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See detailÉVOLUTION DE LA TENEUR EN EAU LE LONG D’UNE TOPOSEQUENCE FORESTIERE ARGILO-LIMONEUSE
Deraedt, Deborah ULiege; Colinet, Gilles ULiege; Degré, Aurore ULiege

in Milieux Poreux et Transferts Hydriques (in press)

For the hydrological modeling of forested watersheds, the understanding of the forest hydrodynamic is essential. This study focusses on the hydrology of a Belgian forested plot with high stoniness and ... [more ▼]

For the hydrological modeling of forested watersheds, the understanding of the forest hydrodynamic is essential. This study focusses on the hydrology of a Belgian forested plot with high stoniness and steep slope. The soil water content is monitored at several positions on the toposequence and at different depth. During rain events, peak in soil water content are observed in different depth depending on the position along the toposequence. [less ▲]

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See detailArrêt(s) sur image(s) : usages et pratiques du photogramme
Thonon, Jonathan ULiege

in MethIS: Méthodes et Interdisciplinarité en Sciences Humaines (in press)

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See detailsynthéticité et intuition en mathématiques contemporaines : Kant au-delà de Kant
Mazurkiewicz, Stany ULiege

in Eikasia. Revista de Filosofia. (in press)

Ce texte entend réévaluer l'idée de "pure synthèse intellectuelle" que l'on trouve chez Kant. Celle-ci cadre avec la pratique mathématique et métamathématique postérieure à Kant. Elle permet de dépasser l ... [more ▼]

Ce texte entend réévaluer l'idée de "pure synthèse intellectuelle" que l'on trouve chez Kant. Celle-ci cadre avec la pratique mathématique et métamathématique postérieure à Kant. Elle permet de dépasser l'alternative entre l'intuitionnisme développé dans la Critique de la raison pure et la fondation de la mathématique sur une logique formelle analytique. Je montre que cette idée convient à Bolzano et à Dedekind, dont je soutiens que les projets sont irréductibles à du logicisme et qui sont dès lors bien plus "kantiens" qu'il n'y paraît. [less ▲]

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See detailTwo-loop-induced neutrino masses: A model-independent perspective
Aristizabal Sierra, Diego ULiege

in PoS Proceedings of Science (in press)

We disucuss Majorana neutrino mass generation mechanisms at the two-loop order. After briefly reviewing the systematic classification of one-loop realizations, we then focus on a general two-loop ... [more ▼]

We disucuss Majorana neutrino mass generation mechanisms at the two-loop order. After briefly reviewing the systematic classification of one-loop realizations, we then focus on a general two-loop classification scheme which provides a model-independent catalog for neutrino mass models at the two-loop order [less ▲]

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See detailPaper Formats of the Mamluk Period: The Contribution of Mamluk Chancery Paper
Bauden, Frédéric ULiege

in Journal of Islamic Manuscripts (in press)

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See detailThe role of conservators: an international survey on conservation within contemporary art collections
D'Haenens, Manon ULiege

in CeROArt: Conservation, Exposition, Restauration d'Objets d'Art (in press)

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See detailEffect of antimicrobial drug on lung microbiota in healthy dogs.
Fastrès, Aline ULiege; Vangrinsven, Emilie ULiege; Tutunaru, Alexandru-Cosmin ULiege et al

in Journal of Veterinary Internal Medicine (in press)

In human and dogs, baseline differences in lung microbiota (LM) have been associated with important clinical features in chronic lung diseases (CLD) and there is growing evidence that an altered LM ... [more ▼]

In human and dogs, baseline differences in lung microbiota (LM) have been associated with important clinical features in chronic lung diseases (CLD) and there is growing evidence that an altered LM contributes to disease pathogenesis. The common use of antibiotic drugs throughout the management of CLD likely represents a major confounding factor in the study of the LM. However, the effect of antibiotic treatment on the LM in healthy individuals has not been specifically investigated yet. The aim of the present study was to assess the short and medium-term effect of an oral treatment with a large spectrum antimicrobial drug on the LM in healthy dogs. Six healthy experimental beagle dogs were included. Amoxycillin/clavulanic acid (AC) was administered at a dose of 20 mg/kg twice daily for 10 days. In each dog, bronchoalveolar lavage fluid (BALF) was collected at 3 different timepoints: before administration of AC (J0) and immediately (J10) as well as 16 days (J26) after interruption of AC. In each BALF, total and differentiated cell counts were obtained and metagenetic analyses were performed on the V1-V3 hypervariable region of 16S rDNA after total bacterial DNA extraction and sequencing on a MiSeq Illumina sequencer. Taxonomical assignation and microbiota community analysis were done with MOTHUR V1.35 with an OTU clustering distance of 0.03. Statistical comparisons between events for microbiota community and BALF cell counts were made using Friedman test and post-hoc t-tests with Bonferroni correction. Statistical differences in bacterial population relative abundance between timepoints were assessed using a mixed linear model with FDR correction for multiple comparisons. Administration of AC did not induce significant changes in BALF cellular counts and had no effect on the richness, evenness and alpha diversity. Bacteroidetes and Proteobacteria abundance increased from J0 to J10 (mean: 12.0 to 24.1, and 12.3 to 26.2%, respectively; p<0.001) and decreased at J26 (13.1 and 9.3%; p<0.001). Firmicutes abundance decreased from J0 to J10 (45.6 to 18.3%; p<0.001) and increased at J26 (28.8%; p<0.001). Actinobacteria abundance increased at J26, compared with J0 and J10 (43.7 compared with 23.2 and 23.5% respectively; p<0.001). We failed to show significant differences between timepoints at the level of genera and species. In conclusion, in healthy dog, oral administration of a commonly used large spectrum antimicrobial drug induces significant changes in microbial population abundance at the phyla level. Most but not all of these changes normalize within 2 weeks after discontinuation of the drug. [less ▲]

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See detailNeuro-functional correlates of the protective effects of exercise against cocaine sensitization and dopamine D2 receptors density: a [18F]Fallypride microPET study.
Becker, Guillaume ULiege; Lespine, Louis-Ferdinand ULiege; Serrano Navacerrada, Maria Elisa ULiege et al

in Molecular Imaging and Biology (in press)

Preclinical studies suggest that free access to a running wheel can attenuate behavioural effects of addictive drugs such as psychomotor sensitization to cocaine in rodents. This phenomenon has an ... [more ▼]

Preclinical studies suggest that free access to a running wheel can attenuate behavioural effects of addictive drugs such as psychomotor sensitization to cocaine in rodents. This phenomenon has an integral role in the process of drug addiction in craving and relapse (Steketee and Kalivas, 2011). Free wheel-running was recently shown to be efficacious at preventing the initiation or the long-term expression of psychomotor sensitization to cocaine in mice or rats (Diaz et al., 2013; Geuzaine and Tirelli, 2014). In the present study, we investigated the neuro-functional correlates of the protection against psychomotor sensitization to cocaine afforded by free wheel-running on dopaminergic neurotransmission, using microPET imaging with [18F]Fallypride, a Dopamine 2 receptor (D2R) antagonist. Sixty-four 28-day-old female C57BL/6J mice were randomly assigned to one of the two housing conditions, defined by the presence or the absence of a running wheel in the cage over a 6-week pre-testing period. Since mice from the two types of housing received either saline (controls) or cocaine (8 mg/kg, i.p.) during testing (9 once-daily sessions to establish sensitization plus 1 single session to test its expression), a basic 2x2 randomized blocks design was generated (2-way ANOVA and planned comparisons; n=10). Experimentation lasted 85 days, with a 42-day period of pre-testing and a 3-week interval preceding the test for long-term expression of sensitization (LTES). All mice underwent a microPET (Focus 120, Siemens) the day after the LTES. The microPET protocol consisted of a 60 min. dynamic acquisition after the injection of 10 MBq of [18F]Fallypride in the tail vein. Wheel-running strongly and significantly attenuated LTES (interaction) to cocaine (Cohen’s d=1.63; t(21)=3.75, p<.001) and cocaine-treated mice exhibited a clear-cut and significant increase (main effect) of the [18F]Fallypride BP (d=0.88, t(31)=2.45, p =.02). Wheel-running induced an overall moderate-sized decrease (main effect) of the [18F]Fallypride BP, but without achieving statistical significance (d=0.64, t(31)=1.79, p =.08). These findings suggest that LTES is associated with an increase of the [18F]Fallypride BP in the mouse striatum, probably reflecting an increase in postsynaptic D2R density in this region. Also, the protecting effect of free running on psychomotor sensitization goes together with a decrease in D2R density in the striatum of exercised mice. We intend to complement the present study with an identical experiment to reach a total number of 80 mice (n=20). This will confer to our study a sufficient power (80%) for the main effect of wheel-running exercise on [18F]Fallypride BP to be detected at an alpha-level of 5%. Finally, autoradiography studies, performed on the same mice with [18F]Fallypride, will strengthen our in vivo results. [less ▲]

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See detailA 100 M GROUND RESOLUTION GLOBAL DAILY COVERAGE EARTH OBSERVATION MISSION
Loicq, Jerôme ULiege; Clermont, Lionel ULiege; Dierckx, Wouter et al

in Proceedings of SPIE : The International Society for Optical Engineering (2017), Proc. of SPIE Vol. 10563

PROBA-V has been successfully launched on 7th May 2013 and is providing a global monitoring in the continuity of the SPOT-VEGETATION mission. The progress in terms of ground resolution between Spot VGT ... [more ▼]

PROBA-V has been successfully launched on 7th May 2013 and is providing a global monitoring in the continuity of the SPOT-VEGETATION mission. The progress in terms of ground resolution between Spot VGT and PROBA-V is a factor 3 (1 km to 1/3 km ground resolution product). The User Community requirements for the next generation of global monitoring are a 100 m ground resolution product. This means an additional factor 3 improvement, but in a short time frame (5 years). After success of the PROBA-V mission, the Belgian Science Policy (BELSPO) initiates a PROBA-V Successor feasibility study. This study was undertaken by VITO and CSL to identify potential tracks to achieve a follow-on mission which is expected to be relevant for the User Community. The mission analyses for each of these tracks was evaluated. Today the PROBA-V mission lifetime is expected to expire by mid of 2018. Since the interest for global land monitoring is expected to continue in the future, this study proposes mission requirements and a shortlist of optimal mission scenarios for a follow-on mission in this short time frame. The goal of such a new PROBA-V mission is clear: it should ensure the data continuity of global vegetation monitoring, while taking the opportunity to further improve the data quality. Data continuity is essential for understanding long term trends of land use that may affect the global equilibrium of the planet (in the context of scarcity for land or food, natural disasters, climate change). As for added value, a fine example is the improvement of spatial resolution when comparing PROBA-V with the spatial resolution in SPOT-VEGETATION products. An improvement in spatial resolution towards a full 100m product is considered by the user community as the main target for a PROBA-V follow-on mission. [less ▲]

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See detailMarket analysis of recycled sands and aggregates in North-West Europe: drivers and barriers
Delvoie, Simon ULiege; Zhao, Zengfeng ULiege; Michel, Frédéric ULiege et al

in Conference Series Earth and Environmental Science (2019)

Construction and demolition wastes (C&DW) are estimated at one third of total wastes generated in the European Union (EU) and represent the main flux in volume. Inert materials (e.g. concrete, bricks ... [more ▼]

Construction and demolition wastes (C&DW) are estimated at one third of total wastes generated in the European Union (EU) and represent the main flux in volume. Inert materials (e.g. concrete, bricks, tiles and ceramics) constitute the largest fraction of construction and demolition wastes. These wastes can be recovered as secondary raw materials after a recycling process resulting in the production of recycled sands and aggregates. The market for recycled sands and aggregates is however complex and sensitive. It can be affected by many parameters and may be very variable from one region to another, even in the same country. A quantitative analysis of some market variables is carried out in five NW European countries: Belgium, France, Germany, Luxembourg and the Netherlands. For achieving this analysis, attention is paid to the following data/parameters: generation of inert construction and demolition wastes, production of recycled sands and aggregates and production of natural sands and aggregates. Since the market of recycled products is also governed by transportation costs (mainly transported by road), the study has also compiled data on the density of recycling plants for construction and demolition wastes, the density of pits and quarries extracting natural materials, the density of inert landfills and taxes applied for C&DW landfilling. National/regional legislation and requirements are also included in the analysis. Based on the compiled data and objective reasons, the market of recycled sands and aggregates is more developed and more suitable in the Netherlands and in Flanders (North of Belgium) than in the other investigated countries/regions. [less ▲]

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See detailL’analyse des acides gras érythrocytaires maternels en début de grossesse révèle un faible index oméga-3
Hoge, Axelle ULiege; Bernardy, Florence; Donneau, Anne-Françoise ULiege et al

in Nutrition Clinique et Metabolisme (2018, December), 32(4),

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See detailInternet of Things: learning and practices. Application to Smart City
Debauche, Olivier ULiege; Mahmoudi, Saïd; Mahmoudi, Sidi Ahmed

in IEEE Explore (2018, November 28)

Internet of Things is becoming widely present in our daily life. In fact, more and more devices able to interact together have been recently designed and launched in the market. Learning Internet of ... [more ▼]

Internet of Things is becoming widely present in our daily life. In fact, more and more devices able to interact together have been recently designed and launched in the market. Learning Internet of Things technologies is becoming unavoidable in education. In this paper, we propose a practical approach allowing to progressively learn, by practice the essential concepts of Internet of Things applied to Smart Cities. From basic knowledge of python language and the use of microcontrollers Pycom such as LoPy, students can develop skills and also smart applications in the field of Internet of Things. [less ▲]

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See detailThe use of Platelet-Rich Plasma (PRP) to treat chronic tendinopathies: a technical analysis
Kaux, Jean-François ULiege; Emonds-Alt, Thibault ULiege

in British Journal of Sports Medicine (2018, November), 52(Suppl 3), 1

Platelet-rich plasma (PRP) is blood plasma with a high concentration of autologous platelets which constitute an immense reservoir of growth factors. The clinical use of PRP is widespread in various ... [more ▼]

Platelet-rich plasma (PRP) is blood plasma with a high concentration of autologous platelets which constitute an immense reservoir of growth factors. The clinical use of PRP is widespread in various medical applications. Although highly popular with athletes, the use of PRP for the treatment of tendinopathies remains scientifically controversial, particularly due to the diversity of products that go by the name of ‘PRP.’ To optimize its use, it is important to look at the various stages of obtaining PRP. In this literature review, we take a closer look at eight parameters which may influence the quality of PRP: 1. anticoagulants used to preserve the best platelet function, 2. the speed of centrifugation used to extract the platelets, 3. the platelet concentrations obtained, 4. the impact of the concentration of red and white blood cells on PRP actions, 5. platelet activators encouraging platelet degranulation and, hence, the release of growth factors, and 6. the use or nonuse of local anesthetics when carrying out infiltration. In addition to these parameters, it may be interesting to analyze other variables such as 7. the use of ultrasound guidance during the injection with a view to determining the influence they have on potential recovery. In conclusion, there is a lack of standardization in PRP preparation technique for tendinopathies. However, it appears that the use of a platelet concentration lower than 5 times the baseline and avoidance of leukocytes should be preferred. [less ▲]

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See detailNew concepts in liver regeneration mechanisms in human severe alcoholic steatohepatitis.
Lejeune, A; Starkel, P; Louvet, A et al

in Hepatology (2018, October 18), 68(S1), 1378

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See detailSpatio-temporal reasoning in CIDOC CRM: an hybrid ontology with GeoSPARQL and OWL-Time
Nys, Gilles-Antoine ULiege; Van Ruymbeke, Muriel ULiege; Billen, Roland ULiege

in CEUR Workshop Proceedings (2018, October 13), 2230

Semantic description of cultural heritage information is already widely structured through CIDOC CRM and its different extensions. This shared understanding of cultural heritage information has already ... [more ▼]

Semantic description of cultural heritage information is already widely structured through CIDOC CRM and its different extensions. This shared understanding of cultural heritage information has already proved its usefulness. Until now, despite its spatial and temporal data management proposition, lack standardization limited the possibilities in terms of reasoning and workability. This paper proposes to increase the potentiality offered by the current scheme by including GeoSPARQL and OWL-Time in the framework. The result, as hybrid ontology, allows concurrent spatial and temporal handling. These are used to provide a near-full data management for complex spatio-temporal reasoning and querying through SPARQL queries. Example queries depicting the strength of the approach and allowing knowledge discovery in huge archaeological datasets illustrate its benefits [less ▲]

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See detailComet 66P/du Toit: A Near Earth Main Belt Comet?
Yang, Bin; Opitom, Cyrielle; Jehin, Emmanuel ULiege et al

in Bulletin of the American Astronomical Society (2018, October 01), 50

We obtained medium-resolution and high-resolution spectra of the near-Earth Jupiter family comet (JFC) 66P/du Toit from 300 to 2500 nm with X-shooter/VLT and UVES/VLT on 2018 July 01, 07 and 13 ... [more ▼]

We obtained medium-resolution and high-resolution spectra of the near-Earth Jupiter family comet (JFC) 66P/du Toit from 300 to 2500 nm with X-shooter/VLT and UVES/VLT on 2018 July 01, 07 and 13, respectively. In addition, we obtained a series of narrow-band images of 66P between 2018 May and July with TRAPPIST-South. Comet 66P is one of the weakly active JFCs that were identified by Fernandez & Sosa (2015) as having the highest probability of coming from the Main Belt. Our main goal is to investigate the composition of this comet via measuring the gaseous species in the UV and visible and to study its dust properties via measuring the continuum over a broad wavelength range. Additionally, we aim to measure the ortho-to-para abundance ratio of NH2 to constrain the formation conditions of this comet. I will present our spectroscopic observations as well as the photometric observations of 66P. I will discuss whether this comet shows any clear difference in terms of its volatile profile or its dust profile compared to other typical JFCs. [less ▲]

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See detailA high resolution spetrum of comet C/2016 R2 (PanSTARRS) with the ESO VLT
Jehin, Emmanuel ULiege; Opitom, Cyrielle; Hutsemekers, Damien ULiege et al

in Bulletin of the American Astronomical Society (2018, October 01), 50

The returning long period comet C/2016 R2 (PanSTARRS) was discovered on September 7, 2016 at 6.3 au from the Sun. While it was already showing a 20" coma at this large distance (Weryk and Wainscoat 2016 ... [more ▼]

The returning long period comet C/2016 R2 (PanSTARRS) was discovered on September 7, 2016 at 6.3 au from the Sun. While it was already showing a 20" coma at this large distance (Weryk and Wainscoat 2016), it is only in December 2017 that it was found that this comet had a very unusual composition. From radio observations the comet appeared to be very rich in CO and very poor in HCN (Wierzchos and Womack 2018) and its optical spectrum was dominated by CO[SUP]+[/SUP] and more surprisingly N[SUB]2[/SUB][SUP]+[/SUP] emission bands (Cochran and McKay 2018), while most of the emission bands usually detected in the optical spectrum of comets were not detected. In order to investigate in detail its coma in the optical, we obtained a total of 6 hours of Director Discretionary Time on C/2016 R2 with UVES, the high resolution optical spectrograph of the ESO Very Large Telescope, between February 11 and 16, 2018. We used two different settings to optimally cover the whole optical spectrum (326-1060 nm) with a resolving power of 80.000. We report on those observations. We detect strong emissions of the ions CO[SUP]+[/SUP] and N[SUB]2[/SUB][SUP]+[/SUP], and also several CO[SUB]2[/SUB][SUP]+ [/SUP]bands, but no H[SUB]2[/SUB]O[SUP]+[/SUP] . We detect emission lines of the radicals CN, C[SUB]2[/SUB] and C[SUB]3[/SUB] but they are very weak. We computed from these spectra the N[SUB]2[/SUB][SUP]+[/SUP] / CO[SUP]+[/SUP] / CO[SUB]2[/SUB][SUP]+[/SUP] ratios in the coma of the comet which put some constraints on the comet formation models, and compared those values to other comets. The forbidden oxygen [OI] lines are detected, allowing to measure the ratio between the green line and the red doublet which provides a way to determine the abundance of CO and CO[SUB]2[/SUB] relative to H[SUB]2[/SUB]O. For the first time we report the detection of the nitrogen [NI] forbidden doublet at 5197.9 and 5200.2 Å in the coma of a comet, confirming the high abundance of nitrogen in this comet. Interestingly we also detect a line at 9850 Å which could be one of the carbon [CI] forbidden lines but we do not detect the other line of the doublet at 9823 Å. Because of the strong N[SUB]2[/SUB][SUP]+[/SUP] emissions, it was also a unique opportunity to measure the [SUP]14[/SUP]N/[SUP]15[/SUP]N isotopic ratio directly in N[SUB]2[/SUB], the main nitrogen reservoir in the solar nebula. [less ▲]

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See detailTechnology and aging : new opportunities for a better life
PETERMANS, Jean ULiege; Piccard, Sébastien ULiege; Boulanger, G

in European Geriatric Medicine (2018, October), 9(supp1),

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See detailAge-related changes in circadian sleep-wake regulation: Impact on cognitive performance and cerebral correlates
Schmidt, Christina ULiege; Reichert, Carolin; Deantoni, Michele ULiege et al

in Journal of Sleep Research. Supplement (2018, September 26)

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See detailTOWARDS AN ONTOLOGY FOR THE STRUCTURING OF REMOTE SENSING OPERATIONS SHARED BY DIFFERENT PROCESSING CHAINS
Nys, Gilles-Antoine ULiege; Kasprzyk, Jean-Paul ULiege; Hallot, Pierre ULiege et al

in International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2018, September 19), XLII(4), 483-490

This paper proposes an ontology to structure and describe processing chains in the remote sensing field. These chains are made up of elementary elements (operations) organized in collections. The ... [more ▼]

This paper proposes an ontology to structure and describe processing chains in the remote sensing field. These chains are made up of elementary elements (operations) organized in collections. The collection notion, including information about order and repeatability of the elements, is widely defined by using the relations between their constituting items and relations to the whole data store. Applications of the ontology are illustrated with web services provided by a platform for users and providers of processing chains. A graphical interface facilitates data integration in a RDF triple store. Thanks to the management of metadata (ISO19115-3), relevant information can be requested by intelligent search engines. Graph analysis, errors management and consistency rules are computed in order to gather coherent information from the different sources. Results of these analyses are then used by machine learning algorithms for new knowledge discovery. [less ▲]

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See detailNutrient digestibility in Algerian local young rabbits according to dietary energy
Saidj, Dahia; Moula, Nassim ULiege; Kadi et al

in ANIMAL (2018, September 02)

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See detailShould we bank our sleep and clocks? How and why creating large multimodal databases
Vandewalle, Gilles ULiege

in Journal of Sleep Research (2018, September)

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See detailAbaloparatide for risk reduction of nonvertebral and vertebral fractures in postmenopausal women with osteoporosis: a network meta-analysis
Reginster, Jean-Yves ULiege; Bianic, F.; Campbell, R et al

in Arthritis and Rheumatology (2018, September), 70(S9), 2308

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See detailRelationship between cerebral amyloid burden and cerebral microstructure measured by quantitative MRI in healthy aging
Villar Gonzalez, Pamela ULiege; Chylinski, Daphné ULiege; Narbutas, Justinas ULiege et al

in Frontiers (2018, August 22)

The presence of Alzheimer’s disease (AD) biomarkers in the brain of healthy older individuals has been associated with decreased myelin and increased iron deposits in the brain (Bartzokis, 2011). Novel ... [more ▼]

The presence of Alzheimer’s disease (AD) biomarkers in the brain of healthy older individuals has been associated with decreased myelin and increased iron deposits in the brain (Bartzokis, 2011). Novel Magnetic Resonance Imaging (MRI) techniques, like quantitative multiparameter mapping (MPM), allow to gain insight in the microstructure of the brain and could help to address the link between myelin and iron in the brain (Callaghan et al., 2014) and AD biomarkers. Our aim was, therefore, to relate the amount of myelin and iron content to the cortical amyloid burden. We acquired MPM sequences in a 3T scanner and [18F]flutemetamol positron-emission tomography (PET) images in 55 cognitively healthy adults (35 women), aged 50-70 (mean: 59.5 ± 5.5). We used MPM to infer myelin content, based on magnetization transfer saturation (MT) and longitudinal relaxation rate (R1), and iron content, based on effective transverse relaxation rate (R2*). Cortical beta-amyloid burden was measured with [18F]flutemetamol PET. Multiparameter maps were created and normalised with the hMRI (Balteau et al., 2018) toolbox for MATLAB (The Mathworks Inc, Natick, MA, USA). Correlations between MPM maps and amyloid burden were conducted with SPM12 framework (Wellcome Trust Centre for Neuroimaging, London) p<.05 FWE corrected. As expected (Dean et al., 2017), we observed a link between increased amyloid burden and increased iron content in frontal areas mainly but also in parietal and occipital areas. However, there was an unexpected negative correlation between amyloid burden and white matter iron content in the left superior temporal area. Moreover, a positive association between amyloid burden and myelin content was found in the frontal and temporal lobes in both grey and white matter. Furthermore, R1 values, which depend on both iron and myelin storage, present positive correlations with amyloid burden in both grey and white matter of frontal, temporal and occipital areas. The finding that increased iron in frontoparietal and occipital areas are associated with increased amyloid burden fits with previous studies. However, current results also indicate that individuals with higher cortical amyloid burden have higher myelin water fraction in frontotemporal areas. This would suggest that, in cognitively healthy middle-aged individuals, the presence of amyloid in the brain, which represents a risk factor for AD, is accompanied by both cerebral microstructural decline in some areas and enhanced –possibly compensatory- microstructure properties in other areas. [less ▲]

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See detailStates of knowledge: a basis for spatio-temporal model of cultural heritage information
Hallot, Pierre ULiege; Billen, Roland ULiege

in CEUR Workshop Proceedings (2018, August)

Modelling cultural heritage information is a common requirement when considering heritage documentation. The digital documentation is now considered as the first step to heritage conser15 vation. The ... [more ▼]

Modelling cultural heritage information is a common requirement when considering heritage documentation. The digital documentation is now considered as the first step to heritage conser15 vation. The replication of a geographical information model to cultural heritage information is not trivial. Most of proposed spatio-temporal information models do not encompass the diversity of some complex situations encountered in heritage documentation. This diversity remains both on the strong relation of heritage information with time and the necessity for researchers to record not only physical remains but also the planned projects that may never occurred or vir20 tually reconstructed objects for which geometric information is incomplete. In this paper we propose a spatio-temporal information model that considers heritage objects that existed in the past, continue to exist, were planned or planned and never realized. This diversity is of a high importance for heritage research where the relationships between actual space and past states of planned project is their main concern. The developed model is based on the distinction between the existence, the physical realization and the geometrical definition of modelled objects. The proposed model defines the concept of state knowledge which is a cumulative representation of the documented information related to build heritage. 2012 ACM Subject Classification Information systems [less ▲]

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See detailIdentification method of an advanced constitutive law for nickel-based alloy Haynes 230 used in solar receivers
Morch, Hélène ULiege; Duchene, Laurent ULiege; Habraken, Anne ULiege

in Journal of Physics. Conference Series (2018, August), 1063

A model to study panels of thin tubes of Haynes 230 nickel alloy used in solar receivers has been developed. The thermo-mechanical behavior of these tubes is simulated using an advanced model capable of ... [more ▼]

A model to study panels of thin tubes of Haynes 230 nickel alloy used in solar receivers has been developed. The thermo-mechanical behavior of these tubes is simulated using an advanced model capable of representing specific characteristics such as viscosity, kinematic and cyclic hardening, static recovery, or dynamic recovery. The constitutive law implemented is a finite-element visco-plastic model based on the work of Chaboche. Due to its complexity, the model uses a significant number of parameters that need to be identified at several temperatures. The aim of this article is to define an efficient method for the identification of the parameters of this Chaboche model adapted to cyclic thermo-mechanical loading. [less ▲]

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See detailHi-5: A potential high-contrast thermal near-infrared imager for the VLTI
Defrere, Denis ULiege; Ireland, M.; Absil, Olivier ULiege et al

in Proceedings of SPIE : The International Society for Optical Engineering (2018, July 09), 10701

Hi-5 is a high-contrast (or high dynamic range) infrared imager project for the VLTI. Its main goal is to characterize young extra-solar planetary systems and exozodiacal dust around southern main ... [more ▼]

Hi-5 is a high-contrast (or high dynamic range) infrared imager project for the VLTI. Its main goal is to characterize young extra-solar planetary systems and exozodiacal dust around southern main-sequence stars. In this paper, we present an update of the project and key technology pathways to improve the contrast achieved by the VLTI. In particular, we discuss the possibility to use integrated optics, proven in the near-infrared, in the thermal near-infrared (L and M bands, 3-5 μm) and advanced fringe tracking strategies. We also address the strong exoplanet science case (young exoplanets, planet formation, and exozodiacal disks) offered by this wavelength regime as well as other possible science cases such as stellar physics (fundamental parameters and multiplicity) and extragalactic astrophysics (active galactic nuclei and fundamental constants). Synergies and scientific preparation for other potential future instruments such as the Planet Formation Imager are also briefly discussed. © 2018 SPIE. [less ▲]

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See detailCharacterizing the atmosphere of Proxima b with a space-based mid-infrared nulling interferometer
Defrere, Denis ULiege; Léger, A.; Absil, Olivier ULiege et al

in Proceedings of SPIE : The International Society for Optical Engineering (2018, July 09), 10701

Proxima b is our nearest potentially rocky exoplanet and represents a formidable opportunity for exoplanet science and possibly astrobiology. With an angular separation of only 35 mas (or 0.05 AU) from ... [more ▼]

Proxima b is our nearest potentially rocky exoplanet and represents a formidable opportunity for exoplanet science and possibly astrobiology. With an angular separation of only 35 mas (or 0.05 AU) from its host star, Proxima b is however hardly observable with current imaging telescopes and future space-based coronagraphs. One way to separate the photons of the planet from those of its host star is to use an interferometer that can easily resolve such spatial scales. In addition, its proximity to Earth and its favorable contrast ratio compared with its host M dwarf (approximately 10-5 at 10 microns) makes it an ideal target for a space-based nulling interferometer with relatively small apertures. In this paper, we present the motivation for observing this planet in the mid-infrared (5-20 microns) and the corresponding technological challenges. Then, we describe the concept of a space-based infrared interferometer with relatively small (<1m in diameter) apertures that can measure key details of Proxima b, such as its size, temperature, climate structure, as well as the presence of important atmospheric molecules such as H2O, CO2, O3, and CH4. Finally, we illustrate the concept by showing realistic observations using synthetic spectra of Proxima b computed with coupled climate chemistry models. © 2018 SPIE. [less ▲]

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See detailDigital Holographic Interferometry in the Long-Wave Infrared Range for Measuring Large Deformations of Space Components under Thermal-Vacuum Testing
Vandenrijt, Jean-François ULiege; Thizy, Cédric ULiege; Languy, Fabian ULiege et al

in Proceedings (2018, July 09), 2018(2), 534

Holographic interferometry at around 10 µm wavelengths has many advantages. It offers the possibility of large deformation measurement, while being much less sensitive to external perturbations. We ... [more ▼]

Holographic interferometry at around 10 µm wavelengths has many advantages. It offers the possibility of large deformation measurement, while being much less sensitive to external perturbations. We present the state-of-the art of this technique applied to several industrial cases of the space industry. In particular, we demonstrate that the technique is well adapted to measurement of full-field deformation maps of space structures undergoing large temperature variations typical to what they experience in space conditions. [less ▲]

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See detailPlanet formation imager: Project update
Monnier, J. D.; Ireland, M.; Kraus, S. et al

in Proceedings of SPIE : The International Society for Optical Engineering (2018, July 01), 10701

The Planet Formation Imager (PFI) is a near- and mid-infrared interferometer project with the driving science goal of imaging directly the key stages of planet formation, including the young proto-planets ... [more ▼]

The Planet Formation Imager (PFI) is a near- and mid-infrared interferometer project with the driving science goal of imaging directly the key stages of planet formation, including the young proto-planets themselves. Here, we will present an update on the work of the Science Working Group (SWG), including new simulations of dust structures during the assembly phase of planet formation and quantitative detection efficiencies for accreting and non-accreting young exoplanets as a function of mass and age. We use these results to motivate two reference PFI designs consisting of a) twelve 3m telescopes with a maximum baseline of 1.2km focused on young exoplanet imaging and b) twelve 8m telescopes optimized for a wider range of young exoplanets and protoplanetary disk imaging out to the 150K H2O ice line. Armed with 4 x 8m telescopes, the ESO/VLTI can already detect young exoplanets in principle and projects such as MATISSE, Hi-5 and Heimdallr are important PFI pathfinders to make this possible. We also discuss the state of technology development needed to make PFI more affordable, including progress towards new designs for inexpensive, small field-of-view, large aperture telescopes and prospects for Cubesat-based space interferometry. © 2018 SPIE. [less ▲]

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See detailExperimental performance of a field of parabolic trough collectors for small-scale power generation
Dickes, Rémi ULiege; Dumont, Olivier ULiege; Thiebaut, Jérémie et al

in Proceedins of ECOS 2018 (2018, June 23)

The present work investigates the solar field performance of a pilot system installed at the University of Liège in Belgium. The system includes eight parabolic trough collectors connected in series (66m² ... [more ▼]

The present work investigates the solar field performance of a pilot system installed at the University of Liège in Belgium. The system includes eight parabolic trough collectors connected in series (66m² in total) and is aimed for small-scale power generation (2kWe) at low-temperature operation (150°C max.). The paper describes the test facility and presents experimental data gathered under various operating conditions. After posttreatment, the measurements are used to calibrate a deterministic model of the solar collectors. This model is used to better estimate the various sources of losses during the solar energy conversion and to investigate potential means of performance improvements. While the collection efficiency recorded experimentally does not exceed 30%, it is shown that an improvement of the tracking could raise this value to 65% and thus meet the design expectations. [less ▲]

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See detailLaser ultrasound flexible system for non-contact inspection of medium size and complex shaped composite structures made of carbon fiber reinforced polymer
Vandenrijt, Jean-François ULiege; Languy, Fabian ULiege; Thizy, Cédric ULiege et al

in Proceedings (2018, June 22), 2018(2), 455

We present the development of a contactless laser ultrasound system for nondestructive inspection of CFRP complex structures. Ultrasound are generated by a thermoelastic effect resulting from a green ... [more ▼]

We present the development of a contactless laser ultrasound system for nondestructive inspection of CFRP complex structures. Ultrasound are generated by a thermoelastic effect resulting from a green pulsed laser insulating a point of the inspected part. The resulting displacement of the surface point is probed by a two-wave mixing based interferometer working in the near infrared. The system is flexible and completely fiber-coupled. It is able to provide C-scans on complex shaped CFRP aeronautical structures. [less ▲]

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See detailThermography and Shearography Inspection of Composite Hybrid Sandwich Structure Made of CFRP and GFRP Core and Titanium Skins
Georges, Marc ULiege; Srajbr, Christian; Menner, Philipp et al

in Proceedings (2018, June 22), 2018(2), 484

We have investigated several full-field contactless techniques, such as thermography and shearography, with several excitation methods for inspecting hybrid composite-metal sandwich structures. The latter ... [more ▼]

We have investigated several full-field contactless techniques, such as thermography and shearography, with several excitation methods for inspecting hybrid composite-metal sandwich structures. The latter are made of a core with epoxy reinforced by carbon and glass fibers and skins of titanium. Several calibrated defects are incorporated at different places in depth and are made of air gaps and inserts. [less ▲]

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See detailHYALURONAN DERIVATIVE HYMOVIS® INCREASES CARTILAGE VOLUME AND TYPE II COLLAGEN TURNOVER IN OSTEOARHRITIC KNEE: DATA FROM MOKHA STUDY
Henrotin, Yves ULiege; Bannuru, R; Malaise, Michel ULiege et al

in Annals of the Rheumatic Diseases (2018, June), 77(supplement 2), 1614

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See detailEFFICACY OF BIO-OPTIMISED CURCUMA EXTRACT (FLEXOFYTOL®) FOR PAINFUL KNEE OSTEOARTHRITIS: DATA FROM COPRA, A MULTICENTER RANDOMISED CONTROLLED STUDY
Henrotin, Yves ULiege; Malaise, Michel ULiege; Wittoek, R et al

in Annals of the Rheumatic Diseases (2018, June), 77(supplement 2), 790

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See detailEx-vivo vasorelaxation induced by polyphenol-rich extracts from plant, fruits and berries on porcine coronary artery rings
Ebabe Elle, Etienne ULiege; Defraigne, Jean-Olivier ULiege; Schini-Kerth, Valérie et al

in Free Radical Biology and Medicine (2018, June), 120

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See detailGLUCOSEPANE : A NEW BIOMARKER OF THE SEVERITY OF OSTEOARTHRITIS
Rabbani, N; Ahmed, U; Lambert, Cécile ULiege et al

in Annals of the Rheumatic Diseases (2018, June), 77(supplement 2), 181

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See detailTHE COLL2–1 PEPTIDE OF COLLAGEN TYPE II: A NEW ACTOR OF SYNOVITIS IN OSTEOARTHRITIS
Lambert, Cécile ULiege; Borderie, D; Rannou, F et al

in Annals of the Rheumatic Diseases (2018, June), 77(supplement 2), 890

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See detailProteomic analysis of osteoblasts secretome provides new insights in mechanisms underlying osteoarthritis subchondral bone sclerosis
Sanchez, Christelle ULiege; Mazzucchelli, Gabriel ULiege; Comblain, Fanny et al

in Annals of the Rheumatic Diseases (2018, June), 77(supplement 2), 894

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See detailPCI & Auditory ERPs for the diagnosis of disorders of consciousness: a EEG-based methods comparison study
Blandiaux, Séverine ULiege; Raimondo, Federico ULiege; Wolff, Audrey ULiege et al

in European Journal of Neurology (2018, June), 25(S2),

INTRODUCTION Diagnosing the level of consciousness in patients suffering from severe brain lesions is still a major challenge. EEG-based systems can help discriminate conscious from unconscious patients ... [more ▼]

INTRODUCTION Diagnosing the level of consciousness in patients suffering from severe brain lesions is still a major challenge. EEG-based systems can help discriminate conscious from unconscious patients. This study aims to confront the results from two of the most reliable methods: the Perturbational Complexity Index (PCI) which is based on Transcranial Magnetic Stimulation (TMS-EEG), and a recent machine learning approach using EEG-extracted markers from a standardized oddball auditory stimulation paradigm (EEG-ERP). METHODS Patients presenting either an unresponsive wakefulness syndrome (UWS), a minimally conscious state (MCS) or an emergence of MCS (EMCS) underwent both TMS-EEG and EEG-ERP. We computed PCI value by compressing the spatiotemporal pattern of cortical responses to the perturbation of the cortex with TMS. For EEG-ERP, we extracted 60 markers corresponding to quantification of power spectrum and complexity in individual EEG sensors and information sharing between them. Using machine-learning, we predicted the individual probability of being (minimally) conscious. RESULTS PCI and EEG markers, when considered categorically (i.e. UWS vs MCS), were consistent for all UWS and EMCS patients, whereas the results for MCS patients showed less consistency. Nevertheless, we found a significant correlation between PCI values and the probability of being conscious with the multivariate classifier. CONCLUSION PCI correlated positively with the combination of EEG markers in severely brain-injured patients. These findings imply that EEG signatures of consciousness can be reliably extracted from different contexts and combined into coherent predictive models, encouraging future efforts in large-scale data-driven clinical neuroscience. [less ▲]

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See detailA comparison of the P300 and PET in patients with disorders of consciousness in absence of response to command
Annen, Jitka ULiege; Wolff, Audrey ULiege; Blandiaux, Séverine ULiege et al

in European Journal of Neurology (2018, June), 25(S2),

Detection and interpretation of signs of "covert command following" in patients with disorders of consciousness (DOC) remains a challenge for clinicians. In this study, we used a tactile P3-based BCI in ... [more ▼]

Detection and interpretation of signs of "covert command following" in patients with disorders of consciousness (DOC) remains a challenge for clinicians. In this study, we used a tactile P3-based BCI in 12 patients without behavioral command following, attempting to establish "covert command following." These results were then confronted to cerebral metabolism preservation as measured with glucose PET (FDG-PET). One patient showed "covert command following" (i.e., above-threshold BCI performance) during the active tactile paradigm. This patient also showed a higher cerebral glucose metabolism within the language network (presumably required for command following) when compared with the other patients without "covert command-following" but having a cerebral glucose metabolism indicative of minimally conscious state. Our results suggest that the P3-based BCI might probe "covert command following" in patients without behavioral response to command and therefore could be a valuable addition in the clinical assessment of patients with DOC. [less ▲]

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See detailIn-flight characterization and calibration of the Juno-Ultraviolet Spectrograph (Juno-UVS)
Hue, V.; Kammer, J. D.; Gladstone, G. R. et al

in Proceedings of SPIE : The International Society for Optical Engineering (2018, June)

The Juno mission, orbiting Jupiter since July 2016, offers an unprecedented opportunity to study Jupiter, from its internal structure to its magnetospheric environment. Juno-UVS is a ultraviolet (UV ... [more ▼]

The Juno mission, orbiting Jupiter since July 2016, offers an unprecedented opportunity to study Jupiter, from its internal structure to its magnetospheric environment. Juno-UVS is a ultraviolet (UV) photon counting spectrograph with a bandpass of 68<λ<210 nm. The main purpose of Juno-UVS is to observe and characterize Jupiter’s UV auroral emissions and provide global context for Juno’s in-situ particles and fields instruments. Juno is a spinning spacecraft that nominally spins at 2 rpm, so it spends a significant amount of time observing the sky background, including stars, interplanetary medium and extragalactic sources. We present here how we use this information to: (i) characterize and calibrate Juno-UVS; and (ii) monitor the detector response over the mission. [less ▲]

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See detailTerahertz hyper-spectral imaging of lab-prepared versus commercial paracetamol tablets and potential applications
Nguyen, Thi Dinh; Dortu, Fabian; Dispas, Amandine ULiege et al

in Proceedings of SPIE : The International Society for Optical Engineering (2018, May 28), 1067731

Terahertz spectroscopy and imaging have proved to be a versatile tool for the studying of drugs and pharmaceutical analysis. Particularly, this method has been employed to map the coating layer of ... [more ▼]

Terahertz spectroscopy and imaging have proved to be a versatile tool for the studying of drugs and pharmaceutical analysis. Particularly, this method has been employed to map the coating layer of pharmaceutical tablets, to identify the polymorphism of active pharmaceutical ingredients (APIs), etc. In this paper, Terahertz (THz) hyper-spectral imaging using time-domain spectroscopy technique has been applied to image a commercial packaging of paracetamol tablets, showing the ability to penetrate through both cardboard of the box and plastic cover of the blister pack. The advantage of THz time-domain spectroscopy (THz-TDS) is that not only the dimensional imaging was captured but also the spectral information was registered. A comparison between THz spectrum of commercial and lab-prepared paracetamol tablets shows the presence of a certain amount of α-D-lactose monohydrate at the absorption peak of 0.53 THz. Any API or excipients can be detected if their fingerprints fall in the measureable range of the system. This work opens up a possibility of using THz-TDS to non-destructively control the quality of pharmaceutical products while they are still in their packaging. This potential capacity is important as for the identification of the APIs as well as changing of unwanted physical (and hence biological) properties during the shelf-life of the product. [less ▲]

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See detailGUT MICROBIOTA AND FAECAL LEVELS OF SHORT CHAIN FATTY ACIDS DIFFER UPON BLOOD PRESSURE LEVELS IN MAN
HUART, Justine ULiege; Leenders, Justine ULiege; Taminiau, Bernard ULiege et al

in Nephrology Dialysis Transplantation (2018, May 18), 33(Issue suppl_1), 368369

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See detailWeb Monitoring of Bee Health for Researchers and Beekeepers Based on the Internet of Things
Debauche, Olivier ULiege; El Moulat, Meryem; Mahmoudi, Saïd et al

in Procedia Computer Science (2018, April 24), 130

The Colony Collapse Disorder (CCD) also entitled ‘Colony Loss’ has a significant impact on the biodiversity, on the pollination of crops and on the profitability. The Internet of Things associated with ... [more ▼]

The Colony Collapse Disorder (CCD) also entitled ‘Colony Loss’ has a significant impact on the biodiversity, on the pollination of crops and on the profitability. The Internet of Things associated with cloud computing offers possibilities to collect and treat a wide range of data to monitor and follow the health status of the colon. The surveillance of the animals’ pollination by collecting data at large scale is an important issue in order to ensure their survival and pollination, which is mandatory for food production. Moreover, new network technologies like Low Power Wide Area (LPWAN) or 3GPP protocols and the appearance on the market easily programmable nodes allow to create, at low-cost, sensors and effectors for the Internet of Things. In this paper, we propose a technical solution easily replicable, based on accurate and affordable sensors and a cloud architecture to monitor and follow bees’ behavior. This solution provides a platform for researchers to better understand and measure the impacts factors which lead to the mass extinction of bees. The suggested model is also a digital and useful tool for beekeepers to better follow up with their beehives. It helps regularly inspect their hives to check the health of the colony. The massive collection of data opens new research for a better understanding of factors that influence the life of bees. [less ▲]

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See detailObservation and simulation of ethane (C2H6) at 23 FTIR sites
Mahieu, Emmanuel ULiege; Franco, B.; Pozzer, A. et al

in Geophysical Research Abstracts (2018, April 11), 20

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See detailAttempting to retrieve peroxyacetyl nitrate from ground-based infrared solar spectra
Mahieu, Emmanuel ULiege; Fischer, Emily V.; Tzompa-Sosa, Zitely A. et al

in Geophysical Research Abstracts (2018, April 09), 20

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See detailImpact of the frailty status on the cost of drugs consumed in nursing homes: results froim the Senior cohort.
Buckinx, Fanny ULiege; Charles, Alexia ULiege; Quabron, A. et al

in Osteoporosis International (2018, April 05), 29 S1

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See detailAgisme en maison de repos : résultats de la cohorte SENIOR
Buckinx, Fanny ULiege; Adam, Stéphane ULiege; Charles, Alexia ULiege et al

in Cahiers de l'Année Gérontologique (2018, April 05)

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See detailThe 4-m International Liquid Mirror Telescope
Surdej, Jean ULiege; Hickson, P.; Borra, H. et al

in Bulletin de la Société Royale des Sciences de Liège (2018, April 01), 87

The 4-m International Liquid Mirror Telescope (ILMT) is presently (March-June 2017) being erected on the ARIES site in Devasthal (Uttarakhand). We describe and illustrate in the present paper its ... [more ▼]

The 4-m International Liquid Mirror Telescope (ILMT) is presently (March-June 2017) being erected on the ARIES site in Devasthal (Uttarakhand). We describe and illustrate in the present paper its different components. The ILMT will be used in the Time Delayed Integration (TDI) mode to carry out a deep survey and high S/N photometric and astrometric observations of solar system, galactic and extra-galactic objects within a narrow (24') strip of sky. In principle, the ILMT should detect and regularly monitor more than 50 multiply imaged quasars. It will also detect numerous supernovae (see Kumar et al., these proceedings) as well as space debris (see Pradhan et al., also in these proceedings). [less ▲]

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See detailProceedings of the 1st BINA workshop: Instrumentation and Science with the 3.6-m DOT and 4-m ILMT telescopes
De Cat, P.; Surdej, Jean ULiege; Omar, A. et al

in Bulletin de la Société Royale des Sciences de Liège (2018, April 01), 87

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See detailThe multi-messenger approach to particle acceleration by massive stars: a science case for optical, radio and X-ray observatories
De Becker, Michaël ULiege

in Bulletin de la Société Royale des Sciences de Liège (2018, April 01), 87

Massive stars are extreme stellar objects whose properties allow for the study of some interesting physical processes, including particle acceleration up to relativistic velocities. In particular, the ... [more ▼]

Massive stars are extreme stellar objects whose properties allow for the study of some interesting physical processes, including particle acceleration up to relativistic velocities. In particular, the collisions of massive star winds in binary systems lead notably to acceleration of electrons involved in synchrotron emission, hence their identification as non-thermal radio emitters. This has been demonstrated for about 40 objects so far. The relativistic electrons are also expected to produce non-thermal high-energy radiation through inverse Compton scattering. This class of objects permits thus to investigate non-thermal physics through observations in the radio and high energy spectral domains. However, the binary nature of these sources introduces some stringent requirements to adequately interpret their behavior and model non-thermal processes. In particular, these objects are well-established variable stellar sources on the orbital time-scale. The stellar and orbital parameters need to be determined, and this is notably achieved through studies in the optical domain. The combination of observations in the visible domain (including e.g. 3.6-m DOT) with radio measurements using notably GMRT and X-ray observations constitutes thus a promising strategy to investigate particle-accelerating colliding-wind binaries in the forthcoming decade. [less ▲]

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See detailCHRONIC TENDINOPATHIES AND PLATELET-RICH PLASMA TREATMENT: HOW TO IMPROVE THE EFFICIENCY?
Kaux, Jean-François ULiege; Emonds-Alt, Thibault ULiege

in Osteoporosis International (2018, April), 29(Supplement 1), 380-381

Introduction: Platelet-rich plasma (PRP) is blood plasma with a high concentration of autologous platelets which constitute an immense reservoir of growth factors. The clinical use of PRP is widespread in ... [more ▼]

Introduction: Platelet-rich plasma (PRP) is blood plasma with a high concentration of autologous platelets which constitute an immense reservoir of growth factors. The clinical use of PRP is widespread in various medical applications. Although highly popular with athletes, the use of PRP for the treatment of tendinopathies remains scientifically controversial, particularly due to the diversity of products that go by the name of “PRP”. This may partly explain the disparity of results obtained in the literature. Purpose: The objective of this study was to evaluate the similarities and differences between the variety of PRP formulations, preparation, and uses of this techniques in literature and to try to determine characteristics of the PRP which tend to give the best responses for the treatment of knee osteoarthritis. Methods: In a literature review, we take a closer look at eight parameters which may influence the quality of PRP: 1) anticoagulants used to preserve the best platelet function, 2) the speed of centrifugation used to extract the platelets, 3) the platelet concentrations obtained, 4) the impact of the concentration of red and while blood cells on PRP actions, 5) platelet activators encouraging platelet degranulation and, hence, the release of growth factors, and 6) the use or nonuse of local anesthetics when carrying out infiltration. In addition to these parameters, it may be interesting to analyze other variables such as 7) the use of ultrasound guidance during the injection with a view to determining the influence they have on potential recovery. Results: Analysis of the 59 studies shows that a majority use ACDA as an anticoagulant during sampling. A platelet activator (calcium chloride) is only used in a few studies. However, the best results have been obtained in studies which use no platelet activator. In terms of the speed of centrifugation, analysis of all these studies appears to confirm the existence of a great number of protocols in the literature. It is difficult to draw any conclusions when these different variables are unknown (volume of initial sample, equipment used to obtain the PRP). Currently, no studies have been carried out neither on the use of a “buffer” product to neutralize the acidity caused by the anticoagulant nor on the optimal volume of PRP to be injected. Although it would appear inadvisable to administer a local anesthetic because the anesthetic may reduce the local pH and lead to the inhibition, reduction, or absence of platelet degranulation, the literature shows that the majority use a local anesthetic. They do not, however, obtain better results than those not using a local anesthetic. Finally, it appears to be advisable to carry out infiltration under ultrasound guidance, even if PRP diffusion is observed after injection. This all aims to show that there is still a need for high quality studies, with standardized collection protocols and the use of PRP in the context of tendinopathies, in order to better scientifically understand the real effectiveness. Conclusion: There is a lack of standardization in PRP preparation technique for chronic tendinopathies. However, our study helped identify features of PRP recommended a platelet concentration lower than 5 times the baseline (from 3 to 4), and avoiding leukocytes and erythrocytes. We recommend leveraging this information about PRP for future studies. [less ▲]

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See detailKNEE OSTEOARTHRITIS AND PLATELET-RICH PLASMA TREATMENT: HOW TO IMPROVE THE EFFICIENCY?
MILANTS, Christophe ULiege; Bruyère, Olivier ULiege; Kaux, Jean-François ULiege

in Osteoporosis International (2018, April), 29(Supplement 1), 380

Introduction: Knee osteoarthritis (OA) is one of the major causes of pain and physical disability in older sportsmen. The management of chondral disease is challenging because of its inherent low healing ... [more ▼]

Introduction: Knee osteoarthritis (OA) is one of the major causes of pain and physical disability in older sportsmen. The management of chondral disease is challenging because of its inherent low healing potential. New studies have focused on modern therapeutic methods that stimulate cartilage healing process and improve the damage, including the use of platelet-rich plasma (PRP), an autologous growth factor treatment. PRP is prepared from autologous blood by centrifugation to obtain a highly concentrated sample of platelets, which is four to five times higher than that of normal blood. Many papers were published on PRP for knee OA, including a lot of randomized controlled trials (RCTs) and different systematic reviews. Due to the mixed results from controlled studies, the clinical efficacy of PRP in the treatment of knee OA is unclear with shortcomings in the current literature. Purpose: The objective of this study was to evaluate the similarities and differences between the variety of PRP formulations, preparation, and uses of this techniques in literature and to try to determine characteristics of the PRP which tend to give the best responses for the treatment of knee osteoarthritis.. Methods: A comparison of the outcomes of randomized controlled trials (RCTs) included in the 3 most recent and high-quality metaanalyses to classify the different studies in 2 groups (bad responders group (BRG) and very good responders group (VGRG)). The minimal clinically important improvement (MCII) was defined to help determining whether an observed difference is clinically important. We used MCII values to classify the different studies in 2 groups depending on the outcomes: BRG < MCII and VGRG > 2xMCII. Results: From the 19 RCTs analyzed, 7 trials were included in the VGRG and 4 in the BRG. In VGRG, 1 or 2 injections were performed in 4/7 trials, time between injections was 2 to 3 weeks in 4/5 studies with many injections, volume injected varied from 2.5 to 8 mL, and single spinning technique was used in 5/7 studies. PRP classification was Mishra 4B and PAWP2Bβ in 5/7 studies. The use of PRP with leukocytes is only found in the BRG. Conclusion: There is a lack of standardization in PRP preparation technique for knee osteoarthritis. However, our study helped identify features of PRP recommended for knee OA treatment, such as the use of a single spinning technique, a platelet concentration lower than 5 times the baseline (from 3 to 4), and avoiding leukocytes and erythrocytes. We recommend leveraging this information about PRP for future studies. [less ▲]

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See detailOwn attitude regarding aging among nursing home residents: results of the Senior cohort.
Buckinx, Fanny ULiege; Charles, Alexia ULiege; Rygaert, X. et al

in Osteoporosis International (2018, April), 29 S1

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See detailThe polish validation of the Sarquol®, a quality of life questionnaire specific for sarcopenia: the evidence of a good utility.
Konstantynowicz, J.; Abramowicz, P.; Glinkowski, W. et al

in Osteoporosis International (2018, April), 29 S1

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See detailStatins and incident knee osteoarthritis: results from the osteoarthritis initiative.
Veronese, N.; Maggi, S.; Cooper, C. et al

in Osteoporosis International (2018, April), 29 S1

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See detailDeterminants of clinical and radiological progression of hand osteoarthritis over 2 years.
Neuprez, Audrey ULiege; Neuprez, Arnaud ULiege; Maheu, E. et al

in Osteoporosis International (2018, April), 29 S1

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See detailAbaloparatide for risk reduction of non-vertebral fractures in postmenopausal women with osteoporosis: an updated network meta-analysis.
Reginster, Jean-Yves ULiege; Bianic, F.; Campbell, R. et al

in Osteoporosis International (2018, April), 29 S1

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See detailCost-effectiveness of abaloparatide for the treatment of postmenopausal women with osteoporosis.
Hiligsmann, M.; Williams, S.A.; Fitzpatrick, L.A. et al

in Osteoporosis International (2018, April), 29 S1

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See detailAssociation between dietary nutrient intake and sarcopenia: the SarcoPhAge cohort study.
Beaudart, Charlotte ULiege; Locquet, Médéa ULiege; Touvier, M. et al

in Osteoporosis International (2018, April), 29 S1

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See detailDynamic approach of the frailty status in nursing homes: 2-year prospective follow-up of the Senior cohort.
Buckinx, Fanny ULiege; Charles, Alexia ULiege; Rygaert, X. et al

in Osteoporosis International (2018, April), 29 S1

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See detailSafety of anti-osteoarthtritis medications: results of ESCEO 2017 working groups.
Reginster, Jean-Yves ULiege

in Osteoporosis International (2018, April), 29 S1

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See detailPro-inflammatory dietary pattern is associated with fractures in women: an eight year longitudinal cohort study.
Veronese, N.; Shivappa, N.; Hebert, J. et al

in Osteoporosis International (2018, April), 29 S1

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See detailDairy products in the prevention and treatment of sarcopenia: outcomes of the ESCEO working groups.
Reginster, Jean-Yves ULiege

in Osteoporosis International (2018, April), 29 S1

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See detailA new decision tree for diagnosis and management of osteoarthritis in primary care: international consensus of experts.
Rannou, F.; Martel-Pelletier, J.; Pelletier, J. et al

in Osteoporosis International (2018, April), 29 S1

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See detailA 24 months prospective, randomized, double-blind study to assess the effect of daily oral administration of 2g of strontium ranelate vs placebp on BMD in postmenpausal.
Felsenberg, D.; Chapurlat, R.; Rizzoli, R et al

in Osteoporosis International (2018, April), 29 S1

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See detailReview of terminology of measurement properties for patient-reported outcomes measures.
Rabenda, Véronique ULiege; Leclercq, Victoria ULiege; Reginster, Jean-Yves ULiege et al

in Osteoporosis International (2018, April), 29 S1

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See detailEE joint replacement in patients with knee osteoarthritis: a long tem follow-up study in patients of the CL3-12911-018 study.
Cooper, C.; Reginster, Jean-Yves ULiege; Belissa-Mathiot, P.

in Osteoporosis International (2018, April), 29 S1

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See detailPatient’s engagement in the identification of critical outcomes in sarcopenia.
Beaudart, Charlotte ULiege; Bruyère, Olivier ULiege; Reginster, Jean-Yves ULiege et al

in Osteoporosis International (2018, April), 29 S1

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See detailCost-effectiveness of sequential treatment with abaloparatide vs. teriparatide for the prevention of osteoporotic fractures in postmenopausal women at increased risk of fracture.
Hiligsmann, M.; Williams, S.A.; Fitzpatrick, L.A. et al

in Osteoporosis International (2018, April), 29 S1

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See detailReassessment of the safety of anti-osteoarthritis medications.
Bruyère, Olivier ULiege; Curtis, E.; Honvo, Germain ULiege et al

in Osteoporosis International (2018, April), 29 S1

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See detailAGN1 local osteo-enhancement procedure (LOEP): an emerging, minimally-invasive surgical treatment to address osteoporosis-related bone loss in proximal femurs.
Ferrari, S.; McCloskey, E.; Bouxsein, M. et al

in Osteoporosis International (2018, April), 29 S1

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See detailDoes urban flood resilience compete with sustainable urban planning as a whole?
Bruwier, Martin ULiege; Mustafa, Ahmed Mohamed El Saeid ULiege; Archambeau, Pierre ULiege et al

in Geophysical Research Abstracts (2018, April), 20

Sustainable urban planning aims at designing the urban fabric so that it meets the needs of an expanding urban population, while synergistically addressing a number of environmental objectives such as ... [more ▼]

Sustainable urban planning aims at designing the urban fabric so that it meets the needs of an expanding urban population, while synergistically addressing a number of environmental objectives such as transport, energy and resource efficiency. Urban densification is a key concept in sustainable urban planning, as it contributes to reduce pressure on environmentally sensitive lands and it makes several services more efficient, including water and energy supply. Similarly, at a local level, intervening spaces in-between buildings should be minimized to enhance heating efficiency. In this communication, we will report on two recent studies focusing on urban flood resilience. Both of them suggest that flood-resilient urban design tends to conflict with the two aforementioned aspects of sustainable urban development. The first study was conducted at the regional level, covering the whole Walloon Region in Belgium (17,000 km2). First, an original agent-based model was used to generate multiple urbanization scenarios with contrasting assumptions on spatial planning policies: urban expansion (sprawl) vs. urban densification, various degrees of ban on new developments in flood-prone areas . . . Next, flood damage modelling was performed along over 1,300 km of river. The results show that the urban densification scenarios lead to systematically higher flood risk estimates, since they promote new developments in the vicinity of existing urban areas mainly located in the lower parts of the river valleys. In a second study, conducted at the district level, we investigated how inundation severity is affected by the arrangement of buildings in floodplains . A set of 2,000 building layouts were synthetized using procedural modelling (Bruwier et al., 2018). Each building layout is characterized by a set of parameters such as the typical street widths, building size . . . Next, the flow characteristics (water depth, flow velocity) were computed for each building layout considering the same flooding scenario. An original porosity-based model was set up for this purpose (Bruwier et al., 2017). The findings of the study reveal that increasing the separation space in-between buildings tends to improve flood-resilience at the district level, thanks to an increased flow conveyance across the urban area. At first sight, the conclusions inferred from the two studies focusing on flood-resilience only (higher future flood risk due to urban densification, benefit of keeping intervening space in-between buildings) seem to diverge from general good-practice in sustainable urban planning. We intend to use this provocative statement to foster discussion with the audience on issues such as: “How can more integrated approaches mitigate such apparent contradictions?”, “How to best modulate sustainable urban planning principles to accommodate urban flood resilience?” [less ▲]

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See detailEvaluation of the responsiveness of the SARQOL® questionnaire: results from the SarcoPhAge study.
GEERINCK, Anton ULiege; Bruyère, Olivier ULiege; Locquet, Médéa ULiege et al

in Osteoporosis International (2018, April), 29 S1

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See detailGuidelines for the conduct of pharmacological clinical trials in hand osteoarthritis: consensus of a working group of the ESCEO
Reginster, Jean-Yves ULiege; Arden, NK; Haugen, IK et al

in Osteoporosis International (2018, April), 29(Suppl1), 71-2

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See detailCost-effectiveness evaluation of glucosamine in osteoarthritis based on simulation of data coming from published studies
Bruyère, Olivier ULiege

in Osteoporosis International (2018, April), 29(Suppl1), 554-5

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See detailThe discriminative ability of SARQOL according to the definition of sarcopenia: The OFELY study
Sornay-Rendu, E; Beaudart, Charlotte ULiege; Bruyère, Olivier ULiege et al

in Osteoporosis International (2018, April), 29(Suppl1), 61

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See detailVitamin D and muscle function
Bruyère, Olivier ULiege

in Osteoporosis International (2018, April), 29(Suppl1), 124

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See detailSarcopenia and quality of life questionnaire (SARQOL): Greek cross cultural adaptation
Tsekoura, M; Billis, E; Gliatis, J et al

in Osteoporosis International (2018, April), 29(Suppl1), 93

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See detailMuscle Function assessment in daily practice
Bruyère, Olivier ULiege; Beaudart, Charlotte ULiege

in Osteoporosis International (2018, April), 29(Suppl1), 87

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See detailA Prospective Audit of Acute ENT Activity in a Teaching Hospital.
Goffinet, Maxime ULiege; ATTA, Lucas; Delrez, Sophie ULiege et al

in B-ENT (2018, March 03)

Introduction and aim: Acute ENT coverage is available out-of-hours in most hospitals. However, increasing pressure to reduce healthcare cost threatens this service provision round the clock. Our goal was ... [more ▼]

Introduction and aim: Acute ENT coverage is available out-of-hours in most hospitals. However, increasing pressure to reduce healthcare cost threatens this service provision round the clock. Our goal was to audit the emergency ENT activity in our institution over a one-month period Material and methods: a prospective audit for all ENT referrals from the emergency department was carried out from May 1st to May 31th 2017. Descriptive statistics were produced for age, sex, origin, time of arrival, diagnosis and patient outcome. Results: a total of 190 patients (109 men and 81 women) were referred to the ENT emergency service over the study period (mean 6.1 case per day). Mean age was 47.9 (±23.6)year (range 1-95). Most patients were ambulatory (75.8%) and came from the area. Most admissions occurred during normal working hours (76.4%) and 62.0% patients came by self reference. The mean complaint duration before admission was 7.6 (±13.7) days (range 0-92 days). One third (33.2% patients) required ambulatory treatment. A quarter (24.7% patients) underwent a minor ENT procedure. Eighteen (9.5%) patients required admission to the ward (mostly for intravenous antibiotic). Eight patients (4.2%) required surgical treatment. There was no difference in the severity of diagnosis or management between patients referred by a physician (GP of specialist) and patients presenting spontaneously. At 30 days, 3 (1.6%) patients died (one of ENT cancer, two of unrelated cause), 106 (55.8%) benefited from an ENT follow’up, 65 (34.2%) were referred to another physician (GP or specialist), 16 (8.4%) were lost to follow’up. Conclusions: The workload suggests that emergency ENT activity is justified in our hospital. Restricting emergency ENT cover to patients referred by a GP or another physician would not allow for a better patient selection. [less ▲]

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See detailLight-harvesting capabilities of dielectric sphere multilayers
Baron, Damien ULiege; Dewalque, Jennifer ULiege; Henrist, Catherine ULiege et al

in Proceedings of SPIE : The International Society for Optical Engineering (2018, March), 10541

Self-assembled synthetic opals are suitable for integration into solution-processed thin film solar cells. In this work, finite-difference time-domain simulations are carried out to tailor optical ... [more ▼]

Self-assembled synthetic opals are suitable for integration into solution-processed thin film solar cells. In this work, finite-difference time-domain simulations are carried out to tailor optical properties of monolayer and multilayers of semiconductor spheres to trap light when these structures are incorporated into thin film solar cells. In particular, architectures in which spheres are filled with a photoactive material and embedded in a lower refractive index medium are examined. Based on spectra and field intensity maps, this study demonstrates that opal-like photonic crystals obtained from colloidal templates and filled with light-absorbing material can significantly harvest light by exploiting photonic band resonances. [less ▲]

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See detailPost-irradiated Carotid Blowout Syndrome in patients with Nasopharyngeal Tumor: about 3 cases
DETROUX, Valentine ULiege; GOFFART, Yves; COLLIGNON, Laurent et al

in B-ENT (2018, March)

Introduction Rupture of the internal carotid artery (Carotid blowout syndrome) is a rare complication of irradiated nasopharyngeal tumor. We report three cases nasopharyngeal tumors treated with ... [more ▼]

Introduction Rupture of the internal carotid artery (Carotid blowout syndrome) is a rare complication of irradiated nasopharyngeal tumor. We report three cases nasopharyngeal tumors treated with radiotherapy complicated with bleeding of the internal carotid artery presenting as a massive epistaxis. Case Series The first case presented a few episodes of small nose bleeding before a massive one. Internal carotid embolisation was performed to stop the bleeding. Unfortunately, few month later, he presented a meningitis related to skull base osteoradionecrosis and died from sceptic shock. The second case was transferred to our hospital with severe repetitive epistaxis that had been occurring for hours. No endovascular treatment was possible in his case and he died in intensive care unitthe dayof his admission. The thrid case presented one massive epistaxis which stopped without any treatment or compression. A spontaneous occlusion of his internal carotid artery occured without any neurological defects. He recently benefited from a nasopharyngeal muscle flap for the coverage of the carotid artery. These three patients all presented with a history of nasopharyngeal tumor handled by radiotherapy. Pathogenesis, treatment, and outcome are discussed on the light of a comprehensive literature review. Conclusions Carotid blowout syndrome secondary to radiation therapy is rare but life-threatening. Re-irradiation and skull base osteoradionecrosis are strong predisposing factors. [less ▲]

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See detailComparaison entre infiltrations de plasma riche en plaquettes et d’acide hyaluronique pour le traitement des tendinopathies patellaires
Kaux, Jean-François ULiege; Roberjot, Mathieu; Samson, Antoine

in Journal de Traumatologie du Sport (2018, March), 35(1), 63

Introduction : Le traitement des tendinopathies patellaires reste difficile. C’est la raison pour laquelle de nouveaux traitements ont été développés, parmi lesquels les injections de plasma riche en ... [more ▼]

Introduction : Le traitement des tendinopathies patellaires reste difficile. C’est la raison pour laquelle de nouveaux traitements ont été développés, parmi lesquels les injections de plasma riche en plaquettes (PRP) ou d’acide hyaluronique (AH). Certaines séries cliniques ont précédemment évalué l’effet du PRP dans le traitement des tendinopathies patellaires proximales. Une revue systématique récente a conclu que les PRP pouvait être recommandé comme traitement dans cette indication. Récemment, l’AH en injection a été proposé comme traitement des tendinopathies. Certaines études fondamentales montrent des résultats encourageants sur la capacité de l’AH à promouvoir le glissement du tendon, de réduire les adhérences et améliorer son organisation architecturale. Quelques observations cliniques confirment également son impact sur la douleur et la fonction de patients avec tendinopathies. Méthodes : Trente-trois sportifs avec tendinopathies patellaires proximales non soulagés après plus de trois mois de traitements rééducatif classique ont été inclus dans l’étude. Dix-huit d'entre eux (groupe 1) ont reçu une injection de PRP pauvre en leucocytes (obtenu à l’aide d’un appareil d’aphérèse) et 15 autres sujets (groupe 2) ont bénéficié de 2 injections d’AH à 1 semaine d’intervalle; les 2 groupes ont bénéficié d’une rééducation standardisée post-infiltration. Concernant le suivi de la pathologie, une évaluation de la douleur par une échelle visuelle analogique (EVA), des scores algo-fonctionnels (IKDC, VISA-P), un algomètre de pression, un test isocinétique (associé à une EVA)) ainsi qu’une échographie du tendon patellaire (US) ont été réalisés à 3 reprises (avant injection, après 6 semaines, 3 mois après les injections). Résultats : Les résultats de l’EVA (p < 0,01), de l’algomètre de pression (p < 0,01), les scores IKDC (p < 0,01) et VISA-P (p < 0,01) montrent une amélioration significative dans les deux groupes, mais pas pour les résultats US. Pour le groupe 1, les tests isocinétiques montrent des résultats significatifs pour les ischio-jambiers à C60 °/ s, avec une amélioration de son couple de pointe maximale (p = 0, 01) pour le membre pathologique et une amélioration des différences bilatérales (p = 0,0002). Pour le groupe 2, l’amélioration du couple de pointe maximale du quadriceps à C240 ° /s est significative (p < 0,01) pour le genou pathologique après les injections après 6 semaines seulement. L’EVA associé aux tests isocinétiques diminue considérablement pour tous les modes de contraction au terme des trois mois d’études. Conclusions : Les infiltrations de PRP et d’HA peuvent toutes les 2 améliorer les symptômes de tendinopathie patellaire proximale, même si les résultats sont légèrement meilleurs au sein du groupe PRP. [less ▲]

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