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See detailFeasibility study of low-carbon ammonia and steel production in Europe
Hoxha, Jean-Luc ULiege; Caspar, Mathieu; Donceel, Alexis et al

in Eceee Industrial Summer Study Proceedings (in press)

As stipulated in the Paris Agreement, greenhouse gas emissions have to be reduced in order to maintain the global warming well below 2°C. Moreover, the European Union committed to become carbon neutral by ... [more ▼]

As stipulated in the Paris Agreement, greenhouse gas emissions have to be reduced in order to maintain the global warming well below 2°C. Moreover, the European Union committed to become carbon neutral by 2050. This will require shifting industrial production currently based on fossil energies towards the use of renewable energies. The present article considers two conceptual industrial processes that may operate in Europe with low carbon emissions through the use of green hydrogen. The studied processes are projections of the production of ammonia and steel in the 2030s. Hydrogen is assumed to be produced by water electrolysis with Proton Exchange Membrane electrolysers. The purpose of this paper being to evaluate the feasibility of such processes, it is assumed that the electricity required by the processes is entirely provided by renewable energies, in order to focus only on the challenges directly related to the ammonia and steelmaking plants. For the same reason, the prices are estimated in 2030 and not later, to avoid too uncertain costs assumptions, even if a complete supply by renewable energies may be unrealistic at that moment. Based on current industrial sectors of both ammonia and steel productions, a detailed modelling of the two decarbonised processes in Aspen Plus software is carried out and an economic analysis is also presented to prove the feasibility of these processes [less ▲]

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See detailRegards sur la néologie wallonne aujourd’hui. État des lieux et questionnements pour aujourd’hui et pour demain
Balthazard, Matthieu ULiege

in Langues et Linguistique (in press)

We first present the Belgian-Romance linguistic situation (1), and then propose an overview of the four centers in which neologisms appear in Wallonia. In the two first instances, which we call in vivo ... [more ▼]

We first present the Belgian-Romance linguistic situation (1), and then propose an overview of the four centers in which neologisms appear in Wallonia. In the two first instances, which we call in vivo, neologisms are created by Walloon speakers and message writers. In the two last ones, which we call in vitro, the words are elaborated by the "refondeurs" of Walloon or created during subsidized contests dedicated to neologisms. In this overview, we describe these instances externally (general presentation, organization, media...) and internally (principles of lexical creation at work, etc.) (2). Finally, we examine the links between neology, survival of dialects and standardization. In a context of disappearance of dialects and in a perspective of preservation of these, neology drives us to think about standardization and the ideological and practical questions underlying it (3). [less ▲]

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See detailN, Fe single-doped and N-Fe co-doped TiO2 powders and films increasing photoactivity under visible light
Alié, Christelle ULiege; Caucheteux, Joachim; Douven, Sigrid et al

in Springer Series in Materials Science (in press)

This study aims to develop an eco-friendly and efficient photocatalytic coat-ing, active under a cost-effective visible LED system for the removal of or-ganic pollutants. An aqueous sol-gel process has ... [more ▼]

This study aims to develop an eco-friendly and efficient photocatalytic coat-ing, active under a cost-effective visible LED system for the removal of or-ganic pollutants. An aqueous sol-gel process has been used to produce N or Fe single-doped TiO2 photocatalysts as well as N-Fe co-doped TiO2 catalysts to extend its activity in the visible region. The physico-chemical properties of those catalysts were characterized by X-ray diffraction and diffuse reflec-tance spectroscopy and compared to commercial Evonik P25 TiO2. The use of dopants (N or Fe) extends the activity of TiO2 towards visible range. The photocatalytic activity of the undoped and doped catalysts has been studied by evaluating the degradation of the p-nitrophenol under visible light ( > 395 nm). Results show the increase of the p-nitrophenol degradation under visible light for all photocatalysts compared to undoped of commercial P25 TiO2, with the best results for the N-Fe co-doped TiO2 catalysts. Colloids prepared from these powders were spray-coated onto stainless steel sub-strates. After a large number of optimizations of the number of layers, of the roughness of the films, of the operating conditions of the spray-coating, a complete degradation of p-nitrophenol was obtained in 4 h at 18 °C with the TiO2-based coating doped with 43%mol of nitrogen and 0.25%mol of iron, and having an average thickness around 2 µm. [less ▲]

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See detailLe 'Receuil de Testes de caractere & de Charges dessinées par Leonard de Vinci' d'Anne-Claude de Caylus et Pierre-Jean Mariette (1730)
Fagnart, Laure ULiege

in Mélanges de l'École Française de Rome. Italie et Méditérranée (in press)

En 1730, paraît l’un des premiers textes de Pierre-Jean Mariette. Il s’agit de la Lettre sur Leonard de Vinci, suivi d’un Catalogue des pieces qui ont este gravées d’après les Tableaux ou Dessins de ... [more ▼]

En 1730, paraît l’un des premiers textes de Pierre-Jean Mariette. Il s’agit de la Lettre sur Leonard de Vinci, suivi d’un Catalogue des pieces qui ont este gravées d’après les Tableaux ou Dessins de Leonard de Vinci, qu’il publie en introduction au Recueil de Testes de caractere & de Charges dessinées par Leonard de Vinci Florentin et gravées par M. le Cte de Caylus. Le texte entend fournir aux connaisseurs des outils pour parler de peinture « pertinemment ». L’expert ne s’arrête donc guère sur la biographie du maître ; il cherche plutôt à caractériser son travail. Une démarche analogue caractérise le catalogue des (rares) estampes qui traduisent en gravure les compositions de Léonard. Outre des considérations liées aux techniques et aux lieux de conservation des œuvres reproduites, Mariette s’attache à distinguer ce qui relève de la « manière » du maître florentin de ce qui appartient à celle du graveur. [less ▲]

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See detailTruncated Marginal Neural Ratio Estimation
Kurt Miller, Benjamin; Cole, Alex; Forré, Patrick et al

in Advances in Neural Information Processing Systems (2021, December)

Parametric stochastic simulators are ubiquitous in science, often featuring high-dimensional input parameters and/or an intractable likelihood. Performing Bayesian parameter inference in this context can ... [more ▼]

Parametric stochastic simulators are ubiquitous in science, often featuring high-dimensional input parameters and/or an intractable likelihood. Performing Bayesian parameter inference in this context can be challenging. We present a neural simulator-based inference algorithm which simultaneously offers simulation efficiency and fast empirical posterior testability, which is unique among modern algorithms. Our approach is simulation efficient by simultaneously estimating low-dimensional marginal posteriors instead of the joint posterior and by proposing simulations targeted to an observation of interest via a prior suitably truncated by an indicator function. Furthermore, by estimating a locally amortized posterior our algorithm enables efficient empirical tests of the robustness of the inference results. Such tests are important for sanity-checking inference in real-world applications, which do not feature a known ground truth. We perform experiments on a marginalized version of the simulation-based inference benchmark and two complex and narrow posteriors, highlighting the simulator efficiency of our algorithm as well as the quality of the estimated marginal posteriors. Implementation on GitHub. [less ▲]

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See detailHNPE: Leveraging Global Parameters for Neural Posterior Estimation
Rodrigues, Pedro; Moreau, Thomas; Louppe, Gilles ULiege et al

in Advances in Neural Information Processing Systems (2021, December)

Inferring the parameters of a stochastic model based on experimental observations is central to the scientific method. A particularly challenging setting is when the model is strongly indeterminate, i.e ... [more ▼]

Inferring the parameters of a stochastic model based on experimental observations is central to the scientific method. A particularly challenging setting is when the model is strongly indeterminate, i.e., when distinct sets of parameters yield identical observations. This arises in many practical situations, such as when inferring the distance and power of a radio source (is the source close and weak or far and strong?) or when estimating the amplifier gain and underlying brain activity of an electrophysiological experiment. In this work, we present a method for cracking such indeterminacy by exploiting additional information conveyed by an auxiliary set of observations sharing global parameters. Our method extends recent developments in simulation-based inference(SBI) based on normalizing flows to Bayesian hierarchical models. We validate quantitatively our proposal on a motivating example amenable to analytical solutions, and then apply it to invert a well known non-linear model from computational neuroscience. [less ▲]

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See detailIt’s all in their eyes: a three-generation family with branchio-oculo-facial syndrome (BOFS) reveals a heterozygous novel mutation in TFAP2A gene.
VALDES SOCIN, Hernan Gonzalo ULiege; ANDRIS, Cécile ULiege; CROMMEN, Jessica ULiege et al

in Acta Clinica Belgica (2021, December), 2(76), 27-29

Introduction: Ocular defects are important semiological clues for the internist, leading sometimes to diagnose a familial disease. Branchio-oculo-facial syndrome is a rare congenital disorder ... [more ▼]

Introduction: Ocular defects are important semiological clues for the internist, leading sometimes to diagnose a familial disease. Branchio-oculo-facial syndrome is a rare congenital disorder characterized by ophtalmic malformations, branchial skin defects and craniofacial anomalies. Ocular features include coloboma of choroid and/or iris, microphtalmia, cataract, ptosis and strabismus. We herein describe a new three-generation family with BOFS. Patients The proband (A) was the 67 years-old grandfather. He presented with a left eye coloboma and microcornea. His only 39 years-old son (B) was diagnosed as a baby with a left coloboma and microphtalmia, right pre axial polydactilia. As an adult, B had a craniopharyngioma treated with surgery and radiotherapy. The 6 years-old grand daughter (C) had a left coloboma and microphtalmia and a right kidney hydrophrosis. The sister D of the proband presented a branchial fistula and a melanoma and his son (E) had a prolactinoma. Because of this intriguing phenotype, an inherited anomaly closest to BOFS was suspected in this non consanguineous family. Genetic Studies In 2011, BMP4 gene study was unremarkable. In 2018 none PAX2 (coloboma-kidney sundrome) nor PAX6 gene mutation were found, among a panel of different 35 genes. Then, a panel of ocular developmental genetic anomalies was done in this family. Finally, a large MAC-ASD genetic panel found only in A, B and C patients an heterozygous frameshift variant in exon 2/7 of the TFAP2 gene: c.38-56 dup, p.(Ala20ArgfsTer149). This is a likely pathogenic variant (type IV), causing a mutation stop codon in exon 2 in transcription factor AP2-alpha gene (TFAP2A). Discussion TFAP2A mutations have been related with BOFS, ectopic thymus and anophthalmia-microphthalmia syndrome. Reported BOFS associated malformation are diverse and heterogeneous, like in most dominant diseases. We report a novel TFAP2A mutation in a three-generational BOFS affected family. TFAP2A is a retinoic acid response gene to direct ocular morphogenesis. It is localized on the minus strand of chromosome 6. In addition, two antisense non-coding RNA molecules have been identified. TFAP2A also regulates gene expression during embryogenesis of the eye, ear, face, body wall, limbs, kidney and neural tube in humans as well as in Tfap2 knockout mice embryos. A, B and C presented with coloboma whereas B had also right pre axial polydactilia. We thought to also study B and D for a TFAP2A mutation, because there is a down-regulation of AP-2α in some tumors (like hepatic carcinoma), with has an impact on Wnt/β-catenin pathway (like in craniopharyngiomas), and there is abolition of TFAP2A expression in melanoma. Intriguingly, D did not have the familial TFAP2 mutation although she had a melanoma and branchial fistula. Moreover, the presence of two unrelated pituitary tumors in B and E remain unexplained. TFAP2A mosaicism could not been excluded. [less ▲]

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See detailEnergy expenditure measured with indirect calorimetry during the post-ICU hospital stay.
LEPORE, Daniel ULiege; FADEUR, Marjorie ULiege; LUCANIA, Sara ULiege et al

in European Journal of Anaesthesiology (2021, December), 38(e-Suppl 39), 169

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See detailAcylcarnitines profile in survivors of a prolonged ICU stay.
schmitz, Sarah ULiege; BOEMER, François ULiege; FARRAUTO, Laure ULiege et al

in European Journal of Anaesthesiology (2021, December), 38(e-Suppl 39), 169

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See detailPluies, crues, sécheresses : les extrêmes deviennent-ils la norme ?
Degré, Aurore ULiege; Grandry, Maud ULiege

in Bulletin de la Société Royale des Sciences de Liège (2021, November 26), 90

En hydrologie, les valeurs extrêmes revêtent un intérêt capital pour déterminer une probabilité d’occurrence notamment des crues dévastatrices. Les approches statistiques nécessitent une longue chronique ... [more ▼]

En hydrologie, les valeurs extrêmes revêtent un intérêt capital pour déterminer une probabilité d’occurrence notamment des crues dévastatrices. Les approches statistiques nécessitent une longue chronique d’observations indépendantes. Cela constitue un premier enjeu méthodologique. Un second enjeu est celui de la réponse hydrologique des bassins versants. Ainsi, les phénomènes en jeu sont complexes, parfois antagonistes sur l’hydrologie d’un bassin versant et peuvent modifier leur statistique des extrêmes pour différentes variables. Une analyse est proposée au départ des débits de cours d’eau en Wallonie dans le cadre d’un projet Hydrotrend subventionné par le Service public de Wallonie. Les résultats, en accord avec les tendances observées au niveau européen montrent qu’au niveau wallon, ce sont essentiellement les plus grands bassins qui présentent des tendances. Cependant, certaines stations montrent des modifications de la saisonnalité des crues. Sans que ce constat puisse être généralisé, il indique que des modifications du régime hydrologique semblent se présenter suite aux changements climatiques (précipitations), aux changements d’occupation du sol (imperméabilisation) et aux modifications des rivières. Les données disponibles sont encore insuffisantes, cependant, il semble démontré que la notion d’extrême est bel et bien liée à une époque mais les signaux de changements restent encore incertains statistiquement parlant. Les indices illustrés dans cette communication appellent à considérer l’instationnarité hydrologique dans les actions concrètes de gestion et de planification. Les événements hydrologiques de juillet 2021 en Wallonie sont dramatiques. Les comparer aux historiques disponibles pour qualifier leur récurrence est difficile. [less ▲]

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See detailLa planification d'urgence sous tension
Thiry, Aline ULiege; Fallon, Catherine ULiege

in Bulletin de la Société Royale des Sciences de Liège (2021, November 26), 90

The COVID-19 epidemic and the floods in Wallonia in July 2021 are dramatic events but rich in lessons: these two disasters have put to the test the risk management system established over the last few ... [more ▼]

The COVID-19 epidemic and the floods in Wallonia in July 2021 are dramatic events but rich in lessons: these two disasters have put to the test the risk management system established over the last few decades to ensure the protection of society against threats of various kinds: industrial, environmental, terrorist, etc. COVID-19 caught many European countries unaware. Torrential rains almost completely submerged the Vesdre valley. These two disasters required the authors to take a step back and reflect on the profound transformations these disasters provoked in crisis management and emergency planning, in order to open up new lines of research and to launch avenues of reform in this sector, which the authors have been studying for over ten years. [less ▲]

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See detailSerum and bronchoalveolar lavage fluid concentration of osteopontin and fibronectin in West Highland white terriers either affected with canine idiopathic pulmonary fibrosis or healthy and other terriers non predisposed to the disease.
Fastrès, Aline ULiege; Roels, Elodie ULiege; Tutunaru, Alexandru-Cosmin ULiege et al

in Journal of Veterinary Internal Medicine (2021, November 10)

Overexpression of osteopontin (SPP1) and fibronectin (FN1), two molecules associated with pulmonary fibrosis in humans and mice, was recently identified in pro-fibrotic bronchoalveolar lavage fluid (BALF ... [more ▼]

Overexpression of osteopontin (SPP1) and fibronectin (FN1), two molecules associated with pulmonary fibrosis in humans and mice, was recently identified in pro-fibrotic bronchoalveolar lavage fluid (BALF) macrophage populations in West Highland white terriers (WHWTs) affected with canine idiopathic pulmonary fibrosis (CIPF) compared to healthy WHWTs. The aims of the present study were to confirm the overexpression of SPP1 and FN1 genes at the protein level and to assess the potential utility of those proteins as serum and BALF biomarkers of CIPF severity. Serum and BALF concentrations of SPP1 and FN1 were measured using commercially available canine ELISA kits in CIPF WHWTs at diagnosis (n=24), healthy aged-matched WHWTs (n=13) and healthy terriers from other breeds (n=15). Values obtained were compared between groups using Kruskal-Wallis test. Correlations between SPP1 and FN1 concentrations and markers of disease severity (arterial partial pressure in oxygen (PaO2) and 6-minute walked distance (6MWD)) were performed using Spearman test. SPP1 serum concentrations were higher in CIPF WHWTs (median [interquartile range]: 2.15 ng/mL [0.87-5.13]) compared with healthy WHWTs (0.63 ng/mL [0.41-1.63]; P=0.013) and healthy terriers (0.31 ng/mL [0.19-0.51]; P<0.0001), and higher in healthy WHWTs compared with healthy terriers (P=0.002). Higher SPP1 BALF concentrations were found in CIPF (0.34 ng/mL [0.15-0.52]) and healthy WHWTs (0.25 ng/mL [0.14-0.40]) compared with heathy terriers (0.02 ng/mL [0.01-0.08]; P<0.0001 and P=0.002, respectively), while no difference was shown between CIPF and healthy WHWTs (P=0.962). SPP1 serum concentrations negatively correlated with PaO2 (r=-0.502; P=0.007), but not with 6MWD. FN1 serum concentrations were lower in WHWTs either affected with CIPF or healthy (0.81 ng/mL [0.36-1.47] and 0.61 ng/mL [0.24-0.65]) compared with healthy terriers (2.72 ng/mL [2.15-5.21]; P<0.0001 and P=0.001, respectively). No difference was found between groups in BALF FN1 concentrations (P=0.077). No correlation was identified between serum and BALF FN1 concentrations and parameters of CIPF severity. Results of the present study did not confirm the FN1 overexpression found in BALF pro-fibrotic macrophages neither in serum nor in BALF. Serum and BALF FN1 concentrations were not associated with CIPF severity parameters. SPP1 gene overexpression was confirmed at the protein level in serum but not in BALF in CIPF compared with healthy WHWTs. Moreover, SPP1 serum concentration could serve as a biomarker of disease severity as it correlates with PaO2. Finally, the higher serum and BALF SPP1 concentrations found in the WHWT breed compared to other terriers could be linked to their predisposition to CIPF. [less ▲]

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See detailSelf-medication in fitness centers
Dellatte, Julien ULiege; Leclercq, Victoria; Kaux, Jean-François ULiege et al

in British Journal of Sports Medicine (2021, November), 55(S1), 135-136

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See detailWhat are the main risk factors for lower-extremity running-related injuries? A retrospective survey-based on 3669 respondents
SANFILIPPO, Damien ULiege; BEAUDART, Charlotte ULiege; Bruyère, Olivier ULiege et al

in British Journal of Sports Medicine (2021, November), 55(S1), 127

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See detailPREVENTION AND MANAGEMENT OF SPORT-RELATED CONCUSSIONS: CURRENT KNOWLEDGE AND PRACTICES AMONG FIELD STAKEHOLDERS OF THE FRENCH
Martens, Géraldine ULiege; Kaux, Jean-François ULiege; THIBAUT, Aurore ULiege et al

in British Journal of Sports Medicine (2021, November), 55(S1), 68-69

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See detailCURRENT PRACTICE FOR SAFE RETURN-TO-PLAY AFTER LATERAL ANKLE SPRAIN: A SURVEY AMONG FRENCHSPEAKING PHYSICIANS
Aguilaniu, Aude ULiege; Croisier, Jean-Louis ULiege; Schwartz, Cédric ULiege et al

in British Journal of Sports Medicine (2021, November), 55(S1), 42

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See detailCARDIAC FIBROSIS MARKERS: GALECTIN-3 AND SUPPRESSION OF TUMORIGENICITY 2 MEASUREMENT IN PARTICIPANT AT THE TOR DES GÉANTS
Le Goff, Caroline ULiege; Kaux, Jean-François ULiege; SEIDEL, Laurence ULiege et al

in British Journal of Sports Medicine (2021, November), 55(S1), 115

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See detailLe design social, est-ce un champignon ? Le concept d’agencement polyphonique d’Anna Lowenhaupt Tsing pour penser la transition écologique par le design
Hamarat, Yaprak ULiege

in Sciences du Design (2021, November), 14(2), 29-39

Les champignons sont des êtres intimement liés aux autres êtres qui les font apparaître et qui les entourent. En s’appuyant sur ces êtres ni végétaux ni animaux, et particulièrement sur la marchandisation ... [more ▼]

Les champignons sont des êtres intimement liés aux autres êtres qui les font apparaître et qui les entourent. En s’appuyant sur ces êtres ni végétaux ni animaux, et particulièrement sur la marchandisation des matsutakes, les concepts d’agencement polyphonique et de contamination développés par Anna Lowenhaupt Tsing montrent que la force écologique d’un système nait à travers la vulnérabilité des entités qui la composent. L’approche méthodologique et conceptuelle de Tsing résonne particulièrement avec celles du design social et permet de poser un regard original sur le design dans le contexte de la transition écologique. Le design prend soin quand il crée les conditions et les agencements propices à l’établissement d’échanges diversifiés et évolutifs dans le temps entre les humains et les non-humains. L’innovation écologique qu’habite le projet du design social réside dans sa capacité à créer des ensembles riches d’éléments précaires collaboratifs, à l’inverse de la figure de l’autonomie tant mise en valeur dans la vie contemporaine. [less ▲]

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See detailMolecular Analysis of Cryptococcus spp. Reveals Species Diversity and Multilocus Sequence Typing Heterogeneity among People Living with HIV in Kinshasa
Zono, Bive ULiege; SACHELI, Rosalie ULiege; Situakibanza, Hippolyte et al

in Journal of Fungi (2021, October 28), 7(916), 42-43

Objectives: In the Democratic Republic of Congo (DRC), the neuromeningeal cryptococcosis (NMC) hospital prevalence varies between 8.8 and 11% with a death rate of about 50%. However, the Cryptococcus ... [more ▼]

Objectives: In the Democratic Republic of Congo (DRC), the neuromeningeal cryptococcosis (NMC) hospital prevalence varies between 8.8 and 11% with a death rate of about 50%. However, the Cryptococcus isolates circulating are poorly and formerly described. We describe the molecular characterization of Cryptococcus spp. isolated from people living with HIV (PLWHIV), and the association between NMC severity factors and the Cryptococcus multilocus sequence typing (MLST) profiles. Materials & Methods: Cerebral spinal fluid (CSF) was collected from PLWHIV with neuromeningeal syndrome hospitalized in three Kinshasa public hospitals from 1 February 2019 to 29 February 2020, and cultured on Sabouraud dextrose agar + chloramphenicol medium afterwards. Serotyping PCR, internal transcribed spacer (ITS) sequencing, and MLST from next-generation sequencing (NGS) data were performed to genotype the Cryptococcus isolates. Raw NGS data were processed and the loci alleles were manually extracted using Geneious software. NMC severity factors such as hypoglycorrhachia (<50 mg/dL), raised CSF opening pressure (>30 cm water), and the patient pejorative outcome were compared to the Cryptococcus sequence type (ST)-MLST profile which was identified, using Pearson chi-square test or Fisher exact test. Results: Out of 29 isolates included in the present study, 23 (79.3%; 95% IC: 65.5–93.1) have been identified as serotype A using serotyping PCR, while 6 (20.7%; 95% IC: 6.9–34.5) had unidentifiable profile. Moreover, all the 29 isolates have been characterized by ITS sequencing as follow: Cryptococcus neoformans var. grubii (23 of 29 isolates, 79.3%), Cryptococcus curvatus (5 of 29, 17.2%), and Cryptococcus laurentii (1 of 29, 3.5%). Apart from this highlighted species diversity, C. neoformans var. grubii isolates were all identified as molecular type VNI using the MLST ISHAM scheme, with seven different STs including ST93 (14 out of 23, 60.9%), ST53 (1 out of 23, 4.3%), ST31 (1 out of 23, 4.3%), ST5 (1 out of 23, 4.3%), ST4 (1 out of 23, 4.3%), ST69 (1 out 23, 4.3%), and one novel ST not yet reported worldwide (2 out of 23, 8.6%). Furthermore, two isolates (8.6%) showed a mixed molecular profile (under investigation). Phylogenetic analysis carried out by the unweighted pair group method with arithmetic mean algorithm (UPGMA) of concatenated gene sequences from the seven MLST loci indicated that the main ST isolated in this study is very close to the only isolate previously reported from the DRC. The others are distant from it, even more so for ST69. All the STs identified in the present study have been isolated in the neighbouring countries of the DRC except for ST53, which has only been reported in Southeast Asia. Among NMC severity factors, only the patient pejorative outcome was associated with the minority STs infections (87.5%, p = 0.02) (ST53, ST31, ST5, ST4, STA, ST69). Conclusions: Molecular analysis of Cryptococcus spp. isolates showed wide species diversity, and ST-MLST heterogenicity within the only one molecular type identified. The existence of the STs isolated in this study in the DRC neighbouring countries suggests probable close-to-home spread. Furthermore, infections due to minority STs were associated with a pejorative outcome than those due to ST93. [less ▲]

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See detailL’exploration des villes: les médiatisations visuelles entre mouvement et temporalité
Dondero, Maria Giulia ULiege; D'Armenio, Enzo ULiege

in Espressione e Contenuto: Rivista dell'Associazione Italiana di Studi Semiotici (2021, October 12), XV(31), 235-246

Our paper aims to address the modalities of exploration, data collection and analysis of urban space accomplished through different visual and interactive media. It consists of two parts. In the first ... [more ▼]

Our paper aims to address the modalities of exploration, data collection and analysis of urban space accomplished through different visual and interactive media. It consists of two parts. In the first part we investigate how artists and scientists have collected visual (and other) data that have been used as documents to study the city. We compare the strategies of data collection and the enunciative strategies of the resulting visualisations. In the second part, we propose a typology of virtual explorations of the city based on media practices implemented via various computer platforms. Virtual reality videos, on the other hand, allow for continuous exploration, organised by a prior staging, which leaves the angle of vision free in immersion. Finally, digital reproductions of cities -including those of video games and Digital Heritage projects - will complete our typology. Video games impose an active exploration of urban spaces, transforming it in accordance with a thematic scripting of movement. [less ▲]

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See detailPhysical properties of Hi'iaka from stellar occultation data
Fernández-Valenzuela, Estela; Ortiz Moreno, Jose Luis; Holler, Bryan et al

in Bulletin of the American Astronomical Society (2021, October 01), 53(7), 50305

Two very bright stellar occultations by Hi'iaka, the largest satellite of the dwarf planet Haumea, were predicted to take place during in April 2021. Since the uncertainty on Hi'iaka's shadow path was ... [more ▼]

Two very bright stellar occultations by Hi'iaka, the largest satellite of the dwarf planet Haumea, were predicted to take place during in April 2021. Since the uncertainty on Hi'iaka's shadow path was large due to uncertainty on Hi'iaka's position with respect to Haumea, we performed an observational campaign using medium-sized telescopes to obtain high accuracy astrometric data of Hi'iaka's orbit around Haumea. The astrometric data allowed us to successfully observe the first stellar occultation on April 6[SUP]th[/SUP], with final path crossing North Africa. We only obtained one positive chord in this event from the TRAPPIST-North telescope at Oukaïmeden Observatory (Morocco), but thanks to this detection, we were able to obtain a more accurate path for the second event on April 16[SUP]th[/SUP]. The second shadow path was predicted to cross the continental US from East to West. We carried out a huge observational campaign involving more than 50 professional and amateur observatories across the US and southern Canada. The final path of this second stellar occultation moved slightly to the North of the predicted path and, as a result, we were able to obtain 5 positive chords and negative chords only from the south of the shadow. We also collected photometric data in order to obtain Hi'iaka's rotational light-curve and calculate its three-dimensional shape. The rotational light-curve was obtained by observing the unresolved system of Haumea-Hi'iaka and removing Haumea's rotational light-curve from the data. Using Hi'iaka's rotational light-curve we obtained the rotational phase at which each stellar occultation took place, which allowed us to obtain a three-dimensional model of the satellite. Preliminary results from the stellar occultation show that Hi'iaka, with a triaxial shape as suggested in previous publications, is larger than what has been thought before and with a similar albedo to that of Haumea. In this talk we will present our analysis and preliminary results of some of Hi'iaka's physical properties. [less ▲]

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See detailPhysical properties of the cubewano 19521 Chaos from a multi-chord stellar occultation
Vara-Lubiano, Mónica; Morales, Nicolás; Rommel, Flavia et al

in Bulletin of the American Astronomical Society (2021, October 01), 53(7), 30711

Trans-Neptunian Objects (TNOs) have had an increasing interest since the discovery of (15760) Albion in 1992. These objects are considered remnants of the Solar System formation, and can thus provide ... [more ▼]

Trans-Neptunian Objects (TNOs) have had an increasing interest since the discovery of (15760) Albion in 1992. These objects are considered remnants of the Solar System formation, and can thus provide clues about its origin and evolution. One of the best techniques to study TNOs from ground-based telescopes are stellar occultations which, if combined with photometric data, permit to obtain physical properties of the TNO such as its size, shape, and albedo. With this in mind, we predicted, observed, and analyzed the stellar occultation of the Gaia source 3444789965847631104 caused by the cubewano (19521) Chaos on the 20th of November 2020. The prediction was part of the searching program carried out by the Lucky Star project collaboration. We observed the object with the 1.23-m telescope at Calar Alto Observatory (Almería, Spain) two days before the event to update the prediction. The occultation observing campaign involved 19 observing stations, both professional and amateur, and resulted in three positive detections and 11 negative detections. Five teams could not observe due to bad weather. We fitted the positive chords' extremities to an ellipse to derive Chaos' projected size and shape and determine its geometric albedo. The preliminary area-equivalent diameter obtained is slightly smaller than the one derived with Herschel thermal data. However, we are still analyzing photometric data to complement and improve these results. [less ▲]

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See detailThe discovery of Fe and Ni free atoms in comets atmospheres even far from the Sun
Jehin, Emmanuel ULiege; Manfroid, Jean ULiege; Hutsemekers, Damien ULiege

in Bulletin of the American Astronomical Society (2021, October 01), 53(7), 10506

In this talk I will present the unexpected discovery of iron and nickel free atoms in the coma of comets, even far from the Sun. We have identified dozens of FeI and NiI lines in the high resolution ... [more ▼]

In this talk I will present the unexpected discovery of iron and nickel free atoms in the coma of comets, even far from the Sun. We have identified dozens of FeI and NiI lines in the high resolution optical spectra of most of the comets observed by our team in the last 20 years using UVES at the VLT [1]. These lines are ubiquitous in cometary comae, we found them also in the interstellar comet 2I/Borisov [2,3] and they were recently identified in archival spectra of the Great comet Hyakutake [3,4]. If various metallic lines were already detected in the sungrazer comet C/1965 Ikeya-Seki [5], that approached the Sun so close that dust grains vaporized, it was a surprise to find them in comets as far as 3.25 au, where the equilibrium temperature is far too low to allow sublimation of silicates (Tsub ≥ 1200K) and sulfides (Tsub ≥ 600K). The spatial extension of the lines is very short indicating that the FeI and NiI atoms originate from the inner coma, close to the nucleus. We developed a fluorescence model that allowed to compute their production rates. The NiI/FeI abundance ratios cluster around NiI/FeI~1 and does not depend on the heliocentric distance or the comet dynamical type [1], but there is a correlation with the level of carbon-chain depletion (C[SUB]2[/SUB]/CN) [3]. This Ni/Fe ratio is about 10x higher than what is measured in the Sun and the meteorites, as well as in the coma of Ikeya-Seki and the dust of 1P/Halley [6] indicating an other orgins. We made the hypothesis that these atoms could be released from organometallic complexes, yet undetected in the cometary material, such as carbonyls that have much lower sublimation temperatures. In particular Fe(CO)[SUB]5[/SUB] and Ni(CO)[SUB]4[/SUB] are expected to sublimate at Tsub~ 100K, intermediate between the sublimation temperature of H[SUB]2[/SUB]O and CO[SUB]2[/SUB]. The higher sublimation rate of Ni(CO)[SUB]4[/SUB] with respect to Fe(CO)[SUB]5[/SUB] would naturally explain the overabundance of nickel. In the present contribution, we summarize this discovery and the challenges it raises. References: [1] Manfroid, J., Hutsemékers, D., Jehin, E.: Nature 593, 372 (2021) [2] Opitom, C., Jehin, E., Hutsemékers, D., et al.: A&A, accepted (2021) [3] Hutsemékers, D., Manfroid, J., Jehin, E. et al.: A&A, accepted (2021) [4] Bromley, S., Ne, B., Loch, S., et al. 2021, arXiv e-prints, arXiv:2106.04701 [5] Preston, G.W.: ApJ 147, 718 (1967). Illustration: Detection of heavy metals in the atmosphere of comet C/2016 R2. Credit: ESO/L. Calçada, SPECULOOS Team/E. Jehin, Manfroid et al. [less ▲]

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See detailCharacterizing the aftermath of a medium-sized outburst of Centaur 29P/Schwassmann-Wachmann 1 using HST/WFC3
Allen, Johannes; Venkataramani, Kumar; Yang Li, Jian et al

in Bulletin of the American Astronomical Society (2021, October 01), 53(7), 30704

Comet 29P/Schwassmann-Wachmann 1 (hereafter, 29P) is a highly active andprominent member of the Centaur population. Centaurs are icy bodies with orbits between Jupiter and Neptune, which dynamically link ... [more ▼]

Comet 29P/Schwassmann-Wachmann 1 (hereafter, 29P) is a highly active andprominent member of the Centaur population. Centaurs are icy bodies with orbits between Jupiter and Neptune, which dynamically link the Jupiter-family comets to the trans-Neptunian objects of the outer solar system. Hovering at large heliocentricdistances, where the sublimation of water ice is negligible, the mechanism driving the outbursts of comet 29P remains undetermined. We present target of opportunity observations collected with the Hubble Space Telescope (HST) Wide Field Camera 3 (WFC3), acquired following reports of a possible fragmentation event of 29P before Oct. 1.3, 2019 (M.S.P. Kelley, et al., ATEL 13164, 2019). Our observing cadence captured 29P within two days of a 0.9 mag, thus medium-sized outburst, and provided observations before and after the event for context and to probe the development of the ejecta. Between the purported fragmentation event and the HST observations, 29P underwent two small outbursts on Oct. 7 and Oct. 16, 2019 (both of amplitude 0.4-0.5 mag; Q. Z. Ye et al., ATEL 13179, 2019; M. S. P. Kelley, UMD, priv. comm.), followed by a medium-sized outburst with an amplitude of 0.9 mag around Oct. 19.5, 2019 (D. Bodewits, AU; R. Miles, BAA comet section, priv. comm). HST observed 29P three times, on Oct. 14.75, Oct. 20, and Oct. 28.5, 2019. A detailed characterization of the coma morphology, dynamics, and the results of deep, sub-km search for fragments will be provided in our presentation. <P />Cross-listed as presentation #503.02. [less ▲]

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See detailA surprising similarity to solar system comets from high resolution optical spectroscopy of 2I/Borisov
Opitom, Cyrielle; Jehin, Emmanuel ULiege; Hutsemekers, Damien ULiege et al

in Bulletin of the American Astronomical Society (2021, October 01), 53(7), 50502

2I/Borisov, discovered on August 20, 2019, is the first visibly active interstellar comet observed in the solar system. We observed 2I with UVES, the high-resolution optical spectrograph mounted on the ... [more ▼]

2I/Borisov, discovered on August 20, 2019, is the first visibly active interstellar comet observed in the solar system. We observed 2I with UVES, the high-resolution optical spectrograph mounted on the UT2 telescope at Paranal observatory in Chile, between November 15, 2019, and March 16, 2020. Our 12 epochs covered a heliocentric distance range from 2.1 au pre-perihelion to 2.6 au post-perihelion. We will present the results of this observing campaign. We performed several key measurements, some being made for the first time in the coma of an interstellar comet. We detected emissions from the radicals OH, NH, CN, CH, C[SUB]2[/SUB], and NH[SUB]2[/SUB], the [OI] forbidden oxygen lines at 557.73, 630.03, and 636.37 nm, and more surprisingly several FeI and NiI lines. We derived the abundance of iron and nickel, log[Q(NiI)]=21.88±0.07 molecules/s and log[Q(FeI)]=21.67±0.16. This corresponds to a ratio of log(NiI/FeI)=0.21±0.18, in agreement with the value measured for solar system comets. We used the (0,8,0) and (0,9,0) ro-vibronic bands to derive an NH[SUB]2[/SUB] ortho-to-para ratio of 3.21±0.15, also consistent with measurements in solar system comets. We measured the ratio between the green [OI] line and the red doublet and find a value of G/R=0.31±0.05 close to perihelion, with a tentative increasing trend with the heliocentric distance. This high value of the G/R is consistent with the high CO abundance already reported in the coma of 2I and the increase of the CO/H[SUB]2[/SUB]O ratio as the comet moved away from the Sun. Finally, we used the OH (0-0) band around 309 nm to derive a water production rate of (2.2±0.2)x10[SUP]26[/SUP] molecules/s on December 24 and 26, 2019. In conclusion, high spectral resolution observations of the interstellar comet 2I/Borisov at the VLT, and the NH[SUB]2[/SUB] ortho-to-para ratio and Ni/Fe ratios we measured reveal a remarkable similarity to solar system comets. The G/R ratio is unusually high but this is consistent with a high CO abundance, and potentially suggests a formation in a colder environment. [less ▲]

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See detailPhysical characterization of the active asteroid (6478) Gault from a multi-apparition campaign (2018-2020)
Devogele, Maxime; Ferrais, Marin ULiege; Jehin, Emmanuel ULiege et al

in Bulletin of the American Astronomical Society (2021, October 01), 53(7), 30904

(6478) Gault is a main-belt asteroid that was found to display cometary activity in late 2018-early 2019 [1]. During its 2018-2019 apparition, Gault experienced several activity events leading to the ... [more ▼]

(6478) Gault is a main-belt asteroid that was found to display cometary activity in late 2018-early 2019 [1]. During its 2018-2019 apparition, Gault experienced several activity events leading to the development of up to three distinct tails [2,3,4]. Many hypotheses such as impacts with smaller objects, YORP induced spin-up [5], sublimation of volatiles [6], or even the presence of a satellite in a highly eccentric and chaotic orbit, were considered to explain these events. <P />In this talk we present new photometric and spectroscopic observations of Gault obtained during the 2018-2019 and 2020 apparitions. These observations were obtained both when Gault was active (during the 2018-2019 apparition) and when it was found to be inactive during the 2020 apparition. For the first time we determine an accurate rotation period with high confidence of P=2.4929 ± 0.0003 h with a low amplitude of only 0.06 mag. This rotation period associated with a low lightcurve amplitude is consistent with a bulk density no smaller than 1.85 g cm3 in order for its activity to be triggered by the YORP spin-up mechanism. Our spectral analysis is consistent with Gault being of ordinary chondrite-like composition. Several spectra and a large datasets of broad band spectro-photometric observations obtained over the two oppositions do not show any sign of spectral variation over time. <P />Finally, we did not find any statistically significant signal of non-gravitational accelerations due to its activity even after the addition of previously unidentified detections of Gault dating back to 1958, which increased its orbital arc by a factor of almost 2. <P />These results were published in [7]. <P />References: <P />[1]: Smith K. W., Denneau L., Vincent J. B., et al., 2019, CBET, 4594 <P />[2]: Jehin E., Ferrais M., Moulane Y., et al. 2019, CBET, 4606 <P />[3]: Ye Q., et al., 2019, The ApJ Letters, 874, L16 <P />[4]: Jewitt D., Kim Y., Luu J., et al. 2019, The ApJ Letters, 876, L19 <P />[5]: Kleyna J. T., et al., 2019, The ApJ Letters, 874, L20 <P />[6]: Ferrín I., Fornari C., Acosta A., 2019, MNRAS, 490, 219 <P />[7]: Devogèle M., Ferrais M, Jehin E, et al. 2021, MNRAS, 505, 245 [less ▲]

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See detailRotation period determination of NASA Lucy mission target (52246) Donaldjohanson
Ferrais, Marin ULiege; Jehin, Emmanuel ULiege; Manfroid, Jean ULiege et al

in Bulletin of the American Astronomical Society (2021, October 01), 53(7), 30619

(52246) Donaldjohanson is a small 4 km in diameter main-belt asteroid, and a C-type belonging to the Erigone collisional family [1]. The Lucy Mission is a NASA Discovery class mission that will launch a ... [more ▼]

(52246) Donaldjohanson is a small 4 km in diameter main-belt asteroid, and a C-type belonging to the Erigone collisional family [1]. The Lucy Mission is a NASA Discovery class mission that will launch a spacecraft in October 2021 to explore several Jupiter Trojan asteroids. On its way to Jupiter's orbit, Lucy will first encounter Donaldjohanson in 2025. However, few physical characteristics are known about this body at present time. <P />Here, we present new photometric observations of Donaldjohanson acquired from November 2020 to February 2021 with the two 60-cm TRAPPIST telescopes [3]. During this apparition, we obtained 91 individual series that revealed a very slow rotator featuring a large amplitude of the rotational lightcurve. We determined a rotation period of ~252 h and an amplitude of ~1 magnitude. <P />References: <P />[1] Nesvorný, D., Broz, M., Carruba, V., et al., 2015, In: Asteroids IV, pp. 297-321 <P />[2] Marchi, S., Levison, H., Olkin, C., et al., 2020, EPSC, 163 <P />[3] Jehin, E., Gillon, M., Queloz, D., et al., 2011, The Messenger, 145, 2 [less ▲]

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See detailHypercalcémie aggravée par l’administration de vitamine D chez un patient adulte révélant une mutation hétérozygote composite CYP24A1 : réponse et traitement à long terme par rifampicine.
Parotte, Marie Christine; VALDES SOCIN, Hernan Gonzalo ULiege; CAVALIER, Etienne ULiege

in Annales d'Endocrinologie (2021, October 01), 82

Cas clinique : un patient de 61 ans est hospitalisé avec une perte de poids (10kg) et une insuffisance rénale aigue. Il prenait de la vitamine D 800 UI/j depuis quelques mois. A l’admission : Calcium : 4 ... [more ▼]

Cas clinique : un patient de 61 ans est hospitalisé avec une perte de poids (10kg) et une insuffisance rénale aigue. Il prenait de la vitamine D 800 UI/j depuis quelques mois. A l’admission : Calcium : 4.2 mmol/L (2.1-2.5), PTH : 5ng/ml, PTH-Rp <20 pg/ml, 25-hydroxy-vitD3(cholécalciférol) : 76 ng/ml (<60), PO4 : 1.1 mmol/L (0.8-1.45), ACE <25, normo calciurie, pas de lithiases rénales. On note une ostéoporose lombaire et une ostéopénie fémorale sévère. Le PET scan corps entier exclu une lésion néoplasique. Une fibrose pulmonaire interstitielle idiopathique est décelée. Des prélèvements ganglionnaires excluent une sarcoïdose. L’hydratation, la calcitonine, les corticoïdes et l’acide zoledronique ne normalisent pas la calcémie. La 1,25-dihydroxy-vitD3(calcitriol) : 161 ng/ml (29-82) et le FGF23 : 284 pg/ml (23-95) font suspecter un déficit fonctionnel de la CYP24A1, enzyme responsable de la dégradation du cholécalciférol et du calcitriol. Une analyse génétique par NSG confirme une mutation hétérozygote de CYP24A1 combinant : c.62del (p.Pro21ArFs 8) et c.428_430 del (p.Glu143del), mutations décrites de classe V. Depuis 1 an, l’administration de rifampicine 300 mgx2/J permet de normaliser le bilan phosphocalcique : calcium 2.6 mmol/L, PTH 15 ng/ml, 1-25 vitD 46 pg/ml. Conclusions : Les mutations inactivantes de CYP24A1 sont une cause rare d’hypercalcémie : elles contre indiquent la supplémentation en vitamine D et l’exposition solaire. La rifampicine, inducteur enzymatique stimulant la CYP3A4 et favorisant le catabolisme des métabolites de vitamine D, est un traitement efficace et bien toléré pour cette affection (Hawkes & al. J ClinEndocMetab 2017). [less ▲]

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See detailRefurbishment concepts for a student housing at the Otto Wagner Areal in Vienna under the aspects of sustainability, energy efficiency and heritage protection
El Nagar, Essam ULiege; Munde, Simran; Lemort, Vincent ULiege

in IOP Conference Series: Earth and Environmental Science (2021, October), 863(1), 012047

For the Otto Wagner area which is situated in the west of Vienna, one pavilion is selected to be refurbished for sustainable and energy-efficient construction to simulate the thermal and energy ... [more ▼]

For the Otto Wagner area which is situated in the west of Vienna, one pavilion is selected to be refurbished for sustainable and energy-efficient construction to simulate the thermal and energy performance of the building. The selected pavilion has been redesigned to be used as a student residence while preserving the cultural heritage. A dynamic building simulation model is used to improve the energy efficiency and livelihood of Otto Wagner area with the main focus on heritage conservation. The pavilion of four levels is re-designed according to the proposed regulations of plus energy university building to become a student residence. The energy demand can be decreased while preserving the buildings’ heritage requirements. Various changes are made through Sefaira tool in SketchUp model: optimization of the U-values of roof, walls and floor, addition of different layers of sustainable energy efficient insulation materials to decrease the overall energy demand, vacuum insulated panels and rigid cellulose board used to maintain existing roofline and calcium silicate boards to allow for vapor permeability in the brick walls, all working towards achieving the standards of zero energy buildings in Austria. The specific energy demands for heating, cooling and lighting are decreased in the proposed model to reduce the overall energy demand. The main goal of this study is achieving a plus energy district for the entire Otto Wagner area by improving the building envelope and integrating renewable energies using Polysun simulation tool. The selected building achieved the standards of zero energy buildings in Austria by optimizing the energy performance and to assess the thermal comfort in the building, both natural ventilation and mechanical ventilation are used to reduce the summer loads. [less ▲]

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See detailEconomic benefit of high strength steel sections for steel structures
Saufnay, Loris ULiege; Jaspart, Jean-Pierre ULiege; Demonceau, Jean-François ULiege

in ce/papers (2021, September 01), 4(2-4), 1543-1550

The present work aims at studying the field of interest of high strength steel rolled sections (fy>460 MPa) for steel structures from an economic point of view. Whilst these high strength steel profiles ... [more ▼]

The present work aims at studying the field of interest of high strength steel rolled sections (fy>460 MPa) for steel structures from an economic point of view. Whilst these high strength steel profiles do not exist yet, steelmakers are able to produce more resistant steels through more efficient production processes and a future emerging of these particular steel profiles is likely to occur. The use of this kind of steels can lead to a significant material saving. So, the use of high strength steel leads to lighter structures requiring smaller foundations, lower transportation and construction costs but also emitting less CO_2. However, buckling, fatigue or deflection requirements often reduce the advantage of high strength steels. It is for this reason that the designer is sometimes reluctant to use them. A study establishing the areas of economic benefit of high strength steel tubes in steel and composite structures had already been carried out at the University of Liège. The goal of the present is to extend this study to rolled sections (H-shape and I-shape). It therefore consists in providing methods in order to help the designer determining the economic benefit of high strength steel for structural elements subjected to different loadings. These ones are then used to determinate the areas of economic benefit of the high strength steels in comparison to regular steel, depending on their relative costs. [less ▲]

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See detailAnalytical model for the prediction of the plastic shear resistance of the panel zone in welded joints
Corman, Adrien ULiege; Demonceau, Jean-François ULiege; Jaspart, Jean-Pierre ULiege

in ce/papers (2021, September 01), 4(2-4), 995-1005

This article addresses the problem of prediction of the plastic shear resistance of the panel zone (PZ) in welded steel beam-to-column joints under monotonic loading. Existing analytical models are first ... [more ▼]

This article addresses the problem of prediction of the plastic shear resistance of the panel zone (PZ) in welded steel beam-to-column joints under monotonic loading. Existing analytical models are first critically reviewed through comparisons with available experimental data. These comparisons reveal that none of them is able to accurately capture all the complex phenomena governing the plastic shear resistance of the PZ. Therefore, a new analytical model is developed based on the extensive use of finite element (FE) analysis. This approach includes the development and validation of a FE model within the Abaqus environment and the use of the so-validated model in order to perform a parametric study on (non-)axially loaded (un-)stiffened interior and exterior joint configurations. This parametric study helps to gain a better understanding of the actual distributions of stresses within the PZ. Based on these observations, a new analytical model is proposed and validated against the numerical results. This model proves to work well and to outperform existing analytical models by providing a more coherent estimation of the plastic shear resistance of the PZ. [less ▲]

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See detailEfnb2 haploinsufficiency induces early gap junction plaque disassembly and endocytosis in the cochlea
Defourny, Jean ULiege

in Brain Research Bulletin (2021, September 01)

Chromosome 13q deletions encompassing EFNB2, which encodes the transmembrane protein ephrin-B2, are likely to cause syndromic forms of sensorineural hearing loss of unclear origin. Thus, unravelling the ... [more ▼]

Chromosome 13q deletions encompassing EFNB2, which encodes the transmembrane protein ephrin-B2, are likely to cause syndromic forms of sensorineural hearing loss of unclear origin. Thus, unravelling the pathogenic mechanisms could help to improve therapeutic strategies. In the cochlea, adjacent non-sensory epithelial cells are connected via gap junction channels, the activity of which is critical to maintain cochlear homeostasis. Here we show that ephrin-B2 promotes the assembly of connexin 30 (Cx30) gap junction plaques (GJPs) between adjacent non-sensory Deiters' cells. An in situ proximity ligation assay revealed that ephrin-B2 preferentially interacts with Cx30 in the periphery of the GJPs, i.e. where newly synthesized connexin hemichannels accrue to the GJP. Moreover, we observed that heterozygous mice encoding an Efnb2 null allele display excessive clathrin-mediated internalization of Cx30 GJPs in early postnatal stages. Finally, an in vitro organotypic assay revealed that ectopic activation of ephrin-B2 reverse signalling promotes the internalization of Cx30 GJPs. These data argue in favor of a cell-autonomous, Eph receptor-independent role of ephrin-B2 in the assembly of Cx30 GJPs. According to recent observations, early GJP degradation could certainly play a role in the pathogenic process leading to progressive sensorineural hearing loss due to Efnb2/EFNB2 haploinsufficiency. [less ▲]

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See detailWhat are the main risk factors for lower-extremity running-related injuries? A retrospective survey-based on 3669 respondents
SANFILIPPO, Damien ULiege; BEAUDART, Charlotte ULiege; Gaillard, Allan et al

in Medicina dello Sport: Rivista di Fisiopatologia dello Sport (2021, September), 74(Suppl. 1 to n.3), 29

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See detailREPRODUCIBILITY OF A VISUAL PERFORMANCE ASSESSMENT AND INFLUENCE OF SPECIFIC VISUAL TRAINING
Renson, Aubry; Andris, Cécile ULiege; Heine, Stephane ULiege et al

in Medicina dello Sport: Rivista di Fisiopatologia dello Sport (2021, September), 74(Suppl. 1 to n.3), 110-111

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See detailThe Effects Of Transcranial Direct Current Stimulation (tDCS) On Endurance Parameters In Confirmed Athletes
Bornheim, Stephen ULiege; Bayard, Maxime; Deneve, Marie et al

in Medicina dello Sport: Rivista di Fisiopatologia dello Sport (2021, September), 74(Suppl. 1 to n.3), 111

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See detailWhere do we stand with sport-related concussion (SRC) prevention and management? An international survey among field stakeholders
Martens, Géraldine ULiege; Kaux, Jean-François ULiege; Thibaut, Aurore ULiege et al

in Medicina dello Sport: Rivista di Fisiopatologia dello Sport (2021, September), 74(Suppl. 1 to n.3), 61

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See detailThe potential of electrical imaging for field root zone phenotyping
Garré, Sarah ULiege; Deswaef, T.; Borra-Serrano, I. et al

in Earthdoc (2021, August 31), 2021(1), 1-5

Providing enough food for a growing population while preserving natural resources and biodiversity is one of the challenges of the 21st century. A key pathway to maximize yields in a sustainable way is to ... [more ▼]

Providing enough food for a growing population while preserving natural resources and biodiversity is one of the challenges of the 21st century. A key pathway to maximize yields in a sustainable way is to select and grow crops that are optimally adapted to their environment. Plant performance is determined by characteristics or ‘traits’ which are partially genetically determined. Nevertheless, cultivars with the same genome (G) express different appearances or ‘phenomes’ in different environments (E) and under different management practices (M). Phenotyping the below-ground traits of plants is not straightforward, due to the opaque nature of soil. Non-invasive geophysical techniques to study the root zone have substantially advanced in recent years.Their biggest potential lies in indirect monitoring of water depletion in the root zone, especially in time-lapse mode. To explore the potential of integrating geophysics in a field phenotyping platform, we first generated a range scenarios of soil moisture dynamics for different soils and grass cultivars. Then we generated ERT data from these distributions for selected electrode setups and then inverted them back to obtain conductivity distributions. In this way, we checked the performance of different electrode arrays to delineate root water uptake patterns in various realistic conditions. [less ▲]

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See detailCOVID-19 in liver transplant candidates: wait-list outcomes and post-transplant course
Perricone, G; Duvoux, C; Mazzarelli, C et al

in Transplant International (2021, August), 34(S1 OP232), 41

Background: The impact of prior SARS-CoV-2 infection on patients on the waiting list for liver transplantation (LT) and on their post-LT course is presently unknown. Methods: Data from adult LT candidates ... [more ▼]

Background: The impact of prior SARS-CoV-2 infection on patients on the waiting list for liver transplantation (LT) and on their post-LT course is presently unknown. Methods: Data from adult LT candidates with laboratory confirmed SARSCoV- 2 infection was collected across Europe and all consecutive patients with symptomatic COVID-19 were included in the analysis. Results: From February 21st to November 20th, 2020, 136 adult cases with laboratory-confirmed SARS-CoV-2 infection from 33 centers in 10 European countries were collected, with 113 having symptomatic COVID-19. Thirtythree (29.2%) were managed as outpatients, 80 (70.8%) required hospitalization including admission to the intensive care unit (28/80, 35%). Thirtyseven (37/113, 32.7%) patients died after a median of 18 (10-30) days, respiratory failure being the major cause (33/37, 89.2%). The 60-day mortality risk did not change between first (35.3%, 95% CI 23.9-50.0) and second wave (26.0%, 95% CI 16.2-40.2). Multivariable Cox regression analysis showed MELD score !15 (MELD15-19:HR 6.09 95%CI 2.01-18.44; MELD ! 20:HR 5.21, 95%CI 1.76-15.45) and dyspnea on presentation (HR:4.1, 95%CI 2.09-8.06) being the two negative independent factors for mortality. Twenty-six patient received a LT after a median time of 78.5 (IQR:44-102) days and 25 are alive after a median follow-up of 118 days (IQR:31-170). Conclusions: Mortality of LT candidates with symptomatic COVID-19 was high (32.7%) peaking at 45% in decompensated cirrhotic with MELD > 15 and did not significantly differ between the 2 waves of the pandemic, respiratory failure being the major cause of death thus supporting high priority for vaccination. Prior SARS-CoV-2 infection did not affect early post-transplant survival (96%). ª [less ▲]

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See detailBamQuery: A new proteogenomic tool to explore the immunopeptidome and validate tumor‐specific antigens
Ruiz, Maria Virginia; Apavaloaei, Anca; Zhao, Qingchuan et al

in European Journal of Immunology (2021, August), 51(S1), 60

MHC class I–associated peptides (MAPs), collectively referred to as the immunopeptidome, have a pivotal role in cancer immunosurveillance. While MAPs were long thought to be solely generated by the ... [more ▼]

MHC class I–associated peptides (MAPs), collectively referred to as the immunopeptidome, have a pivotal role in cancer immunosurveillance. While MAPs were long thought to be solely generated by the degradation of canonical proteins, recent advances in the field of proteogenomics (genomically-informed proteomics) evidenced that ∼10% of MAPs originate from allegedly noncoding genomic sequences. Among these sequences, the endogenous retroelements (EREs) are under intense scrutiny as a possible source of cancer-specific antigens (TSAs). With the increasing number of cancer-oriented immunopeptidomic and proteogenomic studies comes the need to accurately attribute an RNA expression level to each MAP identified by mass-spectrometry. Here, we introduce BamQuery (BQ), a computational tool to count all reads able to code for any MAP in any RNA-seq data chosen by the user, and to annotate each MAP with all available biological features. Using BQ, we found that most canonical MAPs can derive from an average of two different genomic regions, whereas most tested ERE-derived MAPs can be generated by numerous (median of 210) different genomic regions and RNA transcripts. We show that published ERE MAPs considered as TSA candidates can be coded by numerous other genomic regions than those previously studied, resulting in high undetected expression in normal tissues. We also show that some mutated neoantigens previously published as presumably specific anti-cancer targets can in fact be generated by other non-mutated, non-coding, widely expressed RNA-seq reads in normal tissues. We therefore conclude that BQ could become an essential tool in any TSA-identification/validation pipelines in the near future. [less ▲]

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See detailMesenchymal stromal cells combined with everolimus promote Treg expansion but do not synergize in a rat liver transplant rejection model
VANDERMEULEN, Morgan ULiege; ERPICUM, Pauline ULiege; BLETARD, Noëlla ULiege et al

in Transplant International (2021, August), 34(S1 OP519), 101

Background: Mesenchymal stromal cells (MSCs) have particular properties that can be of interest in organ transplantation, including expansion of regulatory T cells (Tregs), a key factor in graft tolerance ... [more ▼]

Background: Mesenchymal stromal cells (MSCs) have particular properties that can be of interest in organ transplantation, including expansion of regulatory T cells (Tregs), a key factor in graft tolerance induction. The immunosuppression to be associated with MSCs has not yet been defined. Additionally, the impact of the association of everolimus with MSCs on Treg expansion and on induction of liver graft tolerance has never been studied. The aim of this study was to evaluate the effects of MSCs combined, or not, with everolimus, on Treg expansion and in a model of liver transplantation (LT) rejection in the rat. Methods: Firstly, Lewis rats received intravenous MSCs at D9 with/without subcutaneous everolimus from D0 to D14. Analysis of circulating Tregs was performed at D0, D14 and D28. Secondly, 48 h after LT with a Dark Agouti rat liver, 30 Lewis rats were randomized in 3 groups: everolimus (subcutaneous for 14 days), MSCs (intravenous injection at D2 and D9), or both everolimus and MSCs. Rejection of the liver graft was assessed by liver tests, histology and survival. Results: Individually, MSC infusion and everolimus promoted Treg expansion in rats, and everolimus had no negative impact on Treg expansion when combined with MSCs. However, in the LT model, injections of MSCs 2 and 9 days following LT were not effective at preventing acute rejection, and the combination of MSCs with everolimus failed to show any synergistic effect when compared to everolimus alone. Conclusion: Everolimus may be used in association with MSCs. However, in our model of LT in the rat, post-transplant MSC injections did not prevent acute rejection, and the association of MSCs with everolimus did not show any synergistic effect. [less ▲]

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See detailPerioperative risk factors of acute kidney injury post liver transplantation: a monocentric retrospective cohort study of 260 patients
Malisoux, Clarisse ULiege; KOCH, Jean-Noël ULiege; MEURISSE, Nicolas ULiege et al

in Transplant International (2021, August), 34(S1 POS315), 312

Aims and Background: Acute kidney injury (AKI) is a major risk factor of poor outcomes after liver transplantation (LT). AKI is usually attributed to post-LT events and drug toxicity. Peri-operative risk ... [more ▼]

Aims and Background: Acute kidney injury (AKI) is a major risk factor of poor outcomes after liver transplantation (LT). AKI is usually attributed to post-LT events and drug toxicity. Peri-operative risk factors of LT-associated AKI remain poorly documented, which hampers the development of personalized preventive strategies. Methods: AKI was assessed by KDIGO criteria based on creatinine changes from baseline to day 5 post LT. 260 single first full-size LTs without any pre-existing renal replacement therapy (RRT) were performed from 2003 to 2018. Incidence of AKI was assessed. Logistic regression determined the risk factors of KDIGO I and II-III AKI. Results: Incidence of AKI KDIGO I and II-III was 30% (78/260) and 25.7% (67/260), respectively. Preoperatively, patients with AKI had higher lab- MELD and Child-Pugh scores, lower serum fibrinogen and albumin levels. Donor type, donor hepatectomy and cold ischemic time were similar between groups. AKI was more frequent in case of marginal donors. LT surgery was longer in the AKI groups. Needs for per-operative blood transfusions were higher in the AKI groups. Rate of post-reperfusion syndrome was higher in AKI groups. Postoperatively, lower hemoglobin levels and higher INR from day 1-5 were associated with AKI. Peak of transaminases were not different between AKI versus non-AKI groups. AKI was associated with longer length of hospital and ICU stays. After multivariate analysis, blood transfusions and post-reperfusion syndrome were risk factors to develop KDIGO I AKI. Pre-operative serum levels of fibrinogen and albumin were risk factors for KDIGO II-III AKI. Finally, “marginal donors” was the only risk factor for both KDIGO I and II-III AKI. Conclusions: LT-associated AKI occurs in >50% of cases. Per-operative hemorrhage and post-operative reperfusion syndrome represent risk factors, particularly in cases of marginal donors. [less ▲]

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See detailLong term follow-up of liver transplant recipients after allogeneic mesenchymal stromal cell infusion
VANDERMEULEN, Morgan ULiege; Mohamed Wais, M; DELBOUILLE, Marie-Hélène ULiege et al

in Transplant International (2021, August), 34(S1 OP282), 45

Background: Some properties of mesenchymal stromal cells (MSCs) might be particularly of interest after organ transplantation. The authors aimed to report herein the long-term results of their first-in ... [more ▼]

Background: Some properties of mesenchymal stromal cells (MSCs) might be particularly of interest after organ transplantation. The authors aimed to report herein the long-term results of their first-in man, prospective, controlled, phase-1 study evaluating the safety of a single third-party MSC infusion after liver transplantation (LT). Methods: Ten liver transplant recipients under standard immunosuppression received 1.5–3 9 106/kg unrelated third-party MSCs on post-operative day 3 ! 2 and were prospectively compared to a control group of 10 liver transplant recipients. Primary endpoints were set to prospectively detect potential delayed side effects of MSC infusion, and particularly occurrence of infections and cancers. As secondary endpoints, liver graft- and patient survivals, graft rejection and function, occurrence of bile duct complications, and development of anti-HLA antibodies against liver- or MSC-donors were studied. Results: There was no difference in overall rates of infection or cancer at 5 years of follow-up between the two groups. There was also no difference in liver graft- and patient survivals, graft rejection, blood liver tests or occurrence of bile duct complications. The prevalence of de novo liver DSA related to HLA-mismatches was two times higher in the MSC group compared to the control group. Three patients of the MSC group (30%) developed at least 1 de novo HLA antibody against MSC-donor. All the de novo class II HLA antibodies against MSC were linked to a shared HLA mismatch between the liver and MSC donors and 75% of HLA class II shared-mismatches led to de novo HLA antibodies. Conclusions: This long-term follow-up confirms the safety of one single MSC infusion after LT. The potential interesting effects of MSC need to be confirmed by prospective studies. The development of anti-HLA antibodies against MSC donor should be further evaluated especially in case of shared HLAmismatchesbetween graft- and MSC-donors, despite the fact that no deleterious effect could be detected. [less ▲]

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See detailAn extension of CityJSON to support point clouds
Nys, Gilles-Antoine ULiege; Kharroubi, Abderrazzaq ULiege; Poux, Florent ULiege et al

in International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2021, June 30), XLII-B4-2021

The combination between dense point clouds and 3D vector objects permits new cartographic representation of urban information. This paper proposes an extension for the CityJSON encoding to support point ... [more ▼]

The combination between dense point clouds and 3D vector objects permits new cartographic representation of urban information. This paper proposes an extension for the CityJSON encoding to support point clouds. Following the 3.0 CityGML specifications, attributes and features are added to the core module of v1.0.1 CityJSON. Two solutions are proposed: inline complex geometries and external link to a remote file. The extended schema can be illustrated in four scenarios: detailed features visualization, fall-back solution in features reconstruction processes, simulating urban climate represented as vector fields, and true-to-life representation solution for complex elements such as solitary vegetation objects. It permits 3D city modelers to handle points clouds in a native way reducing files size and avoiding redundancy. All developments and documentation are available open-source. [less ▲]

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See detailTESSERAE3D: A benchmark for tesserae semantic segmentation in 3D point clouds
Kharroubi, Abderrazzaq ULiege; Van Wersch, Line ULiege; Billen, Roland ULiege et al

in ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2021, June 17), V-2-2021

3D point cloud of mosaic tesserae is used by heritage researchers, restorers, and archaeologists for digital investigations. Information extraction, pattern analysis, and semantic assignment are necessary ... [more ▼]

3D point cloud of mosaic tesserae is used by heritage researchers, restorers, and archaeologists for digital investigations. Information extraction, pattern analysis, and semantic assignment are necessary to complement geometric information. Automated processes that can speed up the task are highly sought after, especially new supervised approaches. However, the availability of labeled data necessary for training supervised learning models is a significant constraint. This paper introduces Tesserae3D, a 3D point cloud benchmark dataset for training and evaluating machine learning models, applied to mosaic tesserae segmentation. It is a publicly available, very high density and colored dataset, accompanied by a standard multi-class semantic segmentation baseline. It consists of about 502 million points and contains 11 semantic classes covering a wide range of tesserae types. We propose a semantic segmentation baseline building on radiometric and covariance features fed to ensemble learning methods. The results delineate an achievable 89% F1 score and are made available under https://github.com/akharroubi/Tesserae3D, providing a simple interface to improve the score based on feedback from the research community. [less ▲]

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See detailFeasibility study of an interferometric Small-Sat to study exoplanets
Dandumont, Colin ULiege; Defrere, Denis ULiege; Loicq, Jerôme ULiege

in Proceedings of SPIE: The International Society for Optical Engineering (2021, June 11), 11852

One of the main goals of exoplanet science is to characterize the atmosphere of rocky exoplanets in the habitable zone of nearby stars. A space-based nulling interferometry, observing in the mid-infrared ... [more ▼]

One of the main goals of exoplanet science is to characterize the atmosphere of rocky exoplanets in the habitable zone of nearby stars. A space-based nulling interferometry, observing in the mid-infrared (3-20 μm), is considered to be one of the most promising solutions to tackle this observing challenge. The LIFE project, a free-flying space-based mid-infrared nulling interferometer, would have this capability. However, several key technologies need to be demonstrated before launching such an ambitious mission. A small space-based mission can be considered as a useful prerequisite. In this paper, we consider three small satellite architectures, two CubeSats, and a PROBA-like satellite. Based on a Bracewell architecture and without free-flying, these monolithic satellites can demonstrate some key components like the null capability and its stability on real targets. The achromatic phase shifter needs also to be demonstrated in space. Based on the scientific capabilities and exoplanet detection yield of these architectures, optical constraints are derived (pointing stability, and optical path difference correction). Orbital simulations, exploring a range of classical orbits for such a satellite, are also discussed. [less ▲]

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See detailPacking dynamics of powders at high temperature
Neveu, Aurélien; Francqui, Filip; Lumay, Geoffroy ULiege

in EPJ Web of Conferences (2021, June 07), 249(12001),

In industrial powder processing, precise control of environmental temperature is difficult especially for large production facilities. A better knowledge of powder behavior modification due to temperature ... [more ▼]

In industrial powder processing, precise control of environmental temperature is difficult especially for large production facilities. A better knowledge of powder behavior modification due to temperature variation will help to improve product quality and consistency. From a fundamental point of view, the effect of temperature on powder flow and packing dynamics is still poorly understood. In particular, because temperature modifies the complex interplay between the different forces acting at the contact between the grains. The packing dynamics of a set of different powders (lactose, cacao and dried milk powder) has been investigated with a tapping experiment. After the filling procedure, the sample is heated and the evolution of the density is measured after each tap. We show that the packing dynamics is drastically influenced even for low temperature changes. Slight increase of temperature affects both the packing kinematics and the packing range characterised by the classical Hausner ratio analysis. Finally, the different physical mechanisms that could explain these modifications are discussed. The results of this preliminary study demonstrate the importance of temperature in powder behaviour and strongly motivate further investigations. [less ▲]

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See detailEffect of grain shape on the dynamics of granular materials in 2D rotating drum
Preud'Homme, Nicolas ULiege; Opsomer, Eric ULiege; Vandewalle, Nicolas ULiege et al

in EPJ Web of Conferences (2021, June 07), 249

We experimentally investigate the effect of the grain shape on the flow of granular material. The grain shape is modified to highlight the effect of grain circularity on granular flow in a 2D rotating ... [more ▼]

We experimentally investigate the effect of the grain shape on the flow of granular material. The grain shape is modified to highlight the effect of grain circularity on granular flow in a 2D rotating drum. Using a laser cutter, we create particles with decreasing circularity. We observe that the effect of grain shape depends on the rotation speed of the drum. For high rotation speed, granular flow is influenced by the packing’s dilatancy whereas, at low rotation speed, packing fraction seems to influence flowing dynamics. We link these two measurements to grain shape in order to explain its effect on granular flow. [less ▲]

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See detailAccompagner la mise en œuvre de l’approche par compétences dans les formations en santé : mise en perspective de plusieurs stratégies de changement
Quesnay, Paul ULiege; Poumay, Marianne ULiege

in Pédagogie Médicale (2021, May 27), 22(Suppl. 1), 15-16

Ces dernières années, les formations des professionnels de la santé ont fait l’objet de réformes visant à faire évoluer leurs curriculums vers une approche par compétences (APC). Or l’APC constitue un ... [more ▼]

Ces dernières années, les formations des professionnels de la santé ont fait l’objet de réformes visant à faire évoluer leurs curriculums vers une approche par compétences (APC). Or l’APC constitue un changement de paradigme pédagogique, avec une nouvelle conception de l’enseignement-apprentissage qui nécessite une révision de l’ingénierie pédagogique et des apprentissages spécifiques pour les coordinateurs et enseignants. La littérature fournit des guides, ainsi que des exemples de transformations curriculaires réussies dans le domaine de la santé mais pointe également un manque de documentation sur la manière dont les changements sont menés. A partir de deux stratégies de changement curriculaire proposées, trois thèmes ont guidé les échanges, à savoir : les points forts et limites de chaque stratégie, leur faisabilité de mise en œuvre, ainsi que les conditions par lesquelles elles peuvent être associées. [less ▲]

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See detailAccompagner la mise en œuvre de l’approche par compétences dans les formations en santé : perspectives d’une stratégie de changement pragmatique portée par un individu tercéisateur dans un institut de formation en ostéopathie
Quesnay, Paul ULiege; Poumay, Marianne ULiege; Gagnayre, Rémi

in Pédagogie Médicale (2021, May 26), 22(Suppl. 1), 152

Contexte : Ces dernières années, les formations des professionnels de la santé ont fait l’objet de réformes visant à faire évoluer leurs curriculums vers une approche par compétences (APC). Ces réformes ... [more ▼]

Contexte : Ces dernières années, les formations des professionnels de la santé ont fait l’objet de réformes visant à faire évoluer leurs curriculums vers une approche par compétences (APC). Ces réformes sont documentées dans leur mise en œuvre. Or l’APC nécessite une révision de l’ingénierie pédagogique et des apprentissages spécifiques pour les coordinateurs et enseignants. Se pose alors la question des stratégies mobilisées pour conduire le changement pédagogique, notamment au regard des ressources disponible au sein de l’institution. But : Analyser les effets d’une stratégie de changement initiée par un individu-tercéisateur pour la mise en œuvre de l’APC dans un institut de formation initiale en ostéopathie, à travers l’évolution des conceptions des coordinateurs. Méthodes : Cette étude qualitative s’inscrit dans une perspective socio-constructiviste, pragmatique et rejoint le cadre de l’éthique des curriculums en santé. Quatre coordinateurs pédagogiques ont participé à des productions pédagogiques et activités réflexives issues des recommandations sur l’APC : élaboration d’un référentiel, révision d’enseignements et d’outils évaluation. Des cartes conceptuelles individuelles ont été élaborées avec les coordinateurs pour suivre l’évolution de leurs conceptions avant et après les activités réflexives. Résultats : Les cartes conceptuelles attestent d’un apprentissage des coordinateurs vers l’APC montrant deux profils d’évolution des conceptions. Les mécanismes d’apprentissages relèvent d’une acculturation à partir d’objets-frontières (travaillés au cours des activités réflexives). Ces cartes conceptuelles, le caractère à la fois individuel et collectif des activités réflexives proposées ainsi que l’action de l’individu-tercéisateur ont permis de soutenir l’apprentissage et le changement. Conclusion : La stratégie étudiée montre à quelles conditions un individu formé à la posture de tercéisateur peut initier des changements pédagogiques en instaurant une dynamique-frontière entre des actions se situant à des niveaux individuels, collectifs et les nécessaires stratégies institutionnelles pour progresser vers l’APC. De même, individus-tercéisateurs, objets et dynamiques frontières constituent une perspective intéressante pour amorcer un changement curriculaire dans d’autres structures de formation qui ne rassembleraient pas toutes les conditions et ressources considérées comme porteuses dans la littérature, ou qui souhaiteraient faire de la formation pédagogique suivie par l’un de leurs enseignants une opportunité de changement. [less ▲]

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See detailIdentification and validation of an extended Stewart-Cazacu micromechanics damage model applied to Ti–6Al–4V specimens exhibiting positive stress triaxialities
Rojas-Ulloa, Carlos; Valenzuela, Marian; Tuninetti, Victor et al

in Proceedings of the Institution of Mechanical Engineers. Part L, Journal of Materials: Design and Applications (2021, May 06), 108(2),

In this research, the Stewart-Cazacu micromechanics coupled damage model is extended and validated adding nucleation and coalescence models as new damage mechanisms. The Ti–6Al–4V titanium alloy is chosen ... [more ▼]

In this research, the Stewart-Cazacu micromechanics coupled damage model is extended and validated adding nucleation and coalescence models as new damage mechanisms. The Ti–6Al–4V titanium alloy is chosen as a suitable hcp ductile material to be modeled using this extended damage law. The characterization of the damage evolution in this alloy is addressed throughout a quasi-static experimental campaign. Damage characterization relies on in-situ X-ray tomography data and Scanning Electron Microscopy (SEM) imaging technique. The validation procedure consists in the implementation into the finite element (FE) research software Lagamine of ULiège and in the comparison of numerical predictions and experimental results. Load-displacement curves and damage related state variables at fracture configuration from smooth and notched bar specimens submitted to tensile tests are analyzed. The nucleation and coalescence model extensions as well as an accurate elastoplastic and damage material parameter identification for Ti–6Al–4V samples are essential features to reach a validated model. The prediction capabilities exhibited for large strains are in good agreement with experimental results, while the near-fracture strains can still be improved. [less ▲]

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See detailConceptual Modeling Versus User Story Mapping: Which is the Best Approach to Agile Requirements Engineering?
Tsilionis, Konstantinos; Maene, Joris; Heng, Samedi ULiege et al

in Lecture Notes in Business Information Processing (2021, May)

User stories are primary requirements artifacts within agile methods. They are comprised of short sentences written in natural language expressing units of functionality for the to-be system. Despite ... [more ▼]

User stories are primary requirements artifacts within agile methods. They are comprised of short sentences written in natural language expressing units of functionality for the to-be system. Despite their simple format, when modelers are faced with a set of user stories they might be having difficulty in sorting them, evaluating their redundancy, and assessing their relevancy in the effort to prioritize them. The present paper tests the ability of modelers to understand the requirements problem through a visual representation (named the Rationale Tree) which is a conceptual model and is built out of a user stories' set. The paper is built upon and extends previous work relating to the feasibility of generating such a representation out of a user stories' set by comparing the performance of the Rationale Tree with the User Story Mapping approach. This is achieved by performing a two-group quantitative comparative study. The identified comparative variables for each method were understandability, recognition of missing requirements/epics/themes, and adaptability. The Rational Tree was not easy to understand and did not perform as anticipated in assisting with the recognition of missing requirements/epics/themes. However, its employment allowed modelers to offer qualitative representations of a specific software problem. Overall, the present experiment evaluates whether a conceptual model could be a consistent solution towards the holistic comprehension of a software development problem within an agile setting, compared to more `conventional' techniques used so far. [less ▲]

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See detailL’enseignement de la compétence relationnelle dans les instituts de formation initiales françaises : un manque de cohérence des curriculums
Quesnay, Paul ULiege; Poumay, Marianne ULiege; Gagnayre, Rémi

in Pédagogie Médicale (2021, May), 22(Suppl. 1), 24-25

Face à l’accroissement des maladies chroniques, un des enjeux est de développer des compétences d’éducation chez les soignants pour permettre de transférer des compétences au patient. En ostéopathie, les ... [more ▼]

Face à l’accroissement des maladies chroniques, un des enjeux est de développer des compétences d’éducation chez les soignants pour permettre de transférer des compétences au patient. En ostéopathie, les recommandations internationales témoignent de l’intérêt porté à ces enjeux à travers les activités de conseil de l’ostéopathe. Néanmoins, il est difficile de savoir en pratique comment se situe le conseil par rapport à l’information, à la communication ou à l’éducation, et des études précédentes pointent un besoin de mieux former les ostéopathes. En France, la dernière réforme (décrets) concernant la formation initiale a défini une compétence relationnelle qui inclut l'éducation du patient. Elle est peu documentée quant à son intégration dans les curriculums, et sur la formation des praticiens à l'éducation du patient. But : Déterminer comment les formations initiales en ostéopathie intègrent la compétence relationnelle, et questionner la place attribuée à l’éducation du patient. Méthode : Un questionnaire en ligne a été conçu suivant les 7 étapes recommandées par l’AMEE. Il a été administré à l’ensemble des instituts de formations initiale français (n=28). 8 instituts ont répondu à l’enquête. Résultats : La compétence relationnelle est apparue dans plusieurs enseignements, renforcée par l'apprentissage clinique à toutes les années de formations. Les enseignements n'étaient cependant pas spécifiques à cette compétence et leur volume d'heures était relativement faible. L'éducation des patients était considérée comme faisant partie de la compétence relationnelle et importante pour les répondants mais était peu mise en œuvre. Conclusions : Il semble y avoir un non-alignement entre les résultats de l'apprentissage, l'enseignement et l'évaluation. Les pratiques actuelles de formation ne sont pas suffisantes pour soutenir la compétence relationnelle, en particulier en ce qui concerne l'éducation des patients. Les résultats ont mis en évidence la nécessité de clarifier les décrets et d'améliorer la formation des formateurs. C'est à ces conditions que les écoles d'ostéopathie françaises pourront pleinement intégrer la compétence relationnelle. [less ▲]

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See detailSensitivity-enhanced localized surface plasmon resonance biosensing format dedicated for point-of-care testing tools
Hastanin, Juriy ULiege; Lenaerts, Cedric ULiege; Fleury-Frenette, Karl ULiege et al

in Proceedings of SPIE: The International Society for Optical Engineering (2021, April 16)

The main requirement for a point-of-care health monitoring tools is that it should involve relatively simple and inexpensive equipment ensuring acceptable accuracy of diseases early diagnostic. Quite ... [more ▼]

The main requirement for a point-of-care health monitoring tools is that it should involve relatively simple and inexpensive equipment ensuring acceptable accuracy of diseases early diagnostic. Quite commonly in practice, their main function is only to trigger an ‘alarm’ signal, when a specific biomarker of disease is detected in the sample. The affinity label-free biosensing involving surface plasmonic resonance (SPR) phenomena appears to be one of the most appropriate approaches for the above requirements. In our research, we focus on theoretical and experimental investigations of optional plasmonic-related biosensing formats easy to be integrated in lab-on-chip devices involving conventional planar SPR biosensing. One of such detection formats, mentioned in our earliest publications, involves localized surface plasmon resonance (LSPR) spectroscopy at the frustrated total internal reflection conditions (LSPR_TIR). In this paper, we report on the numerical and experimental study of LSPR_TIR spectroscopy of gold nanoparticles (NPs) structures with a relatively high density of NPs, manufactured using two different microfabrication methods: the conventional nano-sphere lithography, and the original one, involving the direct pulse laser writing. The last technology, developed by our research team, provides powerful and cost effective tools for flexible patterning of the disposable multichannel biochip with array of SPR and LSPR probes. The obtained results demonstrate a significant improvement in the LSPR wavelength sensitivity to sample refractive index. In addition, experimental investigations reveal a relatively efficient conversion of the incident light wave polarization that can be attributed to a relatively high efficiency of electromagnetic coupling between closely spaced NPs. [less ▲]

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See detailCompact laser altimeter dedicated to drone ballistic carriers
Hastanin, Juriy ULiege; Martin, Nicolas; Montfort, Francis ULiege et al

in Proceedings of SPIE: The International Society for Optical Engineering (2021, April 15)

Over the past few decades, the use of low cost Miniature Unmanned Aerial Vehicles (MUAV), as well as Micromechanical Flying Insects (MFI) in targets aerial surveillance and reconnaissance has experienced ... [more ▼]

Over the past few decades, the use of low cost Miniature Unmanned Aerial Vehicles (MUAV), as well as Micromechanical Flying Insects (MFI) in targets aerial surveillance and reconnaissance has experienced almost an exponentially growth not only in conventional military areas, but also in civil, industrial and aerospace applications. Despite obvious inherent advantages, such as a very attractive cost-efficiency ratio and a low risk to the drone operator safety, MUAV/MFI based technologies still present multiple challenges. The major drawback of conventional MUAV/MFI is that a relatively low on-board energy storage capacity and an inherent weakness of the MUAV/MFI propulsion drive systems. It results in a relatively low flight speed and an inability to fly in bad meteorological conditions, such as strong wind and could be critical for many applications, such as the forest fires or nuclear accident zones monitoring. In order to overcome these drawbacks, we propose to deliver MUAV/MFI to the designated target zone using ballistic carriers, such as mortar round or infantry man-portable unguided rocket. Accordingly, our research team intends to develop a prototype of MUAV/MFI ballistic carrier involving standard mortar rounds of 81 mm and 120 mm calibers. In this paper, we report the results of theoretical and experimental investigations on the MUAV/MFI ballistic carriers being developed by our research team and we address specifically the concept of compact laser altimeter dedicated to the ballistic carriers, as well as the first proof-of-concept experimental investigations, demonstrating its practical feasibility. One of the main challenges facing the implementation of the proposed concept of the mortar launched altimeter is to ensure its reliable operation after extremely high launch shock accelerations. This requirement determines the optical concept and materials selection and optimization, as well as the accuracy of alignment of the optical system. Recent mortar gun tests, performed in the frame of our experimental investigations, demonstrated that the key optical and electronic elements and sub-systems of the developed altimeter prototype can withstand launch accelerations of at least 5000g, as well as typical shock accelerations during parachute deployment phase. In additional, it should be noted that the fuze front surface area available for the placement of rangefinder optical lens assemblies is limited by military standards requirements, as well as by the air intake duct of the air drive turbine used as a power generator, that also poses some challenges for integrating the altimeter into mortar fuze head. The experimental investigations of the first altimeter prototype developed in compliance with these requirements, demonstrated the enabling range finding up to 1000 m, when operating at night time environments. [less ▲]

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See detailValidating a French-language version of Health Communication Assessment Tool: Content validity, test-retest reliability, interrater agreement, and implications for further development
Diep, Anh Nguyet ULiege; Servotte, Jean-Christophe; Dardenne, Nadia ULiege et al

in Advances in Simulation (2021, April 12), 6

Introduction The assessment of the communication skills of nurses in clinical settings bears both practical and educational significance. Despite the significance of communication skills to realize high ... [more ▼]

Introduction The assessment of the communication skills of nurses in clinical settings bears both practical and educational significance. Despite the significance of communication skills to realize high-quality patient-care, the development and validation of such an instrument applicable in different cultural contexts is still lacking and faces certain challenges. Additionally, the assessment of nurse-patient communication, which is dynamic and context-bounded, requires a fine-grained instrument, while not compromising the complexities of the skills under assessment. The aim of the present study was to test a French-language version of the Health Communication Assessment Tool (HCAT) (Campbell et al., 2013), on a French-speaking sample in Belgium against different measures of content relevance, validity, and reliability. Based on cognitive fluency perspective, we developed three simulated scenarios registering three levels of skill performance, including low, medium, and high demonstration. Thus, the psychometric properties of the HCAT instrument can be thoroughly examined. Methods Ten experts in communication and 52 nurse educators participated in the study. Firstly, the instrument was translated from English to French using back-translation technique. After semantic equivalence was agreed upon, the experts rated the relevance of the 22 items making up the HCAT, resulting in the removal of one culturally-irrelevant item. Subsequently, the experts and nurse educators rated the communication skills of the nurse in three scenarios. To ensure test-retest reliability, the nurse educators rated the scenarios twice within a four-week interval. The experts’ ratings were used as the gold standard when examining the reliability of the nurse educators’ ratings. Results & Discussion Exploratory and confirmatory factor analyses showed that the instrument could distinguish three aspects of communication skills, i.e. professional presentation, empathy, and trust building. Two-way random intraclass correlation coefficients (ICCs), ranging from 0.917 to 0.982, revealed that interrater agreement was excellent for consistency and absolute average-measures. However, at absolute single-measure, an ICC=0.425 suggested adequate interrater reliability for the medium-performed scenario, which decreased in low-performed (ICC=0.348) and high-performed (ICC=0.176) scenarios. Further, more than half of the items displayed poor test-retest reliability. [less ▲]

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See detailOsteomodulin Impacts Positively The Bone Remodeling Process In Osteoarthritis
Zappia, Jérémie ULiege; Van der Cruyssen, Renée; Sanchez, Christelle ULiege et al

in Bone Reports (2021, April), 14(Suppl 1), 2352-1872

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See detailL'autodéfense intellectuelle, une pratique philosophique nécessaire aussi en démocratie
Herla, Anne ULiege; Jeanmart, Gaëlle ULiege; Compere, Aurore ULiege

in Diotime-l'Agora: Revue Internationale de Didactique de la Philosophie (2021, April), 88

Les ateliers d'autodéfense intellectuelle présentés dans cet article visent à s'attaquer à certaines expressions et pratiques langagières typiques de nos démocraties, qui finissent par les éroder. Ils ... [more ▼]

Les ateliers d'autodéfense intellectuelle présentés dans cet article visent à s'attaquer à certaines expressions et pratiques langagières typiques de nos démocraties, qui finissent par les éroder. Ils tendent à nous rendre collectivement attentif·ve·s aux idées et aux mots tellement ressassés qu'ils sont vidés de leur sens, aux subterfuges propres à noyer les poissons et à enfumer les esprits, aux discours qui prennent l'apparence de la raison sans en adopter la rigueur. Ces réflexes prophylactiques sont l'hygiène de base d'une démocratie saine, et ils s'appliquent autant aux discours qui nous entourent qu'à ceux que nous tenons sur nos propres activités, nouvelles pratiques philosophiques comprises. [less ▲]

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See detailOsteomodulin impacts positively the bone remodeling process in osteoarthritis
Zappia, Jérémie ULiege; Van der Cruyssen, Renee; Sanchez, Christelle ULiege et al

in Osteoarthritis and Cartilage (2021, April), 29(Suppl 1), 111

Osteomodulin (OMD) is a Small Leucine Rich Proteoglycan (SLRP) highly specific of the bone extracellular matrix. Its production and expression are impaired in subchondral bone sclerosis associated with ... [more ▼]

Osteomodulin (OMD) is a Small Leucine Rich Proteoglycan (SLRP) highly specific of the bone extracellular matrix. Its production and expression are impaired in subchondral bone sclerosis associated with osteoarthritis (OA). This study aimed to investigate the effects OMD on osteoblasts and osteoclasts in culture. [less ▲]

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See detailDevelopment of a primary skeletal muscle cell culture model from human muscle biopsies
Florin, Antoine ULiege; Lambert, Cécile ULiege; Sanchez, Christelle ULiege et al

in Osteoarthritis and Cartilage (2021, April), 29(Suppl), 108

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See detailPotential Role of Epithelial Protein Disulphide Isomerases in Crohn’s Disease Fibrosis
Vieujean, Sophie ULiege; Hu, Shurong; Bequet, Emeline ULiege et al

in Acta Gastro-Enterologica Belgica (2021, March 03)

Background and aims: Intestinal fibrosis is a common complication of Crohn’s disease (CD) characterized by an accumulation of fibroblasts differentiating into activated myofibroblasts secreting excessive ... [more ▼]

Background and aims: Intestinal fibrosis is a common complication of Crohn’s disease (CD) characterized by an accumulation of fibroblasts differentiating into activated myofibroblasts secreting excessive extracellular matrix. In in-vitro experiments, this myofibroblastic differentiation is elicited by a whole series of factors among which transforming growth factor β1 (TGF-β1) seems to play a key role. The potential role of the intestinal epithelium in this fibrotic process remains poorly defined. Methods: We performed a pilot proteomic study comparing the proteome of surface epithelium isolated by laser-capture microdissection in normal and fibrotic zones of resected ileal CD strictures (13 zones collected in 5 patients). The pro-fibrotic role of selected epithelial proteins was investigated through in-vitro experiments using HT-29 epithelial cells and a CCD-18Co fibroblast to myofibroblast differentiation model. Results: Proteomic study revealed an endoplasmic reticulum (ER) stress proteins increase in the epithelium of CD ileal fibrotic strictures, including Anterior gradient protein 2 homolog (AGR2), Protein disulphide isomerase A6 (PDIA6) and Endoplasmic reticulum resident protein 44 (ERP44) which are 3 protein disulphide isomerases. In HT-29 cells, tunicamycin-induced ER stress triggered AGR2, PDIA6, ERP44 as well as TGF β1 intracellular expression and their secretion. Supernatant of these HT-29 cells, pre-conditioned by tunicamycin (Tm), led to a myofibroblastic differentiation when applied on CCD-18Co fibroblasts. The application of blocking agents for AGR2, PDIA6, ERP44 or TGF β1 in the supernatant of these Tm pre conditioned HT-29 cells, attenuated the myofibroblastic differentiation induced by this supernatant, suggesting a pro-fibrotic role of these secreted epithelial proteins. Conclusions: The development of CD fibrotic strictures may involve ER stress in epithelial cells, releasing a whole set of proteins into their environment, including AGR2, PDIA6, ERP44 as well as TGF-β1, which could exercise a pro-fibrotic role through a paracrine action. [less ▲]

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See detailThermodynamic optimality principles in Earth sciences
Schymanski, Stanislaus J.; Dewals, Benjamin ULiege; Dijkstra, Henk A. et al

in Geophysical Research Abstracts (2021)

Ecohydrological systems are a result of long-term co-evolution of soils, biota and atmospheric conditions, and often respond to perturbations in non-intuitive ways. Their short-term responses can be ... [more ▼]

Ecohydrological systems are a result of long-term co-evolution of soils, biota and atmospheric conditions, and often respond to perturbations in non-intuitive ways. Their short-term responses can be explained and sometimes predicted if we understand the underlying dynamic processes and if we can observe the initial state precisely enough. However, how do they co-evolve in the long-term after a change in the boundary conditions? In 1922, Alfred Lotka hypothesised that the natural selection governing the evolution of biota and composition of ecosystems may be obeying some thermodynamic principles related to maximising energy flow through these systems. Similar thoughts have been formulated for various components of the Earth system and individual processes, such as heat transport in the atmosphere and oceans, erosion and sediment transport in river systems and estuaries, the formation of vegetation patterns, and many others. Different thermodynamic optimality principles have been applied to predict or explain a given system property or behaviour, of which the maximum entropy production and the maximum power principles are most widespread. However, the different studies did not use a common systematic approach for the formulation of the relevant system boundaries, state variables and exchange fluxes, resulting in considerable ambiguity about the application of thermodynamic optimality principles in the scientific community. Such a systematic framework has been developed recently and can be tested online at: https://renkulab.io/projects/stanislaus.schymanski/thermodynamic_optimality_blueprint In the present study, we illustrate how such a common framework can be used to classify and compare different applications of thermodynamic optimality principles in the literature, and discuss the insights gained and key criteria for a more rigorous testing of such principles. [less ▲]

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See detailMulti-level governance and sanctuary cities: the case of Liege (Belgium) and undocumented migrants
Mescoli, Elsa ULiege

in Journal of Immigrant and Refugee Studies (2021)

Debates about migration issues are spread across various levels of contemporary Belgian society, where a process of policy restriction is in place, as well as federal discourse aimed at discouraging ... [more ▼]

Debates about migration issues are spread across various levels of contemporary Belgian society, where a process of policy restriction is in place, as well as federal discourse aimed at discouraging arrivals. This climate affects not only newcomers, but also those who have been residing in the country for years without managing to regularize their residence status. Within this global framework, local initiatives have developed to support migrants and their needs, as well as to propose broader political claims. In this article, I will discuss these issues by analyzing the case study of a group of undocumented migrants that occupied uninhabited buildings in Liège—with the help of a network of mobilized citizens and associations that are active in the territory— in order to launch a claims process for regularization. The local government of the city tolerates and supports the initiatives of the group to a certain extent, thus making Liège a “sanctuary city”, i.e. both a secure space for migrants and a setting for resistance. Such a socio-political space takes shape within a context of multi-level governance targeting migration issues (reception and integration), which is characterized by gaps in policy implementation and subsidiarity. Within this setting, undocumented migrants exert their agency and claim human and civil rights through a series of concrete mobilization actions. The aim of this article is to show how local action affects the process of migration governance in Belgium. [less ▲]

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See detailAssessment of lumped physically-based numerical models of dyke breaching
Schmitz, Vincent ULiege; Wylock, Grégoire; El Kadi Abderrezzak, Kamal et al

in Geophysical Research Abstracts (2021)

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See detailChallenging construction industry with C&DW: opportunities and limits
Courard, Luc ULiege; Zhao, Zengfeng ULiege; Hubert, Julien ULiege

in Revista Hormigon (2021), (H59), 33-45

Construction and Demolition Waste (C&DW) comprises the largest waste stream in the European Union (EU), with relatively stable amounts produced over time and high recovery rates: it is estimated at one ... [more ▼]

Construction and Demolition Waste (C&DW) comprises the largest waste stream in the European Union (EU), with relatively stable amounts produced over time and high recovery rates: it is estimated at one third of total wastes generated in the EU. Although this may suggest that the construction sector is highly circular, scrutiny of waste management practices reveals that C&DW recovery is largely based on backfilling operations and low-grade recovery, such as using recycled aggregates in road sub-bases. These wastes are usually recovered as secondary raw materials after a recycling process resulting in the production of recycled sands and aggregates. Researches have been performed to show how it is possible to encourage and support the use of these recycled materials: preparation process and selection are fundamental for increasing capability of recycling. Analysis of recycled bricks and tiles sands and fine particles has also been tested as substitution product in concrete design. A quantitative analysis is proposed for five North West European (NWE) countries: Belgium, France, Germany, Luxembourg and the Netherlands, where barriers are pointed out. The construction industry will be definitively affected by C&DW recycling for promoting circular economy in the coming years. [less ▲]

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See detailIncreased resectability after simultaneous portal and hepatic vein embolization (PVE/HVE) compared to PVE alone in patients with small FLRS – a DRAGON group analysis
Heil, J; Korenblik, R; Heid, F et al

in HPB (2021), 23(S3), 674-751

Introduction: Major liver resections in patients with a small Future Liver Remnant (FLR) can only be performed safely after induction of adequate FLR-hypertrophy to reduce the risk of post-hepatectomy ... [more ▼]

Introduction: Major liver resections in patients with a small Future Liver Remnant (FLR) can only be performed safely after induction of adequate FLR-hypertrophy to reduce the risk of post-hepatectomy liver failure (PHLF). Hypertrophy induced by Portal Vein Embolization (PVE) is slow and 20-30% of patients are not resected after this procedure. Combining Portal and Hepatic Vein Embolization (PVE/HVE) accelerates FLR hypertrophy, whether this increases resectability is studied in this analysis. Methods: All participating centers in the DRAGON COLLABORATIVE that had already performed >5 PVE/ HVE between 2016 and 2019 were asked to contribute cases of PVE/HVE or PVE. Osirix MD was used for volumetric assessment. Multivariable analysis was performed for the endpoints: resectability, FLR hypertrophy, and major complications (Clavien-Dindo >IIIA). Results: From 7 DRAGON centers, 39 PVE/HVE and 160 PVE cases were included. After PVE/HVE, resectability (90% vs. 68%, p=0.007) and FLR hypertrophy (59% vs. 48%, p=0.02) were higher than PVE alone. 90-day mortality (3% vs. 16%, p=0.15) and major complications (26% vs. 34%, p=0.55) did not significantly differ between groups. PVE/HVE was not a significant risk factor for major complications, but it was an independent predictor for survival and hypertrophy. Results were confirmed via multivariable analysis. Conclusion: PVE/HVE resulted in increased resectablity and liver growth compared to PVE alone. Complications and mortality rate did not differ between PVE/HVE and PVE. Superiority of PVE/HVE over PVE will be investigated in the prospective DRAGON trials. [less ▲]

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See detailLe “voile commun à tous meschans”. La justification de l’intolérance par la rhétorique du dévoilement dans la polémique catholique (France et Pays-Bas habsbourgeois, 1580–1594)
Goderniaux, Alexandre ULiege

in Loxias: Littératures Française et Comparées (2021), Colloques - 18

This paper offers a comparative study of the polemical texts produced by the Catholic party in France and in the Southern Low Countries at the end of the 16th century. It focuses on the use of a specific ... [more ▼]

This paper offers a comparative study of the polemical texts produced by the Catholic party in France and in the Southern Low Countries at the end of the 16th century. It focuses on the use of a specific rhetoric strategy: the disclosure. In the case of France, this survey shows how this argument is linked to those of fear, war and truth within a deeply intolerant discourse which legitimizes a radical and intransigent hunt. Then, it studies how, on the contrary, the controversy produced in the Low Countries uses the rhetoric strategy of disclosure in a much more limited way, focused on the figure of a single enemy. [less ▲]

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See detailBelgian prospective registry on laparoscopic liver surgery compared to open procedures: 3-year snapshot of multi centric activity
Lucidi, V; Riva, P; D'Hondt, M et al

in HPB (2021), 23(S3), 752-846

The Belgian Registry on Laparoscopic Liver Surgery is a prospective, non-compulsory, online registry of laparoscopic (LLS) and open (OLS) liver procedures, endorsed in 2016 by the Belgian Section of ... [more ▼]

The Belgian Registry on Laparoscopic Liver Surgery is a prospective, non-compulsory, online registry of laparoscopic (LLS) and open (OLS) liver procedures, endorsed in 2016 by the Belgian Section of Hepato-Biliary and Pancreatic Surgery. The primary aim is to assess the evolution of laparoscopic liver surgery compared to the standard open approach in Belgium. Methods: Participating centers included, through a secured SSL server (www.brells.org), all consecutive liver surgeries from 2017 to 2019. Demographic, pre- intra- and postoperative data of all consecutive LLS and OLS were recorded. Results: In total 13 centers participated to the study. 1531 procedures were recorded (841 LLS and 690 OLS) in 1408 patients. Demographics of patients were similar between LLS and OLS. Indication for surgery were 57% liver metastases (49% LLS, 51% OLS), 29% primary liver tumors (57% LLS, 43% OLS) and 16% benign diseases (73%LLS, 27% OLS). Exclusive local thermal ablation (LA) accounted for 118 procedures. Excluding LA from analysis, rate of major hepatectomies was 18,2% (n=258) and median Ghent difficulty score was 5,6 (4,8 LLS vs 6,5 OLS). LLS were converted to OLS in 3,3% of cases. Overall morbidity and mortality were significantly lower in LLS compared to OLS respectively 27% vs 53% and 0,6% vs 2,9%. Length of hospital stay was significantly shorter in LLS (Median 4 vs 7 days). Conclusions: LLS are wide spreading in Belgium accounting globally to 55% of all liver surgeries. In selected patients, LLS are safe, advantageous and reproducible in major HPB centers. A low morbidity has been prospectively confirmed. [less ▲]

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See detailSTAR-3D Clinical Trial Results: Improved performance and safety
Uyttendaele, Vincent ULiege; Knopp, Jennifer L.; Desaive, Thomas ULiege et al

in IFAC-PapersOnLine (2021), 10.1016/j.ifacol.2021.10.304(15), 1-580

Glycemic control (GC) has improved outcomes for intensive care unit (ICU) patients. However, the increased risk of hypoglycemia and glycemic variability due to inter- and intra- patient variability make ... [more ▼]

Glycemic control (GC) has improved outcomes for intensive care unit (ICU) patients. However, the increased risk of hypoglycemia and glycemic variability due to inter- and intra- patient variability make safe, effective GC difficult. Stochastic TARgeted (STAR) GC framework is a unique, patient-specific, risk-based dosing protocol directly accounting for both inter- and intra- patient variability using a stochastic model of future patient variability. A new tri-variate (3D) stochastic model, developed and validated in virtual trials to provide more accurate future predictions of insulin sensitivity (SI), is clinically evaluated. STAR-3D was implemented as standard care at the Christchurch Hospital ICU, New Zealand, between April 2019 and January 2021. In total, 567 patients (33276 hours) were treated. The overall median [IQR] BG achieved was 6.7 [6.0 7.8] mmol/L with 76% BG in the 4.4-8.0 mmol/L target band. Importantly, there were only 0.3% BG < 4.0 mmol/L (mild hypoglycemia) and no incidence of severe hypoglycemia (BG < 2.2 mmol/L). These outcomes were achieved with median [IQR] 4.0 [2.0 6.0] U/h insulin and median [IQR] nutrition delivery of 99 [80 100]% goal feed (GF). Similar safety and performance BG outcomes were obtained at a per-patient level, suggesting STAR-3D successfully provided safe, effective control for all patients, regardless of patient condition. Compared to the original version of STAR, STAR-3D provided improved safety and efficacy, while achieving higher nutrition delivery. The new 3D stochastic model in STAR-3D provided higher safety and efficacy for all patients in this large clinical trial, despite using higher insulin rates than its predecessor to provide greater nutrition delivery. STAR-3D thus better captured patient-specific condition and variability to provide improved GC outcomes. [less ▲]

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See detailDoes Facemask Impact Diagnostic During Pulmonary Auscultation?
Uyttendaele, Vincent ULiege; GUIOT, Julien ULiege; Chase, J. Geoffrey et al

in IFAC-PapersOnLine (2021), 54(15), 1-580

Facemasks have been widely used in hospitals, especially since the emergence of the coronavirus 2019 (COVID-19) pandemic, often severely affecting respiratory functions. Masks protect patients from ... [more ▼]

Facemasks have been widely used in hospitals, especially since the emergence of the coronavirus 2019 (COVID-19) pandemic, often severely affecting respiratory functions. Masks protect patients from contagious airborne transmission, and are thus more specifically important for chronic respiratory disease (CRD) patients. However, masks also increase air resistance and thus work of breathing, which may impact pulmonary auscultation and diagnostic acuity, the primary respiratory examination. This study is the first to assess the impact of facemasks on clinical auscultation diagnostic. Lung sounds from 29 patients were digitally recorded using an electronic stethoscope. For each patient, one recording was taken wearing a surgical mask and one without. Recorded signals were segmented in breath cycles using an autocorrelation algorithm. In total, 87 breath cycles were identified from sounds with mask, and 82 without mask. Time-frequency analysis of the signals was used to extract comparison features such as peak frequency, median frequency, band power, or spectral integration. All the features extracted in frequency content, its evolution, or power did not significantly differ between respiratory cycles with or without mask. This early stage study thus suggests minor impact on clinical diagnostic outcomes in pulmonary auscultation. However, further analysis is necessary such as on adventitious sounds characteristics differences with or without mask, to determine if facemask could lead to no discernible diagnostic outcome in clinical practice. [less ▲]

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See detailPeripheral nerve injuries 3 months after a critical COVID-19 pneumonia.
MALENGREAUX, Christophe ULiege; MINGUET, Pauline ULiege; COLSON, Camille ULiege et al

in Critical Care (2021), 25(Suppl 1),

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See detailPost‐intensive care syndrome after critical COVID‐19 pneumonia.
Bougard, Laurine ULiege; MINGUET, Pauline ULiege; COLSON, Camille ULiege et al

in Intensive Care Medicine Experimental (2021), 9(1),

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See detailUse of Vandenberg and Kuse Mental Rotation Test to Predict Practical Performance of Sinus Endoscopy
ROGISTER, Florence ULiege; Pottier, Laurence ULiege; El Haddadi, Ilyas et al

in Archives of Public Health (2021)

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See detailThe mid Upper Palaeolithic (Gravettian) sequence of Mitoc-Malu Galben (Romania): New fieldwork between 2013 and 2016 - Preliminary results and perspectives
Nigst, Philip R.; Libois, Timothée ULiege; Haesaerts, Paul et al

in Quaternary International (2021), 587-588

This paper presents preliminary results of fieldwork conducted at the Upper Palaeolithic open-air site Mitoc-Malu Galben in northeastern Romania. The site has a ~14m deep loess-paleosol sequence with a ... [more ▼]

This paper presents preliminary results of fieldwork conducted at the Upper Palaeolithic open-air site Mitoc-Malu Galben in northeastern Romania. The site has a ~14m deep loess-paleosol sequence with a rather high climatic resolution. The chronostratigraphy is well established and embedded in this long sequence are abundant archaeological remains, mostly attributed to the Aurignacian and Gravettian. Our fieldwork between 2013 and 2016 provided new samples of the main Aurignacian and Gravettian layers. Here we provide an overview of our fieldwork activities, the generated archaeological collections, and present a preliminary analysis of raw material economy and blank production and core exploitation strategies of the Gravettian assemblages. We also discuss the Mitoc-Malu Galben Gravettian in its wider regional context and implications for the Aurignacian-Gravettian transition. [less ▲]

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See detailImpact of virtual reality training in disaster medicine
Chevalier, Sabrina ULiege; Dubois, Nadège

in Archives of Public Health (2021)

Background Crisis and disastrous events might have various impact in terms of human, material and financial costs [1]. Disaster medicine aims at optimizing resources management which the number of victims ... [more ▼]

Background Crisis and disastrous events might have various impact in terms of human, material and financial costs [1]. Disaster medicine aims at optimizing resources management which the number of victims is high and resources limited, notably by using triage systems [2]. However, many difficulties persist when it comes to practice triage in real life [3], re-emphasizing the importance to train efficiently the healthcare professionals. In this context, simulation appears to be offer real interests. Within the framework of the INTERREG project "International Knowledge and Information Centre" (IKIC), a virtual reality environment simulating a train accident has been created and funded. We tested the impact of this training on participants’ satisfaction and learning. Materials and methods This quantitative study included 17 nurses specialised in emergency medical aid. These students participate in our training course which proceeded through several steps: pre-course e-learning, pre-briefing, briefing, virtual reality scenario and debriefing. Questionnaires were distributed before and after the simulation to assess satisfaction, self-efficacy and key learnings. The focus of the training was on the pre-triage of victims. Results Our training increased participants' sense of self-efficacy (p-value = 0.04). We also noticed high levels of satisfaction and confidence in acquired learning and a high sense of presence. The majority (70.59%) of students felt that the environment had a positive impact on their performance. However, knowledge did not change after the training (p-value = 0.44). Conclusions In this experience, using a simulation training with a virtual reality environment had a positive impact on participants satisfaction and perceived self-efficacy. The fidelity of the environment was underlined by the participants. In future research, it would be interesting to compare such virtual reality training with conventional training. [less ▲]

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See detailNumerical models for the static analysis of cable structures used in airborne wind turbines
Roccia, B. A.; Cosimo, A.; Preidikman, S. et al

in Mechanisms and Machine Science (2021), 94

In this work, the authors present two different multibody models for static analysis of airborne wind turbines (AWTs) cables. These wind turbines are composed of three main components: a buoyant blimp ... [more ▼]

In this work, the authors present two different multibody models for static analysis of airborne wind turbines (AWTs) cables. These wind turbines are composed of three main components: a buoyant blimp with a standard turbine rotor fixed within its shell, tethers connecting the system to earth ground, and a rotating base station. The tethers (or cables) are critical parts due to their multiple functions (aerostat control and power electric transmission, among others). The models/procedure presented in this article allows determining equilibrium points of the space tethers, which can be used for starting a global dynamic analysis of the complete system. An accurate initializing solution is essential for the convergence of the successive numeric non-linear aeroelastic analysis of AWTs. On these bases, the authors present two models of increasing complexity: i) a lumped-parameter model formulated in $$\mathbb {R}^{3}$$, and ii) a finite element model based on a kinematically exact formulation of beams in SE(3). Both models are validated comparing results against well-documented problems (e.g. the elastic catenary). © 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG. [less ▲]

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See detailSimulation of sliding friction of spherical rigid bodies subject to multiple impact collisions
Cavalieri, F. J.; Cosimo, A.; Sanchez, E. et al

in Mechanisms and Machine Science (2021), 94

This work investigates the dynamics of spherical rigid bodies subject to multiple impact collisions and sliding friction. The contact problem is solved with a mixed dual formulation based on an augmented ... [more ▼]

This work investigates the dynamics of spherical rigid bodies subject to multiple impact collisions and sliding friction. The contact problem is solved with a mixed dual formulation based on an augmented Lagrangian technique. The equations of motion and the multiple impact collisions are solved in the frame of the nonsmooth generalized-$$\alpha $$ time integrator scheme. In order to consider the mechanical and geometrical properties of the spheres, a rigid body formulation with translational and rotational degrees of freedom is implemented. Finally, in order to assess the numerical performance of the proposed methodology, a multiple impact collisions motion of three spheres over a rigid plane is studied. © 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG. [less ▲]

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See detailL'aventure cartésienne de la substance. « Ego autem substantia» dans l'ordre des raisons
Dubouclez, Olivier ULiege

in Revue Internationale de Philosophie (2021)

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See detailDevelopment of a space spectropolarimeter for full Stokes parameters retrieval.
Vasilescu, Bogdan ULiege; Nazé, Yaël ULiege; Loicq, Jerôme ULiege

in Proceedings of SPIE: The International Society for Optical Engineering (2020, December 13), 11451

This paper presents recent advancements in the study of a new concept of space spectropolarimeter. The instrument, based on a triple prismatic structure from a birefringent material, avoids the need of ... [more ▼]

This paper presents recent advancements in the study of a new concept of space spectropolarimeter. The instrument, based on a triple prismatic structure from a birefringent material, avoids the need of rotating components and may cover the entire Stokes vector for a very broad wavelength band. The analysis of the concept in noise-free conditions has proved its consistency. Further simulations for different geometries of the modulator are presented. The results allow identifying critical values for the main parameters. Moreover, the previous analysis of the instrument in noisy conditions is completed with the impact study of the spectral resolution, dimension of pixels and signal to noise ratio. [less ▲]

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See detailOptimizing Outcomes of Acute Leukemia After Transplants with Single Unrelated Cord Blood Units Selected According to Current International Recommendations for Cell Dose and HLA Match
Rafii, Hanadi; Kenzey, Chantal; Volt, Fernanda et al

in Bone Marrow Transplantation (2020, December 11), 55(4), 170-171

Selection of sCBU based on recommended cell dose and HLA criteria results in good engraftment and survival. When cell dose (TNC ≥ 2.5x107/kg) is respected, other factors such as HLA disparity have an ... [more ▼]

Selection of sCBU based on recommended cell dose and HLA criteria results in good engraftment and survival. When cell dose (TNC ≥ 2.5x107/kg) is respected, other factors such as HLA disparity have an impact on outcomes. [less ▲]

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See detailSeed shadows of northern pigtailed macaques within a degraded forest fragment, Thailand
Gazagne, Eva ULiege; Pitance, Jean-Luc ULiege; Savini, Tommaso ULiege et al

in Revue de Primatologie (2020, December 10), 11

Determining seed shadow (i.e. seed deposition pattern of a plant population) produced by frugivores is difficult to evaluate by direct observations, although of paramount importance to understand their ... [more ▼]

Determining seed shadow (i.e. seed deposition pattern of a plant population) produced by frugivores is difficult to evaluate by direct observations, although of paramount importance to understand their effectiveness as seed dispersal agents in degraded habitat. We developed a modeling approach of seed shadows incorporating field-collected data on a troop of 141 ± 10 individuals of northern pigtailed macaques (Macaca leonina) inhabiting a degraded forest fragment in Thailand, by implementing a mechanistic model of seed deposition with random components. We parameterized the model with macaque feeding behavior (i.e. consumed fruit species, seed treatments), gut and cheek pouch retention time, location of feeding sites and sleeping sites, monthly photoperiod, and movement patterns based on monthly native fruit availability using Hidden Markov models (HMM). We found that northern pigtailed macaques dispersed a majority of medium- to large-seeded species across large distances (mean > 500 m, maximum distance of 2300 m), promoting genetic mixing and colonization of plantation forests. Additionally, the macaques produced complementary seed shadows, with a sparse distribution of seeds spat out locally (mean > 50 m, maximum distance of 870 m) that probably ensures seedling recruitment of the immediate plant populations. Macaques’ large dispersal distance reliability is often underestimated and overlooked; however, their behavioral flexibility places them among the last remaining dispersers of large seeds in disturbed habitats. Our study shows that this taxon is likely to maintain significant seed dispersal services and promote forest regeneration in degraded forest fragments. [less ▲]

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See detailDevelopment of the SPECULOOS exoplanet search project
Sebastian, Daniel ULiege; Pedersen, P. P.; Murray, C. A. et al

in Proceedings of SPIE: The International Society for Optical Engineering (2020, December 01), 11445

SPECULOOS (Search for habitable Planets EClipsing ULtra-cOOl Stars) aims to perform a transit search on the nearest (< 40 pc) ultracool (< 3000K) dwarf stars. The project's main motivation is to discover ... [more ▼]

SPECULOOS (Search for habitable Planets EClipsing ULtra-cOOl Stars) aims to perform a transit search on the nearest (< 40 pc) ultracool (< 3000K) dwarf stars. The project's main motivation is to discover potentially habitable planets well-suited for detailed atmospheric characterisation with upcoming giant telescopes, like the James Webb Space Telescope (JWST) and European Large Telescope (ELT). The project is based on a network of 1m robotic telescopes, namely the four ones of the SPECULOOS-Southern Observatory (SSO) in Cerro Paranal, Chile, one telescope of the SPECULOOS-Northern Observatory (SNO) in Tenerife, and the SAINTEx telescope in San Pedro Martir, Mexico. The prototype survey of the SPECULOOS project on the 60 cm TRAPPIST telescope (Chile) discovered the TRAPPIST-1 system, composed of seven temperate Earth-sized planets orbiting a nearby (12 pc) Jupiter-sized star. In this paper, we review the current status of SPECULOOS, its first results, the plans for its development, and its connection to the Transiting Exoplanet Survey Satellite (TESS) and JWST. [less ▲]

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See detailReview and scientific prospects of high-contrast optical stellar interferometry
Defrere, Denis ULiege; Absil, Olivier ULiege; Berger, J.-P et al

in Proceedings of SPIE: The International Society for Optical Engineering (2020, December), 11446

High-contrast optical stellar interferometry generally refers to instruments able to detect circumstellar emission at least a few hundred times fainter than the host star at high-angular resolution ... [more ▼]

High-contrast optical stellar interferometry generally refers to instruments able to detect circumstellar emission at least a few hundred times fainter than the host star at high-angular resolution (typically within a few \lambda/D). While such contrast levels have been enabled by classical modal-filltered interferometric instruments such asVLTI/PIONIER, CHARA/FLUOR, and CHARA/MIRC the development of instruments able to fi lter out the stellar light has signi cantly pushed this limit, either by nulling interferometry for on-axis observations (e.g., PFN, LBTI, GLINT) or by o -axis classical interferometry with VLTI/GRAVITY. Achieving such high contrast levels at small angular separation was made possible thanks to signi cant developments in technology (e.g., adaptive optics, integrated optics), data acquisition (e.g., fringe tracking, phase chopping), and data reduction techniques (e.g., nulling self-calibration). In this paper, we review the current status of high-contrast optical stellar interferometry and present its key scienti c results. We then present ongoing activities to improve current ground-based interferometric facilities for high-contrast imaging (e.g., Hi-5/VIKING/BIFROST of the ASGARD instrument suite, GRAVITY+) and the scienti c milestones that they would be able to achieve. Finally, we discuss the long-term future of high-contrast stellar interferometry and, in particular, ambitious science cases that would be enabled by space interferometry (e.g., LIFE, space-PFI) and large-scale ground-based projects (PFI). [less ▲]

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See detailPerformance study of interferometric small-sats to detect exoplanets:Updated exoplanet yield and application to nearby exoplanets
Dandumont, Colin ULiege; Kammerer, Jens; Defrere, Denis ULiege et al

in Proceedings of SPIE: The International Society for Optical Engineering (2020, December), 11446

Nulling interferometry is considered as one of the most promising solutions to spectrally characterize rocky exoplanets in the habitable zone of nearby stars. It provides both high angular resolution and ... [more ▼]

Nulling interferometry is considered as one of the most promising solutions to spectrally characterize rocky exoplanets in the habitable zone of nearby stars. It provides both high angular resolution and starlight mitigation. It requires however several technologies that need to be demonstrated before a large interferometry space-based mission flies. A small-sat mission is a good technological precursor. Based on a Bracewell architecture, this unique satellite can demonstrate some key components (null capability, fiber injection, achromatic phase shifter). Scientific capabilities of such a mission are presented. An exoplanet detection yield is derived, and we show that the detection of exoplanets around nearby stars is feasible. [less ▲]

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See detailMise au point d’un modèle de culture original de cellules musculaires squelettiques à partir de biopsies musculaires humaines
Florin, Antoine ULiege; Lambert, Cécile ULiege; Sanchez, Christelle ULiege et al

in Revue du Rhumatisme (2020, December), Volume 87(Supplément 1),

The objective of this work was to develop a culture model of primary skeletal muscle cells obtained from human muscle biopsies.

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See detailCaractérisation de l’expression des alarmines et des variants A-SAA dans la polyarthrite rhumatoïde débutante
CIREGIA, Federica ULiege; Nys, Gwenael; COBRAIVILLE, Gaël ULiege et al

in Revue du Rhumatisme (2020, December), 87(S1), 126

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See detailSecondary fracture prevention in hip fracture patients: 6-year impact of a Fracture Liaison Service
NEUPREZ, Audrey ULiege; DEROISY, Rita ULiege; LEONARD, Yvette ULiege et al

in Osteoporosis International (2020, December), 31(S1), 199-200

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See detailCONSENSUS STATEMENT ON INTRA-ARTICULAR INJECTIONS OF PLATELET RICH PLASMA FOR THE MANAGEMENT OF KNEE OSTEOARTHRITIS
Eymard, F; Ornetti, P; Maillet, J et al

in Osteoporosis International (2020, December), 31(S1), 194

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