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See detailFeasibility study of low-carbon ammonia and steel production in Europe
Hoxha, Jean-Luc ULiege; Caspar, Mathieu; Donceel, Alexis et al

in Eceee Industrial Summer Study Proceedings (in press)

As stipulated in the Paris Agreement, greenhouse gas emissions have to be reduced in order to maintain the global warming well below 2°C. Moreover, the European Union committed to become carbon neutral by ... [more ▼]

As stipulated in the Paris Agreement, greenhouse gas emissions have to be reduced in order to maintain the global warming well below 2°C. Moreover, the European Union committed to become carbon neutral by 2050. This will require shifting industrial production currently based on fossil energies towards the use of renewable energies. The present article considers two conceptual industrial processes that may operate in Europe with low carbon emissions through the use of green hydrogen. The studied processes are projections of the production of ammonia and steel in the 2030s. Hydrogen is assumed to be produced by water electrolysis with Proton Exchange Membrane electrolysers. The purpose of this paper being to evaluate the feasibility of such processes, it is assumed that the electricity required by the processes is entirely provided by renewable energies, in order to focus only on the challenges directly related to the ammonia and steelmaking plants. For the same reason, the prices are estimated in 2030 and not later, to avoid too uncertain costs assumptions, even if a complete supply by renewable energies may be unrealistic at that moment. Based on current industrial sectors of both ammonia and steel productions, a detailed modelling of the two decarbonised processes in Aspen Plus software is carried out and an economic analysis is also presented to prove the feasibility of these processes [less ▲]

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See detailRegards sur la néologie wallonne aujourd’hui. État des lieux et questionnements pour aujourd’hui et pour demain
Balthazard, Matthieu ULiege

in Langues et Linguistique (in press)

We first present the Belgian-Romance linguistic situation (1), and then propose an overview of the four centers in which neologisms appear in Wallonia. In the two first instances, which we call in vivo ... [more ▼]

We first present the Belgian-Romance linguistic situation (1), and then propose an overview of the four centers in which neologisms appear in Wallonia. In the two first instances, which we call in vivo, neologisms are created by Walloon speakers and message writers. In the two last ones, which we call in vitro, the words are elaborated by the "refondeurs" of Walloon or created during subsidized contests dedicated to neologisms. In this overview, we describe these instances externally (general presentation, organization, media...) and internally (principles of lexical creation at work, etc.) (2). Finally, we examine the links between neology, survival of dialects and standardization. In a context of disappearance of dialects and in a perspective of preservation of these, neology drives us to think about standardization and the ideological and practical questions underlying it (3). [less ▲]

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See detailI dipinti di Leonardo nella collezione reale francese nel XVII secolo
Fagnart, Laure ULiege

in Horti Hesperidum. Studi di storia del collezionismo e della storiografia artistica (in press)

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See detailLe “voile commun à tous meschans”. La justification de l’intolérance par la rhétorique du dévoilement dans la polémique catholique (France et Pays-Bas habsbourgeois, 1580–1594)
Goderniaux, Alexandre ULiege

in Loxias: Littératures Française et Comparées (in press)

This paper offers a comparative study of the polemical texts produced by the Catholic party in France and in the Southern Low Countries at the end of the 16th century. It focuses on the use of a specific ... [more ▼]

This paper offers a comparative study of the polemical texts produced by the Catholic party in France and in the Southern Low Countries at the end of the 16th century. It focuses on the use of a specific rhetoric strategy: the disclosure. In the case of France, this survey shows how this argument is linked to those of fear, war and truth within a deeply intolerant discourse which legitimizes a radical and intransigent hunt. Then, it studies how, on the contrary, the controversy produced in the Low Countries uses the rhetoric strategy of disclosure in a much more limited way, focused on the figure of a single enemy. [less ▲]

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See detailMulti-level governance and sanctuary cities: the case of Liege (Belgium) and undocumented migrants
Mescoli, Elsa ULiege

in Journal of Immigrant and Refugee Studies (in press)

Debates about migration issues are spread across various levels of contemporary Belgian society, where a process of policy restriction is in place, as well as federal discourse aimed at discouraging ... [more ▼]

Debates about migration issues are spread across various levels of contemporary Belgian society, where a process of policy restriction is in place, as well as federal discourse aimed at discouraging arrivals. This climate affects not only newcomers, but also those who have been residing in the country for years without managing to regularize their residence status. Within this global framework, local initiatives have developed to support migrants and their needs, as well as to propose broader political claims. In this article, I will discuss these issues by analyzing the case study of a group of undocumented migrants that occupied uninhabited buildings in Liège—with the help of a network of mobilized citizens and associations that are active in the territory— in order to launch a claims process for regularization. The local government of the city tolerates and supports the initiatives of the group to a certain extent, thus making Liège a “sanctuary city”, i.e. both a secure space for migrants and a setting for resistance. Such a socio-political space takes shape within a context of multi-level governance targeting migration issues (reception and integration), which is characterized by gaps in policy implementation and subsidiarity. Within this setting, undocumented migrants exert their agency and claim human and civil rights through a series of concrete mobilization actions. The aim of this article is to show how local action affects the process of migration governance in Belgium. [less ▲]

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See detailN, Fe single-doped and N-Fe co-doped TiO2 powders and films increasing photoactivity under visible light
Alié, Christelle ULiege; Caucheteux, Joachim; Douven, Sigrid et al

in Springer Series in Materials Science (in press)

This study aims to develop an eco-friendly and efficient photocatalytic coat-ing, active under a cost-effective visible LED system for the removal of or-ganic pollutants. An aqueous sol-gel process has ... [more ▼]

This study aims to develop an eco-friendly and efficient photocatalytic coat-ing, active under a cost-effective visible LED system for the removal of or-ganic pollutants. An aqueous sol-gel process has been used to produce N or Fe single-doped TiO2 photocatalysts as well as N-Fe co-doped TiO2 catalysts to extend its activity in the visible region. The physico-chemical properties of those catalysts were characterized by X-ray diffraction and diffuse reflec-tance spectroscopy and compared to commercial Evonik P25 TiO2. The use of dopants (N or Fe) extends the activity of TiO2 towards visible range. The photocatalytic activity of the undoped and doped catalysts has been studied by evaluating the degradation of the p-nitrophenol under visible light ( > 395 nm). Results show the increase of the p-nitrophenol degradation under visible light for all photocatalysts compared to undoped of commercial P25 TiO2, with the best results for the N-Fe co-doped TiO2 catalysts. Colloids prepared from these powders were spray-coated onto stainless steel sub-strates. After a large number of optimizations of the number of layers, of the roughness of the films, of the operating conditions of the spray-coating, a complete degradation of p-nitrophenol was obtained in 4 h at 18 °C with the TiO2-based coating doped with 43%mol of nitrogen and 0.25%mol of iron, and having an average thickness around 2 µm. [less ▲]

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See detailImpact de la Réalité Virtuelle sur le Niveau de Stress et le Sentiment de Compétence
Chaabane, Sourour ULiege; Etienne, Anne-Marie ULiege; Schyns, Michael ULiege et al

in Journal of Traumatic Stress (2021, July 02)

Virtual reality (VR) exposure is used in clinical psychology to treat anxiety disorders. It is also used to enhance resilience in soldiers by allowing them to confront virtual combat environments to help ... [more ▼]

Virtual reality (VR) exposure is used in clinical psychology to treat anxiety disorders. It is also used to enhance resilience in soldiers by allowing them to confront virtual combat environments to help fortify them against the negative consequences of trauma exposure. Most VR studies have focused on military and emergency medical staff; however, thus far, none have investigated VR in ambulance workers (AWs), who are confronted with traumatic situations daily. The current study aimed to assess the impact of a single VR exposure session on self-perceived competence and stress level in a sample of AWs. Participants (N = 40) were randomly assigned to either a VR immersion (i.e., experimental group, n = 20) or an audio immersion (i.e., control group, n = 20) of a shooting attack situation. We hypothesized that compared to controls, VR participants would report decreased anxiety, as measured using visual analog scales, as well as an increased sense of competence. The results showed a significant reduction in fear in both groups, d = 0.33, and an increased sense of competence in VR participants, d = 0.35. Although our hypotheses were only partially confirmed, the observed beneficial effects of VR and the audio immersion on stress levels in AWs suggest that VR exposure could be a useful way to increase resilience in AWs. [less ▲]

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See detailAn extension of CityJSON to support point clouds
Nys, Gilles-Antoine ULiege; Kharroubi, Abderrazzaq ULiege; Poux, Florent ULiege et al

in International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2021, June 30), XLII-B4-2021

The combination between dense point clouds and 3D vector objects permits new cartographic representation of urban information. This paper proposes an extension for the CityJSON encoding to support point ... [more ▼]

The combination between dense point clouds and 3D vector objects permits new cartographic representation of urban information. This paper proposes an extension for the CityJSON encoding to support point clouds. Following the 3.0 CityGML specifications, attributes and features are added to the core module of v1.0.1 CityJSON. Two solutions are proposed: inline complex geometries and external link to a remote file. The extended schema can be illustrated in four scenarios: detailed features visualization, fall-back solution in features reconstruction processes, simulating urban climate represented as vector fields, and true-to-life representation solution for complex elements such as solitary vegetation objects. It permits 3D city modelers to handle points clouds in a native way reducing files size and avoiding redundancy. All developments and documentation are available open-source. [less ▲]

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See detailTESSERAE3D: A benchmark for tesserae semantic segmentation in 3D point clouds
Kharroubi, Abderrazzaq ULiege; Van Wersch, Line ULiege; Billen, Roland ULiege et al

in ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2021, June 17), V-2-2021

3D point cloud of mosaic tesserae is used by heritage researchers, restorers, and archaeologists for digital investigations. Information extraction, pattern analysis, and semantic assignment are necessary ... [more ▼]

3D point cloud of mosaic tesserae is used by heritage researchers, restorers, and archaeologists for digital investigations. Information extraction, pattern analysis, and semantic assignment are necessary to complement geometric information. Automated processes that can speed up the task are highly sought after, especially new supervised approaches. However, the availability of labeled data necessary for training supervised learning models is a significant constraint. This paper introduces Tesserae3D, a 3D point cloud benchmark dataset for training and evaluating machine learning models, applied to mosaic tesserae segmentation. It is a publicly available, very high density and colored dataset, accompanied by a standard multi-class semantic segmentation baseline. It consists of about 502 million points and contains 11 semantic classes covering a wide range of tesserae types. We propose a semantic segmentation baseline building on radiometric and covariance features fed to ensemble learning methods. The results delineate an achievable 89% F1 score and are made available under https://github.com/akharroubi/Tesserae3D, providing a simple interface to improve the score based on feedback from the research community. [less ▲]

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See detailFeasibility study of an interferometric Small-Sat to study exoplanets
Dandumont, Colin ULiege; Defrere, Denis ULiege; Loicq, Jerôme ULiege

in Proceedings of SPIE: The International Society for Optical Engineering (2021, June 11), 11852

One of the main goals of exoplanet science is to characterize the atmosphere of rocky exoplanets in the habitable zone of nearby stars. A space-based nulling interferometry, observing in the mid-infrared ... [more ▼]

One of the main goals of exoplanet science is to characterize the atmosphere of rocky exoplanets in the habitable zone of nearby stars. A space-based nulling interferometry, observing in the mid-infrared (3-20 μm), is considered to be one of the most promising solutions to tackle this observing challenge. The LIFE project, a free-flying space-based mid-infrared nulling interferometer, would have this capability. However, several key technologies need to be demonstrated before launching such an ambitious mission. A small space-based mission can be considered as a useful prerequisite. In this paper, we consider three small satellite architectures, two CubeSats, and a PROBA-like satellite. Based on a Bracewell architecture and without free-flying, these monolithic satellites can demonstrate some key components like the null capability and its stability on real targets. The achromatic phase shifter needs also to be demonstrated in space. Based on the scientific capabilities and exoplanet detection yield of these architectures, optical constraints are derived (pointing stability, and optical path difference correction). Orbital simulations, exploring a range of classical orbits for such a satellite, are also discussed. [less ▲]

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See detailPacking dynamics of powders at high temperature
Neveu, Aurélien; Francqui, Filip; Lumay, Geoffroy ULiege

in EPJ Web of Conferences (2021, June 07), 249(12001),

In industrial powder processing, precise control of environmental temperature is difficult especially for large production facilities. A better knowledge of powder behavior modification due to temperature ... [more ▼]

In industrial powder processing, precise control of environmental temperature is difficult especially for large production facilities. A better knowledge of powder behavior modification due to temperature variation will help to improve product quality and consistency. From a fundamental point of view, the effect of temperature on powder flow and packing dynamics is still poorly understood. In particular, because temperature modifies the complex interplay between the different forces acting at the contact between the grains. The packing dynamics of a set of different powders (lactose, cacao and dried milk powder) has been investigated with a tapping experiment. After the filling procedure, the sample is heated and the evolution of the density is measured after each tap. We show that the packing dynamics is drastically influenced even for low temperature changes. Slight increase of temperature affects both the packing kinematics and the packing range characterised by the classical Hausner ratio analysis. Finally, the different physical mechanisms that could explain these modifications are discussed. The results of this preliminary study demonstrate the importance of temperature in powder behaviour and strongly motivate further investigations. [less ▲]

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See detailEffect of grain shape on the dynamics of granular materials in 2D rotating drum
Preud'Homme, Nicolas ULiege; Opsomer, Eric ULiege; Vandewalle, Nicolas ULiege et al

in EPJ Web of Conferences (2021, June 07), 249

We experimentally investigate the effect of the grain shape on the flow of granular material. The grain shape is modified to highlight the effect of grain circularity on granular flow in a 2D rotating ... [more ▼]

We experimentally investigate the effect of the grain shape on the flow of granular material. The grain shape is modified to highlight the effect of grain circularity on granular flow in a 2D rotating drum. Using a laser cutter, we create particles with decreasing circularity. We observe that the effect of grain shape depends on the rotation speed of the drum. For high rotation speed, granular flow is influenced by the packing’s dilatancy whereas, at low rotation speed, packing fraction seems to influence flowing dynamics. We link these two measurements to grain shape in order to explain its effect on granular flow. [less ▲]

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See detailAccompagner la mise en œuvre de l’approche par compétences dans les formations en santé : mise en perspective de plusieurs stratégies de changement
Quesnay, Paul ULiege; Poumay, Marianne ULiege

in Pédagogie Médicale (2021, May 27), 22(Suppl. 1), 15-16

Ces dernières années, les formations des professionnels de la santé ont fait l’objet de réformes visant à faire évoluer leurs curriculums vers une approche par compétences (APC). Or l’APC constitue un ... [more ▼]

Ces dernières années, les formations des professionnels de la santé ont fait l’objet de réformes visant à faire évoluer leurs curriculums vers une approche par compétences (APC). Or l’APC constitue un changement de paradigme pédagogique, avec une nouvelle conception de l’enseignement-apprentissage qui nécessite une révision de l’ingénierie pédagogique et des apprentissages spécifiques pour les coordinateurs et enseignants. La littérature fournit des guides, ainsi que des exemples de transformations curriculaires réussies dans le domaine de la santé mais pointe également un manque de documentation sur la manière dont les changements sont menés. A partir de deux stratégies de changement curriculaire proposées, trois thèmes ont guidé les échanges, à savoir : les points forts et limites de chaque stratégie, leur faisabilité de mise en œuvre, ainsi que les conditions par lesquelles elles peuvent être associées. [less ▲]

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See detailAccompagner la mise en œuvre de l’approche par compétences dans les formations en santé : perspectives d’une stratégie de changement pragmatique portée par un individu tercéisateur dans un institut de formation en ostéopathie
Quesnay, Paul ULiege; Poumay, Marianne ULiege; Gagnayre, Rémi

in Pédagogie Médicale (2021, May 26), 22(Suppl. 1), 152

Contexte : Ces dernières années, les formations des professionnels de la santé ont fait l’objet de réformes visant à faire évoluer leurs curriculums vers une approche par compétences (APC). Ces réformes ... [more ▼]

Contexte : Ces dernières années, les formations des professionnels de la santé ont fait l’objet de réformes visant à faire évoluer leurs curriculums vers une approche par compétences (APC). Ces réformes sont documentées dans leur mise en œuvre. Or l’APC nécessite une révision de l’ingénierie pédagogique et des apprentissages spécifiques pour les coordinateurs et enseignants. Se pose alors la question des stratégies mobilisées pour conduire le changement pédagogique, notamment au regard des ressources disponible au sein de l’institution. But : Analyser les effets d’une stratégie de changement initiée par un individu-tercéisateur pour la mise en œuvre de l’APC dans un institut de formation initiale en ostéopathie, à travers l’évolution des conceptions des coordinateurs. Méthodes : Cette étude qualitative s’inscrit dans une perspective socio-constructiviste, pragmatique et rejoint le cadre de l’éthique des curriculums en santé. Quatre coordinateurs pédagogiques ont participé à des productions pédagogiques et activités réflexives issues des recommandations sur l’APC : élaboration d’un référentiel, révision d’enseignements et d’outils évaluation. Des cartes conceptuelles individuelles ont été élaborées avec les coordinateurs pour suivre l’évolution de leurs conceptions avant et après les activités réflexives. Résultats : Les cartes conceptuelles attestent d’un apprentissage des coordinateurs vers l’APC montrant deux profils d’évolution des conceptions. Les mécanismes d’apprentissages relèvent d’une acculturation à partir d’objets-frontières (travaillés au cours des activités réflexives). Ces cartes conceptuelles, le caractère à la fois individuel et collectif des activités réflexives proposées ainsi que l’action de l’individu-tercéisateur ont permis de soutenir l’apprentissage et le changement. Conclusion : La stratégie étudiée montre à quelles conditions un individu formé à la posture de tercéisateur peut initier des changements pédagogiques en instaurant une dynamique-frontière entre des actions se situant à des niveaux individuels, collectifs et les nécessaires stratégies institutionnelles pour progresser vers l’APC. De même, individus-tercéisateurs, objets et dynamiques frontières constituent une perspective intéressante pour amorcer un changement curriculaire dans d’autres structures de formation qui ne rassembleraient pas toutes les conditions et ressources considérées comme porteuses dans la littérature, ou qui souhaiteraient faire de la formation pédagogique suivie par l’un de leurs enseignants une opportunité de changement. [less ▲]

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See detailIdentification and validation of an extended Stewart-Cazacu micromechanics damage model applied to Ti–6Al–4V specimens exhibiting positive stress triaxialities
Rojas-Ulloa, Carlos; Valenzuela, Marian; Tuninetti, Victor et al

in Proceedings of the Institution of Mechanical Engineers. Part L, Journal of Materials: Design and Applications (2021, May 06), 108(2),

In this research, the Stewart-Cazacu micromechanics coupled damage model is extended and validated adding nucleation and coalescence models as new damage mechanisms. The Ti–6Al–4V titanium alloy is chosen ... [more ▼]

In this research, the Stewart-Cazacu micromechanics coupled damage model is extended and validated adding nucleation and coalescence models as new damage mechanisms. The Ti–6Al–4V titanium alloy is chosen as a suitable hcp ductile material to be modeled using this extended damage law. The characterization of the damage evolution in this alloy is addressed throughout a quasi-static experimental campaign. Damage characterization relies on in-situ X-ray tomography data and Scanning Electron Microscopy (SEM) imaging technique. The validation procedure consists in the implementation into the finite element (FE) research software Lagamine of ULiège and in the comparison of numerical predictions and experimental results. Load-displacement curves and damage related state variables at fracture configuration from smooth and notched bar specimens submitted to tensile tests are analyzed. The nucleation and coalescence model extensions as well as an accurate elastoplastic and damage material parameter identification for Ti–6Al–4V samples are essential features to reach a validated model. The prediction capabilities exhibited for large strains are in good agreement with experimental results, while the near-fracture strains can still be improved. [less ▲]

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See detailConceptual Modeling Versus User Story Mapping: Which is the Best Approach to Agile Requirements Engineering?
Tsilionis, Konstantinos; Maene, Joris; Heng, Samedi ULiege et al

in Lecture Notes in Business Information Processing (2021, May)

User stories are primary requirements artifacts within agile methods. They are comprised of short sentences written in natural language expressing units of functionality for the to-be system. Despite ... [more ▼]

User stories are primary requirements artifacts within agile methods. They are comprised of short sentences written in natural language expressing units of functionality for the to-be system. Despite their simple format, when modelers are faced with a set of user stories they might be having difficulty in sorting them, evaluating their redundancy, and assessing their relevancy in the effort to prioritize them. The present paper tests the ability of modelers to understand the requirements problem through a visual representation (named the Rationale Tree) which is a conceptual model and is built out of a user stories' set. The paper is built upon and extends previous work relating to the feasibility of generating such a representation out of a user stories' set by comparing the performance of the Rationale Tree with the User Story Mapping approach. This is achieved by performing a two-group quantitative comparative study. The identified comparative variables for each method were understandability, recognition of missing requirements/epics/themes, and adaptability. The Rational Tree was not easy to understand and did not perform as anticipated in assisting with the recognition of missing requirements/epics/themes. However, its employment allowed modelers to offer qualitative representations of a specific software problem. Overall, the present experiment evaluates whether a conceptual model could be a consistent solution towards the holistic comprehension of a software development problem within an agile setting, compared to more `conventional' techniques used so far. [less ▲]

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See detailL’enseignement de la compétence relationnelle dans les instituts de formation initiales françaises : un manque de cohérence des curriculums
Quesnay, Paul ULiege; Poumay, Marianne ULiege; Gagnayre, Rémi

in Pédagogie Médicale (2021, May), 22(Suppl. 1), 24-25

Face à l’accroissement des maladies chroniques, un des enjeux est de développer des compétences d’éducation chez les soignants pour permettre de transférer des compétences au patient. En ostéopathie, les ... [more ▼]

Face à l’accroissement des maladies chroniques, un des enjeux est de développer des compétences d’éducation chez les soignants pour permettre de transférer des compétences au patient. En ostéopathie, les recommandations internationales témoignent de l’intérêt porté à ces enjeux à travers les activités de conseil de l’ostéopathe. Néanmoins, il est difficile de savoir en pratique comment se situe le conseil par rapport à l’information, à la communication ou à l’éducation, et des études précédentes pointent un besoin de mieux former les ostéopathes. En France, la dernière réforme (décrets) concernant la formation initiale a défini une compétence relationnelle qui inclut l'éducation du patient. Elle est peu documentée quant à son intégration dans les curriculums, et sur la formation des praticiens à l'éducation du patient. But : Déterminer comment les formations initiales en ostéopathie intègrent la compétence relationnelle, et questionner la place attribuée à l’éducation du patient. Méthode : Un questionnaire en ligne a été conçu suivant les 7 étapes recommandées par l’AMEE. Il a été administré à l’ensemble des instituts de formations initiale français (n=28). 8 instituts ont répondu à l’enquête. Résultats : La compétence relationnelle est apparue dans plusieurs enseignements, renforcée par l'apprentissage clinique à toutes les années de formations. Les enseignements n'étaient cependant pas spécifiques à cette compétence et leur volume d'heures était relativement faible. L'éducation des patients était considérée comme faisant partie de la compétence relationnelle et importante pour les répondants mais était peu mise en œuvre. Conclusions : Il semble y avoir un non-alignement entre les résultats de l'apprentissage, l'enseignement et l'évaluation. Les pratiques actuelles de formation ne sont pas suffisantes pour soutenir la compétence relationnelle, en particulier en ce qui concerne l'éducation des patients. Les résultats ont mis en évidence la nécessité de clarifier les décrets et d'améliorer la formation des formateurs. C'est à ces conditions que les écoles d'ostéopathie françaises pourront pleinement intégrer la compétence relationnelle. [less ▲]

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See detailSensitivity-enhanced localized surface plasmon resonance biosensing format dedicated for point-of-care testing tools
Hastanin, Juriy ULiege; Lenaerts, Cedric ULiege; Fleury-Frenette, Karl ULiege et al

in Proceedings of SPIE: The International Society for Optical Engineering (2021, April 16)

The main requirement for a point-of-care health monitoring tools is that it should involve relatively simple and inexpensive equipment ensuring acceptable accuracy of diseases early diagnostic. Quite ... [more ▼]

The main requirement for a point-of-care health monitoring tools is that it should involve relatively simple and inexpensive equipment ensuring acceptable accuracy of diseases early diagnostic. Quite commonly in practice, their main function is only to trigger an ‘alarm’ signal, when a specific biomarker of disease is detected in the sample. The affinity label-free biosensing involving surface plasmonic resonance (SPR) phenomena appears to be one of the most appropriate approaches for the above requirements. In our research, we focus on theoretical and experimental investigations of optional plasmonic-related biosensing formats easy to be integrated in lab-on-chip devices involving conventional planar SPR biosensing. One of such detection formats, mentioned in our earliest publications, involves localized surface plasmon resonance (LSPR) spectroscopy at the frustrated total internal reflection conditions (LSPR_TIR). In this paper, we report on the numerical and experimental study of LSPR_TIR spectroscopy of gold nanoparticles (NPs) structures with a relatively high density of NPs, manufactured using two different microfabrication methods: the conventional nano-sphere lithography, and the original one, involving the direct pulse laser writing. The last technology, developed by our research team, provides powerful and cost effective tools for flexible patterning of the disposable multichannel biochip with array of SPR and LSPR probes. The obtained results demonstrate a significant improvement in the LSPR wavelength sensitivity to sample refractive index. In addition, experimental investigations reveal a relatively efficient conversion of the incident light wave polarization that can be attributed to a relatively high efficiency of electromagnetic coupling between closely spaced NPs. [less ▲]

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See detailCompact laser altimeter dedicated to drone ballistic carriers
Hastanin, Juriy ULiege; Martin, Nicolas; Montfort, Francis ULiege et al

in Proceedings of SPIE: The International Society for Optical Engineering (2021, April 15)

Over the past few decades, the use of low cost Miniature Unmanned Aerial Vehicles (MUAV), as well as Micromechanical Flying Insects (MFI) in targets aerial surveillance and reconnaissance has experienced ... [more ▼]

Over the past few decades, the use of low cost Miniature Unmanned Aerial Vehicles (MUAV), as well as Micromechanical Flying Insects (MFI) in targets aerial surveillance and reconnaissance has experienced almost an exponentially growth not only in conventional military areas, but also in civil, industrial and aerospace applications. Despite obvious inherent advantages, such as a very attractive cost-efficiency ratio and a low risk to the drone operator safety, MUAV/MFI based technologies still present multiple challenges. The major drawback of conventional MUAV/MFI is that a relatively low on-board energy storage capacity and an inherent weakness of the MUAV/MFI propulsion drive systems. It results in a relatively low flight speed and an inability to fly in bad meteorological conditions, such as strong wind and could be critical for many applications, such as the forest fires or nuclear accident zones monitoring. In order to overcome these drawbacks, we propose to deliver MUAV/MFI to the designated target zone using ballistic carriers, such as mortar round or infantry man-portable unguided rocket. Accordingly, our research team intends to develop a prototype of MUAV/MFI ballistic carrier involving standard mortar rounds of 81 mm and 120 mm calibers. In this paper, we report the results of theoretical and experimental investigations on the MUAV/MFI ballistic carriers being developed by our research team and we address specifically the concept of compact laser altimeter dedicated to the ballistic carriers, as well as the first proof-of-concept experimental investigations, demonstrating its practical feasibility. One of the main challenges facing the implementation of the proposed concept of the mortar launched altimeter is to ensure its reliable operation after extremely high launch shock accelerations. This requirement determines the optical concept and materials selection and optimization, as well as the accuracy of alignment of the optical system. Recent mortar gun tests, performed in the frame of our experimental investigations, demonstrated that the key optical and electronic elements and sub-systems of the developed altimeter prototype can withstand launch accelerations of at least 5000g, as well as typical shock accelerations during parachute deployment phase. In additional, it should be noted that the fuze front surface area available for the placement of rangefinder optical lens assemblies is limited by military standards requirements, as well as by the air intake duct of the air drive turbine used as a power generator, that also poses some challenges for integrating the altimeter into mortar fuze head. The experimental investigations of the first altimeter prototype developed in compliance with these requirements, demonstrated the enabling range finding up to 1000 m, when operating at night time environments. [less ▲]

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See detailValidating a French-language version of Health Communication Assessment Tool: Content validity, test-retest reliability, interrater agreement, and implications for further development
Diep, Anh Nguyet ULiege; Servotte, Jean-Christophe; Dardenne, Nadia ULiege et al

in Advances in Simulation (2021, April 12), 6

Introduction The assessment of the communication skills of nurses in clinical settings bears both practical and educational significance. Despite the significance of communication skills to realize high ... [more ▼]

Introduction The assessment of the communication skills of nurses in clinical settings bears both practical and educational significance. Despite the significance of communication skills to realize high-quality patient-care, the development and validation of such an instrument applicable in different cultural contexts is still lacking and faces certain challenges. Additionally, the assessment of nurse-patient communication, which is dynamic and context-bounded, requires a fine-grained instrument, while not compromising the complexities of the skills under assessment. The aim of the present study was to test a French-language version of the Health Communication Assessment Tool (HCAT) (Campbell et al., 2013), on a French-speaking sample in Belgium against different measures of content relevance, validity, and reliability. Based on cognitive fluency perspective, we developed three simulated scenarios registering three levels of skill performance, including low, medium, and high demonstration. Thus, the psychometric properties of the HCAT instrument can be thoroughly examined. Methods Ten experts in communication and 52 nurse educators participated in the study. Firstly, the instrument was translated from English to French using back-translation technique. After semantic equivalence was agreed upon, the experts rated the relevance of the 22 items making up the HCAT, resulting in the removal of one culturally-irrelevant item. Subsequently, the experts and nurse educators rated the communication skills of the nurse in three scenarios. To ensure test-retest reliability, the nurse educators rated the scenarios twice within a four-week interval. The experts’ ratings were used as the gold standard when examining the reliability of the nurse educators’ ratings. Results & Discussion Exploratory and confirmatory factor analyses showed that the instrument could distinguish three aspects of communication skills, i.e. professional presentation, empathy, and trust building. Two-way random intraclass correlation coefficients (ICCs), ranging from 0.917 to 0.982, revealed that interrater agreement was excellent for consistency and absolute average-measures. However, at absolute single-measure, an ICC=0.425 suggested adequate interrater reliability for the medium-performed scenario, which decreased in low-performed (ICC=0.348) and high-performed (ICC=0.176) scenarios. Further, more than half of the items displayed poor test-retest reliability. [less ▲]

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See detailL'autodéfense intellectuelle, une pratique philosophique nécessaire aussi en démocratie
Herla, Anne ULiege; Jeanmart, Gaëlle ULiege; Compere, Aurore ULiege

in Diotime-l'Agora: Revue Internationale de Didactique de la Philosophie (2021, April), 88

Les ateliers d'autodéfense intellectuelle présentés dans cet article visent à s'attaquer à certaines expressions et pratiques langagières typiques de nos démocraties, qui finissent par les éroder. Ils ... [more ▼]

Les ateliers d'autodéfense intellectuelle présentés dans cet article visent à s'attaquer à certaines expressions et pratiques langagières typiques de nos démocraties, qui finissent par les éroder. Ils tendent à nous rendre collectivement attentif·ve·s aux idées et aux mots tellement ressassés qu'ils sont vidés de leur sens, aux subterfuges propres à noyer les poissons et à enfumer les esprits, aux discours qui prennent l'apparence de la raison sans en adopter la rigueur. Ces réflexes prophylactiques sont l'hygiène de base d'une démocratie saine, et ils s'appliquent autant aux discours qui nous entourent qu'à ceux que nous tenons sur nos propres activités, nouvelles pratiques philosophiques comprises. [less ▲]

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See detailOsteomodulin impacts positively the bone remodeling process in osteoarthritis
Zappia, Jérémie ULiege; Van der Cruyssen, Renee; Sanchez, Christelle ULiege et al

in Osteoarthritis and Cartilage (2021, April), 29(Suppl 1), 111

Osteomodulin (OMD) is a Small Leucine Rich Proteoglycan (SLRP) highly specific of the bone extracellular matrix. Its production and expression are impaired in subchondral bone sclerosis associated with ... [more ▼]

Osteomodulin (OMD) is a Small Leucine Rich Proteoglycan (SLRP) highly specific of the bone extracellular matrix. Its production and expression are impaired in subchondral bone sclerosis associated with osteoarthritis (OA). This study aimed to investigate the effects OMD on osteoblasts and osteoclasts in culture. [less ▲]

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See detailPotential Role of Epithelial Protein Disulphide Isomerases in Crohn’s Disease Fibrosis
Vieujean, Sophie ULiege; Hu, Shurong; Bequet, Emeline ULiege et al

in Acta Gastro-Enterologica Belgica (2021, March 03)

Background and aims: Intestinal fibrosis is a common complication of Crohn’s disease (CD) characterized by an accumulation of fibroblasts differentiating into activated myofibroblasts secreting excessive ... [more ▼]

Background and aims: Intestinal fibrosis is a common complication of Crohn’s disease (CD) characterized by an accumulation of fibroblasts differentiating into activated myofibroblasts secreting excessive extracellular matrix. In in-vitro experiments, this myofibroblastic differentiation is elicited by a whole series of factors among which transforming growth factor β1 (TGF-β1) seems to play a key role. The potential role of the intestinal epithelium in this fibrotic process remains poorly defined. Methods: We performed a pilot proteomic study comparing the proteome of surface epithelium isolated by laser-capture microdissection in normal and fibrotic zones of resected ileal CD strictures (13 zones collected in 5 patients). The pro-fibrotic role of selected epithelial proteins was investigated through in-vitro experiments using HT-29 epithelial cells and a CCD-18Co fibroblast to myofibroblast differentiation model. Results: Proteomic study revealed an endoplasmic reticulum (ER) stress proteins increase in the epithelium of CD ileal fibrotic strictures, including Anterior gradient protein 2 homolog (AGR2), Protein disulphide isomerase A6 (PDIA6) and Endoplasmic reticulum resident protein 44 (ERP44) which are 3 protein disulphide isomerases. In HT-29 cells, tunicamycin-induced ER stress triggered AGR2, PDIA6, ERP44 as well as TGF β1 intracellular expression and their secretion. Supernatant of these HT-29 cells, pre-conditioned by tunicamycin (Tm), led to a myofibroblastic differentiation when applied on CCD-18Co fibroblasts. The application of blocking agents for AGR2, PDIA6, ERP44 or TGF β1 in the supernatant of these Tm pre conditioned HT-29 cells, attenuated the myofibroblastic differentiation induced by this supernatant, suggesting a pro-fibrotic role of these secreted epithelial proteins. Conclusions: The development of CD fibrotic strictures may involve ER stress in epithelial cells, releasing a whole set of proteins into their environment, including AGR2, PDIA6, ERP44 as well as TGF-β1, which could exercise a pro-fibrotic role through a paracrine action. [less ▲]

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See detailThermodynamic optimality principles in Earth sciences
Schymanski, Stanislaus J.; Dewals, Benjamin ULiege; Dijkstra, Henk A. et al

in Geophysical Research Abstracts (2021)

Ecohydrological systems are a result of long-term co-evolution of soils, biota and atmospheric conditions, and often respond to perturbations in non-intuitive ways. Their short-term responses can be ... [more ▼]

Ecohydrological systems are a result of long-term co-evolution of soils, biota and atmospheric conditions, and often respond to perturbations in non-intuitive ways. Their short-term responses can be explained and sometimes predicted if we understand the underlying dynamic processes and if we can observe the initial state precisely enough. However, how do they co-evolve in the long-term after a change in the boundary conditions? In 1922, Alfred Lotka hypothesised that the natural selection governing the evolution of biota and composition of ecosystems may be obeying some thermodynamic principles related to maximising energy flow through these systems. Similar thoughts have been formulated for various components of the Earth system and individual processes, such as heat transport in the atmosphere and oceans, erosion and sediment transport in river systems and estuaries, the formation of vegetation patterns, and many others. Different thermodynamic optimality principles have been applied to predict or explain a given system property or behaviour, of which the maximum entropy production and the maximum power principles are most widespread. However, the different studies did not use a common systematic approach for the formulation of the relevant system boundaries, state variables and exchange fluxes, resulting in considerable ambiguity about the application of thermodynamic optimality principles in the scientific community. Such a systematic framework has been developed recently and can be tested online at: https://renkulab.io/projects/stanislaus.schymanski/thermodynamic_optimality_blueprint In the present study, we illustrate how such a common framework can be used to classify and compare different applications of thermodynamic optimality principles in the literature, and discuss the insights gained and key criteria for a more rigorous testing of such principles. [less ▲]

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See detailAssessment of lumped physically-based numerical models of dyke breaching
Schmitz, Vincent ULiege; Wylock, Grégoire; El Kadi Abderrezzak, Kamal et al

in Geophysical Research Abstracts (2021)

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See detailChallenging construction industry with C&DW: opportunities and limits
Courard, Luc ULiege; Zhao, Zengfeng ULiege; Hubert, Julien ULiege

in Revista Hormigon (2021), (H59), 33-45

Construction and Demolition Waste (C&DW) comprises the largest waste stream in the European Union (EU), with relatively stable amounts produced over time and high recovery rates: it is estimated at one ... [more ▼]

Construction and Demolition Waste (C&DW) comprises the largest waste stream in the European Union (EU), with relatively stable amounts produced over time and high recovery rates: it is estimated at one third of total wastes generated in the EU. Although this may suggest that the construction sector is highly circular, scrutiny of waste management practices reveals that C&DW recovery is largely based on backfilling operations and low-grade recovery, such as using recycled aggregates in road sub-bases. These wastes are usually recovered as secondary raw materials after a recycling process resulting in the production of recycled sands and aggregates. Researches have been performed to show how it is possible to encourage and support the use of these recycled materials: preparation process and selection are fundamental for increasing capability of recycling. Analysis of recycled bricks and tiles sands and fine particles has also been tested as substitution product in concrete design. A quantitative analysis is proposed for five North West European (NWE) countries: Belgium, France, Germany, Luxembourg and the Netherlands, where barriers are pointed out. The construction industry will be definitively affected by C&DW recycling for promoting circular economy in the coming years. [less ▲]

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See detailL'aventure cartésienne de la substance. « Ego autem substantia» dans l'ordre des raisons
Dubouclez, Olivier ULiege

in Revue Internationale de Philosophie (2021)

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See detailDevelopment of a space spectropolarimeter for full Stokes parameters retrieval.
Vasilescu, Bogdan ULiege; Nazé, Yaël ULiege; Loicq, Jerôme ULiege

in Proceedings of SPIE: The International Society for Optical Engineering (2020, December 13), 11451

This paper presents recent advancements in the study of a new concept of space spectropolarimeter. The instrument, based on a triple prismatic structure from a birefringent material, avoids the need of ... [more ▼]

This paper presents recent advancements in the study of a new concept of space spectropolarimeter. The instrument, based on a triple prismatic structure from a birefringent material, avoids the need of rotating components and may cover the entire Stokes vector for a very broad wavelength band. The analysis of the concept in noise-free conditions has proved its consistency. Further simulations for different geometries of the modulator are presented. The results allow identifying critical values for the main parameters. Moreover, the previous analysis of the instrument in noisy conditions is completed with the impact study of the spectral resolution, dimension of pixels and signal to noise ratio. [less ▲]

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See detailOptimizing Outcomes of Acute Leukemia After Transplants with Single Unrelated Cord Blood Units Selected According to Current International Recommendations for Cell Dose and HLA Match
Rafii, Hanadi; Kenzey, Chantal; Volt, Fernanda et al

in Bone Marrow Transplantation (2020, December 11), 55(4), 170-171

Selection of sCBU based on recommended cell dose and HLA criteria results in good engraftment and survival. When cell dose (TNC ≥ 2.5x107/kg) is respected, other factors such as HLA disparity have an ... [more ▼]

Selection of sCBU based on recommended cell dose and HLA criteria results in good engraftment and survival. When cell dose (TNC ≥ 2.5x107/kg) is respected, other factors such as HLA disparity have an impact on outcomes. [less ▲]

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See detailSeed shadows of northern pigtailed macaques within a degraded forest fragment, Thailand
Gazagne, Eva ULiege; Pitance, Jean-Luc ULiege; Savini, Tommaso ULiege et al

in Revue de Primatologie (2020, December 10), 11

Determining seed shadow (i.e. seed deposition pattern of a plant population) produced by frugivores is difficult to evaluate by direct observations, although of paramount importance to understand their ... [more ▼]

Determining seed shadow (i.e. seed deposition pattern of a plant population) produced by frugivores is difficult to evaluate by direct observations, although of paramount importance to understand their effectiveness as seed dispersal agents in degraded habitat. We developed a modeling approach of seed shadows incorporating field-collected data on a troop of 141 ± 10 individuals of northern pigtailed macaques (Macaca leonina) inhabiting a degraded forest fragment in Thailand, by implementing a mechanistic model of seed deposition with random components. We parameterized the model with macaque feeding behavior (i.e. consumed fruit species, seed treatments), gut and cheek pouch retention time, location of feeding sites and sleeping sites, monthly photoperiod, and movement patterns based on monthly native fruit availability using Hidden Markov models (HMM). We found that northern pigtailed macaques dispersed a majority of medium- to large-seeded species across large distances (mean > 500 m, maximum distance of 2300 m), promoting genetic mixing and colonization of plantation forests. Additionally, the macaques produced complementary seed shadows, with a sparse distribution of seeds spat out locally (mean > 50 m, maximum distance of 870 m) that probably ensures seedling recruitment of the immediate plant populations. Macaques’ large dispersal distance reliability is often underestimated and overlooked; however, their behavioral flexibility places them among the last remaining dispersers of large seeds in disturbed habitats. Our study shows that this taxon is likely to maintain significant seed dispersal services and promote forest regeneration in degraded forest fragments. [less ▲]

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See detailDevelopment of the SPECULOOS exoplanet search project
Sebastian, Daniel ULiege; Pedersen, P. P.; Murray, C. A. et al

in Proceedings of SPIE: The International Society for Optical Engineering (2020, December 01), 11445

SPECULOOS (Search for habitable Planets EClipsing ULtra-cOOl Stars) aims to perform a transit search on the nearest (< 40 pc) ultracool (< 3000K) dwarf stars. The project's main motivation is to discover ... [more ▼]

SPECULOOS (Search for habitable Planets EClipsing ULtra-cOOl Stars) aims to perform a transit search on the nearest (< 40 pc) ultracool (< 3000K) dwarf stars. The project's main motivation is to discover potentially habitable planets well-suited for detailed atmospheric characterisation with upcoming giant telescopes, like the James Webb Space Telescope (JWST) and European Large Telescope (ELT). The project is based on a network of 1m robotic telescopes, namely the four ones of the SPECULOOS-Southern Observatory (SSO) in Cerro Paranal, Chile, one telescope of the SPECULOOS-Northern Observatory (SNO) in Tenerife, and the SAINTEx telescope in San Pedro Martir, Mexico. The prototype survey of the SPECULOOS project on the 60 cm TRAPPIST telescope (Chile) discovered the TRAPPIST-1 system, composed of seven temperate Earth-sized planets orbiting a nearby (12 pc) Jupiter-sized star. In this paper, we review the current status of SPECULOOS, its first results, the plans for its development, and its connection to the Transiting Exoplanet Survey Satellite (TESS) and JWST. [less ▲]

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See detailReview and scientific prospects of high-contrast optical stellar interferometry
Defrere, Denis ULiege; Absil, Olivier ULiege; Berger, J.-P et al

in Proceedings of SPIE: The International Society for Optical Engineering (2020, December), 11446

High-contrast optical stellar interferometry generally refers to instruments able to detect circumstellar emission at least a few hundred times fainter than the host star at high-angular resolution ... [more ▼]

High-contrast optical stellar interferometry generally refers to instruments able to detect circumstellar emission at least a few hundred times fainter than the host star at high-angular resolution (typically within a few \lambda/D). While such contrast levels have been enabled by classical modal-filltered interferometric instruments such asVLTI/PIONIER, CHARA/FLUOR, and CHARA/MIRC the development of instruments able to fi lter out the stellar light has signi cantly pushed this limit, either by nulling interferometry for on-axis observations (e.g., PFN, LBTI, GLINT) or by o -axis classical interferometry with VLTI/GRAVITY. Achieving such high contrast levels at small angular separation was made possible thanks to signi cant developments in technology (e.g., adaptive optics, integrated optics), data acquisition (e.g., fringe tracking, phase chopping), and data reduction techniques (e.g., nulling self-calibration). In this paper, we review the current status of high-contrast optical stellar interferometry and present its key scienti c results. We then present ongoing activities to improve current ground-based interferometric facilities for high-contrast imaging (e.g., Hi-5/VIKING/BIFROST of the ASGARD instrument suite, GRAVITY+) and the scienti c milestones that they would be able to achieve. Finally, we discuss the long-term future of high-contrast stellar interferometry and, in particular, ambitious science cases that would be enabled by space interferometry (e.g., LIFE, space-PFI) and large-scale ground-based projects (PFI). [less ▲]

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See detailPerformance study of interferometric small-sats to detect exoplanets:Updated exoplanet yield and application to nearby exoplanets
Dandumont, Colin ULiege; Kammerer, Jens; Defrere, Denis ULiege et al

in Proceedings of SPIE: The International Society for Optical Engineering (2020, December), 11446

Nulling interferometry is considered as one of the most promising solutions to spectrally characterize rocky exoplanets in the habitable zone of nearby stars. It provides both high angular resolution and ... [more ▼]

Nulling interferometry is considered as one of the most promising solutions to spectrally characterize rocky exoplanets in the habitable zone of nearby stars. It provides both high angular resolution and starlight mitigation. It requires however several technologies that need to be demonstrated before a large interferometry space-based mission flies. A small-sat mission is a good technological precursor. Based on a Bracewell architecture, this unique satellite can demonstrate some key components (null capability, fiber injection, achromatic phase shifter). Scientific capabilities of such a mission are presented. An exoplanet detection yield is derived, and we show that the detection of exoplanets around nearby stars is feasible. [less ▲]

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See detailMise au point d’un modèle de culture original de cellules musculaires squelettiques à partir de biopsies musculaires humaines
Florin, Antoine ULiege; Lambert, Cécile ULiege; Sanchez, Christelle ULiege et al

in Revue du Rhumatisme (2020, December), Volume 87(Supplément 1),

The objective of this work was to develop a culture model of primary skeletal muscle cells obtained from human muscle biopsies.

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See detailLes forces dans l’image et les gestualités émotionnelles
Dondero, Maria Giulia ULiege

in SHS Web of Conferences (2020, November 12), 81

This article focuses on the relationship between visual language and emotions. The paper consists of two parts: the first is devoted to the forces inside the image, the second to emotional gestures, that ... [more ▼]

This article focuses on the relationship between visual language and emotions. The paper consists of two parts: the first is devoted to the forces inside the image, the second to emotional gestures, that is to say, to the enunciative practices of the body that accompany the interpretation and appreciation of images. The first part discusses René Thom’s contribution to the reflections on the emotions of aesthetic contemplation in light of the deployment of forces in the paintings; while the second part contrasts manual and computational analysis with regard to the gestures of the analyst and the observer. Manual analysis is illustrated through the teaching practice of Roland Barthes at the Collège de France, while computational analysis is explored through the experiments of Lev Manovich and Cultural Analytics. [less ▲]

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See detailEvaluating the Software Problem Representation on the Basis of Rationale Trees and User Story Maps: Premises of an Experiment
Tsilionis, Konstantinos; Maene, Joris; Heng, Samedi ULiege et al

in Lecture Notes in Business Information Processing (2020, November), 407

User stories describe system requirements from the users' point of view using structured natural language. These artifacts mostly assist the development team in agile projects where sets of them express ... [more ▼]

User stories describe system requirements from the users' point of view using structured natural language. These artifacts mostly assist the development team in agile projects where sets of them express the expected features of the to-be software. Nevertheless, when faced with large user stories’ sets, further structuring needs to be introduced to make the software problem more understandable/clear. Indeed, the latter can hardly be understood on the basis of huge flat lists of sentences. The present paper describes the premises of an experiment destined to evaluate whether novice modelers can understand the requirements problem better through a visual representation (called Rationale Tree) built out of a user stories’ set. It does so by comparing, on the same objective, the Rationale Tree method to the industry-adopted User Story Mapping technique with a modeling exercise. This was performed with the participation of two student groups where one used the former technique while the other one employed the latter. The ultimate goal of this exercise is to identify the actual performance of the Rational Tree in delivering understandability to the requirements problem (when input is provided in the form of a complex user stories’ set) in order to identify possible bottlenecks and improvement opportunities within the method itself. [less ▲]

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See detailIntegrating Risk Representation at Strategic Level for IT Service Governance: A Comprehensive Framework
Aghakhani, Ghazaleh; Wautelet, Yves; Kolp, Manuel et al

in Lecture Notes in Business Information Processing (2020, November), 400

Organizations tend to set and pursuit objectives against an environment which faces levels of uncertainty. The effect of these uncertainties on objectives can be positive (opportunity risk) or/and ... [more ▼]

Organizations tend to set and pursuit objectives against an environment which faces levels of uncertainty. The effect of these uncertainties on objectives can be positive (opportunity risk) or/and negative (hazard risk). With every decision made by people within a company, risks are created, modified, updated or deleted. Therefore, the way these decisions are made in terms of change management strategy as well as the information they are based on, influence how objectives are achieved and requirements fulfilled. Despite the importance of risk definition and risk taking at all organizational levels, organizations mostly consider risk at the management and operational levels. Risks nevertheless also need to be considered at the strategic (governance) level because they constitute what hampers an organization to achieve its strategy. This paper focuses on risk at the strategic level and for this purpose it enriches the Model Driven IT Governance (MoDrIGo) framework; the enriched framework allows to evaluate the alignment of business IT services with strategic objectives while balancing this alignment/support with the potential risk at governance level. All in all, the framework is applicable in broader governance scenarios. The relevance of MoDrIGo as starting point to build a risk-aware governance framework (compared to other similar methods) is mainly because of its service-orientation and its focus on software development issues. The enhanced framework thus provides a high-level risk overview that helps organizations to successfully perceive, detect and treat risks when pursuing their objectives. [less ▲]

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See detailالمرأة العلويّة بين مطرقة الحرب و سندان الميديا
Kassab, Madeleine ULiege

in Al Kitab Journal for Human Sciences (2020, November), Special Issu

Since the protesting movements in several Arab countries erupted, the internet, especially the social media, has turned into a real war arena. A “Facebook revolution” or a “Twitter revolution” are terms ... [more ▼]

Since the protesting movements in several Arab countries erupted, the internet, especially the social media, has turned into a real war arena. A “Facebook revolution” or a “Twitter revolution” are terms that have been used to signify the role of this media in planning, organizing and reporting the peaceful protests and the armed conflicts live and instantaneously. The media blackout and the tight censorship on journalists are considered an important reason why the social media sites have become the first news source for many traditional media. The division of the Syrian society into supporters and opponents of the government and the president Bashar Al-Assad was clearly reflected in the interactive media which turned into platforms of swearing, threats and proudly displaying the images of the murdered people and hostages. The recipients of traditional media have become senders and receivers at the same time because of the social media. This has made them contribute to the process of spreading the propaganda of the camp to which they belong. They have rather become an essential contributor to the psychological war. The Syrian opposition attempted to confront the government and the president Al-Assad through media in different ways the most important of which is YouTube. The purpose of this qualitative-semiotic study is analyzing the image of the Alawite woman that is presented by some of Al-Assad opponents on YouTube in order to know how this woman is being used as a weapon in the psychological war. The importance of the research lies in uncovering the mental images which the opposition attempts to depict or reinforce about the Alawite woman in the context of a conflict in which sectarianism is considered one of its most prominent pillars; it is so at least for some of the fighting parties, and in a context where the peoples harvest the disasters which result from politicizing religion and religionizing politics. According to the results of the study, the Alawite woman has been considered a traitor of the Syrian people, murderer, kidnapper and sexual tool in the hand of the regime. The opponents have often linked the Alawite identity to the moral descent especially on the sexual level. [less ▲]

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See detailHigh plasmatic levels of IL-4 and IL- 13 are associated with recurrence and worse survival in breast cancer
Onesti, Concetta Elisa ULiege; JOSSE, Claire ULiege; Boulet, Delphine ULiege et al

in Tumori Journal (2020, October 31)

Background: The immune system has a role in breast tumor, in particular in triple negative (TNBC) and in hormone receptor-negative/HER2-positive breast cancers. The aim of this study is to analyze the ... [more ▼]

Background: The immune system has a role in breast tumor, in particular in triple negative (TNBC) and in hormone receptor-negative/HER2-positive breast cancers. The aim of this study is to analyze the association between baseline cytokines expression with cancer relapse and outcome. Material and methods: Baseline plasmatic samples of 66 stage I-III breast cancers treated with surgery with or without radiotherapy and systemic treatment between 2011 and 2017 were collected. A panel of 24 cytokines were analyzed by Luminex MAGPIX technology, using multiplex Luminex Magnetic Assay kits (®R&D System). Results: Sixty-six breast cancer patients were included in the study. The median follow-up was of 78 months (range 18-99). The median age at diagnosis was of 58.5 years (range 32-86). The stage at diagnosis was I in 29 (43.9%) patients, II in 26 (39.4%) and III in 11 (16.7%). The histological type was ductal in 47 cases (71.2%), lobular in 13 (19.7%) and mixed in 6 (9.1%). Fifty-three (80.3%) patients were estrogen-receptor-positive, 11 (16.7%) HER2-positive and 12 (18.2%) TNBC. All the patients received surgery, combined with neo/adjuvant chemotherapy in 35 (53%) cases, anti-HER2 in 9 (13.6%), hormonotherapy in 53 (80.3%) and radiotherapy in 52 (78.8%). During the follow-up we observed 11 relapses and 4 deaths. IL-4 was associated with relapse, that occurs in 30.7% of the cases in the group with IL-4 > 0.07 (IL4-H) mean fluorescence intensity (MFI) vs in 7.5% in the group with IL-4 ⩽ 0.07 MFI (IL4-L) (p 0.013), with a ROC curve AUC of 0.745. In multivariate analysis relapse was associated with IL-13 (p 0.048) and T stage (p 0.049). Survival analysis showed a better time to treatment failure (TTF) for the group IL4-L (5y-TTF 87% vs 63% for IL4-L and IL4-H, p 0.022) and for the group with IL-13 ⩽ 0.1 MFI (IL13-L) compared IL-13 > 0.1 MFI (IL13-H) (5y-TTF 90% vs 45%, p 0.017). A separation of the curves was also observed for breast cancer specific survival (5y-BCSS: 95% vs 84% for IL4-L vs IL4-H, p 0.118; 91% vs 75% for IL13-L vs IL13-H, p 0.029). Conclusions: Higher baseline plasmatic level of IL-4 and IL-13 are associated with a worse prognosis in early stage breast cancer. These are two structurally and functionally related cytokines known for regulating the immune system activity, leading to a T helper-2 response and to a macrophage M2 polarization. Data should be confirmed in a larger cohort and a mechanistic study is advisable. [less ▲]

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See detailAnisotropic conductive film & flip-chip bonding for low-cost sensor prototyping on rigid & flex PCB
Stoukatch, Serguei ULiege; André, Nicolas; Delhaye, Thibault et al

in IEEE Sensors (2020, October 25)

We developed a low-cost process for assembling versatile sensors without expensive, thick metal finish on rigid and flexible PCB using anisotropic conductive films (ACF) flip-chip (FC) process. This ... [more ▼]

We developed a low-cost process for assembling versatile sensors without expensive, thick metal finish on rigid and flexible PCB using anisotropic conductive films (ACF) flip-chip (FC) process. This allows a lower temperature budget than conventional FC assembly. The ACF FC process requires no expensive set up, is quick to implement and suits perfectly for sensor prototyping and low-scale manufacturing. The process was directly applied to assemble the bare die of a CMOS strain gauge sensor on flexible PCB without compromising its integrity. [less ▲]

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See detailAspergillus qPCR testing on nasal swab: A useful tool for diagnosis and follow‐up of sinonasal aspergillosis in dogs?
Biénès, Tom ULiege; Fastrès, Aline ULiege; Vangrinsven, Emilie ULiege et al

in Journal of Veterinary Internal Medicine (2020, October 17)

Polymerase chain reaction (PCR) testing either for Aspergillus.spp or for Aspergillus fumigatus is now available; however, the interest of such tests in the diagnosis of canine sinonasal aspergillosis ... [more ▼]

Polymerase chain reaction (PCR) testing either for Aspergillus.spp or for Aspergillus fumigatus is now available; however, the interest of such tests in the diagnosis of canine sinonasal aspergillosis (SNA) has not yet been assessed. The aim of this study was to evaluate the presence of fungal material using qPCR targeting Aspergillus.spp (PanAsp) and A. fumigatus (Aspfum) in samples obtained from nasal cavities of dogs with various nasal diseases and healthy dogs. In SNA dogs, Aspfum and PanAsp were positive in 13/20 and 14/20 dogs with a mean cycle threshold (Ct) of 30.6 [range 23,2 ‐ 33,3] and 28.3 [24,3 ‐ 34,5], respectively. The PanAsp was also positive in 3 non‐SNA dogs: one with cured SNA, one with LPR and one with nasal tumor, but at very low load (Ct>33). Results between both qPCR were highly correlated (r = 0.8, P < 0.01). For Aspfum and PanAsp, the sensitivity was 65% and 70% and the specificity was 100% and 94%, respectively. Aspfum qPCR test on deep blinded nasal swabs appears highly specific but only moderately sensitive to diagnose canine SNA. In some dogs fungal plaques are exclusively found in the frontal sinus and are probably not reached by blinded sampling. Since A. fumigatus is the most common etiological agent of canine SNA (96.7% of isolates), Aspfum testing appears appropriate; however, PanAsp testing is a non‐negligible tool to detect the small percentage of SNA cases related to other Aspergillus species. Results also show that healthy predisposed dogs do not seem to be carriers and confirm that A. fumigatus does not appear to have a major role in LPR. The negative results found in cured SNA dogs show a good correlation with clinical and rhinoscopic findings. In conclusion, Aspfum and/or PanAsp (qPCR testing) on deep nasal blinded swabs can be useful for the detection of SNA at diagnosis and after cure. [less ▲]

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See detailThe relative eosinophil count in breast cancer as an emerging prognostic biomarker
ONESTI, Concetta Elisa ULiege; JOSSE, Claire ULiege; Beaumecker, Barbara ULiege et al

in European Journal of Cancer (2020, October 02)

Background: Cancer outcome appears to be affected by circulating immune cells in several tumor types. The role of peripheral eosinophils was widely studied in melanoma, while less data are available for ... [more ▼]

Background: Cancer outcome appears to be affected by circulating immune cells in several tumor types. The role of peripheral eosinophils was widely studied in melanoma, while less data are available for breast cancer (BC) so far. In a previous study, we showed an association between baseline relative eosinophil count (REC), pathological complete response and survival rate in triple negative and hormone receptor negative/HER2 positive breast cancer. In this retrospective study we analyzed the role of REC in all breast cancer subtypes at time of diagnosis and during follow-up. Material and Methods: Stage I-III BC patients (pts) treated between 1999 and 2018 were included in the study. REC and relative lymphocyte count (RLC) at seven different timepoints were collected. The pts were divided into two groups according to REC, using 1.5% as threshold, and according to RLC, using 17.5% as threshold. The co-primary endpoints were the BC specific survival (BCSS) and the time to treatment failure (TTF) according to REC. The secondary endpoints were: BCSS and TTF according to RLC, the association between REC and RLC with relapse; the variation of REC during follow-up and at relapse. Statistical analysis was done with SPSS v25 software. Results: Overall 930 early BC pts were included in the study. The median age of the whole cohort was 61 years (25–97). The pts were well balanced according to the TNM stage in the group REC-low (393 pts) and in the group REC-high (597 pts): 30.5% and 32.9% stage I; 45.3% and 45.1% stage II; 22.6% and 21.4% stage III respectively; 1.4% unknown. After a median follow-up of 91 months (range 1–245) we observed a benefit in TTF (HR 0.610–95% CI 0.458–0.812, p 0.001) and BCSS (HR 0.632–95%CI 0.433– 0.923, p 0.018) in REC-high vs REC-low group. A survival benefit was observed also in the RLC-high vs RLC-low group (TTF: HR 0.421–95% CI 0.262–0.677, p 0.001; BCSS: HR 0.350–95% CI 0.2–0.614, p 0.001). A lower rate of relapse was observed in the REC-high vs REC-low group (17.1% vs 24.7%, p 0.005) and in the RLC-high vs RLC-low group (19.4% vs 35.8%, p 0.004). We observed a lower median REC at baseline before surgery (1.8% and 1.4% in pts without and with relapse respectively), compared to the median value after surgery (2.7% and 2.5% respectively), that remain stable until 10 years of postsurgical follow up in cancer free pts. A decrease in median REC was detected at time of relapse (1.5%). All the differences observed in the groups of pts with and without tumor recurrence were statistically significant (p < 0.0001), suggesting a role of the presence of cancer in the modulation of eosinophil count. Conclusions: REC could be a new promising, affordable and accessible predictive and prognostic biomarker in all BC subtypes. Mechanistic studies, ongoing in our laboratory, are needed to understand eosinophils’ physiopathological role. [less ▲]

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See detailOn Water Ice in Cometary Outbursts
Kelley, M.; Protopapa, S.; Moulane, Youssef ULiege et al

in Bulletin of the American Astronomical Society (2020, October 01), 52

Cometary outbursts are brief, but potentially strong, mass-loss events, likely caused by a wide range of phenomena [1]. Using near-infrared (near-IR) spectroscopy, water ice grains have been observed in ... [more ▼]

Cometary outbursts are brief, but potentially strong, mass-loss events, likely caused by a wide range of phenomena [1]. Using near-infrared (near-IR) spectroscopy, water ice grains have been observed in the ejecta of some cometary outbursts. These detections present us with opportunities to study the properties of a cometary ice, and potentially infer the properties of the nucleus at the site of the event. <P />We present a detailed analysis of a large outburst (∆m~3 mag) of comet 243P/NEAT that occurred in December 2018, at 2.55 au from the Sun. Our study combines photometry, imaging, and spectroscopy with dynamical and thermophysical models of dust and ice grains. Overall, the outburst ejected ~10[SUP]8[/SUP] kg of dust. We find no photometric or spectroscopic evidence for water ice in our data, which includes near-IR spectroscopy (1─2.5 μm) taken 4 days after the outburst. Nevertheless, this does not necessarily imply that water ice was not ejected by the outburst. Specifically, we consider the possibility that the ejecta from 243P had ice with the same properties as comet C/2013 US[SUB]10[/SUB] (Catalina): micrometer-sized grains mixed with a small fraction of low-albedo dust, ~0.5% by volume [2]. These physical properties can account for our 243P/NEAT observations on thermophysical and dynamical grounds, i.e., the icy grains are depleted in our spectroscopic slit due to ice sublimation and their expansion speed. <P />The lack of water ice absorption features in our near-IR spectrum is in stark contrast to the outbursts of comets 17P/Holmes and P/2010 H2 (Vales), which had the signatures of water ice 7 and 6 days post-outburst, respectively [3,4], despite occurring at similar heliocentric distances and spanning a wide range of ejected masses (10[SUP]8[/SUP] kg for Vales, 10[SUP]11[/SUP] kg for Holmes) [5]. We consider the dynamical and thermophysical properties of water ice grains in each event, and discuss three possibilities for the differences: (1) that the site of the 243P outburst has a low abundance of water ice caused by surface processing or natal heritage; (2) that ice observed at Holmes and/or Vales was not from the original outburst, but instead produced after the event; and/or, (3) that a diversity of water ice properties exists in the comet population. We conclude that further studies of cometary outbursts that combine dynamical, spectroscopic, and thermophysical considerations will help advance our general understanding of water ice in comets. <P />1: Hughes 1990, QJRAS, 31, 69 ; 2: Protopapa et al. 2018, ApJL, 862, 16 ; 3: Yang et al. 2009, AJ 137, 4538 ; 4: Yang and Sarid 2010, DPS 42, 5.09 ; 5: Ishiguro et al. 2016, AJ 152, 168 [less ▲]

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See detailProbing the chemical composition of interstellar comet 2I/Borisov using ALMA
Cordiner, M.; Milam, S.; Biver, N. et al

in Bulletin of the American Astronomical Society (2020, October 01), 52

Interstellar comet 2I/Borisov originated from the direction of Cassiopeia, and passed through the inner Solar System, reaching perihelion on 2019-12-08, giving us an unprecedented opportunity to study an ... [more ▼]

Interstellar comet 2I/Borisov originated from the direction of Cassiopeia, and passed through the inner Solar System, reaching perihelion on 2019-12-08, giving us an unprecedented opportunity to study an object from another planetary system in close-up. We used the Atacama Large Millimeter/submillimeter Array (ALMA) to observe coma gases from 2I/Borisov on 15th-16th December 2019, at high spectral and spatial resolution. Emission from HCN (J=4-3) and CO (J=3-2) was detected, peaking at the expected position (and velocity) of 2I/Borisov's nucleus. Molecular production rates were derived using a 3D non-LTE radiative transfer code, including excitation due to gas collisions and radiative pumping. The HCN abundance relative to water (~0.12%) was found to be similar to typical Solar System comets, but the CO abundance (~68%) was among the highest observed in any comet within 2 au of the Sun. The observed CO/HCN ratio is an order of magnitude larger than the average ratio in Solar System comets, which shows that 2I/Borisov must have formed in a relatively CO-rich environment. Either 2I/Borisov is intrinsically enriched in CO, or the outgassing of the less-volatile species (H2O and HCN) was more strongly inhibited than usual, relative to the more-volatile CO. Various explanations for the CO-richness of 2I/Borisov's coma will be examined, and the importance of interstellar objects for our understanding of protoplanetary disk midplane chemistry will be discussed. See Cordiner et al. (2020, Nature Astronomy, doi:10.1038/s41550-020-1087-2) for further details. <P />This research was supported by the National Science Foundation (under Grant No. AST-1614471), and by the NASA Planetary Science Division Internal Scientist Funding Program through the Fundamental Laboratory Research (FLaRe) work package. Part of this research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. [less ▲]

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See detailHeterogeneous surface of 1998 OR2
Devogèle, M.; Virkki, A.; Marshall, S. E. et al

in Bulletin of the American Astronomical Society (2020, October 01), 52

We report observations of the H=15.8 mag potentially hazardous asteroid 52768 (1998 OR2) obtained during its 2020 apparition. On April 29th 2020, OR2 experienced its closest approach to Earth (16.4 Lunar ... [more ▼]

We report observations of the H=15.8 mag potentially hazardous asteroid 52768 (1998 OR2) obtained during its 2020 apparition. On April 29th 2020, OR2 experienced its closest approach to Earth (16.4 Lunar distance) until 2079. Observations were obtained in polarimetry with the Torino Polarimeter at the Calern observatory (France; MPC 010) in February and April 2020, in radar with the Arecibo Radio telescope (Puerto Rico; MPC 251) Planetary Radar system from April 13th to 23rd 2020, and in photometry with the TRAPPIST-North and the Las Cumbres observatory (LCOGT) network of telescopes. One epoch was obtained by the NEOWISE mission. <P />Using the polarimetric albedo-polarization relation [1] we derived a visual albedo p[SUB]V[/SUB] = 0.16 ± 0.02 corresponding to an equivalent diameter of D=2.3 km based on its measured H=15.8 absolute magnitude. The NEOWISE observation provides other determinations of D=2.5 ± 0.5 km and p[SUB]V[/SUB] = 0.13 ± 0.04 consistent with the polarimetric data. Radar delay-Doppler images, with a resolution of 7.5 m per pixel in delay and 0.037 Hz in frequency, provide another independent size measurement and display a maximum extent of 2.16 km ± 0.05 km. Both radar and optical lightcurve observations confirm the rotation period of p=4.112 h [2], with a low amplitude lightcurve varying from single to double peaked, based on the phase angle and aspect angle variation throughout the apparition. <P />The polarimetric observations were conducted over more than one rotation period during each night and we observe a consistent phase-locked variation of the polarization. Asteroid polarization is independent of shape and is at first order dependent on the surface albedo. The observed variation of the polarization thus suggests that the surface of OR2 is heterogeneous. Such variation has only previously been observed for 4 Vesta [3], 1943 Anteros [4], and 3200 Phaethon [5,6]. <P />The radar images of OR2 suggest the presence of a large concavity or crater near the radar sub-latitude (closest point of the object to the observer). Phasing the radar and polarimetric observations, we find that the maximum of polarization occurs when the radar concavity is directly facing the observer. Such correlation suggests that the polarimetric variations could be related to the presence of the concavity and that it possesses lower albedo or different scattering properties than the rest of the surface. <P />1: Cellino et al., 2015 MNRAS, 451, 3473 ; 2: Skiff et al, 2019, MPB, 46 ; 3: Cellino et al., 2016, MNRAS, 456, 248 ; 4: Masiero et al., 2010, Icarus, 207, 795 ; 5: Devogèle et al., 2018 MNRAS, 465, 4335 ; 6: Borisov et al., 2018 MNRAS, 480, L131 [less ▲]

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See detailShape Model, Pole Solution Implications, and Refined Rotational Period of (155140) 2005 UD
Kueny, J. K.; Chandler, C. O.; Devogèle, M. et al

in Bulletin of the American Astronomical Society (2020, October 01), 52

(155140) 2005 UD is a Near-Earth Asteroid in a companion orbit with (3200) Phaethon, an active asteroid in a highly-elliptical orbit thought to be responsible for the Geminid meteor shower. Evidence ... [more ▼]

(155140) 2005 UD is a Near-Earth Asteroid in a companion orbit with (3200) Phaethon, an active asteroid in a highly-elliptical orbit thought to be responsible for the Geminid meteor shower. Evidence points to a genetic relationship between these two objects (Devogèle et al. 2020), but we have yet to fully understand how 2005 UD and Phaethon could have separated into this associated pair. Notably, 2005 UD is the extended mission target for the Japanese Aerospace Exploration Agency DESTINY+ mission scheduled to launch in 2024. Presented herein are new observations of 2005 UD using the Lowell Discovery Telescope, Nordic Optical Telescope, and TRAPPIST-North motivated by access to a previously unseen viewing geometry in October-November 2019. Lightcurve inversion using our new data, archival lightcurve data from an advantageous apparition in late 2018, and data from an epoch in late 2005 were used to derive a shape model of 2005 UD. Results pertaining to 2005 UD's mass loss from additional analyses involving these new data will also be discussed. We also determined a retrograde spin state, largely consistent with a previous thermophysical analysis, and a refined sidereal rotational period of P[SUB]sid[/SUB] = 5.2338 ± 0.0040 hours. Although a precise shape model is at present infeasible due to remaining gaps in lightcurve data at critical viewing aspects, we were able to leverage our results to help limit the range of formation scenarios and the link to Phaethon in the context of non-gravitational forces and timescales associated with the physical evolution of the system. [less ▲]

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See detailP08.03 Combining PD-1/PD-L1 blockade and RANKL inhibitors to treat breast cancers unresponsive to standard therapy
Pilard, Charlotte ULiege; RONCARATI, Patrick ULiege; Hendrick, Elodie ULiege et al

in Journal for ImmunoTherapy of Cancer (2020, October 01), 8(Suppl 2), 50-51

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See detailEarly liver transplantation for severe alcoholic hepatitis not responding to medical treatment: results of the French-Belgian prospective study QuickTrans
Louvet, A; Labreuche, J; Moreno, C et al

in Hepatology (2020, October), 72(number 1 (suppl)), 4-5

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See detailLocal adaptation of bone micro-structure and canal network to tendon insertion investigated by image-based micro-FE simulations
Tits, Alexandra ULiege; Varga, Peter; Volders, Timothy ULiege et al

in Bone Reports (2020, October), 13

Tendons anchor to bone through a multi-material region called enthesis, showing several strategies to cope with the challenging task of joining dissimilar tissues. Less understood is whether bone ... [more ▼]

Tendons anchor to bone through a multi-material region called enthesis, showing several strategies to cope with the challenging task of joining dissimilar tissues. Less understood is whether bone microstructure also displays specific features to facilitate force transmission from tendon to bone. Such knowledge is of clinical relevance as local mechanical stresses play a crucial role in avulsion fractures and interface pathologies. Here we characterized the microstructure of bone close to tendon insertion in calcanei of adult rats (n=5) with micro-computed tomography (SkyScan, Bruker; 5 to 1.2 micrometer voxel size). After aligning the virtual bones along the main axes of inertia, we investigated a bony tuberosity connecting the Achilles tendon with the plantar fascia ligament. We performed a spatially resolved analysis of trabecular microstructure, indicating that trabecular network (BV/TV and anisotropy) is not significantly influenced by the tendon insertion (P = 0.69). Conversely, high resolution images revealed that bone beneath the attachment region exhibits a highly oriented canal network, aligned with the pulling direction of the tendon (P b 0.005). Image-based micro-finite element analysis was used to calculate stresses within the bone induced by tendon loading. Simulations highlighted a non-trivial stress pattern within the bone with high stresses mainly flowing within the tuberosity (27% higher than in the rest of the bone, P b 0.005). Our work suggests that not only the enthesis but also the underlying bone is well-adapted to accommodate tendon loading. [less ▲]

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See detailSMA: REGISTRIES, BIOMARKERS & OUTCOME MEASURES: P.187 Systematic literature review of the economic burden and economic evaluations in spinal muscular atrophy
Dangouloff, Tamara ULiege; Servais, Laurent ULiege; Hiligsmann, Mickaël ULiege

in Neuromuscular Disorders (2020, October)

New treatments in spinal muscular atrophy (SMA) have led to a complete change in the pattern in the use of health care resources in this disease. Through all over the world, the very high cost of ... [more ▼]

New treatments in spinal muscular atrophy (SMA) have led to a complete change in the pattern in the use of health care resources in this disease. Through all over the world, the very high cost of innovative medication has led to public debates largely expressed in mainstream medias. We have systematically reviewed studies evaluating the cost of SMA and economic evaluations of spinal muscular atrophy. The review was conducted according to PRISMA guidelines and included original articles published between January 1, 1998 and March 2020. Seven studies reporting the cost of SMA were identified. The average annual costs of untreated SMA1 (including early onset and SMA before one year), were relatively similar across the different studies, ranging from $106,000 to $140,000 per year. On the other hand, the costs for SMA 2, 3 and 4 were mainly presented together (ranging from $23,000 to $115,000), despite a high heterogenicity in clinical conditions leading to very different health care resource consumption. Five economic evaluations were published between 2017 and 2020 and included innovative disease modifying medications. Three assessed the cost-effectiveness of nusinersen against standards of care, one of them two treatments (nusinersen and zolgensma) against standards of care and one compared Nusinersen and Zolgensma. All studies used a decision-analytic model to assess the cost- effectiveness and are based on same clinical trials involving a limited number of patients. Due to the extremely high cost of treatment, the incremental cost-effectiveness ratio of drugs versus no treatment is generally above $200,000, leading to no cost-effective results. In conclusion, all studies converge to demonstrate the significant economic cost of SMA, especially SMA1, but a better evaluation of the cost related to other forms is needed. A few economic evaluations suggest that drugs delivered in post-symptomatic phase at current prices are actually not cost-effective at commonly accepted cost-effectiveness threshold. No economic evaluation of newborn screening has yet been conducted. [less ▲]

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See detailAre our Visions of the Future Development Realistic?
Pfennig, Andreas ULiege

in Chemie Ingenieur Technik (2020, September 24), 92(9), 1197

The Grand Challenges of Humanity lying ahead also require behavioral changes. Thus, it is important that appropriate awareness on the influence is created, which each individual actually has. This can be ... [more ▼]

The Grand Challenges of Humanity lying ahead also require behavioral changes. Thus, it is important that appropriate awareness on the influence is created, which each individual actually has. This can be achieved based on corresponding scenario simulations. Typically, the current scenarios for policymakers are generated with complex integrated assessment models (IAMs). Such complex simulations can fail to appropriately describe reality (H. Hasse, 2003: Thermodynamics of Reactive Separation. In: K. Sundmacher, A. Kienle (Eds.): Reactive Distillation Status and Future Directions. Wiley-VCH, Weinheim). It turns out, that major dependencies for future development can be described with global balances on materials and energy fluxes with only few assumptions. It was especially possible to include some of the major variables relevant for development of chemical industry like the variation between bio-based or CO2-based chemistry as well as including the option of direct air capture to obtain CO2 (DECHEMA, FutureCamp, 2019: Roadmap Chemie 2050, Auf dem Weg zu einer treibhausgasneutralen chemischen Industrie in Deutschland). Thus, the developed tool allows to question the published scenarios with respect to plausibility with unexpected outcome. The changes required in individual behavior are derived with a persuasive power similar to that of a limited carbon budget. [less ▲]

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See detailDisparities in access to oncology clinical trials in Europe in the period 2009-2019
Carneiro, Ana; Amaral, Teresa; Brandao, Mariana et al

in Annals of Oncology (2020, September 19)

Background: Clinical trials are essential for advancing cancer treatment. Yet, there is limited data on their distribution and access in Europe. To ascertain the extent of potential inequalities in access ... [more ▼]

Background: Clinical trials are essential for advancing cancer treatment. Yet, there is limited data on their distribution and access in Europe. To ascertain the extent of potential inequalities in access to clinical trials in Europe, we compared their distribution among European countries. Methods: The Clinicaltrials.gov database was searched for interventional clinical trials in adults with neoplasms. Available data from phase I-III trials between 06/2009 to 06/2019 in Europe were retrieved. We considered the number of clinical trials registered in each country and one “trial-entry” was defined as one trial/country. Results: In total, 18454 trial-entries were identified, of which 12% were phase I, 10% phase I/II, 32% phase II, 2% phase II/III and 44% phase III; 74% were industry-sponsored, 15% were academic and 11% were an academic/industry partnership. The number of trials per country varied from 2.48 in Central/Eastern Europe to 5.33/100 000 inhabitants in Northern Europe. The proportion of phase I-II trials was higher in the Southern and Western regions (13-15%) compared to Central/Eastern and Northern regions (4-9%). The number of trial-entries/100 000 inhabitants/country ranged from 0.14 (Albania) to 10.7 (Belgium). Between 2010 and 2018, the total number of trials per country in Europe increased by 33%. The increase in early-phase trials was larger (phase I-II, 61%) than in late-phase trials (phase II-III, 7%). Portugal, Ireland, Finland, Greece and Norway registered the largest percentage increase in early-phase trials, while Ireland, Spain, Norway, Italy and Belgium led the largest percentage increase in late-phase trials. Five countries dominated in terms of an increase in the absolute number of total trial-entries in both early- and late-phase trials: Spain (90/40), France (45/16), UK (45/13), Italy (38/19) and Belgium (35/12). During this period there was no significant variation in the distribution of industry and academic sponsored trials but an increase in industry/academic partnerships was observed (= 8%). Conclusions: The number of clinical trials varies greatly among European regions resulting in potential asymmetries in patients’ access to clinical trials. The disparities in access to oncology trials need to be addressed by all the stakeholders. [less ▲]

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See detailExpected medium and long term impact of the COVID-19 outbreak in oncology
JERUSALEM, Guy ULiege; ONESTI, Concetta Elisa ULiege; Generali, Daniele et al

in Annals of Oncology (2020, September 19)

Background: The ongoing SARS-CoV-2 pandemic and ensuing coronavirus disease (COVID-19) is challenging cancer care and services worldwide. Methods: A 95 items survey was distributed worldwide by 20 ... [more ▼]

Background: The ongoing SARS-CoV-2 pandemic and ensuing coronavirus disease (COVID-19) is challenging cancer care and services worldwide. Methods: A 95 items survey was distributed worldwide by 20 oncologists from 10 of the most affected countries in order to evaluate the impact on organization of oncological care. Results: 109 representatives from oncology centers in 18 countries (62.4% academic hospitals) filled out the survey (June 17 e July 14, 2020). A swab or gargle test is systematically performed before day care unit or overnight stay admissions in 27.5% and 58.7% of the centers, respectively. A local registry (64.2%) and systematic tracing (77.1%) of infected patients was organized in many centers. Treatment modalities mostly affected by the pandemic (cancellation/delay) were surgery (44.1%) and chemotherapy (25.7%). Earlier cessation of palliative treatment was observed in 32.1% of centers, and 64.2 % of participants agree that under-treatment is a major concern. At the pandemic peak, teleconsultations were performed for follow-up (94.5%), for oral therapy (92.7%), but also for patients receiving immunotherapy (57.8%) or chemotherapy (55%). Approximately 82% of participants estimate that they will continue to use telemedicine. Most participants reported more frequent use of virtual tumor boards (82%) and oncological team meetings (92%), but 45% disagree that virtual meetings are an acceptable alternative to live international meetings. Although 60.9% report reduced clinical activity during the pandemic peak, only 28.4% had an increased scientific activity. Only 18% of participants estimate that their wellbeing will not recover to previous levels by the end of the year; 63% indicate easily accessible psychological support for caregivers, but only 10% used or planned to use it. All clinical trial activities are or will soon be reactivated in 72.5% of the centers. Major study protocol violations/deviations were observed in 27.5% and significant reductions of clinical trial activities are expected by 37% of centers this year. Conclusions: COVID-19 has a major impact on organization of patient care, well-being of caregivers, continued medical education and clinical trial activities in oncology. [less ▲]

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See detailUnsupervised segmentation of indoor 3D point cloud: application to object-based classification
Poux, Florent ULiege; Mattes, Christian; Kobbelt, Leif

in International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2020, September 03), XLIV-4(W1-2020), 111-118

Abstract. Point cloud data of indoor scenes is primarily composed of planar-dominant elements. Automatic shape segmentation is thus valuable to avoid labour intensive labelling. This paper provides a ... [more ▼]

Abstract. Point cloud data of indoor scenes is primarily composed of planar-dominant elements. Automatic shape segmentation is thus valuable to avoid labour intensive labelling. This paper provides a fully unsupervised region growing segmentation approach for efficient clustering of massive 3D point clouds. Our contribution targets a low-level grouping beneficial to object-based classification. We argue that the use of relevant segments for object-based classification has the potential to perform better in terms of recognition accuracy, computing time and lowers the manual labelling time needed. However, fully unsupervised approaches are rare due to a lack of proper generalisation of user-defined parameters. We propose a self-learning heuristic process to define optimal parameters, and we validate our method on a large and richly annotated dataset (S3DIS) yielding 88.1\% average F1-score for object-based classification. It permits to automatically segment indoor point clouds with no prior knowledge at commercially viable performance and is the foundation for efficient indoor 3D modelling in cluttered point clouds. [less ▲]

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See detail3D Viewpoint Optimization of Topological Relationships: Application to 3D Cadastre for Visual Easement Validation
Neuville, Romain ULiege; Jacynthe, Pouliot; Billen, Roland ULiege

in ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2020, September 03), VI-4/W1-2020

Offering optimum 3D viewpoint to user can be attractive in relieving occlusion in 3D scene. This could be much relevant for the visualization of 3D cadastral systems since they constitute complex datasets ... [more ▼]

Offering optimum 3D viewpoint to user can be attractive in relieving occlusion in 3D scene. This could be much relevant for the visualization of 3D cadastral systems since they constitute complex datasets including both physical and legal objects while users are operating a number of visual tasks that require precise outlook. However, 3D viewpoint usability has yet to be evaluated to demonstrate its relevance in accomplishing given end user’s visual tasks. Hence, in this research project, the focus is set on visual identification of 3D topological relationships (disjoint and overlap) as it is one of the main users’ requirements in 3D cadastre. To this end, this paper addresses this issue using a virtual 3D model of the Planetarium Rio Tinto Alcan (Montreal city) in which property issues take place, especially regarding the easement validation procedure. Empirical tests have then been administrated in the form of interviews using an online questionnaire with university students who will specifically address such issues in their professional career. The results show that a 3D viewpoint that maximizes 3D disjoined or overlapped geometric objects’ view area within the viewport significantly outperforms traditional combined software points of view in visually identifying 3D topological relationship. This paper also suggests that user’s inexperience in 3D cadastre reduces visual task efficiency when visually identifying 3D topological relationship among overlapped geometric objects. Eventually, this study opens up new perspectives on 3D topological relationships modeling and visualization. [less ▲]

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See detailThéâtre, tragédie et raison pure. Sur le §52 de la Critique de la faculté de juger de Kant
Dubouclez, Olivier ULiege

in Études de Lettres (2020, September)

Kant traite du théâtre à la fin de la première partie de la Critique de la faculté de juger (1790), dans le §52 qui est consacré à «l’association des beaux-arts». Il y met en lumière une double précarité ... [more ▼]

Kant traite du théâtre à la fin de la première partie de la Critique de la faculté de juger (1790), dans le §52 qui est consacré à «l’association des beaux-arts». Il y met en lumière une double précarité: celle du théâtre conçu comme éloquence (ce rapprochement le tirant du côté du simple divertissement) et celle de la tragédie, genre sublime, constamment menacée d’être réduite à une simple exaltation des forces vitales. Kant réfléchit alors sur les conditions historiques du surgissement du sentiment tragique: sa sublimité dépend en effet d’une double condition, subjective (du côté du spectateur comme sujet moral) et de l’artiste (en tant qu’il est capable de présenter l’infini), au sein d’un devenir culturel où s’accomplit la moralisation de l’être humain. [less ▲]

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See detailTool and Workflow for Systematic Design of Reactive Extraction for Separation and Purification of Valuable Components
Benkoussas, Hana ULiege; Leleu, David ULiege; Satpathy, Swagatika ULiege et al

in Chemie Ingenieur Technik (2020, September)

With reactive extraction, separation as well as purification can be realized for a wide palette of applications ranging from phosphorous recovery from sewage sludge to separation of rare-earth metals from ... [more ▼]

With reactive extraction, separation as well as purification can be realized for a wide palette of applications ranging from phosphorous recovery from sewage sludge to separation of rare-earth metals from electronic waste in the context of urban mining. Goal of process design then has to be to find an optimal selection of reactive ex-tractant, diluent, possible additional components, as well as all process parameters. This requires a deep understanding of the chemistry of the underlying complexations as well as engineering expertise on extraction-process as well as equipment design. To solve this design task a tool was developed based on cascaded option trees (A. Bednarz, B. Rüngeler, A. Pfennig, Chem. Ing. Tech. 2014, 86(5), 611-620, DOI: 10.1002/cite.201300115), which combines the expertise from both sciences. The process design is on the one hand supported by a prototypic work flow and on the other hand by systematically structured and quantitative information on the underly-ing thermodynamics. The combination of these building blocks constitutes a design tool, which can guide through the systematic design of a reactive-extraction process for solving any of the separation tasks encountered in the areas mentioned in the introduction. [less ▲]

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See detailSELF-LEARNING ONTOLOGY FOR INSTANCE SEGMENTATION OF 3D INDOOR POINT CLOUD
Poux, Florent ULiege; Ponciano, Jean-Jacques

in International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2020, August 12), XLIII(B2), 309316

Automation in point cloud data processing is central for efficient knowledge discovery. In this paper, we propose an instance segmentation framework for indoor buildings datasets. The process is built on ... [more ▼]

Automation in point cloud data processing is central for efficient knowledge discovery. In this paper, we propose an instance segmentation framework for indoor buildings datasets. The process is built on an unsupervised segmentation followed by an ontology-based classification reinforced by self-learning. We use both shape-based features that only leverages the raw X, Y, Z attributes as well as relationship and topology between voxel entities to obtain a 3D structural connectivity feature describing the point cloud. These are then used through a planar-based unsupervised segmentation to create relevant clusters constituting the input of the ontology of classification. Guided by semantic descriptions, the object characteristics are modelled in an ontology through OWL2 and SPARQL to permit structural elements classification in an interoperable fashion. The process benefits from a self-learning procedure that improves the object description iteratively in a fully autonomous fashion. Finally, we benchmark the approach against several deep-learning methods on the S3DIS dataset. We highlight full automation, good performances, easy-integration and a precision of 99.99% for planar-dominant classes outperforming state-of-the-art deep learning. [less ▲]

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See detailMARKER-LESS MOBILE AUGMENTED REALITY APPLICATION FOR MASSIVE 3D POINT CLOUDS AND SEMANTICS
Kharroubi, Abderrazzaq ULiege; Billen, Roland ULiege; Poux, Florent ULiege

in International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2020, August 12), XLIII(B2), 255261

Mobile Augmented Reality (MAR) attracts significant research and development efforts from both the industry and academia, but rarely integrate massive 3D dataset’s interactions. The emergence of dedicated ... [more ▼]

Mobile Augmented Reality (MAR) attracts significant research and development efforts from both the industry and academia, but rarely integrate massive 3D dataset’s interactions. The emergence of dedicated AR devices and powerful Software Development Kit (ARCore for android and ARKit for iOS) improves performance on mobile devices (Smartphones and tablets). This is aided by new sensor integration and advances in computer vision that fuels the development of MAR. In this paper, we propose a direct integration of massive 3D point clouds with semantics in a web-based marker-less mobile Augmented Reality (AR) application for real-time visualization. We specifically investigate challenges linked to point cloud data structure and semantic injection. Our solution consolidates some of the overarching principles of AR, of which pose estimation, registration and 3D tracking. The developed AR system is tested on mobile phones web-browsers providing clear insights on the performance of the system. Promising results highlight a number of frame per second varying between 27 and 60 for a real-time point budget of 4.3 million points. The point cloud tested is composed of 29 million points and shows how our indexation strategy permits the integration of massive point clouds aiming at the point budget. The results also gives research directions concerning the dependence and delay related to the quality of the network connection, and the battery consumption since portable sensors are used all the time. [less ▲]

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See detailAutomatic 3D Buildings Compact Reconstruction from LiDAR point clouds
Nys, Gilles-Antoine ULiege; Billen, Roland ULiege; Poux, Florent ULiege

in International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2020, August 12), (XLIII-B2-2020), 473-478

Point clouds generated from aerial LiDAR and photogrammetric techniques are great ways to obtain valuable spatial insights over large scale. However, their nature hinders the direct extraction and sharing ... [more ▼]

Point clouds generated from aerial LiDAR and photogrammetric techniques are great ways to obtain valuable spatial insights over large scale. However, their nature hinders the direct extraction and sharing of underlying information. The generation of consistent large-scale 3D city models from this real-world data is a major challenge. Specifically, the integration in workflows usable by decision-making scenarios demands that the data is structured, rich and exchangeable. CityGML permits new advances in terms of interoperable endeavour to use city models in a collaborative way. Efforts have led to render good-looking digital twins of cities but few of them take into account their potential use in finite elements simulations (wind, floods, heat radiation model, etc.). In this paper, we target the automatic reconstruction of consistent 3D city buildings highlighting closed solids, coherent surface junctions, perfect snapping of vertices, etc. It specifically investigates the topological and geometrical consistency of generated models from aerial LiDAR point cloud, formatted following the CityJSON specifications. These models are then usable to store relevant information and provides geometries usable within complex computations such as computational fluid dynamics, free of local inconsistencies (e.g. holes and unclosed solids). [less ▲]

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See detailPower Factor Improvement by Active Distribution Networks During Voltage Emergency Situations
Pabon Ospina, Luis David; Van Cutsem, Thierry ULiege

in Electric Power Systems Research (2020, August)

As more Distributed Generation Units (DGUs) are integrated into medium–voltage grids, the interaction between transmission and distribution networks plays a higher role in power system security. The ... [more ▼]

As more Distributed Generation Units (DGUs) are integrated into medium–voltage grids, the interaction between transmission and distribution networks plays a higher role in power system security. The contribution of the so-called Active Distribution Networks (ADNs) to system stability is expected to become more and more significant. This paper focuses on long-term voltage stability issues and shows that, contrary to what might be expected, a mere reactive power injection by DGUs has detrimental effects on system stability and might bring along counterproductive effects that precipitate voltage instability and collapse. Hence, an alternative control scheme for power factor improvement by ADNs during voltage emergency situations is proposed. The power factor is measured at the point of common coupling between transmission and distribution networks. The controller enhances system stability and eliminates the identified counterproductive effects. The conclusions are derived from time-domain simulations of a very simple, but concept-friendly, 5-bus system. [less ▲]

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See detailHepatitis E virus genotype 3 subtype dependent clinical outcomes in Belgium 2010-2018
Peeters, M; De Somer, T; Klamer, S et al

in Journal of Hepatology (2020, August), 73

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See detailEarly liver transplantation for severe alcoholic hepatitis not responding to medical treatment: results of the French-Belgian prospective study QuickTrans
Louvet, A; Labreuche, J; Moreno, C et al

in Journal of Hepatology (2020, August), 73

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See detailStochastic and deterministic formulations for capacity firming nominations
Dumas, Jonathan ULiege; Cornélusse, Bertrand ULiege; Giannitrapani, Antonello et al

in International Conference on Probabilistic Methods Applied to Power Systems (2020, August)

This paper addresses the energy management of a grid-connected photovoltaic plant coupled with a battery energy storage device, within the capacity firming specifications of the French Energy Regulatory ... [more ▼]

This paper addresses the energy management of a grid-connected photovoltaic plant coupled with a battery energy storage device, within the capacity firming specifications of the French Energy Regulatory Commission. The paper contributions are positioned in the continuity of the studies adopting stochastic models for optimizing the bids of renewable energy sources in a day-ahead market by considering a storage device. The proposed deterministic and stochastic approaches are optimization problems formulated as quadratic problems with linear constraints. The case study is a real microgrid with PV production monitored on site. The results demonstrate the validity of the stochastic formulation by using an ideal predictor that produces unbiased PV scenarios. [less ▲]

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See detailInsulin Resistance in ICU Patients: Women Have Stronger Metabolic Response
Uyttendaele, Vincent ULiege; Knopp, Jennifer L.; Gottlieb, Rebecca et al

in IFAC-PapersOnLine (2020, July)

Glycaemic control (GC) has been associated with improved outcomes in critically ill patients. However, inter- and intra- patient metabolic variability significantly increase the risk of hypoglycaemia when ... [more ▼]

Glycaemic control (GC) has been associated with improved outcomes in critically ill patients. However, inter- and intra- patient metabolic variability significantly increase the risk of hypoglycaemia when using insulin to control glycaemia. Model-based protocols often identify key physiological parameters from patient data, and demonstrated safe and effective GC. Based on recent studies showing gender difference in insulin secretion, this study uses retrospective data to identify whether there exists a difference in sexes in metabolic stress response, and thus in how personalised GC is given. Retrospective data from 145 ICU patients under GC who started GC in the first 12 hours of ICU stay are used. Insulin sensitivity (SI) is identified hourly, as well as the hour-to-hour percentage change in SI (%ΔSI). Differences between males and females SI and %ΔSI over 6-h blocks are compared using hypothesis and equivalence testing. A difference in SI levels would suggest a difference in metabolic stress response to insult, while a difference in %ΔSI levels would suggest a resulting difference in the difficulty to control. Results show females are significantly more insulin resistant than males and not equivalent, suggesting stronger stress response to insult induced stress. Metabolic variability is equivalent in both groups, advocating GC safety and efficacy should be similar between males and females, despite potential higher insulin rates required for females. This study is the first to suggest potential gender differences in the metabolic stress response. [less ▲]

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See detailTranslating A Risk-Based Glycaemic Control Framework for Critically Ill Patients: STAR-Liège
Uyttendaele, Vincent ULiege; Knopp, Jennifer L.; PIROTTE, Marc ULiege et al

in IFAC-PapersOnLine (2020, July)

Glycaemic control (GC) in the intensive care unit (ICU) has been widely debated over the last 20 years. While many studies showed benefits, many others failed to replicate the results, blaming the ... [more ▼]

Glycaemic control (GC) in the intensive care unit (ICU) has been widely debated over the last 20 years. While many studies showed benefits, many others failed to replicate the results, blaming the increased related risk of hypoglycaemia. Current ICU guidelines thus often suggest higher glycaemic target ranges, led by the fear of hypoglycaemia – permissive hyperglycaemia. However, recent studies have shown improved safety and performance in GC outcome, using model-based computerised methods. The Stochastic-Targeted (STAR) framework is a patient-specific risk-based dosing protocol modulating insulin and nutrition. This study presents recent intermediate results of the STAR-Liège clinical trial, targeting 4.4-8.0 mmol/L glycaemic band. Clinical data from patients controlled under STAR and STAR insulin only (STAR-IO) are compared to retrospective data under the standard protocol (SP), targeting higher 5.6-8.3 mmol/L glycaemic ranges. Overall, STAR performance was significantly higher (88% blood glucose measurements in the 4.4-8.0 mmol/L or 80-145 mg/dL target band) compared to STAR-IO (78%) and SP (55%). Incidence of hypoglycaemia was similar (1% below target), while hyperglycaemia was much higher for SP (31% above target) compared to STAR (9%) and STAR-IO (11%). The resulting lower median blood glucose (BG) levels in STAR (6.5 mmol/L), compared to STAR-IO (6.7 mmol/L) and SP (7.7 mmol/L), was achieved with less variability, but required higher clinical workload for STAR (12 measurements per day) compared to SP (7 measurements per day). Compliance to protocol was higher for STAR (98%) compared to STAR-IO (90%) and SP (79%). Although targeting lower glycaemic ranges, STAR provided better GC compared to the SP. Typically, the full version of STAR also modulating nutrition, was able to better control extremely insulin resistant patients, further improving glycaemic control results. The results of this clinical trial indicate the capability to provide the safe, effective control for all patients required to improve outcomes. [less ▲]

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See detailEfficacy and safety of an intra-articular injection of JTA-004, a novel enhanced protein solution, in knee osteoarthritis pain: a randomized, double-blind controlled phase II/III study
Bettonville, M; Leon, M; Margaux, J et al

in Annals of the Rheumatic Diseases (2020, June), 79(Supplement 1), 798

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See detailMultimodal and multiview distillation for real-time player detection on a football field
Cioppa, Anthony ULiege; Deliège, Adrien ULiege; Noor, Ul Huda et al

in IEEE Conference on Computer Vision and Pattern Recognition. Proceedings (2020, June)

Monitoring the occupancy of public sports facilities is essential to assess their use and to motivate their construction in new places. In the case of a football field, the area to cover is large, thus ... [more ▼]

Monitoring the occupancy of public sports facilities is essential to assess their use and to motivate their construction in new places. In the case of a football field, the area to cover is large, thus several regular cameras should be used, which makes the setup expensive and complex. As an alternative, we developed a system that detects players from a unique cheap and wide-angle fisheye camera assisted by a single narrow-angle thermal camera. In this work, we train a network in a knowledge distillation approach in which the student and the teacher have different modalities and a different view of the same scene. In particular, we design a custom data augmentation combined with a motion detection algorithm to handle the training in the region of the fisheye camera not covered by the thermal one. We show that our solution is effective in detecting players on the whole field filmed by the fisheye camera. We evaluate it quantitatively and qualitatively in the case of an online distillation, where the student detects players in real time while being continuously adapted to the latest video conditions. [less ▲]

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See detailConsensus statement on intra-articular injections of platelet-rich plasma for the management of knee osteoarthritis
Eymard, F; Ornetti, P; Maillet, J et al

in Annals of the Rheumatic Diseases (2020, June), 79(Supplement 1), 1738

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See detailA Context-Aware Loss Function for Action Spotting in Soccer Videos
Cioppa, Anthony ULiege; Deliège, Adrien ULiege; Giancola, Silvio et al

in IEEE Conference on Computer Vision and Pattern Recognition. Proceedings (2020, June)

In video understanding, action spotting consists in temporally localizing human-induced events annotated with single timestamps. In this paper, we propose a novel loss function that specifically considers ... [more ▼]

In video understanding, action spotting consists in temporally localizing human-induced events annotated with single timestamps. In this paper, we propose a novel loss function that specifically considers the temporal context naturally present around each action, rather than focusing on the single annotated frame to spot. We benchmark our loss on a large dataset of soccer videos, SoccerNet, and achieve an improvement of 12.8% over the baseline. We show the generalization capability of our loss for generic activity proposals and detection on ActivityNet, by spotting the beginning and the end of each activity. Furthermore, we provide an extended ablation study and display challenging cases for action spotting in soccer videos. Finally, we qualitatively illustrate how our loss induces a precise temporal understanding of actions and show how such semantic knowledge can be used for automatic highlights generation. [less ▲]

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See detailA multicomponent medication promotes chondrogenesis and reduces MMP-13 in primary articular chondrocytes from knee osteoarthritis patients in vitro
Sanchez, Christelle ULiege; Hemmer, Kathrin; Kroemmelbein, Natascha et al

in Annals of the Rheumatic Diseases (2020, June), 79(Suppl 1), 1336

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See detailBoswellia serrata extract and curcumin increase GDF15 production by human primary osteoarthritis chondrocytes: a new mechanism of action
Sanchez, Christelle ULiege; Zappia, Jérémie ULiege; Dierckxsens, Yvan et al

in Annals of the Rheumatic Diseases (2020, June), 79(Suppl 1), 1336-1337

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See detailAn oleuropein-based dietary supplement improves joint functionality in older people with hugh knee joint pain
Horcajada, Marie-Noelle; Beaumont, M; Sauvageot, N et al

in Annals of the Rheumatic Diseases (2020, June), 79(Suppl 1), 930

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See detailSUN-LB46 Differences in IGF-I Concentrations Between European and US Populations - Consequences for Reference Intervals
Bidlingmaier, Martin; Valcour, Andre; Chun, Kelly Y. et al

in Journal of the Endocrine Society (2020, June), 4(Supplement_1), 1092-1093

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See detailHow to represent 3D Data?
Poux, Florent ULiege

in Towards Data Science (2020, May 11)

The 3D datasets in our computerized ecosystem — of which an increasing number comes directly from reality capture devices — are found in different forms that vary in both the structure and the properties ... [more ▼]

The 3D datasets in our computerized ecosystem — of which an increasing number comes directly from reality capture devices — are found in different forms that vary in both the structure and the properties. Interestingly, they can be somehow mapped with success to point clouds thanks to its canonical nature. This article gives you the main 3D data representations modes to choose from when bindings point clouds to your application [less ▲]

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See detail« Leurs propos le tesmoignent assez » Le discours rapporté par voie épistolaire, arme de la Ligue catholique parisienne (1585-1594)
Goderniaux, Alexandre ULiege

in Ouvroir Litt&Arts (2020, May), 13

De 1585 à 1594, la Ligue parisienne imprime près d’une centaine de lettres rapportant les propos de nombreux acteurs dans des situations d’élocutions particulièrement protéiformes. Cette enquête étudie ... [more ▼]

De 1585 à 1594, la Ligue parisienne imprime près d’une centaine de lettres rapportant les propos de nombreux acteurs dans des situations d’élocutions particulièrement protéiformes. Cette enquête étudie les pratiques discursives par lesquelles le discours rapporté en contexte épistolaire a été instrumentalisé par les ultra-catholiques dans le cadre de cette guerre des libelles. Recourant largement à l’étude de cas, elle analyse comment les libellistes ont concrètement fait participer la citation des propos d’autrui à un vaste système discursif, notamment via la mise en scène de son origine et de son inclusion dans un échange privé, via son interprétation comme témoignage à charge contre les ennemis des catholiques, ou encore via des éléments de réflexion émis par les polémistes à propos du discours lui-même. Ce faisant, elle met en lumière la diversité des pratiques auxquelles les libellistes ligueurs ont recours afin de faire du discours en contexte épistolaire un argument au service de leurs revendications politiques. [less ▲]

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See detailMicrostructure and properties of SLM AlSi10Mg: Understanding the influence of the local thermal history
Mertens, Anne ULiege; Delahaye, Jocelyn ULiege; Dedry, Olivier ULiege et al

in Procedia Manufacturing (2020, April 26), 47

Selective Laser Melting (SLM) is an Additive Manufacturing technique that is widely used to produce AlSi10Mg parts with a good strength-to-weight ratio. Indeed, strongly refined microstructures are ... [more ▼]

Selective Laser Melting (SLM) is an Additive Manufacturing technique that is widely used to produce AlSi10Mg parts with a good strength-to-weight ratio. Indeed, strongly refined microstructures are obtained due to the ultra-fast cooling rates reached in this process, conferring high strength to the parts, even in the as-built state. However, microstructural heterogeneities at the scale of the melt pool may exert a detrimental influence on the mechanical properties e.g. by causing a loss in ductility. This study thus aims at a better understanding of the influence of the local thermal history on local variations of microstructure and mechanical properties. Microscopy (i.e. SEM+EDS) and nanoindentation have been combined to reach a detailed knowledge of the local microstructure and properties. In particular, the solute Si content in the -Al matrix, the volume fraction and the size of Si precipitates have been quantified by microscopy analysis. These local microstructural parameters are correlated with the matrix hardness as revealed by nanoindentation. Finally, the results of this detailed characterization are linked with the local thermal history that is approached in two different ways i.e. (i) an analytical description of thermal gradients inside the melt pool based on Rosenthal’s and Matyja’s equations and (ii) a simple Finite Element model for the deposition of a few layers in the SLM process. [less ▲]

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See detailThermal Analysis of Solidifying Steel Shell in Continuous Casting Process
Tran, Hoang Son ULiege; Castiaux, Etienne; Habraken, Anne ULiege

in Procedia Manufacturing (2020, April), 47

A finite element simulation of the steel shell formation in continuous casting has been developed. The current research is focused on the solidification of molten steel during the initial stages of the ... [more ▼]

A finite element simulation of the steel shell formation in continuous casting has been developed. The current research is focused on the solidification of molten steel during the initial stages of the mould cooling. The model allows predicting the temperature field throughout the process: temperature gradient, solidification front, cooling rates. In stationary state, the prediction of shell thickness reasonably agrees with analytical models and experimental observations. The simulation tool is used to study the alteration of the mould thermal field in case of sticking defects encountered in industrial practice. A numerical analysis increases the understanding of the phenomena. [less ▲]

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See detailAn oleuropein-based dietary supplement improves joint functionality in older people with high knee joint pain
Horcajada, M-N; Beaumont, M; Sauvageot, N et al

in Osteoarthritis and Cartilage (2020, April), 28(Suppl 1), 472-3

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See detailA multicomponent medication promotes chondrogenesis and reduces MMP-13 in primary articular chondrocytes from knee osteoarthritis patients in vitro
Sanchez, Christelle ULiege; Hemmer, Kathrin; Krommelbein, Natascha et al

in Osteoarthritis and Cartilage (2020, April), 28(Suppl 1), 106-107

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See detailBoswellia serrata extract and curcumin increase GDF15 production by human primary osteoarthritis chondrocytes: a new mechanism of action
Sanchez, Christelle ULiege; Zappia, Jérémie ULiege; Dierckxsens, Yvan et al

in Osteoarthritis and Cartilage (2020, April), 28(Suppl 1), 120

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See detailCartilage biomarkers S-COLL2-1 and S-COLL2-1NO2 are helpful in identifying knee osteoarthritis patients at risk of disease worsening
Henrotin, Yves ULiege; Hick, Anne-Christine; Labasse, Alain et al

in Osteoarthritis and Cartilage (2020, April), 28(Suppl 1), 327-28

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See detailUn oratoire du Xe siècle sur le site du Rocher du Vieux-Château à Pont-de-Bonne (Lg)
Delye, Emmanuel ULiege; Wymmersch, Guillaume ULiege

in Archaeologia Mediaevalis. Archéologie du Moyen Âge et de Temps Modernes dans les trois régions belges et les pays limitrophes (2020, March 13), 43

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See detailHepatitis E virus genotype 3 subtype dependent clinical outcomes in Belgium 2010-2018
De Somer, T; Peeters, M; Klamer, S et al

in Acta Gastro-Enterologica Belgica (2020, March), 83(1), 12

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See detailApsidal motion in the massive binary HD 152248
Rosu, Sophie ULiege; Rauw, Grégor ULiege; Gosset, Eric ULiege et al

in Contributions of the Astronomical Observatory Skalnaté Pleso (2020, March), 50(2), 624-626

The eccentric massive binary HD 152248, hosting two very similar O7.5 III(f) stars, is the most emblematic eclipsing O-star binary in the very young and rich open cluster NGC 6231. Measuring the rate of ... [more ▼]

The eccentric massive binary HD 152248, hosting two very similar O7.5 III(f) stars, is the most emblematic eclipsing O-star binary in the very young and rich open cluster NGC 6231. Measuring the rate of apsidal motion in such a binary system gives insight into the internal structure and evolutionary state of the stars composing it. [less ▲]

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See detailE.thesaurus :L'orfèvrerie à l'épreuve de la modélisation 3D - Valorisation, médiation et exploitation scientifique d'oeuvres médiévales
Gil, Marc; Hallot, Pierre ULiege

in HAL Archives ouvertes (2020, February 24), 02488959

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See detailFirst steps towards online Personal Dosimetry Using Computational Methods in Interventional Radiology: operator’s position tracking and simulation input generation
Abdelrahman, Mahmoud Eid Mahmoud ULiege; Lombardo, Pasquale; Vanhavere, Filip et al

in Radiation Physics and Chemistry (2020, January 16)

Introduction <br />With this work we present an innovative system for calculating occupational doses, as it is now being developed within the PODIUM (Personal Online DosImetry Using computational Methods ... [more ▼]

Introduction <br />With this work we present an innovative system for calculating occupational doses, as it is now being developed within the PODIUM (Personal Online DosImetry Using computational Methods) project. Individual monitoring of workers is essential to follow up regulatory dose limits and to apply the ALARA principle. However, current personal dosimeters are subject to large uncertainties, especially in non-homogeneous fields, like those found interventional radiology/cardiology. Workers in these fields also need to wear several dosimeters (extremity, eye lens, above/below apron), which causes practical problems. As the capabilities of computational methods are increasing exponentially, it will become feasible to use pure computations to calculate doses in place of physical dosimeters. <br /> <br />Methods <br />In our concept system, operational and protection quantities are calculated by fast Monte Carlo methods. Our dose calculation accounts for the real radiation field (including fluence, energy and angular distributions) and for the relative position of different body parts of the worker. The real movements of exposed workers are captured using depth cameras. This information is translated to a flexible anthropomorphic phantom, and then in Monte-Carlo simulations. For the moment this is done off-line, after the procedure is finished, and the parameters of the procedure are collected. <br /> <br />Results <br />For validating our system, we performed tests in interventional radiology (IR) rooms. In total, we followed 15 procedures in Cath-labs at UZ-VUB and CHU- Liège. An accurate analysis of the staff position was performed, and as a first step, we compared simulated Hp(10) and measured Hp(10) with electronic personal dosimeter (EPD) during an angiography procedure for some of these procedures. The results showed good agreement between the calculated doses and the ones measured by the EPD dosimeter. <br /> <br />Conclusions <br />With this work, we show that simulating worker doses based on tracking systems and flexible phantoms is possible. This method has big advantages in interventional radiology workplaces where the fields are non-homogeneous and doses to staff can be relatively high. This method can also help in ALARA applications and for education and training. [less ▲]

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See detailRECYCLING FINE PARTICLES FROM CONSTRUCTION AND DEMOLITION WASTES: CHARACTERIZATION AND EFFECTS ON CONCRETE PERFORMANCES
Courard, Luc ULiege; Bouarroudj, Mohamed Elkarim ULiege; Colman, Charlotte ULiege et al

in International Journal of Minerals, Metallurgy and Materials (2020)

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See detailDietary acrylamide and incident osteoporotic fractures: an 8-year longitudinal cohort study.
Veronese, N.; Cacco, C.; Smith, L. et al

in Osteoporosis International (2020), 31(S1), 383

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See detailCost-effectiveness of FRAX® based intervention tresholds for management of osteoporosis in Singaporean women
Chandran, M.; Ganesan, G.; Tan, K.B. et al

in Osteoporosis International (2020), 31(S1), 459

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See detailAn updated systematic review of cost-effectiveness analysis of drugs for osteoporosis
Li, N.; Cornelissen, D.; Silverman, S. et al

in Osteoporosis International (2020), 31(S1), 491

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See detailImproved statistical methods for monitoring knee osteoarthritis disease progression.
Parsons, C.M.; Judge, A.; Meyer, R. et al

in Osteoporosis International (2020), 31(S1), 524

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See detailPET-[18F]UCB-H for assessing synaptic density in FTD
Salmon, Eric ULiege; Bahri, Mohamed Ali ULiege; Plenevaux, Alain ULiege et al

in Alzheimer's and Dementia: the Journal of the Alzheimer's Association (2020), 16(S4), 037156

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