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See detailÉVOLUTION DE LA TENEUR EN EAU LE LONG D’UNE TOPOSEQUENCE FORESTIERE ARGILO-LIMONEUSE
Deraedt, Deborah ULiege; Colinet, Gilles ULiege; Degré, Aurore ULiege

in Milieux Poreux et Transferts Hydriques (in press)

For the hydrological modeling of forested watersheds, the understanding of the forest hydrodynamic is essential. This study focusses on the hydrology of a Belgian forested plot with high stoniness and ... [more ▼]

For the hydrological modeling of forested watersheds, the understanding of the forest hydrodynamic is essential. This study focusses on the hydrology of a Belgian forested plot with high stoniness and steep slope. The soil water content is monitored at several positions on the toposequence and at different depth. During rain events, peak in soil water content are observed in different depth depending on the position along the toposequence. [less ▲]

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See detailsynthéticité et intuition en mathématiques contemporaines : Kant au-delà de Kant
Mazurkiewicz, Stany ULiege

in Eikasia. Revista de Filosofia. (in press)

Ce texte entend réévaluer l'idée de "pure synthèse intellectuelle" que l'on trouve chez Kant. Celle-ci cadre avec la pratique mathématique et métamathématique postérieure à Kant. Elle permet de dépasser l ... [more ▼]

Ce texte entend réévaluer l'idée de "pure synthèse intellectuelle" que l'on trouve chez Kant. Celle-ci cadre avec la pratique mathématique et métamathématique postérieure à Kant. Elle permet de dépasser l'alternative entre l'intuitionnisme développé dans la Critique de la raison pure et la fondation de la mathématique sur une logique formelle analytique. Je montre que cette idée convient à Bolzano et à Dedekind, dont je soutiens que les projets sont irréductibles à du logicisme et qui sont dès lors bien plus "kantiens" qu'il n'y paraît. [less ▲]

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See detailTwo-loop-induced neutrino masses: A model-independent perspective
Aristizabal Sierra, Diego ULiege

in PoS Proceedings of Science (in press)

We disucuss Majorana neutrino mass generation mechanisms at the two-loop order. After briefly reviewing the systematic classification of one-loop realizations, we then focus on a general two-loop ... [more ▼]

We disucuss Majorana neutrino mass generation mechanisms at the two-loop order. After briefly reviewing the systematic classification of one-loop realizations, we then focus on a general two-loop classification scheme which provides a model-independent catalog for neutrino mass models at the two-loop order [less ▲]

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See detailPaper Formats of the Mamluk Period: The Contribution of Mamluk Chancery Paper
Bauden, Frédéric ULiege

in Journal of Islamic Manuscripts (in press)

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See detailClinical and neuroimaging improvements after apomorphine treatment in a patient with chronic disorders of consciousness following brain hemorrhage
Sanz, Leandro ULiege; Lejeune, Nicolas; Blandiaux, Séverine ULiege et al

in Brain Injury (in press)

Background: There are few available therapeutic options to promote recovery among patients with disorders of consciousness (DOC). Among pharmacological treatments, apomorphine, a dopamine agonist, has ... [more ▼]

Background: There are few available therapeutic options to promote recovery among patients with disorders of consciousness (DOC). Among pharmacological treatments, apomorphine, a dopamine agonist, has exhibited promising behavioral effects in traumatic brain injury. Its efficacy among patients with non-traumatic brain injury has never been documented and its action on brain activity remains unknown. We report the case of a patient with DOC following intracranial hemorrhage, who was treated with apomorphine in a prospective open-label study. Methods/design: A 47-year-old woman with chronic DOC (minimally conscious state; MCS) following spontaneous rupture of a left carotidal aneurysm (132 days since onset), was treated with apomorphine for 30 days. The drug was administered via subcutaneous infusions 12 hours per day, with escalating doses up to 6 mg/h. The patient was monitored 30 days before initiation of therapy, during treatment and 30 days after withdrawal, using the Coma Recovery Scale – Revised (CRS-R). High-density electroencephalography (hdEEG) and fluorodeoxyglucose positron emission tomography (FDG-PET) were acquired before and after treatment. Outcome measures included CRS-R diagnosis, FDG-PET standardized uptake values, a multivariate classifier integrating 68 individual hdEEG markers and hdEEG functional connectivity using debiased weighted phase lag index. Results: Before treatment, CRS-R scores were compatible with a diagnosis of unresponsive wakefulness syndrome (UWS) in 8/9 evaluations, and with a MCS- only once. During treatment, the patient was diagnosed as UWS in 2/8 evaluations, MCS- in 5/8 evaluations and MCS+ once, characterized by the presence of reproducible response to command. After treatment withdrawal, she was diagnosed UWS once and MCS- in 4/5 evaluations. Compared to 54 healthy controls, FDG-PET whole brain metabolism revealed a 59% metabolic drop before treatment and 51% after treatment, with increases in right temporal, parietal and frontal cortical areas. The multivariate classifier using resting-state hdEEG data was in favor of a UWS before treatment, while it indicated a MCS after treatment. Most of the individual markers increased after treatment, including alpha and beta spectral power, spectral entropy, Kolmogorov complexity and permutation entropy. Functional connectivity analyses also indicated an increase in network centrality predominant in the alpha frequency band after treatment compared to before treatment. Discussion: After treatment with apomorphine, this patient showed improvements both at the clinical and neuroimaging levels. While signs of consciousness were only observed once at baseline, most of the assessments performed during and after treatment led to a diagnosis of MCS. Notably, a reproducible response to command was observed once during treatment, leading to a change of diagnosis. Brain activity measures all increased after treatment compared to before treatment. These multimodal improvements suggest that apomorphine may be efficient to promote the recovery of non-traumatic DOC patients, and that its action can be measured through different changes in brain imaging markers. Clinical trial identifiers: EudraCT 2018-003144-23; Clinicaltrials.gov NCT03623828 [less ▲]

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See detailHow to give something as a present to the tomb owner in Old Kingdom daily-life scenes
Motte, Aurore ULiege

in Egyptian & Egyptological Documents, Archives, Libraries (in press), V

The aim of this paper is to describe the variety of ways by which the common workers speak to or offer something to the owner of a private tomb in the Old Kingdom daily-life scenes. Moreover, it retraces ... [more ▼]

The aim of this paper is to describe the variety of ways by which the common workers speak to or offer something to the owner of a private tomb in the Old Kingdom daily-life scenes. Moreover, it retraces the development of dedicatory formulas in Reden und Rufe from the 5th Dynasty to the end of the 6th Dynasty with a short overview of the subsequent speech captions. [less ▲]

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See detailThe role of conservators: an international survey on conservation within contemporary art collections
D'Haenens, Manon ULiege

in CeROArt: Conservation, Exposition, Restauration d'Objets d'Art (in press)

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See detailAge effect on the hierarchical structure of paranoia in the general population: the role of rumination and thought suppression.
Della Libera, Clara ULiege; Laroi, Frank ULiege; Raffard, Stéphan et al

in Schizophrenia Bulletin (in press)

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See detailAux marges des congrès de Westphalie. La diplomatie des secrétaires au risque du perfectionnement des pratiques diplomatiques (1648-1650)
Regibeau, Julien ULiege

in Enquêtes. revue de l’école doctorale « Histoire moderne et contemporaine » (in press)

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See detailDisentangling false perceptions elicited by white noise in people with auditory hallucinations: The role of sound frequencies and expectations.
Laloyaux, Julien ULiege; Specht, K; Hugdahl, K et al

in Schizophrenia Bulletin (in press)

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See detailThermography-inspired processing strategy applied on shearography towards nondestructive inspection of composites
Kirkove, Murielle ULiege; Zhao, Yuchen ULiege; Blain, Pascal ULiege et al

in Proceedings of SPIE: The International Society for Optical Engineering (2019, June 21), 11056

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See detailShearography inspection of monolithic CFRP composites: finite element modeling approach for assessing an adequate strategy of artificial defects representing delamination
Vandenrijt, Jean-François ULiege; Xiong, Hu; Lequesne, Cédric et al

in Proceedings of SPIE: The International Society for Optical Engineering (2019, June 21), 11056

Delamination in carbon fiber reinforced polymer (CFRP) laminated composites is an important problem for industry. Nondestructive inspection (NDI) methods aim at locating such defects. Shearography is a ... [more ▼]

Delamination in carbon fiber reinforced polymer (CFRP) laminated composites is an important problem for industry. Nondestructive inspection (NDI) methods aim at locating such defects. Shearography is a full-field NDI method that could be considered to detect them. Reference plates for assessing performances of NDI methods for detecting delamination use artificial defects of several types introduced in reference CFRP matrices. Although they are standardized for usual ultrasound testing, these artifacts are not necessarily adequate for shearography. We have studied this problem by comparing shearography experiment and simulations by finite element analysis. We show the convergence with experiments on the case of flat bottom hole artifacts. Then we discuss the adequateness of other artifacts through simulations. [less ▲]

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See detailA Semantic Retrieval System for Remote Sensing Web Platforms
Nys, Gilles-Antoine ULiege; Kasprzyk, Jean-Paul ULiege; Hallot, Pierre ULiege et al

in International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2019, June 05), XLII-2(W13), 1593-1599

This paper proposes a solution to reduce the semantic gap between final users and data/processing providers in a web market place dedicated to remote sensing products. Nowadays, search engine are common ... [more ▼]

This paper proposes a solution to reduce the semantic gap between final users and data/processing providers in a web market place dedicated to remote sensing products. Nowadays, search engine are common tools on the Internet. Users are accustomed to use them and used to get tabular classification of provided answers. These smart agents are set up to answer basic questions using automatic pages redirection or chitchat. In this research, to ensure coherence between user’s requests and platform answers, natural language processing algorithms and knowledge graphs are integrated within a web platform thanks to a NoSQL graph database connected to open thesauri and Geographic Information Systems (GIS). Therefore, the most pertinent services can be proposed based on input sentences including non-technical vocabulary but also geographical components (the user interface includes a text area and an interactive map). While processing chains and remote sensing ontologies were presented in one of our previous studies, this article focuses on natural languages algorithms and knowledge mining. [less ▲]

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See detailMid-Air: A multi-modal dataset for extremely low altitude drone flights
Fonder, Michaël ULiege; Van Droogenbroeck, Marc ULiege

in IEEE Conference on Computer Vision and Pattern Recognition Workshops Proceedings (2019, June)

Flying a drone in unstructured environments with varying conditions is challenging. To help producing better algorithms, we present Mid-Air, a multi-purpose synthetic dataset for low altitude drone ... [more ▼]

Flying a drone in unstructured environments with varying conditions is challenging. To help producing better algorithms, we present Mid-Air, a multi-purpose synthetic dataset for low altitude drone flights in unstructured environments. It contains synchronized data of multiple sensors for a total of 54 trajectories and more than 420k video frames simulated in various climate conditions. In this work, we motivate design choices, explain how the data was simulated, and present the content of the dataset. Finally, a benchmark for positioning and a benchmark for image generation tasks show how Mid-Air can be used to set up a standard evaluation method for assessing computer vision algorithms in terms of robustness and generalization. We illustrate this by providing a baseline for depth estimation and by comparing it with results obtained on an existing dataset. The Mid-Air is publicly downloadable, with additional details on the data format and organization, at http://midair.ulg.ac.be [less ▲]

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See detailExploring the Concept of Customer-Perceived Intimacy in Healthscapes
Martens, Carmen ULiege; Delcourt, Cécile ULiege; Herssens, Jasmien

in Forthcoming (2019, June)

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See detailA compact multichannel spectrometer for label-free monitoring of biochips for point-of-care testing
Dortu, Fabian; Horsten, Hendrik V.; Bernier, Damien et al

in Proceedings of SPIE: The International Society for Optical Engineering (2019, June)

We present three optical multi-channels spectrometers for the interrogation of label-free biosensors based on different kinds of transducers : resonant nanopillars (RNP), microring resonators (MRR ... [more ▼]

We present three optical multi-channels spectrometers for the interrogation of label-free biosensors based on different kinds of transducers : resonant nanopillars (RNP), microring resonators (MRR), localized and propagative surface plasmon resonance (LSPR and SPR). Light is collected from the multi-channel biosensors (up to 12-channels) with optical fibers and is remapped to a packed straight line forming the input slit of the spectrometers. The combination of high resolution CMOS sensors and embedded signal processing makes it possible to extract the resonant wavelengths of the transducers with a precision in the range of 1-20 pm depending on the type of transducer. [less ▲]

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See detailARTHuS: Adaptive Real-Time Human Segmentation in Sports through Online Distillation
Cioppa, Anthony ULiege; Deliège, Adrien ULiege; Istasse, Maxime et al

in IEEE Conference on Computer Vision and Pattern Recognition Workshops (CVPRW) Proceedings (2019, June)

Semantic segmentation can be regarded as a useful tool for global scene understanding in many areas, including sports, but has inherent difficulties, such as the need for pixel-wise annotated training ... [more ▼]

Semantic segmentation can be regarded as a useful tool for global scene understanding in many areas, including sports, but has inherent difficulties, such as the need for pixel-wise annotated training data and the absence of well-performing real-time universal algorithms. To alleviate these issues, we sacrifice universality by developing a general method, named ARTHuS, that produces adaptive real-time match-specific networks for human segmentation in sports videos, without requiring any manual annotation. This is done by an online knowledge distillation process, in which a fast student network is trained to mimic the output of an existing slow but effective universal teacher network, while being periodically updated to adjust to the latest play conditions. As a result, ARTHuS allows to build highly effective real-time human segmentation networks that evolve through the match and that sometimes outperform their teacher. The usefulness of producing adaptive match-specific networks and their excellent performances are demonstrated quantitatively and qualitatively for soccer and basketball matches. [less ▲]

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See detailRelationships between Pb, As, Cr, and Cd in soil and water in agricultural and industrial areas with heavy metals contents from individual cow milks
Zhou, Xuewei; Soyeurt, Hélène ULiege; Zheng, Nan et al

in Journal of Dairy Science (2019, June), 102(1), 190

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See detailInternet of Things: learning and practices. Application to Smart City
Debauche, Olivier ULiege; Mahmoudi, Saïd; Mahmoudi, Sidi Ahmed

in IEEE Explore (2019, May 13)

Internet of Things is becoming widely present in our daily life. In fact, more and more devices able to interact together have been recently designed and launched in the market. Learning Internet of ... [more ▼]

Internet of Things is becoming widely present in our daily life. In fact, more and more devices able to interact together have been recently designed and launched in the market. Learning Internet of Things technologies is becoming unavoidable in education. In this paper, we propose a practical approach allowing to progressively learn, by practice the essential concepts of Internet of Things applied to Smart Cities. From basic knowledge of python language and the use of microcontrollers Pycom such as LoPy, students can develop skills and also smart applications in the field of Internet of Things. [less ▲]

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See detailAssociation of SMA neonatal screening with other screening tests
BOEMER, François ULiege

in Neuromuscular Disorders (2019, May 11)

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See detailIn-house techniques for SMA screening test: validation
BOEMER, François ULiege

in Neuromuscular Disorders (2019, May 10)

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See detailPresentation : Blockchain: A novel approach for the consensus algorithm using Condorcet Voting procedure
Vangulick, David ULiege

in IEEE Catalog Number: CFP19S63-ART (2019, April)

Presentation support of the full paper submitted and accepted for the conference IEEE DAPPCON

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See detailSyndecan-4 is increased in osteoarthritic knee, but nor ip or shoulder, articular hypertrophic chondrocytes
Sanchez, Christelle ULiege; Lambert, Cécile ULiege; Dubuc, Jean-Emile et al

in Osteoarthritis and Cartilage (2019, April), 27(Suppl 1), 159-160

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See detailTumor modifications recorded with IVIM and DCE-MRI after Neoadjuvant radiotherapy.
LALLEMAND, François ULiege; LEROI, Natacha ULiege; Bahri, Mohamed Ali ULiege et al

in Radiotherapy and Oncology (2019, April), 133(Supplement 1), 284-285

Purpose or Objective Neoadjuvant radiotherapy (NeoRT) improves tumor local control and facilitates tumor resection in many cancers. We hypothesized anti-cancer treatments (i.e. radiotherapy) modify tumor ... [more ▼]

Purpose or Objective Neoadjuvant radiotherapy (NeoRT) improves tumor local control and facilitates tumor resection in many cancers. We hypothesized anti-cancer treatments (i.e. radiotherapy) modify tumor microenvironment and could potentially impact distant metastases occurrence. Previously, we developed a pre-clinical model demonstrating an impact of NeoRT schedule and the timing of surgery on metastatic spreading (Leroi et al. Oncotarget 2015). Here, we aim to identify by fMRI noninvasive markers reflecting NeoRT related tumor microenvironment modifications that could predict the best timing for performing surgery and avoiding tumor spreading. Material and Methods To briefly delineate the NeoRT model, MDA-MB 231 tumor cells implanted in the flank of SCID mice were locally irradiated with 2x5Gy when tumor reached 100mm3 and then surgically removed at different time points. We performed fMRI, Diffusion Weighted (DW) and Dynamic Contract enhancement (DCE) – MRI, before RT and every 2 days between RT and surgery. We acquired 8 slices of 1 mm thickness and 0.5 mm gap with an “in plane voxel resolution” of 0.5 mm. For DW-MRI, we performed FSEMS (Fast Spin Echo MultiSlice) sequences, with 9 different Bvalue (from 40 to 1000) and B0. We performed IVIM (IntraVoxel Incoherent Motion) analysis to obtain information on intravascular diffusion, related to perfusion (F: perfusion factor) and subsequently tumor vessels perfusion. For DCE-MRI, we performed a T1 mapping with multiple TR and DCE acquisition with 200 repetitions of 3 sec each and gadolinium IV injection after 10 repetitions. We performed semi-quantitative analysis. We validated tumor perfusion by immunochemistry with injection of FITC-dextran IV 3 min before surgery and CD31 labelling. Human Ki67 was used for lung metastases labelling and quantification. Results After the tumor irradiation, we observed a significant and transient increase at day 6 (60% of the basal value (n=6, p<0,05)) of F and D* parameters related to perfusion. The other parameters of the DW-MRI, ADC and D presented no modifications. The sham irradiated tumors used as control showed no modifications of all fMRI parameters. At the same timing, 6 days post-radiotherapy, DCE-MRI significantly demonstrated a WhashinSlope (n=13, p<0,05) increase. Immunochemistry confirmed the increase of tumor perfusion when surgery is performed at day 6. The sham irradiated tumors never demonstrated such changes. Finally, when surgery is performed on tumor increased perfusion measured by fMRI, it demonstrated a burst of lung metastasis compared to the other timings. Conclusion We showed a significant difference in perfusion-related parameters with fMRI and immunochemistry at a specific time point after NeoRT. These modifications are correlated with an increase of metastasis spreading related to surgery procedure. These results open new perspectives in the personalized medicine and MRI guided surgery timing after NeoRT. [less ▲]

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See detailDiagnostic accuracy of a CRS-R modified score in patients with disorders of consciousness.
Annen, Jitka ULiege; Filippini, Maria Maddalena ULiege; Bonin, Estelle ULiege et al

in Brain Injury (2019, March 16)

Introduction The Coma Recovery Scale-Revised (CRS-R) is the gold standard diagnostic tool for assessing patients with disorders of consciousness (DOC) after severe acquired brain injury (Giacino, Kalmar ... [more ▼]

Introduction The Coma Recovery Scale-Revised (CRS-R) is the gold standard diagnostic tool for assessing patients with disorders of consciousness (DOC) after severe acquired brain injury (Giacino, Kalmar and Whyte, 2004; Seel et al., 2010). Differential diagnosis of DOC includes the unresponsive wakefulness syndrome (UWS;(Laureys et al., 2010)), characterized by the recovery of eye-opening but no behavioral evidence of self or environmental awareness, and the minimally conscious state (MCS; (Giacino et al., 2002)) defined by clearly discernible but inconsistent behavioral signs of conscious awareness. The CRS-R assesses reflexes and cognitively mediated behavior in six domains, namely auditory (4 items), visual (5 items), motor (6 items), oromotor (3 items), communication (2 items) and arousal (3 items). Items in every subscale are hierarchically ordered (i.e. reflexive to cognitively-mediated behaviors; higher level behaviors correspond to higher level of neurologic functioning and ability to demonstrate lower-level behaviors or disappearance of pathological behaviors as sign of recovery) and can be used to infer the patient’s level of consciousness (La Porta et al., 2013; Gerrard, Zafonte and Giacino, 2014). Several studies on DOC investigating markers of consciousness, recovery and treatment used the CRS-R total score (i.e. addition of the highest scores reached for each subscale) as regressor in neuroimaging analyses (Bruno et al., 2012; Thibaut et al., 2012; Margetis et al., 2014; Bagnato et al., 2015). However, ignoring the hierarchy of the subscales in the CRS-R total score reduces the sensitivity for the diagnosis of MCS patients (i.e., 100% specificity for UWS but false negative diagnostic error of 22%, with a cut-off CRS-R total score of 10 (Bodien et al., 2016)). In addition, the ordinal nature of the CRS-R total score make it limited to use with parametric statistical tests (e.g., requiring normal distribution). A solution to this problem has been proposed by Sattin and colleagues (2015) who computed a CRS-R modified score (CRS-R MS1), by considering reflexes and cognitively mediated behaviors separately, reliably distinguishing between UWS and MCS patients. These authors also argue that the interpretation of the total CRS-R scores is limited due to “the underlying assumption that if a patient is able to show higher-level behaviors, he/she is also able to show lower-level responses”. Sattin et al. (2015) propose to account for the number of presented responses in every subscale (i.e., every items in a subscale should be assessed and scored). One major drawback to this approach is that according to the CRS-R guidelines, the assessor should start assessing the highest item and move to the next subscale once an item is scored, in line with the hierarchical organization of the scale. This means that, if the CRS-R is performed according to the guidelines (for which the CRS-R has been validated), the CRS-R modified score cannot be calculated. Even if assessing all items might be valid, it is unlikely to be done in many clinical and research settings as it would increase assessment time and fatigue the patient. We here propose to adapt the CRS-R MS1 by considering only the highest score reached on every subscale, respecting the CRS-R guidelines. Methods One-hundred twenty-four patients admitted to the University Hospital of Liège were assessed multiple times with the CRS-R, at least once including the assessment of all items. Patients for whom the CRS-R assessment including all items provided the same diagnosis as the patient’s final diagnosis were selected. The study was approved by the ethics committee of the University Hospital of Liège and the legal guardians of patients gave written informed consent for participation in the study, in accordance with the Declaration of Helsinki. The CRS-R total score and two CRS-R MS were calculated for every patient. The CRS-R MS combines scores for reflexes and cognitive behaviors of every CRS-R subscale which can be used to obtain the CSR-R MS from a transposition matrix. The CRS-R MS1 was calculated as previously described (Sattin et al., 2015), and the CRS-R MS2 only used the highest score in every subscale (i.e., assuming that lower items were successful). Statistics were performed in R (R Core team, 2012). We assessed group differences in age (two sample t-test), time since injury (two sample t-test) and etiology (χ2 test). Receiver Operating Characteristic were calculated to obtain the sensitivity and specificity at several classification thresholds (package pROC (Robin et al., 2011)). We calculated the correlation between the CRSR MS1 and CRSR MS2 using Pearson correlation, and both scores with the CRS-R total score using Spearman correlation. Finally, we used a Kolmogorov-Smirnoff test to evaluate whether CRSR MS1 and CRSR MS2 come from different distributions (i.e., if one approach provides additional information over the other). Results Eighty-five MCS patients (26 females; mean age 40.4 (SD±17.4) years old; 43 traumatic; mean time since injury 2.7 (SD±4.0) years) and 39 UWS patients (14 females; mean age 50.6 (SD±16.5) years old; 29 traumatic; mean time since injury 1.2 (SD±1.8) years) were included in the study. MCS patients were older (t(77.6)-3.15, p<0.002 95%CI[-16.7, -3.7]), were in a more chronic stage (t(121.9)=2.9, p = 0.005, 95%CI[974,427]), and suffered more often from a traumatic brain injury (χ2=6.8, p = 0.01) than UWS patients. The ROC analysis for both MS showed an AUC of 1 (cut-off:8.315, 100% specificity and sensitivity). The ROC analysis for the CRS-R total score showed an AUC of 0.94 (cut-off:9, sensitivity = 100%, specificity = 67%). A correlation was found between the CRSR total score and both the CRSR MS1 (r = 0.94, p < 0.0001, figure 1A) and CRSR MS2 (r = 0.96, p < 0.0001, figure 1B). The two CRS-R MS correlated (r = 0.96, p = 0.0001, figure 1C). CRSR MS1 and CRSR MS2 were drawn from the same distribution (D(124)= 0.13, p = 0.25). Discussion CRSR MS2 correlated strongly with the CRSR MS1, and perfectly discriminated UWS from MCS patients. As for accurate diagnosis the CRS-R should be repeated (preferably five times (Wannez et al., 2018)) short assessments are preferred, and possibly also reduce effects of fatigue. Second, the CRSR MS2 can be calculated with CRS-R assessments performed according to the CRS-R guidelines, facilitating its use in clinical environments, and in research settings where CRSR MS2 can be used pro- and retrospectively for research protocols. Furthermore, the results indicate that the two modified scores share the same distribution. This suggests that assessing all CRS-R items as proposed previously does not significantly contribute to the stratification of patients. The CRSR MS2 code is available via: Github A remaining limitation of the proposed score is that it does not allow to distinguish MCS minus (i.e. showing language independent signs of awareness, like visual pursuit) from MCS plus (i.e. showing language dependent signs of awareness) patients, or emergence from MCS. However, a clear consensus about the diagnostic criteria is needed before an updated modified score can be provided. In conclusion, the current analyses show that the calculation of the CRS-R modified score using the highest item in every subscale is valid for clinical diagnosis, and provides perspective for its use for research. Figure Figure 1. Correlation between the CRS-R total score and the CRS-R MS1 (1A), CRSR MS2 (1B), and between the two modified CRS-R scores (1C). MCS plus patients are here characterized by command following, intelligible verbalization and/or intentional communication. Acknowledgements This project has received funding from the University and University Hospital of Liege, the Belgian National Funds for Scientific Research (FRS-FNRS), the European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2) the Luminous project (EU-H2020-fetopenga686764), the Center-TBI project (FP7-HEALTH- 602150), the Public Utility Foundation ‘Université Européenne du Travail’, “Fondazione Europea di Ricerca Biomedica”, the Bial Foundation, the Mind Science Foundation and the European Commission, the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 778234, European Space Agency (ESA) and the Belgian Federal Science Policy Office (BELSPO) for their support in the framework of the PRODEX Programme. CC is a post-doctoral Marie Sklodowska-Curie fellow (H2020-MSCA-IF-2016-ADOC-752686), and SL is research director at FRS-FNRS. We are highly grateful to the members of the Liège Coma Science Group for their assistance in clinical evaluations, and we thank all the patients and their families and the Neurology department of the University hospital of Liège. [less ▲]

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See detailNew concepts in liver regeneration mechanisms in human severe alcoholic steatohepatitis.
Lejeune, A; Starkel, P; Louvet, A et al

in Acta Gastro-Enterologica Belgica (2019, March), 82(1), 12

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See detailThe condition of orally fed patients in ICU: an observational study.
MATHY, Xavier ULiege; ROUGIER, Loïc ULiege; FADEUR, Marjorie ULiege et al

in Critical Care (2019, March), 23(Suppl 2), 267

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See detailValidation des mouvements de la mandibule pour mesurer le sommeil par comparaison directe à la polysomnographie et à l’actimetrie
Chakar, Bassam; Senny, Frédéric ULiege; POIRRIER, Anne-Lise ULiege et al

in Médecine du Sommeil (2019, March), 16(1), 57

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See detailThrough patients and professionals representations on patient partnership of care: the exploration of an ambiguous consensus – Preliminary results
Voz, Bernard ULiege; Ortiz Halabi, Iness ULiege; Pétré, Benoît ULiege et al

in Archives of Public Health (2019, February 28)

Background: Patient engagement in health care system has been regarded as a lever for the general improvement of the health system. Many models illustrate and participate in this change. One of them ... [more ▼]

Background: Patient engagement in health care system has been regarded as a lever for the general improvement of the health system. Many models illustrate and participate in this change. One of them proposes a patient-partnership, challenging the whole health system, from direct care to policy making. In a context where the Belgian health system is put into question, the relevance of patient participation has to be challenged. This exploratory study is aimed at exploring the representations, experiences and expectations towards these models. Through this contribution, we will highlight the understanding of a partnership in health for patients and professionals. <br /> <br />Methods: As part of a larger Interreg research project, a qualitative approach has permitted an in-depth comprehension of patients and hospital professionals representation toward the partnership model. A purposive sample of thirty patients, suffering from cancer, diabetes, cardiovascular or pulmonary diseases, has been met in six focus groups. Thirty professionals, nurses and specialist physician in charge of chronic patients, have taken part in semi-structured interviews. Thematic analysis was used to organise the data. <br /> <br />Results: Patients and professionals share common basis for partnership, perceiving it as positive and, in some way, already happening. Both patients and professionals mention, among other things, the importance of common language, listening skills and team work. Beyond these discourses, some divergences appear when considering what partnership could mean in practice. As an example, information sharing is a key debate for the actors, who don’t agree about what should be shared, how or with whom. Furthermore, if patients and professionals easily identify what a partnership should be in direct care, they struggle to conceive one at other levels. <br /> <br />Conclusions: This analysis urges the health actors to face their divergence of opinions about interdisciplinarity, knowledge, and the sharing of information. These results constitute an initial trigger for the development of grounded interventions. [less ▲]

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See detailLe bouleau, une essence d'avenir !
Dubois, Héloïse ULiege

in Forêt.Nature (2019, February 26)

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See detailSurgical Simulation in Temporal Bone Surgical Radio-Anatomy Learning
ROGISTER, Florence ULiege; SALMON, Caroline ULiege; GHUYSEN, Alexandre ULiege et al

in B-ENT (2019, February 23)

Introduction and Aim: We aimed to evaluate high-fidelity virtual reality simulation in learning of temporal bone radio-anatomy during ENT residency. Methods: Fifteen ENT residents completed a radiological ... [more ▼]

Introduction and Aim: We aimed to evaluate high-fidelity virtual reality simulation in learning of temporal bone radio-anatomy during ENT residency. Methods: Fifteen ENT residents completed a radiological temporal bone anatomical testing before and after five training sessions on the VOXEL-MAN Tempo® surgical simulator. Secondary investigation: residents also completed a personal subjective assessment after these training session and residents’ technical skills were assessed on cadaveric temporal bones. Results: Primary outcome: Residents significantly improved their performance on the temporal bone radiological anatomy test after completing virtual training on the simulator. Secondary outcomes: The personal assessment survey indicated that 100% of the residents would integrate this virtual tool within the learning methods. No significant correlation was found between virtual simulator performances and surgical performances on cadaveric model, but a significant correlation was shown between the anatomical testing result and the performances on cadaveric model. Conclusions: This study suggested that a high-fidelity virtual reality simulator, the VOXEL-MAN Tempo® device, improved teaching of temporal bone anatomy and specifically increased trainees’ practical knowledge regarding radiological anatomy of temporal bone. [less ▲]

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See detailTraduction et analyse par des experts d'une brochure consacrée à l'auto-gestion après un « Whiplash »
Demoulin, Christophe ULiege; Taret, R; Otero, J et al

in Kinesitherapie, La Revue (2019, February), 19(206), 105-106

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See detailTest de dissociation thoraco-lombaire pour les patients lombalgiques chroniques : une évaluation par analyse vidéo est-elle envisageable ?
Demoulin, Christophe ULiege; Matheve, T; MICHEL, Laurie ULiege et al

in Kinesitherapie, La Revue (2019, February), 19(206), 44-45

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See detailDyskinésie scapulaire et kinésiotape : analyse électromyographique
Tooth, Camille ULiege; Schwartz, Cédric ULiege; Colman, David ULiege et al

in Kinesitherapie, La Revue (2019, February), 206

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See detailTraduction en français et intérêt de la grille ECHOWS pour évaluer l'anamnèse en physiothérapie
Barde-Cabusson, Y; Demoulin, Christophe ULiege; Bornheim, Stephen ULiege et al

in Kinesitherapie, La Revue (2019, February), 19(206), 60-61

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See detailUn outil d'apprentissage ludique pour améliorer le raisonnement clinique en kinésithérapie neuromusculo- squelettique : « Le jeu des 8 familles d'hypothèses »
Hage, Renaud; Fourré, Antoine; Demoulin, Christophe ULiege et al

in Kinesitherapie, La Revue (2019, February), 19(206), 45-46

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See detailMarket analysis of recycled sands and aggregates in North-West Europe: drivers and barriers
Delvoie, Simon ULiege; Zhao, Zengfeng ULiege; Michel, Frédéric ULiege et al

in Conference Series Earth and Environmental Science (2019, February)

Construction and demolition wastes (C&DW) are estimated at one third of total wastes generated in the European Union (EU) and represent the main flux in volume. Inert materials (e.g. concrete, bricks ... [more ▼]

Construction and demolition wastes (C&DW) are estimated at one third of total wastes generated in the European Union (EU) and represent the main flux in volume. Inert materials (e.g. concrete, bricks, tiles and ceramics) constitute the largest fraction of construction and demolition wastes. These wastes can be recovered as secondary raw materials after a recycling process resulting in the production of recycled sands and aggregates. The market for recycled sands and aggregates is however complex and sensitive. It can be affected by many parameters and may be very variable from one region to another, even in the same country. A quantitative analysis of some market variables is carried out in five NW European countries: Belgium, France, Germany, Luxembourg and the Netherlands. For achieving this analysis, attention is paid to the following data/parameters: generation of inert construction and demolition wastes, production of recycled sands and aggregates and production of natural sands and aggregates. Since the market of recycled products is also governed by transportation costs (mainly transported by road), the study has also compiled data on the density of recycling plants for construction and demolition wastes, the density of pits and quarries extracting natural materials, the density of inert landfills and taxes applied for C&DW landfilling. National/regional legislation and requirements are also included in the analysis. Based on the compiled data and objective reasons, the market of recycled sands and aggregates is more developed and more suitable in the Netherlands and in Flanders (North of Belgium) than in the other investigated countries/regions. [less ▲]

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See detailIntérêt des microcourants pour prévenir/limiter la survenue de DOMS après un effort excentrique
Demoulin, Christophe ULiege; Hoyaux, A; Bornheim, Stephen ULiege et al

in Kinesitherapie, La Revue (2019, February), 19(206), 75-76

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See detailEvaluation de la mobilité lombaire: Schober or not Schober?
Jacquemin, Denis ULiege; Demoulin, Christophe ULiege; Botton, Anne-Sophie et al

in Kinesitherapie, La Revue (2019, February), 19(206), 82-83

The aim of this study was to verify the validity of the Modified Schober test by checking the real positioning of its benchmarks regarding the spinal skeleton. Study performed on a sample of 42 patients ... [more ▼]

The aim of this study was to verify the validity of the Modified Schober test by checking the real positioning of its benchmarks regarding the spinal skeleton. Study performed on a sample of 42 patients with low back pain via CT or MRI. In 64.3% of cases, the upper marker was below L1, at an average distance of 2.15 cm. Our study therefore questions the validity of the modified Schober test to identify the upper end of the lumbar spine. [less ▲]

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See detailLa tDCS en phase aiguë d’un AVC : un outil rééducatif
Bornheim, Stephen ULiege; Croisier, Jean-Louis ULiege; Elkebir, Kamel Eddine ULiege et al

in Kinesitherapie, La Revue (2019, February), 19(206), 83

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See detailEntraînement du contrôle moteur lombopelvien chez le joueur de tennis élite
Grosdent, Stéphanie ULiege; Demoulin, Christophe ULiege; Tomasella, Marco ULiege et al

in Kinesitherapie, La Revue (2019, February), 19(206), 43-44

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See detailConceptual Design of a Variable Stiffness Mechanism in a Humanoid Ankle Using Parallel Redundant Actuation
Stoeffler, C.; Kumar, S.; Peters, H. et al

in IEEE-RAS International Conference on Humanoid Robots (2019, January), 2018-November

Future robots will rely more than today on high precision, better energy efficiency and safe handling (e.g. human-machine interaction). An inevitable step in the development of new robots is therefore the ... [more ▼]

Future robots will rely more than today on high precision, better energy efficiency and safe handling (e.g. human-machine interaction). An inevitable step in the development of new robots is therefore the improvement of existing mechanisms, since better sensors and algorithms do not satisfy the demands alone. During the last three decades, Parallel Redundant Mechanisms (PRM) came more into the focus of research, as they are advantageous in terms of singularity avoidance, fast movements and energy efficiency. Subsequently, yet another technology - the Variable Impedance Actuator (VIA) - emerged which proposes to change its inherent stiffness allowing an adaptation to its environment and to handle for example dynamic movements or shock absorptions. This work aims to create a new mechanism where a stiffness and position control for 2 degrees of freedom (DOF) is achieved by 3 actuators with flexible elements. It is thus a combination of the PRM and VIA, while taking advantage of both technologies but asking for a more sophisticated mathematical description. Practical implementation is intended for a humanoid ankle mechanism. Kinetostatic and stiffness models are derived and incorporated into the simulation of the mechanism. The simulations show that improvements in terms of singularity removal and dexterity are achieved. Furthermore, the adaptation of human like gait performances is presented. © 2018 IEEE. [less ▲]

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See detailMémoire, neuroimagerie fonctionnelle et maladie d'Alzheimer
Bastin, Christine ULiege

in Neurophysiologie Clinique (2019), 49(3), 198

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See detailENT Surgical Training in 2018: National Cross-sectional Study
ROGISTER, Florence ULiege; CAMBY, Séverine ULiege; LEFEBVRE, Philippe ULiege et al

in B-ENT (2019)

Introduction and Aim: This study aimed to draw up an inventory of the current practical training from the surgical trainees’ point of view, identifying strengths and gaps of current training and potential ... [more ▼]

Introduction and Aim: This study aimed to draw up an inventory of the current practical training from the surgical trainees’ point of view, identifying strengths and gaps of current training and potential tools to be developed. Material and Methods: We conducted a broad national survey among Belgian population within the North-part and South-part universities of the country. The questions included self-assessment, training objectives, training quality and training tools. Results: 35.7% of trainees evaluated their level of overall surgical competence at 3/5 compared to an ideal mastery. More than a half (55%) of trainees did not know the training objectives and 73% did not know the basic surgical procedures that a qualified ENT surgeon should be able to perform. The main mode of learning (41%) was the observation of a senior and repetition under supervision (companionship). The results showed mainly logistical and economic drawbacks, on which it seems possible to act using learning methods based on the implementation of organized training sessions, associated with different learning tools such as surgical and procedural simulation. Some of these are already available in our country but remain difficult to access or to develop. Conclusion: This study revealed a real demand and motivation from trainees and could serve as a basis to sketch a teaching scheme improving skills and confidence of future surgeons. Additional studies are needed to identify the most effective ways for implementing this type of teaching within the constraints of the surgical curriculum and teaching hospitals resources. [less ▲]

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See detailModification of potassium in dialysate: impact on per-dialytic plasma potassium concentrations and electrocardiograms.
DELANAYE, Pierre ULiege; Krzesinski, François; DUBOIS, Bernard ULiege et al

in Nephrology Dialysis Transplantation (2019)

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See detailCurrent practice and variability in micronutrient monitoring and administration: results of the Vita-Trace survey
Vankrunkelsven, W; Gunst, J; Amrein, K et al

in Critical Care (2019), 23(Suppl 2), 275

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See detailImpact of a Shift in Treatment Funding on a Multidisciplinary Sleep Clinic: a Cohort Study
VERMEIRE, Pierre ULiege; FANIELLE, Julien ULiege; BRUWIER, Annick ULiege et al

in B-ENT (2019)

Introduction and Aim: A shift in Obstructive Sleep Apnea (OSA) funding was implemented in Belgium on January 1, 2017. Funding was allowed for moderate to severe OSA and the rules shifted for treatments ... [more ▼]

Introduction and Aim: A shift in Obstructive Sleep Apnea (OSA) funding was implemented in Belgium on January 1, 2017. Funding was allowed for moderate to severe OSA and the rules shifted for treatments delivery and monitoring by authorised medical opinion. Multidisciplinary Sleep Clinics have long existed, bringing together sleep specialists, dentists, orthodontists and surgeons. We aimed to assess whether a shift in treatment funding was associated with a change in the multidisciplinary sleep practice. Material and Methods: Sample consisted of all patients discussed in the sleep multidisciplinary team meetings of the University Hospital of Liege from January 2016 to December 2018. Interrupted times series, Mann-Whitney U tests and descriptive statistics were produced. Results: There were no differences in patients age, male sex preponderance, body mass index, clinical presentation and level of obstruction. Baseline OSA severity was significantly lower (mean apnea-hypopnea index and mean oxygen desaturation index lowered respectively with p = 0.0189 and p = 0.0466) after the funding rules changed. Oral appliance and ENT surgery were more often offered after the shift in funding. Conclusion: Sleep multidisciplinary team meeting changed patient selection and management after the implementation of the new funding rules for OSA. The shift in funding often resulted in treatment options change, reaching more people and offering more options. [less ▲]

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See detailEffects of Rapid Maxillary Expansion on Respiratory Events in Children: Are we doing no Harm?
REMACLE, Sarah ULiege; HENDRIX, Charlotte ULiege; BRUWIER, Annick ULiege et al

in B-ENT (2019)

Introduction and Aim: Rapid maxillary expansion devices are used in children with upper maxillary transverse deficit and cross-bite. They were consistently shown to improve obstructive apnoea syndrome in ... [more ▼]

Introduction and Aim: Rapid maxillary expansion devices are used in children with upper maxillary transverse deficit and cross-bite. They were consistently shown to improve obstructive apnoea syndrome in children. However, the impact of the device in place into the child’s mouth has never been studied. The aim of our study was to quantify the effect of the device on respiratory events while in place. Secondary endpoints were to evaluate its impact on quality of life and on respiratory events after treatment. Material and Methods: 12 consecutive children with maxillary cross-bite were prospectively included in this cohort study. Respiratory events were recorded before, during and after rapid maxillary expansion using a validated type 3 polygraphy including jaw movements. Subjective outcomes were evaluated using Obstructive Sleep Apnea (OSA)-18 quality-of-life questionnaire (OSA-18). Maxillary width and 16/26 distance were evaluated before and after rapid maxillary expansion on anterior radiography. Results: Estimated apnea hypopnea index increased from 2.67/h (±1.31/h) to 2.9/h (±2.4/h) with the device in place. Respiratory effort characterized by jaw motion > 0.4mm during the respiratory cycle increased from 7.58% (±10.01%) to 16.05% (±15.53%). Sleep-related breathing impairment was confirmed by parents’ questionnaires. Conclusion: While rapid maxillary expansion is an effective treatment for obstructive apnea syndrome in children, our study suggested a transient worsening of sleep breathing while the device is in place. It may be related to an incorrect tongue position and/or to the crowding of the device into the mouth. [less ▲]

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See detailInvestigating the Impact of Urban Layout Geometry on Urban Flooding
Mustafa, Ahmed Mohamed El Saeid ULiege; Zhang, Xiao Wei; Aliaga, Daniel G. et al

in Proceedings of GEOProcessing 2019 (2019)

In this paper, we use a procedural generation system to design urban layouts that passively reduce water depth during urban floods. The tool enables designing cities that passively lower flood depth ... [more ▼]

In this paper, we use a procedural generation system to design urban layouts that passively reduce water depth during urban floods. The tool enables designing cities that passively lower flood depth everywhere or in chosen key areas. Our approach integrates a porosity-based hydraulic model and a parameterized urban generation system with an optimization engine so as to find the least cost modification to an initial urban layout. In order to investigate the relationship between urban layout design parameters and flood inundation depth, correlation coefficient method is used. This paper concludes that the most influential urban layout parameters are average road length and the mean parcel area. Keywords-inverse procedural modeling; urban layout design; porosity-based hydraulic model; Pearson correlation; urban flooding. [less ▲]

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See detailWeathering pattern of Messinian lithothamnium limestones: implication about paleoclimatic conditions
Moulana, Meriem Lina ULiege; El Ouahabi, Meriam ULiege; Boulvain, Frédéric ULiege et al

in Geologica Belgica (2019)

Limestones are prevalent in Algeria. These formations since their deposition have been affected by a range of weathering, dissolution and recrystallization processes dependant of the paleoclimatic ... [more ▼]

Limestones are prevalent in Algeria. These formations since their deposition have been affected by a range of weathering, dissolution and recrystallization processes dependant of the paleoclimatic conditions they sustained. These transformations also affect the potential hazard that these karstic terrains represent. We focus here on the Boukadir Region situated at the foot of the Ouarsenis Mountain (Fig. 1). The region comprises the Ouarsenis northern piedmont composed of ~15o north dipping lithothamnium limestones of the Messinian period that rest unconformably upon blue marls of the upper Miocene, and to the south the E-W striking lower Chlef Basin filled by Plio-Quaternary sediments and flooded by the Chlef River. The lithothamnium carbonates rocks form a major deep aquifer in the Basin. The Basin is crossed along its southern edge by the Relizane strike-slip fault. In June 1988, there was a large collapse sinkhole of 60 m in diameter and 35 m of deep that occurred along the national road RN4 near the southern edge of the basin (LCTP, 1989). Drilling shows that sinkhole can be associated to lithothamnium limestones that were covered by more than 61 m of sediments at that location. No other sinkhole formed since this accident. In this study we investigate the weathering pattern of the lithothamnium limestones to unravel the likelihood of formation of large sinkholes in this formation. Boreholes and quarries show that the Messinian Calcareous limestones of the Boukadir region are deeply weathered and partly recrystallized calcareous rocks; the weathering affects its entire thickness reaching a maximum of 200 m. This weathering pattern is not visible a few kilometres more to the east, in limestones having a similar origin. To unravel the specific paleoclimatic conditions that these limestones sustained, we combine field work and on selected samples, petrographic thin section and mineralogical (XRD) analysis and SEM observations. Field work in quarries and in the wadi shows that the lithothamnium limestones are composed of altering sandstone rich beds with a calcareous cement and bioconstructions rich beds. .. [less ▲]

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See detailAutomatic design of flood-resilient urban layouts
Dewals, Benjamin ULiege; Mustafa, Ahmed Mohamed El Saeid ULiege; Bruwier, Martin ULiege et al

in Geophysical Research Abstracts (2019)

Urban planning is central to flood risk prevention. Flood-sensitive urban planning pursues two goals: reducing flood exposure and vulnerability [1]; but also addressing the influence of urban ... [more ▼]

Urban planning is central to flood risk prevention. Flood-sensitive urban planning pursues two goals: reducing flood exposure and vulnerability [1]; but also addressing the influence of urban characteristics on flood flow severity (flow depths and velocities) [2]. Focusing on the latter, we present here a unique software which automatically optimizes the geometry of urban layouts to enhance flood resilience [3]. The optimized parameters describe the arrangement of the road network, the blocks, the parcels, and the buildings. The proposed approach is particularly innovative since, so far, such automatic urban design tools were developed only for totally different objectives (e.g. optimizing sun exposure or distance to parks); but not in the context of flood risk management. Our automatic urban design system consists of three components: (i) a procedural urban model, (ii) a surrogate for a hydraulic model and (iii) an optimization engine. • Starting from a set of input parameters pi (typical road length, width, curvature …) the procedural urban model generates urban layouts which mimic fairly realistically real-world urban patterns [3]. • To achieve interactive feedback (i.e. getting the results within a few seconds), the system uses a neural network (NN) to approximate the relationship between urban layout and flood flow characteristics. The NN was trained using a relatively fast 2D porosity-based hydraulic model [4], which in turn was calibrated against a detailed shallow-water model [2]. • A Markov Chain Monte Carlo optimization is used to adjust iteratively the procedural model parameters pi so as to yield the desired urban layout. The system was tested for optimizing the layout of an urban district of 1 km by 1 km subject to river flooding. The system runs about one minute to find the optimal urban layout. The system tends to improve the flow conveyance through the urban area by increasing the voids in-between the buildings (e.g., increase road width) and by promoting a more “fragmented” urban pattern (e.g., decrease road length). The optimization reduces the flood water depths in the district by up to 20 to 25%. Several real-world examples showcase the operationality of the system for improving flood resilience through flood-sensitive urban design [3]. In practice, such an interactive digital tool can valuably assist urban planners and architects to assess the implications of various design decisions on flooding and end up with improved flood-sensitive urban layouts. The approach should be further developed to accommodate more diverse flooding scenarios (e.g. pluvial floods, coastal floods, etc.). References [1] Mustafa, A. et al. (2018). Effects of spatial planning on future flood risks in urban environments. J. Environ. Manage. 225, 193–204. [2] Bruwier, M. et al. (2018). Influence of urban pattern on inundation flow in floodplains of lowland rivers. Sci. Total Environ. 622-623, 446–458. [3] Mustafa, A. et al. (2019). Procedural Generation of Flood-Sensitive Urban Layouts. Environ Plan B Urban Anal City Sci. In press. [4] Bruwier, M. et al. (2017). Shallow-water models with anisotropic porosity and merging for flood modelling on Cartesian grids. J. Hydrol. 554, C, 693–709. [less ▲]

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See detailTracking magma movements in the Virunga volcanic province using seismic Amplitude Ratio Analysis (SARA)
Subira, Josué; Caudron, Corentin; Hubert, Aurelia ULiege et al

in Geologica Belgica (2019)

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See detailSedimentary evolution of the Sagara coastal area in Japan and its potential to preserve extreme wave deposits
Kempf, Philipp; Garrett, Ed; Fujuwara, Osamu et al

in Geologica Belgica (2019)

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See detailFirst results from the KinAero MAXDOAS instrument
Pinardi, Gaia; Alexis, Merlaud; Martina, Friedrich et al

in Geophysical Research Abstracts (2019), Vol. 21(EGU2019-15792-1, 2019), 1

As part of an ongoing collaboration with the University of Kinshasa (RDC), we have recently developed a compact low-cost MAXDOAS instrument (KinAero) in view of deploying it at Kinshasa for long term ... [more ▼]

As part of an ongoing collaboration with the University of Kinshasa (RDC), we have recently developed a compact low-cost MAXDOAS instrument (KinAero) in view of deploying it at Kinshasa for long term monitoring of atmospheric pollutants such as NO2 and HCHO. We present the KinAero system, which consists in a compact grating spectrometer from the Avantes company coupled by optical fiber to an elevation scanning device operating in one fixed azimuthal direction. The spectral range covers the wavelengths from 290-550 nm with a resolution of 0.7 nm FWHM. We show characterization results of KinAero from the lab (detector linearity, signal-to-noise, pointing accuracy,...) and assess the overall quality of the NO2 and O4 slant column measurements based on comparisons with the BIRA-IASB NDACC-certified MAXDOAS instrument in Uccle. Between September and December 2018, KinAero was installed on the ICOS observation tower in Vielsalm (50.31◦N, 6◦E, 445 m.a.s.l), in a forest area. These measurements were performed as part of the BelAIR-Silva campaign, which provided a good opportunity to test the instrument in the field for a period of several months. The instrument was found to be stable during the full duration of the campaign. Using retrieval tools developed as part of the ESA FRM4DOAS project, we derived time-series of NO2 and HCHO column and profile measurements, which are applied to comparisons with the TROPOMI/S5P satellite instrument. [less ▲]

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See detailRecurrence in multidimensional words
Charlier, Emilie ULiege; Puzynina, Svetlana; Vandomme, Elise ULiege

in Lecture Notes in Computer Science (2019), 11417

In this paper we study various modifications of the notion of uniform recurrence in multidimensional infinite words. A d-dimensional infinite word is said to be uniformly recurrent if for each prefix ... [more ▼]

In this paper we study various modifications of the notion of uniform recurrence in multidimensional infinite words. A d-dimensional infinite word is said to be uniformly recurrent if for each prefix, there exists a fixed size such that each block of this size contains the prefix. We introduce and study a new notion of uniform recurrence of multidimensional infinite words: for each rational slope, each rectangular prefix must occur along this slope with bounded gaps. Such words are called uniformly recurrent along all directions. We provide several constructions of multidimensional infinite words satisfying this condition, and more generally, a series of three conditions on recurrence. We study general properties of these new notions and in particular we study the strong uniform recurrence of fixed points of square morphisms. [less ▲]

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See detailKinsbourne syndrome as complication of a Mycoplasma pneumoniae infection
ADOUANE, Linda ULiege; Hoyoux, Marie ULiege; FRERE, Julie ULiege et al

in Belgian Journal of Paediatrics (2019), 21

Few cases of Kinsbourne syndrome secondary to Mycoplasma pneumoniae infection are described in present literature. Here, we present the rare case of a young boy who spontaneously demonstrated a favorable ... [more ▼]

Few cases of Kinsbourne syndrome secondary to Mycoplasma pneumoniae infection are described in present literature. Here, we present the rare case of a young boy who spontaneously demonstrated a favorable evolution without immunomodulatory treatment. [less ▲]

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See detailIntérêt des inhibiteurs SGLT-2 dans le diabète de type 1
PHILIPS, Jean-Christophe ULiege; PAQUOT, Nicolas ULiege; SCHEEN, André ULiege

in Diabetes and Metabolism (2019)

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See detailIntérêt d'un traitement local dans la neuropathie diabétique douloureuse
PHILIPS, Jean-Christophe ULiege

in Diabetes and Metabolism Journal (2019)

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See detailRecherche de facteurs prédictifs de recourir à l’insulinothérapie dans le diabète gestationnel
PHILIPS, Jean-Christophe ULiege; RADERMECKER, Régis ULiege; Rodari, Arthur et al

in Diabetes and Metabolism (2019)

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See detailImpact of the creatinine-based equations used on the chronic kidney disease classification in a large laboratory database
masson, grégoire; VRANKEN, Laura ULiege; KRZESINSKI, Jean-Marie ULiege et al

in Nephrology Dialysis Transplantation (2019)

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See detailMixture model in high-order statistics for peak factor estimation on low-rise building
Rigo, François ULiege; Andrianne, Thomas ULiege; Denoël, Vincent ULiege

in Proceedings of the XV Conference of the Italian Association for Wind Engineering (2018, December 10)

To design reliable structures, extreme pressures and peak factors are required. In many applications of Wind Engineering, their statistical analysis has to be performed taking into account the non ... [more ▼]

To design reliable structures, extreme pressures and peak factors are required. In many applications of Wind Engineering, their statistical analysis has to be performed taking into account the non-Gaussianity of the wind pressures. With the increasing precision and sampling frequency of pressure sensors, large short and local peak events are more usually captured. Their relevance is naturally questioned in the context of a structural design. Furthermore, the increasing computational power allows for accumulation and analysis of larger data sets revealing the detailed nature of wind flows around bluff bodies. In particular, in the shear layers and where local vortices form, it is commonly admitted that the Probability Density Function (PDF) of measured pressures might exhibit two or more significant components. These mixed flows can be modelled with mixture models [Cook (2016)]. Whenever several processes coexist, and when one of them is leading in the tail of the statistical distribution, as will be seen next in the context of corner vortices over a flat roof, it is natural to construct the extreme value model with this leading process and not with the mixed observed pressures. It is therefore important to separate the different processes that can be observed in the pressure histories. Once this is done, specific analytical formulations of non-Gaussian peak factors can be used to evaluate the statistics of extreme values [Kareem and Zhao (1994), Chen (2009)]. The separation of mixed processes is usually done by means of the PDF of the signals [Cook (2016)]. This information is of course essential to perform an accurate decomposition but it might be facilitated by considering higher rank information like auto-correlations and higher correlations like the triple or quadruple correlation. Indeed, the two phenomena that need to be separated and identified might be characterized by significantly different timescales, which are not reflected in the PDF. In this paper, the large negative pressures measured on a flat roof are analyzed and decomposed into two elementary processes, namely, the flapping corner vortex and the turbulent flow detaching from the sharp upstream edge. The full paper will finally show that an accurate decomposition of the recorded pressures into their underlying modes provides a more meaningful evaluation of the extreme pressures. [less ▲]

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See detailL’analyse des acides gras érythrocytaires maternels en début de grossesse révèle un faible index oméga-3
Hoge, Axelle ULiege; Bernardy, Florence; Donneau, Anne-Françoise ULiege et al

in Nutrition Clinique et Metabolisme (2018, December), 32(4),

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See detailLa gastronomie comme patrimoine culturel. Valorisation d'un terroir: l'Ogliastra (Italie) et le Pays de Herve (Belgique)
Aresu, Anna ULiege

in Revue Internationale d'Études en Langues Modernes Appliquées (2018, December), II

The cultural heritage of our food production is very important for our present and future time. Gastronomy is a key to discover places where we find the identity of people, their culture, their traditions ... [more ▼]

The cultural heritage of our food production is very important for our present and future time. Gastronomy is a key to discover places where we find the identity of people, their culture, their traditions, their history. We must pay attention to this heritage and try to defend it, to saveguard and promote it for current and next generations all over the world. The organisation of a cultural project related to gastronomy, which concerns small regions, in this case Ogliastra (Sardinia - Italy) and the Pays de Herve (Wallonia - Belgium) can be applied to a large territory and to other areas of our planet through the promotion and the valorisation of the agricultural produts. Even if these terroirs have two different realities of agri-food production, this heritage belongs to the economic and social reality of today's small producers, their survival in an increasingly globalized market, with a place in short food supply chain, as well as local and regional agriculture. [less ▲]

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See detailEntre authenticité et extrapolation : l’interprétation des œuvres de Nicolas Schöffer
D'Haenens, Manon ULiege

in CeROArt: Conservation, Exposition, Restauration d'Objets d'Art (2018, December), HS

This paper presents a discussion about the interpretation of contemporary artworks, with case studies of Nicolas Schöffer. It is based on the definition of conservation as interpretation, a decision ... [more ▼]

This paper presents a discussion about the interpretation of contemporary artworks, with case studies of Nicolas Schöffer. It is based on the definition of conservation as interpretation, a decision process in order to transmit artworks. The concepts of authenticity, intentionality and extrapolation are confronted to characteristic case studies from contemporary artworks. [less ▲]

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See detailGrowth hormone (GH) deficient mice with GHRH ablation are severely deficient in vaccine and immune responses against Streptococcus pneumoniae
Farhat, Khalil; Bodart, Gwennaëlle ULiege; Moutschen, Michel ULiege et al

in Acta Clinica Belgica (2018, December), 73(6 (Suppl.2)),

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See detailThyroid dysfunction after Alemtuzumab treatment for multiple sclerosis : a report of four cases
Daniel, Sara ULiege; HANSEN, Isabelle ULiege; Dive, Dominique ULiege et al

in Acta Clinica Belgica (2018, December), 73(2),

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See detailLow-temperature Packaging Methods as a Key Enablers for Microsystems Assembly and Integration
Stoukatch, Serguei ULiege; Dupont, François ULiege; Kraft, Michael

in IEEE Xplore (2018, November 19)

The paper reports on assembly and integration of MS (microsystems) into fully functional system. We show that among varieties of assembly techniques and methods commonly used for IC, some can be ... [more ▼]

The paper reports on assembly and integration of MS (microsystems) into fully functional system. We show that among varieties of assembly techniques and methods commonly used for IC, some can be successfully used also for the assembly of microsystems. MS are specifically sensitive to thermal exposure that can occur during the assembly and integration process. [less ▲]

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See detailMalaria risk assessment at local level using satellite imagery and BRT in the Peruvian Amazon
Solano-Villarreal, Elisa; Valdivia, Walter; Linard, Catherine ULiege et al

in Archives of Public Health (2018, November 13), 77 (suppl 1)(7),

Background: Malaria in Loreto department remains a public health problem, accounting for more than 90% of reported cases in Peru. This is the first study in the Peruvian Amazon aimed at assessing the risk ... [more ▼]

Background: Malaria in Loreto department remains a public health problem, accounting for more than 90% of reported cases in Peru. This is the first study in the Peruvian Amazon aimed at assessing the risk of malaria transmission using satellite imagery and Boosted Regression Trees (BRT). Methods: Villages with at least one malaria case between 2010 and 2015 from the routine surveillance data in Loreto were georeferenced and their cases aggregated by year and species. Social and environmental variables were derived from Landsat satellite imagery and other spatial data, then included as explanatory variables into a crossvalidated Poisson BRT model for malaria incidence at the local level. Time-dependent explanatory variables included forest coverage (FC, %), annual forest loss (FL,%), cumulative annual rainfall (CAR, mm), annual-mean land surface temperature (LST, oC), normalised difference vegetation index (NDVI), and normalised difference water index (NDWI). Other variables were Euclidean shortest distance to rivers (SDR, meters), time to major populated villages/towns (TPV, minutes), and night-time lights (NTL, mean value 2010-2013) as proxy of population density. BRT accounts for nonlinearities and interactions between factors with high predictive accuracy for disease risk mapping. Results: A total of 1524 villages were included in the analysis (70% of total Loreto’s villages). More than 90% of relative influence in the overall malaria incidence was explained by five variables: NTL (67.8%), TPV (8.1%), FC (6.5%), CAR (5%) and SDR (4.6%). The analysis by species showed a higher influence of environmental variables (CAR, LST, NDVI and NDWI) for P. falciparum (18.4%) than for P. vivax incidence (9.7%). Malaria risk maps were generated based on model predictions taking into account the relative influence of variables. Conclusions: Remotely sensed data analysed using BRT allowed for maps delimiting areas of high malaria risk in Loreto. These maps will help malaria stakeholders to prioritise areas for control interventions. [less ▲]

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See detailThe use of Platelet-Rich Plasma (PRP) to treat chronic tendinopathies: a technical analysis
Kaux, Jean-François ULiege; Emonds-Alt, Thibault ULiege

in British Journal of Sports Medicine (2018, November), 52(Suppl 3), 1

Platelet-rich plasma (PRP) is blood plasma with a high concentration of autologous platelets which constitute an immense reservoir of growth factors. The clinical use of PRP is widespread in various ... [more ▼]

Platelet-rich plasma (PRP) is blood plasma with a high concentration of autologous platelets which constitute an immense reservoir of growth factors. The clinical use of PRP is widespread in various medical applications. Although highly popular with athletes, the use of PRP for the treatment of tendinopathies remains scientifically controversial, particularly due to the diversity of products that go by the name of ‘PRP.’ To optimize its use, it is important to look at the various stages of obtaining PRP. In this literature review, we take a closer look at eight parameters which may influence the quality of PRP: 1. anticoagulants used to preserve the best platelet function, 2. the speed of centrifugation used to extract the platelets, 3. the platelet concentrations obtained, 4. the impact of the concentration of red and white blood cells on PRP actions, 5. platelet activators encouraging platelet degranulation and, hence, the release of growth factors, and 6. the use or nonuse of local anesthetics when carrying out infiltration. In addition to these parameters, it may be interesting to analyze other variables such as 7. the use of ultrasound guidance during the injection with a view to determining the influence they have on potential recovery. In conclusion, there is a lack of standardization in PRP preparation technique for tendinopathies. However, it appears that the use of a platelet concentration lower than 5 times the baseline and avoidance of leukocytes should be preferred. [less ▲]

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See detailHet citizen-science project rond de Hobokense mammoet
Stein, Koen ULiege; Jentgen, Benjamin ULiege; Hellemond, Anthonie et al

in Belgische Vereniging voor Paleontologie & Werkgroep Pleistocene Zoogdieren (2018, November)

The Hoboken mammoth is a Belgian patrimonal piece of natural history that was mostly ignored since its discovery in 1865. The citizen-science program of the Flemish government was deemed ideal to study ... [more ▼]

The Hoboken mammoth is a Belgian patrimonal piece of natural history that was mostly ignored since its discovery in 1865. The citizen-science program of the Flemish government was deemed ideal to study the skeleton and provide a new reconstruction, find out its geological and individual age and get an insight into its state of preservation. Such a paleobiological study is crucial for a better understanding of the evolution of the Hoboken landscape and the Flemish Valley during the last 30.000 years. By actively involving citizen scientists (mostly volunteers, amateur paleontologists and schools) into the different steps of this multi-disciplinary investigation, the participants can obtain a thorough insight into the fundamental values of the STEM disciplines (science, technology, engineering and mathematics). The ultimate goal is to set-up a permanent exhibit in Hoboken with the reconstruction of the complete skeleton combined with the results of additional research on this unique Belgian mammoth. Unfortunately the project was not funded in the 2018 application round, but the authors continue searching for alternative funding. [less ▲]

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See detailDéveloppement d’un questionnaire permettant d’identifier la présence de croyances délétères chez les patients lombalgiques
Demoulin, Christophe ULiege; SALAMUN, Irène ULiege; Bertrand, J. et al

in Revue du Rhumatisme (2018, November), 85(Supplément 1), 165-166

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See detailComparaison de l’intérêt de différentes techniques d’entraînement sensoriel chez des patients douloureux chroniques (lombalgie, cervicalgie et fibromyalgie)
Demoulin, Christophe ULiege; Geoffroy, M.; Schneider, E. et al

in Revue du Rhumatisme (2018, November), 85(Supplément 1), 105-106

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See detailLe peptide chimérique synthétique P7 réduit la douleur et protège le cartilage chez le rat souffrant d’arthrose après méniscectomie partielle et section du ligament croisé
Montjean, R; Escaich, S; Vêtu, C et al

in Revue du Rhumatisme (2018, November), 85S

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See detailLe syndécan-4 est un marqueur de l’hypertrophie des chondrocytes du genou arthrosique
Sanchez, Christelle ULiege; Lambert, Cécile ULiege; Dubuc, JE et al

in Revue du Rhumatisme (2018, November), 85S

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See detailMuscle OXPHOS capacities in endurance horses predict racing performance
Votion, Dominique ULiege; Fraipont, Audrey ULiege; Robert, C. et al

in Comparative Exercise Physiology (2018, November), 14

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See detailNew concepts in liver regeneration mechanisms in human severe alcoholic steatohepatitis.
Lejeune, A; Starkel, P; Louvet, A et al

in Hepatology (2018, October 18), 68(S1), 1378

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See detailSpatio-temporal reasoning in CIDOC CRM: an hybrid ontology with GeoSPARQL and OWL-Time
Nys, Gilles-Antoine ULiege; Van Ruymbeke, Muriel ULiege; Billen, Roland ULiege

in CEUR Workshop Proceedings (2018, October 13), 2230

Semantic description of cultural heritage information is already widely structured through CIDOC CRM and its different extensions. This shared understanding of cultural heritage information has already ... [more ▼]

Semantic description of cultural heritage information is already widely structured through CIDOC CRM and its different extensions. This shared understanding of cultural heritage information has already proved its usefulness. Until now, despite its spatial and temporal data management proposition, lack standardization limited the possibilities in terms of reasoning and workability. This paper proposes to increase the potentiality offered by the current scheme by including GeoSPARQL and OWL-Time in the framework. The result, as hybrid ontology, allows concurrent spatial and temporal handling. These are used to provide a near-full data management for complex spatio-temporal reasoning and querying through SPARQL queries. Example queries depicting the strength of the approach and allowing knowledge discovery in huge archaeological datasets illustrate its benefits [less ▲]

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See detailEffect of antimicrobial drug on lung microbiota in healthy dogs.
Fastrès, Aline ULiege; Vangrinsven, Emilie ULiege; Tutunaru, Alexandru-Cosmin ULiege et al

in Journal of Veterinary Internal Medicine (2018, October 12)

In human and dogs, baseline differences in lung microbiota (LM) have been associated with important clinical features in chronic lung diseases (CLD) and there is growing evidence that an altered LM ... [more ▼]

In human and dogs, baseline differences in lung microbiota (LM) have been associated with important clinical features in chronic lung diseases (CLD) and there is growing evidence that an altered LM contributes to disease pathogenesis. The common use of antibiotic drugs throughout the management of CLD likely represents a major confounding factor in the study of the LM. However, the effect of antibiotic treatment on the LM in healthy individuals has not been specifically investigated yet. The aim of the present study was to assess the short and medium-term effect of an oral treatment with a large spectrum antimicrobial drug on the LM in healthy dogs. Six healthy experimental beagle dogs were included. Amoxycillin/clavulanic acid (AC) was administered at a dose of 20 mg/kg twice daily for 10 days. In each dog, bronchoalveolar lavage fluid (BALF) was collected at 3 different timepoints: before administration of AC (J0) and immediately (J10) as well as 16 days (J26) after interruption of AC. In each BALF, total and differentiated cell counts were obtained and metagenetic analyses were performed on the V1-V3 hypervariable region of 16S rDNA after total bacterial DNA extraction and sequencing on a MiSeq Illumina sequencer. Taxonomical assignation and microbiota community analysis were done with MOTHUR V1.35 with an OTU clustering distance of 0.03. Statistical comparisons between events for microbiota community and BALF cell counts were made using Friedman test and post-hoc t-tests with Bonferroni correction. Statistical differences in bacterial population relative abundance between timepoints were assessed using a mixed linear model with FDR correction for multiple comparisons. Administration of AC did not induce significant changes in BALF cellular counts and had no effect on the richness, evenness and alpha diversity. Bacteroidetes and Proteobacteria abundance increased from J0 to J10 (mean: 12.0 to 24.1, and 12.3 to 26.2%, respectively; p<0.001) and decreased at J26 (13.1 and 9.3%; p<0.001). Firmicutes abundance decreased from J0 to J10 (45.6 to 18.3%; p<0.001) and increased at J26 (28.8%; p<0.001). Actinobacteria abundance increased at J26, compared with J0 and J10 (43.7 compared with 23.2 and 23.5% respectively; p<0.001). We failed to show significant differences between timepoints at the level of genera and species. In conclusion, in healthy dog, oral administration of a commonly used large spectrum antimicrobial drug induces significant changes in microbial population abundance at the phyla level. Most but not all of these changes normalize within 2 weeks after discontinuation of the drug. [less ▲]

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See detailComet 66P/du Toit: A Near Earth Main Belt Comet?
Yang, Bin; Opitom, Cyrielle; Jehin, Emmanuel ULiege et al

in Bulletin of the American Astronomical Society (2018, October 01), 50

We obtained medium-resolution and high-resolution spectra of the near-Earth Jupiter family comet (JFC) 66P/du Toit from 300 to 2500 nm with X-shooter/VLT and UVES/VLT on 2018 July 01, 07 and 13 ... [more ▼]

We obtained medium-resolution and high-resolution spectra of the near-Earth Jupiter family comet (JFC) 66P/du Toit from 300 to 2500 nm with X-shooter/VLT and UVES/VLT on 2018 July 01, 07 and 13, respectively. In addition, we obtained a series of narrow-band images of 66P between 2018 May and July with TRAPPIST-South. Comet 66P is one of the weakly active JFCs that were identified by Fernandez & Sosa (2015) as having the highest probability of coming from the Main Belt. Our main goal is to investigate the composition of this comet via measuring the gaseous species in the UV and visible and to study its dust properties via measuring the continuum over a broad wavelength range. Additionally, we aim to measure the ortho-to-para abundance ratio of NH2 to constrain the formation conditions of this comet. I will present our spectroscopic observations as well as the photometric observations of 66P. I will discuss whether this comet shows any clear difference in terms of its volatile profile or its dust profile compared to other typical JFCs. [less ▲]

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See detailA high resolution spetrum of comet C/2016 R2 (PanSTARRS) with the ESO VLT
Jehin, Emmanuel ULiege; Opitom, Cyrielle; Hutsemekers, Damien ULiege et al

in Bulletin of the American Astronomical Society (2018, October 01), 50

The returning long period comet C/2016 R2 (PanSTARRS) was discovered on September 7, 2016 at 6.3 au from the Sun. While it was already showing a 20" coma at this large distance (Weryk and Wainscoat 2016 ... [more ▼]

The returning long period comet C/2016 R2 (PanSTARRS) was discovered on September 7, 2016 at 6.3 au from the Sun. While it was already showing a 20" coma at this large distance (Weryk and Wainscoat 2016), it is only in December 2017 that it was found that this comet had a very unusual composition. From radio observations the comet appeared to be very rich in CO and very poor in HCN (Wierzchos and Womack 2018) and its optical spectrum was dominated by CO[SUP]+[/SUP] and more surprisingly N[SUB]2[/SUB][SUP]+[/SUP] emission bands (Cochran and McKay 2018), while most of the emission bands usually detected in the optical spectrum of comets were not detected. In order to investigate in detail its coma in the optical, we obtained a total of 6 hours of Director Discretionary Time on C/2016 R2 with UVES, the high resolution optical spectrograph of the ESO Very Large Telescope, between February 11 and 16, 2018. We used two different settings to optimally cover the whole optical spectrum (326-1060 nm) with a resolving power of 80.000. We report on those observations. We detect strong emissions of the ions CO[SUP]+[/SUP] and N[SUB]2[/SUB][SUP]+[/SUP], and also several CO[SUB]2[/SUB][SUP]+ [/SUP]bands, but no H[SUB]2[/SUB]O[SUP]+[/SUP] . We detect emission lines of the radicals CN, C[SUB]2[/SUB] and C[SUB]3[/SUB] but they are very weak. We computed from these spectra the N[SUB]2[/SUB][SUP]+[/SUP] / CO[SUP]+[/SUP] / CO[SUB]2[/SUB][SUP]+[/SUP] ratios in the coma of the comet which put some constraints on the comet formation models, and compared those values to other comets. The forbidden oxygen [OI] lines are detected, allowing to measure the ratio between the green line and the red doublet which provides a way to determine the abundance of CO and CO[SUB]2[/SUB] relative to H[SUB]2[/SUB]O. For the first time we report the detection of the nitrogen [NI] forbidden doublet at 5197.9 and 5200.2 Å in the coma of a comet, confirming the high abundance of nitrogen in this comet. Interestingly we also detect a line at 9850 Å which could be one of the carbon [CI] forbidden lines but we do not detect the other line of the doublet at 9823 Å. Because of the strong N[SUB]2[/SUB][SUP]+[/SUP] emissions, it was also a unique opportunity to measure the [SUP]14[/SUP]N/[SUP]15[/SUP]N isotopic ratio directly in N[SUB]2[/SUB], the main nitrogen reservoir in the solar nebula. [less ▲]

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See detailA realistic mixture of Persistent Organic Pollutants (POPs) reveals possible synergism to inhibit the transactivation activities of the rat Aryl hydrocarbon Receptor (rAhR) in vitro
Doan Thi Que, ULiege; Muller, Marc ULiege; Berntsen, HF et al

in Toxicology Letters (2018, October 01)

While organisms are exposed to mixtures of persistent organic pollutants (POPs), scientific studies usually focus on the toxicity of a single compound at a time and few have addressed the mixture effect ... [more ▼]

While organisms are exposed to mixtures of persistent organic pollutants (POPs), scientific studies usually focus on the toxicity of a single compound at a time and few have addressed the mixture effect. This study aims to determine how a realistic mixture of POPs can affect transactivation of the rat Aryl hydrocarbon Receptor (rAhR) in vitro. Luciferase reporter Dioxin responsive rat hepatoma cell lines (DR-H4IIE) were used to screen both rAhR agonistic and antagonistic activities of 29 compounds: six perfluorinated (PFAA), seven brominated (Br), and 16 chlorinated (Cl) compounds (seven polychlorinated biphenyls (PCBs) and nine organochlorine pesticides) listed as POPs under the 2001 Stockholm Convention. Only 5 (2 Cl and 3 Br) out of the 29 compounds presented rAhR agonistic activities while 16 (13 Cl and 3 Br) were rAhR antagonists. No effect was observed for PFAAs. To test possible interactions between these compounds, a mixture of these 29 POPs and six sub-mixtures (PFAA, Br, Cl, Cl + Br, Cl + PFAA and Br + PFAA), prepared based on the respective concentrations found in Scandinavian human blood with a normal daily intake, were tested for the same activities. Not surprisingly, POP mixture also displayed a rAhR antagonistic activity (IC50 = 371 ± 52 times the blood level) with the lowest effective concentration found at 75-time blood level. This level could be plausibly reached in humans after a food contamination incident or in highly exposed sub-populations. Testing the sub-mixtures showed that the Cl mixture is responsible for the antagonism of the POP mixture, contributing to 80% of the POP response. When DR-H4IIE cells were exposed to the Cl + PFAA mixture, the antagonist level was the same as the response of the POP mixture. This indicates that PFAAs are probably non-specific rAhR antagonists as they did not induce any antagonist response when tested alone. The IC50 of the Cl mixture calculated from the measured IC50 of all 13 active chlorinated compounds, using an additive model, was about the same as the measured IC50, 1.9 M and 2.3 M, respectively. This suggests that these compounds act additively in the Cl mixture. In contrast, the calculated and measured IC50 for the total POP mixture were 22 M and 43.2 M, respectively, along with non-specific rAhR antagonism of PFAA mixture, indicating a possible synergistic effect. [less ▲]

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See detailTechnology and aging : new opportunities for a better life
PETERMANS, Jean ULiege; Piccard, Sébastien ULiege; Boulanger, G

in European Geriatric Medicine (2018, October), 9(supp1),

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See detailTreating severely brain-injured patients with apomorphine: study protocol for a double blind randomized placebo-controlled trial using behavioral and neuroimaging assessments
Sanz, Leandro ULiege; Lejeune, Nicolas; Thibaut, Aurore ULiege et al

in Frontiers in Neuroscience (2018, October)

Background: Patients who survive severe brain injury may develop chronic disorders of consciousness. Treating these patients to improve recovery is extremely challenging because of the absence of ... [more ▼]

Background: Patients who survive severe brain injury may develop chronic disorders of consciousness. Treating these patients to improve recovery is extremely challenging because of the absence of international guidelines and scarce therapeutic options (Schnakers and Monti, 2017). Among pharmacological treatments, apomorphine, a potent direct non-specific dopamine agonist with a high affinity for D2 receptors, has exhibited promising behavioral effects and safety of use in small-sample pilot studies (Fridman et al., 2009, 2010). However, despite the improvement compared to historical data, the lack of a control group could not eliminate the possibility that the effect was a result of spontaneous recovery, and the true efficacy of apomorphine for the recovery of consciousness remains unclear (Gosseries et al., 2014). In addition, the underlying neural mechanisms of this treatment are still unknown. An upregulation of central thalamic activity through a modulation of the anterior forebrain mesocircuit has been proposed as a possible explanation (Schiff, 2010a, 2010b) but the absence of neuroimaging and neurophysiological data prevent definitive confirmation. This clinical trial aims to 1) verify and quantify the efficacy of apomorphine subcutaneous infusion in patients with disorders of consciousness, 2) better identify the rate and the phenotype of responders to treatment, 3) evaluate tolerance and side effects occurrence in this specific patient population and 4) investigate the neural networks underlying its modulating action on consciousness using multimodal outcome measurements. Methods/design: This study is a prospective double-blind randomized placebo-controlled trial. Forty-eight patients diagnosed with disorders of consciousness (i.e., unresponsive wakefulness syndrome and minimally conscious state) will be randomized to receive a 30-day regimen of either apomorphine hydrochloride or placebo via daily 12-hour subcutaneous infusions. Patients will be monitored at baseline 30 days before initiation of therapy, during treatment and for 30 days after treatment washout, followed by a two-year remote follow-up. In an initial study phase, up to six patients will be treated in an open-label fashion. Behavioral outcome measures will include weekly assessments using standardized scales such as the Coma Recovery Scale – Revised (CRS-R) (Giacino et al., 2004) and the Nociception Coma Scale – Revised (NCS-R) (Chatelle et al., 2012) during the inpatient phase. Tolerance and safety of use will be monitored using a specifically designed Adverse Events Questionnaire filled weekly by the referent physician, from treatment initiation to the end of the inpatient phase. Long-term behavioral follow-up will be performed at 6, 12 and 24 months post-treatment by telephone interview using the Glasgow Outcome Scale – Extended (GOS-E) (Levin et al., 2001) as well as phone-adapted versions of the CRS-R and the Adverse Events Questionnaire. Neurophysiological and neuroimaging measures will complement clinical evaluations and provide data on brain activity. Resting-state high-density electroencephalography (EEG) will be acquired weekly during the whole inpatient phase. In addition, participants will be assessed before and after treatment with Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), EEG during auditory paradigms and 24-hours EEG recordings. To measure changes in circadian rhythm, body core temperature (Matsumoto et al., 2013) and body movements (Cruse et al., 2013) will be recorded with non-invasive portable devices throughout the whole duration of the inpatient phase (Figure 1). Statistical analyses will be performed blindly to detect changes in behavioral status, circadian rhythmicity, brain metabolism and functional connectivity both at the individual level (comparing before and after treatment) and at the group level (comparing the apomorphine and the placebo arms). Behavioral response will be determined by changes of diagnosis using the CRS-R, and further analyses will also look at changes between the non-responding and the responding patient subgroups. Age, gender, etiology, time since injury and diagnosis will also be included as regressors. Hypotheses: Based on the mesocircuit hypothesis, we postulate a modulation in the activity of the network’s anterior forebrain structures following administration of apomorphine (Figure 2), which will translate into the following changes: 1) A behavioral improvement such that the CRS-R diagnosis and total score will improve in responding patients, while NCS-R scores may also increase, reflecting a higher perception of pain; along with long-term functional recovery measured by sustained higher GOS-E and CRS-R scores at follow-up compared to the placebo group; 2) A relative recovery of sleep-wake cycles measured by a normalization of circadian rhythmicity as well as an increase in total body movements; 3) A metabolic improvement with significant increase of whole-brain glucose uptake, with highest increase of values found in the striatum, thalamus and frontoparietal cortical areas measured with PET; 4) A modulation of dynamic connectivity in response to apomorphine measured by resting-state fMRI analyses (seed-based and whole-brain connectivity measures) and changes of resting-state EEG connectivity metrics (notably increased mean alpha spectral connectivity, participation coefficient and delta modularity). Additionally, we can expect improvements after treatment in less specific measures of recovery such as sleep cycle architecture on 24-hours EEG hypnograms and the probability of consciousness given by a machine learning multivariate classifier derived from EEG recordings during auditory paradigms (Engemann et al., 2015). While improvements can be expected as well in the placebo arm due to spontaneous recovery and placebo effect, we hypothesize that responding patients in the apomorphine arm will exhibit significantly higher increases in these different markers of recovery. Discussion: New multimodal approaches using neurophysiology and neuroimaging allow a more accurate diagnosis of patients with disorders of consciousness but the current available treatments remain inefficient. This study aims to verify the efficacy of apomorphine for the recovery of consciousness in the first randomized placebo-controlled double-blind trial using multimodal measurement methods. The results will contribute to define the role of dopamine agonists in the treatment of this challenging population of patients and help identify the neural underpinnings underlying the modulation of consciousness networks by apomorphine. Notably, this trial is designed to bring objective neuroimaging and neurophysiological evidence to further assess the validity of the mesocircuit hypothesis and its modulation by pharmacological agents, which may open new therapeutic perspectives. [less ▲]

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See detailElderly and technologies: between myths and reality
Piccard, Sébastien ULiege; Pagacz, Pierre ULiege; Boulanger, Christelle et al

in European Geriatric Medicine (2018, October), 2018(9 (supp 1)),

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See detailThe use of PRISMA statement improves the reporting quality of meta-analyses published in the field of psychology
Leclercq, Victoria ULiege; Beaudart, Charlotte ULiege; Ajamieh, Sara ULiege et al

in Value in Health Regional Issues (2018, October), 21

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See detailAge-related changes in circadian sleep-wake regulation: Impact on cognitive performance and cerebral correlates
Schmidt, Christina ULiege; Reichert, Carolin; Deantoni, Michele ULiege et al

in Journal of Sleep Research. Supplement (2018, September 26)

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See detailTOWARDS AN ONTOLOGY FOR THE STRUCTURING OF REMOTE SENSING OPERATIONS SHARED BY DIFFERENT PROCESSING CHAINS
Nys, Gilles-Antoine ULiege; Kasprzyk, Jean-Paul ULiege; Hallot, Pierre ULiege et al

in International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2018, September 19), XLII(4), 483-490

This paper proposes an ontology to structure and describe processing chains in the remote sensing field. These chains are made up of elementary elements (operations) organized in collections. The ... [more ▼]

This paper proposes an ontology to structure and describe processing chains in the remote sensing field. These chains are made up of elementary elements (operations) organized in collections. The collection notion, including information about order and repeatability of the elements, is widely defined by using the relations between their constituting items and relations to the whole data store. Applications of the ontology are illustrated with web services provided by a platform for users and providers of processing chains. A graphical interface facilitates data integration in a RDF triple store. Thanks to the management of metadata (ISO19115-3), relevant information can be requested by intelligent search engines. Graph analysis, errors management and consistency rules are computed in order to gather coherent information from the different sources. Results of these analyses are then used by machine learning algorithms for new knowledge discovery. [less ▲]

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See detailInter- and intra-expert variability in sleep scoring: comparison between visual and automatic analysis
Muto, Vincenzo ULiege; Berthomier, Christian; Schmidt, Christina ULiege et al

in Journal of Sleep Research. Supplement (2018, September 11)

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See detailEvaluation of the Effect of Micro-Topography of a Potato Field on ERT to Assess Soil Moisture Patterns in Sandy Soil
Manhaeghe, Thibault ULiege; Wagner, Florian; Dumont, Gaël ULiege et al

in Earthdoc (2018, September 09)

Electrical resistivity tomography is a method that provides a spatial-temporal characterization of the subsurface. In this project, the method is used to monitor a potato field, characterized by a ... [more ▼]

Electrical resistivity tomography is a method that provides a spatial-temporal characterization of the subsurface. In this project, the method is used to monitor a potato field, characterized by a microtopography composed of furrows and ridges. Nevertheless, changes of this micro-topography due to erosion during the growing season could lead to artefacts in the inverted resistivity distribution. To quantify this effect, we first used a hydraulic model with non-uniform infiltration patterns and converted the obtained soil moistures in bulk resistivities. We then conducted a forward modelling with a decrease of the ridge height in the mesh. Afterwards, we used the initial microtopography of the start of the growing season in the inversion and compared the retrieved resistivity distributions to the ones of the hydraulic model. We also compared different array configurations to assess which array is most suitable to retrieve the expected infiltration pattern. Gradient and Wenner configuration were performing best with a coefficient determination coefficient close to 0.9 and a RMS close to 1. The change of ridge height highly impacted the coefficient of determination once the decrease is above 6 cm. Nevertheless, pattern between furrows and ridges can still be retrieved qualitatively up until a decrease of 10 cm. [less ▲]

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