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See detailLes trajectoires professionnelles des femmes avec diplôme universitaire en République Démocratique du Congo au travers des récits de vie de femmes de trois générations (moins de 30 ans, 30 a 40 ans, plus de 40 ans)
Kitenge Maningo, Sara ULiege

Poster (2021, October 07)

Cet article vise à décrire les trajectoires professionnelles des femmes avec diplôme universitaire en République Démocratique du Congo au travers des récits de vie de femmes de trois générations (moins de ... [more ▼]

Cet article vise à décrire les trajectoires professionnelles des femmes avec diplôme universitaire en République Démocratique du Congo au travers des récits de vie de femmes de trois générations (moins de 30 ans, 30 à 40 ans, plus de 40 ans), identifier les causes individuelles, organisationnelles, et sociétales de leurs choix, réorientations et changement, les succès, mais aussi les difficultés, les échecs, et les frustrations qu’elles connaissent dans leurs parcours professionnels, ainsi proposer des plans d’actions pour l’amélioration de l’égalité entre les hommes et les femmes en RDC. Notre positionnement épistémologique étant constructiviste, nous cherchons à voir qu’elle est la perception que les femmes ont de leurs parcours professionnel. C’est ainsi que nous avons jugé intéressant de recourir à l’approche qualitative, pour collecter les récits de vie de ces femmes et faire une analyse thématique de ce qu’elles nous ont raconté sur leur vécu professionnel, c’est elles qui vont isoler les éléments qu’elles jugent importants et qui ont influencé leurs trajectoires professionnelles. [less ▲]

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See detailInternational Symposium: Eroticism, Poetic Concretism, and Visuality (1960-1970)
Minuto, Maria Elena ULiege

Poster (2021, September 17)

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See detailConceptual model of the emergence of the real utility of people with disabilities
Kyungu Tchikala, Daniel ULiege

Poster (2021, July 07)

Les modèles actuels d’analyse et d’intervention dans le domaine de la participation socio-économique des personnes en situation de handicap omettent, à notre avis, certaines variables dont le degré ... [more ▼]

Les modèles actuels d’analyse et d’intervention dans le domaine de la participation socio-économique des personnes en situation de handicap omettent, à notre avis, certaines variables dont le degré d’explication sur le niveau de participation des personnes en situation de handicap serait très élevé. Partant de la théorie de stigmates, de la théorie des perspectives et du concept d’asymétrie d’informations, nous suggérons que l’un des obstacles majeurs auxquels les PSH se heurtent pour être insérées sur le plan socio-économique est l’asymétrie d’informations sur leur degré d’utilité réelle, due à la stigmatisation dont elles sont victimes. Cette asymétrie d’information fait baisser le niveau d’utilité réelle de cette catégorie de personnes en les obligeant à vivre des situations d’exclusion sociale : discrimination et non accès au capital social. Elle crée un écart entre leur utilité réelle et l’utilité perçue par les demandeurs de la force du travail. La meilleure façon de faire exploser l’utilité réelle des personnes en situation de handicap est de faire exploser leur créativité via l’entrepreneuriat où la compétition concerne le produit et non pas les apparences. Ensuite, communiquer largement sur les réalisations de ces initiatives pour améliorer l’accès des demandeurs de la force du travail à l’information sur l’utilité réelle des PSH. Cette recommandation est aussi conforme aux aspirations des PSH comme le démontrent les résultats des études empiriques. A long terme, les effets de cette stratégie finissent par impacter positivement le comportement des demandeurs de la force du travail à l’égard des personnes en situation de handicap sur le marché du travail salarié. L’ensemble du cadre d’analyse et d’intervention que nous proposons se dénomme le modèle d’éclosion de l’utilité réelle des personnes en situation de handicap. [less ▲]

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See detailProtein encapsulation in functionalized silica gel for bone reconstruction application
Tilkin, Rémi ULiege; Colle, Xavier; Mahy, Julien ULiege et al

Poster (2021, July 05)

Over the last decades, temporary porous matrices, called scaffolds, have increasingly gained in importance for bone regeneration. These matrices serves for the support and control of the spatial ... [more ▼]

Over the last decades, temporary porous matrices, called scaffolds, have increasingly gained in importance for bone regeneration. These matrices serves for the support and control of the spatial organization of stem cells. Various materials have been proposed for their conception. Nevertheless, studies have shown a lack of cell differentiation and bone production at their surface. The aim of this study is the adjustment of the surface functionalization of hydroxyapatite via sol-gel coating of silica to promote the local sustained delivery of a model protein (i.e. Soybean Trypsin Inhibitor, STI). In this optic, the influence of the functional groups present at the surface of silica pores on the release kinetics of the protein and on its activity has been studied via two alternative methods: (1) the impregnation of already synthesized silica gels in the protein solution (i.e. ex situ method), and (2) the direct incorporation of the protein during the gel synthesis (i.e. in situ method). For the ex situ method, tetraethylorthosilicate (TEOS) was used as main silica precursor and 3-(2-aminoethylamino) propyltrimethoxysilane (EDAS) or phenyltrimethoxysilane (PTMS) as nucleating agents in alcoholic medium and under basic conditions. For the in situ method, tetramethylorthosicilate (TMOS) served as silica precursor after hydrolysis under acid conditions. The nucleating agents were also EDAS or PTMS. The results of the textural analysis revealed that ex situ gels presented a porous funnel-like structure (micro-, meso-, and macropores) while in situ gels presented a micro- and mesoporous structure. Regarding the in vitro release profile of STI, in both methods, the presence of phenyl caused a large but total entrapment inside the pores. For the calcined and amine modified ex situ samples, a burst over the 24 h of incubation was present followed by a plateau for the calcined samples and by a continuous release for the amine modified samples. The inhibitory activity decreased after 4 weeks of incubation to a low value (i.e. around 30 %) for the amine samples and was equal to 0 in the case of the calcined samples. These differences could be explained by the sign difference of the charges present at the surface of the pores (interaction of negatively charged STI with negative charges of calcined samples vs positive charges of amine modified samples). For the in situ samples, a continuous release up to 8 days could be observed. Interestingly enough, STI released after 4 weeks of incubation presented a high remaining activity (i.e. around 80 %). [less ▲]

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See detailQUANTIFICATION AND CHARACTERIZATION OF MINERAL OIL IN FISH FEED BY LC-GC-FID AND LC-GC×GC-TOFMS/FID.
Bauwens, Grégory ULiege; Conchione, Chiara; Moret, Sabrina et al

Poster (2021, July 02)

Mineral oil, mainly composed by mineral oil saturated and aromatic hydrocarbons (MOSH and MOAH), is an ubiquitous food contaminants of high concern in the European Union for it potential toxicity ... [more ▼]

Mineral oil, mainly composed by mineral oil saturated and aromatic hydrocarbons (MOSH and MOAH), is an ubiquitous food contaminants of high concern in the European Union for it potential toxicity. Moreover, the analytical procedure for their determination is highly sample dependent and not robustly validated. High attention is devoted to human food, while oftenreduced attention is paid to animal feed, turning out in higher contamination occurrence. In this study 22 different fish feed products were selected (7 commercial feed, 5 feedstuff and 10 from sperimental diets). The analysis were performed by both LC-GC-FID as the reference method and LC-GC×GC-TOFMS/FID for confirmation of the quantity found and a more detailed characterization of the contamination [1]. The samples were first extracted by performing a microwave-assisted saponification and simultaneous extraction step, followed by an offline auxiliary technique, such as epoxidation to remove most of the interferents of the MOAH fraction and an aluminum oxide purification step when necessary on the MOSH fraction to remove overloading alkanes. The results indicate a constant contamination of MOSH ranging between 7 and 30 mg/kg and a contamination of MOAH ranging from 0.5 to 5 mg/kg. [less ▲]

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See detailHYPHENATION AND MULTIDIMENSIONALITY AS SAMPLE PREPARATION ALLEYS IN MOSH AND MOAH ANALYSIS
Bauwens, Grégory ULiege; Purcaro, Giorgia ULiege

Poster (2021, July 02)

Multidimensional separation techniques are a powerful class of analytical techniques that allow to increase the separation power of complex samples, most frequently in an automated and hyphenated way. The ... [more ▼]

Multidimensional separation techniques are a powerful class of analytical techniques that allow to increase the separation power of complex samples, most frequently in an automated and hyphenated way. The most important parameter two optimize is the orthogonality of the separation techniques in order to maximize the overall separation. Most usually two chromatographic dimensions are coupled for this purposes (e.g., GC-GC or GC×GC, LC-GC or LC×GC, LC-LC or LC×LC), with often the addition of mass spectrometry as an extra dimension. Few samples really benefit for additional dimensions, and mineral oil, more specifically mineral oil saturated and aromatic hydrocarbons (MOSH and MOAH) are one of this. The reference method for this analysis is the LC-GC-FID method developed by Grob and Biedermann in 2009 [1]. In this method, the LC step is used as a preliminary sample preparation step to separate MOSH and MOAH and the rest of the sample (mainly lipid components). Beside LC-GC, comprehensive gas chromatography (GC×GC) has been proposed to better investigate the identity of the MOSH and MOAH fraction. In this work, we proposed a fully integrated platform, namely LC-GC×GC-ToFMS/FID, coupled with a novel integration algorithm, to improve results reliability. Every dimension involved was an important alley for sample preparation allowing an additional “chromatographic purification” of the MOSH and MOAH hump from the interferences still remaining after the previous LC step [2]. [less ▲]

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See detailLarge-scale atomic data calculations in Ce V-X ions for application to early kilonova emission from neutron star mergers
Carvajal Gallego, H.; Palmeri, P.; Quinet, Pascal ULiege

Poster (2021, July)

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See detailPotential Role of Epithelial Protein Disulphide Isomerases in Crohn’s Disease Fibrosis
VIEUJEAN, Sophie ULiege; Hu, Shurong; Bequet, Emeline ULiege et al

Poster (2021, July)

Background and aims: Intestinal fibrosis is a common complication of Crohn’s disease (CD) characterized by an accumulation of fibroblasts differentiating into activated myofibroblasts secreting excessive ... [more ▼]

Background and aims: Intestinal fibrosis is a common complication of Crohn’s disease (CD) characterized by an accumulation of fibroblasts differentiating into activated myofibroblasts secreting excessive extracellular matrix. In in-vitro experiments, this myofibroblastic differentiation is elicited by a whole series of factors among which transforming growth factor β1 (TGF-β1) seems to play a key role. The potential role of the intestinal epithelium in this fibrotic process remains poorly defined. Methods: We performed a pilot proteomic study comparing the proteome of surface epithelium isolated by laser-capture microdissection in normal and fibrotic zones of resected ileal CD strictures (13 zones collected in 5 patients). The pro-fibrotic role of selected epithelial proteins was investigated through in-vitro experiments using HT-29 epithelial cells and a CCD-18Co fibroblast to myofibroblast differentiation model. Results: Proteomic study revealed an endoplasmic reticulum (ER) stress proteins increase in the epithelium of CD ileal fibrotic strictures, including Anterior gradient protein 2 homolog (AGR2), Protein disulphide isomerase A6 (PDIA6) and Endoplasmic reticulum resident protein 44 (ERP44) which are 3 protein disulphide isomerases. In HT-29 cells, tunicamycin-induced ER stress triggered AGR2, PDIA6, ERP44 as well as TGF β1 intracellular expression and their secretion. Supernatant of these HT-29 cells, pre-conditioned by tunicamycin (Tm), led to a myofibroblastic differentiation when applied on CCD-18Co fibroblasts. The application of blocking agents for AGR2, PDIA6, ERP44 or TGF β1 in the supernatant of these Tm pre conditioned HT-29 cells, attenuated the myofibroblastic differentiation induced by this supernatant, suggesting a pro-fibrotic role of these secreted epithelial proteins. Conclusions: The development of CD fibrotic strictures may involve ER stress in epithelial cells, releasing a whole set of proteins into their environment, including AGR2, PDIA6, ERP44 as well as TGF-β1, which could exercise a pro-fibrotic role through a paracrine action. [less ▲]

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See detailA new set of oscillator strengths in moderately charged indium ions for the spectral analysis of hot white dwarfs
Gamrath, S.; Quinet, Pascal ULiege; Palmeri, P.

Poster (2021, July)

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See detailCalculated oscillator strengths for radiative transitions of cosmochronological interest in singly ionized thorium (Th II)
Gamrath, S.; Quinet, Pascal ULiege; Palmeri, P. et al

Poster (2021, July)

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See detailExtreme depolarisation for any spin
Denis, Jérôme ULiege; Martin, John ULiege

Poster (2021, July)

We present a detailed study of the depolarization dynamics of an individual spin with an arbitrary spin quantum number j, or, equivalently, of a system of N = 2j constituent spin-1/2 initially in a ... [more ▼]

We present a detailed study of the depolarization dynamics of an individual spin with an arbitrary spin quantum number j, or, equivalently, of a system of N = 2j constituent spin-1/2 initially in a symmetric state undergoing collective depolarization. In particular, we identify the most superdecoherent states. In the case of isotropic depolarization, we show that a class of maximally entangled pure states distinct from GHZ and W states, a.k.a. spin anticoherent states [1,2], display the highest decoherence rate for any number of spins. Moreover, we find that these states become absolutely separable after a time which does not depend on the number of spins. We also prove that entanglement is a necessary and sufficient condition, both for pure and mixed states, for superdecoherence to take place [3]. Finally, for anisotropic depolarization, we identify not only the states with the highest initial decoherence rate, but also the states that lose their purity most rapidly over any finite time for a few spins. References: [1] J. Zimba, Electron. J. Theor. Phys. 3, 143 (2006). [2] D. Baguette et al., Phys. Rev. A 90, 032314 (2014). [3] G. M. Palma et al., Proc. R. Soc. London, Ser. A 452, 567 (1996). [less ▲]

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See detailLocal Mesenchymal Stem Cells injection in Crohn’s disease strictures: a phase I-II, open-label clinical study
VIEUJEAN, Sophie ULiege; LOLY, Jean-Philippe ULiege; BOUTAFFALA, Layla ULiege et al

Poster (2021, July)

Background and aim: Intestinal fibrosis is a common complication of Crohn's disease (CD) leading to progressive bowel stricture formation. Mesenchymal stem cells (MSCs), known for their immunomodulatory ... [more ▼]

Background and aim: Intestinal fibrosis is a common complication of Crohn's disease (CD) leading to progressive bowel stricture formation. Mesenchymal stem cells (MSCs), known for their immunomodulatory, anti-inflammatory and anti-fibrotic properties, could be a potential therapy in this frequently fibro-inflammatory condition. In this phase I–II open-label pilot trial, we aimed to assess safety and efficacy of local MSCs injection in CD strictures. Methods: CD patients with a non-passable stricture, length from 2 to 5 cm, accessible by ileocolonoscopy, but without intestinal obstruction, fistulas, or abscess, could be included. A total of 3X107 allogenic bone-marrow derived MSCs were equally injected in the 4 quadrants of the strictured bowel wall during an ileocolonoscopy. Adverse events and clinical scores (Crohn Disease Activity Index, Short Health Scale and Crohn Disease Obstructive Score) were evaluated at each follow-up visit (at week 4, 12, 24 and 48) while endoscopy was performed at baseline, W12 and W48. The main judgement criteria for efficacy was the complete (defined by the ability to pass the ileocolonoscope) or partial (defined by a diameter increase) resolution of the stricture at 12 weeks. Other efficacy criteria included complete or partial resolution of the stricture at 48 weeks as well as the evolution of clinical scores between weeks 0, 12 and 48. Results: Between 2018 and 2020, we performed 11 local MSCs injections in 10 CD patients (6 female; aged to 38-65 years; median 45 years old; 70% were smoker). The strictures’ (3 primary, 7 anastomotic) location was as follows: 7 at an ileo-colonic or ileo-rectal anastomosis, 1 colonic and 2 of the ileocecal valve. MSCs injections were well tolerated but a total of 5 hospitalizations for occlusion were reported (2 secondary to a different stricture than the injected one) leading to a surgical resection for one patient and an endoscopic dilatation for another one. Neither intestinal perforation nor intra-abdominal fistula or abscess was reported. At 12 weeks, 5 patients (45%) presented a stricture improvement with a complete resolution for 2 and a partial resolution for 3. Of the 11 MSCs injections, 6 strictures were re-evaluated at week 48 (2 patients still undergoing follow-up, 1 operated, 1 dilated, and 1 lost to follow-up), 4 patients had a complete resolution and 1 had a partial resolution. The evolution of clinical scores between weeks 0, 12 and 48 (Figure 1) was not statistically significant. Conclusion: Local MSCs injection in non-passable CD stricture was well tolerated over the short term but several occlusions were reported in the follow-up. Combining the effects of MSCs with the proven effect of endoscopic balloon dilatation could possibly improve the outcome of CD stricture. [less ▲]

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See detailPaleobiology of an Ediacaran acanthomorphic acritarch
Domino, Samuel ULiege; Loron, Corentin ULiege; Sforna, Marie-Catherine ULiege et al

Poster (2021, July)

The Ediacaran is a crucial time of changes in climatic and redox conditions, nutrient availability, and diversification of eukaryotes, including planktonic algae and the first unambiguous metazoans ... [more ▼]

The Ediacaran is a crucial time of changes in climatic and redox conditions, nutrient availability, and diversification of eukaryotes, including planktonic algae and the first unambiguous metazoans. During this period, new and highly diverse organic-walled eukaryotic microfossils appear worldwide, but their identity remains enigmatic. They are called the “Doushantuo-Pertatataka type Acanthomorphic acritarchs” (DPA). Their morphological complexity (diverse types of processes expanding from the vesicle wall) evidences their eukaryoticity. Several hypotheses for their affinity have been proposed, tentatively interpreting a few of these microfossils as eggs of metazoans [1,2] or cysts of chloroplastid green algae [2-5], but they remain ambiguous. To test these hypotheses, we present a morphological, ultrastructural and spectroscopic characterisation of one of the most emblematic DPA acritarchs, Gyalosphaeridium pulchrum. Such analytical combination has never been performed all together on a DPA taxon. The fossils come from the Munta-1 drillcore from the Tanana formation in the eastern Officer basin in Australia. Quantitative analyses [6] of microfossils through the drillcore revealed assemblages dominated by simple smooth-walled sphaeromorphs, and less abundant but very diverse and exquisitely preserved acanthomorphs, previously reported [7]. Drawing on our analyses and previous work, we discuss the possible diagnostic combinations of characters to pinpoint the clade to which the microfossils may belong. This approach, extended to more DPA taxa, will permit to constrain the appearance of eukaryotic clades in the Ediacaran and their role in the complexification of late Precambrian ecosystems. It will also provide guidelines for future identification of similarly enigmatic microfossils, frequent in Precambrian and Paleozoic strata. [1] Cohen, Knoll & Kodner (2009), Proceedings of the National Academy of Sciences 106, 6519–6524. [2] Willman (2009), Geobiology 7, 8–20. [3] Marshall, Javaux, Knoll & Walter (2005), Precambrian Research 138, 208–224. [4] Moczydłowska & Liu (2021), Geological Magazine, doi:10.1017/S0016756820001405. [5] Willman & Moczydłowska (2007), Lethaia 40, 111–123. [6] Calers (2020), Diversification de la biosphère après un impact de météorite (Acraman, Australie) au Néoprotérozoïque, M. Sc. thesis, Université de Liège. [7] Grey (2005), Memoirs of the Association of Australasian Palaeontologists 31, 439 pp. [less ▲]

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See detailDevelopment and validation of methods using solid-phase extraction, offline derivatization and UHPLC-ESI(+)-MS/MS for the quantification of estrogenic compounds at ultra-trace levels in different types of water
Glineur, Alex ULiege; Nott, Katherine; Purcaro, Giorgia ULiege

Poster (2021, June 30)

Natural estrogens (estrone: E1, 17-β-estradiol: E2, estriol: E3) and synthetic estrogen (17-α-ethinylestradiol: EE2) belong to the group of endocrine disrupting compounds (EDCs), leading to deleterious ... [more ▼]

Natural estrogens (estrone: E1, 17-β-estradiol: E2, estriol: E3) and synthetic estrogen (17-α-ethinylestradiol: EE2) belong to the group of endocrine disrupting compounds (EDCs), leading to deleterious effects on aquatic biota, even at sub-ng/L level of concentration. The European Union (EU) published a Watch-List of substances including these estrogenic compounds and specified maximum acceptable method detection limits (LODs) of 0.035 ng/L for EE2 and 0.4 ng/L for E1 and E2. Besides, E2 will have to be monitored as an indicator of the occurrence of EDCs in water intended for human consumption, with a parametric value of 1 ng/L (EU 2020/2184). Attaining these limits represents a challenge even with the most up-to-date analytical tools, particularly in surface water. Initially, an automated solid-phase extraction (SPE) method using a single cartridge with hydrophilic-lipophilic balanced copolymer was developed and validated. This method is suitable for clean aqueous matrices (drinking water) and allows for high sample throughput. However, for more complex matrices such as surface water/effluent of wastewater treatment plant, an additional purification step was necessary. After a careful optimization of the sample preparation parameters to maximize the recoveries, the extraction of a whole water sample on a SPE disk, followed by purification on a Florisil SPE cartridge, allowed to reach the sensitivity required by the EU Watch-List. The final optimized method was validated (precision and trueness) in seven surface water from different Belgium locations. [less ▲]

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See detailFurther investigation of the rapid control of male sexual behavior by neuroestrogens in mice
de Bournonville, Catherine ULiege; Lemoine, Philippine ULiege; Foidart, Jean-Michel ULiege et al

Poster (2021, June 29)

Neuroestrogens play a key role in the activation of male sexual behavior by testosterone through their nuclear- and membrane-initiated actions. Studies conducted in birds suggested that membrane vs ... [more ▼]

Neuroestrogens play a key role in the activation of male sexual behavior by testosterone through their nuclear- and membrane-initiated actions. Studies conducted in birds suggested that membrane vs. nuclear actions of neuroestrogens differentially control sexual motivation and performance. In mice, estrogen receptor alpha (ERα) plays a major role in the control of male sexual behavior. However, whether the translocation ERα and its activation at the membrane rapidly affect male sexual behavior remains unclear. Recently, a mouse model (C451A-ERα) carrying a mutated ERα unable to traffic to and signal from the membrane was generated. Moreover, the natural estrogen estetrol (E4) has been described to act as an agonist of nuclear estrogen receptors but as an antagonist on their membrane-associated fraction. Here, we used the complementary properties of estetrol and C451A-ERα mice to investigate the role of membrane ERα (mERα) on male sexual motivation and performance. Regardless of the genotype, systemic aromatase blockade decreased within 10 min sexual performance and motivation, measured by the time spent close to an estrous female. E4 rapidly decreased sexual performance only in wild-type males and had no effect on sexual motivation. Together, these data confirmed the key role of aromatization in the rapid control of male sexual performance and extended this conclusion to sexual motivation. Moreover, E4, likely acting on mERα rapidly inhibits sexual performance, but not sexual motivation. Finally, the inhibitory effect of aromatase blockade in C451A-ERα mice suggests that another estrogen receptor than mERα also regulates both aspects of male sexual behavior. [less ▲]

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See detailPhotoperiodic control of singing behavior and reproductive physiology in male fife fancy canaries
Chiver, Ioana ULiege; LALLEMAND, François ULiege; Cornil, Charlotte ULiege et al

Poster (2021, June 29)

Temperate-zone birds often display marked seasonal changes in reproductive behaviors and in the underlying hormonal and neural mechanisms. These changes have been extensively studied in canaries (Serinus ... [more ▼]

Temperate-zone birds often display marked seasonal changes in reproductive behaviors and in the underlying hormonal and neural mechanisms. These changes have been extensively studied in canaries (Serinus canaria) and there is emerging evidence of variation among strains in physiological responses to seasonal cues. Fife fancy male canaries were previously shown to change their reproductive physiology in response to variations in day length but it remained unclear whether they display absolute refractoriness, as Border canaries do, or only display relative refractoriness or simply track day length to control gonadal activity, singing behavior and the associated neural plasticity. Male birds maintained on 8L:16D (SD) for 6 months that had become reproductively competent (high song output and large testes) were divided into two groups: control birds remained on SD and experimental birds were switched to long days (16L:8D). During the following 11 weeks, singing behavior (recorded and quantitatively analyzed for 3X2 hours everyweek) and gonadal size (repeatedly measured by CT X-ray scans) remained similar for birds in both groups except for trill numbers that increased in the experimental group. Prolonged exposure to SD had thus induced a nearly full activation of reproductive physiology and behavior. Day length was then decreased back to 8L:16D for experimental birds which immediately induced a cessation of song, a decrease in testes size and a decrease in the volume of song control nuclei (Area X, HVC, RA). These data demonstrate that Fife fancy canaries sharply respond to changes in photoperiod but only display relative photorefractoriness. [less ▲]

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See detailDIAGNOSIS OF HEMATOPOIETIC MALIGNANCIES WITH GERMLINE PREDISPOSITION : A FILTERED WHOLE EXOME SEQUENCING APPROACH
FERNANDEZ CARAZO, Rafael ULiege; Koopmansch, Benjamin; Charloteaux, Benoit et al

Poster (2021, June 17)

Background: In the frame of the development of new analytical methods for the diagnostic of patients suffering of suspected inherited malignancies with poor access to rapid diagnosis due to a restricted ... [more ▼]

Background: In the frame of the development of new analytical methods for the diagnostic of patients suffering of suspected inherited malignancies with poor access to rapid diagnosis due to a restricted number of analytical sites or the current use of non-comprehensive targeted panels, we aimed at developing a new NGS panel for the analysis of several haematological diseases based on a filtered whole exome sequencing approach. Aims: Haematological diseases incorporated in the panel include myelodysplasic syndromes, acute myeloid leukemia, inherited bone marrow failure syndromes, Fanconi anemia, Diamond Blackfan anemia, dyskeratosis congenita, Telomeropathies and severe congenital neutropenia. Methods: Clinical exome is sequenced with the SureSelect Hulan Exome V6, recovering information for about 20k genes, representing ca. 180k exons. A newly designed variant filter based on an in-house pipeline tree (Alissa Interpret) for the flagging of retained variants, allows for the selection and labeling of ca. 100 variants per patient. Variants are categorized following the ACMG guidelines for the interpretation of inherited variants and reported in the context of the patient malignancies. The set of genes has been selected from a deep insight to the most recent literature and guidelines and covers 85 full (exonic) genes. The ncRNA gene TERC and intronic regions from RETL1 are also included in the set. The analytical pipeline considers the analysis of single patients, corroboration of relevant inherited germline mutations from fibroblasts and/or trio analysis including first or second relatives. Applications cover from simple diagnostic from single patients to familiar studies or donor compatibility analysis. Results: Inherited Haematological Malignancies are a heterogeneous group of malignancies not yet fully understood and in constant evolution. In this context, flexibility is a key concept to avoid analytical obsolescence. Due to the wide range of genes covered by the WES approach, significant genes could be further updated, with a minimal effort, to the panel. Summary/Conclusion: We therefore aim to provide physicians with a comprehensive diagnostic panel for the diagnostic work-up of patients affected (or suspected to be affected) by inherited haematological malignancies, and related diseases enhancing the patient’s chances to benefit from a personalized medicine approach; together with a view to increase the knowledge about those (rare) conditions [less ▲]

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See detailThe continuum of sexuality in older age: a Belgian cross-sectional study
Cismaru Inescu, Adina ULiege; Hahaut, Bastien ULiege; Adam, Stéphane ULiege et al

Poster (2021, June 12)

This presentation aims to explore sexual activity, sexual relationships, sexual satisfaction, beliefs and attitudes on later life sexuality using data from a Belgian national study.

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See detailPast 12-months sexual violence in older adults - a Belgian prevalence study
Cismaru Inescu, Adina ULiege; Nobels, Anne; Hahaut, Bastien ULiege et al

Poster (2021, June 11)

Sexual violence (SV) against older adults (OA) is often studied within the frame of elder abuse or as a subtype of physical abuse. This study aims to explore the prevalence of SV against older adults ... [more ▼]

Sexual violence (SV) against older adults (OA) is often studied within the frame of elder abuse or as a subtype of physical abuse. This study aims to explore the prevalence of SV against older adults, during the lifetime and in the past 12 months. [less ▲]

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See detailRoom to improve negative implicit attitudes towards sexuality of older adults – French-speaking sample
Cismaru Inescu, Adina ULiege; Hahaut, Bastien ULiege; Kempeneers, Philippe ULiege et al

Poster (2021, June 11)

Despite an overall improvement in attitudes towards older adults' (OA) sexuality, ageist stereotypes still exist in society (Beckman et al, 2008). Based on this observation, this study aims to assess the ... [more ▼]

Despite an overall improvement in attitudes towards older adults' (OA) sexuality, ageist stereotypes still exist in society (Beckman et al, 2008). Based on this observation, this study aims to assess the knowledge and attitudes towards the sexuality of OA in a French-speaking adult sample. [less ▲]

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See detailThe Impact of Green Space Attendance on Social Orientation in Periods of Health Crisis
Noël, Tania ULiege; El Boujjoufi, Mohamed; Dardenne, Benoît ULiege

Poster (2021, June 04)

Human society has always been impacted by some sort of crisis from its very beginning onwards. This includes pandemics such as the COVID-19 crisis that we are currently facing. While pandemics have always ... [more ▼]

Human society has always been impacted by some sort of crisis from its very beginning onwards. This includes pandemics such as the COVID-19 crisis that we are currently facing. While pandemics have always existed, their number keeps increasing, and the explanation for this phenomenon partly lies in the environmental crisis we are currently experiencing. In this study, we highlight the potential of urban green spaces in the management of such societal crises. A lot of research shows the impact of nature exposure on pro-social attitudes and interpersonal relationships. An individual's social life is an essential factor when it comes to his resilience skills, especially in times of crisis. Feelings of awe and perceptions of beauty are two qualities of the natural environment that research documents to partially account for the effects of nature on human social behavior. However, we know that most people do not have access to “awe-inspiring” green spaces on a daily basis. Having access to the local urban park is often the only green space within walking distance for most individuals, especially in low-income districts. A survey was launched in April 2020 to better understand the characteristics of “daily urban green spaces” that can influence pro-social behaviour during a pandemic. This study examines the impact of green spaces attendance on social orientation according to the perceived beauty of these spaces and, considering the pandemic context, according to his attendance rate (if the place is sparsely or densely crowded). Indeed, it is legitimate to wonder if attending green spaces confers the same social benefits during a pandemic, when people are worried meeting and interacting with strangers given the increase infection risk this represents. We therefore suppose that there is a positive link between green areas and social orientation, but that this link only exists for places that are perceived as pleasant and little frequented. 1206 participants (972 female and 234 male, aged between 17 and 77 years, M = 28.74, SD = 12.87) were recruited through an online survey on social media. The survey started with a social orientation measure (the orientation slider measure - SVO; Murphy, Ackermann, & Handgraaf, 2011), asking participants to allocate points to themselves and to a hypothetical other. The real purpose of this measure was hidden from participants. Participants than answered measures to determine their perception of the most regularly visited green space during the lockdown. Different co-variates were also included. The results from this survey show that the more the use of green spaces increase, the more social orientation is also enhanced, but only in low crowded spaces (b = 0.059, t = 2.006, SE = 0.029, p = 0.045). Perceived beauty has no impact on the link between frequentation and social orientation. These results show the importance of multiplying green spaces in our cities in order to decongest the existing green areas, but also of thinking about their design and their location in the urban space, in order to reduce the feeling of overcrowding. This seems all the more important within underprivileged neighborhoods, which gather more vulnerable populations to the consequences of health, economic and social crises. [less ▲]

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See detailProbing interfaces in perovskite solar cells by intensity modulated photocurrent spectroscopy
Kumar, Sunil; Balty, François ULiege; Sliti, Naama ULiege et al

Poster (2021, June 02)

Detailed reference viewed: 34 (10 ULiège)
See detailTheoretical study of the opto-electronic properties of Cu2ZnXS4 (X=Sn,Ge,Si) kesterites for solar cell efficiency modelling.
Ratz, Thomas ULiege; Raty, Jean-Yves ULiege; Brammertz, Guy et al

Poster (2021, June 02)

In this work, first-principles calculations of Cu2ZnSnS4, Cu2ZnGeS4 and Cu2ZnSiS4 are per- formed to highlight the impact of the cationic substitution on the structural, electronic and optical properties ... [more ▼]

In this work, first-principles calculations of Cu2ZnSnS4, Cu2ZnGeS4 and Cu2ZnSiS4 are per- formed to highlight the impact of the cationic substitution on the structural, electronic and optical properties of kesterite compounds. Direct bandgaps are reported with values of 1.32, 1.89 and 3.06 eV respectively for Cu2ZnSnS4, Cu2ZnGeS4 and Cu2ZnSiS4 and absorption coefficients of the order of 10^4 cm−1 are obtained, indicating the applicability of these materials as absorber layer for solar cell applications. In the second part of this study, ab initio results are used as input data to model the electrical power conversion efficiency of kesterite-based solar cells. In that perspective, we used an improved version of the Shockley-Queisser model including non-radiative recombination via an external parameter defined as the internal quantum efficiency. Based on predicted optimal absorber layer thicknesses, the variation of the solar cell maximal efficiency is studied as a function of the non-radiative recombination rate. Maximal efficiencies of 25.71, 19.85 and 3.10 % are reported respectively for Cu2ZnSnS4, Cu2ZnGeS4 and Cu2ZnSiS4 for vanishing non-radiative recombination rate. Using an internal quantum efficiency value providing experimentally comparable VOC values, cell efficiencies of 15.88, 14.98 and 2.66 % are reported respectively for Cu2ZnSnS4, Cu2ZnGeS4 and Cu2ZnSiS4. We confirm the suitability of Cu2ZnSnS4 in single junction solar cells, with a possible efficiency improvement of nearly 10% enabled through the reduction of the non-radiative recombination rate. In addition, Cu2ZnGeS4 appears to be an interesting candidate as top cell absorber layer for tandem approaches whereas Cu2ZnSiS4 might be interesting for transparent photovoltaic windows. [less ▲]

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See detailNumerical simulation of transparent heterojunctions based on Cu2O thin films.
Sliti, Naama ULiege; Ratz, Thomas ULiege; Touihri, Saad et al

Poster (2021, June 02)

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See detailContentless Thinking is Associated with Whole-Brain Positive Inter-Areal Connectivity Patterns
Mortaheb, Sepehr ULiege; Van Calster, Laurens ULiege; Boulakis, Paradeisios Alexandros et al

Poster (2021, June)

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See detailMyoferlin, a promising therapeutic target in PDAC, is located in mitochondria-associated membranes
Anania, Sandy ULiege; Boumahd, Yasmine ULiege; Peiffer, Raphaël ULiege et al

Poster (2021, June)

Pancreatic cancer has one of the lowest survival rates with more than 90% of patients dying of the disease. It is predicted that pancreatic cancer will surpass breast cancer death by 2025. Therefore ... [more ▼]

Pancreatic cancer has one of the lowest survival rates with more than 90% of patients dying of the disease. It is predicted that pancreatic cancer will surpass breast cancer death by 2025. Therefore, finding new therapeutic strategies is of major importance. Recently, myoferlin, a protein overexpressed in pancreatic cancer, has been shown to impact mitochondrial dynamics and respiration. Because myoferlin has been showed to be a potential therapeutic target in PDAC, understanding its function and determining its localization in PDAC is of major importance. We focused our interest on mitochondria-associated membranes (MAMs). [less ▲]

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See detailEnhancing the volatile profile at sub-ambient temperature by using vacuum-assisted HS-SPME. Case study on fish spoilage
Mascrez, Steven ULiege; Psillakis, Elefteria; Purcaro, Giorgia ULiege

Poster (2021, June)

Headspace solid-phase microextraction (HS-SPME) is an easy, effective and selective technique for the analysis of volatiles and semi-volatiles compounds. However, long equilibration time is requested to ... [more ▼]

Headspace solid-phase microextraction (HS-SPME) is an easy, effective and selective technique for the analysis of volatiles and semi-volatiles compounds. However, long equilibration time is requested to reach optimized extraction conditions. Equilibrium is reached faster in agitating or heating the sample. Heating sample increases the extraction kinetics. However, artefact production can be a limitation, especially for matrices sensible to temperature. Beside other strategies to improve extraction kinetics, the use of vacuum has been recently and successfully proposed to speed up the extraction without increasing the temperature. The aim of this work was to investigate and compare the use of Vac-HS-SPME to regular HS-SPME sampling from complex solid food like fish. The performances of Vac-HS-SPME were investigated at different sampling temperatures and times. In the present work, the effects of extraction temperature, sampling time and SPME phase were investigated using traditional one variable at a time approach. A series of compounds, markers of fish spoilage and covering the entire chromatogram, were selected for the comparison. Gas chromatography coupled to a single quadrupole mass spectrometry was used for the final determination. Comparable results were obtained between sampling at 5 °C under vacuum condition and at 40 °C at atmospheric pressure. This work showed that the use of vacuum can be a powerful approach for volatiles sampling in refrigerated foods. [less ▲]

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See detailClassification of olive oil and geographical origin by using a multi-cumulative trapping HS-SPME-GC-MS follow by a novel data handling software
Spadafora, Natasha; Mascrez, Steven ULiege; McGregor, Laura et al

Poster (2021, June)

The sensory attributes of extra virgin olive oil, and in particular specific aroma defects, are officially responsible for oil classification (or declassification) into extra virgin, virgin or lampante ... [more ▼]

The sensory attributes of extra virgin olive oil, and in particular specific aroma defects, are officially responsible for oil classification (or declassification) into extra virgin, virgin or lampante olive oil. Undoubtedly, volatile compounds play a crucial role in defining olive oil sensory quality and research efforts have been dedicated to unravel the composition of this informative fraction, to better understand correlations with quality attributes. The relative distribution of volatiles depends on several parameters (i.e., cultivar, geographical origin, fruit ripeness, processing practices, and storage) meaning the identification of an unequivocal fingerprint correlated to quality and authenticity is a difficult task. Most of these variables contribute towards the intensity and quality of the green and fruity perception, while the presence of defects is mainly due to inappropriate manufacturing practices. Multiple-cumulative trapping headspace-solid-phase microextraction (named MC-SPME) is a powerful technique proven to enhance the level of information on the volatile profile. Shorter cumulative extraction times, using a low volume of sample to avoid headspace saturation proved effective for discriminating between different qualities of olive oil (i.e. extra-virgin, virgin and lampante oil) as well as the different geographical origins among the extra virgin oils. The use of a novel data mining and chemometrics software enabled automatic alignment of chromatograms and extraction of useful information in a simple and straightforward way, supporting the routine application of this approach to corroborate sensory panel analysis. [less ▲]

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See detailIdentification of novel loci associated with human microbiota composition
Latour, Samuel ULiege; Shagam, Lev ULiege; Mariman, Rob ULiege et al

Poster (2021, June)

Our understanding of the factors shaping intestinal microbiome composition has increased significantly during last decade. Host genetics is one of these factors and may explain ~10% of the microbiome ... [more ▼]

Our understanding of the factors shaping intestinal microbiome composition has increased significantly during last decade. Host genetics is one of these factors and may explain ~10% of the microbiome variance . So far, and despite the number of GWAS studies performed to identify loci associated with microbiome composition, only few associations were cross‑replicated. This study makes use of an extensive dataset integrating 300 healthy individuals (CEDAR-1 cohort) from whom we obtained (i) genotype (Illumina Human OmniExpress BeadChip imputed to 6M SNPs with MAF⩾5%) (ii) 16S rRNA based taxonomic assignation for biopsies from the ileum, transverse colon and rectum (3 amplicons mapped to SILVA database). We performed a GWAS (PLINK additive model) to unravel new associations between genotype and microbiota. Our findings were further verified in two confirmation cohorts obtained from residual stool samples collected during colonoscopy (n=295), from ileum, transverse colon and rectum biopsies and stools (CEDAR-2 cohort) (n~ 50 and 20) where we also tested for individual variation regarding sample provenance. We observed that intestinal location explained a small part of the microbiome variability (<1%) in our dataset. The variation in microbial composition explained by the individual effect represents the major fraction (>50%). We identified three association between SNP and bacterium abundance at the experiment-wide p-value threshold (6x10-10). Among these three associations, the second and third were reproduced at nominal p value of 5% in the confirmation cohort. We have identified 2 putative novel loci associated with human microbiome composition . We also showed a strong individual effect on bacterial communities and a low location variability across the intestinal tract. [less ▲]

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See detailExploring the capability of the HiSorb probe for characterization of volatile and semi-volatile compounds in brewed coffee by GCxGC-qMS
Mascrez, Steven ULiege; Eggermont, Damien; Purcaro, Giorgia ULiege

Poster (2021, June)

Volatile and semi-volatile components are highly relevant to characterize different samples, among which food. These compounds contribute to the peculiar aroma profile of foods and are widely used to ... [more ▼]

Volatile and semi-volatile components are highly relevant to characterize different samples, among which food. These compounds contribute to the peculiar aroma profile of foods and are widely used to assess quality and authenticity. The analysis of volatile and semi-volatile compounds requires the sampling of the headspace (HS) above the sample, which, now a day is mainly performed using high-concentration-capacity HS (HCC-HS) approaches, such as solid-phase microextraction (SPME), stir-bar sorptive extraction (SBSE). More recently, HiSorb has been introduced to fill the gap between SPME and SBSE. In fact, it can be easily automated (as for SPME) but present a significantly higher sorbent volume which allows a much higher trapping capacity. The aim of this work was to exploit the potentiality of HiSorb for the analysis of volatile and semi-volatile from brew coffee and compared to the traditional triphasic SPME fiber more widely applied. Time and temperature conditions were carefully optimized, and the possibility of performing multiple cumulative trapping was investigated as well. The analyses were performed on a multidimensional comprehensive gas chromatographic system coupled with a quadrupole mass spectrometer (GC×GC-qMS) and equipped with a Flow modulator. The fingerprinting obtained from a series of different coffee was investigated for quality and authentication purposes. [less ▲]

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See detailCategorization and word extension in children with Developmental Language Disorder
Dauvister, Estelle ULiege; Bastings, Florence ULiege; Maillart, Christelle ULiege

Poster (2021, June)

Background: Word learning difficulties are often part of the deficits presented by children with Developmental Language Disorders (DLD). Word learning is known to be an inference-based processed ... [more ▼]

Background: Word learning difficulties are often part of the deficits presented by children with Developmental Language Disorders (DLD). Word learning is known to be an inference-based processed, constrained by categorization, which helps the extension of new words to unfamiliar entities. These processes appear integrated in Bayesian models of cognition, which offer an interesting approach to explore this phenomenon. Indeed, learning takes place thanks to an inductive inference process that recruits prior knowledge and principles of statistical learning (detection of regularities). Our study aims at (1) defining if children with DLD can draw inductive inferences in a word-learning context using categorization; (2) defining the impact of prior knowledge on categorization tasks, i.e. defining if the task is easier when prior knowledge is available vs not available and exploring the strategies used by children to categorize unfamiliar stimuli. Methods: Thirteen children with DLD (between 6;0 and 9;0) and fifteen age-matched controls were exposed to a word-learning task in which they faced with exemplars of objects associated with pseudo-words. Objects belong to three categories spreading across three hierarchical levels. For each item, children chose among a set of test objects from the same categories which one(s) could be labelled the same (word extension). Our design included two parts: familiar and unfamiliar categories. Results and conclusions: Our results replicated previous work on familiar categories, which showed similar performances for children with and without DLD in a word extension task. However, differences between groups appeared for unfamiliar categories, suggesting difficulty in category-based inference and word extension when prior knowledge is not available to support the inference process of children with DLD. [less ▲]

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See detailMicrobial composition and viability in equine feces after processing for transplantation
Loublier, Clémence ULiege; Heinen, Julia ULiege; Taminiau, Bernard ULiege et al

Poster (2021, June)

Fecal microbiota transplantation has been used empirically for decades in equine medicine but evidence based information on this technique is scarce. This in vitro study aimed to assess the effect of a ... [more ▼]

Fecal microbiota transplantation has been used empirically for decades in equine medicine but evidence based information on this technique is scarce. This in vitro study aimed to assess the effect of a common fecal pre-transplantation processing method on microbiota composition and viability of the fecal inoculum. A fresh equine fecal sample was divided in three 300g aliquots, to be processed identically as follows: feces (T ) were mixed with 1 L of lukewarm water and chopped using an immersion blender to obtain a mixture (T ), which was left uncovered during 30 minutes (T ) and filtered through a sieve to obtain a fecal infusion (T ). Samples were taken at different steps of the procedure (T ) and immediately stored at 4°C < 6 hours until processing. Bacterial 16S rDNA amplicon profiling associated to propidium-monoazide treatment was performed in each of the 12 samples to select living bacteria. Total flora was measured using quantitative PCR analysis. Bacterial community structure, composition and total flora were statistically compared (significance p < 0.05). No significant differences in ecological indices or abundance of the major bacterial genera were identified for the different steps of fecal processing. Estimated total flora (mean ± SD) in the final fecal infusion was not significantly lower (10.06 ± 0.07 log gene copies/g) than in the original manure (10.29 ± 0.3 log gene copies/g). Results were similar for all three fecal aliquots. These results suggest that the processing method described in this study is replicable and the resultant fecal inoculum contains live bacteria and a microbial population similar to the original fecal sample. [less ▲]

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See detailActivational effects of androgens and estrogens can not reverse sex differences in song behavior and the song control nuclei in adult male and female canaries
Barros Dos Santos, Ednei ULiege; Ball, Gregory F; Cornil, Charlotte ULiege et al

Poster (2021, May 29)

Treatments with testosterone (T) do not activate singing behavior nor promote growth of song control nuclei to the same extend in male and female canaries (Serinus canaria). Because T acts in part via ... [more ▼]

Treatments with testosterone (T) do not activate singing behavior nor promote growth of song control nuclei to the same extend in male and female canaries (Serinus canaria). Because T acts in part via aromatization into an estrogen and brain aromatase activity is lower in females than in males, we hypothesized that this enzymatic difference explains the differential response to T in the two sexes. To test this idea, three groups of castrated males and 3 groups of photoregressed females received either 2 empty 10 mm Silastic implants or one empty implant and one implant filled with T or one implant filled with T plus one with estradiol (E2). Songs were recorded and analyzed for 3 hours each week for 6 weeks before brains were collected and song control nuclei volumes were measured in Nissl-stained sections. We confirmed that multiple measures of song were induced more efficiently by T in males than in females. Co-administration of E2 did notimprove these measures and even inhibited some measures such as song rate and song duration. Similarly, the volume of three main song control nuclei (HVC, RA, and Area X) was increased by the two steroid treatments but they remained significantly smaller in females than in males irrespective of the endocrine condition. The lower response of females to T is thus not caused by a lower aromatization of the steroid; sex differences in canaries are probably organized either by early steroid action or by sex-specific gene regulation directly in the brain. [less ▲]

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See detailAre the studies (tests) assessing the efficacy of the treatments of the alcoholdeprivation effect underpowered?
Léonard, François ULiege; Tirelli, Ezio ULiege

Poster (2021, May 28)

While adequate power and sample sizes are indispensable for the detection (by the statistical test) of a meaningful effect size (ES), many published studies in psychology do not describe sample-size ... [more ▼]

While adequate power and sample sizes are indispensable for the detection (by the statistical test) of a meaningful effect size (ES), many published studies in psychology do not describe sample-size calculation (SSC), which weakens the study methodological quality. Omission of SSC is often associated with a lack of prospective power, which exaggerates observed ES and increases the False Report Probability (FRP), thereby jeopardizing results reproducibility. Our purpose is to investigate in which extent this practice concerns the literature assessing the efficacy of the psychological and pharmacological treatments of the alcohol-deprivation effect (operationalized in an animal model). We will firstly select articles published from 1993 to 2020 using the database PubMed and check whether they mention a SSC. We will then classify the articles mentioning a SSC according to five components of a complete description of SSC (ex. power analysis with or without details). We will also check whether the hypothetical ES (used to determine sample sizes) is justified and the observed ES interpreted (discussion). Thereupon, in order to assess a possible ES overestimation in the selected literature, we will examine the relationship between the observed ES and the sample sizes. We will compute the “power-to-detect” of each relevant statistical test using small, medium and large ES (classifications). Finally, we will compute the FRP and the True Discovery Rate using a risk alpha of 1, 2.5 or 5%, the median “power-to-detect” and a representative range of pre-study odds (from 0.01 to 0.99), according to Ioannidis (2005) and Szucs & Ioannidis (2017). [less ▲]

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See detailIdentification of interaction profiles in kindergarten to support language development
Houben, Lauren ULiege; Bouchard, Caroline; Maillart, Christelle ULiege

Poster (2021, May 28)

Optimal language development depends on language experiences of preschool children. In Belgium, 97% of children from 3 to 5 years old attend school most of the day. School has thus a key role in language ... [more ▼]

Optimal language development depends on language experiences of preschool children. In Belgium, 97% of children from 3 to 5 years old attend school most of the day. School has thus a key role in language development, especially for children who have insufficient language experiences at home. Current Belgian and International studies found that language skills are not enough stimulated at school, confirming the need to study variables which influence the language interactions. The quality level of language interaction is influenced by teachers’ characteristics, teachers’ knowledge of language development, self-evaluation of education practices and reported education practices. Considering these inter-individual differences, this research aims to evaluate how to improve language support in preschool classes. For this purpose, we will evaluate the current quality level of language interaction between teachers and children with CLASS PreK tool. From this general level of interaction quality, we will assess whether different interaction profiles emerge among the teachers. Different profiles would indicate different needs in terms of language support. Understanding these individualized needs is essential for the implementation of any professional development. [less ▲]

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See detailReporting quality of the literature on the pharmacological and psychological treatments of the alcohol-deprivation effect
Léonard, François ULiege; Monseur, Christian ULiege; Tirelli, Ezio ULiege

Poster (2021, May 28)

Adequate reporting practices are essential to transparent and reproducible research. A lack of adequate reporting could notably reflect methodological deficiencies, a rampant problem in experimental and ... [more ▼]

Adequate reporting practices are essential to transparent and reproducible research. A lack of adequate reporting could notably reflect methodological deficiencies, a rampant problem in experimental and biological psychology. We assessed the reporting quality in the literature on pharmacological and psychological treatments of alcohol-deprivation effect (ADE), a popular behavioral animal model of alcohol relapse. A literature search on PubMed yielded 154 titles among which we extracted 68 articles meeting the inclusion criteria. We evaluated these articles according the reporting guide ARRIVE 2.0 that comprises 54 items, each of which being coded as properly reported or not. On a 55-point scale (including 0), the median reporting score was 27 [IQR: 24; 29.25]. The articles reporting scores moderately increased from 1993 to 2020, as suggested by a LOWESS regression generated from 100 000 bootstraps, the R² being 0.158 [CI95%: 0.036; 0.316]. This trend was supported by the comparison, using a two-sided Mann-Whitney U test, of the scores derived from the articles published before 2010 (first publication of ARRIVE) and those published after 2012, which resulted in a 9.61% increase with a moderate effect size r of 0.34 [CI95: 0.11; 0.55]. Our results generalize the low quality of reporting practices found in several fields of experimental and biological psychology to the field of ADE. Although we found a measurable and encouraging increase in the quality of reporting, there is still much room for improvement. [less ▲]

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See detailEBP in Belgian clinical psychology
Blause, Sacha ULiege

Poster (2021, May 28)

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See detailThe impact of familiarity, place attachment, distance and social capital on effective urban green space attendance
Noël, Tania ULiege; Dardenne, Benoît ULiege

Poster (2021, May 28)

The numerous benefits linked to the presence of natural spaces in an urban environment are no longer to be demonstrated. However, in order to take advantage of all these benefits, these spaces must be ... [more ▼]

The numerous benefits linked to the presence of natural spaces in an urban environment are no longer to be demonstrated. However, in order to take advantage of all these benefits, these spaces must be used. This study focuses on the different variables that can influence the effective use of urban green space by citizens. The study was conducted as part of a pilot project to fight urban poverty in Seraing, Belgium. In this pilot area, three parks were studied. In order to understand what might influence area residents to attend these green spaces, a theoretical model was developed and tested. Based on the literature, we assume that the more familiar an individual is with the urban green space, the more attached he or she will be to it, which will result in an effective increase in space attendance. However, we assume that the link between familiarity and attachment is influenced by the individual's active involvement in neighborhood life (number of local groups individuals belong to, how many times/month they participate in each of these groups and how involve they are in the decision-making processes). We also assume that the link between attachment and actual use is influenced by the distance between the home and the space. Hypotheses were tested using linear mixed models, given that a single participant could evaluate more than one park. Our results show that, indeed, the more participants (N = 231) are familiar with the evaluated green space, the more they are attached to it, which leads to an increased attendance. Being involved in neighbourhood’s life by local groups memberships positively impacts the familiarity-attachment link. [less ▲]

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See detailThe sense of presence: Validation of a new presence questionnaire
Heck, Michelle ULiege; Wagener, Aurélie ULiege; Simon, Jessica ULiege

Poster (2021, May 28)

Over the past few decades, virtual reality (VR) has become a valuable tool in research and clinical psychology (Riva et al., 2020). The sense of presence is defined as the user’s feeling of being inside ... [more ▼]

Over the past few decades, virtual reality (VR) has become a valuable tool in research and clinical psychology (Riva et al., 2020). The sense of presence is defined as the user’s feeling of being inside the virtual environment and is a key concept of immersion in VR (Diemer et al., 2015). Although several self-reported presence questionnaires already exist, very few of them are validated in French, and generally fail to integrate the assessment of the social aspects induced by the avatars present in the virtual environment. In order to address these issues, the present study aimed at validating a new questionnaire of presence based on Slater’s model (2009) and on Biocca and colleagues’ model (2003). In particular, we based our questionnaire on the assessment of four dimensions of presence: place presence, plausibility presence, social presence and copresence. We developed a 12-item questionnaire and validated it in a VR snowball fight game among 149 participants. Confirmatory factor analysis with four latent variables revealed a good fit of the data to the model (χ2(48)=59.12, p=.13, RMSEA=.39, SRMR=.38; CFI=.99; TLI=.99). Furthermore, we observed good internal consistency (place presence: α =.88, plausibility: α =.92, social presence: α =.80, copresence: α =.70). In conclusion, it seems like this new questionnaire could accurately assess the sense of presence in French-speaking participants. [less ▲]

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See detailThe effects of cognitive load on cognitive fatigue in Multiple Sclerosis - Preliminary results
Guillemin, Camille ULiege; Requier, Florence ULiege; Delvenne, Julie et al

Poster (2021, May 28)

Background. Cognitive fatigue is one of the most frequent and debilitating symptom of Multiple Sclerosis (MS). While it is well established that MS patients show a decrement of performances during ... [more ▼]

Background. Cognitive fatigue is one of the most frequent and debilitating symptom of Multiple Sclerosis (MS). While it is well established that MS patients show a decrement of performances during/following a long cognitive task, only few studies investigated the effects of cognitive load on MS-related fatigue. Objective. To explore the effects of cognitive load on performance decrement and pupil variations in MS. Methods. Thirteen patients with early MS (disease duration <5) and 12 matched healthy subjects performed a dual-task in cognitive load conditions (low and high). High cognitive load was adjusted to individual resources by determining the fastest presentation rate leading to at least 85% accuracy; the low cognitive load condition is 50% slower. Additionally, pupil size variations were obtained during the task for 6 patients and 7 controls. Repeated measures ANOVA were performed to determine the group, time and cognitive load effects on averaged performances and pupil size. Supplementary analysis were conducted on performances using Bayesian statistics. Results. ANOVA on performances revealed an effect of condition (F(1,20)=37.79, p<.0001) and time (F(3,20)=13.32, p<.0001) but no effect of group nor interaction effects. Bayesian statistical analysis revealed an absence of difference in performances’ evolution between groups (BF01=5.71). ANOVA for pupil size revealed a tendency to significance for the group*condition interaction (p=0.077). Discussion. MS patients did not demonstrate larger fatigue effects on performances than control when the task is adapted to individual resources. The lack of pupillary response to cognitive load seems to reflect cognitive fatigue in patients despite behavioral compensation. [less ▲]

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See detailMind Blanking is Associated with a Rigid Spatio-Temporal Profile in Typical Wakefulness
Mortaheb, Sepehr ULiege; Klados, Manousos; Van Calster, Laurens ULiege et al

Poster (2021, May 28)

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See detailSpeakInVR : validation of a virtual audience
Etienne, Elodie ULiege; Leclercq, Anne-Lise ULiege; Remacle, Angélique ULiege et al

Poster (2021, May 28)

Introduction/Context: Nowadays public speaking is a vital skill in many circumstances and in very different fields: the sales representative who presents a product to customers, the manager who defends ... [more ▼]

Introduction/Context: Nowadays public speaking is a vital skill in many circumstances and in very different fields: the sales representative who presents a product to customers, the manager who defends his project in front of stakeholders, the candidate during a job interview, the professor in front of students, etc. However, social anxiety may impede oral presentation performances . Repeated training in front of an audience can help to better control the speaker’s emotions and skills, and improve speaking performances (Wallach et al., 2009). Given that training in front of a real audience can be logistically difficult to organize, virtual reality (VR) can be the solution. Nevertheless, the emotional impact of the virtual audience on the speaker will depend on the emotional valence and arousal they attribute to the audience’s avatars. Aim: The goal of the present study is to assess the emotional valence and arousal attributed to the avatars of a new virtual audience, depending on the avatars’ attitude. Method and material: Based on the methods from Chollet & Scherer (2017), 125 adults participated in this study. They rated the emotional valence and arousal of 8 avatars depending on their body posture, their face’s expressions, or their head movements. Results and conclusions: Results show that head movements were more readily linked to the emotional valence attributed to the avatars by the participants than were body postures and facial expressions. Furthermore, arousal seems to be directly linked with head movements and facial expressions. Full results from each parameter will be discussed. [less ▲]

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See detailValidation of a virtual audience for public speaking: Preliminary results
Menjot, Pauline ULiege; Remacle, Angélique ULiege; Schyns, Michael ULiege et al

Poster (2021, May 28)

Background. Public speaking is one of the most feared activities (Furmark, 2002). Speaker’s anxiety influences their communication performance. While the literature highlights the benefits of public ... [more ▼]

Background. Public speaking is one of the most feared activities (Furmark, 2002). Speaker’s anxiety influences their communication performance. While the literature highlights the benefits of public speaking training, is complex to implement in real -life (Goberman et al., 2011). Hence, virtual reality (VR) could be a viable alternative tool (Owens & Beidel, 2015). The aim of this study was to validate a virtual audience for public speaking by assessing its qualities (i.e., feeling of presence and cybersickness) and its ability to elicit emotional (i.e., anxiety) and behavioral (i.e., dysfluencies) reactions. Methodology. Forty participants without social anxiety (attested to by the PRCS, Heeren et al., 2013 ; LSAS-SR, Heeren et al., 2012 ; and BFNE-S, Rodebaugh et al., 2004) or fluency disorders (confirmed by the SSI-4, Riley, 2009) were recruited. They had to give an oral presentation under three counterbalanced conditions (in an empty virtual conference room and in front of virtual and real audiences). We aimed to analyze their speech and anxiety and the quality of VR. Due to the health crisis, this methodology was only pre-tested on 8 participants. However, positive results, including a sufficient feeling of presence and the lack of cybersickness, suggest that this virtual audience can be a relevant tool. Conclusions. The methodology will be discussed in light of these first positive results, on the one hand, and of the characteristics that can be improved (realism of the virtual audience and methodological limits), on the other hand, for the benefit of future studies. References Furmark, T. (2002). Social phobia: Overview of community surveys. Acta Psychiatrica Scandinavica, 105(2), 84–93. https://doi.org/10.1034/j.1600-0447.2002.1r103.x Goberman, A. M., Hughes, S., & Haydock, T. (2011). Acoustic characteristics of public speaking: Anxiety and practice effects. Speech Communication, 53(6), 867–876. https://doi.org/10.1016/j.specom.2011.02.005 Heeren, A., Ceschi, G., Valentiner, D. P., Dethier, V., & Philippot, P. (2013). Assessing public speaking fear with the short form of the personal report of confidence as a speaker scale: Confirmatory factor analyses among a French-speaking community sample. Neuropsychiatric Disease and Treatment, 9, 609–618. https://doi.org/10.2147/NDT.S43097 Heeren, A., Maurage, P., Rossignol, M., Vanhaelen, M., Peschard, V., Eeckhout, C., & Philippot, P. (2012). Self-report version of the Liebowitz Social Anxiety Scale: Psychometric properties of the French version. Canadian Journal of Behavioural Science, 44(2), 99–107. https://doi.org/10.1037/a0026249 Owens, M. E., & Beidel, D. C. (2015). Can virtual reality effectively elicit distress associated with social anxiety disorder? Journal of Psychopathology and Behavioral Assessment, 37(2), 296–305. https://doi.org/10.1007/s10862-014-9454-x Rodebaugh, T. L., Woods, C. M., Thissen, D. M., Heimberg, R. G., Chambless, D. L., & Rapee, R. M. (2004). More information from fewer questions: The factor structure and item properties of the original and brief Fear of Negative Evaluation Scale. Psychological Assessment, 16(2), 169–181. https://doi.org/10.1037/1040-3590.16.2.169 [less ▲]

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See detailJacoby-Whitehouse illusion from taxonomic and thematic associations in Alzheimer's disease
Demonty, Manon ULiege; Invernizzi, Sandra; Delhaye, Emma ULiege et al

Poster (2021, May 28)

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See detailMeasuring attentional bias in an alcohol-related virtual environment: A feasibility study
Heck, Michelle ULiege; Grogna, David ULiege; Quertemont, Etienne ULiege et al

Poster (2021, May 28)

Substance-relevant cues sometimes become the focus of attention and elicit substance-seeking behavior in the environment. This shift in attention allocation, called “attentional bias”, appears to be due ... [more ▼]

Substance-relevant cues sometimes become the focus of attention and elicit substance-seeking behavior in the environment. This shift in attention allocation, called “attentional bias”, appears to be due to neurobiological and motivational processes leading alcohol-related stimuli to acquire incentive-motivational properties that can trigger craving and consumption (Field & Cox, 2008; Robinson & Berridge, 1993). Attentional biases have typically been assessed using attentional tasks such as the addiction Stroop task (Cox et al., 2006) or the visual probe task (van Hemel-Ruiter et al., 2016), sometimes coupled with eye-tracking devices (Bollen et al., 2020; van Duijvenbode et al., 2017). However, the presentation of one single pair of stimuli or another more or less complex pattern of stimuli cannot be considered an adequate reflection of the complexity of real-life substance use situations (Hertel & Mathews, 2011). To increase the ecological validity of the task, we jointly used an eye-tacking device during the immersion in a virtual environment that includes multiple alcohol-related cues. We investigated the specific cues that may be related to attentional bias during free exploration of an alcohol-related environment. Finally, we investigated whether attentional bias is related to subjective craving and alcohol consumption.To this end, 30 social drinkers were recruited and exposed to a virtual bar. All of them completed a set of questionnaires before and after the virtual experience, including a craving scale. The data actually allowed us to identify the relevant items for the study of attentional biases. [less ▲]

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See detailThe impact of syntactic knowledge on working memory for serial order
Querella, Pauline ULiege; Majerus, Steve ULiege

Poster (2021, May 28)

While a vast number of studies have shown that the retention of item information in verbal working memory (WM) is strongly determined by long-term language knowledge, the interaction between the retention ... [more ▼]

While a vast number of studies have shown that the retention of item information in verbal working memory (WM) is strongly determined by long-term language knowledge, the interaction between the retention of serial order information in WM and verbal long-term is much more controversial. This study explored the impact of syntactic long-term knowledge on serial order retention abilities in WM. We presented to French speaking participants sequences of adjective – noun pairs, with adjectives either preceding or following the noun. The French language is of particular interest here as depending on the type of adjective, the most frequent positional occurrence of an adjective is either before or after the noun. We constructed adjective-noun pair lists that either obeyed to these statistical syntactic rules or that violated these rules. We hypothesized that if serial order recall in WM depends on long-term knowledge, then serial order recall errors should be larger for WM lists including adjective-noun pairs with infrequent/illegal positional arrangement, and serial order migration errors should occur involving positional regularization of the infrequent/illegal adjective-noun pairing. This hypothesis was tested in 120 participants (18-35 years old) who had to memorize and repeat 6-word lists containing each 3 adjective-noun pairs, the pairings following the syntactically most frequent order or not. Data analysis is on-going. [less ▲]

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See detailPower and True Report Probability in the Literature on Mice Nicotine Conditioned Place Preference
Léonard, François ULiege; Tirelli, Ezio ULiege

Poster (2021, May 28)

A lack of prospective power and use of effect sizes in the literature of various fields have been revealed and characterized over the years, giving rise to serious doubts on the reproducibility of many ... [more ▼]

A lack of prospective power and use of effect sizes in the literature of various fields have been revealed and characterized over the years, giving rise to serious doubts on the reproducibility of many scientific results (Button & al. 2013, Nat.Rev.Neurosci. 14:365-376; Cohen 1962, Abnorm.Psychol. 65:145-153). To our knowledge, no study has address this problem in the field of experimental psychopharmacology using animal models. The articles were identified in PubMed. The sample size, the type of statistical test, its result, degrees of freedom and pvalue were recorded. We then computed the individual and the median prospective powers for 6 possible effect sizes (Cohen’s d: 0.01, 0.2, 0.5, 0.8, 1.2, 2). The TRP was computed from the median power, type-I error rate and the plausibility (prior probability). Amongst 139 articles, only 47 met our inclusion criteria for 109 statistical tests. In this sample, 77.57% of tests were significant. The median powers for small (0.2), medium (0.5) and large (0.8) effect sizes in F test were 9.56% [IQR 7.96%-11.5%], 34.45% [IQR 24.61%-47.01%] and 70.46% [IQR 52.92%-85.91%]. None of these numbers reached the recommended minimal prospective power of 80%. A 50% hypothetical plausibility yielded TRPs of 48.9%, 77.5%, and 87.6% for small, medium and large effect sizes. For a plausibility of 10%, the TRP were 16.1%, 40.8% and 58.5%. These results generalize to a subfield of animal-model experimental psychopharmacoloy (nicotine CPP in mice) the lack of power reported in the litterature of several neurobehavioural and psychological disciplines. [less ▲]

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See detailLong term evolution of large scale magnetic structures on USET images
Vanden Broeck, Grégory ULiege

Poster (2021, May 27)

The global dynamics and evolution of large-scale magnetic structures such as sunspots in the photosphere and bright plages in the chromosphere is one of the primary topics of contemporary solar physics ... [more ▼]

The global dynamics and evolution of large-scale magnetic structures such as sunspots in the photosphere and bright plages in the chromosphere is one of the primary topics of contemporary solar physics. Indeed, it can provide unique insights in sub-photospheric processes leading to the production of solar magnetic fields as well as their decay. It can also improve our understanding of the mechanisms that govern the evolution of the global solar irradiance and its impact on the Earth environment. The detailed information that can be obtained from solar images also provides a unique key to infer the properties of equivalent magnetic activity phenomena in myriads of distant stars. [less ▲]

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See detailThe irradiation-induced renal ischemic preconditioning is blunted by the oral administration of the anti-angiogenic agent, Sunitinib
Khbouz, Badr ULiege; LALLEMAND, François ULiege; Rowart, Pascal ULiege et al

Poster (2021, May 27)

● Objective: Irradiation has been suggested to induce renal ischemic preconditioning (RIP) in mice, possibly via angiogenesis. First, we comprehensively investigate the pathways involved in kidneys ... [more ▼]

● Objective: Irradiation has been suggested to induce renal ischemic preconditioning (RIP) in mice, possibly via angiogenesis. First, we comprehensively investigate the pathways involved in kidneys-centered irradiation. Next, we assess the functional impact of renal irradiation applied before renal ischemia/reperfusion (I/R) injury. Finally, we test whether Sunitinib-mediated inhibition of the angiogenesis prevents irradiation-associated RIP. ● Methods: Exp1: Renal irradiation (8.56 Gy) was performed in male C57bl/6 mice (n=10). One month later, total kidney RNA was extracted from irradiated and control (n=5) mice for comparative RNA-Seq. Exp2: After renal irradiation, the right kidneys were removed, and the left kidneys undergo ischemia(30min)/reperfusion(48h) at Days 7-14-28 post irradiation (n=8). Exp3: Following the same protocol of I/R at Day14, 3 groups were compared (n=8): 1/irradiation; 2/irradiation and gavage with Sunitinib from Day2 to 13; 3/control group without irradiation or gavage. ● Results: Exp1: RNA-Seq showed up-regulation of angiogenesis signaling pathways. Expressions of angiogenesis markers (CD31, VEGF) showed an increase at both mRNA and protein levels in irradiated kidneys (p<0.01). Exp2: Following I/R, BUN and SCr levels were lower in the irradiated mice compared to controls: (BUN: 86.2±6.8 vs. 454.5±27.2mg/dl; SCr: 0.1±0.01 vs. 1.7±0.2mg/dl, p<0.01). The renal infiltration by CD11b (187±32 vs. 477±20/mm²) and F4-80 positive cells (110±22 vs.212±25/mm²) was reduced in the irradiated group. VEGF and CD31, were increased in irradiated kidneys at both mRNA and protein levels (p<0,01). Exp3: One-way analysis of variance followed by Tukey’s test showed that, following I/R, BUN and SCr levels were lower in irradiated group compared to controls (BUN: 106.1±33.6 vs. 352.2±54.3mg/dl; SCr: 0.3±0.13 vs. 1±0.2mg/dl), and in irradiated group compared to the irradiated-exposed group to Sunitinib (BUN: 106.1±33.6 vs. 408.4±54.9mg/dl; SCr: 0.3±0.12 vs. 1.5±0.3mg/dl; p<0.01). ● Conclusions: Kidneys-centered irradiation induces the activation of angiogenesis pathways in mice. Renal irradiation leads to RIP, with preserved renal function and attenuated inflammation post I/R. Exposure to the anti-angiogenic drug Sunitinib post-irradiation prevents the irradiation-induced RIP. [less ▲]

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See detailHuman Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study
Cirillo, Arianna ULiege; Huart, Justine ULiege; Taminiau, Bernard ULiege et al

Poster (2021, May 26)

: Dysbiosis of gut microbiota (GM) has been involved in the pathophysiology of arterial hypertension (HT), via a putative role of short chain fatty acids (SCFAs). Its role in the circadian regulation of ... [more ▼]

: Dysbiosis of gut microbiota (GM) has been involved in the pathophysiology of arterial hypertension (HT), via a putative role of short chain fatty acids (SCFAs). Its role in the circadian regulation of blood pressure (BP), also called “the dipping profile”, has been poorly investigated. Sixteen male volunteers and 10 female partners were subjected to 24 h ambulatory BP monitoring and were categorized in normotensive (NT) versus HT, as well as in dippers versus non-dippers. Nuclear magnetic resonance (NMR)-based metabolomics was performed on stool samples. A 5-year comparative follow-up of BP profiles and stool metabolomes was done in men. Significant correlations between stool metabolome and 24 h mean BP levels were found in both male and female cohorts and in the entire cohort (R2 = 0.72, R2 = 0.79, and R2 = 0.45, respectively). Multivariate analysis discriminated dippers versus non-dippers in both male and female cohorts and in the entire cohort (Q2 = 0.87, Q2 = 0.98, and Q2 = 0.68, respectively). Fecal amounts of acetate, propionate, and butyrate were higher in HT versus NT patients (p = 0.027; p = 0.015 and p = 0.015, respectively), as well as in non-dippers versus dippers (p = 0.027, p = 0.038, and p = 0.036, respectively) in the entire cohort. SCFA levels were significantly different in patients changing of dipping status over the 5-year follow-up. In conclusion, stool metabolome changes upon global and circadian BP profiles in both genders [less ▲]

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See detailCould Bis-THIQ compounds inhibit plasmodial growth through SK channel interaction ?
Taouba, Hossein ULiege; Vitello, Romain ULiege; Lumb, Jean-Philip et al

Poster (2021, May 26)

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See detailQuantification of 2-disulfide bonded isomers of apamin, a peptidic toxin, leads to the observation of a structural rearrangement
Wanko Nembot, Alexis Marius ULiege; Hayen, Jean-Luc ULiege; Vitello, Romain ULiege et al

Poster (2021, May 26)

Apamin (APA1) interacts strongly with SK channels and blocks corresponding SK currents. Apamin is an octadecapeptide with four cysteine residues assembled in two disulfide bridges. In the context of our ... [more ▼]

Apamin (APA1) interacts strongly with SK channels and blocks corresponding SK currents. Apamin is an octadecapeptide with four cysteine residues assembled in two disulfide bridges. In the context of our program related to the development of selective blockers of SK channels, we were interested in assessing the biological activity of two isomers of apamin (APA2 and APA3). These peptides present another disulfide bond connectivity. These peptides were produced by chemical synthesis. Before these biological evaluations, the quantification of peptide content in our samples was needed. Thus, solution of these peptides were analyzed by NMR techniques. [less ▲]

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See detailIN-HOUSE ASSAY SET UP FOR GENOTYPING AND RESISTANCE PROFILE OF HEPATITIS C (HCV) BY SEQUENCING THE NS5B (CENTRAL REGION) AND NS3 USING A SINGLE METHOD
Uwimbabazi, Jean-Claude ULiege; BONTEMS, Sébastien ULiege; HAYETTE, Marie-Pierre ULiege et al

Poster (2021, May 26)

Hepatitis C virus (HCV) infection remains a major public health concern affecting approximately 185 million people worldwide (Childs-Kean, L.M et al.). There is a high variability between circulating ... [more ▼]

Hepatitis C virus (HCV) infection remains a major public health concern affecting approximately 185 million people worldwide (Childs-Kean, L.M et al.). There is a high variability between circulating strains of hepatitis C virus. This variability determines and influences the response and duration of treatment (Petruzziello, A. et al.). Currently, there is limited data available on the HCV viral strains in Rwanda and there is no systematic laboratory genotyping and sequencing tools for optimal management of patients in the country. The purpose of this work is to develop and set up an in-house method within the Clinical Microbiology Laboratory in the CHU-Liege that allow simultaneous genotyping and Direct acting antivirals (DAAs) resistance profiling by direct sequencing the HCV NS3 and NS5B genes which is applicable to a wide range of genotypes. The developed tool will be subsequently transferred to Rwanda. This will aid in determining the HCV genotype among infected patients; ascertaining the epidemiological surveillance of circulating strains in Rwanda; and help in monitoring of patients under antiviral treatment in various health care facilities. The first objective was to validate the detection and identification of the common circulating HCV genotypes 1-6 using in-lab developed or literature cited primes. The second objective was to evaluate the sensitivity of the method and its capacity to monitor resistance of HCV to antiviral treatment especially to DAAs currently used in various clinical settings; and finally, to analyze clinical samples from patients routinely followed up in CHU of Liege. [less ▲]

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See detailRoot Apical Meristem ionic and transcriptomic response to Zinc excess stress
Thiébaut, Noémie ULiege; Richtmann, Ludwig; Ranjan, Alok et al

Poster (2021, May 26)

Exploitation of previously industrialized soils is a challenge complicated by the presence of pollutants left by different activities. Among these pollutants, high metallic concentration is strongly ... [more ▼]

Exploitation of previously industrialized soils is a challenge complicated by the presence of pollutants left by different activities. Among these pollutants, high metallic concentration is strongly affecting the plants growth, and limits the possibilities of site exploitation for agricultural or even ecological purpose. One promising solution for valorization of the soils is phytoremediation. Several species, classed as hyper-accumulative plants, can grow on these polluted soils and actively extract toxic metals and store them in their aerial parts. For instance, some Arabidopsis halleri populations accumulate zinc in its aerial parts up to a level that would be toxic to any other Arabidopsis spp. Under normal conditions, zinc presence in soil is not detrimental for plants, as it is a necessary micronutrient. However, in these polluted soils, its concentration is often excessive and phytotoxic. Absorption starts in the root system and this system’s length will directly limit the depth of the possible phytoremediation. The primary root growth depends on root tip’s homeostasis, which is regulated by hormones balance, and ROS balance. Zinc excess has been shown to have an effect on auxin production and induce ROS in diverse conditions and species. Moreover, it could have a direct effect on cell cycle phases and on other unexpected processes, as zinc is an essential cofactor to many metalloenzymes, zinc-finger transcription factors and F-box containing proteins. Therefore, Arabidopsis root tips are ideal candidates to further study zinc concentration variation responses. Firstly, a description of the effect on the meristem size and root tip organization has been done. Secondly, an assessment of the zinc concentration in the root tip was conducted by ICP-MS to hypothesize if there is an active exclusion from this mitotically active part. Finally, this question and others were further addressed by a description and comparison between a classical and apical root transcriptomic response. By working with the model species Arabidopsis thaliana, we hope to set the bases to understand the metallic stress’ effect on root growth and physiology. We focus on unravelling the exact physiological effect of zinc on the root tip organization, ionic composition and transcriptomic profile. [less ▲]

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See detailLow frequency high resolution optical inertial sensors
Amorosi, Anthony ULiege; Amez-Droz, Loïc ULiege; Ding, Binlei et al

Poster (2021, May 19)

Nowadays, sensors’ resolution limits their performance at low frequency which reduces their operating range. Sensors with a good resolution at low frequency are required to improve the performance of ... [more ▼]

Nowadays, sensors’ resolution limits their performance at low frequency which reduces their operating range. Sensors with a good resolution at low frequency are required to improve the performance of gravitational wave detectors in the sub-Hz frequency range. We are currently developing an inertial sensor with a sufficient resolution at low frequency from 10 mHz to 100 Hz. We are focusing on the improvement of different characteristics of the sensor, among others, its compactness and its thermal noise mitigation. The readout consists of a long-range Michelson interferometer fed by a 1550 nm laser and whose signal is measured by InGaS photodetectors. The use of InGaS photodetector in our interferometer will allow better resolution for future sensor projects. The inertial mass is connected to the frame by a fused silica flexure joint to limit internal damping. Then, translational guidance is implemented to allow the use of a flat mirror. The actual sensor developed at the Precision Mechatronics Laboratory has a resolution of 2x10^(-13) m/√Hz at 1 Hz. Our goal is to reach the same resolution with a compact version: 10x10x10 cm^3. [less ▲]

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See detailRevealing the acoustic range of the biophony of a coastal reef environment : distances of detection, distances of propagation and human impact
Raick, Xavier ULiege; Di Iorio, Lucia; Gervaise, Cédric et al

Poster (2021, May 18)

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See detailL’appartement virtuel comme outil prometteur pour l’investigation de la mémoire épisodique
Billet, Maud; Willems, Sylvie ULiege

Poster (2021, May 10)

Les tests classiques de mémoire épisodique sont très éloignés de ce que nous vivons dans la vie quotidienne et de nos connaissances actuelles sur la ME. Les environnements virtuels offrent la possibilité ... [more ▼]

Les tests classiques de mémoire épisodique sont très éloignés de ce que nous vivons dans la vie quotidienne et de nos connaissances actuelles sur la ME. Les environnements virtuels offrent la possibilité de créer une expérience personnelle contrôlée et naturaliste. Ils ont donc été considérés comme une solution pour augmenter la validité écologique et théorique de nos mesures de la ME. L'objectif de cette étude était d'explorer, dans trois groupes d'âge, la qualité des souvenirs épisodiques créés précédemment lors d'une série d'actions réalisées dans un appartement virtuel (AV). Méthodes. La navigation dans le AV a été réalisée par 60 participants (20 par groupe d'âge : 20-39 ; 40-59 ; 60-79). Un scénario était proposé permettant un encodage incident et un parcours standardisé dans cet AV immersif. Les participants devaient ensuite se souvenir d'autant d’actions réalisées que possible que possible - avec des informations concernant les actions réalisées, les détails perceptifs, spatiaux, temporels et les pensées ou émotions. Les participants ont ensuite rempli une série de tests de mémoire classiques (CVLT, RBMT-III), un questionnaire d’auto-évaluation de la mémoire (PRMQ), et différents tests évaluant les fonctions exécutives (Stroop, Trail Making Test). Résultats. Une analyse de comparaison de corrélations indique que l’auto-évaluation de la mémoire par questionnaire est significativement plus corrélée avec les souvenirs des actions réalisées en AV qu'avec les scores du CVLT ou même du RBMT-III aux tests classiques. L'âge et les fonctions exécutives ont un impact sur la quantité et la qualité des détails contextuels associés à chaque action rappelée. Alors que le sentiment de vivacité associé aux souvenirs chez les jeunes participants est associé à la quantité de détails spatiaux rappelés, ils sont davantage associés aux pensées et aux émotions chez les participants plus âgés. Discussion. Ces résultats semblent cohérents avec les études précédentes et s'ajoutent à la littérature croissante entourant l'intérêt de l’utilisation de la réalité virtuelle pour l'évaluation de la mémoire épisodique. [less ▲]

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See detailMössbauer spectroscopy studies of Fe-based electrode material for Li-ion and Na-ion batteries
Mahmoud, Abdelfattah ULiege; Bodart, Jérôme ULiege; Karegeya, Claude ULiege et al

Poster (2021, May 05)

Batteries have become essential in tackling global warming and energy security. In 2019, the developers behind the Lithium-ion batteries (LIBs) were awarded the Nobel Prize for chemistry. LIB by having ... [more ▼]

Batteries have become essential in tackling global warming and energy security. In 2019, the developers behind the Lithium-ion batteries (LIBs) were awarded the Nobel Prize for chemistry. LIB by having the highest energy density of any such device is considered as the battery of choice for electric vehicles and large-scale smart grids [1, 2]. However, LIBs cannot stand alone to fulfill future needs; therefore, it is urgent to develop new energy storage devices with high safety, lower cost, and high energy density to realize mobiles and large-scale applications. Na-ion batteries (NIBs) are considered to be an alternative to Li-ion batteries owing to the natural abundance of sodium. Indeed, NIBs are expected to become part of the mix of technologies that will meet the challenges of energy storage. Electrode materials are the most important components in the operation and the performance of LIBs and NiBs. New electrode materials are required to increase the energy density of Li/Na-ion batteries. Iron-based materials with non-toxic metals are good candidates to search for new high-performance electrodes [3, 4, 5]. Indeed, Fe-phosphate-based electrode materials for LIBs and NIBs have been intensively investigated to evaluate the electrochemical performance. Mössbauer spectroscopy has been used as a powerful tool to investigate the local electronic and structural properties and to elucidate the reaction mechanisms during the electrochemical cycling of the electrode materials for LIBs and NIBs. Indeed, Mössbauer spectroscopy technique could provide a lot of information about the local environment of atoms through electric and magnetic interactions. In this poster, we will show from some selected examples how Mössbauer spectroscopy when used with X-ray diffraction can help to improve the performance of electrode materials for Li/Na-ion batteries. References: 1- J. Światowska, P. Barboux, Elsevier, (2015), pp. 125-166. 2- A. Mahmoud, I. Saadoune, P.-E. Lippens, M. Chamas, R. Hakkou, J.M. Amarilla, Solid State Ionics, 300 (2017), pp. 175-181 3- T. Jungers, A. Mahmoud, C. Malherbe, F. Boschini, B. Vertruyen, Journal Materials Chemistry, A, 7 (2019), pp. 8226-8233. 4- R. Essehli, A. Alkhateeb, A. Mahmoud, F. Boschini, H. Ben Yahia, R. Amin, I. Belharouak, Journal of Power Sources, 469 (2020), pp. 228417. 5- C. Karegeya, A. Mahmoud, F. Hatert, R. Cloots, B. Vertruyen, P. E. Lippens, F. Boschini, Solid State Ionics, 326 (2018), pp. 18-26. Acknowledgment: The authors would like to kindly thank Walloon Region for the financial support. [less ▲]

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See detailMulti-Cumulative Trapping HS-SPME to enhance the volatile profile of extra-virgin olive oil
Mascrez, Steven ULiege; Purcaro, Giorgia ULiege

Poster (2021, May)

This work explores the capability of multiple-cumulative trapping (MC) SPME on the characterization of the aroma profiling of olive oils, exploiting the automation capability of a novel headspace ... [more ▼]

This work explores the capability of multiple-cumulative trapping (MC) SPME on the characterization of the aroma profiling of olive oils, exploiting the automation capability of a novel headspace autosampler. The theory that underlays this extraction technique is based on the equilibrium among a three-phase system, i.e., sample-headspace-fiber. A compromise between sensitivity and extraction time is usually needed to optimize the sample throughput, mainly when a large number of samples are analyzed, as usually the case in cross-samples studies. Moreover, contrary to what is usually applied, the selection of the sample volume which does not saturate the headspace (i.e. even 10 times lower than the commonly used quantity), is of high relevance in order to maximize the information extractable. In this work, the fingerprinting of olive oil is explored to discriminate among extra virgin, virgin, and lampante oil, a challenging task of interest for quality and authenticity assessment. The different conditions were compared, considering the general information as pattern analysis, rather than intensity-wise. [less ▲]

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See detailImpact des facteurs climatiques sur le nombre de cas annuel de myopathie atypique
Stern, David ULiege; Fettweis, Xavier ULiege; François, Anne-Christine ULiege et al

Poster (2021, May)

La myopathie atypique est une intoxication saisonnière résultant de l’ingestion des samares (à l’automne) ou de plantules (au printemps) de l’érable sycomore (Acer pseudoplatanus). Des conditions ... [more ▼]

La myopathie atypique est une intoxication saisonnière résultant de l’ingestion des samares (à l’automne) ou de plantules (au printemps) de l’érable sycomore (Acer pseudoplatanus). Des conditions météorologiques particulières ont été associées à l’émergence de séries cliniques de cette maladie. L’objectif de cette étude est d’identifier les facteurs climatiques contribuant à expliquer la variation du nombre de cas de myopathie atypique par année et par saison, en Belgique et en France Des cas sont survenus sur l’ensemble du territoire franco-belge mais l’incidence de la maladie est plus élevée dans les provinces de Liège, Namur et Luxembourg pour la Belgique et en Champagne-Ardenne et Picardie pour la France. Les gelées printanières tardives et un faible taux de précipitations estivales semblent impacter le risque de déclarations à l’automne suivant alors que les grands vents automnaux contribueraient à initier les grandes séries de cas. Aux facteurs climatiques viennent s’ajouter au risque d’intoxication d’autres paramètres, tels que la présence d’érables sycomores et leur densité, la gestion des pâtures, des équidés, ou encore l’éveil du secteur à la nécessité de déclarer la maladie et de documenter les cas. [less ▲]

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See detailElectrochromic Nanomaterials Based on Hybrid Molybdenum-Tungsten Oxide: Synthesis, Wet Coating and Structural / Optoelectronic Characterizations
Gillissen, Florian ULiege; Maho, Anthony ULiege; Manceriu, Laura ULiege et al

Poster (2021, May)

Hybrid Molybdenum-Tungsten oxides nanomaterials are obtained by solvothermal synthesis. In comparaison with undoped WO3-x, a boost in the optical signature has been observed, which can be linked to a ... [more ▼]

Hybrid Molybdenum-Tungsten oxides nanomaterials are obtained by solvothermal synthesis. In comparaison with undoped WO3-x, a boost in the optical signature has been observed, which can be linked to a concentration increase of reduced species and oxygen vacancies in the material. The « MoWOx » powder is then wet-processed as thin film by spin coating and succesfully used as plasmonic EC material, dispalying a selective and independent modulation of both visible and NIR wavelengths as a function of the applied potential. [less ▲]

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See detailTemporal and Spatial Variation in Domestic Water Consumption: The Case of Wallonia, Belgium
Nguyen, Bich Ngoc ULiege; Teller, Jacques ULiege

Poster (2021, May)

Understanding factors influencing water consumption is vital for water utilities and policymakers to predict future demand accurately. Using Wallonia as a case study, mixed effect models were developed ... [more ▼]

Understanding factors influencing water consumption is vital for water utilities and policymakers to predict future demand accurately. Using Wallonia as a case study, mixed effect models were developed and validated to study the temporal and spatial variation in residential water consumption. Results confirmed the importance of household size, income, alternative sources of water, and dwelling characteristics (such as living area and garden) in explaining residential water demand. Additionally, an annual constant drop of 1.5% was observed for household water consumption from 2009 to 2018 in Wallonia. After controlling for these key factors, the location of the household still possesses a marginal, though significant, effect on water consumption. [less ▲]

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Peer Reviewed
See detailPersistent organic pollutants in feathers of the Greater rhea (Rhea americana), a near-threatened flightless bird of the Pampas grasslands
Lèche, Alvina; Gismondi, Eric ULiege; Martella, Monica B. et al

Poster (2021, May)

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See detailMercury toxicity on biomarker gene expressions of a freshwater amphipod at two temperatures
Melo, Madson; Gismondi, Eric ULiege

Poster (2021, May)

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See detailA rapid and efficient method for dialkyl ketones and sterols determination in fat
Mascrez, Steven ULiege; Danthine, Sabine ULiege; Purcaro, Giorgia ULiege

Poster (2021, May)

The present work deals with the optimization of a fast method for the determination of dialkyl ketones (DAKs) in interesterified fats. Microwave-assisted saponification was optimized, followed by ... [more ▼]

The present work deals with the optimization of a fast method for the determination of dialkyl ketones (DAKs) in interesterified fats. Microwave-assisted saponification was optimized, followed by purification on a lab-packed silica solid-phase extraction (SPE) cartridge. The method proposed may be used for the determination of DAKs or both DAKs and sterols by simply eluting an additional fraction from the SPE cartridge. The final determination was performed by gas chromatography- flame ionization detector (GC-FID) for quantification and gas chromatography-mass spectrometry (GC-MS) for confirmation purposes. The proposed method showed good recoveries (>80%) and limit of quantification (0.04-0.07 μg/g for the 4 standard DAKs and of 0.07 μg/g for α-cholestanol). Repeatabilities (n=3) were below 15% for DAKs and generally lower than 6% for sterols. Accuracy on the entire sterol profile was confirmed in comparison to the International Olive Council reference method. The method was finally applied to real-world samples before and after chemical interesterification. [less ▲]

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See detailThe role of cows on OVOC exchanges of a pasture
Heinesch, Bernard ULiege; Michel, Colin; Amelynck, Crist et al

Poster (2021, April 29)

The presence of cows on a pasture considerably modifies exchanges of biogenic volatile organic compounds (BVOCs). By regulating the biomass present, they can have an impact on the constitutive flux ... [more ▼]

The presence of cows on a pasture considerably modifies exchanges of biogenic volatile organic compounds (BVOCs). By regulating the biomass present, they can have an impact on the constitutive flux (exchanges from soil and grass that are not induced by leaf wounding or trampling by cows) but they can also cause direct emissions from exhalation and indirect emissions by leaf injury (grazing), trampling and wastes. In this study conducted on the ICOS pasture site of Dorinne (Belgium), we disentangled these different sources/sinks for three oxygenated BVOCs commonly exchanged on grasslands (methanol, acetaldehyde and acetone), using a combination of turbulent flux measurements, enclosure flux measurements, tools to detect the presence and activity of cows in the footprint of the turbulent flux measurements and a flux footprint model. Direct exhalation emissions were low, representing only 2.3% and 10% of the spring total flux of methanol and acetone respectively. Comparison of grazed and non-grazed enclosures pointed out that emissions following leaf wounding were significant for all studied BVOCs, decreased exponentially with time to become negligible after maximum five days. Cow indirect emissions at the pasture scale (turbulent flux measurements) where likely dominated by grazing and were shown to be a major component of the total diurnal flux for each of the three studied BVOCs. Comparison with a hay meadow also showed that the temporal dynamics of those BVOC emissions were very different according to the grass management type, calling for specific parametrization in up-scaling emission models. [less ▲]

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See detailImproving the representation of cropland sites in the Community Land Model (CLM) version 5.0
Boas, Theresa; Bogena, Heye; Grünwald, Thomas et al

Poster (2021, April 28)

The incorporation of a comprehensive crop module in land surface models offers the possibility to study the effect of agricultural land use and land management changes on the terrestrial water, energy and ... [more ▼]

The incorporation of a comprehensive crop module in land surface models offers the possibility to study the effect of agricultural land use and land management changes on the terrestrial water, energy and biogeochemical cycles. It may help to improve the simulation of biogeophysical and biogeochemical processes on regional and global scales in the framework of climate and land use change. In this study, the performance of the crop module of the Community Land Model version 5 (CLM5) was evaluated at point scale with site specific field data focussing on the simulation of seasonal and inter-annual variations in crop growth, planting and harvesting cycles, and crop yields as well as water, energy and carbon fluxes. In order to better represent agricultural sites, the model was modified by (1) implementing the winter wheat subroutines after Lu et al. (2017) in CLM5; (2) implementing plant specific parameters for sugar beet, potatoes and winter wheat, thereby adding the two crop functional types (CFT) for sugar beet and potatoes to the list of actively managed crops in CLM5; (3) introducing a cover cropping subroutine that allows multiple crop types on the same column within one year. The latter modification allows the simulation of cropping during winter months before usual cash crop planting begins in spring, which is an agricultural management technique with a long history that is regaining popularity to reduce erosion and improve soil health and carbon storage and is commonly used in the regions evaluated in this study. We compared simulation results with field data and found that both the new crop specific parameterization, as well as the winter wheat subroutines, led to a significant simulation improvement in terms of energy fluxes (RMSE reduction for latent and sensible heat by up to 57 % and 59 %, respectively), leaf area index (LAI), net ecosystem exchange and crop yield (up to 87 % improvement in winter wheat yield prediction) compared with default model results. The cover cropping subroutine yielded a substantial improvement in representation of field conditions after harvest of the main cash crop (winter season) in terms of LAI magnitudes and seasonal cycle of LAI, and latent heat flux (reduction of winter time RMSE for latent heat flux by 42 %). Our modifications significantly improved model simulations and should therefore be applied in future studies with CLM5 to improve regional yield predictions and to better understand large-scale impacts of agricultural management on carbon, water and energy fluxes. [less ▲]

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See detailMeta-analysis of some risk factors affecting somatic cell score in dairy cattle
Grayaa, Siwar ULiege; GRAYAA, Marwa; Jemmali, Bayrem et al

Poster (2021, April 26)

Mastitis and milk quality in dairy cows are an ongoing concern of great relevance to animal welfare and productivity in modern dairy production. High somatic cell scores (SCS) are an indirect measure of ... [more ▼]

Mastitis and milk quality in dairy cows are an ongoing concern of great relevance to animal welfare and productivity in modern dairy production. High somatic cell scores (SCS) are an indirect measure of presence of mastitis and low milk quality, they are relatively easy to record and values of heritability are higher than records of mastitis. However, published SCS values are highly variable across studies which makes it impossible to have a reliable reference value. The objectives of this study are to perform a meta-analysis (1) to estimate this reference value and the extent of its variability and (2) to identify whether and how factors of variation (year and country of publication, parity, and breed) influenced this value. Information on SCS was retrieved from 138 papers published between 1979 and 2020 in 40 countries and analyzed with the Metafor package in R software. Standard deviations were estimated from available data or imputed using a Bayesian hierarchical modelling approach. Results of the meta-analysis revealed a significant decrease of 0.04 units in mean SCS with the year of publication, an increase with the number of parities and a significant variability across countries. The reference SCS value was estimated at 3.68 (3.59 - 3.76) and total heterogeneity across studies at 1.24 (1.11-1.38). Further analyses are necessary to verify arguments provided to explain the results. [less ▲]

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See detail3D distinct element back-analysis (static and dynamic) of a reconstructed rock slope
Mreyen, Anne-Sophie ULiege; Cauchie, Léna ULiege; Havenith, Hans-Balder ULiege

Poster (2021, April 26)

To better comprehend mechanisms at the origin of natural slope failures, a vast number of potential slope weakening and failure triggering factors ought to be considered. Especially for rather ancient ... [more ▼]

To better comprehend mechanisms at the origin of natural slope failures, a vast number of potential slope weakening and failure triggering factors ought to be considered. Especially for rather ancient slope failures, such factors can be difficult to identify and strongly depend on the regional to local climatic as well as seismo-tectonic context. An example of such ancient failure of unknown origin is the Balta rockslide that is located in the seismic region of Vrancea-Buzau, Romanian Carpathians. Even though more superficial landslides are found abundantly in the studied valley, the Balta failure stands out in terms of magnitude and observed geomorphological markers (profound detachment scarp, debris mass accumulation). During the last years, the Balta rockslide has been intensively studied with geophysical measurements (seismic and electrical methods) in order to characterise the landslide and in-situ rock material as well as the extensive dimension of the failure (with an estimated volume of 28.5-33.5 million m³). In this work, we show the results of a numerical back-analysis of the Balta rockslide based on its reconstructed slope topography, implemented with 3D geomodelling, and on prior established geophysical and geomorphological studies; the reconstruction was furthermore conditioned by the morphology of neighbouring slopes in order to better constrain related uncertainties. The structural aspect of the anti-dip bedding of the sandstone dominated flysch slope was remodelled with 40° dipping discontinuities, while 55° dipping crossing discontinuities represent the main joint family observed in the field. The back-analysis was performed with the 3D distinct element code 3DEC (version 5.2, developed by Itasca) and aims at both, understanding static factors affecting slope stability, as well as the behaviour of the pre-failure slope if subjected to dynamic loading by using a synthetic Ricker multiplier as well as real earthquake acceleration data. The actual slope shape in its post-failure state could be approximated after 120 seconds of ground acceleration and is highlighted by lateral spreading of debris mass as well as towards the valley; the latter supposedly caused a temporary landslide dam formation, and possibly accounts for the river diversion observed in the field. This numerical approach furthermore allows us to outline the main controlling factors during seismic slope excitation that are predominated by topographic and structural site effects. [less ▲]

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See detailSelecting directed cycles: a polyhedral study
Baratto, Marie ULiege; Crama, Yves ULiege

Poster (2021, April 20)

Given a directed graph G, a cycle selection is a subset of arcs of G forming a union of directed cycles. When the arcs are weighted, the Maximum Weighted Cycle Selection (MWCS) problem consists in finding ... [more ▼]

Given a directed graph G, a cycle selection is a subset of arcs of G forming a union of directed cycles. When the arcs are weighted, the Maximum Weighted Cycle Selection (MWCS) problem consists in finding a cycle selection of maximum total weight. These definitions are motivated by an application to the kidney exchange problem where patients are incompatible with their associated donor, but can possibly receive a kidney from another donor. Given many such patient/donor pairs, various matching algorithms can be used to maximize the number of feasible transplants by finding exchange cycles in appropriately defined compatibility digraphs. One of the remaining issues is that the actual compatibility between a donor and a patient can only be completely tested after an intended transplant cycle has been identified. Hence, incompatibilities may reveal themselves a posteriori and some exchange cycles turn out not be implementable. A way to tackle this issue is to first select a subset of arcs to be tested, and then to run a matching algorithm. A better understanding of the cycle selection problem may help to address the first step of this procedure. In our study, we focus on the cycle selection problem associated with a complete digraph. First, we establish that MWCS is strongly NP-hard. Next, we provide four complete ILP formulations of the problem: a "natural" one, featuring an exponential number of constraints which can be separated in polynomial time, one extended non compact formulation and two extended compact ones. We investigate the relative strength of these formulations. We next concentrate on the natural formulation and on the description of the associated selection polytope. We prove that it is full-dimensional, and that all the inequalities used in the IP formulation are facet-defining. Furthermore, we describe three new classes of facet-defining inequalities. Then, we numerically test the proposed ILP formulation of MWCS. Despite the theoretical complexity of the problem, the ILP formulation is very quickly solved for many random instances. We also study the problem when we include an additional constraint on the cardinality of a cycle selection. Most of the results proved for the original case remain valid, but numerical tests show that the ILP formulation of the constrained variant is harder to solve. [less ▲]

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See detailSupercritical CO2 foaming of PCL covalent networks—taking benefit from the thermoreversible Diels–Alder cycloaddition
Houbben, Maxime ULiege; Jérôme, Christine ULiege

Poster (2021, April 19)

Foams are versatile materials encountered in our daily life for a wide variety of uses such as cushioning, thermal and acoustic insulation or medical applications. The combination of the mixed properties ... [more ▼]

Foams are versatile materials encountered in our daily life for a wide variety of uses such as cushioning, thermal and acoustic insulation or medical applications. The combination of the mixed properties between a continuous matrix and gas cells and the diversity of pore structures represent a powerful tool for the design of new materials. Among the different polymer foam fabrication processes, the use of supercritical CO2 has been one of the most investigated in the past decade. Nevertheless, the design of crosslinked polymer foams with high foaming ratio still remains a challenge. Various crosslinking processes mainly based on heating, irradiation with the addition of an external agent have been applied after foaming but remain difficult to perform due to mass transfer issues of the crosslinking agent. When crosslinking occurs before foaming, it dramatically limits the material expansion. In order to overcome these drawbacks, the present work aims taking advantage of the thermoreversible Diels-Alder cycloaddition to elaborate foams of poly(ε-caprolactone) (PCL) covalent networks. Based on this reaction, we considered to induce cross-linking after the foam expansion by playing on the thermal equilibrium of the thermoreversible Diels-Alder cycloaddition. Therefore, low molar mass star-shape PCL end-capped by furan or maleimide were impregnated with CO2 under supercritical conditions and then foamed under appropriate control of the pressure and temperature. The resulting foam possesses a much higher volume expansion than a pre-crosslinked sample foamed in the same conditions, thanks to the low crosslinking ratio during foaming. These foams exhibit also improved thermal stability thanks to its chemical crosslinking as compared to non-crosslinked PCL foams. Interestingly, these foams possess shape memory properties due to the semi-crystallinity of the PCL. Thermal stability and shape memory properties were evaluated by dynamic mechanical analysis in both tensile and compression testing with controlled force mode, stress and temperature ramps. Since significant maleimide/furan adduct cycloreversion can be achieved at high temperature, system reversibility and recyclability have also been attested. This foaming process proves itself very interesting by the formation of highly physically expanded and recyclable crosslinked foams from a non-initially foamable material. This contribution aims at reporting a new concept that can be used for the preparation of highly expanded and crosslinked polymers foams from any semi-crystalline polymers. [less ▲]

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See detailRecyclable porous Ionic liquid catalysts from one-pot emulsion templating multicomponent polymerization
Stiernet, Pierre ULiege; Aqil, Abdelhafid ULiege; Debuigne, Antoine ULiege

Poster (2021, April 19)

Porous poly(ionic liquid)s (PILs) combine the intrinsic features of ionic liquids (ILs) with properties of polymers and porous structures notably enlarged surface area, high ionic density, spatial ... [more ▼]

Porous poly(ionic liquid)s (PILs) combine the intrinsic features of ionic liquids (ILs) with properties of polymers and porous structures notably enlarged surface area, high ionic density, spatial structuration, and the tunability of their properties via counterions exchange. Over the years, they have become essential materials for many applications, i.e., gas separation, CO2 capture, energy storage, polymer electrolyte in Li-batteries, sensors and catalysis. Amongst them, porous poly(imidazolium)s (PIMs) are of great interest for cutting edge applications, especially for heterogenous catalysis. Their chemical composition catalyzes a wide range of reactions while their macrostructure allows easy recyclability without the need of advanced purification methods. However, structuring PIMs into porous materials is not trivial and requires multistep approaches based on the polymerization of preformed imidazolium monomers or by post-modification of porous organic networks. Therefore, the search for simpler and straightforward synthesis of porous PILs is highly relevant. In this respect, the emergence of multicomponent reactions (MCR), in which three or more compounds react and form a product containing essentially all atoms of the starting reagents, offers new opportunities. This communication aims at reporting a straightforward and atom economical approach for designing interconnected macroporous imidazolium-based networks. The latter combines for the first time the aqueous mediated Radziszewski MCR under high internal phase emulsion (HIPE) conditions. The catalytic activity and recyclability of these materials are illustrated for transesterification and decarboxylation reactions [less ▲]

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See detailc-Jun and RBM39 co-regulate alternative splicing induced by chemotherapy compounds
Lemaitre, Florence ULiege

Poster (2021, April 15)

Cisplatin-based chemotherapy remains frequently used to treat a wide range of solid tumors, but intrinsic and acquired resistance too often limit the success of the treatment. DNA damage-related ... [more ▼]

Cisplatin-based chemotherapy remains frequently used to treat a wide range of solid tumors, but intrinsic and acquired resistance too often limit the success of the treatment. DNA damage-related alternative splicing (AS) profoundly affects the transcriptome. Given AS involvement in cisplatin-induced cellular responses, identify key regulators in cisplatin-induced AS could lead to new target therapeutic approaches. In this work, we used the exclusion of exons 4-5 of COASY, a robust event detected in cisplatin-treated cells, as reporter. An siRNA screening targeting 56 RNA binding proteins identified RBM39 as a positive regulator of this event in non-treated cells. Following cisplatin treatment, RBM39 depletion enhances exons 4-5 skipping, while c-JUN (known to bind to RBM39) depletion reduced it. We observed by immunoprecipitation and gPCA that the interaction between c-JUN and RBM39 was cisplatin-dependent and RNA-/DNA-independent. Importantly, c-JUN TAD phosphorylation, essential for AP-1 transcriptional activity, was not required to control spliceosome specificity. These observations, combined with the reduced recruitment of RBM39 on COASY transcripts in cisplatin-treated cells, led us to hypothesize a moonlighting role of c-JUN, where it controls the spliceosome specificity independently of its transcriptional potential via direct binding to RBM39. Transcriptome analysis in MCF7 cells depleted in c-Jun or RBM39, treated or not by cisplatin, identified hundreds of skipped exons induced by cisplatin in control cells dependent of RBM39. Among these events 80% were reduced when c-JUN was downregulated suggesting a large-scale regulation mechanism of the spliceosome by these proteins. Functionally, COASYΔE4-5 downregulation modifies the mitochondrial ultrastructure. [less ▲]

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See detailSex and the (Old) City: Knowledge and attitudes toward later life sexuality in a French-speaking sample
Cismaru Inescu, Adina ULiege; Hahaut, Bastien ULiege; Kempeneers, Philippe ULiege et al

Poster (2021, April 15)

The higher life expectancy of the global population and more years lived in better health, confront us to matters that have to be addressed, such as sexual needs in older age. The French translation of ... [more ▼]

The higher life expectancy of the global population and more years lived in better health, confront us to matters that have to be addressed, such as sexual needs in older age. The French translation of Aging Sexual Knowledge Attitudes Scale (ASKAS) was tested on 492 people, aged 18-97. Results show more permissive attitudes among sexually active participants and higher knowledge in the oldest group. More awareness is needed to get better aging sexual knowledge and fight ageist stereotypes. [less ▲]

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