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See detailCustomer-Perceived Intimacy through the Design of Healthscapes
Martens, Carmen ULiege; Delcourt, Cécile ULiege; Herssens, Jasmien

Poster (2019, July)

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See detailComparative Study of Reduced Order Modeling Techniques Applied to Geometrically Nonlinear Structures
Delhez, Elise ULiege; Nyssen, Florence; Batailly, Alain et al

Poster (2019, June)

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Peer Reviewed
See detailiMAX nerve excitability study in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy
Puma, A; Benoit, J; Grecu, N et al

Poster (2019, February 08)

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See detailA new insight into β-lactam resistance in enterococci
Raymackers, Alice ULiege; Verlaine, Olivier ULiege; Amoroso, Ana Maria ULiege et al

Poster (2019, February 07)

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See detailZinc excess and the cell cycle control in Arabidopsis sp.
Thiébaut, Noémie ULiege; Zarattini, Marco; Verbruggen, Nathalie et al

Poster (2019, February 07)

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See detailCharacterization of fermentation pathways and their interaction with photosynthesis in different microalgae
Gain, Gwenaëlle ULiege; Berne, Nicolas; Remacle, Claire ULiege et al

Poster (2019, February 07)

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See detailCharakterisierung der Fluiddynamik und des Stofftransports von wässrigen Zweiphasensystemen (ATPS) in einer flüssig-flüssig Gegenstromextraktionskolonne
Meyer, Christian; Schmidt, Markus; Eggert, Armin et al

Poster (2019, February 07)

Wässrige Zweiphasensysteme (ATPS) werden z.B. durch die Lösung eines hydrophilen Polymers und eines Salzes in Wasser gebildet. Sie bieten im Gegensatz zu organisch-wässrigen Systemen schonende ... [more ▼]

Wässrige Zweiphasensysteme (ATPS) werden z.B. durch die Lösung eines hydrophilen Polymers und eines Salzes in Wasser gebildet. Sie bieten im Gegensatz zu organisch-wässrigen Systemen schonende Umgebungsbedingungen für die Extraktion von Proteinen. [1] Dennoch geht der Einsatz von ATPS selten über die Anwendung im Labor hinaus. Dies liegt zum einen am Aufwand ein passendes Extraktionssystem auszuwählen, zum anderen an den hohen Anforderungen an die apparative Umsetzung aufgrund ihrer extremen physikalischen Eigenschaften wie geringe Dichtedifferenz und Grenzflächenspannung. [2] Zur Überprüfung der technischen Umsetzbarkeit im kontinuierlichen Betrieb wurden flüssig-flüssig Extraktionsversuche in einer vollständig temperierten DN32 Extraktionskolonne mit gerührten Einbauten durchgeführt. Ausgewählt wurde ein Stoffsystem mit Polyethylenglykol und Phosphat als Phasenbildner und Albumin als Übergangskomponente, für das zunächst die Mischungslücke in Abhängigkeit des pH-Werts und der Verteilungskoeffizient bestimmt wurden. Das ATPS wurde anschließend in der Kolonne hinsichtlich der Fluiddynamik und des Stoffaustauschs untersucht. Die Einflüsse der Flüssigkeitsbelastung, des Volumenstromverhältnisses und der Rührerdrehzahl auf die Betriebsgrenze und die Trennleistung, wurden vermessen und werden im Rahmen des Posters präsentiert. Der kontinuierliche Betrieb von ATPS in einer Gegenstromextraktionskolonne wurde erfolgreich realisiert und bei einer aktiven Höhe von 1575 mm bereits mehr als 2 theoretische Trennstufen erreicht. [1] Albertsson, P.-Å., 1986: Partition of cell particles and macromolecules (3. ed.). New York. Wiley [2] Rosa, P. A. J. et al., 2010: Aqueous two-phase systems: A viable platform in the manufacturing of biopharmaceuticals. J Chromatogr A, 1217 (16), 2296–2305 [less ▲]

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See detailArabidopside interactions with plant membranes
Genva, Manon ULiege; Deleu, Magali ULiege; Andersson, Mats X. et al

Poster (2019, February 04)

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See detailRole of FOXM1 in mRNA decay
Mariavelle, Emeline ULiege

Poster (2019, February 01)

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See detailPhospho-Dependant Regulation Of TFIP11 Splicing Factor
Hanache, Sarah ULiege; Duchemin, Amandine ULiege; Peixoto, Paul et al

Poster (2019, February 01)

Pre-mRNA splicing is a fundamental process in mammalian gene expression contributing to protein diversity. Eukaryotic genes are alternatively spliced by the spliceosome, a large conserved machinery ... [more ▼]

Pre-mRNA splicing is a fundamental process in mammalian gene expression contributing to protein diversity. Eukaryotic genes are alternatively spliced by the spliceosome, a large conserved machinery complex comprising RNA, five small nuclear ribonucleoprotein particles (snRNPs: U1, U2, U4, U5 and U6) and around 200 proteins and splicing factors. These splicing factors are frequently phosphorylated by kinases. Such phosphorylation regulates their subcellular localization and interactions with target transcripts and protein partners, and thus regulates splicing reactions. Our lab demonstrated that the splicing factor TFIP11 controls cancer cell-cycle progression by regulating splicing of a specific subset of pre-mRNA (see A.Duchemin abstract). We and others have demonstrated that TFIP11 is highly phosphorylated. This phosphorylation might be critical for its nuclear localization, transport and/or its interaction with RNA or proteins such as DHX15. So, the present project is divided into three main goals: 1) Identification of kinases regulating phosphorylation of TFIP11 2) Identification of phospho-residues of TFIP11 and 3) Impact of phosphorylation on TFIP11 activity. Phosphoproteomic analyses have shown that at least 4 serine residues (S59, S96, S98, S210) and 2 tyrosine residues (Y162, Y722) on TFIP11 undergo phosphorylation. Interestingly, some of these potential phospho-residues are within functional TFIP11 domains including G-Patch domain, nuclear localization signal (NLS) and nuclear speckle targeting sites (NSTS) and belong to consensus sites for CK2 and Prp4K, two kinases known to regulate the activity of splicing factors. Immunofluorescence experiments demonstrated that CK2 and Prp4K colocalize with TFIP11 in the nuclear speckles. Co-immunoprecipitation experiments and/or proximity ligation assay (PLA) demonstrate that TFIP11, CK2 and Prp4K were associated in the same complex. Interestingly, we identified EFTUD2 as an interacting partner of TFIP11 and it seems that EFTUD2 coordinates the same splicing program as TFIP11. Finally, preliminary PLA data show that CK2 inhibition increases the interaction between TFIP11 and EFTUD2, suggesting that a CK2-dependent phosphorylation of TFP11 might be important to regulate its interaction with partner protein EFTUD2. Further investigations are ongoing to determine the functional role of the TFIP11-EFTUD2-CK2 complex in the regulation of the splicing program. [less ▲]

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See detailOptimisation of a surface enhanced Raman scattering method using design of experiments and Bayesian design space modelling
Deidda, Riccardo ULiege; Avohou, Tonakpon Hermane ULiege; Kasemiire, Alice ULiege et al

Poster (2019, January 30)

1 Introduction Surface enhanced Raman scattering (SERS) is an alternative technique based on Raman spectroscopy, which has been increasingly applied to pharmaceutical analytical chemistry in the last ... [more ▼]

1 Introduction Surface enhanced Raman scattering (SERS) is an alternative technique based on Raman spectroscopy, which has been increasingly applied to pharmaceutical analytical chemistry in the last decade. It consists in enhancing the Raman effect by performing analyses using metallic surfaces, such as silver and gold colloids, on which the target molecules are adsorbed to be detected. It has been observed that in this way, an enhancement factor of 103-106 times can be obtained and the lack of sensibility related to conventional Raman scattering overcome [1]. Nowadays, design of experiment (DoE) is widely employed for modelling phenomena in analytical method development and optimisation, especially in the context of separation techniques. It is a structured approach that allows correlating key responses to controllable variables. Ideally, a certain number of factors may affect the critical method attributes (CMAs) of an analytical process in a negative or positive way. These factors are named critical method parameters (CMPs). DoE is employed, as a chemometric tool, to individuate CMPs and then, deeply study how they affect the process under study. To do so, CMAs are linked to CMPs by a regression model built by means of multivariate linear or partial least squares regression. Generally, the designs can be classified in two categories: screening and optimization designs. The formers are generally implemented when a high number of parameters are supposed to influence the analytical process and no much prior information is available. They result in useful tools to study the effects of both continuous and discontinuous factors. Instead, the optimisation designs are principally used to study wisely selected continuous factors [2]. The design space (DS) is defined as a multidimensional area in which the specifications given to the CMAs are met with a defined level of probability. Obviously, the larger the DS is, the more robust the method is. Its computation is achieved by several approaches, such as Monte-Carlo simulations, Bayesian methods as well as bootstrapping techniques [3]. The aim of this project was to combine and apply two potent chemometric tools such as DoE and Bayesian DS to SERS method development and optimisation. 2 Material and methods Gold nanoparticles (AuNPs) were synthesised by using the method described by Lee-Meisel [4]. SERS measurements were performed with a LabRAM HR Evolution Raman microscope (Horiba Jobin-Yvon, Lyon, France), equipped with a 785 nm laser (50mW on the sample) and a two-dimensional EMCCD detector (1600 x 200 pixels sensor). Furthermore, the measurements were carried out with a 300 gr/mm grating and the laser light was focussed on the sample through a 50 x LWD objective. The data were acquired in the 350-1750 cm-1 range. The confocal slit-hole, the exposition time and number of repetitions were fixed at 200 µm, 3 s and 3, respectively. JMP® software was used to generate the experimental plans applied to screening and optimisation as well as for data treatment. A user-written code was used in RStudio® to compute the Bayesian DSs and for their graphical representations. 3 Results and discussion The first step was the definition of the analytical target profile, in other words the purpose of the method. It was defined as the optimal detection, in terms of band intensity linked to the Raman enhancement, of one characteristic band of crystal violet. The latter was chosen as analyte because it presents some characteristic bands that respond very well to Raman analysis and then it can be easily used as a model compound to develop SERS methods. The intensity of the band at ~ 1170 cm-1 was selected as CMA to be directly linked to the mathematical model. The screening design was built by taking into consideration two factors. The typology of aggregation agent (AA type) was studied as categorical factor at 11 levels, while the concentration of aggregation agent (AA conc) was chosen as continuous factor. The data treatment showed that five aggregation agents exhibited a strong positive effect in the augmentation of the band intensity and thus were selected to be more deeply investigated, while the others were directly rejected. The study went on with a first optimisation plan where the factor AA type were estimated at five levels while the AA conc at three levels. A new factor was added: the typology of solvent (SV type) used to dissolve and dilute the analyte during the sample preparation step. This categorical factor was studied at two levels. The first optimisation rapidly led to the selection of two AA types which showed to be most suitable: one for the first SV type (water) and the other for the second SV type (methanol). The optimum zone in terms of AA conc was not found, so a second optimisation was carried out allowing defining it. Lastly, an I-optimal design was applied to optimise the entire analysis process and to integrate the information gained in the previous steps. The DSs, one for each SV type, were computed using a Bayesian approach to consider the uncertainty of the model. 4 Conclusion DoE-DS methodology was successfully applied to SERS method development and optimisation. This structured approach allowed the definition of a working area for which a probabilistic guarantee of success, in terms of satisfaction of CMA specifications, was defined. This study also opens the way for the application of the analytical quality by design (AQbD) to SERS methods. 5 References [1] Cailletaud, J., De Bleye, C., Dumont, E., Sacré, P.-Y., Netchacovitch, L., Gut, Y., Boiret, M., Ginot, Y.-M., Hubert, P., Ziemons, E., Critical review of surface-enhanced Raman spectroscopy applications in the pharmaceutical field. J. Pharm. Biomed. Anal. 147, 458-472, 2018. [2] Sahu, P.K., Ramisetti, N.R., Cecchi, T., Swain, S., Patro, C.S., Panda, J., An overview of experimental design in HPLC method development and validation, J. Pharm. Biomed. Anal. 147, 590-611, 2018. [3] Deidda, R., Orlandini, S., Hubert, P., Hubert, C., Risk-based approach for method development in pharmaceutical quality control context: A critical review. J. Pharm. Biomed. Anal. 161, 110-121, 2018. [4] Lee, P.C., Meisel, D., Adsorption and surface-enhanced Raman of dyes on silver and gold sols. J. Phys. Chem. 86, 3391-3395, 1982. [less ▲]

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Peer Reviewed
See detailIdentification of a new isolate of Banana mild mosaic virus by high throughput sequencing triggers the development of a new diagnostic primer
Hanafi, Marwa ULiege; Rong, Wei ULiege; Crew, kathy S et al

Poster (2019, January 27)

The Bioversity International Musa Germplasm Transit Centre (ITC) hosts more than 1,500 accessions covering the genetic diversity of the genus Musa. Its objective is to conserve this diversity and supply ... [more ▼]

The Bioversity International Musa Germplasm Transit Centre (ITC) hosts more than 1,500 accessions covering the genetic diversity of the genus Musa. Its objective is to conserve this diversity and supply plant materials to users worldwide. These accessions can be distributed only if virus infection is not detected during indexing. The indexing is carried out by targeted IC-(RT)-PCR for 10 viruses, electron microscopy and symptom observation (De Clerck et al., 2017). One accession (ITC 0763) tested negative by IC-RT-PCR while viral particles were observed by electron microscopy, suggesting the infection by a new virus species or by a divergent viral strain from an existing species. The accession was sequenced as follows: after RNA extraction, the sequencing library was prepared using the Ribo-Zero™ Plant Leaf Kit (Illumina) for ribodepletion followed by the TruSeq Stranded Total RNA Library Prep Kit (Illumina). The sample was sequenced on the Illumina Nextseq 500 platform (Liège University) and a total of 8,683,460 paired reads (2x150 nt) were obtained. Bioinformatics analysis was carried out using Geneious v9.1 software. The nearly complete genome sequence of a banana mild mosaic virus (BanMMV) isolate was identified. The primers used for the detection of BanMMV during indexing at Gembloux Agro-Bio Tech are Poty1 and BanMMCP2 (De Clerck et al., 2017). A careful analysis of the genome sequences complementary to the detection primers revealed four mismatches with BanMMCP2 primer. These mismatches could be the origin of the negative PCR results obtained. To confirm this hypothesis, a new primer was designed at the same genome location as BanMMCP2 but with two additional degenerate bases. Combined with Poty1, the new primer was able to detect the infection by BanMMV. Currently, a retrospective analysis is being carried out on all the banana accessions already indexed to validate the new degenerate primer for use in routine indexing. [less ▲]

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See detailDéclin des scores d'empathie chez les étudiants en médecine : est-ce grave docteur ?
Triffaux, Jean-Marc ULiege; Tisseron, Serge; Nasello, Julian ULiege

Poster (2019, January 23)

Objectives. – Empathy is central in patient-physician interactions and understanding its development is decisive for education. However, scientific literatures report a striking decline of empathy among ... [more ▼]

Objectives. – Empathy is central in patient-physician interactions and understanding its development is decisive for education. However, scientific literatures report a striking decline of empathy among medical students during their study course. Firstly, we aimed to replicate this result on a Belgian population. Secondly, as well reported by literature, we expected higher empathy scores for women. Lastly, as central, we expected higher empathy levels for medical students than for “control” students (commercial students were used as a control group: social interactions without a curing aspect) at the beginning of their study course, suggesting that empathy drives students to select specific education fields. Methods. – Through a cross-sectional design, we assessed students from medical and commercial edu- cations at different years of study with the Basic Empathy Scale (N = 1602). We compared: (1) empathy scores at different scholar levels for both populations; (2) scores between men and women; (3) empathy scores between medical and commercial students in their first year of study. Results. – As expected, a significant empathy decline was displayed over time for medical students; women reported significant higher empathy scores than men; and, in their first year, medical students presented significant higher empathy scores than commercials. Conclusions. – Replicating the empathy decline on several student populations is crucial, especially by using different tools. This decline is a multi-factorial process that mainly reflects self-representation changes. The empathy gender bias is a strong effect observed in several empathy-linked phenomena. Finally, empathy is not only central but also drives students to select specific education fields. [less ▲]

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See detailDéclin des scores d'empathie chez les étudiants en médecine : est-ce grave docteur ?
Triffaux, Jean-Marc ULiege; Tisseron, Serge; Nasello, Julian ULiege

Poster (2019, January 23)

Objectives. – Empathy is central in patient-physician interactions and understanding its development is decisive for education. However, scientific literatures report a striking decline of empathy among ... [more ▼]

Objectives. – Empathy is central in patient-physician interactions and understanding its development is decisive for education. However, scientific literatures report a striking decline of empathy among medical students during their study course. Firstly, we aimed to replicate this result on a Belgian population. Secondly, as well reported by literature, we expected higher empathy scores for women. Lastly, as central, we expected higher empathy levels for medical students than for “control” students (commercial students were used as a control group: social interactions without a curing aspect) at the beginning of their study course, suggesting that empathy drives students to select specific education fields. Methods. – Through a cross-sectional design, we assessed students from medical and commercial edu- cations at different years of study with the Basic Empathy Scale (N = 1602). We compared: (1) empathy scores at different scholar levels for both populations; (2) scores between men and women; (3) empathy scores between medical and commercial students in their first year of study. Results. – As expected, a significant empathy decline was displayed over time for medical students; women reported significant higher empathy scores than men; and, in their first year, medical students presented significant higher empathy scores than commercials. Conclusions. – Replicating the empathy decline on several student populations is crucial, especially by using different tools. This decline is a multi-factorial process that mainly reflects self-representation changes. The empathy gender bias is a strong effect observed in several empathy-linked phenomena. Finally, empathy is not only central but also drives students to select specific education fields. [less ▲]

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See detailModélisation de l'endommagement de fluage-fatigue d'un alliage de Nickel pour récepteur solaire
Morch, Hélène ULiege; Duchene, Laurent ULiege; Habraken, Anne ULiege

Poster (2019, January 22)

Un modèle élasto-visco-plastique basé sur le modèle de Chaboche a été implémenté afin de modéliser le comportement de tubes en alliage de nickel utilisés dans les centrales solaires à tour. Pour pouvoir ... [more ▼]

Un modèle élasto-visco-plastique basé sur le modèle de Chaboche a été implémenté afin de modéliser le comportement de tubes en alliage de nickel utilisés dans les centrales solaires à tour. Pour pouvoir estimer la durée de vie des tubes, un modèle d’endommagement basé sur les travaux de Lemaitre a également été intégré au code. Ce modèle comprend deux types d’endommagement qui sont cumulés : l’endommagement de fluage, dont l’évolution suit le modèle de Kachanov, et l’endommagement de fatigue dont l’évolution suit le modèle d’endommagement unifié de Lemaitre. Le modèle a été vérifié à partir de données expérimentales issues de la littérature. [less ▲]

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See detailHigh Streptococcus/Lactobacillus Ratio Revealed in Autistic Adult
Razafindralambo, Aurélie; Razafindralambo, Hary ULiege

Poster (2019, January 18)

Autism is today considered as an epidemic disease, owing to the great increase of the number of children diagnosed for this neurodevelopment disorder, 1/150 now against 1/10000 years ago. Individuals ... [more ▼]

Autism is today considered as an epidemic disease, owing to the great increase of the number of children diagnosed for this neurodevelopment disorder, 1/150 now against 1/10000 years ago. Individuals suffering from Autism-Spectrum Disorders (ASDs) are generally characterized by impairment in communication skills, and stereotypical behavior troubles. Incomplete digestion of gluten and casein, leaky gut syndrome and low gastric acid secretion are among autism specific causes. The use of probiotics has been suggested for possible treatment of ASDs because of the existing relationship between gut and mental health [1]. In a recent report case, we have shown the positive effect of the nutritherapy approach for solving digestive troubles in an autistic individual with intolerance to gluten [2], and without pathogenic mutation on main autistic genes (CNTNAP2 and NRXN1). In order to get insight into the gut composition - autism relationship in probiotics for the same person, his microbiota has been analyzed and compared to those of 3 non-autistic members of his nuclear family by using the latest 16S rRNA technology (microzoo analysis, The Netherlands). It has been revealed that the Streptococcus-Lactobacillus ratio was particularly 50 to 1000 times higher in the autistic's gut compared to individuals with normal communication skills. References: [1] Discroll A, Arnold L. E., Williams K., Savidge T. and Hayes C. Probiotics and autism spectrum disorder, In: Trends in Probiotic Applications, Ed. H. Razafindralambo, Studium Press LCC, Houston, TX. 2018, 171-184. [2] Razafindralambo H, Rabetafika H, Razafindralambo A. Nutrition-Based therapeutic approaches for solving autistic digestive troubles. Adv Food Technol Nutr Sci Open J. 2016; 2(3): 88-95. [less ▲]

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See detailLes correspondances de Machiavel et Guichardin au prisme de la textométrie. Enjeux et perspectives
Miesse, Hélène ULiege; Manchio, Corinne; Lasson, Marc

Poster (2019, January 16)

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See detailThe effect of impaired speaker’s voice and noise on children's spoken language processing
Schiller, Isabel ULiege; Morsomme, Dominique ULiege; Kob, Malte et al

Poster (2019, January 11)

Background – Past studies indicate that listening to either impaired voice or against background noise may compromise children’s ability to process spoken language. However, the interaction of both ... [more ▼]

Background – Past studies indicate that listening to either impaired voice or against background noise may compromise children’s ability to process spoken language. However, the interaction of both factors remains largely unknown. Aim – The aim of this study was to investigate single and combined effects of impaired speaker’s voice and noise on spoken language processing in children (aged 5-6). Methods – First-grade primary school children (n = 53) individually performed two listening tasks: A Minimal-Pair Discrimination task assessing speech perception and a Sentence-Picture Matching Task assessing listening comprehension. Speech stimuli were presented in four conditions: (C1) normal voice and no noise, (C2) imitated impaired voice and no noise, (C3) normal voice and speech-shaped noise, and (C4) imitated impaired voice and speech-shaped noise. Task score per condition was calculated as measure of performance. Results – Irrespective of task, children performed significantly lower when stimuli were presented in a combination of impaired voice and noise (C4) as compared to any other condition. The presence of only one adverse factor (C2 or C3) lowered performance in the speech perception task but not the listening comprehension task. Discussion – Results suggest that when processing speech, young school-aged children are highly vulnerable to the combined effect of impaired speaker’s voice and noise. This could be due to increased auditory masking and reduced cognitive capacity available for linguistic processing. With only a single adverse factor present, children seem able to still use semantic or syntactic context cues for correct interpretation. However, performance drops when such cues are unavailable. Conclusion – Favorable listening conditions may be crucial for children’s processing of spoken language and positive learning outcomes. Particularly in the educational context, where listening is affected by voice quality and noise, measures should be taken to enhance the transmission of the speech signal and reduce noise. [less ▲]

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See detailCollapsing hotspots, extinction, and recovery: The evolutionary history of herbivorous reef fishes
Zapfe, Katerina L.; Frederich, Bruno ULiege; Francesco, Santini et al

Poster (2019, January 04)

Herbivorous reef fishes have evolved to occupy a central role in controlling both the distribution of algae and the flow of energy in coral reef food webs. Today, these fauna and the ecosystems they ... [more ▼]

Herbivorous reef fishes have evolved to occupy a central role in controlling both the distribution of algae and the flow of energy in coral reef food webs. Today, these fauna and the ecosystems they maintain have become increasingly threatened by anthropogenic stressors. Developing an understanding of how the diversification dynamics of these lineages responded to historic climatic shifts provides critical insight into the expectations of herbivorous fish diversity under current models of climatic change. We combined molecular, paleontological, and morphological data to assess the diversification dynamics of rabbitfishes (Siganidae) and surgeonfishes (Acanthuridae), two major clades of herbivorous fishes that have been of central ecological importance over the past 50 million years. By combining landmark-based geometric morphometric data of 396 extant and fossil species images with a time-calibrated phylogeny, we found diversification of both clades reflected the expectations of an extinction recovery model following the collapse of the West Tethys Sea. The two groups however exhibit differing tempos of speciation as well as extant morphospace occupancies relative to Eocene species. Our results indicate the viability of multiple evolutionary pathways leading to lineage persistence in the wake of environmental change. However, given modern-day trends in habitat degradation, they also forewarn of future patterns of diversity not dissimilar to those of the post Tethyian collapse favoring fewer, more generalized herbivores on reefs unlike those of the present. [less ▲]

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See detailVirome Analysis of Grapevines in German Vineyards
Zarghani, Shaheen Nourinejhad; Ruiz-Garcia, Ana Belen; Olmos, Antonio et al

Poster (2019, January)

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See detailDevelopment and optimization of a derivatization protocol for phenethylamine compounds using FITC-CE-LIF method
Emonts, Paul ULiege; Dispas, Amandine ULiege; Ninane, Caroline et al

Poster (2018, December 19)

In the framework of the development of an innovative microfluidic system based on capillary electrophoresis separation, we optimized a fluorescein isothiocyanate (FITC) derivatization protocol for Laser ... [more ▼]

In the framework of the development of an innovative microfluidic system based on capillary electrophoresis separation, we optimized a fluorescein isothiocyanate (FITC) derivatization protocol for Laser Induced Fluorescence (LIF) detection. The microfluidic device will present a high sensitivity thanks to the fluorescence detection and an innovative hydrodynamic injection approach. To highlight the analytical performances of this microfluidic system, we will use synthetic cathinones (and some derivatives) as targeted compounds. They present a panel of closely related structures and isobaric compounds. In addition to analytical challenges, this category of drugs is a current topic regarding to public health. Indeed synthetic cathinones were described as the second most frequently seized group of new psychoactive substances in EU in 2016. Moreover some of them are currently sell on internet as bath salts without any legislation. In this context, fast, easy and reliable analytical tools are required to track and quantify these compounds. In the present study, we initiated the optimization of the derivatization of model compounds (phenethylamine family) using FITC. The panel of model analytes includes primary and secondary amino groups to be representative of future real samples. Design of experiments strategy was used to optimize the derivatization protocol in order to reach an easy sample preparation and to maximize the derivatization efficiency. Finally, the CE developed method will be transferred to the microfluidic system. Then separation performances comparison of traditional CE-LIF vs µCE-LIF will allow to highlight the advantages of microfluidics such as the lower amount of sample required, the gain in time and money, the significant decrease of solvent and its compact size. [less ▲]

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See detailStrategies for the study of plant virus-based virus-like particles (VLP) displaying human papillomavirus (HPV) L2 epitope
Yazdani, Razieh; Shams-Bakhsh, Masoud; Thelen, Nicolas ULiege et al

Poster (2018, December 19)

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See detailEcosystem services & biodiversity in Europe: focus on Wallonia
Gerardy, Alexis ULiege; Maebe, Laura ULiege; Bourdouxhe, Axel ULiege et al

Poster (2018, December 18)

Detailed reference viewed: 32 (10 ULiège)
See detailEvolution and development of white stripe patterns in clownfishes (Pomacentridae)
Salis, Pauline; Roux, Natacha; Soulat, Olivier et al

Poster (2018, December 15)

How can we explain the fabulous diversity of color patterns in coral reef fishes? To address this question, we chose to work on the monophyletic group clownfishes. Clownfishes or Amphiprionini tribe ... [more ▼]

How can we explain the fabulous diversity of color patterns in coral reef fishes? To address this question, we chose to work on the monophyletic group clownfishes. Clownfishes or Amphiprionini tribe comprises 30 species that possess a characteristic colour pattern composed of zero to three vertical white stripes over an orange to black body. Here, we wanted to understand the ultimate and proximate causes at the origin of this diversity of colour patterns by combining eco/evo/devo studies. First, we characterized the cellular nature of the white stripe and showed using drug treatment that those cells correspond to iridophores and that they are indispensable to initiate the formation of the colour pattern. Then, we showed that the common ancestor of clownfishes had three vertical white stripes and, during evolution, we observed a successive caudal to rostral losses of stripes. These results suggested a developmental constrain that we highlighted by studying the development of Amphiprion ocellaris (3 white stripes) and Amphiprion frenatus (1 white stripe). Interestingly, the white stripes of A. ocellaris always appear in a rostral to caudal stereotyped sequence during larval to juvenile transition. Surprisingly, whereas A. frenatus has only one stripe at the adult stage, they acquire three white stripes in a same sequential manner as A. ocellaris during larval to juvenile transition. Later on, these stripes disappear caudo-rostrally during the juvenile phase leading to the definitive colour pattern. Remarkably, the reduction of stripe number over ontogeny matches the sequences of stripe losses during evolution, showing that colour pattern diversification among clownfish lineages results from changes in developmental processes. Finally, we provided evidence that the diversity of striped patterns plays a role for species recognition. [less ▲]

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See detailEcological diversification, recent evolution and speciation of Amphipoda in the polar regions: the case study of Eusirus genus
Salabao, Louraine ULiege; Lepoint, Gilles ULiege; Frederich, Bruno ULiege et al

Poster (2018, December 15)

Because of their long history, the polar regions and especially Antarctica are natural laboratories for evolutionary research. The diverse and specialized polar fauna has evolved during millions of years ... [more ▼]

Because of their long history, the polar regions and especially Antarctica are natural laboratories for evolutionary research. The diverse and specialized polar fauna has evolved during millions of years, and has survived past environmental changes including the glaciations. Given that certain parts of the polar regions are among the fastest warming regions on this planet, knowledge on how these organisms managed to survive climate changes in the past can help us to extrapolate to the future. Here, Eusirus amphipods (crustaceans) are chosen as model organisms because they occur on both poles, are very diverse and live in different habitats. Our knowledge on their ecology and biogeography is still very limited although they are an important component of the marine fauna. From the same amphipod specimens, genetic data, morphological data and ecological data (general ecology, trophic ecology) will be acquired. The evolutionary history of Eusirus amphipods will be reconstructed through time with phylogenetic and population genetic methods, and the obtained phylogenies will be used to map morphological and ecological diversity. This will ultimately reveal which evolutionary processes led to the current diversity of Eusirus amphipods, and if speciation events were constant through time or occurred in bursts. This kind of analyses will also test if there has been convergent evolution of Eusirus amphipods in the two polar regions. [less ▲]

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See detailRefugia and ecosystem tolerance in the Southern Ocean
Schön, Isa; Christiansen, Henrik; Danis, Bruno et al

Poster (2018, December 15)

Confronted with fast-paced environmental changes, biota in Antarctic ecosystems are strongly challenged and face three possible outcomes: adaptation, migration or extinction. Past glaciation periods have ... [more ▼]

Confronted with fast-paced environmental changes, biota in Antarctic ecosystems are strongly challenged and face three possible outcomes: adaptation, migration or extinction. Past glaciation periods have already forced marine zoobenthos of the Southern Ocean (SO) into refugia, followed by recolonization when the ice retreated. The collaborative Belgian BRAIN project RECTO, “Refugia and ecosystem tolerance in the Southern Ocean”, will strive at understanding how such past events have driven diversification and adaptation in different animal groups and how these can be applied as proxies to understand the contemporary situation and predict future scenarios. With molecular approaches, RECTO will reconstruct population histories and spatio-temporal features of Pleistocene refugia. The RECTO target taxa include birds, fish, sea stars, bivalves, amphipods, and ostracods. For all RECTO target taxa, the following molecular data will be obtained: (1) mitochondrial COI barcodes, (2) ddRAD data, and (3) mitochondrial genomes. Mitochondrial genomes will be obtained by genome skimming, and long range PCRs. Mitogenomes can improve the unravelling of phylogeographic relationships and dating of evolutionary events and, through comparisons with non-Antarctic taxa, allow to detect cold adaptations. In fish and amphipods, RECTO will also study in a novel phylogenetic framework how morphological diversification and trophic adaptability (estimated by stable isotope data) are interacting with each other and whether ecotypes of selected species have faster modes of evolution. Geographic models on future species and trait distributions based on physiological and energy limits and present and future climate data will be refined and integrated with individual based models for the SO. Finally, scenarios of future dispersal abilities and possible habitat shifts of the RECTO target groups will be developed to infer how the RECTO target species will respond to future climate change. [less ▲]

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See detailStudy of biological harpoon; microstructure of the mantis shrimp raptorial appendage
Delaunois, Yann ULiege; Compère, Philippe ULiege

Poster (2018, December 15)

Mantis shrimps (or Stomatopods) form one of the most surprising crustacean order in earth. Separated from decapods since Cretacean, species composing this group display unique features that makes them ... [more ▼]

Mantis shrimps (or Stomatopods) form one of the most surprising crustacean order in earth. Separated from decapods since Cretacean, species composing this group display unique features that makes them formidable marine benthic predators. In these features can be found the widest visual spectrum, a transformed telson used both as a shield and as a fin, an antennal pallet used as a rudder but also a pair of enhanced predatorial limbs. Two kinds of predatorial limbs exists, dividing mantis shrimps in two groups: smashing limbs used to brake carapaces and to knock out preys and spearing limbs used to impale fishes. Both these limbs are deployed at high speed thanks to their ability to store and release elastic energy and are reinforced to endure impacts. This study will focus on one spearing mantis shrimp, the striped mantis shrimp (Lysiosquillina maculata (Fabritius,1973)) and the cuticle of its raptorial appendage. The main goal is to understand how spines found in this appendage are internally arranged to face the mechanical stress that occurs when harpooning prey. Techniques as optical microscopy and scanning electron microscopy will allow to define how is arranged the cuticle found in the spine. Techniques of micro-analysis will then superimpose composition to the structural information. These analyses highlight a complex assembly of four layers which can’t be directly linked to the classic succession of layers found in arthropods (e.g. endocuticle, exocuticle and epicuticle). These layers were named lamellar layer, parallel layer, soft helicoidal layer and highly mineralised layer. Each of them differs by fibres orientations, mineralisation rate or compositions and they are thought to play precise roles in the mechanical behaviour of the stomatopod spine. [less ▲]

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See detailInterpretatie van het EVRM: 'nationale veiligheid'
Notermans, Pierre ULiege

Poster (2018, December 14)

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See detailStoichiometry in the alluaudite-type Na2Fe2(SO4)3 for Na-ion cathode
Jungers, Thomas ULiege; Vertruyen, Bénédicte ULiege

Poster (2018, December 13)

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See detailSynthesis of Na2FePO4F by spray drying in order to optimise the composition and morphology for Na-ion batteries applications
Bodart, Jérôme ULiege; Violle, Denis; Mahmoud, Abdelfattah ULiege et al

Poster (2018, December 13)

Li-ion batteries are well-developed for numerous applications but the limited resources and expensive price of lithium urge the necessity to find a viable alternative to lithium. Na-ion batteries are ... [more ▼]

Li-ion batteries are well-developed for numerous applications but the limited resources and expensive price of lithium urge the necessity to find a viable alternative to lithium. Na-ion batteries are considered as a good alternative to Li-ion batteries due to the abundance and well-distributed presence of sodium on earth crust. It is then necessary to develop new electrode material for sodium batteries, with low cost, high energy density and long cycling life. This work presents the synthesis of Na2FePO4F by spray-drying method. In order to compensate the low conductivity of phosphate based materials, carbon nanotubes (CNT) are added during the preparation of the precursor solution. The solution/suspension is spray-dried to obtain a composite precursor and after calcination the desired phase. The spray-drying technique is appropriate to variate the morphology and to control it by modifying the injection parameters (Pressure, temperature, flow rate, injection nozzle). The addition of carbon nanotubes lead to an undesired reduction of the iron to the metallic state. To resolve this problem, the concentration of carbon was modified until no metallic iron remained in the composition. In the present work, two methodology of injection are compared to study their influence on the phase purity, size and morphology of the particles as well as their electrochemical properties. X-ray diffraction is used to verify the crystallinity and the purity of the phase obtained. The results show that a pure phase is obtained in optimized condition and samples with low amount of impurities like Fe2O3 are obianed when no optimization is done. The oxidation state of Fe in the samples, the nature of the impurities and the quantities are confirmed by Mossbauer spectroscopy. During calcination, we observed a phenomenon of carbothermal reduction which was evidenced by Mossbauer spectroscopy (Figure 1). SEM analysis shows the morphology of the obtained particles with a size range between 1,5𝜇m and 8𝜇m using bi-fluid and rotary nozzles, respectively. The electrochemical performances are tested by galvanostatic cycling in sodium half cells and show significant improvement with the optimization of morphology and carbon content. [less ▲]

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See detailAdopting rainfall threshold analysis for landslides in Central Africa using satellite rainfall estimates
Monsieurs, Elise ULiege; Dewitte, Olivier; Kirschbaum, Dalia et al

Poster (2018, December 11)

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See detailFlying through a Dawn Storm : an analysis of Juno-UVS images during PJ11
Bonfond, Bertrand ULiege; Gladstone, G. R.; Grodent, Denis ULiege et al

Poster (2018, December 11)

Auroral dawn storms at Jupiter are spectacular brightenings of the dawn arc of the main emission. These events are relatively rare, but they account for some of the brightest aurorae ever observed at ... [more ▼]

Auroral dawn storms at Jupiter are spectacular brightenings of the dawn arc of the main emission. These events are relatively rare, but they account for some of the brightest aurorae ever observed at Jupiter. An event with a total power emitted by the UV aurora in excess of 8.5 TW was even observed by Hisaki and the Hubble Space Telescope on May 21st 2016, during Juno’s approach of Jupiter. On February 7th 2018 (perijove 11, or PJ11), Juno’s ultraviolet imaging spectrograph, called Juno-UVS, observed the development of such a dawn storm, right before Juno flew right through the magnetic field line connected to this feature. The storm started around 13:15 UT as a limited enhancement of the main emission around midnight before slowly migrating and expanding on the dusk flank. As the brightness increased, the arc began to thicken and fork into two separate arcs. Simultaneously, the signatures of methane absorption of the UV light progressively intensified, indicative of a precipitation of increasingly energetic particles. Then, around 18:15 UT, Juno entered the field lines feeding the dawn storm. The remote auroral observations thus provide extremely valuable context information for the in-situ radio waves, particle and magnetic field observations gathered at this time. [less ▲]

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See detailAnalytic methods for the Abel transform of exponential functions describing planetary and cometary atmospheres.
Hubert, Benoît ULiege; Munhoven, Guy ULiege; Opitom, Cyrielle et al

Poster (2018, December 11)

Remote sensing of planetary and cometary atmosphere is one of the most important source of data and knowledge of the gas layers surrounding the celestial objects of our solar system, including our own ... [more ▼]

Remote sensing of planetary and cometary atmosphere is one of the most important source of data and knowledge of the gas layers surrounding the celestial objects of our solar system, including our own planet. Most of the instruments used up to now and that will be used in a near future study the emission of radiations directly produced by the atmosphere. Under optically thin conditions, this observation method provides the local volume emission rate (VER) originating from the atmosphere, integrated along the full line of sight (l.o.s.) of the instrument. Under a spherical or cylindrical symmetry assumption, the l.o.s. integration of the VER takes the form of the Abel transform of the vertical VER profile. The simplest analytical functions representing VER profiles in real planetary and cometary atmosphere include an exponential function of the altitude (or radial distance), giving the isothermal profile for a planet and the Haser model for a coma. The Abel transform of these functions can be computed analytically using combinations of special functions. Retrieving the vertical (radial) profile of the VER does however require to invert the observed Abel transform to account for possible departures from these idealized analytical expressions, so that indefinite integrals defined from the Abel integral (which we will call indefinite Abel transforms) are needed (or numerical integrations need to be performed). In this study, we present a new method to produce a workable series development allowing accurate computation of the indefinite Abel transforms that appear in the study of optically thin emissions of planetary and cometary atmospheres. Indeed, taking the Taylor series development of the exponential function to reduce the problem to a series of indefinite Abel transforms of polynomial functions (which can be carried analytically) does not work. It leads to the computation of the difference of large, nearly equal numbers, which cannot be done accurately. Our method rather relies on an appropriate series development of the Jacobian of the Abel transform. We show that the computation can be done reliably up to near machine precision, and that accuracy control can be enforced for tailored applications. Possible applications are considered, that include the study of comas and of the upper atmosphere of Mars and the Earth [less ▲]

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See detailTailored films and biomaterials: another reality
Mahy, Julien ULiege; Wolfs, Cédric ULiege; Tilkin, Rémi ULiege et al

Poster (2018, December 10)

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See detailSurface modification of biodegradable microcarriers and their characterization by microscopy
Rocca, Coralie ULiege; Sevrin, Chantal ULiege; Grysan, Patrick et al

Poster (2018, December 10)

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See detailTRUE2: unveiling the nature of true Seyfert 2 candidates through optical polarimetry
Agis-Gonzalez, Beatriz ULiege; Hutsemekers, Damien ULiege; Acosta Pulido, Jose et al

Poster (2018, December 10)

The so-called true Seyfert 2 candidates [1] are Seyferts galaxies whose optical spectra do not show broad lines. Yet, in the X-ray domain, they exhibit some characteristic behavior of Seyferts 1 such as ... [more ▼]

The so-called true Seyfert 2 candidates [1] are Seyferts galaxies whose optical spectra do not show broad lines. Yet, in the X-ray domain, they exhibit some characteristic behavior of Seyferts 1 such as lack of X-ray obscuration and/or short timescale variability. A true Seyfert 2 candidate will be confirmed as a true Seyfert 2 galaxy if the lack of the broad line region (BLR) emission is not only observational but physical. Since the BLR is hidden behind the circumnuclear, optically-thick, dusty torus, only polar-scattered light can probe the presence or absence of the BLR. Hence, scattering-induced polarization is the only way to probe the existence of hidden-BLRs (HBLR). [less ▲]

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See detailCosmology with type Ia supernovae : the ultraviolet 'catastroph'? Evolution with redshift of type Ia supernovae in the ultraviolet domain
Hauret, Clémentine ULiege; Magain, Pierre ULiege

Poster (2018, December 07)

To extract useful cosmological information from type Ia supernovae (SNe Ia), standardization laws have to be determined and applied assuming that these objects do not intrinsically change with redshift ... [more ▼]

To extract useful cosmological information from type Ia supernovae (SNe Ia), standardization laws have to be determined and applied assuming that these objects do not intrinsically change with redshift. Recently, to improve that standardization, attention has been drawn towards the SNe Ia UV spectra. This resulted in (what seemed as) the discovery of two subpopulations of objects, grouped by their bluer or redder UV colors. To confirm the existence of these subpopulations, we significantly enlarged the number of studied SNe Ia (going from ~100 to ~700 objects). With such a sample, SNe Ia cannot be separated in two groups anymore but they rather follow a continuum of colors. More critically, we showed that the SNe Ia UV colors display a significant evolution with redshift, resulting in a potentially important impact on subsequent cosmological measurements. [less ▲]

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See detailThe Overseas Regions and the European Union: Historical Background, Rationale and Dynamics within the Scope of the Institutional Conception of European Identity
Niessen, Annie ULiege

Poster (2018, December 07)

European identity is the first condition for a State to be considered eligible to EU membership. Indeed, Article 49 of the Treaty on the European Union, which regulates the application process for EU ... [more ▼]

European identity is the first condition for a State to be considered eligible to EU membership. Indeed, Article 49 of the Treaty on the European Union, which regulates the application process for EU membership, enshrines that a State must be ‘European’, without specifying the meaning(s) attached to such a qualifier. Various interpretations were provided by the EU institutions in the course of enlargements and membership requests. One of these interpretations is illustrated by the integration, or full assimilation, of some overseas regions into the EU because they have retained ties with one of the EU Member States. Despite their remoted geographical position, these regions were indeed integrated – and not merely associated – in the same capacity as the metropolitan regions, which means that the general provisions of the Treaties apply to these overseas regions. In spite of the fact that this specific option has existed since the Treaty of Rome, different legal provisions for integration have applied to these regions, depending on their status within and ties with the motherland. This poster will provide an overview of the history of the integration of overseas regions into the EEC/EU, as well as the rationale and the dynamics (financial, geopolitical, ‘colonial’, …) behind this process, by relying on a few illustrative cases, such as the French overseas regions (Guadeloupe, Mayotte, Réunion …) and the former integrated Algeria and Greenland. The poster will also display the respective legal integration framework of these cases and the possibility to change their integration/association status enabled by Article 227 TFEU. By presenting the various aspects surrounding the relationship between the overseas regions and the European Union, the poster intends to highlight the historical (colonial) interpretation of European identity and how these regions have eventually become part of the institutional conception of European identity. [less ▲]

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See detailTrophic strategies of reef-building corals under contrasted environmental conditions of East Asian Seas
Sturaro, Nicolas ULiege; Hsieh, Yun Li Eric; Liu, Ling-Wen et al

Poster (2018, December 07)

Most reef-building corals can derive nutrition either autotrophically or heterotrophically, which allows them to use diverse trophic pathways (HOULBRÈQUE & FERRIER-PAGÈS, 2009; MUSCATINE, 1980). Therefore ... [more ▼]

Most reef-building corals can derive nutrition either autotrophically or heterotrophically, which allows them to use diverse trophic pathways (HOULBRÈQUE & FERRIER-PAGÈS, 2009; MUSCATINE, 1980). Therefore, when facing environmental changes, these organisms are expected to demonstrate an intrinsic ability to acclimatise through trophic plasticity. Despite the ecological importance of these corals, our understanding of their trophic strategies is currently impaired by a lack of rigorous research approaches; a failure to consider the intraspecific variability of coral species and an oversimplification of the proxies of heterotrophic habits (e.g. corallite diameter) (MADIN et al., 2016). In order to understand how trophic plasticity could allow them to acclimatise, this study proposed to assess the trophic plasticity of morphologically contrasted coral species (e.g. Stylophora pistillata, Porites sp, Isopora palifera). We determined the stable isotope ratios of carbon and nitrogen in the coral host tissues and algal symbionts and compared these in corals inhabiting areas around Taiwan characterised by contrasted temperature (from high to low latitudes) and light levels (from shallow to mesophotic waters). For each area, we evaluated the intraspecific trophic variability by estimating and comparing coral isotopic niches as a proxy for trophic niches. Our results on Stylophora pistillata revealed no overlap of the isotopic niches for the host and symbiont from different locations (unpublished data), suggesting that these coral colonies are supported by different core resources. Moreover, the isotopic niche of higher latitude coral colonies was larger than those from the lower latitudes (unpublished data), highlighting a certain trophic plasticity that may be related to more variable environmental conditions in the higher latitudes. Analyses of additional species and locations will provide essential insights into the trophic strategies of reef-building corals and how these species might adjust their nutrition in response to environmental changes. [less ▲]

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See detailMethodology for the design of climate responsive houses for optimized thermal comfort in Quetta, Pakistan
Mahar, Waqas Ahmed ULiege; Attia, Shady ULiege

Poster (2018, December 07)

A building must be energy-efficient and provide comfortable indoor environment to the residents. The Building Energy Code of Pakistan (BECP) only focuses on commercial buildings. In today’s scenario a ... [more ▼]

A building must be energy-efficient and provide comfortable indoor environment to the residents. The Building Energy Code of Pakistan (BECP) only focuses on commercial buildings. In today’s scenario a standard must include the context and climate considerations. The aim of this study is to improve indoor thermal comfort of free-running houses in Quetta, Pakistan and raise the awareness of builders about climate sensitivity. [less ▲]

Detailed reference viewed: 34 (3 ULiège)
See detailWhat is APECS Belgium?
Brode-Roger, Dina; Christiansen, Henrik; De Maeyer, Lotte et al

Poster (2018, December 07)

The Association of Polar Early Career Scientists (APECS) is an international and interdisciplinary organization for undergraduate and graduate students, postdoctoral researchers, early faculty members ... [more ▼]

The Association of Polar Early Career Scientists (APECS) is an international and interdisciplinary organization for undergraduate and graduate students, postdoctoral researchers, early faculty members, educators and other people with interests in Polar Regions and the wider cryosphere. Its main goals are communication, education, outreach, and assistance to early career scientists. The APECS leadership team is comprised of early career researchers that are interested in and committed to furthering the activities and the future directions of the organisation. Project initiation and management, web-based or in-person events, are carried out by a number of member-initiated working groups and committees made up of both members and mentors. APECS Belgium, the Belgian National Committee of APECS, was founded in 2011 and has organized and participated in many events and activities since; for example: Conference Symposia, Science fair, school visits, workshops, documentary screenings, outreach events and much more. APECS Belgium encourages polar research at the national level by promoting research projects and institutes in the Belgian territory and sharing the fascination of the Poles with other researchers and the community. Every early career scientist based in Belgium with an interest in the Polar Regions is highly encouraged to join us! We also invite people with links to polar education and research to become part of APECS Belgium. For more information, visit our website: www.apecsbelgium.wordpress.com . [less ▲]

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See detailThe M@dnote project. Giving colour to Grey Literature in General Practice. A collaborative GPs knowledge network
Pizzanelli, Miguel; Resnick, Melissa P.; Cardillo, Elena et al

Poster (2018, December 03)

Abstract (397 words) “M@dNotes Project”. Giving colour to Grey Literature in General Practice. A collaborative GPs knowledge network. Sharing the results of research and scientific production is crucial ... [more ▼]

Abstract (397 words) “M@dNotes Project”. Giving colour to Grey Literature in General Practice. A collaborative GPs knowledge network. Sharing the results of research and scientific production is crucial for the survival of all disciplines. Health information is becoming uncertain and powerful economic interests disrupting medical information has triggered a loss of credibility. M@dNotes project (in Spanish NotasL@cas), is the by-product of non-profit collaborative international knowledge network of general practitioners, family physicians, and healthcare workers. One of the aims of this network is to discuss the validity of the information available on sensitive subjects and build a knowledge exchange network inside a community of practice. The project was born because we realized that more than 95% of the postgraduate and pregraduate research/reports/ scholar works (monographic works) to accomplish or finished one part of the training were finally lost and unpublished. Most of them come from interesting "minds" and are interesting topics to improve the applying of evidence in medical healthcare. From this perspective, M@dNotes is a unique local platform to rescue knowledge and support exchange and collaboration. Perhaps is isolated due to the circumstance of being restricted to few countries or a small group of practice. Nevertheless, we are trying to improve our qualifications in order to link M@dNotes to an open access network. It has been created to share different materials excluded from traditional academic publishing and commercial distribution channels: monographic, commented articles, files with references searches. These materials considered “grey literature” are the product of intense learning process and has been produced to achieve a qualification, be presented in a conference or were collected by users spontaneously through the web searches, with a knowledge purpose. Many of them qualified with an appropriate level because were submitted to a peer review or judged by a scientific committee to get an approval. The project includes an indexing method (Q Codes and ICPC) to manage and retrieve the materials received. Q-Codes are intended for indexing Family medicine related documentation jointly with the International Classification of Primary Care (ICPC). The project provides a particular folder to upload and share the documents. A web blog is the dissemination tool or friendly interface to share and retrieve the documents shared in the network. Through a facility in the cloud, it is possible to access an excel file with all the materials shared, codes assigned and the hyperlink to get a pdf file of each material. [less ▲]

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See detailValorization of glycerol: Continuous flow synthesis of value-added oxirane building blocks
Morodo Martinez, Romain ULiege; Gerardy, Romaric ULiege; Monbaliu, Jean-Christophe ULiege

Poster (2018, December)

The progressive depletion of fossil resources and a global environmental awareness stimulates research toward a transition for more sustainable resources. The last three decades have witnessed ... [more ▼]

The progressive depletion of fossil resources and a global environmental awareness stimulates research toward a transition for more sustainable resources. The last three decades have witnessed developments for the valorization of biomass, and various chemicals of industrial interest can nowadays be derived from bioresources. A wide range of specific molecules named “biobased platforms” can be obtained from raw biomass through biotechnological, chemical or physical treatments. These platforms are compounds of low molecular mass and complexity that can be used as potential building blocks for the synthesis of value-added chemicals. Among them, glycerol occupies a special place: it is widely available as a by-product of the biodiesel production and can readily be transformed into a large variety of value-added products. We present herein a synthetic pathway starting from biobased glycerol toward useful oxirane building blocks traditionally produced from petrobased propene. [less ▲]

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See detailSolvent-Free Continuous Flow Synthesis of Cyclic Organic Carbonates Catalyzed by Organic Salts
Gerardy, Romaric ULiege; Estager, Julien; Debecker, Damien P. et al

Poster (2018, December)

Cyclic organic carbonates are prepared under intensified continuous flow conditions from the corresponding 1,2-diols. The process utilizes dimethyl carbonate (DMC) as carbonation reagent and proceeds ... [more ▼]

Cyclic organic carbonates are prepared under intensified continuous flow conditions from the corresponding 1,2-diols. The process utilizes dimethyl carbonate (DMC) as carbonation reagent and proceeds efficiently under solvent-free conditions. Cheap organic salts of the ammonium and phosphonium-types are assessed as homogeneous catalysts for the model carbonation of glycerol. The nature of the anion dramatically influences the catalytic activity, while the nature of the cation is negligible. Under optimized conditions, glycerol carbonate is prepared in 3 min at 180 °C with 3.5 mol% of tetrabutylammonium bromide (TBAB) as catalyst. By contrast to the prior art, the reaction is extended to a wide range of substrates, affording functionalized cyclic organic carbonates in good to excellent yield. The substrate scope notably encompasses biobased starting materials such as glycerol ethers and erythritol-derived diols. On-line NMR is implemented as analytical tool for qualitative real-time monitoring of the process. [less ▲]

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See detailDo diet variations influence body condition of the French Mediterranean planktivorous teleosts?
Chen, Chia-Ting; Banaru, Daniel; Costalago, David et al

Poster (2018, December)

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See detailElaboration de matériaux zéolithiques à partir d'argiles locales: Application au traitement des eaux
Benhebal, Hadj; Kadi, Samir; Lellou, Salima et al

Poster (2018, December)

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See detailModification inorganique d’une argile locale: Application au traitement des eaux
Benhebal, Hadj; Kadi, Samir; Lellou, Salima et al

Poster (2018, December)

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See detailPreparation of ellagic acid derivatives through a total synthesis approach to improve bioavailability.
Degotte, Gilles ULiege; Halleux, Annabelle; Hans, Aurore et al

Poster (2018, December)

Detailed reference viewed: 17 (7 ULiège)
See detailRefugia and ecosystem tolerance in the Southern Ocean
Schön, Isa; Christiansen, Henrik; De Ridder, Chantal et al

Poster (2018, December)

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See detailLa spasticité est-elle un facteur de prédictif de l'état nutritionnel des patients en état de conscience altérée ?
FADEUR, Marjorie ULiege; Ippoliti, Camilla ULiege; MALHERBE, Christian ULiege et al

Poster (2018, November 28)

Introduction et objectif de l’étude La littérature scientifique concernant l’état nutritionnel des patients en état de conscience altérée (ECA) est à l’heure actuelle très pauvre. Le but de cette étude ... [more ▼]

Introduction et objectif de l’étude La littérature scientifique concernant l’état nutritionnel des patients en état de conscience altérée (ECA) est à l’heure actuelle très pauvre. Le but de cette étude prospective observationnelle transversale est d’investiguer la relation entre le profil nutritionnel de ces patients et leur état de conscience. Matériel et Méthodes Nous avons collecté et analysé les données cliniques (état de conscience, spasticité) et nutritionnelles (indice de masse corporelle (IMC), apports nutritionnels, biologie) de 80 patients en état d’éveil non répondant (ENR), en état de conscience minimale (ECM) ou en état de conscience minimale émergeant (EECM). Les patients ont été classés selon le résultat de l’analyse nutritionnelle : bien nourri, à risque de dénutrition et dénutri. Résultats De nos 80 patients (43 ± 15 ans), 19 étaient en ENR (24%), 47 en ECM (59%) et 14 en EECM (17%). Parmi eux, 7 (9%) étaient à risque de dénutrition et les 73 autres (91%) étaient bien nourris. L’IMC de ces sujets n’est pas lié à leur niveau d’ECA (p = 0,093), au délai après l’accident (p = 0,12) ou à l’étiologie de leur état neurologique (p = 0,51). Une différence entre l’apport énergétique réellement administré à ces patients et celui qu’ils devraient théoriquement recevoir sur base des recommandations nutritionnelles (30 kcal/kg de poids de calcul) est observée. Les sujets obèses (≥ 30 kg/m²) recevaient 631 ± 328 kcal en moins/jour par rapport aux recommandations et ceux en surpoids (25-29,9 kg/m²), 415 ± 390 kcal/j en moins également. En revanche, les patients avec un IMC faible (< 18,5 kg/m²) recevaient 106 kcal ± 299 kcal/j en plus. La comparaison du niveau de spasticité en fonction de l’IMC révèle une corrélation significative (r = - 0,30, p = 0,009) et montre que les patients les moins spastiques au niveau des membres inférieurs sont plus à risque d’avoir un surpoids (IMC = 27,7 ± 7,5 kg/m²). Au contraire les plus spastiques à ce niveau sont plus à risque d’avoir un IMC plus faible (22,1 ±3,8 kg/m²). Parmi les 9 sujets avec un IMC < 18,5 kg/m², 7 présentent une spasticité sévère, et les 2 autres une spasticité modérée, au niveau des membres inférieurs. L’étude de la différence d’apport énergétique par rapport à la spasticité montre que les patients non spastiques recevaient 297 ± 318 kcal/j en moins par rapport aux recommandations, contre 222 ± 430 kcal/j pour une spasticité moyenne et 41 ± 406 kcal/j pour des niveaux de spasticité plus élevés. Conclusion Nos résultats indiquent que la majorité des patients ECA ont un état nutritionnel satisfaisant. Cet état nutritionnel ne semble pas lié au niveau de conscience, ni au délai ou à la cause de leur accident. Les patients les moins spastiques présentent des critères de surpoids malgré un apport énergétique considérablement réduit par rapport aux recommandations nutritionnelles. En revanche, un niveau élevé de spasticité est associé à un niveau de sous poids (IMC < 18,5 kg/m²) en dépit d’un apport énergétique supérieur à l’objectif préconisé par ces recommandations. Des analyses complémentaires sont en cours (calorimétrie indirecte, impédancemétrie, étude de la spasticité et imagerie métabolique) afin de mieux comprendre les mécanismes sous-jacents. [less ▲]

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See detailAssessment of mammal biodiversity and bushmeat offtake in the tropical forests of southeastern Cameroon
Lhoest, Simon ULiege; Fonteyn, Davy ULiege; Hette, Samuel et al

Poster (2018, November 27)

Tropical forests of central Africa host an important part of the world’s terrestrial biodiversity and provide numerous provisioning, regulating, and cultural ecosystem services to human populations. Major ... [more ▼]

Tropical forests of central Africa host an important part of the world’s terrestrial biodiversity and provide numerous provisioning, regulating, and cultural ecosystem services to human populations. Major threats hang over those diverse ecosystems, namely land use changes and consumption of bushmeat. Our study aimed to assess mammal diversity and bushmeat consumption in three contrasted and largely represented forest land allocation types in southeastern Cameroon: (i) a protected area, (ii) a FSC-certified logging concession, and (iii) three community forests. Mammal inventories were conducted with 44 camera traps installed for 3 months. Bushmeat consumption was quantified using both tracking of volunteer hunters over 651 kilometers and the daily monitoring of the food bowl of 55 households for 3 months. Though a great part of the mammal diversity is retained inside the logging concession, the protected area holds the richest and most abundant mammal communities, whereas community forests were found to be defaunated and structurally disturbed. The size of the hunting territories is influenced by many factors such as human population density or the presence of alternative protein sources. Although poaching controls in the protected area and, to a lesser extent, in the certified logging concession appear to play a deterrent role, evidence of hunting activities were found in all land allocation types. Bushmeat represents on average 56% of the animal protein consumed by households, the remaining part being mainly fish. Our results demonstrated the ability of the certified logging concession and the protected area in the conservation of wildlife species and the provision of bushmeat for local populations. It remains essential to maintain and develop anti-poaching patrols in those areas, strategically based on geographic data of hunting pressure. Current levels of hunting activities also confirm the need for the development of alternatives to bushmeat. [less ▲]

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See detailGestion de la reproduction des Faux bourdons par les apiculteurs de la Wilaya de Tizi-Ouzou
Yahi, Krimou; Kaidi, Rachid; Touazi, Leghel et al

Poster (2018, November 26)

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See detailCaractérisation de l'apiculture dans la Wilaya de Sétif
Touazi, Leghel; Yahi, Krimou; Moula, Nassim ULiege

Poster (2018, November 26)

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See detailElectrochemical mechanism and effect of carbon addition during hydrothermal synthesis to improve the electrochemical performance of Fe1.19(PO4)(OH)0.57(H2O)0.43 cathode material for Li-ion batteries
Mahmoud, Abdelfattah ULiege; karegeya, Claude; Sougrati, Moulay Tahar et al

Poster (2018, November 25)

Since the introduction of lithium-ion batteries (LIBs) to market in 1991, their performance has improved significantly, which has been achievable through development in materials technologies. However ... [more ▼]

Since the introduction of lithium-ion batteries (LIBs) to market in 1991, their performance has improved significantly, which has been achievable through development in materials technologies. However, further breakthroughs are still needed to ameliorate cycle-life, safety and energy density of LIBs. This requires new electrode materials and a detailed understanding of the electrochemical mechanisms during cycling. Transition metal phosphates are interesting candidates as cathode materials for LIBs [1]. In this work, we report the electrochemical performance of FPHH/C and FPHH/CNT composites where FPHH represents Fe1.19(PO4)(OH)0.57(H2O)0.43 while carbon black and carbon nanotubes (CNT) were used as precursors in the one-pot hydrothermal synthesis, respectively. We show that the addition of conducting carbon black into the solution has a strong influence on reducing the particle size and tailoring their morphology, but does not interfere with the formation of the FPHH phase. Thanks to its favorable microstructural characteristics, the FPHH-10 wt% C and FPHH-20 wt% C materials exhibited good performance [2]. The CNT also improve the performance of FPHH such as capacity retention (500 cycles at 1 C). The mechanisms of lithiation-delithiation were investigated by combining operando X-ray diffraction and 57Fe Mössbauer spectroscopy. FPHH undergoes a monophasic reaction based on Fe3+/Fe2+ redox process. However, the variations of the lattice parameters and 57Fe quadrupole splitting indicate a more complex mechanism than a random occupation of the vacant sites within FPHH. This can be related to the peculiar structure of FPHH formed by chains of face sharing (Fe0.6•0.4)O6 octahedra connected by PO4 tetrahedra and by channels for Li diffusion along [100] and [010] directions. The existence of Fe vacancies provide interconnections between the one-dimensional channels, improving lithium diffusion within FPHH. This mechanism, combined with the addition carbon black or nanotubes in the solution prior to hydrothermal treatment as a simple and effective way to reduce particle size and improve electronic conductivity, provides good cycle life and rate capability for FPHH. Acknowledgements A. Mahmoud is grateful to University of Liege and FRS-FNRS for the grants and thanks to the Walloon region for a Beware Fellowship Academia 2015-1, RESIBAT n° 1510399. Part of this work was supported by the Walloon Region under the “PE PlanMarshall2.vert” program (BATWAL – 1318146). References 1. C. Karegeya, A. Mahmoud, F. Hatert, B. Vertruyen, R. Cloots, P.E. Lippens, F. Boschini, Journal of Power Sources 388 (2018) 57-64. 2. C. Karegeya, A. Mahmoud, R. Cloots, B. Vertruyen, F. Boschini, Electrochim. Acta 250 (2017) 49-58. [less ▲]

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See detailSpray drying synthesis of Na3V2(PO4)2F3/C cathode material for Na-ion batteries: study of the effect of the carbon source on electrochemical performance
Eshraghi, Nicolas ULiege; Bodart, Jérôme ULiege; Mahmoud, Abdelfattah ULiege et al

Poster (2018, November 25)

Lithium-ion batteries have enjoyed great success and have outperformed other rechargeable battery system since 1980. However, Li-ion batteries face many challenges and limitations: safety, the low ... [more ▼]

Lithium-ion batteries have enjoyed great success and have outperformed other rechargeable battery system since 1980. However, Li-ion batteries face many challenges and limitations: safety, the low abundance of lithium in the Earth’s crust. Recently, Sodium-ion batteries attracted a lot of interest as a potential alternative to lithium-ion batteries for large-scale energy storage applications, due to the large natural abundance and lower cost of sodium. In recent years, fluorophosphates with the NASICON (Na Super-Ionic Conductor) type structure are considered among the most interesting series of cathode materials for Li/Na-ion batteries, because they exhibit rich chemistry, attractive lithium/sodium insertion properties and thus offer promising electrochemical properties [1]. Na3V2(PO4)2F3 (NVPF) attracted high attention thanks to its promising electrochemical properties. The inductive effects of both PO43- and F- allow for a high working potential combined with a high theoretical specific capacity due to the multiple oxidation states of vanadium[1-2]. One of the key drawbacks of Na3V2(PO4)2F3 electrodes is their low intrinsic electronic conductivity. NVPF and NVPF/carbon composite materials were prepared by spray-drying method using the same conditions used in our previous work [2]. Spray drying is a cost-effective and easily up-scalable route to prepare homogeneous multi-component powders, thus making it a suitable method to incorporate carbon in the composite powder. We used different carbon sources like conductive carbons (MWCNTs, Carbon Black, etc) and organic sources (PVA, Citric Acid, Ascorbic acid, etc) to prepare NVPF/carbon composite powders. the structural, electrochemical, and morphological properties of the synthesized Na3V2(PO4)2F3/C samples were systematically investigated in order to understand the influence of carbon source on structural and morphological properties and most importantly electrochemical performance of NVPF and NVPF/carbon composite cathode materials for Na-ion batteries. The chemical diffusion of Na ions was studied using results obtained by varying scan rates in cyclic voltammetry measurements. Raman spectroscopy is used to evaluate the quality in disordered carbon materials and its electronic conductivity [3] and compared the results with the results from EIS and cycling performance of different samples. Acknowledgments The authors are grateful to University of Liege and FRS-FNRS for grants. Part of this work was supported by the Walloon Region under the “PE PlanMarshall2.vert” program (BATWAL – 1318146). A. Mahmoud thanks to the Walloon region for a Beware Fellowship Academia 2015-1, RESIBAT n° 1510399. References: [1] R. A. Shakoor, D-H. Seo, H. Kim, Y-U. Park, J. Kim, S-W. Kim, H. Gwon, S. Leec and K. Kang, Mater. Chem. 22 (2012) 20535–20541. [2] N. Eshraghi, S. Caes, A. Mahmoud, R. Cloots, B. Vertruyen, F. Boschin, Electrochimica Acta, 228, (2017), 319-324. [3] A. Mahmoud, S. Caes, M. Brisbois, R. P. Hermann, L. Berardo, A. Schrijnemakers, C. Malherbe, G. Eppe, R. Cloots, B. Vertruyen, F. Boschin J Solid State Electrochem. 22 (2018) 103-112. [less ▲]

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See detailRéseaux de collaboration et valorisation des ressources locales en bois dans le secteur de la construction : évaluation du potentiel de développement de la filière bois wallonne par les proximités
Muytjens, Lionel ULiege

Poster (2018, November 20)

Dans un contexte de redéveloppement des circuits courts, plusieurs initiatives de valorisation des ressources locales en bois dans le secteur de la construction ont été lancées en Wallonie. Par ... [more ▼]

Dans un contexte de redéveloppement des circuits courts, plusieurs initiatives de valorisation des ressources locales en bois dans le secteur de la construction ont été lancées en Wallonie. Par l’application d’une grille de lecture dérivée de l’école des proximités, l'étude présentée au travers de ce poster cherche à identifier le potentiel de développement de ces circuits courts lorsque la filière met en place des réseaux de collaborations. Par la réalisation des seize entretiens semi-directifs et d’une enquête auprès de scieurs, grossistes en bois, constructeurs bois et architectes, des forces en termes de proximité géographique (partage d’un territoire) et de proximité de similitude (intentionnalités productives partagées) ont été relevées. A l’inverse, bien que la filière soit représentée par de nombreux acteurs et que des collaborations non formelles existent, la structure éclatée de la filière est pointée du doigt et la proximité « relationnelle » et « de média » sont jugées insuffisantes. [less ▲]

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See detailEffets d'un réentrainement attentionnel chez des étudiants dysphoriques
Vandries, Mandy; Blairy, Sylvie ULiege; Krings, Audrey ULiege

Poster (2018, November 17)

Les biais attentionnels envers l’information congruente à l’humeur et les ruminations mentales sont deux processus psychologiques impliqués dans le développement et la maintien de la dépression (Vazquez ... [more ▼]

Les biais attentionnels envers l’information congruente à l’humeur et les ruminations mentales sont deux processus psychologiques impliqués dans le développement et la maintien de la dépression (Vazquez & al., 2016 ; Bayens & al., 2012). Ces deux mécanismes seraient liés, puisqu’ils seraient sous-tendus par une diminution des ressources cognitives qui perturberait le désengagement de l’attention de stimuli en lien avec les préoccupations (Koster, De Lissnyder, Derakshan & De Raedt, 2011). Afin d’améliorer l’humeur, les chercheurs se sont penchés sur la modification des biais attentionnels ou réentrainement attentionnel, à l’aide de tâches informatisées (Beevers & al., 2015 ; Wells & Beevers, 2010). Le but de ces dernières est de diminuer l’allocation de l’attention, des individus déprimés, envers les stimuli tristes. De plus, étant donné l’existence d’un lien entre le biais attentionnel et les ruminations mentales, la modification du biais négatif pourrait également avoir des effets sur le processus ruminatif. Une récente étude suggère que l’impact du biais attentionnel sur l’humeur dépressive serait médié par les ruminations mentales (Yang & al., 2015). Malheureusement, il n’existe actuellement que peu d’études ayant investiguées l’impact du réentrainement attentionnel sur les ruminations mentales. L’objectif de notre étude est donc d’évaluer l’effet d’un réentrainement attentionnel, chez des sujets présentant une symptomatologie dépressive moyenne à modérée, sur l’humeur dépressive, le biais attentionnel négatif ainsi que sur les ruminations mentales. Le second objectif est de tester la faisabilité et la mise en place de ce type de protocole chez des étudiants. Nous nous attendons à ce que les séances de réentrainement attentionnel aient un impact positif sur l’humeur, le biais attentionnel ainsi que sur les ruminations mentales. L’échantillon était composé de 6 étudiants, âgés de 18 à 23 ans, dont le score à la BDI-II est égal ou supérieur à 12 (Beck, 1997). Ces derniers ont été vus à cinq reprises. Trois temps d’évaluations ont été proposés : avant réentrainement (séance 1 - t0), après réentrainement (séance 4 – t1) et un mois après le dernier réentrainement (séance 2 – t2). Les évaluations étaient composées de questionnaires auto-complétés évaluant l’humeur dépressive (BDI-II) et les ruminations mentales (RRS), ainsi que d’une tâche informatisée de discrimination de cible évaluant les biais attentionnels. Quatre séances de réentrainement ont également été proposées en laboratoire (séances 1, 2, 3 – t0 et 4 – t1). Durant ces dernières, quatre participants ont effectué une tâche informatisée de discrimination de cible, visant la modification des biais attentionnels, tandis que deux participants ont effectué une tâche contrôle. Les participants ont également réalisé cette tâche à domicile, trois fois, entre les séances. Des analyses de cas ont été réalisées sur ces données en raison d’une petite taille d’échantillon La tâche de réentrainement attentionnel n’a pas été en mesure d’obtenir les effets auxquels nous nous attendions. L’absence de résultats peut-être attribuée à certaines limites inhérentes à notre étude. Tout d’abord, notre échantillon n’était composé que de six participants. Ensuite, seul un participant présentait initialement un biais négatif, alors que cette condition est essentielle pour obtenir des résultats concluants (Nishiguvhi & al., 2015 ; Wells & Beevers, 2010). Enfin, des évènements externes, tels que la période d’examens des étudiants, sont susceptibles d’avoir influencés négativement l’humeur de nos participants. [less ▲]

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See detailEtude des liens entre l’activation comportementale, l’évitement comportemental et les symptômes de la dépression en fonction du genre : Une étude de réplication.
Krings, Audrey ULiege; Wagener, Aurélie ULiege; Blairy, Sylvie ULiege

Poster (2018, November 17)

INTRODUCTION: La dépression est un trouble très prévalent dont les conséquences sociétales en termes économiques, sociales et personnelles sont importantes (World Health Organization, 2017). Cette ... [more ▼]

INTRODUCTION: La dépression est un trouble très prévalent dont les conséquences sociétales en termes économiques, sociales et personnelles sont importantes (World Health Organization, 2017). Cette pathologie est associée à des différences de genre (Parker & Brotchie, 2010). Wagener et al. (2016) ont notamment montré des différences de genre dans les profils de symptômes rapportés (e.g., des scores plus élevés de tristesse, d'auto-critique chez les femmes, des scores plus élevés d'échecs passés et de perte de plaisir chez les hommes). Dans leur étude, les auteurs se sont également intéressés aux liens entre d’une part l’activation comportementale et l’évitement comportemental et d’autre part la présence d’une symptomatologie dépressive et ce, en tenant compte du genre. Leurs résultats suggèrent que l'évitement comportemental prédit positivement presque tous les symptômes dépressifs chez les femmes et les hommes tandis que l'activation comportementale prédit négativement presque tous les symptômes des deux genres. Notre objectif a été de répliquer les résultats de cette étude. MÉTHODE : 260 sujets tout-venants (165 femmes, 95 hommes) ont complété une échelle évaluant la symptomatologie dépressive (BDI-II) ainsi qu’une échelle évaluant l’activation comportementale et l’évitement comportemental (BADS-SF). RÉSULTATS: Comme dans l’étude initiale, les femmes rapportent des scores plus élevés de tristesse, d’indécision, d’augmentation de l’appétit et de perte d’intérêt pour le sexe. Cependant, nos résultats ne suggèrent pas des scores plus élevés pour les échecs passés et la perte de plaisir chez les hommes. Dans notre échantillon, l'évitement comportemental prédit positivement une majorité de symptômes dépressifs chez les femmes et les hommes, tandis que l'activation comportementale prédit négativement un ensemble de symptômes, mais pas une majorité. CONCLUSIONS: Les résultats seront discutés par rapport à l’étude initiale et aux implications cliniques actuelles: (1) pour souligner la pertinence de la combinaison d'outils d'évaluation spécifiques au genre; (2) souligner le besoin d'une intervention psychologique sur mesure. [less ▲]

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See detailComparison of three automated strip analyzers to Cobas 800 for the analysis of glucose, proteins, albumin and creatinine
Castiglione, Vincent ULiege; GADISSEUR, Romy ULiege; Bernard, Maxime ULiege et al

Poster (2018, November 16)

Urine glucose, proteins, albumin and creatinine are measured for the screening of diabetes and renal diseases. The automated strip analyzers are used for quick screening of large populations. The goal of ... [more ▼]

Urine glucose, proteins, albumin and creatinine are measured for the screening of diabetes and renal diseases. The automated strip analyzers are used for quick screening of large populations. The goal of this study was to compare a more accurate method, the Cobas 8000 (Roche, Bale, Switzerland) to three automated analyzers: the Clinitek Novus (Siemens, Munich, Germany), the UC-3500 (Sysmex, Kobe, Japan) and the AutionMax (Menarini, Florence, Italy). A total of 284 urine samples were prospectively collected for the comparison. The samples were analyzed on the three analyzers within 2 hours. Before the analysis of samples by each method, an aliquot was frozen at -80°C. All samples were then defrost and analyzed in one batch with the Cobas 8000 (Roche, Bale, Switzerland) within the month. The diagnostic accuracy was determined thanks to the results of the Cobas 8000. However, the creatinine and albumin cannot be assessed with the AutionMax. [less ▲]

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See detailUrine sediment analysis: comparison of three automated analyzers to manual microscopy
Castiglione, Vincent ULiege; GADISSEUR, Romy ULiege; Bernard, Maxime ULiege et al

Poster (2018, November 16)

Urine microscopic analysis is an old method that reveals information about kidney health. Several automated analyzers, that are less time-consuming, are currently available, but manual microscopy is still ... [more ▼]

Urine microscopic analysis is an old method that reveals information about kidney health. Several automated analyzers, that are less time-consuming, are currently available, but manual microscopy is still the gold-standard method. The goal of this study was to validate and compare three automated analyzers to manual microscopy: the Atellica UAS800 (Siemens, Munich, Germany), the UF-4000 (Sysmex, Kobe, Japan) and the SediMax (Menarini, Florence, Italy). We first validated each analyzer. A total of 359 samples were analyzed with the three analyzers and with a manual microscope within 2 hours. Two trained reviewers used a microscope with bright field, contrast phase and polarized light to identify urine elements. The diagnostic accuracy was determined thanks to microscopy results. [less ▲]

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See detailDiagnostic accuracy of three automated urine analyzers compared to urine culture
Castiglione, Vincent ULiege; GADISSEUR, Romy ULiege; Bernard, Maxime ULiege et al

Poster (2018, November 16)

Urine culture is an important diagnosis method of urinary tract infection. However, it is time-consuming and results aren’t available quickly. Automated urine analyzers have been developed to screen urine ... [more ▼]

Urine culture is an important diagnosis method of urinary tract infection. However, it is time-consuming and results aren’t available quickly. Automated urine analyzers have been developed to screen urine samples more rapidly. The goal of this study was to compare three automated analyzers to urine culture: the Atellica UAS 800 (Siemens, Munich, Germany), the UF-4000 (Sysmex, Kobe, Japan) and the SediMAX (Menarini, Florence, Italy). We first validated each analyzer. We analyzed then 318 samples with the three analyzers within 2 hours after sample reception. An urine aliquot was collected before sediment analysis for bacteria culture. Ten microliters of un-centrifuged urine was inoculated on blood agar and CLED agar plates, then they were incubated aerobically at 36°C for 24 h. Bacteria count of each analyzer was compared to urine culture to determine diagnostic accuracy. The result was considered positive when the bacteria growth reached 104 CFU/ml. We also used the results of leukocytes and nitrites results from the strip measurement to improve the accuracy. The abilities of the UF-4000 to distinguish Gram positive (GP) from Gram negative (GN) bacteria, and of the UAS 800 to identify rod and cocci, were determined. [less ▲]

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See detailRaman chemical imaging, a new tool in kidney stone structure analysis: Case-study and comparison to Fourier Transform Infrared spectroscopy
Castiglione, Vincent ULiege; Sacre, Pierre-Yves ULiege; Cavalier, Etienne ULiege et al

Poster (2018, November 16)

The kidney stone’s structure might provide clinical information in addition to the stone composition. The Raman chemical imaging is a technology used for the production of two- dimension maps of the ... [more ▼]

The kidney stone’s structure might provide clinical information in addition to the stone composition. The Raman chemical imaging is a technology used for the production of two- dimension maps of the constituents’ distribution in samples. We aimed at determining the use of Raman chemical imaging in urinary stone analysis. Fourteen calculi were analyzed by Raman chemical imaging using a confocal Raman micro- spectrophotometer. They were selected according to their heterogeneous composition and morphology. Raman chemical imaging was performed on the whole section of stones. Once acquired, the data were baseline corrected and analyzed by MCR-ALS. Results were then compared to the spectra obtained by Fourier Transform Infrared spectroscopy. [less ▲]

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See detailDo Older Adults' Growth Mindsets Predict Their Willingness to Engage in Preventative Health Behaviors?
Marquet, Manon ULiege; Chasteen, Alison L; Plaks, Jason E et al

Poster (2018, November 15)

Promoting health behaviors among older adults has become increasingly important given the accumulating health problems that can accompany older age. The present study examined the linkages between ... [more ▼]

Promoting health behaviors among older adults has become increasingly important given the accumulating health problems that can accompany older age. The present study examined the linkages between implicit theories regarding the modifiability of abilities, health behaviors, and subjective age among older adults. A total of 147 older adults (Mean age = 68.62, SD = 5.40) completed, among other measures, questions assessing their implicit theories of ability and their subjective age. They also reported their perceptions of the benefits of different health behaviors (i.e., healthy sleep and diet habits, exercising, and seeking help for hearing or vision problems) for slowing the effects of aging as well as their intentions to engage in those behaviors. As hypothesized, we found that the more older people believed that abilities are changeable, the more they perceived benefits of health behaviors, which in turn increased their intentions. Also, the greater their intentions, the younger the subjective age they reported. The finding that perceived benefits mediated the relationship between implicit theories and intentions toward health behaviors may have important implications for designing interventions to promote and maintain an active and healthy lifestyle in later life. Interventions that focus on modifying fixed mindsets regarding general abilities could indirectly yield positive consequences on intentions to engage in health behaviors by leading older people to see those behaviors as useful for slowing the effects of aging. [less ▲]

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See detailEstetrol, a newly designated orphan drug, for attenuation of neonatal Hypoxic-Ischemic Encephalopathy (HIE)
Tskitishvili, Ekaterine ULiege; Pequeux, Christel ULiege; VIELLEVOYE, Renaud ULiege et al

Poster (2018, November 13)

Estetrol, a newly designated orphan drug, for attenuation of neonatal Hypoxic-Ischemic Encephalopathy (HIE) Ekaterine Tskitishvili1*, Christel Pequeux1, Renaud Viellevoye2, Michelle Nisolle3, Agnes Noël1 ... [more ▼]

Estetrol, a newly designated orphan drug, for attenuation of neonatal Hypoxic-Ischemic Encephalopathy (HIE) Ekaterine Tskitishvili1*, Christel Pequeux1, Renaud Viellevoye2, Michelle Nisolle3, Agnes Noël1 and Jean-Michel Foidart1 1Laboratory of Development Biology and Tumor, University of Liege, Liege, Belgium; 2Department of Pediatrics, University of Liege, Liege, Belgium; 3Department of Ob/Gyn, University of Liege, Liege, Belgium Estetrol (E4) is a fetal estrogen synthesized only during human pregnancy. We aimed to study its role in attenuation of neonatal HIE. In vitro we defined antioxidative and cell viability effects of E4 on primary hippocampal cell cultures in oxidative stress condition by using lactate dehydrogenase (LDH) activity and cell survival (MTS) assays. To study the neuroprotective and therapeutic effects of E4 in vivo neonatal HIE model of 7-day-old newborn rat pups was used. Brains were studied at the level of the hippocampus and cortex. Intact cell counting and expressions of markers for gray and white matter (MAP-2 and MBP), neurogenesis (DCX) and angiogenesis (VEGF) were evaluated by histo- and immunohistochemistry. The serum levels of brain damage markers (S100B and GFAP) were measured by ELISA. Our results demonstrate that E4 has significant antioxidative and cell survival properties along with neuroprotective and therapeutic effects. It decreases the early gray and white matter loss and promotes neuro- and angiogenesis in vivo. Combined use of E4 with other steroids does not have priority over the single use of E4. We also defined that E4's antioxidative actions mostly depend on ERα and ERβ, whereas neurogenesis and possibly promyelinating activities might be realized through ERβ. Treatment by E4 has no effects on body weight, brain weight or body temperature. E4 might become an important safe and physiological substance to treat neonatal HIE. Based on our data EMA granted orphan drug designation to E4. References 1.Tskitishvili E, Nisolle M, Munaut C, Pequeux C, Gerard C, Noel A, Foidart JM.Estetrol attenuates Neonatal Hypoxic-Ischemic brain injury. Exp Neurol 2014; 261:298-307. 2. Tskitishvili E , Pequeux C, Munaut C, Viellevoye R, Nisolle M, Noel A, Foidart JM. Use of Estetrol with other Steroids for Attenuation of Neonatal Hypoxic-Ischemic brain injury: to combine or not to combine? Oncotarget 2016; 7(23):33722-43. 3. Tskitishvili E,Viellevoye R, Gerard C, Pequeux C, Munaut C, Nisolle M, Noel A, Foidart JM. Neonatal Hypoxic-Ischemic Encephalopathy: a new view of an old problem. Références en Gynécologie Obstetrique. 2016 17;1-4 4. Tskitishvili E, Pequeux C, Munaut C, Viellevoye R, Nisolle M, Noël A, Foidart JM. Estrogen receptors and estetrol-dependent neuroprotective actions: a pilot study. J Endocrinol. 2017; 232(1):85-95. 5.Foidart JM, Tskitishvili E. International patent application. Estrogenic components for use in the treatment of neurological disorders. [less ▲]

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See detailOperando Mössbauer study of Fe4+/Fe3+ redox couple in NaFeO2
Sougrati, Moulay-Tahar; Stievano, Lorenzo; Darwiche, Ali et al

Poster (2018, November 12)

Among the potential positive electrode materials for Na-ion batteries, iron-based compounds have been regarded as promising candidates for the reversible (de)intercalation of Na on the basis of their high ... [more ▼]

Among the potential positive electrode materials for Na-ion batteries, iron-based compounds have been regarded as promising candidates for the reversible (de)intercalation of Na on the basis of their high abundance in the Earth’s crust and their low environmental impact. The model oxide O3-type NaFeO2, synthesized via the simple reaction of iron oxide and Na2CO3 at 600°C, has been identified as the most interesting one from the viewpoint of both gravimetric and volumetric energy density.[1–3] Na/NaFeO2 cells cycle through a relatively flat potential plateau between 3.3 and 3.4 V vs. Na+/Na, commonly linked with the Fe4+/Fe3+ redox couple. However, if cycling is extended above 3.5 V, other irreversible reaction plateaus appear, leading to the material degradation. 57Fe Mössbauer spectroscopy is thus a method of choice for the study of both (1) the cycling mechanism and (2) the irreversible reactions occurring above 3.5 V. In this work, operando 57Fe Mössbauer analysis was carried out during the electrochemical cycling of NaFeO2 vs. Na metal using a specifically designed in situ cell,[4] and analysed using an alternative and innovating data analysis approach based on chemometric tools such as Principal Component Analysis (PCA) and multivariate curve resolution (MCR).[5,6] This approach, which allows the unbiased extraction of all possible information from the operando data, enabled the stepwise reconstruction of the “real” spectral components occurring during the cycling of NaFeO2. In this way, a clear description of the electrochemically active iron species could be obtained, allowing a clearer comprehension of the cycling mechanisms of this material vs. sodium. References [1] J. Zhao, L. Zhao, N. Dimov, O. Shigeto, T. Nishida, J. Electrochem. Soc. 160 (2013) A3077. [2] H. Yoshida, N. Yabuuchi, S. Komaba, in:, ECS Meet. Abstr. MA2012-02, ECS, Honolulu, 2011, p. 1850. [3] P. Barpanda, Chem. Mater. 28 (2016) 1006. [4] J.-B. Leriche, S. Hamelet, J. Shu, M. Morcrette, C. Masquelier, G. Ouvrard, M. Zerrouki, P. Soudan, S. Belin, E. Elkaïm, F. Baudelet, J. Electrochem. Soc. 157 (2010) A606. [5] R. Tauler, Chemom. Intell. Lab. 30 (1995) 133. [6] A. Voronov, A. Urakawa, W. van Beek, N.E. Tsakoumis, H. Emerich, M. Rønning, Anal. Chim. Acta 840 (2014) 20. [less ▲]

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See detailApplication d'un bridge dentaire pour traiter de larges fistules orales chez 2 chevaux
Storms, Nazaré ULiege; de la Rebière de Pouyade, Geoffroy ULiege; Grulke, Sigrid ULiege et al

Poster (2018, November 08)

Introduction : Chez les chevaux, des fistules oro-sinusales et oro-cutanées peuvent survenir après expulsion dentaire. Souvent, celles-ci se résolvent après débridement de la fistule et application d’un ... [more ▼]

Introduction : Chez les chevaux, des fistules oro-sinusales et oro-cutanées peuvent survenir après expulsion dentaire. Souvent, celles-ci se résolvent après débridement de la fistule et application d’un ‘bouchon’ temporaire au niveau de l’alvéole de la dent expulsée. Lorsque la fistule est très large, la stabilisation de ce bouchon est parfois impossible et des techniques de comblement de la fistule par transposition musculaire (levator nasolabialis ou levator labii superioris) peuvent aboutir à une étanchéité incomplète. Nous décrivons ici l’application d’un bridge dentaire pour traiter de larges fistules oro-sinusale ou oro-cutanée chroniques, ainsi que nos résultats chez 2 chevaux. Anamnèse – examen clinique – démarche diagnostique : Le premier cas est un hongre Westphalien de 12 ans, présenté pour jetage nasal purulent survenu 4 ans après l’expulsion de la dent 209. Le deuxième cas est un hongre Oldenburg de 5 ans, présenté pour une fistule purulente rostrale à la crête faciale, 7 semaines post expulsion de la dent 208. Des fistules oro-sinusale (cas n°1) et oro-cutanée (cas n°2) ont été mises en évidence par buccoscopie et radiographie. Traitement : Sous anesthésie générale, après débridement de la fistule, un fil de cerclage formant un ‘8’ en prenant appui au niveau des espaces interdentaires rostral et caudal à la fistule a été appliqué au moyen d’une approche orale et transbuccale. Les fils de cerclage se croisant au niveau de la fistule ont ensuite été englobés dans du polyméthylmétacrylate (PMMA) de manière à étanchéifier la cavité buccale tout en évitant le comblement en profondeur de la fistule. Les 2 chevaux ont très bien toléré leur bridge, et leurs symptômes ont rapidement disparu après l’intervention. Le bridge était toujours en place après 2 ans chez le cas 1. Chez le cas 2, le bridge a été retiré après 1,5 an suite au comblement total de la fistule. Discussion : Cette technique présente les avantages de ne pas nécessiter de matériel spécialisé ni coûteux, d’être peu invasive et très bien tolérée par les chevaux. Néanmoins, ce bridge nécessite un ancrage au niveau des espaces interdentaires rostral et caudal à la fistule. Dès lors, cette technique est particulièrement indiquée pour les fistules des alvéoles ‘08’ ou ‘09’ mais moins pour celles des autres dents. Conclusion : L’application d’un bridge composé de PMMA et de fil de cerclage est une technique peu invasive et efficace pour traiter certaines larges fistules oro-sinusales et oro-cutanées. [less ▲]

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See detailScientific literature uses in Geography: indexing and “overlap” in four bibliographic tools
Stirbu, Simona ULiege; Greco, Ninfa ULiege

Poster (2018, November 06)

This research aims to evaluate the interest for geographers to use Google Scholar(GS) over the commercial databases Web of Science (WoS), Scopus (multidisciplinary databases), and GeoRef (specialized in ... [more ▼]

This research aims to evaluate the interest for geographers to use Google Scholar(GS) over the commercial databases Web of Science (WoS), Scopus (multidisciplinary databases), and GeoRef (specialized in geosciences). To achieve our main objective, we performed searches in order to verify to which extent researchers' citations are covered by the search engine and the three commercial bibliographic databases mentioned. Our sample consists of the citations of three dissertations in Geography presented in the Uliège (Belgium) Department of Geography during the 2014-2015 academic year, respectively in Climatology, Tourism and Geomatics. In order to have an overview of the results’ “overlap” for the bibliographic tools, and their "unique" contribution, Venn diagrams were constructed for each thesis. The Venn diagrams indicate that GS finds almost all bibliographic references and returns the greatest number of "unique" results. The “overlap” rates between the commercial databases is very high and GeoRef stands out with very low results. GS is an important and rich complementary tool, with a more varied panel of publishers, languages and countries of publication. [less ▲]

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See detailDoes in vitro protocol predict the nutritional value of thermally treated cereals?
Huart, François ULiege; Bera, François ULiege; Blecker, Christophe ULiege et al

Poster (2018, November 06)

Several in vitro protocols were proposed to rapidly evaluate the nutritional value of cereal and food ingredients. These In vitro protocols are based on restricted parameters and may involve results ... [more ▼]

Several in vitro protocols were proposed to rapidly evaluate the nutritional value of cereal and food ingredients. These In vitro protocols are based on restricted parameters and may involve results differing to the reality once assessed in vivo. Moreover, information about some in vitro parameters is sometimes insufficiently described. In the present study, a three steps in vitro digestion simulation developed by Tervila-Wilo et al. (1996) to mimic digestion in poultry digestive tract was assessed and compared with in vivo digestibility of corn grain harvest at two moisture contents and dried at three temperatures. In vitro digestion simulation showed that increasing drying temperature led to an increase in in vitro digestibility of dry matter (IVDMD) while in vivo digestibility of dry matter (DM) measured on force fed broilers chickens decreased in the same conditions. To improve this in vitro digestion model, the effect of amylase activity of pancreatin, substrate concentration, corn flour particles reduction and agitation were investigated. Results showed that increasing amylase activity of pancreatin and decreasing substrate concentration improved DM digestibility through starch digestibility while corn flour particles reduction had little effect on its final DM digestibility. Rotational agitation greatly improved starch digestibility and therefore DM digestibility, even at low speed. This increase in DM digestibility reached 20% and was attributed to the better contact between substrate and enzymes and a reduction in solution viscosity under constant agitation. A good adjustment of these parameters would improve the ability of in vitro digestion simulation to accurately predict nutritional value of thermally treated cereals. They have to be taken into account on the implementation of in vitro digestion simulation aiming to predict in vivo performances of consumers. [less ▲]

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See detailTowards a stable isotope database for deep-sea foundation species
Michel, Loïc ULiege; Dubois, Stanislas; Hayden, Brian et al

Poster (2018, November)

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See detailHow Much Do We Gain From Greater Personalisation?
Uyttendaele, Vincent ULiege; Knopp, Jennifer L.; Shaw, Geoffrey M. et al

Poster (2018, November)

Objective: STAR (Stochastic TARgeted) is risk-based glycaemic control (GC) using prediction of future insulin sensitivity (SI) variability to safely dose insulin and nutrition, where SI variability is the ... [more ▼]

Objective: STAR (Stochastic TARgeted) is risk-based glycaemic control (GC) using prediction of future insulin sensitivity (SI) variability to safely dose insulin and nutrition, where SI variability is the key driver in GC difficulty and hypoglycaemia. Currently, STAR uses a 2D stochastic model where current identified patient-specific SI is used to predict future SI variability in a cohort-specific sense. This study assesses the impact on GC performance of a new, more patient-specific 3D stochastic model, using previous and current SI values to predict metabolic variability. Method: Bi-variate and tri-variate Gaussian kernel density methods are used to estimate conditional probability estimation of future SI knowing current SI (2D model) and also previous SI (3D model). Models are built randomly using 411 (70%) of retrospective GC episodes. They are tested using clinically validated virtual trials on the 176 (30%) remaining patients, repeating 3 times (N=528 episodes). Safety, performance, and workload are compared. Results: Out of the total 528 simulated episodes, workload was similar (11.6 measures/day). Performance was similar (90% in 80-145mg/dL band), but tighter for the 3D model (78% vs 74% in 80-125mg/dL band). Median BG level was lower for the 3D model (108 [99, 120] vs. 113 [103, 124]mg/dL), with higher insulin (3.0 [1.5, 5.0] vs 2.5 [1.5, 4.0] U/h) and nutrition (99 [66, 100] vs 92 [70, 100] % goal feed). Safety was very slightly better for the 2D model (2% vs 3% BG<72mg/dL; 1% vs 1.4% BG<40mg/dL). Conclusions: The new, more personalised 3D stochastic model provides moderately improved performance and similar safety and workload. Overall, results suggest greater personalization in predicting variability can improve STAR GC performance and justify implementation to see if it improves outcomes. [less ▲]

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See detailAqueous N-Doped TiO2 Catalysts for Visible Light Photocatalytic Applications
Mahy, Julien ULiege; Cerfontaine, Vincent; Poelman, Dirk et al

Poster (2018, November)

In this work, TiO2 prepared with an aqueous sol-gel synthesis by peptization process is doped with nitrogen precursor to extend its activity towards the visible region. Three N-precursors are used: urea ... [more ▼]

In this work, TiO2 prepared with an aqueous sol-gel synthesis by peptization process is doped with nitrogen precursor to extend its activity towards the visible region. Three N-precursors are used: urea, ethylenediamine and triethylamine. Different molar N/Ti ratios are tested and the synthesis is adapted for each dopant. For urea- and trimethylamine-doped samples, anatase-brookite TiO2 nanoparticles of 6–8 nm are formed, with a specific surface area between 200 and 275 m2 g−1. In ethylenediamine-doped samples, the formation of rutile phase is observed, and TiO2 nanoparticles of 6–8 nm with a specific surface area between 185 and 240 m2 g−1 are obtained. X-ray photoelectron spectroscopy (XPS) and diffuse reflectance measurements show the incorporation of nitrogen in TiO2 materials through Ti–O–N bonds allowing light absorption in the visible region. Photocatalytic tests on the remediation of water polluted with p-nitrophenol show a marked improvement for all doped catalysts under visible light. The optimum doping, taking into account cost, activity and ease of synthesis, is up-scaled to a volume of 5 L and compared to commercial Degussa P25 material. This up-scaled sample shows similar properties compared to the lab-scale sample, i.e., a photoactivity 4 times higher than commercial P25. [less ▲]

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See detailInsulin-Only STAR: Liège Clinical Trial Interim Results on Safety and Efficacy
Uyttendaele, Vincent ULiege; Knopp, Jennifer L.; PIROTTE, Marc ULiege et al

Poster (2018, November)

Objective: Stress-induced hyperglycaemia and insulin resistance is common in critically ill patients and associated with worsened outcomes. STAR (Stochastic TARgeted) glycaemic control (GC) has proven ... [more ▼]

Objective: Stress-induced hyperglycaemia and insulin resistance is common in critically ill patients and associated with worsened outcomes. STAR (Stochastic TARgeted) glycaemic control (GC) has proven effective over different units and clinical practices. However, this risk-based dosing approach uses both insulin and nutrition to control glycemia, where virtually all others use insulin only. This study uses STAR with insulin only and nutrition set clinically in the University Hospital of Liège, Belgium, to assess safety and efficacy in this use. Method: STAR-Liège is an insulin-only version of STAR targeting 80-145mg/dL. Patient are included if two successive BG measurements are >145mg/dL. Insulin is administered through IV catheter continuously and nutrition clinically set. GC was stopped after 72h or if BG was stable at insulin rate ≤2U/h. Safety is assessed by the %BG in severe (<40mg/dL), mild (<72mg/dL) hypoglycaemia, and >180mg/dL. Performance is evaluated by the %BG within target band and median BG. Clinical data from the first 11 patients is analysed, totalling 645 hours of control. Ethics approval was granted by the University Hospital of Liège Ethics Committee. Results: The insulin-only STAR-Liège protocol showed high performance, with median [IQR] BG of 122 [106, 147] mg/dL and 78% BG in target band. Mild hypoglycaemia occurred 1.6% of time, but there was no incidence of severe hypoglycaemia. Additionally, only 9.8% BG>180mg/dL, and administered insulin and nutrition was 4.0 [1.8, 4.6] U/h and 8.1 [4.9, 9.2] g/h. Conclusions: Insulin-only GC with the STAR-Liège protocol provided equally high control safety and quality for all patients. These results are encouraging, comparable to previous studies, and supporting STAR risk-based dosing approach as a robust solution across different ICU settings and usages, and support continuation of the clinical trial. [less ▲]

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See detailDeciphering the response of subventricular zone-nested glioblastoma cells after surgery
LOMBARD, Arnaud ULiege; Dedobbeleer, Matthias ULiege; DEWANDRE, Quentin ULiege et al

Poster (2018, November)

INTRODUCTION: Glioblastoma (GBM) is the most frequent primary malignant brain tumor in adults, with really poor prognosis, subsequent to systematic recurrences, which occur in 80% of cases in the ... [more ▼]

INTRODUCTION: Glioblastoma (GBM) is the most frequent primary malignant brain tumor in adults, with really poor prognosis, subsequent to systematic recurrences, which occur in 80% of cases in the resection margin of initial tumor. We previously demonstrated that, after experimental striatal xenotransplantation, GBM cells, and particularly GBM-initiating cells (GIC), are able to escape the tumor mass and specifically colonize the sub-ventricular zone (SVZ), a well-known neurogenic zone in adult brains. We also demonstrated that this specific oriented migration is driven by a CXCL12-CXCR4 signalization. In this study, we address the potential implication of SVZ-nested tumor cells in local GBM relapses. MATERIALS AND METHODS: We engrafted in the right striatum of nude mice GBM cells (GB138) from a human primary culture, which are previously transfected with a lentiviral construction in order to express the RFP spontaneously, while they conditionally express eGFP, only in presence of Cre-recombinase. As the GB138 cells reach the SVZ, we injected in the lateral ventricle an Adeno-Associated Viral vector expressing Cre-recombinase, which is able to infect nearby GB138 cells. We finally compared 3 mice that were not operated (control group) with 3 mice that underwent tumor resection (surgery group) and quantify green spots in the tumor mass (TM) and/or resection cavity (RC) every 20 microns thanks to Clarity Lightsheet microscope. RESULTS: We found that the median of green spots for the 3 mice of the control group was respectively 1, 0 and 0 in TM, while the median for the surgery group was 7, 8 and 47 in RC. The Standard Deviation (SD) for the control group was respectively 1.1, 0.4 and 0.6, while SD for the surgery group was respectively 1.5, 1.7 and 16. CONCLUSION: SVZ-nested GBM cells seem to be recruited for tumor relapse after surgery. [less ▲]

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See detailOptimization of calcium phosphate ceramic
Tilkin, Rémi ULiege; Regibeau, Nicolas ULiege; Grandfils, Christian ULiege et al

Poster (2018, October 29)

During the past few years, tissue engineering has become one of the most promising techniques to maintain, improve, or reconstruct human tissue, even complete human organs. This solution is frequently ... [more ▼]

During the past few years, tissue engineering has become one of the most promising techniques to maintain, improve, or reconstruct human tissue, even complete human organs. This solution is frequently based on the realization of temporary porous matrices, also called "scaffolds". These materials are highly porous matrices designed to structure the development of cells, but also to guarantee the function of the implant during the regeneration process. Several materials have been proposed for the conception of scaffolds, including calcium phosphate ceramics. Among these materials, the bioceramic class is composed of hydroxyapatite (HA), Ca5(PO4)3(OH), and β-tricalcium phosphate (TCP), β-Ca3(PO4)2. These two products are frequently used, because of their chemical and structural similarity to human bones. These similarities explain good scores observed in vitro and in vivo in terms of biocompatibility and cell colonization. [less ▲]

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See detailProduction of pure and functional Bone Morphognetic Protein-2
Robert, Charly ULiege; Matagne, André ULiege; Filée, Patrice et al

Poster (2018, October 27)

Bone Morphognetic Protein-2 (BMP-2), which belongs to the transforming growth factor β (TGF-β) superfamily, plays an important role during bone regeneration and repair, and also during various stages of ... [more ▼]

Bone Morphognetic Protein-2 (BMP-2), which belongs to the transforming growth factor β (TGF-β) superfamily, plays an important role during bone regeneration and repair, and also during various stages of embryonic development. Noggin is a BMP-specific antagonist implicated in the regulation of BMP signaling pathways. Both BMP-2 and Noggin are dimeric molecules with each subunit containing several intramolecular disulfide bonds. This complex disulfide bonds network combined with the presence of large hydrophobic patches on the surface of these proteins cause their low solubility in aqueous solutions. As a result, BMP-2 and Noggin are commonly produced as inclusion bodies in Escherichia coli. The recovery of soluble and active molecules through in vitro refolding is difficult and the overall yield is low. Here we propose a new and simple method to produce biologically active BMP-2 and Noggin. Refolding of BMP-2 and Noggin was achieved in a one-step dilution and hydrophobic or ion exchange chromatography were used to purify the refolded proteins. The best conditions yielded significant quantities of dimeric BMP-2 and Noggin, with purity above 95%. Both BMP-2 and Noggin were characterized by optical spectroscopies and its biological activity was tested by measuring alkaline phosphatase activity in ATDC5 cells. These experiments indicated that our BMP-2 and Noggin display structural and functional properties similar to their commercial counterparts. [less ▲]

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See detailEffectiveness and cost-benefit study to encourage herd owners in sharing costs for vaccination programme against bluetongue serotype-8 in Belgium
Cargnel, Mickaël ULiege; Van der Stede, Yves; Haegeman, Andy et al

Poster (2018, October 26)

This study evaluated the effectiveness of vaccination against BTV-8 in Belgium and has shown that the interaction between the time since the first injection and the second injection of the primo ... [more ▼]

This study evaluated the effectiveness of vaccination against BTV-8 in Belgium and has shown that the interaction between the time since the first injection and the second injection of the primo-vaccination is significantly associated to the change in serology showing vaccine efficiency induces antibodies production. This study also clearly confirms the benefit of vaccination by reducing economic impact of treatment and production losses, especially in dairy cattle herds. [less ▲]

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See detailPyocolpos in a spayed queen with imperforate hymen: a case report
Egyptien, Sophie ULiege; Shimizu, Naomi ULiege; Anne-Archard, Nicolas ULiege et al

Poster (2018, October 26)

A 1-y-old sterilized queen was presented for dysuria. Abdominal palpation elicited pain and revealed a firm, well-circumscribed mass dorsal to the bladder. Ultrasonography confirmed a caudal fluid filled ... [more ▼]

A 1-y-old sterilized queen was presented for dysuria. Abdominal palpation elicited pain and revealed a firm, well-circumscribed mass dorsal to the bladder. Ultrasonography confirmed a caudal fluid filled abdominal structure extending into the pelvic cavity, displacing the colon dorsally and the urethra ventrally. Retrograde vagino-urethrography showed contrast in the vestibule, urethra and urinary bladder. Imperforate membrane at the vestibulo-vaginal junction with secondary vaginal distension was highly suspected. During surgery, a distended by purulent content vagina was observed, sub-total vaginectomy was performed. Bacterial culture showed Enterobacter cloacae. Definitive diagnosis of imperforate hymen is usually achieved by vaginoscopy. Retrograde vagino-urethrography can be used in some cases. This is the first report of imperforate hymen in the queen and also is the first case of pyocolpos. Origin of infection remains unclear. Contamination during neutering or via partial perforation of the hymen may be suspected. Enterobacter cloacae is a Gram - opportunistic pathogen of the urogenital tract of humans and animals. It is involved in multidrug-resistance spreading but its prevalence and clinical impact in veterinary medicine is unknown. In conclusion, this first report of persistent hymen in the queen highlights vagino-urethrography usefulness for diagnosing imperforate hymen in small patients, as well as the inclusion of congenital abnormality in the differential diagnosis of dysuria and the feasibility of sub-total vaginectomy by abdominal approach. Finally, it raises the question of Enterobacter cloacae’s implication in nosocomial infection in veterinary medicine. [less ▲]

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See detailLong-term outcome of the transobturator vaginal tape inside out (TVT-O) for the treatment of urethral sphincter mechanism incompetence in female dogs
Hamon, Martin ULiege; Hamaide, Annick ULiege; Noël, Stéphanie ULiege et al

Poster (2018, October 26)

Urethral sphincter mechanism incompetence (USMI) is the most common cause of acquired urinary incontinence in female dogs. Surgery is recommended if the animal does not respond to medical treatment or ... [more ▼]

Urethral sphincter mechanism incompetence (USMI) is the most common cause of acquired urinary incontinence in female dogs. Surgery is recommended if the animal does not respond to medical treatment or becomes refractory, if side effects develop or if owners are reluctant to administer long-term medication. Stress urinary incontinence in women is mainly treated surgically by vaginal placement of suburethral slings, including the transobturator vaginal tape inside out. This technique was reported in female dogs in 2010 and short-term results were promising. The objective of the present study was to evaluate the long-term outcome of the TVT-O in female dogs. TVT-O tape was inserted in 12 incontinent bitches diagnosed with USMI. Follow-up information was evaluated by a telephone questionnaire and a continence score was attributed. One year after surgery, 7 of 12 dogs were completely continent (58%). Two dogs were removed from the long-term analysis (1 dead and 1 lost). At a median follow-up time of 85 months (range 28 to 95 months), 4 /10 dogs were completely continent without medical treatment. Incontinence recurred in 6 dogs at a median time of 2 months after surgery (range 1 to 20 months). Among those, 4/6 regained continence and 2/6 had sporadic episodes of incontinence, with additional medical treatment. No postoperative complications were encountered. TVT-O alone was successful in maintaining long term continence in 40% of the dogs. Additional postoperative medical treatment was effective in restoring continence in another 40 % of dogs. TVT-O provides an alternative treatment of USMI in female dogs, that is safe and less invasive than standard surgical techniques. [less ▲]

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