References of "Poster"
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See detailAntimalarial Activity of Novel Substituted N-Arylcinnamamides
Degotte, Gilles ULiege; Strharsky, Tomas; Kos, Jiri et al

Poster (2022, July)

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See detailDeciphering the role of the GPR101 orphan receptor in growth hormone hypersecretion
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine et al

Poster (2022, April)

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See detailAnalyse préliminaire de la diversité morphologique des otolithes chez les téléostéens au moyen de la morphométrie géométrique 3D
Van Damme, Arthur ULiege; Frederich, Bruno ULiege; Fischer, Valentin ULiege et al

Poster (2022, March)

L’oreille interne des téléostéens est un organe stato-acoustique complexe composé de trois canaux semi-circulaires et de trois vésicules (saccule, utricule, lagena) abritant chacune un otolithe (sagitta ... [more ▼]

L’oreille interne des téléostéens est un organe stato-acoustique complexe composé de trois canaux semi-circulaires et de trois vésicules (saccule, utricule, lagena) abritant chacune un otolithe (sagitta, lapillus, asteriscus) reposant sur leur épithélium sensoriel, les maculae. Chez les non-otophysiens, la sagitta est l’otolithe le plus grand. Elle est reconnue comme étant spécifique ce qui participe à leur large diversité de forme. À l’heure actuelle, malgré plusieurs études ayant tenté de lier des données morphométriques en 2D avec la phylogénie, des traits éthologiques, écologiques et d’histoire de vie, la forme de cet otolithe ne trouve toujours pas d’explication. Cependant, nous pouvons à présent profiter des avancées en acquisition de données 3D et en morphométrie géométrique pour les appliquer sur des reconstructions en 3D d’otolithes et affiner des tests d’hypothèses écomorphologiques dans un contexte d’analyse comparative à large échelle. De larges bases de données, comme celle de MorphoSource (https://www.morphosource.org/), regroupent plusieurs milliers de téléostéens scannés à haute résolution en libre accès qui peuvent être aisément utilisés dans des études comparatives à grande échelle. Ainsi, durant cette étude préliminaire, nous proposons (1) d’appliquer une technique de projection de semi-landmarks (SLM) en haute densité pour couvrir la surface des sagittae tout en testant la sensibilité de la quantification de leur forme en faisant varier la densité de SLM (500, 1000 et 2000) et (2) de représenter la disparité des sagittae dans un contexte phylogénétique. Des scans de 45 spécimens issus de 29 ordres de téléostéens non-otophysiens avec une représentation particulière des clades Carangaria et Scorpaeniformes ont été acquis depuis MorphoSource. Les sagittae ont ensuite été reconstruites avec le programme Amira, puis les points ont été projetés sur les modèles obtenus permettant ainsi de caractériser les formes des sagittae par un ensemble de données cartésiennes. La superposition de ces coordonnées a été faite à l’aide d’une analyse GPA (Generalized Procrustes Analysis). Une analyse en composante principale des variables de formes a permis de visualiser graphiquement la dispersion des espèces dans l’espace de forme des sagittae. Les otolithes sont séparés par leur rapport longueur/largeur croissant le long du premier axe, allant de formes élevées/lobées à elliptiques/fusiformes, sans révéler de signal phylogénétique particulier. Les projections de points, le traitement des données et les analyses statistiques ont été réalisées sous la plateforme R. L’augmentation de la densité de SLM n’a pas d’effet notable sur la répartition de l’espace des formes. Cette analyse préliminaire de structures en 3D permet de valider notre approche pour tester de futures hypothèses écomorphologiques à large et petite échelles phylogénétiques. [less ▲]

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See detailEffects of noise and a speaker’s impaired voice quality on spoken language processing in school-aged children: a systematic review and meta-analysis
Schiller, Isabel ULiege; Remacle, Angélique ULiege; Durieux, Nancy ULiege et al

Poster (2022, January 20)

Classroom listening conditions are often characterized by high levels of background noise. Beyond that, every second teacher develops voice disorders during their career, meaning that many pupils are ... [more ▼]

Classroom listening conditions are often characterized by high levels of background noise. Beyond that, every second teacher develops voice disorders during their career, meaning that many pupils are taught in impaired (e.g., hoarse or breathy) voices. This systematic review and meta-analysis aims at understanding how background noise and a speaker’s impaired voice quality affect spoken language processing in 6-18-year-old children. We review 31 studies on the impact of noise and/or impaired voice on children’s answer accuracy and response time (RT) in listening tasks. A classification of the findings is presented in the SPADE framework, featuring three processing dimensions: speech perception, listening comprehension, and auditory working memory. Statistical analyses reveal that noise compromises children’s accuracy in listening tasks within each of these dimensions (Cohen’s d between –0.67 and –2.65), and that listening to an impaired voice impedes children’s accuracy in listening comprehension tasks (d = –0.35). RT data is too scarce to allow firm conclusions. Several factors related to the listener, task, environment, and type of exposure are identified as moderators of the impact of noise and impaired voice. Interaction effects between noise and impaired voice remain unclear and need further investigation. Our results highlight that acoustically adverse listening conditions disrupt children’s spoken language processing and may potentially hinder their academic achievement at school. [less ▲]

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See detailLes soins psychologiques de première ligne en Belgique : Le profil des PPL et l'orientation des patients par les médecins généralistes et les PPL
Kinard, Annabelle ULiege; Glowacz, Fabienne ULiege

Poster (2021, December 20)

Introduction. Les soins psychologiques de première ligne ont été implémentés en Belgique entre Janvier et Avril 2019 dans le cadre de la réforme de santé mentale « psy 107 ». Ceux-ci s’inscrivent dans une ... [more ▼]

Introduction. Les soins psychologiques de première ligne ont été implémentés en Belgique entre Janvier et Avril 2019 dans le cadre de la réforme de santé mentale « psy 107 ». Ceux-ci s’inscrivent dans une tendance plus large de renforcement des soins primaires au niveau international. L’objectif de ce poster est d’étudier la reconnaissance diagnostique en santé mentale ainsi que la concordance de l’orientation entre les psychologues et orthopédagogues de première ligne (PPL) et les médecins généralistes envers ce nouveau dispositif de soin. Méthode. Une enquête en ligne a été diffusée auprès de l’ensemble des PPL (n=641) dans un réseau adulte en Septembre 2020 par l’intermédiaire des coordinateurs de réseau et en Juin 2021 pour les médecins généralistes. Notre échantillon se compose de 310 PPL et de 270 médecins généralistes. Les vignettes cliniques de Jorm et al. (1999) utilisée largement en Australie pour étudier la mental health litteracy ont été utilisée au sein de ces questionnaires. Les participants devaient identifier une situation de dépression et de schizophrénie décrite dans les vignettes. À partir de celles-ci, ils leur étaient demandés de mentionner si une orientation vers les soins psychologiques de première ligne serait indiquée ou non ainsi que d’argumenter leur position. Résultats. La majorité (95,7%) des médecins généralistes mentionnent avoir déjà orienté un patient vers les soins psychologiques de première ligne. La dépression est majoritairement reprise comme étant une cible des soins psychologiques de première ligne tant pour les PPL (99,6%) que pour les médecins généralistes (71,1%). Les médecins allant à l’inverse de cette position renseignent la volonté d’accompagner eux-mêmes le patient dans la mesure du possible avant de réorienter. La schizophrénie quant à elle est mentionnée comme n’étant pas indiquée par une majorité des PPL (79%) et des médecins généralistes (71,1%) mais fait davantage l’objet de controverse. Les psychologues ne partageant pas cet avis mettent en avant leur capacité à prendre en charge ces patients et leur permettre de bénéficier de ces soins plus accessibles. Conclusion. Une concordance dans les orientations émerge de nos résultats entre les deux groupes professionnels. Ceci traduit une mise en application de la convention telle qu’elle avait été décrite pour la majorité malgré quelques divergences d’argumentation [less ▲]

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See detailDyrosaurids have a unique postcranial anatomy
Scavezzoni, Isaure ULiege; Fischer, Valentin ULiege

Poster (2021, December 19)

Dyrosauridae is a family of neosuchian crocodyliformes known from both terrestrial and aquatic environments across the Cretaceous–Palaeogene transition. The postcranium of dyrosaurids comprises ... [more ▼]

Dyrosauridae is a family of neosuchian crocodyliformes known from both terrestrial and aquatic environments across the Cretaceous–Palaeogene transition. The postcranium of dyrosaurids comprises astonishing features such as their vertebra with hypapohyses and tall neural spines, their well-developed pelvic girdles, and stout limbs, etc. However, their postcranial anatomy has long been overlooked, obscuring both their locomotive adaptations and the magnitude of their disparity. From this point of view, we thoroughly analysed the entire anatomy of the key dyrosaurids Congosaurus bequaerti and Hyposaurus natator, along with other extant (Crocodylia) and extinct Crocodyliformes (Thalattosuchia). In parallel, we also produced a comprehensive dataset of 187 traits on 27 taxa, largely covering the cranium and postcranium of exemplar crocodyliforms. These data were analysed following principal coordinate analysis (PCoA) to envision the morphospace occupation of Dyrosauridae, Thalattosuchia and Crocodylia. Our data report that Dyrosauridae displays a unique postcranial architecture, considerably contrasting with that of Crocodylia, but in some ways not totally dissimilar from that of Thalattosuchia. Consequently, extant crocodylians might not represent a good functional analogue for extinct crocodyliformes. Furthermore, phylogenetic and disparity analyses would benefit from the employment of more postcranial data. [less ▲]

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See detailNot a jaguar after all: affinities and morphology of Panthera gombaszoegensis
Chatar, Narimane ULiege; Michaud, Margot; Fischer, Valentin ULiege

Poster (2021, December 18)

Panthera gombaszoegensis is a fossil pantherine from the Pleistocene of Eurasia. Due to dental similarities with the jaguar (Panthera onca), it was considered to be the closest ancestor to the modern ... [more ▼]

Panthera gombaszoegensis is a fossil pantherine from the Pleistocene of Eurasia. Due to dental similarities with the jaguar (Panthera onca), it was considered to be the closest ancestor to the modern jaguar and was even sometimes considered as a subspecies of jaguar. Our knowledge of this taxa is, however, limited by the scarcity of cranial remains, which has made it difficult to properly assess the phylogenetic affinities and possible ecological role of this taxon. We describe a new cranium from Belgium and computed morphometric analyses on the cranium and dentition of extinct and extant pantherines. While the lower dentition of P. gombaszoegensis is indeed similar to that of P. onca, those similarities are not recovered on other parts of the skull. Some cranial traits of P. gombaszoegensis resemble those of other pantherines, especially larger species such as the tiger P. tigris. Some similarities with generalist taxa such as P. tigris, P. leo or P. pardus in the skull of P. gombaszoegensis suggest a generalist diet, adapted to a wide prey spectrum. The first ever phylogenetic assessment of the phylogenetic position P. gombaszoegensis places this taxon closer to P. tigris than to P. onca, which considerably simplifies the biogeographic history of pantherines. [less ▲]

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See detailThe importance of inland water CO2, CH4, N2O to summertime greenhouse gas exchange with the atmosphere in Arctic tundra lowlands
Dean, J; Martyn Rosco, M; Borges, Alberto ULiege et al

Poster (2021, December 13)

Inland waters in Arctic landscapes have carbon and nutrient cycles that are closely coupled to terrestrial processes. These waters act as conduits of terrestrial material by transporting, actively storing ... [more ▼]

Inland waters in Arctic landscapes have carbon and nutrient cycles that are closely coupled to terrestrial processes. These waters act as conduits of terrestrial material by transporting, actively storing and processing it, subsequently emitting greenhouse gases (GHG) carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) to the atmosphere. To quantify the role inland waters play in Arctic GHG budgets, it is necessary to quantify the importance of GHG emissions from all types of inland waters relative to the terrestrial sink capacity at the landscape scale. Here, we present simultaneous measurements of dissolved CO2, CH4 and N2O from lake, pond and low order fluvial systems across three summers in the Indigirka River lowlands, northeast Siberia (2015-2017). During May-July 2017, the region experienced a large flood of which we captured the tail end. Using remote sensing information to up-scale inland water emissions, we calculated combined carbon (C) emissions, CO2-C and diffusive CH4-C, that ranged from 2.6 to 2.8 Mg C d-1 (95% CI) during a non-flood scenario (e.g 2015-2016), and ranged from 3.6 to 3.9 Mg C d-1 (95% CI) during a flood scenario (e.g 2017), when an estimated 7% of the study area was flooded. Integrating these values into the landscape C exchange of the study area offset the landscape C sink during summer by 22-32%. Inland water N2O emissions were negligible in comparison to CO2 and CH4 emissions, in terms of their radiative forcing, accounting for < 0.005% of landscape GHG exchange in CO2-equivalents. Upscaling our landscape-scale results to larger areas indicates that in the northeast Siberian Arctic tundra, inland water CO2 and CH4 emissions are an important component of regional carbon budgets. For example, at the scale of the output resolution of land surface models such as CLM 4.5 (~45267 km2), our estimate of inland water C emissions offset the landscape carbon sink by ~2%. This may warrant undertaking the complicated task of including inland water carbon processes into these large land models. [less ▲]

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See detailGround-based MAX-DOAS observation of NO2 and H2CO over Kinshasa and comparisons with GEOS-Chem model data and TROPOMI observation
Yombo Phaka, Rodriguez ULiege; Mahieu, Emmanuel ULiege

Poster (2021, December 13)

Africa experiences an explosive human population growth, leading to different environmental issues. In particular, many African cities are heavily affected by air pollution. It is therefore essential to ... [more ▼]

Africa experiences an explosive human population growth, leading to different environmental issues. In particular, many African cities are heavily affected by air pollution. It is therefore essential to monitor the concentrations of various polluting species such as NO2, HCHO, O3 and aerosols, which have a direct impact on human health. The sources of pollutants in Africa are different from those found in many industrial areas. For example, forest fires and household cooking largely contribute to the NO2 and HCHO concentrations in Central Africa. However, many large African cities do not have atmospheric measurement instruments that perform continuous measurements. From May 2017 to early November 2019, a single axis DOAS instrument was installed and performed measurements at the University of Kinshasa (UniKin: -4.42° S, 15.31° E). This installation is the result of a close collaboration between the Belgian Institute for Space Aeronomy (IASB) and the UniKin Faculty of Sciences. Studies based on measurements made with this instrument have demonstrated the presence of a clear yearly cycle of the NO2 concentration with higher values in the dry season (Yombo et al., 2021). With such a low-cost instrument, the information content of the measurements is very limited and the uncertainties of the measurements rather high. . In November 2019, the single axis instrument was replaced by a new MAX-DOAS (multi-axis differential optical absorption spectroscopy) system built at the IASB, increasing substantially the information content of the measurements. These first Max-DOAS measurements are used to retrieve NO2 and HCHO contents over the city of Kinshasa, utilizing the harmonized FRM4DOAS analysis facility. The two years of MAXDOAS vertical column results of these two molecules are compared to OMI and TROPOMI data. They constitute important validation points in central Africa which currently lacks validation data and hence, these measurements will contribute to improvements of the a priori shape in the lower troposphere. Further, we compare this data set to specific GEOS-Chem chemistry transport model simulations allowing some specific investigations of source attribution. To our knowledge, these DOAS measurements yielded the first multiyear dataset of air quality measurements performed in Kinshasa. [less ▲]

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See detailLe médicament anti-angiogénique Sunitinib contrarie le conditionnement ischémique rénal induit par l’irradiation
Khbouz, Badr ULiege; Pinto Coelho, Tiago ULiege; LALLEMAND, François ULiege et al

Poster (2021, December 08)

Introduction: L’irradiation corporelle induit un conditionnement ischémique rénal(CIR) chez la souris. Les mécanismes cellulaires sont méconnus, hormis un possible rôle de la néo-angiogenèse. Nous ... [more ▼]

Introduction: L’irradiation corporelle induit un conditionnement ischémique rénal(CIR) chez la souris. Les mécanismes cellulaires sont méconnus, hormis un possible rôle de la néo-angiogenèse. Nous étudions les voies impliquées dans l'irradiation rénale. Ensuite, nous analysons l'impact fonctionnel sur les reins avant ischémie rénale/reperfusion(IR). Enfin, nous testons si l'inhibition de l'angiogenèse par le Sunitinib empêche le CIR associé à l'irradiation Méthodes: Exp1. Une irradiation rénale(8Gy) est réalisée chez des C57bl/6 mâles(n=10). Un mois plus tard, l'ARN rénal total est extrait pour un RNAseq comparatif. Exp2. À 7-14-28 jours post-irradiation, les reins droits sont néphrectomisés et les reins gauches subissent une ischémie(30min)/reperfusion(48h) (n=8/timing). Exp3. Suivant le même protocole d'I/R à J14, 3 groupes sont comparés(n=8/groupe): 1/irradiation; 2/irradiation et gavage au Sunitinib de J2 à J13; 3/groupe témoin sans irradiation ni gavage Résultats: Exp1. RNAseq montre une up-régulation de l'angiogenèse. L’expression de VEGF et CD31 est augmentée au niveau ARNm et protéique dans les reins irradiés. Exp2. Après IR à J14 post-irradiation, les taux sériques d’urée(BUN) et de créatinine(SCr) sont plus faibles chez les souris irradiées par rapport aux témoins(BUN:86,2±6,8 vs 454,5±27,2 mg/dl; SCr:0,1±0,01 vs 1,7±0,2mg/dl, p<0,01). L'infiltration rénale par les macrophages CD11b(187±32 vs 477±20/mm²) et F4-80(110±22 vs 212±25/mm²) est moindre dans le groupe irradié. L'expression de VEGF et CD31 est majorée dans les reins irradiés à partir de J14. Exp3. Après IR, les taux de BUN et de SCr dans le groupe irradié-exposé au Sunitinib sont similaires aux témoins(BUN 352,2±54,3 vs 408,4±54,9 mg/dl; SCr:1,5±0,3 vs 1±0,2 mg/dl) Conclusion: L'irradiation rénale induit l'activation de l'angiogenèse chez la souris et est associée à un CIR, avec fonction rénale préservée et inflammation atténuée post-IR. L'exposition au Sunitinib post-irradiation empêche ce CIR. [less ▲]

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See detailNiveau de sensibilité de la mineuse de la tomate (Tuta absoluta) à divers biopesticides
Sawadogo, Wendnéyidé Mathieu ULiege; Ahissou, Besmer Régis ULiege; Somda, Irénée et al

Poster (2021, December 04)

The tomato leafminer Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is a worldwide invasive pest of tomatoes that reached West Africa in 2010. Synthetic insecticides remain the most widely used method ... [more ▼]

The tomato leafminer Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is a worldwide invasive pest of tomatoes that reached West Africa in 2010. Synthetic insecticides remain the most widely used method of control, but several biological alternatives are being developed. In this work, we evaluated nine biopesticides (HN, 11.5 ml/l ; Piol, 13.61 ml/l ; Limosain, 6.8 ml/l ; Biopoder, 12.6 ml/l ; HNN+, 7.56 ml/l ; HNN++, 7.56 ml/l ; Bangr-pougo (BP), 200 ml/l ; Bangr-kièta (BK), 200 ml/l ; Bangr-pougo (BP) formulated in powder, 10 g/l), available in the West African market, for their ability to control T. absoluta. We followed the IRAC022 (Insecticide Resistance Action Committee) methodology, consisting in leaf/egg dip bioassay, to compare both the ovicidal and the larvicidal activity of these biopesticides, at various concentrations of active ingredients. We found, for each tested biopesticides, the larva lethal concentrations (LC) (8.2 - 41.14 ml/l) to be lower than those necessary to stop egg hatching (26.7 - 409.7 ml/l). Two products, both based on Azadirachta indica extracts and bark of Khaya senegalensis, showed high efficacy in reducing egg hatchability, at their recommended doses (200 ml/l and 10 g/l), with a calculated control failure likelihood (CFL) reaching 0%. These two products, together with a third one based on Mitracarpus scaber extracts, also showed the strongest larvicidal effects (CFL = 0%). All other tested biological insecticides showed significant efficiency but were found to be less effective at their recommended doses. Because the leafminer has developed resistance to most of the synthetic insecticide available on the market, we recommend that a proper communication is made toward West African tomato producers to encourage them to use the most efficient biological products available. [less ▲]

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See detailCriblage de pesticides homologués contre Tuta absoluta au Burkina Faso
Sawadogo, Wendnéyidé Mathieu ULiege; Somda, Irénée; Nacro, Souleymane et al

Poster (2021, December 04)

The South American tomato pinworm, Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is a leafminer species currently considered as one of the major pests of fresh tomatoes around the world. The species ... [more ▼]

The South American tomato pinworm, Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is a leafminer species currently considered as one of the major pests of fresh tomatoes around the world. The species settled in north Africa in 2007, before being observed in the entire continent. Widespread insecticide use has led to the emergence of resistant populations in South America and Europe, but no large-scale insecticide resistance assessment has been performed in Sub-Saharan Africa so far. In this study, we collected T. absoluta larvae (extraction of larvae from infested tomato leaves followed by their deposition on leaves of live tomato plants placed in a cage) in vegetable growing sites of Burkina Faso where the pest was first detected in 2016. These sites are Ouahigouya (northern region), Goué and Loumbila (central plateau) and Pindga (central-southern region). Acute toxicity of the all-available molecules in Burkina Faso was evaluated in the laboratory on F1 individuals, including acetamiprid, abamectin, spinosad, cypermethrin, chlorpyrifos, λ-cyhalothrin, deltamethrin, and Bacillus thuringiensis. No LC50 differences among T. absoluta populations were highlighted, except for Bacillus thuringiensis. Insects were still highly susceptible to abamectin [LC50 < 0.4 mg/L; Control failure likelihood (CFL) =−25%], spinosad (LC50 < 0.6 mg/L; CFL = -25%) and chlorpyrifos-ethyl (LC50 between 254 and 458 mg/L; CFL =−15%), but were less susceptible to acetamiprid (CFL ranging from 72% to 91%), cypermethrin (CFL = 80%), λ-cyhalothrin (CFL =79%), and deltamethrin (CFL ranging from 51% to 66%), with LC50 values for these insecticides ranging between 100 and 525 mg/L. Pending a proper communication strategy, we hope this work could help producers avoiding the most inefficient active substances. [less ▲]

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See detailNesidiocoris tenuis au Burkina Faso: Distribution, capacité de prédation et sensibilité aux insecticides
Sawadogo, Wendnéyidé Mathieu ULiege; Mano, Elias; Ahissou, Besmer Régis ULiege et al

Poster (2021, December 04)

Tuta absoluta (Lepidoptera: Gelechiidae) is a worldwide invasive insect species, considered a major pest of tomato. It has recently established in Burkina Faso, where chemical control remains the only ... [more ▼]

Tuta absoluta (Lepidoptera: Gelechiidae) is a worldwide invasive insect species, considered a major pest of tomato. It has recently established in Burkina Faso, where chemical control remains the only affordable option to limit damage. Nesidiocoris tenuis (Hemiptera: Miridae) is commercialised as a biological agent to control this pest in other parts of the world. But no literature is available on this predator in Burkina Faso. Therefore, in this study, we (1) scoured the country to determine its distribution and abundance in tomato fields, (2) verified its ability to consume T. absoluta eggs in two scenarios: the first one where N. tenuis has to search for the eggs on the plants and the second one in Petri dishes where the eggs are placed and N. tenuis could consume the eggs at will (3) measure the susceptibility of both insects to insecticides (two synthetic insecticides, three bio-bacterial insecticides and eight plant extracts) using the IRAC 022 method. It appears that, N. tenuis was found in 13 regions of the country with very interesting densities in some tomato fields (up to 80 individuals / m2). All stages of N. tenuis consume T. absoluta eggs and the number of eggs consumed depends on the stage of development and mode of egg delivery. When he has to look for some on the leaves, the adults find about 20 eggs to consume per day, while for an availability and consumption at will of eggs, he consumes about 45 eggs per day. Abamectin, emamectin benzoate, spinosad, spinetoram were very toxic for both T. absoluta and N. tenuis. In contrast, biopesticides including Bacillus thuringiensis, neem oil, Cleome viscosa, Ocimum basilicum and Cassia occidentalis were found to be compatible with N. tenuis while controlling T. absoluta. Based on our results, we recommend that through training for growers, they can be shown the importance of N. tenuis in the management of T. absoluta. We therefore recommend the use of biopesticides in combination with N. tenuis in the control of T. absoluta in Burkina Faso. [less ▲]

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See detailSomething Old, Something New: Addressing Technological Innovation Through the Lens of Time
De Cooman, Jérôme ULiege

Poster (2021, December 03)

New technologies do not always raise new legal issues. We should therefore focus on technological change rather than discussing new technologies. What is new in time might not be new in kind. Filiation ... [more ▼]

New technologies do not always raise new legal issues. We should therefore focus on technological change rather than discussing new technologies. What is new in time might not be new in kind. Filiation between outer space law and cyberspace law illustrates well this argument. Acknowledging historical continuity, we assess the relation between bioethics and the regulation of artificial intelligence. [less ▲]

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See detailÉtude des dérives métaboliques pour l’identification des patients Covid-19 à risque
BOUTIN, Ronan; ROLLAND, Jakez; CODET, Marie et al

Poster (2021, December 01)

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See detailSusceptibilité de Spodoptera frugiperda aux insecticides et calcul de la probabilité d'échec de traitement au Burkina Faso
Ahissou, Besmer Régis ULiege; Sawadogo, Wendnéyidé Mathieu ULiege; Bokonon-Ganta, Aimé H. et al

Poster (2021, December 01)

The fall armyworm, Spodoptera frugiperda Smith (Lepidoptera: Noctuidae) has recently invaded sub-Saharan African countries. It has been causing significant losses to maize, pearl millet, sorghum, rice ... [more ▼]

The fall armyworm, Spodoptera frugiperda Smith (Lepidoptera: Noctuidae) has recently invaded sub-Saharan African countries. It has been causing significant losses to maize, pearl millet, sorghum, rice, and other crops since 2016. Several insecticides have been promoted, but farmers have reported control failures. In this work, we collected seven fall armyworm populations in as many maize-producing areas of Burkina Faso. We used the approved IRAC foliar bioassay protocol to evaluate the susceptibility of third instar larvae to six chemical insecticides commonly used by maize farmers, including different modes of action (active ingredient): acetylcholinesterase inhibitors (methomyl, chlorpyriphos-ethyl), sodium channel modulators (deltamethrin, lambda-cyhalothrin), chloride channel activators (emamectin benzoate, abamectin). Lethal concentrations and control failure likelihood (CFL, using Guedes' 2017 formula) were calculated for each population and active ingredient. For all seven populations of S. frugiperda, LC80 values are significantly higher than the manufacturer's recommended rates and CFL values are high, 66-100% for both pyrethroids (deltamethrin, lambda-cyhalothrin) and abamectin. In contrast, the LC80 values for emamectin benzoate emamectin benzoate (0.001 mg/l), methomyl (43 - 278 mg/l) and chlorpyrifos-ethyl (284 - 659 mg/l) are lower than the recommended rates. Emamectin benzoate, methomyl and chlorpyriphos-ethyl insecticides have a negligible risk of control failure (i.e. their CFL values are below 0%) and are the most efficient for the control of the fall armyworm in Burkina Faso. These active ingredients should be alternated in the control of the pest to delay the development of resistance. [less ▲]

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See detailInbred/outbred : quelle variabilité dans un modèle murin de la sensibilisation comportementale ?
Van Ingelgom, Théo ULiege; Didone, Vincent ULiege; Godefroid, Leeloo ULiege et al

Poster (2021, December 01)

« Les modèles murins consanguins varient moins que les modèles non-consanguins ». Ceci constitue un parfait exemple d’un postulat scientifique largement répandu qui semble être raisonnable alors qu’il est ... [more ▼]

« Les modèles murins consanguins varient moins que les modèles non-consanguins ». Ceci constitue un parfait exemple d’un postulat scientifique largement répandu qui semble être raisonnable alors qu’il est en grande partie incorrecte. Pourquoi ? Car la variabilité dépend grandement de ce que l’on mesure. Bien entendu, si nous nous basons uniquement sur le profil génétique seul, les lignées consanguines varient moins que celui des lignées non consanguines. C’est une vérité scientifique générale. Cependant, ce que la majorité des scientifiques omettent de préciser, c’est que le degré de variabilité de la quasi-totalité des mesures phénotypiques (comme le comportement) est comparable dans les deux populations. Alors pourquoi devrait-on privilégier l’usage des lignées plus distantes dans des études comportementales ? Car le comportement est rarement expliqué par le profil génétique seul. Le comportement est régi par l’interaction de multiples facteurs diversifiés qui varient entre eux, comme chez l’homme. Dans notre étude postulant des effets protecteurs de l’exercice physique sur le syndrome d’addiction alcoolique, nous pouvons évidemment prendre en compte les facteurs génétiques mais aussi environnementaux et surtout les facteurs de variabilité liés à la drogue elle-même. C’est ici que les souris non-consanguines ont leur utilité. C’est pour se rapprocher de cette homologie avec l’être humain. D’autant plus que la majorité des lignées consanguines ont des fragilités sanitaires, elles sont plus frêles et ont un indice de reproduction et un pourcentage de sevrage plus faibles. Ce sont des signes essentiels qui renseignent sur le fait qu’elles ne sont pas « normales ». Ce qui explique également pourquoi l’inceste est un tabou dans la société. Pour conclure, le but n’est pas d’inciter les chercheurs à bannir les modèles consanguins des recherches car ils ont leur grande utilité dans les études purement génétiques ou quand la souris constitue un modèle de pathologie connue, notre désir est justement de vous encourager à ne pas bannir les modèles génétiquement distants dans les recherches. C’est effectivement cette diversité génétique qui assure une plus grande généralisation des conclusions des études. Et comme nous l’avons entendu hier ici même, il est essentiel de rappeler que le problème de généralisation est actuellement au centre de la crise actuelle de la réplicabilité; et contrairement aux attentes, l’utilisation de souris non consanguines, plus robustes comme sujets de recherche pourrait améliorer la réplicabilité des résultats. [less ▲]

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See detailDiscrete Aurora at Mars: Dependence on Upstream Solar Wind Conditions
Girazian, Z.; Schneider, N.; Milby, Z. et al

Poster (2021, December)

At Mars, discrete aurora are defined by their small spatial extent and general tendency to form near strong crustal magnetic fields. They are produced when precipitating electrons enter the upper ... [more ▼]

At Mars, discrete aurora are defined by their small spatial extent and general tendency to form near strong crustal magnetic fields. They are produced when precipitating electrons enter the upper atmosphere and collide with neutral molecules, causing them to emit ultraviolet radiation. The auroral emissions are routinely detected by MAVEN’s Imaging Ultraviolet Spectrograph (IUVS) during nightside periapsis limb scans. In this presentation, we present a statistical study of the IUVS dataset that shows how the discrete aurora detection frequency depends on upstream solar wind conditions at Mars. We find that the probability of detecting an aurora increases during times of high solar wind dynamic pressure and increased interplanetary magnetic field (IMF) strength. We also find that the IMF clock and cone angles control the detection frequency and locations of the aurora. These results provide useful constraints for future theoretical and modelling studies that attempt to explain the physics of discrete aurora at Mars. [less ▲]

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See detailEffets du moment de test et de paramètres méthodologiques sur le comportement et la cognition de la souris de laboratoire
Zaros, Aurélie ULiege; Ferrara, André ULiege

Poster (2021, December)

La plupart des espèces terrestres se sont adaptées au cycle nycthéméral en développant des rythmes circadiens physiologiques et comportementaux. La lumière (ou zeitgeber) est l’indice environnemental le ... [more ▼]

La plupart des espèces terrestres se sont adaptées au cycle nycthéméral en développant des rythmes circadiens physiologiques et comportementaux. La lumière (ou zeitgeber) est l’indice environnemental le plus important qui influence de nombreux aspects tels que l'activité, la vigilance, la température corporelle, la régulation hormonale ou la potentialisation à long terme. Les souris font partie des principaux animaux employés dans les laboratoires de neurosciences comportementales et de recherche préclinique. Bien que nocturnes, ces dernières sont généralement testées pendant leur phase de repos, le jour, et sous des conditions lumineuses classiques. Bien que cette pratique soit plus commode pour l'expérimentateur, toute perturbation du cycle veille-sommeil (comme les manipulations diurnes liées à la maintenance ou à l’expérimentation), pourrait générer un certain stress pour l'animal et affecter son bien-être et aussi mener à la production de données peu fiables. Ainsi, le moment du test pourrait constituer une variable importante affectant le comportement animal et par là certaines conclusions que nous faisons sur les processus cognitifs. Il semblerait que les rongeurs soient moins anxieux durant la phase sombre, cependant, un manque de données relatif à l'effet du moment de test sur le comportement a récemment été mis en avant. En outre, plusieurs études évaluant les effets du moment de test sur diverses capacités cognitives ont montré des résultats contradictoires ; ces écarts peuvent s'expliquer par divers aspects méthodologiques tels que les paramètres liés à la procédure (comme les conditions d'éclairage au moment du test, l’espèce, voire la souche étudiée) mais également par la manière de recueillir et d’interpréter les données comportementales. Dans cette étude, nous nous sommes concentrés sur un test d'anxiété (le labyrinthe en croix surélevé, EPM) et sur un test de mémoire (le test de reconnaissance d’objets, ORT). Nous avons comparé les performances de quatre groupes de sujets testés à 4 moments différents du cycle circadien veille-sommeil (deux dans la phase active et deux dans la phase de repos) pour déterminer s'il y avait un moment de test plus approprié pour l'expérimentation animale où les souris montreraient une anxiété réduite et de meilleures performances. Nous montrons que la manière d'analyser le comportement peut affecter la conclusion concernant l'influence du moment du test sur la performance et suggérons que les paramètres procéduraux et d’analyses soient davantage considérés et justifiés afin d’aboutir à de meilleures conclusions relatives au comportement de l’animal. [less ▲]

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See detailAssessing the performance of high capacity submersible pumps used in waterways: experimental tests and computational model calibration
Hardy, Joris ULiege; Dewallef, Pierre ULiege; Erpicum, Sébastien ULiege et al

Poster (2021, December)

Worldwide, navigation is made possible in artificial waterways thanks to the support of a considerable number of high capacity pumps. In terms of energy-efficiency, many of these pumps do not operate ... [more ▼]

Worldwide, navigation is made possible in artificial waterways thanks to the support of a considerable number of high capacity pumps. In terms of energy-efficiency, many of these pumps do not operate optimally. Main reasons for this include pump oversizing and the absence of variable speed drive. In this communication, we present a hybrid modelling approach for assessing the actual performance of high capacity submersible pumps used in waterways. It is based on a novel, large experimental test bench and a computational model of the motor and pump system. The computational model achieves an accuracy of about 10% for predicting the flow rate, energy consumption and system efficiency. This hybrid tool may be valuably exploited to assess full scale pumping systems and lead to energy savings, for instance by improving the selection of the frequency applied to the motor considering the actual losses in suction and discharge pipes. [less ▲]

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See detailMars and Venus Dayglow Studies Based Upon Laboratory Aeronomy from Electron Impact of CO2 for analysis of UV Observations by MAVEN, EMM, MEx, and VEx
Lee, R.; Ajello, J.; Veibell, V. et al

Poster (2021, December)

We have developed a laboratory aeronomy program at the University of Colorado to study electron impact fluorescence of the Cameron Bands CO(a 3Π → X 1Σ+; 180-260 nm), the First-Negative (1NG) Bands CO+(B ... [more ▼]

We have developed a laboratory aeronomy program at the University of Colorado to study electron impact fluorescence of the Cameron Bands CO(a 3Π → X 1Σ+; 180-260 nm), the First-Negative (1NG) Bands CO+(B 2Σ+ → X 2Σ; 180-320 nm), the Fourth-Positive (4PG) Bands CO(A 1Π → X 1S+ ; 111-280 nm), and UV doublet CO2+ (B 2Σ → X 2Πg; at 288.3 and 289.6 nm) in the FUV and MUV (Far and Middle UltraViolet) from CO2, to match the spectral region of present and future spacecraft equipped to observe the UV dayglow of Mars (100-300 km). We have constructed a large vacuum system apparatus that has measured the emission cross sections of the strongest optically-forbidden transitions found in the Mars airglow and aurora, the Cameron Bands, as well as perturbed UV doublet and 4PG Bands. The chemistry of the upper atmospheres above 100 km in the evolution of Mars and Venus can be determined from the observation of the UV airglow spectra by MAVEN IUVS (Imaging UltraViolet Spectrograph) spanning 110-340 nm and by MEx SPICAM (Spectroscopy for Investigation of Characteristics of the Atmosphere of Mars) covering 118-320 nm. We emphasized the study of the Cameron Band emissions from electron impact dissociative excitation of CO2, an uncertain physical process in the ionosphere of Mars. Based on our current cross section measurements, previous estimates of Cameron Band emission cross sections are in error by a factor of three or more, and forward modeling codes of the Mars dayglow have not been accurate in the MUV in the past due to errors in these cross sections that are used to calculate excitation rates. The rotational levels of the CO a-state are found to be long-lived with a lifetime of ~1-5 ms, a lifetime measured from the laboratory radial glow profile about the electron beam and the additional intensity from the UV doublet emission from B~A state coupling. We plan to furnish absolute emission cross sections (cascade + direct excitation) from threshold (~10 eV) to 300 eVfor CO and CO2, a set of fundamental physical constants for electron transport codes such as AURIC (Atmospheric Ultraviolet Radiance Integrated Code; Evans et al., 2015) used in the analysis of dayglow spectra from the Martian dayglow and aurora by the MAVEN imaging spectrometer, Emirates Mars Mission, and SPICAM, as well as the Venus dayglow by SPICAV. [less ▲]

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See detailA Search for Spectral Variations in Auroral Emissions from Mars
Pickerill, A.; Schneider, N.; Johnston, B. et al

Poster (2021, December)

The Imaging Ultraviolet Spectrograph (IUVS) instrument onboard the MAVEN mission has been used to study several forms of aurora in the atmosphere of Mars; discrete aurora, discovered by the SPICAM ... [more ▼]

The Imaging Ultraviolet Spectrograph (IUVS) instrument onboard the MAVEN mission has been used to study several forms of aurora in the atmosphere of Mars; discrete aurora, discovered by the SPICAM instrument on Mars Express, as well as two other forms discovered by MAVEN/IUVS referred to as diffuse aurora and proton aurora. Each type of aurora can be identified through unique spectral characteristics. In particular, discrete aurora events are ultraviolet emissions spread variably throughout Mars’ upper atmosphere, and are strongly correlated to Mars’ crustal magnetic field. Discrete aurora events can be identified by strong emissions of CO Cameron bands, and slightly weaker emissions of CO2+ Ultraviolet Doublet. Based on recent work from our group, we expect to see a ratio of approximately 7 between these two emissions. However, several exceptions display spectral features that do not agree with characteristics of any of the currently known aurora types. These observations show the same two emissions as discrete aurora events. However, the ratio between the CO Cameron bands and CO2+ Ultraviolet Doublet is much higher than expected, ranging from a ratio of 10 to over 500. We have collected the observations containing these variations and will search for patterns and trends among them, such as proximity to the terminator, locations relative to crustal fields, or timing relative to space weather events. Using these trends, we will discuss possible explanations for the differences between this data and common discrete aurora observations. [less ▲]

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See detailSeasonal and Diurnal Variation in Vertical Profiles of the Martian Nitric Oxide Nightglow Layer
Milby, Z.; Schneider, N.; Jain, S. et al

Poster (2021, December)

The nitric oxide (NO) nightglow is a recombination reaction rate which traces flux between from the nightside Martian thermosphere to the mesosphere. Brighter emission occurs where descending air brings ... [more ▼]

The nitric oxide (NO) nightglow is a recombination reaction rate which traces flux between from the nightside Martian thermosphere to the mesosphere. Brighter emission occurs where descending air brings molecules deeper into the mesosphere, so we can use the reaction rate as a tracer of the dynamics between Mars’ thermosphere and mesosphere. We derive vertical profiles of NO nightglow brightness from limb-scan spectra observed by the Imaging Ultraviolet Spectrograph (IUVS) on the Mars Atmosphere and Volatile Evolution (MAVEN) spacecraft. This data set has broad seasonal, latitudinal, and local-time coverage, allowing us to comprehensively characterize the behavior of the nightglow layer by latitude, local time, and season and even analyze waves and tidal structures, greatly expanding the results of previous limb scan studies. We also compare these observations to simulations from the LMD-MGCM and corresponding insights into altitude- and temporal-dependence of temperature, downwelling wind velocity, and atomic N and O densities. [less ▲]

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See detailScreened from head to toes: a multidisciplinary framework combining behavioral and skin-microbiome monitoring to improve amphibian conservation
Fieschi-Méric, Léa ULiege; Lesbarrères, David; Denoël, Mathieu ULiege

Poster (2021, December)

Faced with emerging deadly skin diseases, amphibians are currently the most endangered animal class on earth - with 40% of species threatened with extinction. Considering the urgency of the situation ... [more ▼]

Faced with emerging deadly skin diseases, amphibians are currently the most endangered animal class on earth - with 40% of species threatened with extinction. Considering the urgency of the situation, conservation authorities prioritize the establishment of ex-situ survival colonies, to ensure the persistence of the most vulnerable species and provide a possibility for their reintroduction after the mitigation of in-situ threats. Yet, while a lot of ex-situ collections of amphibians have been set around the world in the past decades, less than 12% of them have led to successfully established, self-sustaining, populations in the wild. A major challenge for these captive programs is to maintain evolutionary integrity, and research on how amphibians adapt to captivity is therefore crucial to increase the success of our conservation efforts. In this context, we set up an ex-situ collection of European newts and monitored their adaptation to long-term captivity employing a combination of behavioral and molecular tools. This new, multidisciplinary, approach enabled us to establish the first comprehensive personality study of an amphibian model, to describe the long-term reorganization of the amphibian skin microbiome (their first line of defense against pathogens) in captivity, and to investigate the interaction between host behavior and the composition of skin bacteria communities. This original framework could be used to evaluate and select the most appropriate individuals ahead of reintroductions, and ultimately enhance amphibian conservation programs. [less ▲]

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See detailImpact of the COVID-19 pandemic situation on HIV care in Liège, Belgium
El Moussaoui, Majdouline ULiege; Lambert, Nicolas ULiege; MAES, Nathalie ULiege et al

Poster (2021, November 30)

Background: The COVID-19 pandemic and associated containment measures dramatically affected the health care systems including the screening of human immunodeficiency virus and the management of people ... [more ▼]

Background: The COVID-19 pandemic and associated containment measures dramatically affected the health care systems including the screening of human immunodeficiency virus and the management of people living with HIV around the world by making the access to preventive care services and specific medical monitoring more difficult. Objective: To study the impact of the COVID-19 pandemic on the holistic care of people living with HIV in Liège (Belgium). Methods: In this retrospective observational study conducted in Liège University Hospital, we compared the out-patient follow-up of HIV-infected individuals as well as the number of new HIV diagnoses between 2019 and 2020 and between the different waves of the COVID-19 pandemic in 2020. Results: In 2020, when compared to 2019, we observed a significant decrease in the number of new HIV diagnoses, especially during the first wave of the pandemic, and in the number of consultations undertaken by sexual health services, psychologists and specialists in infectious diseases at our HIV clinic. We also observed a decrease in the number of viral load assays and blood CD4+ T-cells count analyses performed, although we found less patients with HIV plasma viral load above 400 copies per mL in 2020. Finally, we noted a significant reduction in terms of screening of our HIV-infected patients for hepatitis C, syphilis, colorectal and anal cancers and hypercholesterolemia. Conclusions: Our experience exhibits the deleterious impact of the COVID-19 pandemic on the HIV care and the need to implement new strategies to guarantee its continuum. [less ▲]

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See detailCLINICAL ASSESSMENT OF THE CERVICAL EXTENSOR MUSCLES DYSFUNCTIONS: A SCOPING REVIEW
Colman, David ULiege; Demoulin, Christophe ULiege; Perrier, Cyrielle et al

Poster (2021, November 27)

Neck pain is a major cause of disability worldwide and frequently associated with changes in muscle function. These changes, which may persist after the symptoms have disappeared, could explain recurrent ... [more ▼]

Neck pain is a major cause of disability worldwide and frequently associated with changes in muscle function. These changes, which may persist after the symptoms have disappeared, could explain recurrent or chronic neck pain. Given the functional alterations of the cervical extensors muscles (CEM) observed in subjects with neck pain1 , a review of the clinical ways to highlight these deficits is relevant. To identify the various clinical tests assessing CEM dysfunctions in patients with chronic neck pain (CNP). [less ▲]

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See detailEvaluation of ganglion cells loss in anterior ischaemic optic neuropathies
CHAPELLE, Anne-Catherine ULiege; RAKIC, Jean-Marie ULiege; PLANT, Gordon

Poster (2021, November 27)

To analyse the loss of thickness of ganglion cell complex (GCC, inner plexiform layer and ganglion cell layer) in patients with non-arteritic anterior ischaemic optic neuropathy (NA-AION).

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See detailActivation des connaissances sémantiques en mémoire de travail verbale : une investigation par IRM fonctionnelle
Querella, Pauline ULiege; Attout, Lucie ULiege; Fias, Wim et al

Poster (2021, November 26)

Si l’intervention de la mémoire à long terme (MLT) dans des tâches de mémoire de travail (MT) ne fait plus de débat, la nature de ces interactions reste encore peu comprise. L’objectif de cette étude IRMf ... [more ▼]

Si l’intervention de la mémoire à long terme (MLT) dans des tâches de mémoire de travail (MT) ne fait plus de débat, la nature de ces interactions reste encore peu comprise. L’objectif de cette étude IRMf était d’examiner dans quelle mesure le maintien temporaire de mots en MT utilise les mêmes représentations sémantiques que celles qui caractérisent les mots stockés en MLT. Les signaux cérébraux multivariés de quatre catégories sémantiques ont été déterminés via une tâche d’activation sémantique implicite (lecture de mots relevant de quatre catégories sémantiques). Ensuite, les sujets devaient maintenir des mots dans une tâche de MT, ces mots étant les noms des quatre catégories sémantiques de la tâche précédente. Via des analyses de patterns multi-voxels, nous avons pu distinguer les quatre catégories sémantiques à la fois dans la tâche d’activation sémantique et lors du maintien dans la tâche de MT (facteurs Bayésiens BF10>23268.92 et BF10>4.45, respectivement, pour toutes les classifications pour une comparaison par rapport au niveau du hasard). Par contre, en tentant de prédire les catégories sémantiques entre les deux tâches, les taux de prédiction ne dépassaient pas le niveau du hasard, indiquant que les signaux cérébraux multivariés associés aux noms de catégories sémantiques dans la tâche de MT et aux catégories sémantiques dans la tâche sémantique implicite diffèrent. Ces résultats indiquent que les représentations sémantiques profondes en MLT ne sont pas nécessairement activées dans des tâches de MT et suggèrent une intervention limitée de la MLT sémantique en MT. [less ▲]

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See detailSoutenir le développement langagier en maternelle : Identification des ingrédients actifs d’un dispositif de développement professionnel
Houben, Lauren ULiege; Bouchard, Caroline; Maillart, Christelle ULiege

Poster (2021, November 26)

Contexte : En Belgique, l’école maternelle est fréquentée la majeure partie de la journée par plus de 90% des enfants âgés de 3 à 5 ans. Ainsi, l’école représente un endroit propice à l’expérimentation ... [more ▼]

Contexte : En Belgique, l’école maternelle est fréquentée la majeure partie de la journée par plus de 90% des enfants âgés de 3 à 5 ans. Ainsi, l’école représente un endroit propice à l’expérimentation d’interactions de qualité permettant de soutenir le développement langagier. Toutefois, les pratiques enseignantes soutenant le langage y sont peu utilisées et pourraient être bonifiées (Leroy et al., 2017). Objectifs : Ce projet vise à identifier les ingrédients actifs d’un dispositif de développement professionnel permettant l’augmentation de pratiques soutenant le langage dans les classes de maternelle. Méthode : Selon une procédure de cas expérimentale (SCED), une intervention directe individualisée auprès de quatre enseignants de maternelle sera proposée par une orthophoniste. Afin d’obtenir un changement des pratiques enseignantes, cet accompagnement respectera les fonctions identifiées par le modèle de Biel et collaborateurs (2019) : 1) partage d'informations, 2) modélisation, 3) rétroaction, 4) guidance. Résultats : Le nombre d’occurrences des comportements soutenant le langage sera comptabilisé afin de déterminer le type d’intervention et le dosage approprié, en fonction des caractéristiques des enseignants. Conclusion : Il est souhaité que cette étude puisse documenter les orthophonistes et chercheurs sur le dosage et les ingrédients actifs d’un dispositif de développement professionnel ayant pour objectif l’augmentation du nombre de pratiques soutenant le développement langagier en maternelle. [less ▲]

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See detailVers une meilleure compréhension du séchage des boues à travers ses propriétés rhéologiques
Parra Angarita, Sergio Luis ULiege; Léonard, Angélique ULiege

Poster (2021, November 25)

La gestion et le traitement des boues d'épuration sont des défis croissants pour l'humanité, en 2020 au moins 13 millions de tonnes de boues sèches ont été générées dans l’Union Européenne. Les deux voies ... [more ▼]

La gestion et le traitement des boues d'épuration sont des défis croissants pour l'humanité, en 2020 au moins 13 millions de tonnes de boues sèches ont été générées dans l’Union Européenne. Les deux voies les plus courantes pour valoriser ce sous-produit sont l'incinération et la valorisation agricole, pour lesquelles le séchage thermique peut s'avérer intéressant. En général, l'efficacité du séchage convectif des boues est difficile à contrôler/prédire. Cependant, il a été déterminé que les processus de conditionnement et de déshydratation avant le séchage peuvent modifier les propriétés rhéologiques et texturales de la boue[1][2]. Celles-ci sont étroitement liées à l’efficacité du séchage [3][4]. Cette recherche vise à comprendre le rôle du conditionnement et de la déshydratation dans le changement des caractéristiques rhéologiques et texturales des boues et déterminer comment ces changements sont liés au comportement lors du séchage. [less ▲]

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See detailContribution to the development of a "low cost" process for sewage sludge stabilization.
Ben Hamed, Hajer ULiege

Poster (2021, November 25)

The quantity of sewage sludge (SS) requiring disposal in the EU is increasing. Sludge post treatment operations, such as stabilization, dewatering, drying and sustainable disposal options, have become a ... [more ▼]

The quantity of sewage sludge (SS) requiring disposal in the EU is increasing. Sludge post treatment operations, such as stabilization, dewatering, drying and sustainable disposal options, have become a global concern. Costs associated with these operations are exorbitant. Innovations targeting the management of sludge at minimal cost remains a challenge. Intergrating microalgae biomass production with SS stabilization process is a promising approach for the implementation of a “low cost” technology. Being photosynthetic microorganisms, microalgae can eliminate the CO2 emission, lower the need for mechanical aeration by providing oxygen via photosynthesis, scavenge resources (C, N and P), remove pathogens microorganisms, and convert solar energy into valuable biomass: a potential biofertilizer called Microalgae-Bacteria Flocs (MAB-Flocs). Thus, a general trends in changes of physicochemical properties of stable sludge, influencing SS dewatering and drying [less ▲]

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See detailIntegrating computational chemistry for the design of an automated nitroso species fluidic module learning
Bianchi, Pauline ULiege; Monbaliu, Jean-Christophe ULiege

Poster (2021, November 25)

The unique nitrogen-oxygen combination located next to a specific carbonated backbone of C-nitroso derivatives is responsible for a complex reactivity that renders them not only widely effective in ... [more ▼]

The unique nitrogen-oxygen combination located next to a specific carbonated backbone of C-nitroso derivatives is responsible for a complex reactivity that renders them not only widely effective in various processes, such as in nitroso Diels-Alder reactions, but also difficult to demystify [1]. Within this context, an automated interdisciplinary nitroso species fluidic module learning from nitrosoaldol reactions has been implemented (Figure 1). On the one hand, continuous flow technology offers accurate control of paramount local parameters such as stoichiometry and temperature as well as robustness through automation [2]. On the other hand, computational chemistry provides insights on intrinsic properties, hence saving time and resource-consuming synthetic work [3]. The module learning relies on an upstream computational study that extracts theoretical data determining the pertinence of the reaction into fluidic conditions. Experimental kinetics data are then determined in flow at different temperatures and used for dynamic feedback. [less ▲]

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See detailSurveillance des flux d’azote en zone de captage : Premières avancées du projet RIVE
Scheuren, Marie ULiege; Daigneux, Benjamin; Felten, Valentin et al

Poster (2021, November 24)

L’azote est un des éléments nutritifs les plus utilisé en agriculture. L’impact d’un excès d’azote sur la qualité des eaux est bien connu. Cela provoque notamment la pollution en nitrate des eaux ... [more ▼]

L’azote est un des éléments nutritifs les plus utilisé en agriculture. L’impact d’un excès d’azote sur la qualité des eaux est bien connu. Cela provoque notamment la pollution en nitrate des eaux souterraines. Par ailleurs, lors de l’applicationde ces fertilisants azotés, une quantité non négligeable de l’azote est perdue par volatilisation sous forme d’ammoniac. Ces émissions engendrent des nuisances olfactives et sont également responsables de la formation de particules fines. Ces pollutions peuvent être réduites en améliorant les pratiques culturales et plus particulièrement la fertilisation. Le projet de recherche RIVE (Ruissellement, Infiltration, Volatilisation, Erosion) financé par la SPGE (Société Publique de la Gestion de l'Eau, BE) est basé sur la surveillance d'une prairie permanente entourant une zone de captage dont les concentrations en nitrate sont trop importantes. Ce projet, de deux ans, vise à développer un outil d’aideà la décision concernant les pratiques agricoles dans les zones de captage d’eaude distribution, affectées notamment par l’agriculture. L’ensembledes données récoltées permettra de déterminer un bilan azote complet en zones agricoles et d'adapter les pratiques agricoles afin de réaliser des apports azotés optimaux. [less ▲]

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See detailResolving perceptual rivalry: an ultra-high field 7T fMRI study
Koshmanova, Ekaterina ULiege; Beckers, Elise ULiege; Campbell, Islay ULiege et al

Poster (2021, November 24)

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See detailChirurgie bariatrique et trouble de l’usage de l’alcool : protocole d’une recherche par les méthodes mixtes
Er, Esin ULiege; Etienne, Anne-Marie ULiege

Poster (2021, November 20)

Contexte : l'obésité a atteint des proportions pandémiques à travers le monde. Ce trouble nuit tant à la qualité de vie, à la santé physique et psychologique de ceux qui en souffrent, qu'à l'économie des ... [more ▼]

Contexte : l'obésité a atteint des proportions pandémiques à travers le monde. Ce trouble nuit tant à la qualité de vie, à la santé physique et psychologique de ceux qui en souffrent, qu'à l'économie des pays. La chirurgie bariatrique s'est révélée être une intervention efficace à long terme pour traiter l'obésité et les comorbidités qui y sont associées. Cependant, depuis plus d'une décennie, des recherches soulignent les conséquences négatives que peut engendrer cette intervention sur le plan psychosocial et notamment, au niveau de la consommation d'alcool. Ce poster présente le protocole d’une recherche par les méthodes mixtes (RMM) dont l'objectif est de déterminer les prédicteurs du trouble de l'usage de l'alcool (TUA) post-chirurgie bariatrique. Méthodes : cette RMM suivra un design séquentiel exploratoire constitué de deux phases de recherche. La première phase consistera à explorer, à travers des méthodes qualitatives, les mécanismes psychologiques conduisant certaines personnes à développer un TUA après la chirurgie bariatrique. La méthode de collecte des données employée lors de cette première phase sera l'entretien de recherche. L’analyse phénoménologique interprétative servira à analyser le contenu des entretiens. Cette première phase permettra de formuler des hypothèses sur les prédicteurs et les mécanismes psychologiques sous-jacents au développement d’un TUA postopératoire. La seconde phase visera à tester statistiquement, à travers une étude longitudinale, les hypothèses formulées lors de la première phase de recherche. La collecte de données sera réalisée à travers des questionnaires empiriquement validés et les données feront l’objet d’analyses statistiques descriptives et inférentielles. Intérêt de la recherche : à terme, les résultats de cette recherche permettront d’identifier quelles sont les personnes les plus à risque de développer un TUA après la chirurgie bariatrique. Cela ouvrira la possibilité d’élaborer des programmes de prévention visant à éviter l’apparition de nouveaux cas de TUA postopératoire et de mettre en place une prise en charge plus soutenue et adaptée pour ces patients. [less ▲]

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See detailThyroid ultrasound as a new tool to assess thyroid metabolism in cattle: preliminary results
Eppe, Justine ULiege; Raguet, Elise ULiege; PETROSSIANS, Patrick ULiege et al

Poster (2021, November 19)

Thyroid troubles are poorly documented in cattle. Ultrasonography is a tool used in other species to evaluate thyroid pathologies. The objective of this work is to describe the normal ultrasonographic ... [more ▼]

Thyroid troubles are poorly documented in cattle. Ultrasonography is a tool used in other species to evaluate thyroid pathologies. The objective of this work is to describe the normal ultrasonographic appearance of the thyroid gland in cattle and to validate the reliability of its measurements. In this study, 11 calves and 12 adult cows were enrolled at the University Veterinary Clinic of Liege. A thyroid ultrasonography was realized on each animals using a linear (calves) or convex (cow) probe on two views (transverse and longitudinal), measuring the length (l), width (w) and height (h) of each lobe and the height of the isthmus. Finally, the animals were euthanized and their thyroids were removed for weighing, measuring and histological examination. Volume was measured by liquid displacement, and calculated using two formulas: PI/6*l*w*h; PI/4*l*w*h. The appearance of the thyroid was iso- or hyperechoic to the muscles and homogeneous. The capsule also appeared hyperechoic. Then, although the thyroid measurements are mostly significantly different (p>0.05) from those in post-mortem, the volume measured did not differ significantly (p>0.1) from the volume calculated. Ultrasound did not detect histological abnormalities such as follicular hypo- or hyperplasia. In one cow, a follicular cyst 0.4 cm in diameter was observed. Further studies are needed to validate the ultrasound examination on a larger number of non-debilitated animals. Intra or inter-observer variability could be measured, for example. Additional work is also needed to address other aspects of thyroid metabolism, such as the use of ultrasound Doppler and hormonal blood tests. [less ▲]

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See detailClostridioides difficile virulence genes expression in an insert plate model
Martinez, Elisa ULiege; Doumont, Lara; Taminiau, Bernard ULiege et al

Poster (2021, November 19)

Clostridioides difficile is a Gram positive bacterium sporulant and requires strict anaerobiosis. The intestinal carriage of C. difficile can be asymptomatic, but in cases of infection it is associated ... [more ▼]

Clostridioides difficile is a Gram positive bacterium sporulant and requires strict anaerobiosis. The intestinal carriage of C. difficile can be asymptomatic, but in cases of infection it is associated with different clinical signs of disease that can vary from mild diarrhea to pseudomembranous colitis or even death. Expression of C. difficile virulence gene was studied in an in vitro insert plate model. The objective of this study was to identify the timing of expression of virulence gene of C. difficile. In compartment “in”, a nutritive matrix, salt biles and a quantity of C. difficile spores were placed. In compartment “out”, a nutritive matrix and salt biles were placed. Several plates were made to study a plate without feces, two with a variation of the concentration of spores, two with a variation of the concentration of feces concentration and four with a variation of the microflora. Total DNA and RNA were extracted and RT-qPCR targeting mldA (evolved in cell division), gluD (housekeeping genes), tcdB and tcdA (toxins genes) This method of culture allows the growth of C. difficile under different growth conditions. The plate without feces is the benchmark. The expression of genes varies depending on the growth conditions and some donors (D2 and D4) will promote the production of toxins. Among the donors, donors 4 gives us a pattern that is closer to the expression of the virulence genes of the insert without feces. The next step of our study will use metatranscriptomics to identify the expression of certain genes that have an impact on colonization. [less ▲]

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See detailFrench translation and validation of the Keele STarT MSK Tool
BEAUDART, Charlotte ULiege; Criscenzo, Loredana ULiege; Bornheim, Stephen ULiege et al

Poster (2021, November 19)

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See detailFrench translation and validation of the Identification of Functional Ankle Instability (idFAI) tool
BEAUDART, Charlotte ULiege; Mehmeti, Klejdi ULiege; Van Beveren, Julien et al

Poster (2021, November 19)

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See detailRetifanlimab (INCMGA00012) in Patients With Recurrent MSI-H or dMMR Endometrial Cancer: Results From the POD1UM-101 Study
Berton, Dominique; Pautier, Patricia; Lorusso, Domenica et al

Poster (2021, November 10)

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See detailNewborn Screening for Endocrine Disorders: Belgian Experience with ZenTech s.a. devices
BOULANGER, Madeleine; BOEMER, François ULiege; COENEN, Roland ULiege et al

Poster (2021, November 10)

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See detailThe Irradiation-Induced Renal Ischemic Preconditioning Is Blunted by the Oral Administration of the Anti-Angiogenic Agent Sunitinib
Khbouz, Badr ULiege; LALLEMAND, François ULiege; Rowart, Pascal ULiege et al

Poster (2021, November 04)

Background: Whole-body irradiation has been suggested to induce renal ischemic preconditioning(RIP) in mice, possibly via angiogenesis. First, we comprehensively investigate the pathways involved in renal ... [more ▼]

Background: Whole-body irradiation has been suggested to induce renal ischemic preconditioning(RIP) in mice, possibly via angiogenesis. First, we comprehensively investigate the pathways involved in renal irradiation. Next, we assess the functional impact of renal irradiation applied before renal ischemia/reperfusion(I/R) injury. Finally, we test whether Sunitinib-mediated inhibition of the angiogenesis prevents irradiation-associated RIP. Methods: Exp1: Renal irradiation(8.56 Gy) was performed in male C57bl/6 mice(n=10). One month later, total kidney RNA was extracted from irradiated and control(n=5) mice for comparative RNA-Seq. Exp2: After renal irradiation, the right kidneys were removed, and the left kidneys undergo ischemia(30min)/reperfusion(48h) at Days 7-14-28 post irradiation(n=8). Exp3: Following the same protocol of I/R at Day14, 3 groups were compared(n=8): 1/irradiation; 2/irradiation and gavage with Sunitinib from Day2 to 13; 3/control group without irradiation or gavage. Results: Exp1: RNAseq showen up-regulation of angiogenesis signalling pathways. Expressions of angiogenesis markers(CD31, VEGF) showed an increase at both mRNA and protein levels in irradiated kidneys(p<0.01). Exp2: Following I/R, Blood Urea Nitrogen(BUN) and Creatinine(SCr) levels were lower in the irradiated mice compared to controls: (BUN: 86.2±6.8 vs. 454.5±27.2mg/dl; SCr: 0.1±0.01 vs. 1.7±0.2mg/dl, p<0.01). The renal infiltration by CD11b-(187±32 vs 477±20/mm2) and F4-80-positive cells(110±22 vs 212±25/mm2) was reduced in the irradiated group. VEGF and CD31 expression was increased in irradiated kidneys at both mRNA and protein levels(p<0,01). Exp3: One-way analysis of variance followed by Tukey’s test showed that, following I/R, BUN and SCr levels were lower in the irradiated group compared to controls(BUN: 106.1±33.6 vs. 352.2±54.3mg/dl; SCr: 0.3±0.13 vs. 1±0.2mg/dl), and in irradiated group compared to the irradiated-exposed group to Sunitinib(BUN: 106.1±33.6 vs. 408.4±54.9mg/dl; SCr: 0.3±0.12 vs. 1.5±0.3mg/dl; p<0.01). Conclusion: Renal irradiation induces the activation of angiogenesis in mice. Renal irradiation leads to RIP, with preserved renal function and attenuated inflammation post I/R. Exposure to the anti-angiogenic drug Sunitinib post-irradiation prevents the irradiation-induced RIP. [less ▲]

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See detailImpact of being immersed in an elderly patient’s shoes confronted to non empathic ageist attitudes on ageism and empathy Comparison of two methods: Immersive 360 videos and 2D computer screen
Goosse, Manon ULiege; Willems, Sylvie ULiege

Poster (2021, November 03)

Lack of empathy and negative stereotypes, such as ageism, are two important barriers for an effective patient/clinician relationship (Elliott, et al. 2018; Schroyen et al., 2018). Some techniques have ... [more ▼]

Lack of empathy and negative stereotypes, such as ageism, are two important barriers for an effective patient/clinician relationship (Elliott, et al. 2018; Schroyen et al., 2018). Some techniques have been developed to reduce negative perceptions of ageing and favor empathy such as taking the perspective of an older person through more or less immersive tools and have shown encouraging results (e.g. game; virtual reality) (Adefila, et al. 2016; Pacala et al. 2006). The aim of this study is to evaluate the impact of a 360° immersive video that immerses the participant in the shoes of an elderly patient confronted with (1) a non-ageist empathic clinician and (2) a non-ageist empathic clinician during a psychological interview. We hypothesized that, confronted through these immersions, participants will identify negative impacts of ageist attitudes, which may help to increase empathy and reduce ageism. A control group watched the same videos on a 2D computer screen. Fifty psychological students were randomized to one of the two conditions. Before and after immersion, participants had to complete questionnaires assessing empathy and ageism. Results shows a positive effect of time in both conditions on empathy (JSE1 (Hojat et al., 2002) ; p<.001; n²=0.959) and a decrease of hostile ambivalent ageism (AAS (Cary et al. 2017) ; p<.003; n²=0.021) (See table 1 and figure 1). No condition effects were revealed, which should question the additional benefit of immersive videos in this context. However, as most of results lack of power, further studies should replicate this study to confirm this result. [less ▲]

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See detailMONTE CARLO FORECAST FOR 241AM/BE DSRS MANAGEMENT OPTIMIZATION IN CAMEROON
Guembou Shouop, Cébastien Joel ULiege; Beyala Ateba, Jean Felix; Simo, Augustin

Poster (2021, November)

The present research provided an optimal option for Disused Sealed Radioactive Sources (DSRS) management based on Monte Carlo simulation. The objective was to design the appropriate means for radioactive ... [more ▼]

The present research provided an optimal option for Disused Sealed Radioactive Sources (DSRS) management based on Monte Carlo simulation. The objective was to design the appropriate means for radioactive waste conditioning to avoid material and economic losses based on trials during the sources' dismantling and to find the best optimizing DSRS geometry package. The Particle and Heavy Ion Transport code System (PHITS) was used to design waste containers with appropriate DSRS to get the ALARA principle of dose limitation in the boundary of the waste package. The investigated radioactive waste was made of several disused 241Am/Be neutron sources previously used in well-logging and petroleum exploration in the Gulf of Guinea (CAMEROON). From the obtained result, disk and cylinder were found to be the most appropriate geometries while the parallelepiped geometry was the worst case. The obtained results were stored for the upcoming IAEA expert mission to dismantle and store the DSRS in Cameroon. [less ▲]

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See detailConsensus on the content of an educational program for patients with oropharyngeal dysphagia and their informal caregivers: A Delphi Study
GHADDAR, Zahya; MATAR, Nayla; TOHME, Aline et al

Poster (2021, November)

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See detailStudy of operational parameters on the desorption/ionization and fragmentation of benzylpyridinium ions using gold-capped silicon nanopillars in SALDI-MS
Müller, Wendy ULiege; Far, Johann ULiege; De Pauw, Edwin ULiege et al

Poster (2021, November)

Introduction The use of nanostructured substrates as assisting materials in surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) has gained increasing attention, especially for ... [more ▼]

Introduction The use of nanostructured substrates as assisting materials in surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) has gained increasing attention, especially for analyzing small molecules. Indeed, nanosubstrates usually led to an increased signal reproducibility and a cleaner chemical background in the low m/z range compared to MALDI matrices. However, the understanding of the SALDI process remains incomplete. The impact of the operational parameters on the analyte desorption/ionization (D/I) and fragmentation is of crucial importance in fundamental research and analytical applications. In this study, the survival yield (SY) and D/I of benzylpyridinium (BP) “thermometer” ions were determined during SALDI-MS experiments using a novel nanosubstrate composed of gold-capped silicon nanopillars as a function of several operational parameters. Method Mass spectra of benzylpyridinium ions (p-CH3-BP, 10-4 M in water/acetonitrile 1:1) were acquired between m/z 40 and 260 in reflectron positive ionization mode using a Bruker RapifleX mass spectrometer equipped with a 355-nm SmartBeam3D laser. The influence of several parameters, such as the laser power, footprint and pulse frequency, the number of laser shots, and the duration of the pulsed delay extraction was evaluated. The desorption/ionization (D/I) and survival yields (SY) were calculated for all mass spectra. The D/I is the summation of the intensity of the parent and fragment BP ions. D/I=I_Parent+I_Fragment The SY were determined from the relative intensities of the parent and fragment ions. SY=I_Parent/(I_Parent+I_Fragment ) Preliminary data Gold-capped silicon nanopillar arrays, which are originally designed for Surface-Enhanced Raman Spectroscopy, were tested in SALDI-MS in the perspective of further multimodal analyses. The D/I and SY of BP thermometer ions, and the influence of the operational parameters were studied using these nanosubstrates as assisting materials. In addition to the laser power whose impact has been widely studied using different types of substrates, several other parameters have been tested here: the laser footprint, the laser pulse frequency, the number of laser shots, and the duration of the pulsed delay extraction. Our study suggests that the laser footprint and the pulsed delay extraction have a significant impact both on the D/I and the SY of BP ions, while the number of accumulated laser shots only has an impact on the D/I. On the contrary, the laser shot frequency does not seem to have an impact neither on the D/I nor on the SY. The integrity of the nanosubstrate after the SALDI-MS analyses was also investigated by scanning electron microscopy. This study enables to better understand the fundamental processes underlying SALDI, and to determine the optimal conditions for efficient desorption/ionization of either the BP parent or the fragment by controlling the fragmentation and the nanosubstrate destruction. Indeed, the degradation of the nanosubstrate leads to the formation of interferent ions in the low m/z range. Besides this physicochemical part of the study, the analytical performance of the nanosubstrates was also evaluated. We demonstrated that under optimal conditions no interferent ion was produced alongside the analyte ions in the studied m/z range. On the contrary, the mass spectra acquired with MALDI matrices and gold nanoparticles (AuNPs) were characterized by more background peaks. The nanosubstrates also offer better reproducibility of the signal intensity compared to CHCA and AuNPs, which opens the way for quantification studies. Novel aspects Evaluation of the analytical performance of a SERS nanosubstrate in SALDI-MS and study of the influence of the operational parameters. [less ▲]

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See detailProbing the Mechanochemical Properties of a Small Synthetic Knot by AFM
Sluysmans, Damien ULiege; Song, Yiwei; Zhang, Liang et al

Poster (2021, November)

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See detailEffect of switches in brain states on calcium-based plasticity rules: a computational study for sleep-dependent memory consolidation.
Jacquerie, Kathleen ULiege; Minne, Caroline ULiege; Drion, Guillaume ULiege

Poster (2021, November)

Sleep contributes to memory through a mechanism called sleep-dependent memory consolidation. Little is known about its underlying physiological and functional mechanisms, but it involves global and long ... [more ▼]

Sleep contributes to memory through a mechanism called sleep-dependent memory consolidation. Little is known about its underlying physiological and functional mechanisms, but it involves global and long-lasting switches in neuronal population activity, called the wake-sleep pattern. At the network level, neuronal populations show transitions from active states to oscillatory states. Zooming in at the cellular level, neurons switch from tonic firing to bursting. In parallel, memory and learning rely on functional changes in neuronal connectivity through a process called synaptic plasticity. The main goal of this project is to investigate how these transient switches in brain rhythmic activity, or brain states, affect synaptic plasticity and learning. To this end, we exploit recent advances in the mathematical modeling of cellular-induced fast and localized switches in brain states [Drion, 2018; Jacquerie, 2021]. These models make the generation of brain state switches independent from synaptic weights between neurons and thus compatible with synaptic plasticity. We investigate the interaction between switches in brain states and learning using an associative memory task, which quantifies the ability of neurons coding for concomitant events to strongly connect together. To do so, we embed a neuron conductance-based model with a calcium-dependent plasticity rule in which internal calcium concentration governs the direction and the amplitude of the synaptic changes [Shouval, 2002; Graupner and Brunel, 2016], where internal calcium dynamics are regulated by the activation of NMDA receptors and voltage-gated calcium channels. This rule is parametrized to fit experimental data guaranteeing the correct behavior in wake state [Sjostrom, 2001]. The synaptic plasticity rule is shown to fail to reproduce sleep-dependent memory consolidation theories such as synaptic homeostasis hypothesis [Tononi,2020] or active system consolidation [Born, 2012] for any parameter values. Indeed, regardless of the connection strengths established during the day, they all converge to a fixe point during the night, which resets the circuit connectivity during sleep without showing any down-selection or reinforcement. Adding the effect of neuromodulators on calcium-dependent plasticity rule solves this problem by modifying calcium signal transduction pathways, hence the synaptic rule properties. The proposed model makes it therefore possible to track the evolution of synaptic wiring during sleep-wake switches, as well as to study sleep related mechanisms that can affect plasticity rules. [less ▲]

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See detailFOOD CONTAMINATION WITH MINERAL OILS DETERMINED BY GC×GC-TOFMS/FID
Selecky, T; Losa, S; Panto, Sebastiano et al

Poster (2021, October 21)

Mineral oil hydrocarbons (MOHs) derives from crude petroleum through distillation processes and various refining steps. It contains saturated hydrocarbons (MOSH) and aromatic hydrocarbons (MOAH). MOHs as ... [more ▼]

Mineral oil hydrocarbons (MOHs) derives from crude petroleum through distillation processes and various refining steps. It contains saturated hydrocarbons (MOSH) and aromatic hydrocarbons (MOAH). MOHs as food contaminant has received attention due to its possible negative effects on human health [1], as stressed in the Opinion published in 2012 by the European Food Safety Authority (EFSA) (Panel on Contaminants in the Food Chain), pinpointing particularly towards MOAH with three or more, non- or simple alkylated aromatic rings as the main potential concern” [2]. The routine analytical method to determine the amount of MOHs in food uses hyphenated high-performance liquid chromatography - gas chromatography with a flame ionization detector (HPLC-GC/FID) [3]. A disadvantage of this method is that it gives no conclusive information about the type of substances present in the contamination and does not enable the separation of either different MOAH sub-classes or MOSH from MOSH- Analogs. Comprehensive two-dimensional GC combined with time-of-flight mass spectrometry (GC×GC-TOFMS) allows a separation of the different sub-classes, nevertheless the MS cannot provide any quantitative information. Therefore, parallel detection in combination with an FID detector, has been developed for the characterization and quantification of MOHs in food. However, to be able to translate the information acquired by the TOFMS detector to the quantification process in FID, a fine tune of the chromatographic conditions is needed in order to obtain comparable 2D plots to compensate the different outlet pressure (vacuum for MS and atmospheric pressure for FID). At the same time, a suitable software for quantification of selected regions in the FID contour plot is being developed, showing promising preliminary results [4]. References: [1] Hochegger A. & Moret S., Geurts L., Gude T., Leitner E., Mertens B., O’Hagan S.,Poças F., Simat J. T. and Purcaro G., Mineral Oil Risk Assessment: Knowledge Gaps and Roadmap. Outcome of a multi-stakeholders workshop, Trends Food Sci & Technol, 113, 2021, 151-166 [2] European Food Safety Authority (EFSA), 2012, Scientific Opinion on Mineral Oil Hydrocarbons in Food, EFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Journal 10(6), 2704 [3] Biedermann M, Grob K, 2012, On-line coupled high performance liquid chromatography–gas chromatography for the analysis of contamination by mineral oil. Part 1: Method of analysis, Journal of Chromatography A, Volume 1255, 2012, Pages 56-75. [4] Bauwens G. Pantò S., Purcaro G., MOSH and MOAH quantification: mono- and two-dimensional approaches Journal of Chromatography A, 2021, 1643, 462044 [less ▲]

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See detailMICROWAVE ASSISTED SAPONIFICATION FOLLOW BY LC-GC-FID AND LC-GC × GC TOFMS/FID FOR MOSH AND MOAH DETERMINATION IN DIFFERENT DRY SAMPLES
Bauwens, Grégory ULiege; Purcaro, Giorgia ULiege

Poster (2021, October 21)

Mineral oil hydrocarbons in food is a hot topic under intense investigation in the last decade. A high throughput, high-sensitivity procedure, involving simultaneous microwave assisted saponification and ... [more ▼]

Mineral oil hydrocarbons in food is a hot topic under intense investigation in the last decade. A high throughput, high-sensitivity procedure, involving simultaneous microwave assisted saponification and extraction (MAS), followed by on-line liquid chromatography (LC)–comprehensive multidimensional gas chromatography (GC×GC) with parallel detection, time-of-flight (ToF) mass spectrometry (MS) and flame ionization detector (FID) is proposed. MAS has the advantage of assuring rapid and efficient simultaneous enrichment and extraction step of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) in dry foods. The use of a fully integrated LC- GC×GC-ToFMS/FID platform allows to improve the sample throughput, minimizing sample manipulation. Moreover, the use of a novel 2D software allows to perform simultaneously quantification by FID and confirmation thanks to the increased separation and the highly informative two-dimensional plot obtaining using GC×GC coupled to ToFMS [1]. Acknowledgement This work is supported by Fonds de la Recherche Scientifique Belgique (FNRS) (CDR projects MOHPlatform, J.0170.20). The authors thank Milestone, LECO and Restek for their support. References: [1] Bauwens et al., J. Chromatography A, Volume 1643, 2021, 462044 [less ▲]

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See detailAssessment of kernel presence in winter wheat ears using Near-Infrared Hyperspectral Imaging
Vincke, Damien ULiege; Mercatoris, Benoît ULiege; Eylenbosch, Damien et al

Poster (2021, October 18)

Obtaining varieties with higher yield is one of the aims of crop breeding. For winter wheat (Triticum aestivum L.), yield is the result of three components which are the number of ears per unit area, the ... [more ▼]

Obtaining varieties with higher yield is one of the aims of crop breeding. For winter wheat (Triticum aestivum L.), yield is the result of three components which are the number of ears per unit area, the number of kernels per ear and the kernel weight. The occurrence of stresses during crop growth can have a negative impact on the yield components. For example, abiotic stresses such as drought or frost, if they occur at sensitive stages of the crop can cause a decrease in the number of kernels per ear. On the other hand, biotic stresses induced by a disease such as Fusarium Head Blight (FHB) can also cause a decrease in the number and weight of kernels per ear. Assessing the physiology behind the number of kernels and the impact of stresses is a complex process requiring observations at specific critical periods of the crop cycle. The scope of this study is to propose an innovative method based on Near Infrared Hyperspectral Imaging (NIR-HSI) to evaluate the presence of kernels in winter wheat ears. This preliminary study allowed the evaluation of the potential of the method using winter wheat ears collected in a field trial in Belgium. NIR-HSI combined with chemometric tools identified spectral bands potentially characteristic of the presence of kernels inside the ears. A chemometric model using Partial Least Squares Discriminant Analysis (PLS-DA) enabled the identification of ears with and without kernels. The PLS-DA results allowed tracking the presence of kernels in winter wheat ears at spikelet level. These results indicate that NIR-HSI might be a useful method to provide information assessing the status of kernels inside the ear, which plays an important role in yield assessment. [less ▲]

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See detailStudy of the ciliary function in adult and pediatric patients with cystic fibrosis
Bricmont, Noémie ULiege; Bonhiver, Romane ULiege; Benchimol, Lionel ULiege et al

Poster (2021, October 15)

Background: Mucociliary clearance(MCC) results in an effective interaction between the mucus layer and the normal coordinated ciliary beating. In cystic fibrosis(CF), MCC is impaired due to dehydrated ... [more ▼]

Background: Mucociliary clearance(MCC) results in an effective interaction between the mucus layer and the normal coordinated ciliary beating. In cystic fibrosis(CF), MCC is impaired due to dehydrated mucus, but ciliary function is poorly studied. Recent data suggested that abnormal ciliary beating may contribute to poor MCC in CF patients. However, results are controversial: ciliary beat frequency(CBF) might be either decreased or increased, compared with healthy subjects. We aimed to evaluate if ciliary function may have a role in impaired mucociliary clearance in CF patients and if this ciliary dyskinesia was present in childhood. Methodology: Ciliated epithelial samples were obtained by nasal brushing from 22 pediatric (0-17 years) and 15 adult CF patients (18-78 years). Beating cilia were recorded using digital high-speed videomicroscopy at 37°C. Ciliary functional analysis(CFA) was assessed by CBF and the percentage of abnormal ciliary beat pattern(CBP) and was compared with 14 healthy subjects(HS) (22-54 years). Results: There was a significant difference in CBF only between adult CF patients and HS. Abnormal CBP was significantly higher in CF patients, regardless of the age of patients. Conclusion: This study suggested that an abnormal ciliary function, present in childhood, might contribute to impaired MCC in CF patients as shown by lower CBF or higher dyskinetic CBP compared with HS. To evaluate if ciliary dyskinesia is primary or secondary to chronic inflammation, CFA should be repeated after air-liquid interface cell culture. [less ▲]

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See detailEnquête sur le partenariat de soins auprès de patients et de professionnels de santé– Validation psychométrique d’outils de mesure
Nguyen-Thi, Phi-Linh; Voyen, Madeline; Bohme, Philip ULiege et al

Poster (2021, October 15)

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See detailImproving Schlieren methods for measuring interface topography
Metzmacher, Jean ULiege; Lagubeau, Guillaume; Poty, Martin ULiege et al

Poster (2021, October 11)

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See detailAnalyse du processus de mise en œuvre des logiciels d’e-GRH au sein des établissements d’enseignement supérieur en RDC
Limeka Li-Mabila, Limex ULiege; Cornet, Annie ULiege

Poster (2021, October 08)

Purpose - The purpose of this communication is to systematically understand how electronic human resource management (e-HRM) software for personnel management is implemented in the particular context of ... [more ▼]

Purpose - The purpose of this communication is to systematically understand how electronic human resource management (e-HRM) software for personnel management is implemented in the particular context of higher education institutions (HEIs) in the Democratic Republic of Congo (DRC). Methodology/approach - The posture of a symbolic interactionist perspective guided our understanding in a qualitative case study methodology as it concerns the clarification of the implementation process of e-HRM software for personnel management in this specific context. Results - In terms of results, the context of HIEs in the DRC was described and the business processes were modeled, thus presenting the way in which personal data is encoded in HIEs in the DRC. Limitations - Several limitations can be noted, but as an example, the complexity of the research environment with respect to research authorizations. Implications - This paper sheds light on the managerial and scientific aspects and its contribution to the understanding of the critical and complex process of the implementation of e-HRM software in the context of HEIs in the DRC. Originality – Except for the BPMN language used, the originality of this paper resides in the particular context of HEIs in the DRC, as well as in the integration of implementation conditions in their social-technical-financial components, in light of Pichault's (2013) five forces model. [less ▲]

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See detailA circularity evaluation framework for office buildings design in Belgium
Al-Obaidy, Muheeb ULiege

Poster (2021, October 07)

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See detailProsocial and Aggressive driving behaviours and driving-related outcomes in Vietnam
Bui Trung Hiep, ULiege

Poster (2021, October 07)

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See detailNew production technologies and high-performance materials
Saufnay, Loris ULiege

Poster (2021, October 07)

By contrast with the conveyed image, the construction sector regularly evolves with a constant concern for quality, safety and, of course, for economic efficiency. As a matter of fact, steelmakers are ... [more ▼]

By contrast with the conveyed image, the construction sector regularly evolves with a constant concern for quality, safety and, of course, for economic efficiency. As a matter of fact, steelmakers are, nowadays, able to produce more resistant steels through more efficient processes. In recent years, the research interest is focused on two aspects which are: the impact of new production processes on member stability and the economic benefit in using high strength steel in steel structures. [less ▲]

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See detailLes trajectoires professionnelles des femmes avec diplôme universitaire en République Démocratique du Congo au travers des récits de vie de femmes de trois générations (moins de 30 ans, 30 a 40 ans, plus de 40 ans)
Kitenge Maningo, Sara ULiege

Poster (2021, October 07)

Cet article vise à décrire les trajectoires professionnelles des femmes avec diplôme universitaire en République Démocratique du Congo au travers des récits de vie de femmes de trois générations (moins de ... [more ▼]

Cet article vise à décrire les trajectoires professionnelles des femmes avec diplôme universitaire en République Démocratique du Congo au travers des récits de vie de femmes de trois générations (moins de 30 ans, 30 à 40 ans, plus de 40 ans), identifier les causes individuelles, organisationnelles, et sociétales de leurs choix, réorientations et changement, les succès, mais aussi les difficultés, les échecs, et les frustrations qu’elles connaissent dans leurs parcours professionnels, ainsi proposer des plans d’actions pour l’amélioration de l’égalité entre les hommes et les femmes en RDC. Notre positionnement épistémologique étant constructiviste, nous cherchons à voir qu’elle est la perception que les femmes ont de leurs parcours professionnel. C’est ainsi que nous avons jugé intéressant de recourir à l’approche qualitative, pour collecter les récits de vie de ces femmes et faire une analyse thématique de ce qu’elles nous ont raconté sur leur vécu professionnel, c’est elles qui vont isoler les éléments qu’elles jugent importants et qui ont influencé leurs trajectoires professionnelles. [less ▲]

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See detailMethodology for the evaluation of Indoor Quality and comfort in schools’ classrooms
Diaz Cisternas, Muriel Andrea ULiege

Poster (2021, October 07)

Research on Indoor Environmental Quality in schools usually refers to one or two aspects of the four (thermal, acoustic, visual and air quality), even the most recent research deals with these topics ... [more ▼]

Research on Indoor Environmental Quality in schools usually refers to one or two aspects of the four (thermal, acoustic, visual and air quality), even the most recent research deals with these topics separately without considering all the factors that influence the environmental quality of the spaces. This research proposes a methodology to evaluate the indoor conditions in classrooms through surveys and measurements and presents a first approximation to an index to evaluate IEQ in an integrated way. [less ▲]

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See detailSources of contamination of raw milk butter with Escherichia coli during processing
Barbosa, Naomi ULiege; Gerard, Amaury ULiege; Di Tanna, Sybille ULiege et al

Poster (2021, October 07)

Introduction In Wallonia, raw milk butter manufacture is frequenta. A hygienic indicator for this process is E. coli, with criteria established by Regulation (EC) No 2073/2005b. Five samples of butter are ... [more ▼]

Introduction In Wallonia, raw milk butter manufacture is frequenta. A hygienic indicator for this process is E. coli, with criteria established by Regulation (EC) No 2073/2005b. Five samples of butter are considered at the end of manufacture. If levels of E. coli are < 10 cfu/g, batch is considered as satisfying. If a maximum of two samples have levels between 10 and 100 cfu/g, batch is acceptable. In other circumstances, batch is unsatisfactory. This study aimed at monitoring butter manufacture in dairy farms facing recurrent spoilage by E. coli to identify key steps responsible for this contamination. Materials and Methods Six Walloon farms were considered, and visited three times each. Surface samples were collected using Petrifilm Rapid E. coli/coliforms or swabs, in triplicates, including pipes before and after cream separator, cream separator itself, containers for cream maturation and churn. Intermediate and end products were also considered, in five replicates, namely whole raw milk, skimmed milk, ripened cream and butter. Product samples were diluted 10-fold in Buffered Peptone Water and spread on Petrifilm. All Petrifilms were incubated at 30 °C for 18 to 24 h. Statistical treatments were performed using Minitab19. Correlations between two variables were considered using linear regression. Effect of factors on milk quality was assessed using one-way ANOVA. Discussion Globally, out of 18 butter batches, 14 (78%) were unsatisfactory, but generally with levels < 3 log10 cfu/g. Identified critical points of contamination included whole milk supply pipe and milk inlet to cream separator. Milking equipment impacted significantly milk quality; milking robots being associated with recurrent contaminations of intermediate and end products. Frequent and effective disinfection practices must be recommended. Producers should also limit time lapse between milking and cooling. As last resort, starters could be added to cream for faster and more intense maturation. [less ▲]

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See detailOverheating Indicator and Calculation Method for Walloon Buildings
Amaripadath, Deepak ULiege

Poster (2021, October 07)

Overheating in buildings is expected to be more intense and prolonged due to the current rate of climate change and global warming. There is a significant need for resilient building design and therefore ... [more ▼]

Overheating in buildings is expected to be more intense and prolonged due to the current rate of climate change and global warming. There is a significant need for resilient building design and therefore it is mandatory to develop calculation methods and indicators to avoid overheating and invest in carbon neutral cooling technologies and sustainable solutions. There is still a challenge of keeping the occupants safe, comfortable, and productive in an affordable way despite the rising temperatures and changes in the rainfall and solar irradiance. [less ▲]

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See detailDo you want to analyze floating structures much faster?
Geuzaine, Margaux ULiege; Denoël, Vincent ULiege

Poster (2021, October 07)

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See detailEtude technique et proposition de solutions de réparation des maisons métalliques du Kongo-Central en vue de leur reconversion et de leur patrimonialisation
Mpemba Nkole Kabongo, Aris ULiege; Demonceau, Jean-François ULiege; Jaspart, Jean-Pierre ULiege

Poster (2021, October 07)

Conçues en Belgique et construites en RDC au début de la colonisation, les maisons à ossatures métalliques du Kongo-Central, en RDC, présentent un état d’endommagement avancé lié non seulement aux ... [more ▼]

Conçues en Belgique et construites en RDC au début de la colonisation, les maisons à ossatures métalliques du Kongo-Central, en RDC, présentent un état d’endommagement avancé lié non seulement aux conditions climatiques de la zone, mais aussi à celles d’exploitation par leurs usagers. Une étude approfondie, de ces maisons, est indispensable en vue du développement ultérieur de solutions permettant de les conserver comme patrimoines bâtis de la RDC. [less ▲]

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See detailDevelopment and validation of an LC-UV method for the simultaneous analyses of ciprofloxacin and metronidazole in tablet dosage forms: routine application and confirmation of falsifications
Waffo Tchounga, Christelle Ange ULiege; Sacre, Pierre-Yves ULiege; Ciza Hamuli, Patient ULiege et al

Poster (2021, October 05)

Poor quality medicines pose a threat to all health systems. It is obvious that they have harmful consequences not only from the public health point of view, but also from the economic and socio-economic ... [more ▼]

Poor quality medicines pose a threat to all health systems. It is obvious that they have harmful consequences not only from the public health point of view, but also from the economic and socio-economic as well [1]. In order to effectively combat this scourge, it is important to determine the quality of these medicines circulating on the pharmaceutical market. In general, this quality control is possible thanks to the methods listed in the pharmacopoeias. However, these methods are generally costly, not environmental friendly and often not easy to implement [2]. In this context and to overcome these disadvantages we undertook the development and validation of a rapid, less polluting and easy to implement HPLC/DAD method for the simultaneous analyses of two anti-infective very used and targeted by falsifiers, ciprofloxacin and metronidazole. Retention times of 1.7min and 3.4min were obtained for metronidazole and ciprofloxacin respectively, using a mobile phase consisting of 0.025M orthophosphoric acid adjusted to pH3 with Triethylamin and Methanol (75:25) (v/v), an XBridge column C18 (2.1*100mm) 3.5µm and a flow rate of 0.3mL/min. At first, this method was successfully validated to confirm its suitability following the total error approach with the accuracy profile as a decision tool in the laboratory of analytical pharmaceutical chemistry (LCAP) of the University of Liège and then transferred to the Laboratoire National de Contrôle des Médicaments et Expertise (LANACOME) in Cameroon to implement its usability. The acceptation limits were set at +/- 10% in total relative error and the tolerance intervals were built with a risk set at 5%. The routine application of this method allowed the identification and quantification of ciprofloxacin and metronidazole in 96 samples collected in the framework of a prevalence study in Cameroon. On the other hand, it was used as a confirmatory method to identify and quantify metronidazole that has been previously detected in tablets by handheld vibrational spectroscopy methods in 4 falsified chloroquine samples seized on the Cameroonian market during the Covid-19 pandemic. [less ▲]

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See detailBelgian cyanobacterial blooms during the summer of 2019
Van Hassel, Wannes ULiege; Andjelkovic, Mirjana; Durieu, Benoit ULiege et al

Poster (2021, October)

The B-blooms 2 project showed the incidence of (toxic) cyanobacterial blooms in Belgium more than a decade ago1. However, this was the last major monitoring project since then. In response, Flemish and ... [more ▼]

The B-blooms 2 project showed the incidence of (toxic) cyanobacterial blooms in Belgium more than a decade ago1. However, this was the last major monitoring project since then. In response, Flemish and Walloon regional governments started monitoring programs for toxic cyanobacteria blooms in recreational lakes and ponds used for water contact activities (excluding fishing). The current information about bloom occurrence is fragmented, and monitoring practices differ between the regional authorities. Authorities in Brussels did not initiate monitoring program was. Ten years later, blooms are becoming more common in the temporal regions of Europe, and current monitoring programs might not be sufficient to ensure public health safety. Therefore, Sciensano collaborated with the regional authorities reexamine bloom samples from the summer of 2019 based on toxin content and species present in the bloom. In total, we analyzed 78 samples from 23 different ponds and lakes and other surface waters. We used LC-MS/MS to detect and quantify eight microcystin congeners and nodularin and used PCR and sanger sequencing for species determination. In addition, we examined the presence of the mcyE-gene using PCR. After analysis, we found MCs at concentrations between 0.45 µg/l to 683 µg/l and detected mcyE in 42 samples. MC-RR, MC-LR and MC-LY were most commonly detected. Microcystis was the abundant species, although others were also detected. Acknowledgement: Bocquet R. IBGE-BIM Pelikaen J. VMM Burlion N. ISSeP Augem A. Port-Brussel References: 1. Descy, J.-P. et al. Final Report: Cyanobacterial Blooms: Toxicity, Diversity, Modelling and Management. Belg. Sci. Policy SD/TE/01, 84 (2011). [less ▲]

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See detailDeciphering the role of the GPR101 orphan receptor in growth hormone hypersecretion
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine et al

Poster (2021, October)

Growth hormone (GH) is a key modulator of growth and GH over-secretion can lead to gigantism. One form is X-linked acrogigantism (X-LAG), in which infants develop GH secreting pituitary tumors over ... [more ▼]

Growth hormone (GH) is a key modulator of growth and GH over-secretion can lead to gigantism. One form is X-linked acrogigantism (X-LAG), in which infants develop GH secreting pituitary tumors over-expressing the orphan G-protein coupled receptor, GPR101(Trivellin et al, 2014). The role of GPR101 in GH secretion remains obscure. We studied GPR101 signaling pathways and their effects in HEK293 and rat pituitary GH3 cell lines, human tumors and in transgenic mice with elevated somatotrope Gpr101 expression driven by the rat Ghrhr promoter (GhrhrGpr101). We reported that Gpr101 causes elevated GH/prolactin secretion in transgenic GhrhrGpr101 mice but without hyperplasia/tumorigenesis (Abboud et al, 2020). Furthermore, we showed that GPR101 constitutively activates not only Gs, but also Gq/11 and G12/13, which leads to GH secretion but not proliferation. These signatures of GPR101 signaling, notably PKC activation, are also present in human pituitary tumors with high GPR101 expression. These results underline a role for GPR101 in the regulation of somatotrope axis function. [less ▲]

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See detailLocal Mesenchymal Stem Cells injection in Crohn’s disease strictures: a phase I-II, open-label clinical study
VIEUJEAN, Sophie ULiege; LOLY, Jean-Philippe ULiege; BOUTAFFALA, Layla ULiege et al

Poster (2021, October)

Intestinal fibrosis is a common complication of Crohn's disease (CD) leading to progressive bowel stricture formation. Mesenchymal stem cells (MSCs), known for their immunomodulatory, anti-inflammatory ... [more ▼]

Intestinal fibrosis is a common complication of Crohn's disease (CD) leading to progressive bowel stricture formation. Mesenchymal stem cells (MSCs), known for their immunomodulatory, anti-inflammatory and anti-fibrotic properties, could be a potential therapy in this frequently fibro-inflammatory condition. In this phase I–II open-label pilot trial, we aimed to assess safety and efficacy of local MSCs injection in CD strictures. CD patients with a short (less than 5 cm in lengh) non-passable stricture, accessible by ileocolonoscopy, but without intestinal obstruction, fistulas, or abscess, were included. A total of 3X107 allogenic bone-marrow derived MSCs were equally injected in the 4 quadrants of the strictured bowel wall during an ileocolonoscopy. Adverse events and clinical scores (Crohn Disease Activity Index, Short Health Scale and Crohn Disease Obstructive Score) were evaluated at each follow-up visit (at week (W) 4, 12, 24 and 48) while endoscopy and magnetic resonance enterography (MRE) were performed at baseline, W12 and W48. The main judgement criteria for efficacy was the complete (defined by the ability to pass the ileocolonoscope) or partial (defined by a diameter increase) resolution of the stricture at 12 weeks. Second efficacy criteria included complete or partial resolution of the stricture at 48 weeks as well as the evolution of clinical scores at W12 and W48. Between 2018 and 2020, we performed 11 local MSCs injections in 10 CD patients (6 females; aged to 38-65 years; median 45 years old; 70% were smoker). The strictures’ (3 primary, 7 anastomotic; 1 stricture injected twice) location was as follows: 7 at an ileo-colonic or ileo-rectal anastomosis, 1 colonic and 2 of the ileocecal valve. No patient developed abscess or fistula in the follow-up. One patient had actually a small intestinal fistula at baseline (not diagnosed by the routine imaging report but disclosed by the central reading) which remained stable. A total of 5 hospitalizations for occlusion were reported (2 secondary to a different stricture than the injected one) leading to a surgical resection for one patient and an endoscopic dilatation for another one. At 12 weeks, 5 patients (45%) presented a stricture improvement with a complete resolution for 2 and a partial resolution for 3. Of the 11 MSCs injections, 6 strictures were re-evaluated at week 48 (2 patients still undergoing follow-up, 1 operated, 1 dilated, and 1 lost to follow-up), 4 patients had a complete resolution. The evolution of clinical scores between weeks 0, 12 and 48 was not statistically significant and MSCs injection did not significantly modify the stricture characteristics analysed by MRE, except the disappearance of T2 submucosal oedema in two endoscopic responders. Local MSCs injection in non-passable CD stricture was well tolerated over the short term although several occlusions occured in the follow-up indicating insufficient therapeutic effect in thoses cases. Combining the effects of MSCs with the proven effect of endoscopic balloon dilatation could possibly improve the outcome of CD stricture. [less ▲]

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See detailLeveraging historical data for covariate adjustment in the analysis of randomized clinical trials
Branders, Samuel; Pereira, Alvaro; Bernard, Guillaume et al

Poster (2021, October)

The amount of data collected from patients involved in clinical trials is continuously growing. All baseline patient characteristics are potential covariates that could be used to improve clinical trial ... [more ▼]

The amount of data collected from patients involved in clinical trials is continuously growing. All baseline patient characteristics are potential covariates that could be used to improve clinical trial analysis and power. However, the limited number of patients in phases I and II studies restricts the possible number of covariates included in the analyses. In this paper, we investigate the cost/benefit ratio of including covariates in the analysis of clinical trials with a continuous outcome. Within this context, we address the long-running question "What is the optimum number of covariates to include in a clinical trial?" To further improve the benefit/cost ratio of covariates, historical data can be leveraged to pre-specify the covariate weights, which can be viewed as the definition of a new composite covariate. Here we analyze the use of a composite covariate to improve the estimated treatment effect in small clinical trials. A composite covariate limits the loss of degrees of freedom and the risk of overfitting. [less ▲]

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See detailDevelopment of a theoretical model to predict retention times in gas chromatography
Gaida, Meriem ULiege; Franchina, Flavio Antonio; Stefanuto, Pierre-Hugues ULiege et al

Poster (2021, October)

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See detailDevelopment of a sensitive MEKC-LIF method for the analysis of synthetic cathinones and amphetamines Paul Emonts
Emonts, Paul ULiege; Avohou, Tonakpon Hermane ULiege; Hubert, Philippe ULiege et al

Poster (2021, October)

Synthetic cathinones (SCs) are phenylalkylamine compounds related to natural cathinone from Catha Edulis leaves. Given their structural similarities with amphetamines, these compounds are mainly drug of ... [more ▼]

Synthetic cathinones (SCs) are phenylalkylamine compounds related to natural cathinone from Catha Edulis leaves. Given their structural similarities with amphetamines, these compounds are mainly drug of abuse. Indeed, these substances constitute the second most frequently seized group of new psychoactive substances and counted more than 130 compounds in Europe (EMCDDA 2016). In addition to be sold on the illegal market, some of them are currently available online using various brand names as “bath salts”, taking advantage of a legislative void. In this context, reliable analytical tools are required to track these substances. The main objective of the present study was to develop a capillary electrophoresis separation method with laser induced fluorescence detection (CE-LIF) to analyze most frequently observed SCs. As these stimulants are frequently used as substitutes to these drugs, and especially in ecstasy, most common amphetamines were also included in the panel of 14 target analytes. Due to their lack of native fluorescence, analytes were labeled using fluorescein isothiocyanate isomer I (FITC). Design of experiments strategy was performed to optimize the labeling process [1]. The FITC/analyte ratio, pH of reaction buffer and reaction time were selected as factors of the DoE. The objective was to maximize the peak intensity observed in CE while keeping an easy and fast protocol. Moreover, the estimation of process precision (i.e. repeatability and intermediate precision) was performed simultaneously by including triplicates of the central point during each day of DoE experiments. Regarding the CE method, various BGE composition and additives were investigated in order to optimize the separation [2]. As non-ionic surfactants showed interesting selectivity, the development of a micellar electrokinetic capillary chromatography (MEKC) method was performed. The nature and concentration of non-ionic surfactants were deeply studied. The interest of polyethylene glycol ether surfactant was clearly demonstrated for the separation of these closely related compounds. To conclude, a reliable labeling process was optimized thanks to DoE approach. Regarding the separation, the high resolving power of MEKC combined to the high sensitivity of LIF detection (pg/mL order) seemed to be an appropriate tool for the screening of both legal and illegal drugs [less ▲]

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See detailHybrid Molybdenum-Tungsten Oxide Nanoparticles as Novel Plasmonic Materials for Electrochromic Smart Windows
Gillissen, Florian ULiege; Maho, Anthony ULiege; De Moor, Nicolas et al

Poster (2021, September 23)

Hybrid Molybdenum-Tungsten oxides nanomaterials are obtained by solvothermal synthesis. In comparaison with undoped WO3-x, a boost in the optical signature has been observed, which can be linked to a ... [more ▼]

Hybrid Molybdenum-Tungsten oxides nanomaterials are obtained by solvothermal synthesis. In comparaison with undoped WO3-x, a boost in the optical signature has been observed, which can be linked to a concentration increase of reduced species and oxygen vacancies in the material. The « MoWOx » powder is then wet-processed as thin film by spin coating and succesfully used as plasmonic EC material, dispalying a selective and independent modulation of both visible and NIR wavelengths as a function of the applied potential. In addition to the experimental data, theoretical simulations of the optical propoerties of the materials show good accordance between the model used and the data obtained from measurements [less ▲]

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See detailTisotumab Vedotin + Carboplatin in First-Line or + Pembrolizumab in Previously Treated Recurrent/Metastatic Cervical Cancer: Interim Results of ENGOT-Cx8/GOG-3024/innovaTV 205
Vergote, I.B.; Monk, B.J.; O'Cearbhaill, R.E. et al

Poster (2021, September 19)

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See detailMale and female hypogonadotropic hypogonadism associated with two novel non sense heterozygous mutations of Klotho beta gene (KLB)
VALDES SOCIN, Hernan Gonzalo ULiege; LIBIOULLE, Cécile ULiege; PETIGNOT, Sandrine ULiege et al

Poster (2021, September 17)

Clinical Case 1: A 15-year-old boy, with congenital deafness of the right ear, without olfaction disorders, consults for pubertal and growth retardation (1.59m, 47kg). Bone age of 14 years, GH: 6.4 ng/ml ... [more ▼]

Clinical Case 1: A 15-year-old boy, with congenital deafness of the right ear, without olfaction disorders, consults for pubertal and growth retardation (1.59m, 47kg). Bone age of 14 years, GH: 6.4 ng/ml after ITT, LHRH-stimulateable gonadotropins, testosterone-total 99ng/dl (28-1110 ng/dl). Pituitary MRI is normal. His father and sister had late puberty around the age of 16. The patient treated with GH and Sustanon, reaches 1.77m and 79 kg. At the age of 16, suffering from MS, like his father. At 18 years, the gonadic balance is re-evaluated, normal (bilateral testicular volume: 14 ml). Clinical case 2: A 30 years old woman (1.62m, 61 kg) consults for secondary amenorrhea and infertility after clomiphene stimulation. She is normal weighted. After some left hypoesthesic symptomatology, a brain neuro inflammatory pathology was suspected on MRI (several frontal hyper intense T2 lesions) without a precise diagnosis. No pituitary lesions were identified. During follow up, a normal pregnancy was obtained. She delivered a 3.3 kg girl in 2019 . Genetic analysis: A panel of 61 genes of hypogonadotropic hypogonadism found in case 1 an heterozygous variant KLB c.3092T>A, p.(Leu1031*). This new variant (likely pathogenic, class IV), causes the appearance of a premature stop codon in exon 5 of the KLB gene. In case 2, a novel mutation c.2230_2231insGGTT, p.(Ala744Glyfs*45) was confirmed, causing a frame shift and stop codon (since codon Ala744).. Discussion: We describe two novel non sense KLB mutations and for the first time, a reproductive phenotype in a female affected patient. In our series of 54 consecutive patients with congenital hypogonadotropic hypogonadism sequenced with a panel of 61 candidate genes, KLB mutations represents 3.7% . This prevalence is in line with the 4% finding of Xu. et al(EMBO Mol Med 2017). In the series of XU et al, patients with missense KLB mutations had (n= 9/13) a metabolic syndrome too, unlike our patients, carrying a nonsense mutation. In mice, the loss of the klb gene leads to delayed puberty, impaired estrogenic cycle, subfertility. The association with multiple sclerosis/brain inflammatory lesions is intriguing, so other family members will be studied. [less ▲]

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See detailInternational Symposium: Eroticism, Poetic Concretism, and Visuality (1960-1970)
Minuto, Maria Elena ULiege

Poster (2021, September 17)

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See detailStratigraphic architecture, sedimentology and structure of the Corinth Canal (Greece)
Caterina, Basile ULiege

Poster (2021, September 17)

The man-made Corinth Canal connects the Aegean Sea with the Corinth Gulf while displaying high steep walls allowing to study the sedimentological structure of this canal. This canal is supposed to be the ... [more ▼]

The man-made Corinth Canal connects the Aegean Sea with the Corinth Gulf while displaying high steep walls allowing to study the sedimentological structure of this canal. This canal is supposed to be the former strait which connected the gulf with the Aegean Sea. Therefore, the canal could be used as analogue to study tidal straits once its stratigraphic architecture, sedimentology and structure are defined. To do so, we used field observations associated with a 3D model done by drone imaging. With these data we observed a central horst, located at the central part of the canal and an associated graben called Isthmia. The top and NW parts of the canal section consist of a min. 20 m thick unit of conglomeratic tidal dune bedded deposits. These deposits are evidenced by the presence of asymmetrical herringbones, tidal dune bedded features and cross-stratification. These deposits may then totally propose a new paleostratigraphic interpretation for the Corinth Canal but also complete the “classical” tidal strait depositional model. In the regional context, such deposits confirm the probable connection between the Aegean Sean and the Corinth Gulf at ~300 ka. This connection faded due to the regional uplift and the activation of the major Kalamaki-Isthmia fault. [less ▲]

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See detailTimescale of Crystal Mush Storage in the Central Southern Volcanic Zone of Chile (CSVZ)
Billon, Melvyn ULiege; Charlier, Bernard ULiege; Namur, Olivier et al

Poster (2021, September 16)

During the last few decades, there has been an important change in paradigm in igneous petrology from the classic concept of a large melt-dominated magma chamber to a storage reservoir that is dominated ... [more ▼]

During the last few decades, there has been an important change in paradigm in igneous petrology from the classic concept of a large melt-dominated magma chamber to a storage reservoir that is dominated by crystal mush where the crystals form a framework in which melt is distributed. During eruption, these crystals may be unlocked from the mush and transported as individual macrocrysts or glomerocrysts. Time is a fundamental parameter in geology and particularly in volcanology where volcanic hazard must be assessed. If the process of rising magma from the surface reservoir is relatively fast, the process of crystal mush storing can take from centuries to thousands of years. The project focuses on constraining the timescales (t) of crystal growth (G) in the main storage region of several volcanoes (Osorno, Calbuco, Villarica, La Picada) of the Central Southern Volcanic Zone of the Andean arc (CSVZ) (Chile). These timescales will be obtained by combining experimentally determined growth rates of plagioclase, the main macrocryst in the studied volcanoes, and detailed plagioclase crystal size distributions (CSD). Experiments of plagioclase crystallization are performed on a natural basaltic andesite sample (from Osorno) that is representative of the CSVZ and more generally of arc magmatism. We particularly study the effect of melt composition and H2O content, an important parameter in subduction zone magmatism, on the growth rate of plagioclase. Cooling experiments at different rates (1°C/h, 3°C/h, …) are run at 1 atm (anhydrous) and 2 kbar (hydrous) and at an oxygen fugacity close to NNO. These conditions are constrained by results from our extensive petrological database on these volcanoes. The various experimental charges obtained are then polished, observed by different processes (SEM, electron microprobe, tomography), and texture is analyzed by segmentation with different software (GIMP, ImageJ), so as to compare the shape and growth of the crystals according to the conditions. Plagioclase crystal size distributions are also acquired on a selection of samples from the different volcanoes. Crystal size data obtained from high quality BSE images are then quantified with the software package ImageJ freeware to calculate the CSD plots. Using our data on growth rates (G) and the slope of these plots (-1/Gt) will enable us to extract information about the duration of crystal growth (t). [less ▲]

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See detailThe LASUGEO project: monitoring LAnd SUbsidence caused by Groundwater exploitation through gEOdetic measurements
Devleeschouwer, Xavier; Choopani, Atefe; Moreau, Aline ULiege et al

Poster (2021, September 15)

In the last decades, rapid urbanization, global climate change and uncontrolled anthropogenic transformations of the territory caused a relevant increase in geo-hazards events with huge economic and ... [more ▼]

In the last decades, rapid urbanization, global climate change and uncontrolled anthropogenic transformations of the territory caused a relevant increase in geo-hazards events with huge economic and social consequences. The dramatic increase of these events with environmental degradation highlights the importance of improving ground monitoring and natural resources management with a continuous exchange of knowledge between the scientific community and authorities in charge of environmental risk management. Since the late 1990s, SAR (Synthetic Aperture Radar) data allow measuring slow-moving ground deformations. In the last decades, the use of spaceborne InSAR (Interferometric SAR) has increased significantly thanks to the availability of large-area coverage, millimetre precision, high spatial/temporal data resolution and good cost-benefit. For the last 3 decades, the development of Multi-Temporal Interferometric SAR techniques (MT-InSAR), commonly grouped into PSI-like (Persistent Scatterers Interferometry) and SBAS-like (Small BAseline Subset) algorithms, has changed the way radar images can be exploited for geohazard monitoring (natural gas extraction, mining activities, groundwater overexploitation, karst or landslides processes, etc.). Most of the subsidence bowls mapped by the PSI technique in Belgium have been related to strong fluctuations of an aquifer implying at the surface ground deformations (Declercq et al., 2017; 2021). Besides, the recent dry years are related to ground stability problems in large areas of Flanders. Land subsidence poses significant problems. The most affected regions lie on compressible loose sediments. Any change in the piezometric heads modifies the pore pressure, which may induce consolidation if the geological formations are compressible. Geomechanical aspects are fully coupled to groundwater flow equations. If groundwater levels and pressures are restored, a partial rebound (uplift) corresponding to the elastic part of the geological formations is observed. Consolidation and elastic rebound processes occur in confined and unconfined conditions. The most sensitive parts of the concerned aquifers contain clay, loam or peat lenses but consolidation may occur mostly in the underlying and overlying layers that are often less permeable and more compressible than the aquifer itself. In this case, it is largely a delayed process occurring as far as the pore pressure variation slowly propagates in the low permeability (aquitard) layers. We propose to confront the results of the PSinSAR technique data with hydrogeological groundwater models and two other geodetic techniques: GNSS and gravimetry. LASUGEO focusses on ground deformations in different areas in Belgium: the deep aquifer system of western Flanders, the Tertiary aquifer system in Central Flanders, the Antwerp area, the Leuven area and the Brussels Region. The possible groundwater overexploitation needs to be established through a transient hydrogeological model considering all the stress factors applied to the aquifers. The estimated compaction in the subsiding bowls will be compared with 1D geomechanical model results. The latter will be performed using geotechnical effective stresses as deduced from the pore pressure distribution from the hydrogeological model (Dassargues et al., 1989). These different steps will be done by the partners of the LASUGEO project that are involved in the different case study areas. [less ▲]

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