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See detailCross-cultural adaptation, translation, and validation of the functional assessment scale for acute hamstring injuries (FASH) questionnaire for French-speaking patients
Locquet, Médéa ULiege; Willems, Tom; Specque, Clément et al

in Disability and Rehabilitation (in press)

Study design: This consisted of a translation and validation study. Background: Acute hamstring injury is a frequent muscle strain in sports that require high explosive strength, impulsion or running ... [more ▼]

Study design: This consisted of a translation and validation study. Background: Acute hamstring injury is a frequent muscle strain in sports that require high explosive strength, impulsion or running phases. Therefore, the Functional Assessment Scale for Hamstring Injury questionnaire was developed to assess pain, physical activity level and ability to perform various exercises in patients with hamstring injuries. The Functional Assessment Scale for Hamstring Injury questionnaire is currently available in English, German, and Greek. Objectives: The goal of this study was to provide a cross-culturally adapted French-translation of the FASH questionnaire and to assess its psychometric performance. Methods: The French-translation and cross-cultural adaptation process were based on international recommendations, following six rigorous steps: (a) two initial translations from English to French; (b) synthesis of the two translations; (c) back-translations; (d) comparisons between the back-translations and the original questionnaire by an expert committee; (e) pretest; and (f) approval of the final French version of the Functional Assessment Scale for Hamstring Injury questionnaire. To validate this French version, 116 subjects (17 pathological patients, 19 patients with other muscle injury, 40 athletes at risk, and 40 healthy control athletes) were recruited to complete the Functional Assessment Scale for Hamstring Injury questionnaire. The Short Form Health Survey (SF-36) was used as a comparative questionnaire. The psychometric properties of the questionnaire were evaluated by determining the test-retest reliability after a 48–60-h interval, internal consistency, construct validity, and floor/ceiling effects. Results: All of the items of the Functional Assessment Scale for Hamstring Injury questionnaire were translated without any major difficulties. The questionnaire showed excellent discriminative power by obtaining significantly different scores from the four groups (p¼0.01). Regarding psychometric performances, the test–retest reliability was excellent (IntraClass Coefficient Correlation of 0.997). Very high internal consistency was also observed (Cronbach’s alpha of 0.969). Correlations with the physical health subscales of the SF-36 were significant and considered to be strong, indicating an excellent convergent validity. The other subscales of the SF-36 (mental health) were weakly correlated with the FASH, reflecting good divergent validity. No floor or ceiling effects were observed. Conclusion: The French-translation of the Functional Assessment Scale for Hamstring Injury questionnaire and its cross-cultural adaptation can be considered to be successful. Functional Assessment Scale for Hamstring Injury-French questionnaire is now a reliable and valid tool for patients suffering from acute hamstring injury, and its application in clinical practice is particularly relevant. IMPLICATIONS FOR REHABILITATION The FASH-F can be considered to be discriminant, reliable and valid for the evaluation of the severity of symptoms and sports ability in individuals with hamstring injuries. FASH-F is now a reliable and valid tool for French-speaking patients suffering from acute hamstring injury, and its application in clinical practice is particularly relevant. A limitation of our study could be that the distribution between the different study groups was not homogeneous implying that our findings may not be fully representative of the general population. [less ▲]

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See detailEuropean experience and risk factor analysis of donor cell-derived leukaemias/MDS following haematopoietic cell transplantation.
Engel, Nicole; Rovo, Alicia; Badoglio, Manuela et al

in Leukemia (in press)

Donor cell leukaemia (DCL) is a rare complication of allogeneic haematopoietic cell transplantation (HCT). We have investigated the prevalence and outcome of donor cell haematology malignancies within ... [more ▼]

Donor cell leukaemia (DCL) is a rare complication of allogeneic haematopoietic cell transplantation (HCT). We have investigated the prevalence and outcome of donor cell haematology malignancies within centres registered with the European Society of Blood and Marrow transplantation (EBMT). We have sought to identify risk factors to shed light on the pathogenesis of DCL as a model for leukaemogenesis. DCL cases were identified by questionnaire and a follow-up questionnaire requested detailed data. Control subjects from the EBMT registry who had not developed DCL were used for a matched pair analysis to identify risk factors. We identified 38 patients with DCL; the estimated prevalence was 80.5/100,000 transplants. Patients were predominantly treated for haematological malignancy. A clone was retrospectively identified in 7/25 (28%) donors for whom data was available. Overall survival was poor with 29/38 patients dead a median of 11 (range 0-91) months after DCL diagnosis. Matched case-pair analysis identified three factors on multivariate analysis as significantly associated with an increased risk for DCL: use of growth factors within the first 100 days after transplantation, in vivo T-cell depletion and multiple allografts. The risk factors identified, support reduced immune surveillance and replicative stress as pathogenic in the development of DCL. [less ▲]

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See detailEquivalence des hypothèses et relativité du mouvement dans la Dynamica
Bouquiaux, Laurence ULiege

in Studia Leibnitiana (in press)

Leibniz’s conception of the relativity of motion has been discussed at length for a very long time. This paper doesn’t aim to give a full solution to this question, but to contribute to the debate by ... [more ▼]

Leibniz’s conception of the relativity of motion has been discussed at length for a very long time. This paper doesn’t aim to give a full solution to this question, but to contribute to the debate by clarifying how the principle of relativity is introduced, justified and used in the Dynamica. Four different principles are identified : one purely geometrical, and three (meta)physical principles, which express God’s wisdom : a principle of equivalence of hypotheses linked to the action/reaction principle, a galilean principle of relativity and a general principle which apply not only to rectilinear motions but also to circular ones. I argue that to appreciate the coherence of Leibniz’ approach, we should distinguish these principles more sharply than he himself did and pay more attention to their status : are they consequences of the definition of motion, consequences of the physical laws or necessary conditions for any physical theory ? [less ▲]

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See detailL’Église des Piémontais à Rome au début du XVIIe siècle. Les “musiques extraordinaires” d’une nation composite
Morales, Jorge ULiege

in Revue Belge de Musicologie (in press), 73

Cet article présente les premiers résultats des recherches archivistiques sur la vie musicale de l’Église nationale des Piémontais à Rome. La construction de cette église va de pair avec la construction ... [more ▼]

Cet article présente les premiers résultats des recherches archivistiques sur la vie musicale de l’Église nationale des Piémontais à Rome. La construction de cette église va de pair avec la construction de l’identité et l’affirmation politique d’un duché qui, de « territoire tampon, devient un État intermédiaire » . Cette contribution permet d’examiner les transferts de sacralité qui s’opèrent entre le duché de Piémont-Savoie et la Ville éternelle, la manière dont cette église devient le théâtre de l’affirmation politique et sociale de la famille de Savoie, mais également la circulation des musiciens locaux et venus d’ailleurs qui font de l’église de la nation piémontaise un laboratoire de l’identité savoyarde à Rome. [less ▲]

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See detailNeurochemical models of near-death experiences: a large-scale study based on the semantic similarity of written reports
Martial, Charlotte ULiege; Cassol, Helena ULiege; Charland-Verville, Vanessa ULiege et al

in Consciousness and Cognition (in press)

The real or perceived proximity to death often results in a non-ordinary state of consciousness characterized by phenomenological features such as the perception of leaving the body boundaries, feelings ... [more ▼]

The real or perceived proximity to death often results in a non-ordinary state of consciousness characterized by phenomenological features such as the perception of leaving the body boundaries, feelings of peace, bliss and timelessness, life review, the sensation of traveling through a tunnel and an irreversible threshold. Near-death experiences (NDEs) are comparable among individuals of different cultures, suggesting an underlying neurobiological mechanism. Anecdotal accounts of the similarity between NDEs and certain drug-induced altered states of consciousness prompted us to perform a large-scale comparative analysis of these experiences. After assessing the semantic similarity between ≈15,000 reports linked to the use of 165 psychoactive substances with 625 NDE narratives, we determined that the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine consistently resulted in reports most similar to those associated with NDEs. Ketamine was followed by Salvia divinorum (a plant containing a potent and selective κ receptor agonist) and a series of serotonergic psychedelics, including the endogenous serotonin 2A receptor agonist N,N Dimethyltryptamine (DMT). This similarity was driven by semantic concepts related to consciousness of the self and the environment, but also by those associated with the therapeutic, ceremonial and religious aspects of drug use. Our analysis sheds light on the long-standing link between certain drugs and the experience of “dying“, suggests that ketamine could be used as a safe and reversible experimental model for NDE phenomenology, and supports the speculation that endogenous NMDA antagonists with neuroprotective properties may be released in the proximity of death. [less ▲]

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See detailPaclitaxel-loaded multifunctional nanoparticles for the targeted treatment of glioblastoma
Ganipineni, Lakshmi Pallavi; Ucakar, Bernard; Joudiou, Nicolas et al

in Journal of Drug Targeting (in press)

We hypothesized that the active targeting of αvβ3 integrin overexpressed in neoangiogenic blood vessels and glioblastoma (GBM) cells combined with magnetic targeting of paclitaxel- and SPIO-loaded PLGA ... [more ▼]

We hypothesized that the active targeting of αvβ3 integrin overexpressed in neoangiogenic blood vessels and glioblastoma (GBM) cells combined with magnetic targeting of paclitaxel- and SPIO-loaded PLGA-based nanoparticles could improve accumulation of nanoparticles in the tumor and therefore improve the treatment of GBM. Methods: PTX/SPIO PLGA nanoparticles with or without RGD-grafting were characterized. Their in vitro cellular uptake and cytotoxicity was evaluated by fluorospectroscopy and MTT assay. In vivo safety and anti-tumor efficacy of different targeting strategies was evaluated in orthotopic U87MG tumor model over multiple intravenous injections. Results: The nanoparticles of 250nm were negatively charged. RGD targeted nanoparticles showed a specific and higher cellular uptake than untargeted nanoparticles by activated U87MG and HUVEC cells. In vitro IC50 of PTX after 48h was approximately 1 ng/mL for all the PTX-loaded nanoparticles. The median survival time of the mice treated with magnetic targeted nanoparticles was higher than the control (saline) mice or mice treated with other evaluated strategies. The 6 doses of PTX did not induce any detectable toxic effects on liver, kidney and heart when compared to Taxol. Conclusion. The magnetic targeting strategy resulted in better therapeutic effect than the other targeting strategies (passive, active). [less ▲]

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See detailUnder which humidity conditions are moss spore released? A comparison between species with perfect and specialized peristomes
Zanatta, F.; Vanderpoorten, Alain ULiege; Hedenäs, L. et al

in Ecology and Evolution (in press)

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See detailEtude préliminaire de l’effet de l’activation comportementale sur les biais attentionnels envers l’information émotionnelle à valence positive et négative
Krings, Audrey ULiege; Wagener, Aurélie ULiege; Heeren, Alexandre et al

in Annales Médico-Psychologiques (in press)

Objectives: Behavioural activation improves mental health and psychological functioning, especially among patients with depression. Behavioural activation is associated with the improvement of several ... [more ▼]

Objectives: Behavioural activation improves mental health and psychological functioning, especially among patients with depression. Behavioural activation is associated with the improvement of several mechanisms, such as activation, avoidance, and environmental reward. Behavioural activation may also improve cognitive control abilities. Finally, studies on neurological changes suggested an improvement of the functioning of reward structures in response to positive stimuli after a BA treatment. Yet, uncertainty abounds regarding the putative mechanisms of behavioural activation. Prominent cognitive models of depression posit that attentional bias for negative and positive information may play an important role in the maintenance of a depressive mood. Inspired by these models and the results by the mentioned above, we investigated the impact of behavioural activation treatment for depression on attentional selectivity for sad and positive materials. We predicted that (1) attention to sad faces would be reduced after the intervention, (2) attention to happy faces would be enhanced after the intervention, and finally (3) the intervention would improve depressive symptomatology, activation, avoidance and environmental reward. Materials and method: Eight undergraduate students with medium to moderate depressive symptoms participated in a six-week behavioural activation intervention. A dot-probe task with happy and sad faces and self-report questionnaires focused on depression, activation, avoidance, and environmental reward were administered before and after the intervention. Results: Depression, avoidance, and environmental reward scores improved after treatment with large effect sizes. Behavioural activation likewise improves attentional bias for positive faces. However, there was no attentional bias for sad faces at either evaluation time. Conclusion: The preliminary nature of our findings notwithstanding, this study is the first to provide evidence of behavioural activation impact on attentional selectivity vis-à-vis positive material. [less ▲]

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See detailATG9A Is Overexpressed in Triple Negative Breast Cancer and Its In Vitro Extinction Leads to the Inhibition of Pro-Cancer Phenotypes
Claude-Taupin, Aurore; Fonderflick, Leïla; Gauthier, Thierry et al

in Cells (in press)

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See detailContribution à un lexique épigraphique: "deltographéma"
Famerie, Etienne ULiege

in Zeitschrift für Papyrologie und Epigraphik (in press)

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See detailEntre Francia y Colombia: entrevista a Pablo Montoya
Licata, Nicolas ULiege; Conrod, Tamara

in Caravelle: Cahiers du Monde Hispanique et Luso-Bresilien (in press), 111

Después de realizar estudios de música y filosofía y letras, Pablo Montoya (Barrancabermeja, Colombia, 1963) obtuvo un doctorado en Estudios Hispánicos y Latinoamericanos en la Universidad de la Sorbona ... [more ▼]

Después de realizar estudios de música y filosofía y letras, Pablo Montoya (Barrancabermeja, Colombia, 1963) obtuvo un doctorado en Estudios Hispánicos y Latinoamericanos en la Universidad de la Sorbona-París 3. Actualmente es profesor titular de literatura en la Universidad de Antioquia, en Colombia. Su bibliografía incluye, entre otras obras, los libros de cuentos El beso de la noche (2010) y Adiós a los próceres (2010), así como las novelas Lejos de Roma (2008), Los derrotados (2012) y Tríptico de la infamia (2014), con la cual ganó el prestigioso Premio Rómulo Gallegos, en 2015, y el Premio José María Arguedas, en 2017. Su último libro publicado, titulado Terceto y aparecido en 2016, es difícilmente clasificable. Se trata de una antología de 195 textos escritos a lo largo de treinta años, poemas en prosa en los cuales, cuando no se pone en los zapatos de un astronauta o de un inmigrante africano, el autor da voz a una serie de figuras mitológicas e históricas variadas, de Ícaro a Magritte, pasando por Beethoven. Aparte de esta producción ficcional Pablo Montoya es igualmente traductor, y autor de una importante obra crítica. Entre sus ensayos se puede mencionar La música en la obra de Alejo Carpentier (2013), Novela Histórica en Colombia: entre la pompa y el fracaso (2009) así como Un Robinson cercano (2013), en el que analiza las obras de una serie de escritores franceses del siglo veinte, como Albert Camus, Louis Ferdinand Céline y Michel Houellebecq. En esta entrevista, el escritor colombiano vuelve sobre el período de su vida pasado en Francia y comenta su relación con la literatura francófona, que ha traducido. Aborda también el tema de la violencia en Colombia y su último novela, La escuela de música. [less ▲]

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See detailUn regard post-coloniliste de la médiatisation européenne à l'heure des Femen en Tunisie
Luceno Moreno, Marta ULiege

in Open Library of Humanities (in press)

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See detailClassic Vulvar Intraepithelial Neoplasia With Superimposed Lichen Simplex Chronicus: A Unique Variant Mimicking Differentiated Vulvar Intraepithelial Neoplasia.
Watkins, Jaclyn; Yang, Eric; Crum, Christopher et al

in International Journal of Gynecological Pathology (in press)

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See detailLes origines de la médecine en Égypte
Marganne, Marie-Hélène ULiege

in Journal of the Social History of Medicine and Health (in press)

Renommée depuis la plus haute antiquité pour son ancienneté et son excellence, la médecine égyptienne a-t-elle pu influencer la médecine occidentale et, si tel est le cas, en quoi et de quelle manière ... [more ▼]

Renommée depuis la plus haute antiquité pour son ancienneté et son excellence, la médecine égyptienne a-t-elle pu influencer la médecine occidentale et, si tel est le cas, en quoi et de quelle manière ? Que s’est-il passé lorsque la médecine grecque héritée d'Hippocrate a été importée en Égypte à la suite de la conquête du pays par Alexandre le Grand, en 332 avant notre ère ? Après avoir comparé les écrits médicaux égyptiens et grecs et les pratiques médicales attestées dans le Pays du Nil et dans le monde hellénique, on examinera, à côté des sources littéraires qui font de l' « école médicale d'Alexandrie » un modèle qui restera pour longtemps inégalé, les papyrus médicaux grecs (des IVe/IIIe siècles avant notre ère au VIIe siècle de notre ère), retrouvés en nombre sans cesse croissant dans les sables égyptiens, ainsi que d'autres sources archéologiques, en vue de répondre à ces questions. [less ▲]

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See detailExploration of relationship between parental distress, family functioning and post-traumatic symptoms in children
Gallo, Alicia ULiege; Wertz, Céline ULiege; Kairis, Sophie et al

in European Journal of Trauma and Dissociation (in press)

We investigated the links between peritraumatic distress in children and in their parents following a potentially traumatic event, focusing specifically on the role that parents and family functioning can ... [more ▼]

We investigated the links between peritraumatic distress in children and in their parents following a potentially traumatic event, focusing specifically on the role that parents and family functioning can play in the development and maintenance of post-traumatic disorders in children. To this end, we examined a population of 41 children (aged 8 and above), and their parents, who had been admitted to the emergency room of a pediatric hospital due to an accident. The design included a two-step assessment: immediate reactions (in the hours following the event) and delayed reactions (5-8 weeks after the event). We used six questionnaires to assess reactions. The results indicated a statistically significant positive correlation between the intensity of the peri-traumatic distress of the parents and the level of post-traumatic symptoms observed later (5 to 8 weeks after the event) in the questionnaires administered to the children. Regarding educational practices, differences appear to be linked to maternal education practice and to the severity of child’s symptomatology. Finally, a link has been established between changes within the family dynamic after a potentially traumatic event and the severity of child’s post traumatic symptoms. This study showed the extent to which the parents’ initial reactions can be decisive in the outcome for a child who has experienced a potentially traumatic event. The study highlights the importance of assessing parental responses as well as paying attention to the children when they arrive in a pediatric emergency room. The results are relevant for prevention and treatment of PTSD in children, as the integration of this parental dimension early on in the process may lead to improved identification of which young patients are at risk of developing post-traumatic symptomatology. [less ▲]

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See detailModelling of short-term interactions between concrete support and the excavated damage zone around galleries drilled in Callovo-Oxfordian claystone
Argilaga, Albert ULiege; Collin, Frédéric ULiege; Lacarrière, Laurie et al

in International Journal of Civil Engineering (in press)

Production of energy from nuclear power plants generates high-level radioactive nuclear waste, harmful during dozens of thousand years. Deep geological disposal of nuclear waste represents the most ... [more ▼]

Production of energy from nuclear power plants generates high-level radioactive nuclear waste, harmful during dozens of thousand years. Deep geological disposal of nuclear waste represents the most reliable solutions for its safe isolation. Confinement of radioactive wastes relies on the multi-barrier concept in which isolation is provided by a series of engineered (canister, backfill) and natural (host rock) barriers. Few underground research laboratories have been built all over the world to test and validate storage solutions. The underground drilling process of disposal drifts may generate cracks, fractures/strain localisation in shear bands within the rock surrounding the gallery especially in argillaceous rocks. These degradations affect the hydro-mechanical properties of the material, such as permeability, e.g. creating a preferential flow path for radionuclide migration. Hydraulic conductivity increase within this zone must remain limited to preserve the natural barrier. In addition galleries are currently reinforced by different types of concrete supports such as shotcrete and/or prefab elements. Their purpose is twofold: avoiding partial collapse of the tunnel during drilling operations and limiting convergence of the surrounding rock. Properties of both concrete and rock mass are time dependent, due to shotcrete hydration and hydromechanical couplings within the host rock. By the use of a hydro-mechanical coupled Finite Element Code with a Second Gradient regularization, this paper aims at investigating and predicting support and rock interactions (convergence, stress field). The effect of shotcrete hydration evolution, spraying time and use of compressible wedges is studied in order to determine their relative influence. [less ▲]

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See detailExposure of workers to pesticide residues during re-entry activities: A Review
Toumi, Khaoula ULiege; Joly, Laure; Vleminckx, Christiane et al

in Human and Ecological Risk Assessment (in press)

Workers may be exposed to pesticide residues when they enter an area that has been previously treated in order to realize different tasks (e.g. for pruning, cutting, picking, harvesting, pest scouting) or ... [more ▼]

Workers may be exposed to pesticide residues when they enter an area that has been previously treated in order to realize different tasks (e.g. for pruning, cutting, picking, harvesting, pest scouting) or to handle a contaminated crop commodity (e.g. sorting, bundling, packing). A review of the scientific literature on workers exposed to pesticide residues during re-entry tasks provides a comprehensive view of possible exposure routes and a better understanding of the risk assessment context, threshold values and calculation methodology. Methods assessing the risk to workers health are also reported and discussed. The impact of re-entry activities on health and factors affecting workers exposure are examined. Finally, solutions and mitigation measures aiming to reduce their exposure to pesticide residues are recommended. [less ▲]

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See detailTwo New Ur III Letters in the Louvre Museum
Colonna d'Istria, Laurent ULiege

in Rivista Degli Studi Orientali (in press)

This article provides the publication of two new Ur III letters kept at Louvre Museum. The content of these letters is concise as the majority of the Ur III administrative letters. The first one asks for ... [more ▼]

This article provides the publication of two new Ur III letters kept at Louvre Museum. The content of these letters is concise as the majority of the Ur III administrative letters. The first one asks for the return of persons before an inspection and the second letter asks for the release of one barge carrying sesame. [less ▲]

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See detailPatients’ preferences for osteoarthritis treatment: the value of stated-preference studies.
Hiligsmann, M.; Pinto, D.; Dennison, E et al

in Aging Clinical and Experimental Research (in press)

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See detailMeasuring dating violence: Conflict or non-conflict related instructions?
Courtain, Audrey ULiege; Glowacz, Fabienne ULiege

in European Review of Applied Psychology (in press)

Introduction. – Dating violence, as well as the broader field of intimate partner violence, has mainly been investigated with two conflict-related questionnaires (Conflict in Adolescent Dating ... [more ▼]

Introduction. – Dating violence, as well as the broader field of intimate partner violence, has mainly been investigated with two conflict-related questionnaires (Conflict in Adolescent Dating Relationship Inventory CADRI, Conflict Tactics Scale CTS). Indeed, the respondents have to report aggressive behaviors that occurred in a context of conflict. Such conflict-related instructions prevent us from investigating violence occurring outside a context of conflict. Objective. – The aim of the study was to explore whether the use of a conflict-related or a non-conflict-related version of the CADRI could impact dating violence prevalences and scores, and to investigate conceptual issues associated with conflict-related questionnaires.Method. – A total of 186 participants ranging in age from 16 to 23 years (M = 18.93, SD = 1.52, 64.5%girls) were administered a new version of the CADRI (i.e. with non-conflict related instructions) and then the original version of the CADRI (i.e. with conflict-related instructions). The instrument investigated threatening behaviors, relational, physical, sexual and verbal dating violence. Results. – For several forms of dating violence, prevalence rates and scores decreased from the non-conflict-related version to the conflict-related version: males showed more frequent drops than females.There were more frequent gender differences for rates and scores on the conflict-related version than onthe non-conflict-related version. Conclusion. – The use of non-conflict-related instructions is an opportunity not to limit the study of dating violence to behaviors occurring during a conflict or an argument. It allows a broader understanding ofdating violence beyond any conflict-related instruction. [less ▲]

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See detailProcedural generation of flood-sensitive urban layouts
Mustafa, Ahmed Mohamed El Saeid ULiege; Zhang, Xiao Wei; Aliaga et al

in Environment and Planning B: Urban Analytics and City Science (in press)

Aside from modeling geometric shape, three-dimensional (3D) urban procedural modeling has shown its value in understanding, predicting and/or controlling effects of shape on design and urban planning. In ... [more ▼]

Aside from modeling geometric shape, three-dimensional (3D) urban procedural modeling has shown its value in understanding, predicting and/or controlling effects of shape on design and urban planning. In this paper, instead of the construction of flood resistant measures, we create a procedural generation system for designing urban layouts that passively reduce water depth during a flooding scenario. Our tool enables exploring designs that passively lower flood depth everywhere or mostly in chosen key areas. Our approach tightly integrates a hydraulic model and a parameterized urban generation system with an optimization engine so as to find the least cost modification to an initial urban layout design. Further, due to the computational cost of a fluid simulation, we train neural networks to assist with accelerating the design process. We have applied our system to several real-world locations and have obtained improved 3D urban models in just a few seconds. [less ▲]

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See detailL'espace transitionnel winnicotien et l'_Urraum_ kantien
Seba, Jean-Renaud ULiege

in Revista Natureza Humana (in press)

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See detailLa tradition manuscrite de la « Post-Vulgate ». Histoire d’une diaspora textuelle
Morato, Nicola ULiege

in Revue de Linguistique Romane (in press)

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See detailPhosphate wasting disorders in adults
Marcucci, G; Masi, L; Ferrari, S et al

in Osteoporosis International (in press)

A cause of hypophosphatemia is phosphate wasting disorders. Knowledge concerning mechanisms involved in phosphate wasting disorders has greatly increased in the last decade by the identification of ... [more ▼]

A cause of hypophosphatemia is phosphate wasting disorders. Knowledge concerning mechanisms involved in phosphate wasting disorders has greatly increased in the last decade by the identification of phosphatonins, among them FGF-23. FGF-23 is a primarily bone derived factor decreasing renal tubular reabsorption of phosphate and the synthesis of calcitriol. Currently, pharmacological treatment of these disorders offers limited efficacy and is potentially associated to gastrointestinal, renal, and parathyroid complications; therefore, efforts have been directed toward newer pharmacological strategies that target the FGF-23 pathway. This review focuses on phosphate metabolism, its main regulators, and phosphate wasting disorders in adults, highlighting the main issues related to diagnosis and current and new potential treatments. [less ▲]

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See detailRiver habitat homogenisation enhances trophic competition and promotes individual specialisation among young of the year fish
Latli, Adrien; Michel, Loïc ULiege; Lepoint, Gilles ULiege et al

in Freshwater Biology (in press)

In large rivers, the success of ontogenic development of fish is mainly influenced by resource availability and by the possibility of species to adapt their diet (i.e. trophic niche). Human have ... [more ▼]

In large rivers, the success of ontogenic development of fish is mainly influenced by resource availability and by the possibility of species to adapt their diet (i.e. trophic niche). Human have drastically modified freshwater habitats, notably for navigation purposes. Such modifications may drastically affect food availability for young of the year (YOY) fish and, consequently, influence their ability to reach the adult age. In the River Meuse, a decrease of fish abundance is thought to be linked to a drastic decrease of phytoplankton biomass. In this context of lowering phytoplankton biomass, we quantified the trophic niches of three cyprinid species (common bleak Alburnus alburnus, chub Squalius cephalus, and roach Rutilus rutilus) and one percid species (European perch Perca fluviatilis) at various stages of development, in order to estimate the influence of river channelization in the intra and interspecific competitions. It was done using stable isotope analysis in two reaches of the River Meuse differing by their degree of regulation. We hypothesized that habitat heterogeneity increases YOY abundance over time by offering more alternative resources which reduce food competition, notably during the early period of life. Our study provides evidence that the River Meuse flow and depth regulation significantly impacted the abundance and taxonomic diversity of YOY. In the context of low planktonic biomass, most YOY relied on benthic food sources. In the heavily channelized reach, between-stages competition and low resource diversity increased the diet partition between cyprinid larvae and forced a part of individuals to consume non-optimal energetic food sources such as aquatic vegetation. On the other hand, in the less channelized reach, larvae displayed a generalist feeding habit focusing on energetic prey such as different taxa of macroinvertebrates, suggesting that the diversity of habitat reduces the food competition within and between stages and the predation risk. Developing a sustainable and integrated river management may be useful for protecting biodiversity and restoring ecosystem function, in order to improve the ecological potential of regulated rivers. [less ▲]

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See detailUsing a penalty term to deal with spurious oscillations in second gradient finite elements
Soufflet, Marc; Jouan, Gwendal; Kotronis, Panagiotis et al

in International Journal of Damage Mechanics (in press)

It is well known that it is necessary to introduce a length scale parameter in a continuum damage mechanics model to correctly simulate strain localization. The second gradient model, a special case of ... [more ▼]

It is well known that it is necessary to introduce a length scale parameter in a continuum damage mechanics model to correctly simulate strain localization. The second gradient model, a special case of kinematically enriched continua, considers an internal length parameter by taking into account the second order derivatives of the displacements in the virtual power principle. In this paper, we show that the original second gradient finite element of Chambon and co-workers can present spurious oscillations, especially for mode I crack propagation problems. After providing the plane stress second gradient constitutive law, we propose to add a penalty term in the original formulation in order to improve numerical convergence and to avoid spurious oscillations in the local variables distributions. Two numerical examples using classical damage mechanics laws, a three points reinforced concrete beam and a trapezoidal notched specimen are used to test the performance of the formulation. Parametrical studies are also shown on the influence of the penalty parameter. The problem of unrealistic damage spreading for damage values close to one, occurring often in mode I crack propagation problems, is finally discussed. [less ▲]

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See detailSpectral Echoes in Caryl Phillips’s The Nature of Blood
Mascoli, Giulia ULiege

in Lectures du Monde Anglophone (in press)

In A New World Order (2001) Caryl Phillips claims that “every writer discovers that his or her main struggle is with this one world: form” (293). His struggle with form bears on questions such as how to ... [more ▼]

In A New World Order (2001) Caryl Phillips claims that “every writer discovers that his or her main struggle is with this one world: form” (293). His struggle with form bears on questions such as how to write about unbearably painful lives, how to mirror the trauma undergone by his characters, or how to speak about the unspeakable. Phillips seems to have found a stylistic device enabling him to offer the readers a sense of his characters’ traumatic experience and mirror their emotional state: the musicalization of his prose. Phillips’s use of what I call musical writing is striking in his 1997 novel The Nature of Blood, especially in the sections devoted to Eva. This essay offers an interpretation of Phillips’s musical prose through close readings of Eva’s story and explores how the author’s musical stylization can also reflect the two different ways of approaching traumatic experience suggested by Dominick LaCapra’s: “acting out” and “working through” (Writing 21–2, History 54,104). This piece also shows how through stylistic devices akin to music Phillips resorts to a language which both seeks and defies the reader’s understanding, thereby avoiding any easy identification with Eva. [less ▲]

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See detailIllness perceptions explain the variance in functional disability, but not habitual physical activity, in patients with chronic low back pain: A cross-sectional study
Leysen, Marijke; Nijs, Jo; Van Wilgen, Paul et al

in Pain Practice (in press)

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See detailFrench translation and validation of the exercise-induced leg pain Questionnaire
Beaudart, Charlotte ULiege; Hagelstein, Thibaut; Van Beveren, Julien et al

in Disability and Rehabilitation (in press)

Objective: The “Exercise-Induced Leg Pain” questionnaire was developed (in German) for the evaluation of the severity of symptoms and sports ability in individuals with exercise-induced leg pain. The ... [more ▼]

Objective: The “Exercise-Induced Leg Pain” questionnaire was developed (in German) for the evaluation of the severity of symptoms and sports ability in individuals with exercise-induced leg pain. The purpose of the present study was to translate and cross-culturally adapt this questionnaire into French and to study the reliability and validity of this French-language version. Methods: The translation and cross-cultural adaptation of the original “Exercise-Induced Leg Pain” was performed according to established guidelines. The translation part was carried out in six stages: (i) two initial translations from German to French; (ii) synthesis of the two translations; (iii) backward translations; (iv) comparison between the backward translations and the original questionnaire by an expert committee; (v) pretest; and (vi) approval of the final version of the French-language “Exercise-Induced Leg Pain” questionnaire. To validate this questionnaire, 84 subjects were recruited (28 pathological patients with a confirmed diagnosis of chronic leg pain, 28 asymptomatic sport students, and 28 healthy control athletes). The discriminative power of the questionnaire was tested, as well as its reliability (internal consistency and test–retest reliability after a 7–10-day interval), construct validity and floor/ceiling effects. Results: The French version of the “Exercise-Induced Leg Pain” questionnaire was generated without any major difficulties. The ability of the questionnaire to discriminate between the three groups of subjects was demonstrated with a total score of 61.0 ± 18.5 for the pathologic group; 93.9 ± 7.57 for the asymptomatic group and 94.1 ± 9.79 for the control group. A high internal consistency (Cronbach's alpha of 0.93) and an excellent test–retest reliability [intraclass coefficient correlation: 0.98 (95% confidence interval: 0.97–0.99, p < 0.001)] indicated that the “Exercise-Induced Leg Pain” is reliable. The questionnaire also demonstrated good construct validity against different subscales of the Short Form-36 questionnaire, a generic quality of life questionnaire, with more than 87% of the prespecified hypotheses confirmed. Finally, no floor effects or ceiling effects were observed. Conclusion: The French version of the « Exercise-Induced Leg Pain » was successfully translated and cross-culturally adapted. The questionnaire is consistent, valid and reliable for evaluating French-speaking patients with chronic exercise-induced leg pain. Implications for rehabilitation The “Exercise-Induced Leg Pain” questionnaire aims to assess the severity of symptoms that impact the function and sports ability of patients with exercise-induced leg pain; The French version of the « Exercise-Induced Leg Pain » was successfully translated and cross-culturally adapted. The questionnaire is consistent, valid and reliable for evaluating French-speaking patients with chronic exercise-induced leg pain. [less ▲]

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See detailDo metaphors matter? The impact of a metaphor on citizens’ representations and preferences about federalism
Dodeigne, Jérémy ULiege; Perrez, Julien ULiege; Reuchamps

in Regional and Federal Studies (in press)

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See detailMunicipalities' understanding of the Smart City concept: An exploratory analysis in Belgium
Desdemoustier, Jonathan ULiege; Crutzen, Nathalie ULiege; Giffinger, Rudolf

in Technological Forecasting and Social Change (in press)

The Smart City is a fuzzy concept, which integrates numerous characteristics, components and dimensions. These characteristics are challenged in the academic literature, especially the technocentric ... [more ▼]

The Smart City is a fuzzy concept, which integrates numerous characteristics, components and dimensions. These characteristics are challenged in the academic literature, especially the technocentric approach and the central position of private companies. Moreover, the lack of proper conceptualisation pushes cities to claim themselves ‘smart’. Finally, there are few rigorous analytical or statistical analyses of the concept and its application to territories. Therefore, this paper studies how Belgian municipalities understand the concept of Smart Cities in 2016. Based on the groundwork of literature on Smart Cities and the results of a survey of 113 Belgian municipalities, a typology of four understandings of the Smart City (technological, societal, comprehensive and non-existent) is elaborated. The results also show that municipalities with no understanding of the Smart City concept or with a technical understanding are mostly located in small and rural municipalities. This could be a sign of rejection of the phenomenon in this context. Conversely, medium and large-sized municipalities mostly develop a societal or comprehensive understanding. Therefore, this study highlights a dichotomy of understanding and acceptance of the concept of the Smart City between peripheral (rural and small size municipalities) and central municipalities (urban, medium and large size municipalities). [less ▲]

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See detailThree-Year Adverse Health Consequences of Sarcopenia in Community-Dwelling Older Adults According to 5 Diagnosis Definitions
Locquet, Médéa ULiege; Beaudart, Charlotte ULiege; Hajaoui, Manon ULiege et al

in Journal of the American Medical Directors Association (in press)

Objectives: To assess the occurrence of 3 major adverse outcomes of sarcopenia (ie, physical disabilities, institutionalizations and deaths) observed over a 3-year follow-up in older adults and compare ... [more ▼]

Objectives: To assess the occurrence of 3 major adverse outcomes of sarcopenia (ie, physical disabilities, institutionalizations and deaths) observed over a 3-year follow-up in older adults and compare the risk of these outcomes using 5 definitions of sarcopenia. Design: The study is a part of the ongoing SarcoPhAge (for Sarcopenia and Physical Impairment with advancing Age) longitudinal project. Setting and Participants: The SarcoPhAge study follows 534 community-dwelling older adults. Measures: Sarcopenia was defined as low muscle mass plus a decreased muscle function. Data on adverse outcomes were collected yearly during the annual follow-up or with a phone call. The association between baseline sarcopenia and the occurrence of undesirable outcomes was tested using the Cox proportional hazards model or a logistic regression model. Results: A total of 534 subjects were recruited into this prospective cohort (73.5 6.2 years, 60.5% female). After 3 years, 33 participants were lost to follow-up. If no association between baseline sarcopenia and physical disabilities or institutionalizations was highlighted, a higher number of deaths occurred in individuals diagnosed with sarcopenia than in those who were not diagnosed (16.2% vs 4.6%, P value <.001). The probability of death within 3 years when presenting with sarcopenia showed an approximately 3-fold increase compared to subjects without sarcopenia. Conclusion: Over a 3-year period, sarcopenia at baseline was associated with an increased risk of mortality. There were some variations in the ability of different definitions of sarcopenia to predict outcomes. [less ▲]

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See detailLes haruspices publics au service de Rome : des aristocrates convoqués d’Étrurie ? Quels aristocrates ?
Berthelet, Yann ULiege

in Dialogues d'Histoire Ancienne (in press)

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See detailLes principes de répartition des compétences dans la jurisprudence de la Cour constitutionnelle
Rosoux, Géraldine ULiege

in Administration Publique: Revue du Droit Public et des Sciences Administratives (in press)

Cet article dégage trois catégories de "principes" de la répartition des compétences dans la jurisprudence de la Cour constitutionnelle. Ces principes permettent de comprendre la chronologie du ... [more ▼]

Cet article dégage trois catégories de "principes" de la répartition des compétences dans la jurisprudence de la Cour constitutionnelle. Ces principes permettent de comprendre la chronologie du raisonnement de la Cour constitutionnelle en matière de répartition des compétences. [less ▲]

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See detailOPECST et le nucléaire: retour sur 27 ans d'évaluation de gestion des déchets hautement radioactifs
Parotte, Céline ULiege

in Histoire de la Recherche Contemporaine : la Revue pour l’Histoire du CNRS (in press), VIII

How to assess the high-level radioactive waste (HLRW) controversial issue during decades? OPECST is almost the only one that had accepted to do it regularly. Following 27 years of assessments, this ... [more ▼]

How to assess the high-level radioactive waste (HLRW) controversial issue during decades? OPECST is almost the only one that had accepted to do it regularly. Following 27 years of assessments, this article highlights the different assessments and its consequences on the HLRW program and the role of the assessor. [less ▲]

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See detailIPCAPS: an R package for iterative pruning to capture population structure
Chaichoompu, Kridsadakorn ULiege; Abegaz Yazew, Fentaw; Tongsima, Sissades et al

in Bioinformatics (in press)

Resolving population genetic structure is challenging, especially when dealing with closely related populations. Although Principal Component Analysis (PCA)-based methods and genomic var- iation with ... [more ▼]

Resolving population genetic structure is challenging, especially when dealing with closely related populations. Although Principal Component Analysis (PCA)-based methods and genomic var- iation with single nucleotide polymorphisms (SNPs) are widely used to describe shared genetic an- cestry, improvements can be made targeting fine-level population structure. This work presents an R package called IPCAPS, which uses SNP information for resolving possibly fine-level population structure. The IPCAPS routines are built on the iterative pruning Principal Component Analysis (ipP- CA) framework to systematically assign individuals to genetically similar subgroups. Our tool is able to detect and eliminate outliers in each iteration to avoid misclassification. It can be extended to de- tect subtle subgrouping in patients as well. In addition, IPCAPS supports different measurement scales for variables used to identify substructure. Hence, panels of gene expression and methylation data can be accommodated. [less ▲]

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See detail"But the Cold World Shall Not Know:" A Reading of Shelley's "Julian and Maddalo" as a Detective Stor
Dechene, Antoine ULiege

in Clues: A Journal of Detection (in press)

This essay offers a reading of Shelley's "Julian and Maddalo" as a Detective Story, or rather, as a metacognitive mystery tale. The poem indeed asks important questions about the possibility and ... [more ▼]

This essay offers a reading of Shelley's "Julian and Maddalo" as a Detective Story, or rather, as a metacognitive mystery tale. The poem indeed asks important questions about the possibility and reliability of knowledge. The detective-poet's quest for higher truths is confronted with the impenetrable forces of the sublime and the grotesque and is thus bound to remain unfulfilled. Interpretation is further complicated as the roles of detective, criminal, and victim are gradually interwoven and Julian's faith in human free will is threatened by a reality in which mere chance leads those who desperately try to produce meaning to madness and death. [less ▲]

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See detailHumor Associated with Positive Outcomes in Individual Psychotherapy
Panichelli, Christophe ULiege; Albert, Adelin ULiege; Donneau, Anne-Françoise ULiege et al

in American Journal of Psychotherapy (in press), APT-2018-0021

Considerable anecdotal evidence points to the usefulness of humor in the therapeutic process, but empirical evidence is still lacking. This study searched for an association between humor and therapy ... [more ▼]

Considerable anecdotal evidence points to the usefulness of humor in the therapeutic process, but empirical evidence is still lacking. This study searched for an association between humor and therapy outcomes in a real-life population of 110 adult psychotherapy clients who attended at least 10 therapy sessions. Clients and their therapist evaluated the frequency and intensity of humorous events, as well as therapy effectiveness, therapeutic alliance, perceived hope and pleasure to participate in therapy sessions. We found a strong positive correlation between humor and therapy effectiveness, in both client (rs = .40; p < .0001) and therapist perspectives (rs = .37; p < .0001). The link between humor and effectiveness remained significant in more severe subgroups of clients, even though these clients reported less humor in their therapies. Further research is needed to determine if humor actually enhances therapy outcomes, or if positive outcomes trigger the occurrence of humor. [less ▲]

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See detailTracing Lost Editions of Parisian Printers in the Sixteenth Century: The Case of Jean Bonfons and his Widow
Adam, Renaud ULiege

in The Library: The Transactions of the Bibliographical Society (in press)

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See detailMediterranean diet and knee osteoarthritis outcomes: a longitudinal cohort study.
Veronese; Koyanagi, A.; Stubbs, B. et al

in Clinical Nutrition (in press)

Objectives: Mediterranean diet has several beneficial effects on health, but data regarding the association between Mediterranean diet and knee osteoarthritis (OA) are limited mainly to cross-sectional ... [more ▼]

Objectives: Mediterranean diet has several beneficial effects on health, but data regarding the association between Mediterranean diet and knee osteoarthritis (OA) are limited mainly to cross-sectional studies. We investigated whether higher Mediterranean diet adherence is prospectively associated with lower risk of radiographic OA (ROA), radiographic symptomatic knee OA (SxOA) and pain worsening in North American people at high risk or having knee OA. Methods: Adherence to the Mediterranean diet was evaluated using a validated Mediterranean diet score (aMED), categorized in five categories (Q1 to Q5, higher values reflecting higher adherence to Mediterranean diet). Knee OA outcomes included incident (1) ROA, (2) SxOA, as the new onset of a combination of a painful knee and ROA, (3) knee pain worsening, i.e. a Western Ontario and McMaster Universities Osteoarthritis Index difference between baseline and each annual exam of 14%. Results: 4330 subjects (mean age: 61.1 years; 58.0% females) were included. Based on a multivariable Poisson regression analysis, during a mean follow-up period of 4 years, participants who were more highly adherent to a Mediterranean diet (Q5) reported lower risk of pain worsening (relative risk, RR ¼ 0.96; 95% CI: 0.91e0.999) compared to those in Q1. In 2994 people free from SxOA at baseline, higher adherence to a Mediterranean diet was associated with a lower risk for SxOA during follow-up by 9% (Q5 vs. Q1; RR ¼ 0.91; 95% CI: 0.82e0.998). No significant associations emerged between aMED and incident ROA. [less ▲]

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See detailRéduire l’altérité au travers des processus de traduction et de représentation
Leclercq, Bruno ULiege; Smette, Bernard ULiege

in Doctorales. Revue LLA-SHS de Montpellier (in press)

WVO Quine questions the « myth » of an ideal realm of shared meanings which every national language would express in its own way. Against the hope of transparent translations, he insists on the necessity ... [more ▼]

WVO Quine questions the « myth » of an ideal realm of shared meanings which every national language would express in its own way. Against the hope of transparent translations, he insists on the necessity for building equivalences from one language to another through a strategy of reducing the differences in rationality among nations as much as possible. According to Quine, otherness is not insuperable impediment to meeting/encounter and mutual understanding ; by throwing our conceptual schemes on the other communities’ uses/practices – which of course involves some symbolic violence – gaps can always been narrowed. Similarly E. Laclau questions the traditional conception of political representation, which is seen as the transparent process of transmitting someone’s will or interests on another level. For this ideal conception of representation, Laclau substitutes a pragmatic conception which takes in account the irreducible gap between the actors as well as the constitutive opacity of the process of representation : the subject’s will is constituted within the process of representation and through the representative’s productive role. In order to be transposed at the decision-making level, the subject’s interests must be translated by the representative as well as be negotiated with the other represented interests. This implies that the initial will undergoes some identity transformations. [less ▲]

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See detailUnveiling heterogeneous engagement-based loyalty in brand communities
Dessart, Laurence ULiege; Aldas-Manzano, Joachin; Veloutsou, Cleopatra

in European Journal of Marketing (in press)

Although recent research appreciates that consumers increasingly interact with brands in brand communities and that brand engagement is an important and complex phenomenon in brand communities, little is ... [more ▼]

Although recent research appreciates that consumers increasingly interact with brands in brand communities and that brand engagement is an important and complex phenomenon in brand communities, little is known on the nature of individuals’ brand engagement in brand communities. This study aims to: (a) identify brand community members’ segments in terms of their brand engagement within the community (b) help us understand if these segments employ a different approach in the development of brand loyalty and (c) develop mechanisms that can be used to identify members of these segments. [less ▲]

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See detailPlace des « thérapies lumière » auprès des personnes âgées souffrant de pathologie démentielle : état des lieux et perspectives futures
Missotten, Pierre ULiege; Farag, Laurent ULiege; Delye, Samuel et al

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (in press)

Background. Given the relatively modest therapeutic benefits of drug treatments (and their associated costs) in dementia, there is growing interest in non-pharmalogical approaches, including light therapy ... [more ▼]

Background. Given the relatively modest therapeutic benefits of drug treatments (and their associated costs) in dementia, there is growing interest in non-pharmalogical approaches, including light therapy (« Light Based Therapy » ; LBT). Although various literature review exist, little attention has been given to the effects of these therapies (according to their modalities of application) on parameters related to both circadian rhythm and clinical parameters associated with dementia. Aims. To provide an overview of available studies using LBT as non-pharmacological approach for managing persons with dementia and to make recommendations for its use. Method. Systematic searches in Medline and PsycINFO were carried out, from their inception to February 2017, by means of the combination of key words including dementia and light therapy. Results. Forty-two articles were reviewed with particular attention to the subjects characteristics and the modalities of the therapy. The effect of LBT has been considered as a mean of intervention to entrain the circadian rhythm as well as in a clinical approach to reduce behavioral disorders, to reduce cognitive decline or loss of independence, and so on. Depending on the parameters and modalities, the effect of LBT is partially or non-significant. Conclusions. Based on this literature review, some recommendations were formulated: prioritizing ‘naturalistic’ devices, setting a minimum threshold of 2,000 lux light intensity peak, testing the modulation of the light intensity during the day and finally, assessing the adequacy between the type of light (color) and the desired therapeutic objective (relaxing or stimulating effect). [less ▲]

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See detailPerformance sharing in risky portfolios: The case of hedge fund returns and fees
Hübner, Georges ULiege; Lambert, Marie ULiege

in Journal of Portfolio Management (in press)

Institutional investors face various leverage and short-sale restrictions that alter competition in the asset management industry. This distortion enables unconstrained investors with high volatility ... [more ▼]

Institutional investors face various leverage and short-sale restrictions that alter competition in the asset management industry. This distortion enables unconstrained investors with high volatility targets to extract additional income from constrained institutional investors. Using a sample of 1,938 long/short equity hedge funds spanning 15 years, the authors show that high-volatility funds charge higher fees and deliver lower net-of-fees Sharpe ratios than do their low-volatility peers. This evidence could be interpreted as a situational rent extraction or as a service compensation. Conversely, increased volatility could result from a manager's ambition to deliver large net information ratios after accounting for a high fee structure. [less ▲]

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See detailPer una edizione integrale e analitica dell'incipit della Storia d'Italia di Francesco Guicciardini
Moreno, Paola ULiege

in Laboratoire Italien: Politique et Société (in press)

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See detailConsensus report: Peri-implant diseases and conditions
Berglundh, Tord; Armitage, Gary; Avila-Ortiz, Gustavo et al

in Journal of Periodontology (in press)

A classification for peri-implant diseases and conditions was presented. Focused questions on the characteristics of peri-implant health, peri-implant mucositis, periimplantitis, and soft- and hard-tissue ... [more ▼]

A classification for peri-implant diseases and conditions was presented. Focused questions on the characteristics of peri-implant health, peri-implant mucositis, periimplantitis, and soft- and hard-tissue deficiencies were addressed. Peri-implant health is characterized by the absence of erythema, bleeding on probing, swelling, and suppuration. It is not possible to define a range of probing depths compatible with health; of more importance are the clinical signs of inflammation. Peri-implant health can exist around implants with reduced bone support.The main clinical characteristic of peri-implant mucositis is bleeding on gentle probing. Erythema, swelling, and/or suppuration may also be present. An increase in probing depth is often observed in the presence of peri-implant mucositis due to swelling or decrease in probing resistance. There is strong evidence from animal and human experimental studies that plaque is the etiological factor for peri-implant mucositis. Peri-implantitis is a plaque-associated pathological condition occurring in tissues around dental implants, characterized by inflammation in the peri-implant mucosa and subsequent progressive loss of supporting bone. Peri-implantitis sites exhibit clinical signs of inflammation, bleeding on probing, and/or suppuration, increased probing depths and/or recession of the mucosal margin in addition to radiographic bone loss. The evidence is equivocal regarding the effect of keratinized mucosa on the longterm health of the peri-implant tissue. It appears, however, that keratinized mucosa may have advantages regarding patient comfort and ease of plaque removal. Case definitions in day-to-day clinical practice and in epidemiological or diseasesurveillance studies for peri-implant health, peri-implant mucositis, and periimplantitis were introduced. The proposed case definitions should be viewed within the context that there is no generic implant and that there are numerous implant designs with different surface characteristics, surgical and loading protocols. It is recommended that the clinician obtain baseline radiographic and probing measurements following the completion of the implant-supported prosthesis. [less ▲]

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See detailBone metabolism markers are associated with neck circumference in adult Arab women.
Albassam, R.S.; Sabico, S.; Alnaami, A.M. et al

in Osteoporosis International (in press)

Summary: The study aimed to determine whether neck circumference is associated with bone metabolism markers among adult Arab women and found modest but significant associations with bone resorption ... [more ▼]

Summary: The study aimed to determine whether neck circumference is associated with bone metabolism markers among adult Arab women and found modest but significant associations with bone resorption markers, suggesting that neck circumference, a surrogate measure of upper subcutaneous fat, influences bone turnover expression among adult females. Introduction: Body fat distribution is associated with decreased bone resorption and neck circumference (NC), a surrogate measure for upper body fat, has never been tested as a marker that can reflect bone turnover. This is the first study aimed to analyze the associations between NC and several bone biomarkers among adult Saudi women. Methods: This cross-sectional study included a total of 265 middle-aged Saudi women [86 non-obese (mean age 52.7 ± 8.1; mean BMI 26.9 ± 2.3) and 179 obese (mean age 50.6 ± 7.5; mean BMI 35.7 ± 4.5)] recruited from primary care centers in Riyadh, Saudi Arabia. Anthropometrics included BMI, NC, waist and hip circumferences, total body fat percentage (%), and blood pressure. Biochemical parameters included glucose and lipid profile which were measured routinely. Serum levels of 25(OH) D, parathyroid hormone, RANKl, sclerostin, C-terminal telopeptide of collagen I (CTX-I), Dkk1, IL1β, osteoprotegerin, osteopontin, and osteocalcin were measured using commercially available assays. Results: In all groups, NC was inversely associated with PTH (R = − 0.22; p < 0.05) and positively associated with osteoprotegerin (R=0.20; p < 0.05) even after adjustments for age and BMI. Using all anthropometric indices as independent variables showed that only NC explained the variance perceived in CTX-I (p = 0.049). In the non-obese, waist-hip ratio (WHR) was significantly associated with sclerostin (R = 0.40; p < 0.05) and body fat was significantly associated with osteopontin (R=0.42; p<0.05). Conclusion: NC is modestly but significantly associated with bone biomarkers, particularly the bone resorption markers, among adult Arab women. The present findings highlight the importance of NC as measure of upper body subcutaneous fat in influencing bone biomarker expression in adult females. [less ▲]

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See detailNyldon words
Charlier, Emilie ULiege; Philibert, Manon; Stipulanti, Manon ULiege

in Journal of Combinatorial Theory. Series A (in press)

The Chen-Fox-Lyndon theorem states that every finite word over a fixed alphabet can be uniquely factorized as a lexicographically nonincreasing sequence of Lyndon words. This theorem can be used to define ... [more ▼]

The Chen-Fox-Lyndon theorem states that every finite word over a fixed alphabet can be uniquely factorized as a lexicographically nonincreasing sequence of Lyndon words. This theorem can be used to define the family of Lyndon words in a recursive way. If the lexicographic order is reversed in this definition, we obtain a new family of words, which are called the Nyldon words. In this paper, we show that every finite word can be uniquely factorized into a lexicographically nondecreasing sequence of Nyldon words. Otherwise stated, Nyldon words form a complete factorization of the free monoid with respect to the decreasing lexicographic order. Then we investigate this new family of words. In particular, we show that Nyldon words form a right Lazard set. [less ▲]

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See detailLevallois et Gravettien
Otte, Marcel ULiege; Noiret, Pierre ULiege

in Praehistoria (in press)

Par opposition à ceux de l’Aurignacien, les ensembles lithiques gravettiens procèdent selon une méthode rappelant le Levallois quant à la préparation des supports. Mais les variations observables au sein ... [more ▼]

Par opposition à ceux de l’Aurignacien, les ensembles lithiques gravettiens procèdent selon une méthode rappelant le Levallois quant à la préparation des supports. Mais les variations observables au sein du Gravettien touchent autant les processus de symbolisation dans l’art et les sépultures. Elles affectent différents substrats eurasiatiques, plutôt septentrionaux, comme mis en réserve dès les Néandertaliens. [less ▲]

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See detailExploration of Dating Violence and Related Attitudes Among Adolescents and Emerging Adults
Courtain, Audrey ULiege; Glowacz, Fabienne ULiege

in Journal of Interpersonal Violence (in press)

Young people’s romantic relationships can be marked with various forms of dating violence (DV). However, adolescents and emerging adults do not necessarily acknowledge this violence because of their ... [more ▼]

Young people’s romantic relationships can be marked with various forms of dating violence (DV). However, adolescents and emerging adults do not necessarily acknowledge this violence because of their attitudes toward dating violence. Our study aims to study dating violence and attitudes toward this phenomenon through two well-established questionnaires administered jointly in their entirety. Indeed, too many studies report results on some dimensions and items, neglecting the richness of available tools. The Conflict in Adolescent Dating Relationship Inventory and the Attitudes Toward Dating Violence Scale were self-administered to 1,014 participants (M age = 18.9) attending secondary schools or a regional college. They reported the frequency of their dating violence perpetration and victimization, and their attitudes toward dating violence. Results show that relational and sexual violence perpetration rates are higher for males, physical violence perpetration rate is higher for females, and relational violence victimization is higher for males. MANCOVAs not only show the same trends for scores but also underline more frequent emotional violence perpetrated by females, physical victimization for males, and sexual victimization for females. Males show higher tolerance toward every form of dating violence; younger participants are also more tolerant. Participants are more tolerant toward male-perpetrated psychological DV than femaleperpetrated ones, and more tolerant toward female-perpetrated physical and sexual DV compared with male-perpetrated physical and sexual DV. There are patterns of multiperpetration, multivictimization, bidirectionality, and multi(in)tolerance. Our paper contributes to the symmetry debate, a better understanding of the link between attitudes and violent behaviors, a further step on gendered attitudes regarding who perpetrates and who sustains. [less ▲]

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See detailConservation Ethics in the 21th Century: Towards an Extended Toolkit
Houbart, Claudine ULiege; Dawans, Stéphane ULiege

in Heritage for Future (in press)

In his now classic essay on the « Régimes d’historicité », the French historian François Hartog (2003) has very well described the effect of globalisation, democratisation and mass consumerism on our ... [more ▼]

In his now classic essay on the « Régimes d’historicité », the French historian François Hartog (2003) has very well described the effect of globalisation, democratisation and mass consumerism on our relation with the past and thus, with heritage. In the course of the 1970’s, at a time when the ink of the Venice Charter was barely dry, postmodernity triggered a loss of collective anchoring and memory, paradoxically accompanied by an amplification of the thirst for commemorations, in the name of identity or heritage. Pierre Nora’s great endeavour « Les lieux de mémoire », fully corresponds to this « presentism » era, including aside from monuments, museum and archives, intellectual constructions such as the Larousse encyclopaedia (Nora 1989). It very well illustrates the « extension of the heritage domain » as defined by the sociologist Nathalie Heinich (2009). In our « post-monumental » era, anything can possibly become heritage, regardless of scale, of artistic qualities, of age or ontological degree – from tangible to intangible. This is a sign of times. Following the example of Nelson Goodman replacing the essentialist definitions of art with the question « When is there art ? » (Goodman 1976), we should consider focusing on a dynamic and operational definition of heritage. The question « When is there heritage ?» better correspond to contemporary cultural studies and our attempt to understand « heritagization »; it contains the idea of a performative action, implying new actors, new dynamics, new process, new research questions, new difficulties and new opportunities. And by necessity new concepts. We are far from rejecting theories from the past which provided us with effective and stimulating tools. But who could still imagine today, in the situation we described, that any system could fully encompass the heritage reality as the grand theories – Brandi, Riegl,… – succeeded to do? The repeated attempts to get the Venice charter revised from the 1970’s on (Houbart 2014), and the multiplication of thematic documents and charters are the best illustration of this impossibility. But while postmodern thinkers made us suspicious towards large systems, they also made us more modest and above all, more inclined to respect « bricolage », as a most helpful attitude after a shipwreck. We believe that the current return to a case by case approach – as promoted from the interwar period by theoreticians such as Ambrogio Annoni (1946) – often mostly relying on practical constraints such as reuse and technical performances, combined with the use of decontextualised concepts – separated articles from the Venice Charter, for example – and practices – using the Ise shrine periodical rebuilding to advocate any reconstruction project – doesn’t mean to accept a cynical relativism in answer to the cause of a capital-intensive machine. But in practice, we cannot deny that it has sometimes been the case: the clearest examples are the debates addressing the reconstruction of monuments all over Europe, based on a jumble of arguments confusing the pure mercantilism of the tourism industry or unconfessed political reasons with post-conflict identity issues or religious traditions (Monumental 2010). Reflecting on such reconstruction projects, raising questions of identity, has convinced us of the incompleteness of the toolkit we inherited from 20th century theoreticians. Though still perfectly relevant to address the issues that were already present at the time when they were elaborated, they might prove inappropriate to address new types of heritage, new concerns, new issues such as cultural tourism, inclusive approaches, modern heritage or the digital turn. In this context, we have been drawn to look at texts outside the conservation sphere, starting from ontology of art and analytical philosophy. We discovered that taking a step to the side could provide a stimulating insight on heritage conservation problems. In fact, it is not surprising that, facing what many have called a heritage inflation, some new actors could help us. Now that heritage has quitted the monuments sphere to encompass any material or immaterial reality worthy of conservation and that the expert point of view is challenged by the ones of a broad range of stakeholders, from the user to the investor, it becomes interesting to look at this reality from different points of view borrowed to a wide range of human sciences such as law, communication, aesthetics, semiotics, anthropology or philosophy, to name a few. Together with our colleague Muriel Verbeeck, we are currently gathering texts in order to propose an anthology that could complement the existing ones in helping to fill conceptual gaps and throw a reinvigorating light on new problems raising old questions. The originality of the project is to chose most texts outside the conservation world, and to address movable and immovable heritage at the same time. During our presentation, we will provide some examples of the usefulness of these new concepts, some already known by a number of conservators – such as the distinction proposed by Nelson Goodman between allography and autography (Goodman 1976) –, some not – the impact of intention on identity, based on texts by Theodore Scaltsas (1981), for example –, and will encourage the members of the committee who might be interested in this approach to contribute to the project. [less ▲]

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See detailModeling of coupled heat and mass transfer during drying of ebony wood using indirect natural convection solar dryer
Simo-Tagne, Merlin; Bonoma, B.; Bennamoun, L. et al

in Drying Technology (in press)

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See detailMotor behavior unmasks residual cognition in disorders of consciousness
Pincherle, Alessandro; Johr, Jane; Chatelle, Camille ULiege et al

in Annals of Neurology (in press)

Disorders of consciousness (DOC) are a common consequence of severe brain injuries, and clinical evaluation is critical to provide a correct diagnosis and prognosis. The revised Motor Behavior Tool (MBT-r ... [more ▼]

Disorders of consciousness (DOC) are a common consequence of severe brain injuries, and clinical evaluation is critical to provide a correct diagnosis and prognosis. The revised Motor Behavior Tool (MBT-r) is a clinical complementary tool aiming to identify subtle motor behaviors that might reflect residual cognition in DOC. In this prospective study including 30 DOC patients in the early stage after brain injury, we show that the revised MBT-r has an excellent inter-rater agreement and has the ability to identify a subgroup of patients, underestimated by the Coma Recovery Scale-Revised, showing residual cognition and a subsequent recovery of consciousness. [less ▲]

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See detailTraditionally managed landscapes do not prevent amphibian decline and the extinction of paedomorphosis
Denoël, Mathieu ULiege; Ficetola, G. Francesco; Sillero, Neftali et al

in Ecological Monographs (in press)

Eco-cultural landscapes are assumed to be favourable environments for the persistence of biodiversity, but global change may affect differently their terrestrial and aquatic components. Yet, few long-term ... [more ▼]

Eco-cultural landscapes are assumed to be favourable environments for the persistence of biodiversity, but global change may affect differently their terrestrial and aquatic components. Yet, few long-term studies have examined how multiple, global change stressors may affect wetland biodiversity in such environments. Facultative paedomorphosis is a spectacular example of intra-specific variation, in which biphasic (metamorphosing) amphibians coexist with fully aquatic conspecifics which do not metamorphose (paedomorphs). Paedomorphosis is seriously threatened by global change stressors, but it is unknown to what extent traditional management will allow its long-term persistence. Here, we tested the effects of alien species introductions while taking into account land-use and climate changes on the distribution of two polymorphic newt species (Ichthyosaura alpestris and Lissotriton graecus) in Montenegro by using a 68-year data set and Bayesian mixed models integrating complex spatial and temporal structures. We found that, despite the persistence of natural landscapes, metamorphs dramatically declined, and paedomorphs were nearly extirpated, losing 99.9% of their aquatic area of occupancy and all the major populations. Fish introduction was the main determinant of decline for both phenotypes. Climate and the presence of crayfish further contributed to the decline of metamorphs, which started later and was less dramatic than that of paedomorphs. The near extinction of paedomorphosis on a country-wide scale shows how invasive species determine broad scale impacts, which can be even stronger than other global change stressors, and underlines the need for immediate management actions to avoid the extinction of a unique developmental process, paedomorphosis. [less ▲]

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See detailA dynamic and screening-compatible nanoluciferase-based complementation assay enables profiling of individual GPCR-G protein interactions
Laschet, Céline ULiege; Dupuis, Nadine; Hanson, Julien ULiege

in Journal of Biological Chemistry (in press)

G protein-coupled receptors (GPCRs) are currently the target of more than 30% of the marketed medicines. However, there is an important medical need for ligands with improved pharmacological activities on ... [more ▼]

G protein-coupled receptors (GPCRs) are currently the target of more than 30% of the marketed medicines. However, there is an important medical need for ligands with improved pharmacological activities on validated drug targets. Moreover, most of these ligands remain poorly characterized, notably because of a lack of pharmacological tools. Thus, there is an important demand for innovative assays that can detect and drive the design of compounds with novel or improved pharmacological properties. In particular, a functional and screening-compatible GPCR-G protein interaction assay is still unavailable. Here, we report on a nanoluciferase-based complementation technique to detect ligands that promote a GPCR-G protein interaction. We demonstrate that our system can be used to profile compounds with regard to the G proteins they activate through a given GPCR. Furthermore, we established a proof of applicability of screening for distinct G proteins on dopamine receptor D2 whose differential coupling to Gαi/o family members has been extensively studied. In a D2-Gαi1 versus D2- Gαo screening, we retrieved five agonists that are currently being used in antiparkinsonian medications. We determined that in this assay, piribedil and pergolide are full agonists for the recruitment of Gαi1 but are partial agonists for Gαo, that the agonist activity of ropinirole is biased in favor of Gαi1 recruitment, and that the agonist activity of apomorphine is biased for Gαo. We proposed that this newly developed assay could be used to develop molecules that selectively modulate a particular G protein pathway. [less ▲]

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See detailExtracorporeal photochemotherapy for graft versus host disease : Where we are now and where are we going !
Lewalle, Philippe; Beguin, Yves ULiege

in Belgian Journal of Hematology (in press)

Graft-versus-host disease (GVHD) remains the leading cause of morbidity, non-relapse mortality and treatment failure post allogeneic hematopoietic stem cell transplantation (allo-HSCT). So far, steroids ... [more ▼]

Graft-versus-host disease (GVHD) remains the leading cause of morbidity, non-relapse mortality and treatment failure post allogeneic hematopoietic stem cell transplantation (allo-HSCT). So far, steroids are the 1st line treatment but around 40% of patients become steroid-resistant or fail to respond at a safe dose. Patients who fail to respond to the initial therapy have a dismal prognosis and no standard treatment is well established for them to date. Treatments that modulate the immune system rather than directly suppressing its function, although not dampening a potential graft-versus-malignancy effect, would therefore be highly desirable and extracorporeal photopheresis (ECP) appeared as being a good candidate to fill in these criteria. Multiple reports of treatments in both paediatric and adult patients with GVHD have been published, and the overall favourable profile compared with other available immunosuppressive therapies continues to make ECP appealing despite all of the unknowns. In this article, we review the use of extracorporeal photopheresis for the treatment of graft-versus-host disease including technical aspects, mechanism of action, safety profile and clinical efficacy data [less ▲]

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See detailIntravenous lipid emulsions in paediatric patients
Lapillonne, A; Didler Mis, N; Goulet et al

in Clinical Nutrition (in press)

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See detailFirst geochimichal sourcing of 'Balkan flint' and 'Prut flint' from Palaeolithic Romania: potentials, limitations and future directions
Moreau, Luc; Ciornei, A.; Gjesfjelds, E. et al

in Archaeometry (in press)

Attributions of flint artefacts to specific geographical sources ideally require some form of independent validation through suitable petrographical and/or geochemical analyses, given the implications of ... [more ▼]

Attributions of flint artefacts to specific geographical sources ideally require some form of independent validation through suitable petrographical and/or geochemical analyses, given the implications of raw material transfer on interpretations of prehistoric mobility and land-use strategies. We investigated the potential to ‘fingerprint’ flint from two archaeological sites in Eastern Romania – Mitoc-Malu Galben and Bistricioara-Lutărie III, using Laser Ablation – Inductively Coupled Plasma – Mass Spectrometry (LA-ICP-MS) in combination with multivariate statistical analysis. Our results suggest that geochemical analyses do not yet have the level of resolution required to assign single artefacts to specific geographic locations in the context of Romania and Bulgaria. The mismatches of signatures between training and test data however raise new questions and open unforeseen perspectives. [less ▲]

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See detailLes Trois Trois Petits Cochons et le Grand Méchant Loup. La rencontre de deux archétypes
Jousten, Lison ULiege

in La revue des lettres modernes (in press)

Image de la menace par excellence, le Grand Méchant Loup est un adversaire dont on ne compte plus les apparitions, notamment dans les fictions destinées au jeune public. Dans Les Trois Petits Cochons, qui ... [more ▼]

Image de la menace par excellence, le Grand Méchant Loup est un adversaire dont on ne compte plus les apparitions, notamment dans les fictions destinées au jeune public. Dans Les Trois Petits Cochons, qui s’impose comme cas d’école parmi ces récits où surgit l’animal redouté, le loup devient l’ennemi du cochon, une créature traditionnellement associée à l’enfance. Ce tandem, qui repose sur un principe général d’opposition, brasse avec lui une série de représentations qui transparaissent en filigrane. Le détour opéré par l’histoire culturelle du cochon et quelques-uns de ses prolongements cinématographiques permet de dessiner progressivement les contours de la place occupée par le loup dans ce conte. [less ▲]

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See detailConsequence of past anthropogenic forest fragmentation on the genetic structure of European mammals: the example of the edible dormouse (Glis glis)
Michaux, Johan ULiege; Hurner, H.; Krystufek, B et al

in Biological Journal of the Linnean Society (in press)

The genetic structure of forest animal species may allow the spatial dynamics of the forests themselves to be tracked. Two scales of change are commonly discussed: changes in forest distribution during ... [more ▼]

The genetic structure of forest animal species may allow the spatial dynamics of the forests themselves to be tracked. Two scales of change are commonly discussed: changes in forest distribution during the Quaternary, due to glacial/ interglacial cycles, and current fragmentation related to habitat destruction. However, anthropogenic changes in forest distribution may have started well before the Quaternary, causing fragmentation at an intermediate time scale that is seldom considered. To explore the relative role of these processes, the genetic structure of a forest species with narrow ecological preferences, the edible dormouse (Glis glis), was investigated in a set of samples covering a large part of its Palaearctic distribution. Strong and complex geographical structure was revealed from the use of microsatellite markers. This structure suggests that fragmentation occurred in several steps, progressively splitting the ancestral population into peripheral isolated ones. The fact that this structure postdates post-glacial recolonization, together with dating based on microsatellite data, supports the hypothesis that the differentiation was recent, starting around 9000 years ago, and took place stepwise, possibly up to Medieval times. This complements a classic phylogeographical interpretation based on the effect of past climate change, and supports the role of anthropogenic deforestation as a trigger of recent intraspecific differentiation. [less ▲]

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See detailLe populisme aux Etats-Unis : le rejet de l’élite
Jamin, Jérôme ULiege

in Amnis : Revue de Civilisation Contemporaine Europes/Amériques (in press), 17

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See detailIdentifying elastoplastic parameters with Bayes' theorem considering double error sources and model uncertainty
Rappel, Hussein ULiege; Beex, Lars A A; Noels, Ludovic ULiege et al

in Probabilistic Engineering Mechanics (in press)

We discuss Bayesian inference for the identification of elastoplastic material parameters. In addition to errors in the stress measurements, which are commonly considered, we furthermore consider errors ... [more ▼]

We discuss Bayesian inference for the identification of elastoplastic material parameters. In addition to errors in the stress measurements, which are commonly considered, we furthermore consider errors in the strain measurements. Since a difference between the model and the experimental data may still be present if the data is not contaminated by noise, we also incorporate the possible error of the model itself. The three formulations to describe model uncertainty in this contribution are: (1) a random variable which is taken from a normal distribution with constant parameters, (2) a random variable which is taken from a normal distribution with an input-dependent mean, and (3) a Gaussian random process with a stationary covariance function. Our results show that incorporating model uncertainty often, but not always, improves the results. If the error in the strain is considered as well, the results improve even more. [less ▲]

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See detailChallenges of water and sanitation service co-production in the global South
Moretto, Luisa; Faldi, Giuseppe; Ranzato, Marco et al

in Environment and Urbanization (in press)

Co-production of water and sanitation services, especially in the global South, implies that recipients of a service play a fundamental role in managing water resources. In the context of ... [more ▼]

Co-production of water and sanitation services, especially in the global South, implies that recipients of a service play a fundamental role in managing water resources. In the context of citizen–government synergies, service recipients are more than consumers, and (co)-production alters their involvement in the service production process, with respect to their relationships with both the natural resources and the delivery process. Our hypothesis is that a meaningful understanding of co- production for water and sanitation services is only possible through an interdisciplinary approach that takes into account natural and social dimensions. The objective is to develop a possible new conceptualization of service co-production that can foster a renewed citizenship while taking into account the risks of urban fragmentation. [less ▲]

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See detailLe syndrome de Klinefelter : actualités cliniques et thérapeutiques
VALDES SOCIN, Hernan Gonzalo ULiege; Rey, R; COPPENS, Luc ULiege et al

in Vaisseaux, Coeur, Poumons (in press), 24(1),

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See detailLes troubles du sommeil chez l'enfant autiste, quel rôle pour le pédopsychiatre?
Abate Ekollo, Joëlle; Malchair, Alain ULiege

in Acta Psychiatrica Belgica (in press)

Les troubles du sommeil sont fréquents chez l’enfant et leurs origines sont diverses. Ces troubles ont leur ancrage dans le développement neurophysiologique et psychoaffectif de l’enfant. Les enfants ... [more ▼]

Les troubles du sommeil sont fréquents chez l’enfant et leurs origines sont diverses. Ces troubles ont leur ancrage dans le développement neurophysiologique et psychoaffectif de l’enfant. Les enfants souffrant de troubles du spectre autistique présentent un déficit de sommeil, qui peut durer jusqu’à l’adolescence. Les troubles du spectre autistique comportent des comorbidités multiples, dont des altérations du sommeil. Ils sont importants à caractériser dans cette population, car ils peuvent avoir un impact négatif sur les comportements diurnes. Par ailleurs, ils entrainent souvent des difficultés au sein de la famille. La prise en charge doit avant tout prendre en compte le contexte environnemental afin d’améliorer les habitudes et l’hygiène du sommeil. Des questionnaires ainsi que des agendas de sommeil ont été remplis par des parents afin de démontrer l’importance d’une évaluation et d’une prise en compte des troubles du sommeil chez les enfants souffrant d’autisme en consultation pédopsychiatrique. [less ▲]

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See detailMood Disorders Patients Treated in a Day Hospital: Focus on Changes in Alexithymia and Openness to Emotions
Triffaux, Jean-Marc ULiege; Nasello, Julian ULiege; Servais, Catherine et al

in Clinical Psychiatry (in press)

Alexithymia and Openness to Emotions (OE) are strongly linked to mood disorders. Alexithymia represents the difficulty of giving words to emotions, whilst OE refers to cognitive representation ... [more ▼]

Alexithymia and Openness to Emotions (OE) are strongly linked to mood disorders. Alexithymia represents the difficulty of giving words to emotions, whilst OE refers to cognitive representation, communication and regulation aspects of emotions. We investigated variables impacting both alexithymia and OE for mood disorder patients (N = 73), before and after a treatment period in a day psychiatric hospital. Significant score changes and, notably, significant impacts of perceived social support were expected. [less ▲]

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See detailArrêts sur images – usages et pratiques du photogramme
Thonon, Jonathan ULiege

in MethIS: Méthodes et Interdisciplinarité en Sciences Humaines (in press)

Le photogramme est, au cinéma, la plus petite unité de prise de vue. Image fixe, unité élémentaire du film, le photogramme forme la cellule figée d’un mouvement qui se reconstitue sous l’effet d’un ... [more ▼]

Le photogramme est, au cinéma, la plus petite unité de prise de vue. Image fixe, unité élémentaire du film, le photogramme forme la cellule figée d’un mouvement qui se reconstitue sous l’effet d’un défilement réglé (24 photogrammes/seconde) par le dispositif technique du cinéma. Image paradoxale en ce qu’elle reste invisible au spectateur malgré sa force iconique, le photogramme trouve cependant, dans le flux qui le conduit insensiblement à la disparition, certaines zones de visibilité qui en révèlent le caractère à la fois fragile et intensif. Nous allons donc envisager certaines pratiques ou certains usages du photogramme cinématographique, tout en essayant de dégager, au départ de ces pratiques, les éléments d’une théorie du photogramme, que Roland Barthes et Sylvie Pierre appelaient déjà de leurs vœux. Des protos-photogrammes et de leur usage scientifique chez Muybridge et Marey, aux usages artistiques contemporains, en passant par des pratiques publicitaires, promotionnelles ou analytiques, nous allons voir que le photogramme reste un objet singulier. [less ▲]

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See detailEnfermement carcéral, imaginaire et pathologie de l’adaptation
Englebert, Jérôme ULiege

in Empan (in press)

Cet article interroge le sort réservé à l’imaginaire dans l’univers carcéral. Une étude minutieuse de ce phénomène fournit des informations sur la psychologie intime de l’homme incarcéré (ses rapports au ... [more ▼]

Cet article interroge le sort réservé à l’imaginaire dans l’univers carcéral. Une étude minutieuse de ce phénomène fournit des informations sur la psychologie intime de l’homme incarcéré (ses rapports au rêve, au corps, à l’altérité, à l’espace et au temps). Ponctuée par une situation clinique, l’étude identifie ce que Sami-Ali appelle le banal (monde hyper-réel duquel les possibilités d’émancipation par l’imaginaire sont réduites, voire inexistantes) comme étant la dynamique de fond du vécu carcéral. L’individu y devient un « être unique en général », rouage anonyme d’une organisation qui le dépasse. [less ▲]

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See detailPoor Vitamin K Status Is Associated With Low Bone Mineral Density and Increased Fracture Risk in End-Stage Renal Disease.
Evenepoel, Pieter; Claes, Kathleen; Meijers, Bjorn et al

in Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research (in press)

Chronic kidney disease and osteoporosis are major public health problems associated with an aging population. Vitamin K insufficiency is prevalent among patients with end-stage renal disease (ESRD ... [more ▼]

Chronic kidney disease and osteoporosis are major public health problems associated with an aging population. Vitamin K insufficiency is prevalent among patients with end-stage renal disease (ESRD). Preliminary data indicate that poor vitamin K status may compromise bone health and that increased inflammation may be in the causal pathway. We performed an ancillary analysis of data collected in the frame of prospective observational cohort studies exploring various aspects of bone health in de novo renal transplant recipients to investigate the association between vitamin K status, inflammation, bone mineral density, and incident clinical fractures. Parameters of mineral metabolism (including biointact PTH and FGF23, sclerostin, calcidiol, calcitriol) and inflammation (CRP and IL-6), osteoprotegerin, bone turnover markers (P1NP, BsAP, and TRAP5B), and dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP) were assessed on blood samples collected immediately prior to kidney transplantation in 468 patients. Areal bone mineral density (aBMD) was measured at the lumbar spine and femoral neck by dual-energy X-ray absorptiometry within 14 days posttransplant. Poor vitamin K status, defined by dp-ucMGP >500 nmol/L, was highly prevalent (90%). High dp-ucMGP levels independently associated with elevated inflammatory markers and low aBMD. No associations were observed between vitamin K status and bone turnover markers. During a median follow-up of 5.1 years, 33 patients sustained a fragility fracture. In Cox-proportional hazards analysis, a dp-ucMGP above median associated with incident fractures, independent of classical determinants, including age, gender, history of fracture, and aBMD (HR 2.21; 95% CI, 1.00 to 4.91; p < 0.05). In conclusion, poor vitamin K status associates with inflammation and low aBMD in patients with ESRD and confers an increased risk of incident fractures in de novo renal transplant recipients. (c) 2018 American Society for Bone and Mineral Research. [less ▲]

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See detailUnderstanding osteoporotic pain and its pharmacological treatment: supplementary presentation
Vellucci, R; Terenzi, R; Kanis, J.A. et al

in Osteoporosis International (in press)

Osteoporosis, a disorder that affects millions of people worldwide, is characterized by decreased bone mass and microstructural alterations giving rise to an increased risk of fractures. Osteoporotic ... [more ▼]

Osteoporosis, a disorder that affects millions of people worldwide, is characterized by decreased bone mass and microstructural alterations giving rise to an increased risk of fractures. Osteoporotic fractures can cause acute and chronic nociceptive and neuropathic pain that mainly affects elderly patients with multiple comorbidities and commonly on different drug regimens. Central sensitization seems to play a pivotal role in developing and maintaining chronicity of post-fracture pain in osteoporosis. Antiosteoporosis drugs are able to partially control pain, but additional analgesics are always necessary for pain due to bone fractures. Nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors reduce acute pain but with a poor effect on the chronic neuropathic component of pain and with relevant side effects. Opioid drugs can control the whole spectrum of acute and chronic bone pain, but they differ with respect to their efficacy on neuropathic components, their tolerability and safety. Chronic pain after osteoporotic fractures requires a multifaceted approach, which includes a large spectrum of drugs (antiosteoporosis treatment, acetaminophen, NSAIDs, selective COX-2 inhibitors, weak and strong opioids) and non-pharmacological treatment. Based on a better understanding of the pathogenesis of osteoporotic and post-fracture pain, a guided stepwise approach to post-fracture osteoporotic pain will also better meet the needs of these patients. [less ▲]

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See detailComplications of paediatric parenteral nutrition
Decsi, T; Hartman, C; Simchowitz, V et al

in Clinical Nutrition (in press)

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See detail"'Vive la rose' in Newfoundland: from Alien to Emblem'
Peere, Isabelle ULiege

in B·A·S·I·S: Ballads and Songs - International Studies (in press)

This paper traces the song in European tradition through to its ‘revival’ in the 1960s. It analyses Emile’ Benoît's textual and musical recreation of it in the light of my own and other fieldworkers’ ... [more ▼]

This paper traces the song in European tradition through to its ‘revival’ in the 1960s. It analyses Emile’ Benoît's textual and musical recreation of it in the light of my own and other fieldworkers’ accounts of his personality, ethos and creative talent in tradition. The study traces the song's course and progress in Newfoundland, following in the steps of French-Canadian ethno-historian Ronald Labelle’s suggestion that ‘Vive la Rose’ has come to function as identity emblem for Newfoundland’s francophone minority – and even as its representative throughout French-Canada and especially Acadia. [less ▲]

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See detailOtro poeta en Nueva York. Gilberto Owen en Los ingrávidos (2011) de Valeria Luiselli
Vanden Berghe, Kristine ULiege; Licata, Nicolas ULiege

in Literatura Mexicana (in press), 31(enero-junio),

In the first novel written by Valeria Luiselli, Los ingrávidos (2011, translation in English: Faces in the crowd), the prominence of Gilberto Owen as a character indicates that Luiselli wishes to give a ... [more ▼]

In the first novel written by Valeria Luiselli, Los ingrávidos (2011, translation in English: Faces in the crowd), the prominence of Gilberto Owen as a character indicates that Luiselli wishes to give a renewed visibility to this Mexican artist and, at the same time, to create a self-image that legitimates her activity as a writer. Disarticulated content, continuous intertextuality and recurring metaliterary reflection, various of the commonalities which link up Luiselli’s poetic practice with that of Owen suggest that she vindicates a literary relationship that situates her in a family of Mexican vanguard writers. This filiation is even more explicit in the novel, because Luiselli turns Owen into a literary character (not without exaggerating some of the poet’s traits that are often associated with the figure of the artist, such as alcoholism or relational failure) and introduces him as her own double. [less ▲]

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See detailInvestigating the impact of river floods on travel demand based on an agent-based modeling approach: The case of Liège, Belgium
Saadi, Ismaïl ULiege; El Saeid Mustafa, Ahmed Mohamed ULiege; Teller, Jacques ULiege et al

in Transport Policy (in press)

In Belgium, river floods are among the most frequent natural disasters and they may have important consequences on travel demand. In order to better understand how the travel patterns vary, we propose to ... [more ▼]

In Belgium, river floods are among the most frequent natural disasters and they may have important consequences on travel demand. In order to better understand how the travel patterns vary, we propose to set up a large scale scenario based on MATSim for guarantying an accurate assessment of the impact of river floods on the transportation system. As inputs, the current agent-based model requires a base year population. A synthetic population with respective set of attributes is generated as a key input. Afterwards, agents are assigned activity chains through an activity-based generation process. Finally, the synthetic population and the transportation network are integrated into MATSim. Regarding data, households travel surveys, OD matrix of Belgium have been used to set up the demand. For simulating river floods effects, a steady-state inundation map has been integrated within MATSim. In the current study, five scenarios have been tested where critical links are associated various levels of service, i.e. 10%, 25%, 50%, 75% and 100% (base case scenario). They are systematically compared to the standard scenario to estimate the deviations in terms of traffic patterns and travel times. The results suggest that compared to the standard scenario, the average trip travel time increased by 16.36%, 44.44%, 126.77% and 144.44% with respect to scenarios 75%, 50%, 25% and 10% respectively. Also, the traffic flows have been re-distributed more uniformly across the transportation network. Roads with important traffic volumes are subjected to a decrease of activity on the contrary of roads with low traffic volumes. A very few studies have focused on how river floods affect transportation systems, this paper provided new insights in term of methodology and traffic patterns analysis under disruptions. [less ▲]

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See detailIndications de l'autogreffe dans la sclérose en plaques : recommandations de la Société francophone de greffe de moelle et de thérapie cellulaire (SFGM-TC) en lien avec la Société francophone de la sclérose en plaques
Zephir, H.; Puyade, M.; Gueguen, A. et al

in Bulletin du Cancer (in press)

The Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) organized the 8th allogeneic hematopoietic stem cell transplantation clinical practices harmonization workshop series ... [more ▼]

The Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) organized the 8th allogeneic hematopoietic stem cell transplantation clinical practices harmonization workshop series in September 2017 in Lille, France. In this article we give the indications of autologous stem cell transplantation in multiple sclerosis as well as recommendations regarding post-transplant follow-up of patients under the hospice of the SFGM-TC and the Francophone Society of Multiple Sclerosis. © 2018 [less ▲]

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See detailMicrobiologie d'une identité professionnelle - Une tentative d’artisans semenciers de reconstruire la santé des plantes avec la vie microbienne
Klaedtke, Stéphanie ULiege; Melard, François ULiege; Chable, Véronique et al

in Études Rurales (in press), 202

Studying the case of an association of artisanal seed companies, we elucidate how these actors articulate the management of crop diversity and of plant health. Under the constraint of a Plant Health ... [more ▼]

Studying the case of an association of artisanal seed companies, we elucidate how these actors articulate the management of crop diversity and of plant health. Under the constraint of a Plant Health regulation prohibiting common bean seeds contaminated with a « quarantine disease » on the seed market, these actors defend their approach to plant health, which consists of managing plant diseases as part of the production system. By claiming recognition for their attachments to plant diseases, they also establish and defend their professional identity, beyond maintaining a set of practices. [less ▲]

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See detailComment les chiens travaillent-ils ? Le cas des chiens détecteurs d’explosifs
Orianne, Jean-François ULiege; Lohay, Etienne ULiege

in Revue de l'Institut de Sociologie (in press)

This paper identifies some leads for the sociological analysis of the work of dogs, by taking the example of the explosive detection dogs within a private security company. The authors show that this ... [more ▼]

This paper identifies some leads for the sociological analysis of the work of dogs, by taking the example of the explosive detection dogs within a private security company. The authors show that this organization - like the federal police or the armed forces - makes the dog exists as a quasi-worker, by inserting him into the division of work, giving him a role (the detection of explosives), a specific status (auxiliary safety officer), based on a specific skill (knowledge of the world through the nose) and certified through professional training (followed in pairs). The complementarity of roles between the dog and the handler instituted by the company strongly frames work interactions, intensifies communication within the pair and generates a dynamic of reciprocal influence, under constraint of effectiveness. Anthropocanine working relationships are analyzed in terms of power, which, according to the authors, constitutes a privileged means of interspecies communication in the absence of a common language. [less ▲]

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See detailL’activité éditoriale comme démarche de représentation de la connaissance: l’exemple de la ponctuation médiévale
Mazziotta, Nicolas ULiege

in Diachroniques: Revue de linguistique française diachronique (in press)

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See detailFactors of Variation of Soil Chemical Properties in Metalliferous Ecosystems of Tenke-Fungurume, Katanga, D. R. Congo
Kaya Muyumba, Donato ULiege; Ilunga wa Ilunga, Edouard; Faucon, Michel-Pierre et al

in Tropicultura (in press)

Our study aimed at deepen our understanding of relationships between soil properties and vegetation distribution in metalliferous ecosystems of Tenke-Fungurume in the Democratic Republic of Congo. The ... [more ▼]

Our study aimed at deepen our understanding of relationships between soil properties and vegetation distribution in metalliferous ecosystems of Tenke-Fungurume in the Democratic Republic of Congo. The first question concerned the differences and similarities between soils of the main vegetation units and four variation factors of soil properties were summarized by multivariate analysis. They were all linked to lithology and significantly contributed to explain the distribution of vegetation units. Our result suggest that the variation of soil properties which is observed within the various vegetation units (rocky steppe savanna, sward, and steppe savannas on slope or on Dembo) should partially be attributed to differences of geochemical composition of rocks between sites but the main source of variability is to be found inside each hill. The soil contamination in Cu and Co originates from rock weathering and besides site effect and topographic distribution of the rocks, the variability of soil properties within one vegetation unit may be due to variability of soil parent material and not only to erosion. The second question dealt with the changes of soil properties at small distances. Metric variation was studied from transects between adjacent vegetation units. Our results showed that the abrupt changes of vegetation units which were clearly identified on the field were all truly explained by the variations of one or more properties linked to lithology. The key point being the Cu bioavailability. [less ▲]

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See detailGenetic structure of lake and stream populations in a Pyrenean amphibian (Calotriton asper) reveals evolutionary significant units associated with paedomorphosis
Oromi Farrús, Neus ULiege; Valbuena-Ureña, Emilio; Soler-Membrives, Anna et al

in Journal of Zoological Systematics and Evolutionary Research (in press)

Differences in environmental conditions such as those between lakes and streams can produce phenotypic variation and ultimately promote evolutionary diversification. Some species of newts and salamanders ... [more ▼]

Differences in environmental conditions such as those between lakes and streams can produce phenotypic variation and ultimately promote evolutionary diversification. Some species of newts and salamanders can occupy these habitats and express alternative phenotypes: metamorphs that lose gills at metamorphosis and paedomorphs that retain them at the adult stage. Whereas this process is facultative in some species, it is obligatory in others, thus suggesting that isolation and environmental pressures may have canalized developmental pathways. In this study, we focused our research on the Pyrenean brook newt, Calotriton asper which is present in both lakes and streams, but whose fully aquatic paedomorphic individuals are only present in lakes. We aimed to determine the genetic structure and differentiation of two paedomorphic populations, including their surrounding stream and lake metamorphic populations, to test whether populations of paedomorphs can constitute evolutionary significant units. Although gene flow was identified between lakes and nearby stream populations, there was a low percentage of dispersers, and the paedomorphic populations were genetically differentiated from the populations of metamorphs. It is likely that the studied lakes have offered peculiar conditions that have allowed the development of a paedomorphic phenotype. These populations and phenotypes therefore constitute good models to understand local adaptations. As each of these populations of paedomorphs can be considered evolutionary significant units that cannot be replaced by other nearby populations in case of a population crash, conservation actions should be focused directly on them. [less ▲]

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See detailStein operators for product distributions, with applications
Gaunt, Robert; Mijoule, Guillaume; Swan, Yvik ULiege

in Journal of Mathematical Analysis and Applications (in press)

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See detailCommon Clays of Foumban area (West Cameroon): Variability, Distribution, Characterization and Potential Applications
Nkalih Mefire, Abiba ULiege

in Journal of African Earth Sciences (in press)

Common clay deposits from five localities in Foumban (West Cameroon) were investigated for their morphological, mineralogical and geochemical properties to determine their potential source rocks and ... [more ▼]

Common clay deposits from five localities in Foumban (West Cameroon) were investigated for their morphological, mineralogical and geochemical properties to determine their potential source rocks and suitability in ceramic product. The analytical results were obtained by X-ray diffraction, X-ray fluorescence spectrometry, Thermogravimetric Analysis, Scanning Electron Microscopy, and Fourier Transform Infrared Spectrometry. Morphologically, an homogeneous clayey layer was found in the upper part of a laterite cover on interfluves, and a clayey heterogeneous hydromorphic material in valleys. They are minerallogically composed of kaolinite (25-84%), illite (0-18%), smectite (0- 31%), and chlorite (0-8 %), associated with quartz (2-44 %), K-feldspars (0-27 %.), plagioclase (0-26%), goethite; (0-9%) with traces of rutile and hematite (≤5 %). The geochemical analysis shows a 115 relative large amount of SiO2 (45-71%), Al2O3 (14-31%), and low Fe2O3 (up to 11 %) suggesting weathering of mainly granitic and rhyolitic parent rocks. Most studied clays could be applied to building ceramic product such as bricks (refractory or not) and tiles. Illite may promote the glassy phase responsible for the densification of the final product. In addition, the relatively high proportion of alkali elements (K2O + Na2O, 6-8%) in some samples from Marom, Koutaba and is responsible for low firing temperature. However the presence of smectite (up to 5 %) limits the application of some Koutaba and Marom clays for ceramic building. The high Fe2O3 contents (> 8 %) in some Bangourain clays implied some pretreatment. [less ▲]

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See detailP.Tebt. 526v: A Land Registry from Tebtunis
Nocchi Macedo, Gabriel ULiege; Gilbert, Nathan

in Bulletin of the American Society of Papyrologists (in press)

Edition of a Greek land registry from Tebtunis

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See detailExecutive summary of European guidance for the diagnosis and management of osteoporosis in postmenopausal women.
Kanis, J.A.; Cooper, C.; Rizzoli, R. et al

in Aging Clinical and Experimental Research (in press)

A guidance on the assessment and treatment of postmenopausal women at risk from fractures due to osteoporosis was recently published in Osteoporosis International as a joint effort of the International ... [more ▼]

A guidance on the assessment and treatment of postmenopausal women at risk from fractures due to osteoporosis was recently published in Osteoporosis International as a joint effort of the International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (Kanis et al. Osteoporos Int, https ://doi.org/10.1007/ s0019 8-018-4704-5, 2018). This manuscript updates the previous guideline document, published in 2013 (Kanis et al. Osteoporos Int 24:23–57, 2013) and is written from a European perspective. The present article reports and summarizes the main recommendations included in this 2018 guidance document (Fig. 1). [less ▲]

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See detailA threesome is healthier than a love triangle: connecting planetary health, climate change and migration
Schütte, Stefanie; Gemenne, François ULiege; Depoux, Anneliese et al

in The Lancet Planetary Health (in press)

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See detailFormes narratives et jugement : réflexions sur l'identité dans l'espace médiatique
Servais, Christine ULiege

in Sociologie (in press)

L’auteure s’attache dans cet article à définir plusieurs formes d’apparitions publiques de l’identité en les mettant en relation avec le jugement. L’hypothèse qui est défendue est que les événements ... [more ▼]

L’auteure s’attache dans cet article à définir plusieurs formes d’apparitions publiques de l’identité en les mettant en relation avec le jugement. L’hypothèse qui est défendue est que les événements racontés dans un « récit de soi » (qu’il soit ou non à la première personne) le sont dans le cadre d’une relation d’interpellations réciproques. Cette relation façonne l’identité et lui donne forme, en même temps qu’elle appelle le public à en répondre de différentes manières, et appelle par conséquent différentes formes de jugements publics. Sont ainsi distingués le drame, la narration, la récitation et le récit. Ce lien entre identité et jugement est illustré par des exemples puisés dans la presse écrite puis par l’analyse d’une une vidéo youtube [less ▲]

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See detailOrganisational aspects of paediatric parenteral nutrition
Puntis, J; Hojsak, I; Ksiazyk, J et al

in Clinical Nutrition (in press)

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See detailWheels for people with disabilities in the post-apartheid city
Schnitzler, Marie ULiege

in Africa (in press)

This article focuses on technologies of mobility for people with physical disabilities living in a South African poor urban setting. It moves away from a perspective that exposes limitations to underline ... [more ▼]

This article focuses on technologies of mobility for people with physical disabilities living in a South African poor urban setting. It moves away from a perspective that exposes limitations to underline specific opportunities for people with disabilities to design the city. In the township of Mitchell’s Plain (Cape Town), known for its violence, defining when and where to use the chair involves a negotiation of moral and medical norms with a pursuit of security. In this process, the wheelchair constitutes one element of a larger continuum of wheeled mobility. The availability of public and private alternative transport enhances already present inequalities among people with disabilities. Two systems of public transport are further discussed, namely Dial-a-Ride (a specialized transport) and MyCiTi bus (a mainstream service). Initiatives of the City of Cape Town, these transports are widely discussed and criticized by people with disabilities. Through discussion with or opposition to the local government, associations participate actively in their inclusion in the post-apartheid city. My conclusions, drawn upon nineteen months of ethnographic fieldwork, call upon the theoretical framework of the anthropology of material things and the sociology of space. [less ▲]

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See detailEnjeux politiques et critiques d'une philosophie des normes
Caeymaex, Florence ULiege; Pieron, Julien ULiege

in Dissensus (in press)

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See detailHealth and fitness online communities and product behaviour
Dessart, Laurence ULiege; Duclou, Maureen

in Journal of Product and Brand Management (in press)

This study seeks to determine the impact of participating in health and fitness community on social media on individual’s health attitudes and health and fitness product-related behaviour. Survey data are ... [more ▼]

This study seeks to determine the impact of participating in health and fitness community on social media on individual’s health attitudes and health and fitness product-related behaviour. Survey data are collected from 221 users of the social medium Instagram, members of the self-proclaimed health and fitness community (#fitfam) and analysed with structural equation modelling. The study shows that community identification and engagement significantly contribute to increasing health environment sensitivity, resulting in heightened engagement in physical fitness and healthy product choices. Given the difficulty to remain engaged in pro-health behaviour and the growing impact of social media on young adult’s lives, these findings are encouraging. They show that online health and fitness communities provide a supportive environment in which consumers can identify and freely engage, and a fertile ground to the development of health sensitivity and product-related behaviour. The study contributes to health product promotion and advances the role of social media and online communities in this process. [less ▲]

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See detailA Cross-national investigation of Hallucination Like-Experiences in 10 countries: The E-CLECTIC study.
Siddi, S; Ocha, S; Laroi, Frank ULiege et al

in Schizophrenia Bulletin (in press)

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See detailFluid and Electrolytes (Na, Cl and K) in Paediatric Parenteral Nutrition
Jochum, Franck; Moltu, Sissel; SENTERRE, Thibault ULiege et al

in Clinical Nutrition (in press)

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See detailBuilding kidney exchange programmes in Europe: an overview of exchange practice and activities
Biro, Peter; Haase-Kromwijk, Bernadette; Andersson, Tommy et al

in Transplantation (in press)

BACKGROUND:Considerable differences exist among the living donor Kidney Exchange Programmes (KEPs) that are in use and being built in Europe, contributing to a variation in the number of living donor ... [more ▼]

BACKGROUND:Considerable differences exist among the living donor Kidney Exchange Programmes (KEPs) that are in use and being built in Europe, contributing to a variation in the number of living donor transplants [6]. Efforts of European KEPs to exchange (best) practices and share approaches to address challenges have, however, been limited.METHODS:Experts from 23 European countries, collaborating on the ENCKEP COST Action, developed a questionnaire to collect detailed information on the functioning of all existing KEPs in Europe, as well as their opportunities and challenges. Following a comparative analysis, results were synthesised and interpreted by the same experts.RESULTS:The practices, opportunities and challenges reported by 17 European countries reveal that some of the 10 operating programmes are mature, while others are in earlier stages of development. Over 1300 transplants were performed through existing KEPs up to the end of 2016, providing approximately 8\% of their countries' living kidney donations in 2015. All countries report challenges to either initiating KEPs or increasing volumes. Some challenges are shared, whilst others differ because of differences in context (eg, country size, effectiveness of deceased donor programme) and ethical and legal considerations (eg, regarding living donation as such, nonrelated donors, and altruistic donation). Transnational initiatives have started in Central Europe, Scandinavia, and Southern Europe.CONCLUSIONS:Exchange of best practices and shared advancement of national programmes to address existing challenges, aided by transnational exchanges, may substantially improve access to the most (cost) effective treatment for the increasing number of patients suffering from kidney disease.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. [less ▲]

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