives to investigate the relationships between interindividual variability in brain regions’ functional connectivity (FC) and behavior. However, the multivariate nature of prediction models based on connectivity severely limits interpretations from a cognitive neuroscience perspective. To address this issue, we propose a connectivity-based psychometric prediction (CBPP) framework based on individual region’s connectivity profile. Preliminary to the development of this region-wise approach, we performed an extensive assessment of CBPP approaches based on whole-brain connectivity. Method. Fig. 1A shows the different approaches considered at each step in our implementation of whole-brain CBPP. We used preprocessed resting-state fMRI time series and 98 psychometric variables from the Human Connectome Project (HCP) [1]. The time series were grouped into parcels using the Schaefer atlas [3]. FC was computed as the correlations between the mean time series of each pair of parcels. A set of 9 confounding variables (sex, age, age2, sex*age, sex*age2 , handedness, brain size, intracranial volume, and acquisition quarter) were regressed out from the psychometric variables. Finally, the prediction performance for a psychometric variable based on whole-brain FC was evaluated by the correlation between the predicted and the true values. For parcel-wise CBPP, the procedure was similar to whole-brain CBPP, except that the initial features included only connectivity between a specific parcel and the rest of the brain. We focused on the FIX-300-parcel-Pearson-SVR combination of approaches (see Fig. 1A), which was found to be optimal for whole-brain CBPP. We illustrated two main applications to evaluate brain region-behavior relationships in a neuroscience perspective: 1) single brain region’s predictive power for different psychometric variables 2) variation of predictive power across brain regions for a single psychometric variable. Results. Fig. 1B shows the whole-brain CBPP results from all combinations of approaches, for the 20 most well predicted psychometric variables across combinations. Overall, combinations using FIX denoising and 200-parcel/300-parcel granularity achieved the best results, regardless of connectivity computation method or regression method used (except multiple linear regression). Fig. 2A illustrates the predictive power of a pair of parcels in the Broca region for 40 selected psychometric variables. Both parcels from the left and right hemispheres exhibited high predictive power in language-related measures, cognition composite scores and working memory performance. Interestingly, the right parcel showed lower predictive power for language task accuracy, but higher power for working memory abilities. These observations are consistent with brain mapping literature about the Broca region [4][5][6][7]. Fig. 2B illustrates the variation of predictive power across parcels for working memory task overall accuracy and face condition accuracy, as well as the HCP group activation map of working memory task. Both predictive power spatial maps show best performing parcels in the cingulate cortex, parietal cortex, supramarginal gyrus, lateral frontal cortex and anterior insula, while the latter also shows well performing parcels in the inferior temporal cortex and calcarine sulcus. High predictive power and high signal changes in group activation maps were both found in the anterior cingulate cortex, parietal cortex, lateral frontal cortex and anterior insula. Conclusions. We evaluated the CBPP framework using whole-brain connectivity, demonstrating the relevance of sophisticated denoising techniques and the good performance of simple regression-based algorithms. Based on this framework, we developed a parcel-wise CBPP approach optimizing both prediction performance and neurobiological validity. References 1. Van Essen, D.C., Smith, S.M., Barch, D.M., Behrens, T.E., Yacoub, E., Ugurbil, K., for the WU-Minn HCP Consortium (2013), 'The Wu-Minn Human Connectome Project: An overview', NeuroImage, vol. 80, pp. 62-79 2. Caspers, S., Moebus, S., Lux, S., Pundt, N., Schütz, H., Mühleisen, T.W., Gras, V., et al. (2014), 'Studying variability in human brain aging in a population-based German cohort – Rationale and design of 1000BRAINS', Frontiers in Aging Neuroscience, vol. 6, pp. 149 3. Schaefer, A., Kong, R., Gordon, E.M., Laumann, T.O., Zuo, X-N., Holmes, A.J., Eickhoff, S.B., Yeo, B.T.T. (2018), 'Local-global parcellation of the human cerebral cortex from intrinsic functional connectivity MRI', Cerebral Cortex, vol. 28, pp. 3095-3114 4. Binder, J.R., Frost, J.A., Hammeke, T.A., Cox, R.W., Rao, S.M., Prieto, T. (1997), 'Human brain language areas identified by functional Magnetic Resonance Imaging', Journal of Neuroscience, vol. 17, no. 1, pp. 353-362 5. McNealy, K., Mazziotta, J.C., Dapretto, M. (2006), 'Cracking the language code: Neural mechanism underlying speech parsing', Journal of Neuroscience, vol. 26, no. 29, pp. 7629-7638 6. Salmon, E., Van der Linden, M., Collette, F., Delfiore, G., Maquet, P., Degueldre, C., Luxen, A., et al. (1996), 'Regional brain activity during working memory task', Brain, vol. 119, no. 5, pp. 1617-1625 7. Smith, E.E., Jonides, J. (1999), 'Storage and executive processes in the frontal lobes', Science, vol. 283, no. 5408, pp. 1657-1661 [less ▲]

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See detailSearching for replicable associations between cortical thickness and psychometric variables in healthy adults.
Kharabian Masouleh, Shahrzad; Eickhoff, Simon; Nicolaisen-Sobesky, Eliana et al

Poster (2020, July 03)

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See detailUnfairness in RSFC-based behavioral prediction across African American & White American Samples
Li, Jingwei; Bzdok, Danielo; Holmes, Avram et al

Poster (2020, July 02)

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See detailTibial plateau levelling techniques performed following previous tibial tuberosity advancement techniques: a case series.
Serrani, Daniele; Picavet, Pierre ULiege; Marti, Juan et al

Poster (2020, July)

Tibial tuberosity advancement techniques (TTAT) are regularly used to treat cranial cruciate ligament deficiency (CCLD). Their efficacy is related to the magnitude of the cranial tibial tuberosity ... [more ▼]

Tibial tuberosity advancement techniques (TTAT) are regularly used to treat cranial cruciate ligament deficiency (CCLD). Their efficacy is related to the magnitude of the cranial tibial tuberosity advancement (TTA); it must be such as to make the resulting force applied on the tibia perpendicular to the tibial plateau. Some cases of chronic lameness following TTAT are likely caused by persistent instability when patella issues, ongoing sepsis and meniscal lesions have been dismissed. In those cases, a suboptimal cranial TTA can be suspected. The following review illustrates the use of tibial plateau levelling techniques (TPLT) to solve the problem. [less ▲]

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See detailGlobal sensitivity analysis of the EEG forward problem
Grignard, Martin ULiege; Geuzaine, Christophe ULiege; Phillips, Christophe ULiege

Poster (2020, June 24)

When carrying out an EEG experiment for source reconstruction, one has to provide both accurate geometry and electrical properties of the head tissues. Authors usually set the electrical conductivities ... [more ▼]

When carrying out an EEG experiment for source reconstruction, one has to provide both accurate geometry and electrical properties of the head tissues. Authors usually set the electrical conductivities based on values reported in the literature which have been shown to vary widely. Here we propose a method to assess the sensitivity of the EEG forward problem to those parameters using a realistic finite element (FEM) head model including white matter anisotropic tensor. The chosen sensitivity descriptor are the first and total order Sobol indices. [less ▲]

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See detailWater and agriculture in a context of climate change
Garré, Sarah ULiege

Poster (2020, June 15)

If you want to know more about the role of water used for Flemish agriculture in the context of climate change, you've come to the right place. With this interactive poster I present the importance of ... [more ▼]

If you want to know more about the role of water used for Flemish agriculture in the context of climate change, you've come to the right place. With this interactive poster I present the importance of water in agriculture for today and tomorrow. How can Flemish agriculture adapt to the consequences of a changing climate on water availability and quality? What are the challenges and especially, what are possible solutions? [less ▲]

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See detailProbing the Photosphere/Wind Connection in Hot Stars with a Long-Exposure Chandra Observation of Zeta Puppis: X-Ray and Optical Variability
Miller, N. A.; Nichols, J.; Nazé, Yaël ULiege et al

Poster (2020, June 01)

Many previous studies of ζ Puppis (O4I(n)fp) at a variety of wave bands have reported periodic variability for this star. These studies found periods ranging from less than a day up to approximately 5 ... [more ▼]

Many previous studies of ζ Puppis (O4I(n)fp) at a variety of wave bands have reported periodic variability for this star. These studies found periods ranging from less than a day up to approximately 5 days, with much recent interest centered on the variability with a period of 1.78 days. We are using time-resolved data for Zeta Puppis from the High Energy Transmission Grating/ACIS-S instrument on the Chandra spacecraft to investigate the variability of this star in the X-ray band. The X-ray data was obtained during the following three intervals: July/August 2018 (464.0 ks), January/February 2010 (74.7 ks), and July/August 2019 (274.4 ks), for a total of 813.1 ks. In this study we concentrate on the temporal behavior of broad-band X-ray spectral regions. These bands are chosen to be wide enough to achieve adequate count rates in the short time intervals required to investigate periodic signals on the time scales described above. We compare this X-ray data with nearly contemporaneous high precision optical space photometric monitoring performed by the BRITE optical satellite array (including some corroborative data from TESS) to explore connections between the star's photosphere and its strong outflowing wind. [less ▲]

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See detailNeuroimaging data from multiple sources in PRoNTo v3.0: spatiotemporal patterns of face processing
David, Isabel A.; Schrouff, Jessica ULiege; Wu, Tong et al

Poster (2020, June)

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See detailDDR1 and MT1-MMP expression are determinant for triggering BIK-mediated apoptosis by 3D type I collagen matrix in invasive basal-like breast carcinoma cells
Saby, Charles; Collin, Guillaume; Sinane, Maha et al

Poster (2020, June)

Detailed reference viewed: 87 (2 ULiège)
See detailModified peptides as a novel immunotherapy for rheumatoid arthritis
Araklioti, Eleni ULiege; Herman, Ludivine; Nguyen, Ngoc Quynh Nhu et al

Poster (2020, June)

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See detailBeyond studying genetic diversity: how can pedigree and genomic data help us assigning individuals to breeds?
Wilmot, Hélène ULiege; Bormann, Jeanne; Gengler, Nicolas ULiege

Poster (2020, June)

Determining to which breed an individual belongs is not always an unbiased choice. Definition of breeds is not always clear and takes some subjective elements into account (e.g. phenotypes or ... [more ▼]

Determining to which breed an individual belongs is not always an unbiased choice. Definition of breeds is not always clear and takes some subjective elements into account (e.g. phenotypes or administrative rules). Moreover, insufficient pedigree deepness worsens this issue. This explains the need for development of breed assignment tools and their routine use. This kind of tools supposes a known "Reference population" containing maximum genetic diversity of the breed considered. Moreover, "Candidate individuals" have to be close enough to this "Reference population" to allow correct individual assignment. Tools based on classification methods allow breed assignment and subsequently subsidy payment schemes in Wallonia (Southern Belgium) and Luxembourg. Currently, a principal component analysis (PCA) based on genotypes is used as a routine to determine if individuals belong to two local dual-purpose cattle breeds (i.e. East Belgian Red and White, Belgium, and Ösling Red Pied, Luxembourg). This analysis relies on the position of individuals on the PCA compared to those of reference individuals from different breeds (East Belgian Red and White and Ösling Red Pied but also “sister breeds” and (Red-)Holstein). However, the continuum of Red-Pied breeds in Western Europe makes it difficult to choose to which breed the animal belongs. One example is the overlapping observed on the PCA between East Belgian Red and White and Ösling Red Pied. One solution is maybe to include these animals in both herdbooks. This would allow exchange program between so closely related breeds. Furthermore, the question arises to what extent peripherical individuals, but potentially phenotypically interesting, should be included, as they could provide more diversity to the current gene pool. In these cases, the study of different parameters that inform us about inbreeding (e.g. runs of homozygosity or effective population size) and admixture within breeds or differentiation levels (e.g. fixation index) between breeds, can help to assign individuals to breeds. [less ▲]

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See detailExploration du lien entre les scores aux quiz et le succès des étudiants de l’enseignement supérieur dans un dispositif d’enseignement hybride
Sacre, Margault ULiege

Poster (2020, June)

La mise en place de dispositifs d’enseignement hybride connait un essor sans précédent dans l’enseignement supérieur à l’international. Aussi, les questions re-latives à leur efficacité font l’objet de ... [more ▼]

La mise en place de dispositifs d’enseignement hybride connait un essor sans précédent dans l’enseignement supérieur à l’international. Aussi, les questions re-latives à leur efficacité font l’objet de nombreux questionnements scientifiques puisque les déterminants du succès de l’implantation de tels dispositifs ne sont pas encore défi-nis clairement. Les évaluations formatives en ligne ont déjà montré leur efficacité con-cernant la réussite et les performances des étudiants. Dans cette optique, une question est de savoir si le simple fait de participer au quiz augmente la performance ou si ce sont les scores aux quiz qui sont liés aux performances des étudiants. Deux études, réalisées dans des contextes d’enseignement hybride, ont pour objectif d’examiner le lien entre les scores des étudiants aux quiz immédiats et leurs performances finales. Les résultats aux deux études montrent un lien significatif entre ces deux variables. Ces résultats interrogent le poids du niveau de difficulté des quiz. Dans quelle mesure ce niveau de difficulté joue-t-il un rôle dans la régulation des performances des étudiants ? Une réplication de ces études au sein d’autres disciplines de l’enseignement supérieur est recommandée. [less ▲]

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See detailPOP1-Skeletal dysplasias : description of two new families
HARVENGT, Julie ULiege; ALKAN, Serpil ULiege; Florkin, Benoît ULiege et al

Poster (2020, June)

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See detailAssessing animal welfare: Deriving individual welfare phenotypes from existing milk recording data
Franceschini, Sébastien ULiege; Leblois, Julie ULiege; Lepot, F. et al

Poster (2020, June)

Animal welfare is an increasing concern in dairy production. Consumers want an ethical production while farmers want to ensure the health of the animals. Animal welfare measurements at the herd level such ... [more ▼]

Animal welfare is an increasing concern in dairy production. Consumers want an ethical production while farmers want to ensure the health of the animals. Animal welfare measurements at the herd level such as the Welfare Quality® (WQ®) Protocol already exist but are time-consuming and costly. Moreover, assessing the overall well-being at the animal level becomes a challenge as herd measures for welfare can not be directly translated to the animal level. Two projects, active in the Walloon Region of Belgium, HappyMoo (Interreg NWE) and ScorWelCow, are trying to define individual welfare scores (IWS) and their prediction from routinely measured milk recording data, including mid-infrared spectral data representing fine milk composition. Data from WQ® Protocol and routine milk recording was collected during the same timeframe in 18 dairy farms with 1386 cows, the majority being genotyped. Two approaches to assess and to predict individual animal welfare were developed. The first approach consisted of two steps: translating the WQ® principles into IWS and predicting these from milk recording data. The variation observed in the first step while regressing WQ® animal measures on WQ® principles was considered representative of the biological variation between cows. IWS prediction Partial Least Square regression for the 4 principles of the welfare quality scores have R2 between 0.65 and 0.77. Moreover, results from this first approach showed a significant welfare assessor effect suggesting that welfare measurements were strongly human interpretation-dependent. This suggested the need for an alternative approach. The second approach directly used milk recording data such as spectral data to cluster cows in different groups, bypassing a priori definition of welfare by WQ®. Those groups were compared to results from the first approach and showed possible discrimination for herds with enhanced WQ® score ( Specificity = 1.00 but Sensitivity = 0.10) thus suggesting further unsupervised analysis. Based on this research, novel individual welfare traits could be developed allowing future genomic selection for improved welfare. [less ▲]

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See detailEtude des liens entre les troubles du langage et les troubles cognitifs dans la maladie de Parkinson
WIOT, Nathalie ULiege; PIERROT, Mathilde; KAUX, Jean-François ULiege et al

Poster (2020, May 29)

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See detailÉvaluation des effets de la prise en charge des troubles du contrôle phonologique et sémantique auprès du patient aphasique : une approche par IRM fonctionnelle
Querella, Pauline ULiege; Attout, Lucie ULiege; WIOT, Nathalie ULiege et al

Poster (2020, May 29)

INTRODUCTION: Les patients aphasiques peuvent présenter des déficits de contrôle langagier phonologique et/ou sémantique, caractérisés par des difficultés d’inhibition verbale et mémoire de travail ... [more ▼]

INTRODUCTION: Les patients aphasiques peuvent présenter des déficits de contrôle langagier phonologique et/ou sémantique, caractérisés par des difficultés d’inhibition verbale et mémoire de travail verbale. Il existe actuellement peu de prises en charge validées pour ce type de trouble. L’objectif de cette étude de cas est d’examiner la faisabilité d’une rééducation du contrôle langagier à la fois à un niveau comportemental et cérébral. MÉTHODOLOGIE: Le patient CT était âgé de 77 ans et présentait des paraphasies phonologiques et sémantiques ainsi que des intrusions verbales dans des tâches de dénomination et de rappel sériel immédiat (RSI), indiquant un déficit de contrôle langagier phonologique et sémantique. La rééducation s’est basée sur les troubles de contrôle phonologique et s’est déroulée sur 9 semaines (9x1 heure). Elle se présentait sous forme de 4 types d’exercices dans lesquels CT devait dénommer un stimulus cible tout en inhibant un distracteur phonologiquement lié et présenté de manière auditive ou visuelle. La ligne de base (LDB) consistait en une tâche de RSI de mots comprenant des items travaillés et non travaillés. Enfin, le patient, et 34 sujets contrôles, ont réalisé une tâche de contrôle phonologique et sémantique à deux reprises en IRMf, c’est-à-dire avant et après la rééducation pour CT et après un temps d’attente équivalant à la durée de la rééducation du patient pour les sujets contrôles. RÉSULTATS: Au niveau comportemental, les performances de CT s’amélioraient de manière significative pour les items travaillés de la LDB. Des progrès étaient également observés pour les items non travaillés, suggérant un transfert de l’entraînement. Une diminution des intrusions et paraphasies verbales était observée dans les tâches de dénomination et de RSI. Ces résultats n’étaient pas explicables par une récupération spontanée car les performances restaient déficitaires dans les tâches de contrôle phonologique et sémantique présentées en IRM. Au niveau cérébral, et par rapport aux sujets contrôles, CT activait davantage des régions impliquées dans le contrôle (gyrus frontal inférieur, gyrus cingulaire) et le traitement phonologique (gyrus précentral, gyrus supramarginal), et ceci spécifiquement à la fin de la rééducation. DISCUSSION: Le programme d’entraînement phonologique semble avoir amélioré en partie les capacités de contrôle langagier phonologique de CT, associé à une sollicitation accrue de régions cérébrales impliquées dans le contrôle phonologique. Ces résultats montrent qu’une rééducation du contrôle phonologique est possible, mais une rééducation plus intensive et prolongée pourrait être nécessaire pour optimiser l’efficacité de ce type de rééducation. [less ▲]

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See detailEffet du vieillissement sur l’inhibition visuelle : Exploration à travers une tâche de MCT incluant des similitudes visuelles
Kerhardy, Nolwenn; Gregoire, Coline ULiege; Fay, Séverine et al

Poster (2020, May 28)

INTRODUCTION. L’évolution de la capacité à maintenir des informations visuelles pendant un court laps de temps (i.e. en mémoire à court terme, MCT) dans le vieillissement reste complexe à étudier. Cette ... [more ▼]

INTRODUCTION. L’évolution de la capacité à maintenir des informations visuelles pendant un court laps de temps (i.e. en mémoire à court terme, MCT) dans le vieillissement reste complexe à étudier. Cette difficulté réside principalement dans ses liens étroits avec l’inhibition requise pour maintenir, stocker et discriminer des informations visuelles. En effet, l’inhibition est un processus essentiel à la régulation et à la suppression des informations visuelles qui ne sont pas utiles pour une action en cours (e.g. la conduite automobile). Cette étude visait donc à mieux comprendre les effets de l’âge sur la capacité à reconnaitre sur une courte période, des informations visuelles comme déjà rencontrées ou non lorsque celles-ci sont visuellement proches. Nous nous attendions à des performances plus faibles lorsque la proximité visuelle entre des éléments était plus élevée, et d’autant plus pour des participants âgés du fait d’un déclin des capacités d’inhibition avec l’âge. METHODE. 24 adultes jeunes (20-40 ans) et 24 adultes âgés (60-80 ans) ont réalisé une tâche de reconnaissance en MCT visuelle. Les participants ont mémorisé des séries de 4 figures. A la fin de chaque série, une figure-test était présentée et les sujets devaient décider le plus rapidement possible si elle faisait partie des 4 figures mémorisées ou non. 30 essais négatifs étaient présentés où les figures-test négatives étaient très proches de la figure-cible (-) recrutant ainsi des processus d’inhibition pour leur rejet correct. Par ailleurs, 30 essais négatifs neutres (e.g. -) et 30 essais positifs (e.g. ►- ►, items à reconnaître) étaient également présentés. Tous les participants ont aussi réalisé le STROOP afin de mesurer leurs capacités d’inhibition. RESULTATS. Une première analyse de variance portant sur les essais positifs a montré un effet significatif du groupe d’âge, les adultes âgés ayant plus de difficultés que les jeunes à reconnaître une figure comme identique à une autre. Une seconde analyse de variance portant sur les essais négatifs a montré que les essais neutres étaient mieux réussis que les essais avec inhibition : les participants arrivaient à mieux rejeter la figure-test lorsqu’elle était totalement différente de la cible (i.e. essais neutres) que lorsqu’elle en était proche (i.e. essais avec inhibition), indiquant que les similitudes visuelles ont créé des interférences en mémoire auxquelles les participants sont sensibles. Cependant, les adultes âgés n’étaient globalement pas moins performants et pas plus affectés par ces interférences que les jeunes, bien que les résultats aient mis en évidence un effet délétère de l’âge sur les capacités d’inhibition au STROOP. Par ailleurs, les capacités d’inhibition des participants étaient corrélées positivement à leurs performances aux essais positifs et aux essais négatifs avec inhibition mais pas aux essais négatifs neutres. Ainsi, dans ce protocole, les capacités d’inhibition apparaissent déterminantes pour reconnaitre des figures identiques et pour rejeter des figures proches. Les effets d’âge spécifiques aux essais positifs suggèrent l’utilisation par les participants âgés, d’une stratégie plus conservatrice que les jeunes visant à rejeter la figure lorsqu’ils ne sont pas sûrs de l’avoir rencontré. [less ▲]

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See detailJacoby-Whitehouse illusion for taxonomic and thematic associations
Demonty, Manon ULiege; Invernizzi, Sandra; Delhaye, Emma ULiege et al

Poster (2020, May 27)

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See detailPrecision of neural representations supporting auditory-verbal working memory.
Bouffier, Marion ULiege; Kowialiewski, Benjamin ULiege; Attout, Lucie ULiege et al

Poster (2020, May 27)

Working memory (WM) precision is defined as the quality with which representations are stored in WM, and has to be distinguished from WM capacity, which is the quantity of information that can be ... [more ▼]

Working memory (WM) precision is defined as the quality with which representations are stored in WM, and has to be distinguished from WM capacity, which is the quantity of information that can be maintained in WM. This study is the first to assess the neural precision of WM traces for auditory-verbal information, using a functional magnetic resonance imaging (fMRI) approach. In this experiment, we asked 27 young adults to actively maintain 4-syllable nonwords during a 7-second interval. The nonwords were highly similar or dissimilar at the phonological level. Using multivariate voxel pattern analysis (MVPA), we explored the neural patterns associated with each nonword. We hypothesized that if auditory-verbal WM precision is limited, as indicated by the well-established phonological similarity effect in the WM literature, then dissimilar but not similar nonwords should be associated with distinctive neural patterns during WM maintenance. Using Bayesian one sample t-tests on whole-brain classification accuracies, we observed that neural decoding of similar nonwords was at chance level, while neural decoding of dissimilar nonwords was clearly above chance during the maintenance stage. Searchlight analyses showed that the informative neural patterns were located in the dorsal language pathway known to support phonological processing. These results provide evidence for the neural basis of the phonological similarity effect in WM and the limited precision of phonological coding in WM. [less ▲]

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See detailRehabilitation of phonological and semantic control in aphasia: an fMRI case study
Querella, Pauline ULiege; Attout, Lucie ULiege; WIOT, Nathalie ULiege et al

Poster (2020, May 27)

Aphasic patients may suffer from phonological or semantic inhibitory control deficits which are characterized by difficulties at the level of verbal inhibition and working memory. Very few treatment ... [more ▼]

Aphasic patients may suffer from phonological or semantic inhibitory control deficits which are characterized by difficulties at the level of verbal inhibition and working memory. Very few treatment methods are available for this type of deficit. We investigated the feasibility of a phonological control treatment program in an aphasic patient, at both behavioural and neural levels. CT (77 years old) presented with aphasic symptoms characterized by verbal inhibition deficits in various language and verbal memory tasks. Phonological control was trained with a series of tasks in which CT had to name a stimulus while inhibiting a phonological distractor presented along with the target. Baseline measures were obtained via a word immediate serial task, with both trained and untrained words. CT and 34 control subjects (CS) also completed a phonological and a semantic inhibition task in an MRI scanner. At the end of the training program, CT’s performance had significantly improved, for both treated and untreated words , suggesting a transfer effect of phonological inhibitory training rather than spontaneous recovery given that CT’s performance was still impaired in semantic inhibitory tasks (as well as other phonological control tasks) A reduced number of intrusion errors and verbal paraphasias in naming and immediate serial recall tasks was further noticed. At the neural level, following training, CT showed increased activity in fronto-temporal areas associated with phonological processing and control, as compared to controls. These results highlight the specificity of treatment programs of verbal inhibition, and by extension, of verbal language control by distinguishing between phonological and semantic inhibitory processes. [less ▲]

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See detailIn the patient’s shoes : effect of immersion on psychologist students’ communication
Goosse, Manon ULiege; Willems, Sylvie ULiege

Poster (2020, May 27)

Introduction Empathy is a core competency in any health care relationship [1], [2]. In the context of psychotherapy, empathy is an important predictor of efficacy [3]. Immersive videos (IV) give the user ... [more ▼]

Introduction Empathy is a core competency in any health care relationship [1], [2]. In the context of psychotherapy, empathy is an important predictor of efficacy [3]. Immersive videos (IV) give the user the opportunity of living a story in a first person perspective [4], [5] which enhance cognitive empathy and impact attitudes toward outgroup members [6][7]. However, these conclusions are based on self-reported measures and no evidences exist regarding the IV’s impact on actual behavior. This pilot study aim to explore the impact of immersion into old-patient shoes on empathetic communication with an actual old-patient. Methodology Students in psychology were randomly assigned to an experimental (EC, N=22) or control condition (CC, N=22). In the EC, participants were immersed in the skin of an old woman confronted to ageist attitudes in context of psychological counseling, via 360° video. In the control group, the subjects received only a few instructions to improve their communication. Empathetic communication skills (5) were assessed before and after both condition through role-play with an old woman. Results Immersion enhance empathetic communication by increasing the number of open-ended questions (p=0.02) and concretizations about patient’s perspective (p=0.05). Conclusion This pilot study shows interesting results. It implies that immersion can not only enhance cognitive empathy and attitudes [6], [7], but also lead to improved communication skills. It would be interesting to replicate this study with a larger sample and to assess the sustainability of improvements over the long term. [1] J. Lecomte, “Empathie et ses effets,” Savoirs Soins Infirm., no. 321029, pp. 1–7, 2010. [2] C. Rogers, Le développement de la personne, Dunod. Paris, 1968. [3] L. Greenberg, E. R, W. JC, and B. AC, “Empathy,” Psychotherapy, vol. 38, pp. 380–4, 2001. [4] N. de la Peña et al., “Immersive journalism: Immersive virtual reality for the first-person experience of news,” Presence Teleoperators Virtual Environ., vol. 19, no. 4, pp. 291–301, 2010. [5] S. S. Sundar, J. Kang, and D. Oprean, “Being There in the Midst of the Story: How Immersive Journalism Affects Our Perceptions and Cognitions,” Cyberpsychology, Behav. Soc. Netw., vol. 20, no. 11, pp. 672–682, 2017. [6] F. Herrera, J. Bailenson, E. Weisz, E. Ogle, and J. Zak, Building long-term empathy: A large-scale comparison of traditional and virtual reality perspective-taking, vol. 13, no. 10. 2018. [7] P. Bertrand, J. Guegan, L. Robieux, C. A. McCall, and F. Zenasni, “Learning empathy through virtual reality: Multiple strategies for training empathy-related abilities using body ownership illusions in embodied virtual reality,” Front. Robot. AI, vol. 5, no. MAR, 2018. [less ▲]

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See detailInvestigation of visual and verbal inhibition in aging within a similarity-judgement task
Van Akelyen, Dylan ULiege; Gregoire, Coline ULiege; Majerus, Steve ULiege

Poster (2020, May 27)

Inhibition is a central component of executive control that allows us to focus on target stimuli and to ignore non-target stimuli. Aging has been associated with reduced inhibitory abilities, but data are ... [more ▼]

Inhibition is a central component of executive control that allows us to focus on target stimuli and to ignore non-target stimuli. Aging has been associated with reduced inhibitory abilities, but data are contradictory as regards the domain-specificity versus generality of this impairment. The aim of this study was to conduct a comprehensive assessment of inhibitory abilities in aging by focusing on visual and verbal domains (phonological and semantic modalities). A similarity judgement task was administered in all three modalities to thirty young (20-40) and thirty elderly (60-80) adults. Participants had to judge which item out of two was the most similar to two target items. In the facilitation condition, the correct test item was preactivated via a prime appearing briefly before the trial; in the inhibition condition, the prime preactivated the wrong test item which then had to be inhibited for selection of the correct test item. An inhibition score was calculated by subtracting the performance in the inhibition condition from the facilitation condition (for correct responses and reaction times) For correct responses, we observed that the inhibition score was larger in the elderly vs. young group in each of the three modalities. For response times, the inhibition score was larger in the elderly group for the visual and semantic modalities but not phonological modality, meaning that they had more difficulties to inhibit the wrongly primed item. These results confirm inhibitory impairment in healthy aging, in a manner that appears to be rather domain-general (in verbal and visual domains). [less ▲]

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See detailOn the path to understanding pacemaking of dopaminergic neurons
Jehasse, Kevin ULiege; Massotte, Laurent ULiege; Hartmann, Sébastian et al

Poster (2020, May 22)

Despite many years of investigations by many researchers, the mechanism of pacemaking of midbrain dopaminergic (DA) neurons remains unknown. Several groups found that the Ih current, which is prominent in ... [more ▼]

Despite many years of investigations by many researchers, the mechanism of pacemaking of midbrain dopaminergic (DA) neurons remains unknown. Several groups found that the Ih current, which is prominent in a majority of these neurons, enhances pacemaking in a subgroup of DA neurons, but this is not its core mechanism. We and others have been able to rule out various types of Cav channels as pacemaking generators. In our hands, NALCN channels do not seem to contribute either, because the (admittedly non-selective) blocker Gd3+ does not reliably affect pacemaking of DA neurons at 100 µM, whereas it stops fast pacemaking of reticulata GABAergic neurons (Lutas et al., 2016). Because we know that slow pacemaking of DA neurons necessitates only a very small inward current (1-6 pA) (Khaliq and Bean, 2008), we tested the hypothesis that their pacemaking is due to many membrane proteins with a very low unitary conductance. To do this, we investigated the effect of 1-(2,4-xylyl) guanidinium (XG) on their firing. This compound had been shown to block a so-called gating pore current in pathological Nav1.4 channels (Sokolov et al., 2010). In the presence of synaptic blockers (including 1 µM sulpiride), XG completely stopped the firing of DA neurons in a concentration-dependent manner (IC50 was 485 µM, Hill coefficient was 1.28), suggesting a one-to-one interaction. The effect of XG was only weakly reversible, but the firing in the partially inhibited neurons (200-600 µM) remained extremely stable after superfusion of the drug, arguing against a toxic effect. The effect of XG was similar in young and adult rat DA neurons, and was also seen in mouse DA neurons (SH and JR). Because the commercially available XG salt is poorly water-soluble, we (RV and JFL) synthesized a much more soluble salt (XG-M) which yielded the same effect (IC50 was 427 µM). XG inhibited the firing of DA neurons without affecting their conductance and without inducing a hyperpolarization, contrary to D2 agonists. In addition, in the presence of XG, DA neurons could be induced to fire with a small amount of positive current (10 to 30 pA), and their action potential properties were unaffected by the drug. Finally, XG did not affect the pacemaking of fast GABAergic pacemakers. Using pacemaker clamp (imposing in voltage clamp the waveform of spontaneous firing), we isolated a small XG-sensitive inward current which operates from ~-60 to ~-20 mV, but is not seen at more hyperpolarized potentials, arguing against a gating pore current. Molecular biology experiments (BL and KJ) also ruled out an editing of mRNAs coding for the main voltage-dependent channels of these neurons in their S4 segments (this could have been the mechanism of a « physiological » gating pore). In ion substitution experiments, we found that the XG-sensitive current is carried by Na+ and Cl- ions, but not Ca2+ or K+ ions. Given these characteristics, we recently checked whether the dopamine transporter would be involved, since it had been shown to depolarize cultured DA neurons (Ingram et al., 2002). However, we recently ruled out this hypothesis. What could be the nature of this elusive XG-sensitive current? [less ▲]

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See detailJupiter’s polar auroral bright spots as seen by Juno-UVS
Haewsantati, Kamolporn ULiege; Bonfond, Bertrand ULiege; Wannawichian, Suwicha et al

Poster (2020, May 07)

The instruments on board the NASA Juno mission provides scientists with a wealth of unprecedented details about Jupiter. In particular, the Ultraviolet Spectrograph (UVS) is dedicated to the study of ... [more ▼]

The instruments on board the NASA Juno mission provides scientists with a wealth of unprecedented details about Jupiter. In particular, the Ultraviolet Spectrograph (UVS) is dedicated to the study of Jupiter’s aurora in the 60-200 nm wavelength range. The images taken by Juno-UVS reveals for the first time a complete view of Jupiter’s aurora, including the nightside part hidden from the Earth-orbiting Hubble Space Telescope (HST). This work aims to study Jupiter’s polar aurora using images obtained from the UVS instruments. Here we present the systematic analysis of one of the most spectacular features of Jupiter’s polar-most aurora, called the bright spot. The emitted power of the bright spots ranges from a few to a hundred GWs. Within a Juno perijove, the spots reappear at almost the same positions in system III. The time interval between two consecutive brightenings is a few tens of minutes, comparable to Jupiter’s X-ray pulsation. The comparison of the time interval with X-ray observation is under the investigation. Comparing the difference perijove sequences, the system III positions of bright spots in the northern hemisphere are concentrated in a region around 175 degrees of system III longitude and 65 degrees of latitude. On the other hand, the positions of bright spot aurora the southern hemisphere are scattered all around the pole. Previous studies suggested that the bright spot could correspond to noon facing magnetospheric cusp. However and surprisingly, we have discovered that the bright spots could map to any magnetic local time, putting this interpretation into question. [less ▲]

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See detailEvaluating the resource recovery potential of fly ash deposits using electrical and electromagnetic methods
Caterina, David ULiege; Isunza Manrique, Itzel ULiege; Michel, Hadrien ULiege et al

Poster (2020, May 06)

Burning coal, or municipal solid waste, in thermal power plants and in metallurgical industries is responsible for the production of large amounts of combustion residues, which depending on their particle ... [more ▼]

Burning coal, or municipal solid waste, in thermal power plants and in metallurgical industries is responsible for the production of large amounts of combustion residues, which depending on their particle size and density, are usually referred to as fly or bottom ash. Nowadays, they represent one of the main types of industrial waste generated. Although their composition is strongly dependent on the material burned, they typically contain ferro-aluminosilicate minerals with potentially toxic trace elements and inorganic compounds that can cause environmental problems when stored in non-sanitary landfills. At the same time, they also represent an economically interesting secondary resource as they can be valorised by replacing aggregates/additives in cement or ceramics production. Surprisingly, despite the environmental and economic considerations for these materials, their geophysical properties remain largely unknown. A better understanding of their geophysical identity could enable using geophysical methods to, for example, improve the estimation of the volume and quality of recoverable resources from ash deposition sites. In this contribution, we show the results of geophysical investigations carried out in three of these sites located in Belgium. The main geophysical techniques involved are electrical resistivity tomography, time-domain induced polarization and frequency-domain electromagnetic induction. The deposits studied generally exhibit high electrical conductivity presumably due to the high hygroscopy of fly ash, the high chlorides content and the presence of ferro-aluminosilicate minerals, each of which enhancing electrical conduction mechanisms, although the effect of the first two is conditioned by the level of water saturation present. The presence of magnetite, or other ferri- or ferromagnetic materials, may explain the high magnetic susceptibility observed. Yet, while representing a relatively homogeneous type of waste, strong variations in geophysical properties were observed between and within different sites. This suggests a great influence of the ash production process, but also of the site-specific conditions. These first results argue for further field and laboratory experiments to validate the exploratory geophysical survey results and to identify the decisive influencing factors explaining the observed electrical and magnetic response. Improved insight in the geophysical signature of fly ash deposits will allow for more accurate interpretations of geophysical measurements, in its turn providing a more sound basis for guiding conventional sampling design and thereby contributing to a more reliable assessment of the value of these industrial waste landfills in terms of the secondary resources they can deliver. [less ▲]

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See detailAlternative methods to assess the effects of a realistic Persistent Organic Pollutant mixture (POP Mix) following a chronic exposure in zebrafish larvae (Danio rerio).
Guerrero Limon, Gustavo ULiege

Poster (2020, May 05)

There is a growing concern related to the so-called Persistent Organic Pollutants (POPs). These compounds originate from different sources, some of them being synthesized with specific purposes and others ... [more ▼]

There is a growing concern related to the so-called Persistent Organic Pollutants (POPs). These compounds originate from different sources, some of them being synthesized with specific purposes and others just randomly appearing as by-products (e.g. incomplete combustion). The research into POPs has shown that they have several adverse effects. Cancer, metabolic disorders, effects in the nervous system have been described amongst many other adverse health effects after POP exposure. The POPs have been generally studied as single/individual compounds, and data is scarce related to mixtures that are not uncommon in the environment and even within humans. Thus, a realistic-environmentally significant Persistent Organic Pollutant mixture (POP Mix) as found in the serum of a Scandinavian population was tested in zebrafish larvae (Danio rerio). The zebrafish has been commonly used in the toxicology field, mainly for toxicity tests where the endpoint is lethality. In this study, a set of different approaches was used to assess the effects of a POP mix exposure on zebrafish larvae after 96 hours post-fertilization. In our scope, we mainly focused in endpoints such as development of the lateral line system, malformations, etc. Our results suggest that there are no major effects on the development of the lateral line at any of the different concentrations tested. However, some other morphological traits were undergoing deficiencies during development, such as edemas (pericardial or yolk sac). Thus, we have proven that the POP mix has some deleterious effects at realistic concentrations and further analysis is required. [less ▲]

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See detailStratigrapheR: making and using lithologs in R
Devleeschouwer, Xavier; Da Silva, Anne-Christine ULiege; Boulvain, Frédéric ULiege et al

Poster (2020, May 05)

StratigrapheR is an open-source integrated stratigraphy package. It is available in the free software environment R (https://CRAN.R-project.org/package=StratigrapheR) and is designed to generate lithologs ... [more ▼]

StratigrapheR is an open-source integrated stratigraphy package. It is available in the free software environment R (https://CRAN.R-project.org/package=StratigrapheR) and is designed to generate lithologs in a semi-automated way, to process stratigraphical information, and to visualize any plot along the lithologs in the R environment. The basic graphical principle behind StratigrapheR is the incremental addition of elements to a drawing: a plot is opened, and graphical elements are successively added. This allows compartmentalisation of the drawing process, as well as the superposition of different plots for comparison. For instance a litholog of a single section can be written as a single function including all the drawing sub-functions, and be integrated in a larger plot, for instance to be correlated to other sections or to show proxy data. The StratigrapheR package is designed for efficient work, and minimum coding, while still allowing versatility. The lithological information of beds (upper and lower boundary, hardness, lithology, etc.) is converted into polygons. All polygons are drawn together using a single function, and each polygon can have its personalised symbology allowing to distinguish lithologies. A similar workflow can be used for plotting proxies while distinguishing each sample by their lithology. Vector graphics can be imported as SVG files, and precisely drawn with the lithologs to serve as symbols or complex elements. Every type of symbol is plotted by calling one single function which repeats the drawing for each occurrence of the represented feature. This illustrates that the amount of work invested to make lithologs using StratigrapheR is related to their complexity rather than their length: a long but monotonous litholog (e.g. of marl-limestone alternations) only takes a few lines of code to generate. The StratigrapheR package also provides a set of functions to deal with selected stratigraphic intervals (for instance in the [0,1[ form): they allow simplification, merging, inversion and visualisation of intervals, as well as identifying the samples included in the given intervals, and characterising the relation of the intervals with each other (overlap, neighbouring, etc.). StratigrapheR includes PDF and SVG generation of plots, of any dimension. The generated PDF can even store multiple plots in a single file (each plot on a different page) to document data processing comprehensively. [less ▲]

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See detailProductivity and temperature as drivers of seasonal and spatial variations of dissolved methane in the Southern Bight of the North Sea
Borges, Alberto ULiege; Royer, Colin ULiege; Lapeyra Martin, Jon et al

Poster (2020, May 04)

Dissolved CH4 concentrations in the Belgian coastal zone (BCZ) (North Sea) ranged between 1607 nmol L-1 near-shore and 4 nmol L-1 off-shore during field cruises in 2016, 2017, 2018 and 2019. Spatial ... [more ▼]

Dissolved CH4 concentrations in the Belgian coastal zone (BCZ) (North Sea) ranged between 1607 nmol L-1 near-shore and 4 nmol L-1 off-shore during field cruises in 2016, 2017, 2018 and 2019. Spatial variations of CH4 were related to sediment organic matter (OM) content and gassy sediments. In near-shore stations with fine sand or muddy sediments, the CH4 seasonal cycle followed water temperature, suggesting methanogenesis control by temperature in these OM rich sediments. In off-shore stations with permeable sediments, the CH4 seasonal cycle showed a yearly peak following the Chlorophyll-a spring peak, suggesting that in these OM poor sediments, methanogenesis depended on freshly produced OM delivery. The annual average CH4 emission was 126 mmol m-2 yr-1 in the most near-shore stations (~4 km from the coast) and 28 mmol m-2 yr-1 in the most off-shore stations (~23 km from the coast), 1,260 to 280 times higher than the open ocean average value (0.1 mmol m-2 yr-1). The strong control of CH4 by sediment OM content and by temperature suggests that marine coastal CH4 emissions, in particular in shallow areas, should respond to future eutrophication and warming of climate. This is supported by the comparison of CH4 concentrations at five stations obtained in March 1990 and 2016, showing a decreasing trend consistent with alleviation of eutrophication in the area. This is also supported by the response to the European heatwave of 2018 that led to record-breaking temperatures in many countries across northern and central Europe. Average seawater temperature in July was 2.5°C higher than the mean from 2004 to 2017 for same month in the BCZ. The mean dissolved CH4 concentration in surface waters in July 2018 (338 nmol L-1) was three times higher than in July 2016 (110 nmol L-1), and an extremely high dissolved CH4 concentration in surface waters (1,607 nmol L-1) was observed at one near-shore station. The high dissolved CH4 concentrations in surface waters in the BCZ in July 2018 seemed to be due to a combination of enhancement of methanogenesis and of release of CH4 from gassy sediments, both most likely related to warmer conditions. The emission of CH4 from the BCZ to the atmosphere was higher in 2018 compared to 2016 by 57% in July (599 versus 382 µmol m-2 d-1) and by 37% at annual scale (221 versus 161 µmol m-2 d-1). The European heatwave of 2018 seems to have led to a major increase of CH4 concentrations in surface waters and CH4 emissions to the atmosphere in the BCZ. [less ▲]

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See detailNaturally CO2-rich groundwater springs in Belgium evidencing complex subsurface interactions
Welkenhuysen, Kris; Defourny, Agathe ULiege; Collignon, Arnaud et al

Poster (2020, May 04)

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See detailAn antioxidant function for dimethylsulfonopropionate (DMSP) and dimethylsulfoxide (DMSO) within three different phytoplankton groups
Gypens, Nathalie; Roberty, Stéphane ULiege; Borges, Alberto ULiege et al

Poster (2020, May 04)

Dimethylsulfonopropionate (DMSP) and dimethylsulfoxide (DMSO) are two compounds involved in the carbon and sulfur cycle and are the precursors of the climate cooling gas dimethylsulfide (DMS). Despite ... [more ▼]

Dimethylsulfonopropionate (DMSP) and dimethylsulfoxide (DMSO) are two compounds involved in the carbon and sulfur cycle and are the precursors of the climate cooling gas dimethylsulfide (DMS). Despite decades of research, their role as osmoregulator, cryoprotector or antioxidant within the phytoplankton cells remains uncertain in some part. Since the antioxidant cascade system from the DMSP reported by Sunda & al. (2002), more investigation need to be conducted to confirm or accurate these interactions. This study aims to improve the knowledge about DMSP and DMSO and their hypothetic role of antioxidant on three different classes of phytoplankton (Dinophyceae – Prymnesiophyceae – diatom) and one diatom no-DMSP producer Chaetoceros sp. as negative control. Laboratory cultures were submitted to three oxidative stress to produce Reactive Oxygen Species (ROS) with (1) increasing light intensity from 100 to 600 and up to 1200 µmole/m²s for a global and natural oxidative stress; (2) using the menadone bisulfite (MSB) to generate ·O2 and (3) using 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU) to inhibit the photosystem II (PSII). The PSII activity, the Chlorophyll a concentration (Chl a), the lipidic peroxidation (LOP), the ROS production and the pigment variation were analysed after 6h of incubation and related to the evolution of the DMSP and DMSO concentrations to better understand the cellular oxidative stress and its impact on the phytoplankton cell and DMSP and DMSO production. [less ▲]

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See detailPyriproxyfen and cadmium: what effects on the growth hormonal pathway in the amphipod Gammarus pulex ?
Jaegers, Jeremy ULiege; Gismondi, Eric ULiege

Poster (2020, May)

Due to the expected climate changes, it is predicted that disease-carrying mosquitoes will expand their geographical range, resulting in increased use of larvicides (insect growth regulators or IGRs) to ... [more ▼]

Due to the expected climate changes, it is predicted that disease-carrying mosquitoes will expand their geographical range, resulting in increased use of larvicides (insect growth regulators or IGRs) to face their proliferation. Among IGRs, the pyriproxyfen (PXF) is widely used and has been shown to prevent larvae from developing into adults and thus rendering them unable to reproduce. However, because of a similar endocrine system between crustaceans and insects, PXF could also impact aquatic crustaceans. In addition, when spreading in the environment, PXF is found in a mixture with other pollutants such as metallic trace elements, which could alter its action. Consequently, the present work was devoted to analyse the PXF effects on the growth hormonal pathway of the freshwater amphipod Gammarus pulex, as well as the combined binary effects with cadmium (Cd). After 7 days of exposure, concentration of the methylfarnesoate hormone (MF) was assessed, as well as the relative transcriptional expression of the farnesoic acid O-methyltransferase (FAMeT) (enzyme limiting the MF production), the methoprene-tolerant receptor (Met), known to bind MF to activate some transcription factors, such as broad-complex (BrC). Results revealed that exposure to PXF decreased the MF concentration, although an increase of FAMeT expression was measured. Besides, Met and BrC expressions were also increased suggesting the activation of the hormonal pathway. Nonetheless, the presence of Cd seemed to suppress these effects and even to achieve to opposite effects. Indeed, Cd-PXF binary exposure caused the diminution of MF concentration as well as under-expressions of FAMeT, Met and BrC. This work confirmed that PXF single exposure could impact non-target organisms such as amphipods through changes in hormonal pathway of methylfarnesoate. Nevertheless, when PXF was mixed to Cd, opposite results were obtained, suggesting different consequences on the long-term of the amphipod growth. [less ▲]

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See detailLes discussions parent-enfant à propos du passé : un moyen de stimuler la performance en mémoire épisodique des enfants d'âge préscolaire
Léonard, Christina ULiege; Geurten, Marie ULiege; Willems, Sylvie ULiege

Poster (2020, May)

Le développement de la mémoire épisodique est bien entendu lié à la maturation cérébrale1 mais différents facteurs environnementaux semblent également jouer un rôle important – c’est le cas peut-être des ... [more ▼]

Le développement de la mémoire épisodique est bien entendu lié à la maturation cérébrale1 mais différents facteurs environnementaux semblent également jouer un rôle important – c’est le cas peut-être des discussions parent-enfant à propos du passé. Il a en effet été suggéré qu’un style de réminiscence parentale élaboratif (c.à.d., discussions fréquentes, détaillées et collaboratives à propos du passé) favorise les capacités du jeune enfant en mémoire épisodique2. Notre objectif est d’explorer, via une étude longitudinale, quels éléments du style de réminiscence des parents influencent la performance en mémoire épisodique d’enfants âgés de 3 à 5 ans (n = 57). Le style de réminiscence parentale est analysé via une discussion parent-enfant à propos d’un événement préalablement vécu (visite standardisée de l’aquarium de Liège) et les capacités de mémoire épisodique de l’enfant sont évaluées via une tâche de rappel d’histoire en immédiat (T1) et après 9 mois (T2). Ensuite, nous avons mené des analyses de régression pas-à-pas descendantes sur les capacités en mémoire épisodique des enfants. Ces analyses ont montré de meilleures performances en mémoire épisodique au T1 pour les enfants dont les parents approfondissent la discussion des éléments du passé. En outre, nos résultats indiquent que lorsque les parents situent les éléments discutés dans leur contexte temporo-spatial et utilisent un discours méta-mnésique, les enfants obtiennent après 9 mois de meilleurs scores en mémoire épisodique. Dès lors, nos résultats confirment que discuter du passé de manière plus détaillée et contextualisée ainsi qu’en commentant les performances et/ou opérations mnésiques en cours favorise la performance du jeune enfant en mémoire épisodique. De futures recherches devraient donc approfondir cette question de l’influence des réminiscences parentales sur le développement de la mémoire épisodique. Nos résultats indiquent que la question d’un développement sous-jacent des compétences métacognitives chez l’enfant par le biais des réminiscences parentales devrait être investiguée. Les techniques de prise en charge visant la mémoire épisodique du jeune enfant étant actuellement rares, ces futures études pourraient se révéler une étape essentielle à l'implémentation d'interventions de guidance parentale ciblant le style de réminiscence. 1. Casey, B. J., Tottenham, N., Liston, C. & Durston, S. (2005). Imaging the developing brain: what have we learned about cognitive development? Trends in Cognitive Sciences, 9, 104-110. doi: 10.1016/j.tics.2005.01.011 2. Langley, H. A., Coffman, J. L., & Ornstein, P. A. (2017). The socialization of children’s memory: Linking maternal conversational style to the development of children’s autobiographical and deliberate memory skills. Journal of Cognition and Development, 18, 63-86. doi: 10.1080/15248372.2015.1135800 [less ▲]

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See detailLandfill characterization by multi-method geophysical investigation: the case study of Leppe (Germany)
Debouny, Tom ULiege; Caterina, David ULiege; Isunza Manrique, Itzel ULiege et al

Poster (2020, May)

Whether environmental or economic interests are at stake, characterization of landfills is becoming a key operation. Characterization not only concerns old landfills, but also modern engineered landfills ... [more ▼]

Whether environmental or economic interests are at stake, characterization of landfills is becoming a key operation. Characterization not only concerns old landfills, but also modern engineered landfills where the assessment and monitoring of internal processes such as leachate and biogas generation is of a primary importance. Nowadays, characterization is mostly carried out by conventional invasive methods based on drilling/trenching, sampling and laboratory analyses. Although they provide direct and analytical information, their spatial coverage, or representability, remains a major drawback. In addition, they can be expensive and increase the risk of damaging contamination barriers. Therefore, non- to minimally- invasive characterization geophysical techniques emerge as a complementary option. They allow to better capture the spatial heterogeneity across a site and are more cost-effective than punctual measurements alone. Furthermore, when compared with limited ground truth data, they may provide insights into waste composition, water content or temperature. The present study highlights the added value of a multiple geophysical approach to characterize a landfill located in Engelskirchen in Germany. Leppe landfill was used as a municipal solid waste (MSW) deposit site from 1982 until the end of 2004. Since then, only ash coming from the MSW incineration is discarded, mostly on top of the previous MSW deposit. The combination of geophysical methods used in this study included electrical resistivity tomography (ERT), induced polarization (IP), multichannel analysis of surface waves (MASW) and horizontal to vertical noise spectral ratio (HVSNR). The 3D ERT and IP model allowed to identify dry zones within the waste (which may have a direct impact on biogas production) and to roughly discriminate the layer of ash from the MSW layer. Seismic velocity model provided by MASW permitted to significantly improve the delineation between the two layers. HVNSR results combined with the information provided by MASW were used to estimate the thickness of the top layer on a larger area using a bilayer hypothesis. These geophysical characterization results were validated with available ground truth data. Overall, in the present case seismic methods showed to be more suited than geoelectrical techniques for the distinction between the ash and MSW layers. [less ▲]

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See detailUsing NIRS for analysis of soil clay content
Mariage, Clémence ULiege; Genot, Valérie; Colinet, Gilles ULiege et al

Poster (2020, May)

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See detailE-Poster for the 2020 AAO Annual Session
CHARAVET, Carole ULiege

Poster (2020, May)

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See detailPhase Ib/II trial of tisotumab vedotin+/- bevacizumab, pembrolizumab, or carboplatin in recurrent or metastatic cervical cancer (innovaTV 205/ENGOT-cx8/GOG-3024)
Vergote, Ignace; Concin, Nicole; Mirza Raza, Mansoor et al

Poster (2020, May)

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See detailTofacitinib induces clinical and endoscopic remission in biologic refractory Ulcerative Colitis patients: A real-world Belgian cohort study
Cremer, Anneline; Lobaton, Triana; VIEUJEAN, Sophie ULiege et al

Poster (2020, May)

Background Tofacitinib, an oral small molecule Janus kinase inhibitor, has been approved in 2018 for the treatment of moderate to severe ulcerative colitis (UC) in Europe. We report on real-world short ... [more ▼]

Background Tofacitinib, an oral small molecule Janus kinase inhibitor, has been approved in 2018 for the treatment of moderate to severe ulcerative colitis (UC) in Europe. We report on real-world short-term efficacy and safety data from a multicenter Belgium refractory cohort of UC patients with prior exposure to both anti-TNF and vedolizumab. Methods This is an observational, national, retrospective multicenter study including all UC active patients started on tofacitinib (10 mg BID) from 25 centers in Belgium between November 2018 to August 2019. Prospectively collected data were retrospectively analyzed according intention-to-treat. Primary endpoints were clinical and endoscopic response and remission rates at weeks 8 and 16. Clinical response and remission were defined as a reduction in Modified Clinical Mayo score (rectal bleeding, stool frequency) of ≥2 and ≤1, respectively. Endoscopic response and remission were defined as a reduction in Endoscopic Mayo score of ≥1 and ≤1, respectively. Complete endoscopic remission was defined as an Endoscopic Mayo score of 0. Descriptive statistics and Wilcoxon signed rank test were calculated using Medcal 19.1. Results Demographic and baseline data of the 70 included patients are presented in Table 1. Of note is that nearly all patients were refractory to at least one anti-TNF and vedolizumab. Median follow-up was 16 weeks (IQR 13-26). Fifty-four percent (38/70) of patients required prolonged induction at 10mg BID. Clinical evaluation was available in all patients at week 8 and 49 patients at week 16, while endoscopic data were available in 52 patients and 42 at weeks 8 and 16, respectively. Clinical response and remission, and endoscopic response and remission at week 8 and 16 are presented in Figures 1 and 2. Fifty percent (21/42) of the patients under steroids at baseline could have stopped steroids at 16 weeks. Median baseline Modified Mayo score (rectal bleeding, stool frequency and endoscopy) decreased from 7 (IQR 5- 8) to 4 (IQR 2-7) after 8 weeks (n=49) (p<0.0001), and down to 2 (IQR 1-5) at week 16 (n=40) (p<0.0001). Median CRP significantly decreased from baseline (5.3 mg/l, IQR [1.9–16.8]) to 1 mg/l at week 8 (IQR 0.5-6.2) (n=49) (p=0.003). Tofacitinib was well tolerated with only 1 reported case of single dermatome herpes zoster and no case of venous thromboembolism. Conclusions Tofacitinib very effectively induced short-term clinical and endoscopic response and remission even in a refractory cohort of patients with UC in a real-world clinical setting. During this short-term follow-up, tofacitinib was well tolerated with respect to adverse events. [less ▲]

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See detailEffect of argon plasma treatment on transparent electrodes based on silver nanowire networks
Channam, Venkat Sunil Kumar ULiege; Vermeulen, Bob ULiege; Ratz, Thomas ULiege et al

Poster (2020, May)

Transparent conducting materials (TCM) play a pivotal role in many modern devices. However, the most used TCM (ITO, Indium Tin Oxide) suffers from two major drawbacks: brittleness and indium scarcity ... [more ▼]

Transparent conducting materials (TCM) play a pivotal role in many modern devices. However, the most used TCM (ITO, Indium Tin Oxide) suffers from two major drawbacks: brittleness and indium scarcity. Among emerging TCMs used as transparent electrodes, silver nanowire (AgNW) networks appear as a promising alternative to ITO, with typical sheet resistance of 10 Ohm/sq and optical transparency of 90%, combined with good mechanical flexibility. The fabrication of these electrodes often involves low-temperature processing steps and scalable methods, thus making them ideal for low-cost transparent electrodes in flexible electronic devices. The reduced sheet resistance of AgNW networks, however is usually obtained by thermal annealing of the material up to 300 °C in air. Although this treatment drastically reduces junction resistances, this high temperature is not ideal for temperature-sensitive process steps in manufacturing. Moreover, reduced thermal budgets are desired in some applications. In this work, we present an alternative approach by sintering the as-deposited AgNW networks with plasma exposure. The high energy ions from an Ar plasma interacts with the AgNW and locally sinter the AgNW together, forming a conducting path across large distances over the network. The aim of such an approach is to reach similar electrical and optical performance characteristics as in thermally-treated materials but with a significantly lower thermal budget. Plasma exposure also offers a better surface homogeneity compared to thermal annealing, which is affected by the mismatch of thermal conduction between the glass substrate and the metallic nanowires, and reduces the impact on the integrity of flexible polymer substrates. In this work, we report on a study of the effect of the plasma power and the exposure time on the morphological, electrical and optical properties of AgNW networks and we demonstrate that a fine tuning of these parameters is needed to obtain transparent electrodes with competitive characteristics. [less ▲]

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See detailVariability and target attainment of fluconazole in critically ill patients
Van Daele, Ruth; Wauters, Joost; Brüggemann, Roger J. et al

Poster (2020, April 21)

Background: Fluconazole is an antifungal drug frequently used in the intensive care unit (ICU) but few data are available regarding its exposure in this population. A subanalysis of the DALI-study raised ... [more ▼]

Background: Fluconazole is an antifungal drug frequently used in the intensive care unit (ICU) but few data are available regarding its exposure in this population. A subanalysis of the DALI-study raised some concerns considering variability in exposure and inadequate target attainment in critically ill patients. We aimed to determine fluconazole variability and target attainment at the ICU. Materials/methods: All adult, critically ill patients treated with intravenous fluconazole between May and September 2019 were included, provided that the DNR code was <2 and written informed consent was obtained. The administered dose was left at the discretion of the treating clinician. Trough samples were collected during a maximum period of 15 days. Samples were analysed using an UPLC-DAD analytic method. The intra-and intersubject variability of fluconazole trough concentrations was calculated by dividing the standard deviation by the mean*100. Moreover, the difference between the maximum and minimum fluconazole concentration within each patients was determined. For target attainment, the fAUC/MIC from clinical data amounts to 100 corresponding with trough levels >10-15 mg/L, as recommended by EUCAST and ECIL-6. The limit for toxicity was set on 50 mg/L. Results: Seventeen patients were included, resulting in 95 fluconazole trough levels. Patients had a median APACHE-II score of 18 [16-23] and administered dose of 5.1 [4.1-7.5] mg/kg/day. The median fluconazole trough level was 26.6 [19.7-35.3] mg/L. In Figure 1, fluconazole trough concentrations are depicted in function of the dose. The mean intra-and intersubject variability (CV%) were 18,4% and 34,5%, respectively. The median difference between the maximum and minimum concentration for the 14 patients with >1 measured fluconazole level, was 14,8 [6,6-18,9] mg/L. In two patients, this difference was more than 2-fold. All trough levels were >10mg/L and 85/95 (89%) samples were >15mg/L. None of the levels exceeded the upper limit of 50 mg/L. Conclusions: As shown in the DALI-study, a considerable intra-and intersubject variability in fluconazole levels was observed at the ICU. Despite this variability, all fluconazole trough levels were above the lower limit of 10 mg/L and most of them >15 mg/L. No toxic concentrations were observed. [less ▲]

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See detailCompact multichannel spectroscopic label-free biosensor platform for plant diseases Point-Of-Care Testing (POCT)
Hastanin, Juriy ULiege; Lenaerts, Cedric ULiege; Gailly, Patrick ULiege et al

Poster (2020, April 08)

The POCT technology involving low cost Lab-On-Chip label-free biosensing opens up an opportunity to drastically reduce the total cost of plant health and disease monitoring tools. The main requirement for ... [more ▼]

The POCT technology involving low cost Lab-On-Chip label-free biosensing opens up an opportunity to drastically reduce the total cost of plant health and disease monitoring tools. The main requirement for a POCT tool is that it should involve relatively inexpensive equipment ensuring a sufficiently high accuracy of the plant disease early diagnostic. The principal objective of the presented work was to develop of a cost effective tool for biosensing assay, easy to use even for unskilled user. The label-free biosensing involving an optical near-field resonance phenomenon, such as Surface Plasmon Resonance (SPR) or localized surface plasmon resonance (LSPR), appears to be an appropriate approach for the above requirements. In this paper, we present a concept of multichannel biosensing platform dedicated to POCT, as well as the first proof-of-concept experimental investigations, demonstrating its practical feasibility. The instrumental platform investigated by our research group includes both disposable multichannel biochip and spectroscopic optical readout device. The proposed approach gives access to two plasmonic detection formats on the same lab-on-chip device: SPR and LSPR biosensing. In order to implement the LSPR sensing approach, our team has developed an original microfabrication method involving gold nanoparticles (Au_NPs) synthesis by pulsed laser writing. The biochip includes both microfluidic and biosensor structures formed into a single plastic slab. [less ▲]

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See detailDOAS measurements of NO2 and H2CO at Kinshasa and Comparisons with Satellites Observations
Yombo Phaka, Rodriguez ULiege; Merlaud, Alexis; Pinardi, Gaia et al

Poster (2020, April 04)

Africa experiences a fast urban inhabitants growth, caused by the largest population boom in the world, combined with rural exodus. Many cities are heavily affected by air pollution. It is therefore ... [more ▼]

Africa experiences a fast urban inhabitants growth, caused by the largest population boom in the world, combined with rural exodus. Many cities are heavily affected by air pollution. It is therefore essential to monitor the concentrations of the various polluting species such as NO2, HCHO, O3 and aerosols, which have a direct impact on the population health. The sources of pollutant in Africa are different from those found in Europe. For example, forest fires and household cooking largely contribute to the NO2 and HCHO burdens in Central Africa. However, many large African cities, such as the City of Kinshasa, capital of the Democratic Republic of Congo, do not have atmospheric measurement instruments. In order to tackle the lack of measurements in Kinshasa, the Royal Belgian Institute of Space Aeronomy (BIRA-IASB) has, in collaboration with the University of Kinshasa (UniKin), installed an optical remote sensing instrument on the UniKin site (-4.42°S, 15.31°E). Installed in May 2017, the instrument has been in operation until today and provides data to measure the column amounts of several polluting species in the atmosphere of Kinshasa. The instrument is based on a compact AVANTES spectrometer covering the spectral range 290 - 450 nm with 0.7 nm resolution. The spectrometer is a Czerny-Turner type with an entry slit of 50 μm wide, and an array of 1200 l/mm. A 10 m long and 600 μm diameter optical fiber is connected to the spectrometer to receive the incident light beam from the sky. Measurements were mainly made by looking in a fixed direction until November 2019. Since then, a Multi-Axis geometry (MAX-DOAS) has been implemented. The measurements provided by this DOAS instrument allowed us to start studying the atmosphere of Kinshasa using the QDOAS software, which allows us to find the oblique columns of different observed species. This poster will present the instrument, the database and the procedure used to convert these oblique columns into vertical columns, using the air mass factors calculated with the radiative transfer model. We also present our first MAX-DOAS results, analyzed using the retrieval tools of the ESA FRM4DOAS project. The study of current results clearly shows the signature of polluting species such as NO2, HCHO in the atmosphere of Kinshasa. We also use simulations by the GEOS-Chem chemistry transport model to evaluate the magnitude of the emissions needed to explain the observed column amounts. These observations made in Kinshasa could contribute to the validation of satellite products and the refinement of models. We present a first comparison of Kinshasa's ground-based observations with those of the OMI and TROPOMI satellites [less ▲]

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See detailMulticentre validation of a EUCAST method for the antifungal susceptibility testing of microconidia-forming dermatophytes
Arendrup, Maiken; Jorgensen, Karin; Guinea, Jesus et al

Poster (2020, April)

Background: Terbinafine resistance is increasingly reported in Trichophyton rubrum and Trichophyton interdigitale rendering susceptibility testing important particularly in non-responding cases. We ... [more ▼]

Background: Terbinafine resistance is increasingly reported in Trichophyton rubrum and Trichophyton interdigitale rendering susceptibility testing important particularly in non-responding cases. We performed a multicentre evaluation of a recently proposed modified EUCAST method implementing medium supplemented with chloramphenicol and cycloheximide (CC) to avoid contamination. Materials/methods: A blinded panel of wild-type and squalene epoxidase (SQLE) target gene mutant T. rubrum and T. interdigitale strains were distributed to 10 European laboratories. Susceptibility to terbinafine, itraconazole, voriconazole and amorolfine) were performed according to the E.Def 9.3.1 method with and without addition of chloramphenicol and cycloheximide (final concentrations 50 mg/L and 300 mg/L, respectively). Plates were incubated at 25 °C (one laboratory used 30 °C) for 5-7 days until sufficient growth. MICs were determined visually (ignoring trailing growth for itraconazole) and spectrophotometrically with 90% and 50% endpoints yielding a total of 7,829 MICs. A. flavus ATCC 204304 and A. flavus CNM-CM1813 were included as controls. Results: 100%/96% (voriconazole) and 84%/84% (itraconazole) MIC determinations fell within the QC ranges for the two QC strains, respectively, and 96%/92% terbinafine MICs fell in a 0.25-1 mg/L 3 two-fold-dilution range suggesting a high interlaboratory reproducibility. Across the six methods, the number of terbinafine MEs varied from 2 (2.6%) to 5 (6.6%) for T. rubrum and between 0 and 2 (2.0%) for T. interdigitale (lowest for the CC-method (2.6%-4.4%/ 0-1% for T. rubrum/T. interdigitale). The difference between the modes for the wt and mutant population were ≥7 two-fold-dilutions in all cases (Table). If excluding a I121M/V237I T. rubrum mutant, and two mixed T. interdigitale strains, the number of VMEs were CC visual: T. rubrum: 1/77 (1.3%), CC spec-90%: 3/68 (4.4%) and CC spec-50%: 1/76 (1.3%), and none for T. interdigitale. The activity of voriconazole, itraconazole and amorolfine were quite uniform against T. rubrum and T. interdigitale, but unacceptably wide MIC ranges were found for the visual and spec-90% inhibition methods for itraconazole (data not shown). Conclusions: Although none of the laboratories perform dermatophyte testing at a regular basis an acceptable interlaboratory agreement and good separation between SQLE wt and mutants were found, suggesting a robust performance of the proposed method. [less ▲]

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See detailDefect assessment of Mg-doped Cu2O thin films prepared by RF magnetron sputtering
Sliti, Naama ULiege; Resende, Joao; Ratz, Thomas ULiege et al

Poster (2020, April)

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See detailLTBP3 mutation identified in a patient with a severe valvular disease
DOCAMPO MARTINEZ, Elisa ULiege; MARTIN, Marie ULiege; Marnette, JM et al

Poster (2020, March 06)

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See detailCrashworthiness of concrete structures for floating offshore wind turbines
Marquez, Lucas ULiege; Rigo, Philippe ULiege; Le Sourne, Hervé ULiege

Poster (2020, March 05)

In this methodology, both SHIP and FOWT structures are divided into different structural elements called Super-Elements, each one having a plastic collapse mechanism and whose resistance is assessed by ... [more ▼]

In this methodology, both SHIP and FOWT structures are divided into different structural elements called Super-Elements, each one having a plastic collapse mechanism and whose resistance is assessed by means of the upper bound theorem of plasticity. [less ▲]

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See detailIncreased Endoplasmic Reticulum stress specific chaperones characterise CD fibrosis epithelium tissues and participates to in vitro induction of intestinal fibroblasts differentiation
Vieujean, Sophie ULiege; Hu, Shurong; Bequet, Emeline ULiege et al

Poster (2020, March 05)

Background: Intestinal fibrosis is a complication of Crohn’s disease (CD) characterized by myofibroblasts and extracellular matrix accumulation within the submucosa and smooth muscles, leading to bowel ... [more ▼]

Background: Intestinal fibrosis is a complication of Crohn’s disease (CD) characterized by myofibroblasts and extracellular matrix accumulation within the submucosa and smooth muscles, leading to bowel strictures. No medical treatment exists to treat or reverse intestinal fibrosis leading often to surgical resection. The potential role of intestinal epithelium in the fibrotic process remains poorly defined. Methods: We performed a pilot study on ileal fibrostricturing CD surgical samples (n=5), comparing the proteome of surface epithelium isolated by laser capture microdissection in normal and fibrotic zones. Confirmation of the specific protein increases was obtained by immunohistochemistry in colonic and ileal samples of CD (n=44) compared to healthy subjects (n=40), as well as in intestinal epithelial cell line under induced Endoplasmic Reticulum (ER) stress. A model of fibroblast to myofibroblast differentiation induction was also challenged using preconditioned media of intestinal epithelial cells after a pulsed ER stress. Results: Label free proteomics revealed high ER stress in the epithelium surrounding fibrotic bowel wall, involving Anterior gradient protein 2 homolog (AGR2) and 78kDA glucose regulated protein (BiP). Confirmation of both proteins increase was obtained by immunohistochemistry. ER stress induction in intestinal epithelial cells was associated with an intracellular increase of AGR2, BiP and ER stress markers as sXPB1 and CHOP. AGR2 was also detected in the culture medium of these epithelial cells and myofibroblast differentiation was obtained using this culture medium. Conclusions: The increase of ER stress proteins observed in fibrostenosing tissues together with These preliminary evidences of fibroblast to myofibrobast differentiation obtained by paracrine action of intestinal epithelial cell preconditioned to ER stress induction, suggest a role of epithelial ER stress in Crohn’s disease intestinal fibrosis. [less ▲]

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See detailNot one model fits all: unfairness in RSFC-based prediction of behavioral data in African American
Li, Jingwei; Bzdok, Danilo; Holmes, Avram et al

Poster (2020, March 05)

While predictive models are expected to play a major role in personalized medicine approaches in the future, biases towards specific population groups have been evidenced, hence raising concerns about the ... [more ▼]

While predictive models are expected to play a major role in personalized medicine approaches in the future, biases towards specific population groups have been evidenced, hence raising concerns about the risks of unfairness of machine learning algorithms. As great hopes and intense work have been invested recently in the prediction of behavioral phenotypes based on brain resting-state functional connectivity (RSFC), we here examined potential differences in RSFC-based predictive models of behavioral data between African American (AA) and White American (WA) samples matched for the main demographic, anthropometric, behavioral and in-scanner motion variables. We used resting-fMRI data with 58 behavioral measures of 953 subjects comprising 130 African American (AA) and 724 White American (WA). For each subject, a 419 x 419 matrix summarizing connectivity of 419 brain regions was computed. Matching between AA and WA was performed at the subject level by creating 102 pairs of AA and WA subjects, matched for 6 types of variables (age, sex, intracranial volume, education, in-scanner motion and behavioral scores). We performed 10-fold nested cross-validation by randomly splitting the 102 pairs across 10 sets. The remaining 749 subjects were also divided across the 10 sets. A predictive model was built for each behavioral variable by using kernel ridge regression. All analyses focused on the 102 matched AA and WA groups. After FDR correction (q < 0.05), no significant difference was found between the matched AA and WA groups for the matching variables. Out of 58 behavioral variables, 38 showed significantly above chance prediction accuracies (based on permutation test, FDR corrected). Overall, average prediction performance for these variables was higher in the WA group than in the AA group. Furthermore, significant differences in prediction performance between the two groups were found in 35 behavioral variables (FDR corrected; q < 0.05). Our results suggest that RSFC-based prediction models of behavioral phenotype trained on the entire HCP population show different prediction performance in different subsets of the population. This suggest that one model might not fit all that, in some cases, RSFC-based predictive models might have poorer prediction accuracies for African Americans compared to matched White Americans. Future work should evaluate the factors contributing to these discrepancies and the potential consequences, as well as possible recommendations. [less ▲]

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See detailNumerical Crashworthiness Analysis of a Spar Floating Offshore Wind Turbine Impacted by a Ship (influencing parameters)
Echeverry Jaramillo, Sara ULiege; Marquez, Lucas ULiege; Rigo, Philippe ULiege et al

Poster (2020, March 05)

•New floatingwindfarms •Deeperwater •Closertotrafficlanes •Regular maintenance •Higherriskof collision

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See detailThe effect of failure criteria on risk-based inspection planning of offshore wind support structures
Hlaing, Nandar ULiege; Morato Dominguez, Pablo Gabriel ULiege; Rigo, Philippe ULiege et al

Poster (2020, March 05)

Offshore Wind Turbine (OWT) support structures are subjected to harsh deterioration mechanisms due to the combined action of wind loading, sea induced load actions and corrosive environment. Fatigue ... [more ▼]

Offshore Wind Turbine (OWT) support structures are subjected to harsh deterioration mechanisms due to the combined action of wind loading, sea induced load actions and corrosive environment. Fatigue failure becomes a key failure mode for offshore wind structures, as they experience considerable number of stress cycles (more than 10 million cycles per year). Fatigue failure can be assessed through fatigue assessment approaches. However, such assessments possess various uncertainties which may be quantified and updated through findings from in-service inspections. Since, offshore maintenance actions incur significant costs, an optimal maintenance strategy which balances the maintenance efforts against the risk of failure is desired. Based on pre-posterior decision theory, a risk-informed maintenance optimization can be performed to define the optimal maintenance strategy and support the decision maker(s). Within the risk maintenance optimization scheme, the probabilistic deterioration model is updated based on the inspection outcomes. Several fracture mechanics models have been used in the literature to estimate the deterioration of the structure containing flaws. Although, a through-thickness failure criterion is commonly used in the literature as the failure criteria, a Failure Assessment Diagram (FAD) approach has been receiving increasingly attention, as well. This investigation examines the effect of the selected fracture mechanics models and failure criteria on the optimal maintenance strategy. Moreover, the obtained maintenance strategies corresponding to different fracture mechanics models are compared for a tubular joint case study structure. [less ▲]

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See detailA Connectivity-based Psychometric Prediction Framework for Brain-behavior Relationship Studies
Wu, Jianxiao; Eickhoff, Simon; Hoffstaedter, Felix et al

Poster (2020, March 05)

The recent availability of population-based studies with standard neuroimaging measurements and extensive psychometric characterization opens promising perspectives to investigate the relationships ... [more ▼]

The recent availability of population-based studies with standard neuroimaging measurements and extensive psychometric characterization opens promising perspectives to investigate the relationships between interindividual variability in brain regions’ connectivity and behavioral phenotypes. However, the multivariate nature of the prediction model based on connectivity within a network of brain regions severely limits the interpretation of the brain-behavior patterns from a cognitive neuroscience perspective. To address this issue, we here propose a connectivity-based psychometric prediction (CBPP) framework based on individual region’s connectivity profile. Preliminary to the development of this region-wise machine learning approach, we performed an extensive assessment of the general CBPP framework based on whole-brain connectivity information. Because a systematic evaluation of different parameters was lacking from previous literature, we evaluated several approaches pertaining to the different steps of a CBPP study. We hence tested 72 different approach combinations in a cohort of over 900 healthy adults across 98 psychometric variables. Overall, our extensive evaluation combined to an innovative region-wise machine learning approach, offers a framework that optimizes both, prediction performance and neurobiological validity (and hence interpretability) to study brain-behavior relationships. [less ▲]

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See detailComparing hypnosis and virtual reality to reduce anxiety and pain before and after a cardiovascular surgery
Rousseaux, Floriane ULiege; Dardenne, Nadia ULiege; Bicego, Aminata Yasmina ULiege et al

Poster (2020, March)

Anxiety, pain and fatigue are important factors influencing the good recovery of patients after a surgery. Nowadays, non-pharmacological techniques such as hypnosis and virtual reality are used in ... [more ▼]

Anxiety, pain and fatigue are important factors influencing the good recovery of patients after a surgery. Nowadays, non-pharmacological techniques such as hypnosis and virtual reality are used in addition to pharmacological treatment to reduce these symptoms. [less ▲]

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See detailAccelerated Orthodontics
Charavet, Carole ULiege

Poster (2020, March)

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See detailValorisation des fines de briques pour l’élaboration de liants hydrauliques
Grellier, Adèle ULiege

Poster (2020, March)

Essais de valorisation de fines de briques pour l'élaboration de liants hydraulique à base de ciment et de laitier HF. Substitution en masse du ciment ou du laitier par des fines de brique. Essais de ... [more ▼]

Essais de valorisation de fines de briques pour l'élaboration de liants hydraulique à base de ciment et de laitier HF. Substitution en masse du ciment ou du laitier par des fines de brique. Essais de caractérisation chimique, minéralogique, rhéologique et mécanique. Pour la voie avec le laitier, réalisation d'un matériau alcali-activé. [less ▲]

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See detailAnalyse de l’impact d’un projet visant à promouvoir l’activité physique chez des adolescents en surpoids
Rompen, Jérôme; Lepage, Sarah; Cloes, Marc ULiege

Poster (2020, February 28)

To fight against the lack of adherence of overweight young people to the physical activity programs, a 16-week unit has been developed while ensuring that the principles of PAMIA were applied. A group of ... [more ▼]

To fight against the lack of adherence of overweight young people to the physical activity programs, a 16-week unit has been developed while ensuring that the principles of PAMIA were applied. A group of 14 adolescents participated (8 girls). At the end of the unit, significant improvements were observed in the aerobic capacity and knowledge (p <.004). No significant effect has been demonstrated on body composition as well as on the rate of PA practice determined by questionnaire, although that 9 out of 14 subjects declared in the interviews that they were encouraged to practice more PA. Adherence to the program was high, suggesting the value of building on the PAMIA principles and to exploit this approach with other audiences. [less ▲]

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See detailAvis des étudiants et du formateur quant au respect des principes PAMIA lors d’un cycle de gymnastique associé à un carnet de suivi de cours
Theunissen, Catherine ULiege; Westenbohm, Sarah; Cloes, Marc ULiege

Poster (2020, February 28)

As part of their higher education programme in physical education, 26 students followed a gymnastics unit during which they were invited to use a course logbook developed in a way to apply the ... [more ▼]

As part of their higher education programme in physical education, 26 students followed a gymnastics unit during which they were invited to use a course logbook developed in a way to apply the PAMIAprinciples. This study aims to determine how the various concerned actors perceived their application over the course of the lessons. The students are more positive than the educator about the respect of these principles during the sessions. They offered concrete elements to be integrated to further increase their motivation and requested similar approach in other disciplines. [less ▲]

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See detailSentiment d’évolution sportive et niveau de satisfaction des étudiants sportifs de l’Université de Liège par rapport aux ressources mises à leur disposition
Berhin, Aurore ULiege; Cloes, Marc ULiege; Bonni, Jérémy ULiege

Poster (2020, February 28)

La difficulté de combiner sport et études supérieures a été bien mise en évidence dans la littérature (Breithecker, 2018 ; Gomez et al., 2018). À l’ULiège, les autorités académiques ont mis en place une ... [more ▼]

La difficulté de combiner sport et études supérieures a été bien mise en évidence dans la littérature (Breithecker, 2018 ; Gomez et al., 2018). À l’ULiège, les autorités académiques ont mis en place une structure chargée de les épauler dans leur double carrière. L’objectif de cette communication consiste à analyser leur sentiment d’évolution sportive pendant une année universitaire et de déterminer si celui-ci est corrélé avec le sentiment d’aide apporté par les aménagements mis en place dans le cadre du statut. À la fin de chaque année académique, les étudiants ayant bénéficié du statut sont invités à répondre à un questionnaire en ligne. Il a comporté de 8 à 13 thématiques. Dans cette communication nous nous centrons spécifiquement sur les réponses à une question fermée (échelle de Lickert à cinq niveaux) portant sur le sentiment d’évolution sportive des étudiants au cours de leur année universitaire. Elles pourront également être croisées avec celles fournies à une autre question fermée (échelle de Lickert à quatre niveaux) analysant leur perception à propos des aménagements mis en place pour les aider à concilier études et activité sportive. Un total de 235 réponses a été collecté sur les six dernières années (cela représente un retour de 65% avec 37 à 50 réponses/an). Elles sont en cours d’analyse afin de proposer des profils en fonction de plusieurs variables indépendantes. La corrélation éventuelle entre le sentiment d'évolution sportive et l'aide apportée par les dispositifs mis en place par le statut sera également étudiée. Cette communication nous permettra de vérifier l’intérêt des démarches qui sont entreprises, de motiver les autorités académiques à poursuivre le projet ainsi que de mettre en avant des pistes d’action visant à encore améliorer le suivi pédagogique fourni aux étudiants sportifs de l’institution. [less ▲]

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See detailLa cour de récréation active: quels effets sur les élèves?
Vercruysse, Benoît; Brau, Amélie; Dachet, Dylan ULiege

Poster (2020, February 28)

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See detailAquatic Ecosystems are the Largest Source of Methane on Earth
Rosentreter, JA; Borges, Alberto ULiege; Raymond, PA et al

Poster (2020, February 16)

Methane concentrations in the atmosphere have almost tripled since the industrial revolution, contributing 16% of the additional radiative forcing by anthropogenic greenhouse gas emissions. Aquatic ... [more ▼]

Methane concentrations in the atmosphere have almost tripled since the industrial revolution, contributing 16% of the additional radiative forcing by anthropogenic greenhouse gas emissions. Aquatic ecosystems are an important but poorly constrained source of methane (CH4) to the atmosphere. Here, we present the first global methane emission assessment from all major natural, impacted and human-made aquatic ecosystems including streams and rivers, freshwater lakes and reservoirs, aquaculture ponds, estuaries, coastal vegetated wetlands (mangroves, salt-marshes, seagrasses), tidal flats, continental shelves and the open ocean, in comparison to recent estimates from natural wetlands and rice paddies. We find that aquatic systems are the largest source of methane globally with contributions from small lakes and coastal ocean ecosystems higher than previously estimated. We suggest that increased biogenic methane from aquatic ecosystems due to a combined effect of climate-feedbacks and human disturbance, may contribute more than expected to rising methane concentrations in the atmosphere. [less ▲]

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See detailTofacitinib induces clinical and endoscopic remission in biologic refractory Ulcerative Colitis patients: A real-world Belgian cohort study
Cremer, Anneline; Lobaton, Triana; VIEUJEAN, Sophie ULiege et al

Poster (2020, February 14)

Background Tofacitinib, an oral small molecule Janus kinase inhibitor, has been approved in 2018 for the treatment of moderate to severe ulcerative colitis (UC) in Europe. We report on real-world short ... [more ▼]

Background Tofacitinib, an oral small molecule Janus kinase inhibitor, has been approved in 2018 for the treatment of moderate to severe ulcerative colitis (UC) in Europe. We report on real-world short-term efficacy and safety data from a multicenter Belgium refractory cohort of UC patients with prior exposure to both anti-TNF and vedolizumab. Methods This is an observational, national, retrospective multicenter study including all UC active patients started on tofacitinib (10 mg BID) from 25 centers in Belgium between November 2018 to August 2019. Prospectively collected data were retrospectively analyzed according intention-to-treat. Primary endpoints were clinical and endoscopic response and remission rates at weeks 8 and 16. Clinical response and remission were defined as a reduction in Modified Clinical Mayo score (rectal bleeding, stool frequency) of ≥2 and ≤1, respectively. Endoscopic response and remission were defined as a reduction in Endoscopic Mayo score of ≥1 and ≤1, respectively. Complete endoscopic remission was defined as an Endoscopic Mayo score of 0. Descriptive statistics and Wilcoxon signed rank test were calculated using Medcal 19.1. Results Demographic and baseline data of the 70 included patients are presented in Table 1. Of note is that nearly all patients were refractory to at least one anti-TNF and vedolizumab. Median follow-up was 16 weeks (IQR 13-26). Fifty-four percent (38/70) of patients required prolonged induction at 10mg BID. Clinical evaluation was available in all patients at week 8 and 49 patients at week 16, while endoscopic data were available in 52 patients and 42 at weeks 8 and 16, respectively. Clinical response and remission, and endoscopic response and remission at week 8 and 16 are presented in Figures 1 and 2. Fifty percent (21/42) of the patients under steroids at baseline could have stopped steroids at 16 weeks. Median baseline Modified Mayo score (rectal bleeding, stool frequency and endoscopy) decreased from 7 (IQR 5- 8) to 4 (IQR 2-7) after 8 weeks (n=49) (p<0.0001), and down to 2 (IQR 1-5) at week 16 (n=40) (p<0.0001). Median CRP significantly decreased from baseline (5.3 mg/l, IQR [1.9–16.8]) to 1 mg/l at week 8 (IQR 0.5-6.2) (n=49) (p=0.003). Tofacitinib was well tolerated with only 1 reported case of single dermatome herpes zoster and no case of venous thromboembolism. Conclusions Tofacitinib very effectively induced short-term clinical and endoscopic response and remission even in a refractory cohort of patients with UC in a real-world clinical setting. During this short-term follow-up, tofacitinib was well tolerated with respect to adverse events. [less ▲]

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See detailIncreased Endoplasmic Reticulum stress specific chaperones characterise CD fibrosis epithelium tissues and participate to in vitro induction of intestinal fibroblasts differentiation
Vieujean, Sophie ULiege; Hu, Shurong; Bequet, Emeline et al

Poster (2020, February 14)

Background: Intestinal fibrosis is a complication of Crohn’s disease (CD) characterized by myofibroblasts and extracellular matrix accumulation within the submucosa and smooth muscles, leading to bowel ... [more ▼]

Background: Intestinal fibrosis is a complication of Crohn’s disease (CD) characterized by myofibroblasts and extracellular matrix accumulation within the submucosa and smooth muscles, leading to bowel strictures. No medical treatment exists to treat or reverse intestinal fibrosis leading often to surgical resection. The potential role of intestinal epithelium in the fibrotic process remains poorly defined. Methods: We performed a pilot study on ileal fibrostricturing CD surgical samples (n=5), comparing the proteome of surface epithelium isolated by laser capture microdissection in normal and fibrotic zones. Confirmation of the specific protein increases was obtained by immunohistochemistry in colonic and ileal samples of CD (n=44) compared to healthy subjects (n=40), as well as in intestinal epithelial cell line under induced Endoplasmic Reticulum (ER) stress. A model of fibroblast to myofibroblast differentiation induction was also challenged using preconditioned media of intestinal epithelial cells after a pulsed ER stress. Results: Label free proteomics revealed high ER stress in the epithelium surrounding fibrotic bowel wall, involving Anterior gradient protein 2 homolog (AGR2) and 78kDA glucose regulated protein (BiP). Confirmation of both proteins increase was obtained by immunohistochemistry. ER stress induction in intestinal epithelial cells was associated with an intracellular increase of AGR2, BiP and ER stress markers as sXPB1 and CHOP. AGR2 was also detected in the culture medium of these epithelial cells and myofibroblast differentiation was obtained using this culture medium. Conclusions: The increase of ER stress proteins observed in fibrostenosing tissues together with These preliminary evidences of fibroblast to myofibrobast differentiation obtained by paracrine action of intestinal epithelial cell preconditioned to ER stress induction, suggest a role of epithelial ER stress in Crohn’s disease intestinal fibrosis. [less ▲]

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See detailDicarbonyl stress induces an epigenetic deregulation leading to a pro-migratory phenotype in breast cancer.
Tiamiou, Assia ULiege; Dube, Gaurav; Bizet, Martin et al

Poster (2020, February 07)

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See detailMethylglyoxal stress contributes to immunosuppression in breast cancer
Wissocq, Tom ULiege; Hubert, Pascale ULiege; Caprasse, Maurine ULiege et al

Poster (2020, February 07)

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See detailPIAF : développer la Pensée Informatique et Algorithmique dans l'enseignement Fondamental
Busana, Gilbert; Denis, Brigitte ULiege; Duflot-Kremer, Marie et al

Poster (2020, February 06)

Dans cet article, nous présentons les objectifs et premières réalisations du projet PIAF soutenu par l’Union Européenne et visant à développer l’apprentissage de la pensée informatique et algorithmique ... [more ▼]

Dans cet article, nous présentons les objectifs et premières réalisations du projet PIAF soutenu par l’Union Européenne et visant à développer l’apprentissage de la pensée informatique et algorithmique dans l’enseignement fondamental. Ce projet rassemble des chercheur·e·s en sciences de l’éducation et en informatique, provenant de quatre pays (Allemagne, Belgique, France et Luxembourg), autour du thème de la formation des enseignant·e·s. Plus concrètement, il s’agit de définir un cadre (référentiel de compétences, scénarios pédagogiques) permettant aux enseignant·e·s de (i) s’approprier le concept de pensée informatique et algorithmique et de (ii) mettre en œuvre des activités d’apprentissage favorisant le développement de cette pensée chez l’enfant. [less ▲]

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