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See detailEquivalence des hypothèses et relativité du mouvement dans la Dynamica
Bouquiaux, Laurence ULiege

in Studia Leibnitiana (in press)

Leibniz’s conception of the relativity of motion has been discussed at length for a very long time. This paper doesn’t aim to give a full solution to this question, but to contribute to the debate by ... [more ▼]

Leibniz’s conception of the relativity of motion has been discussed at length for a very long time. This paper doesn’t aim to give a full solution to this question, but to contribute to the debate by clarifying how the principle of relativity is introduced, justified and used in the Dynamica. Four different principles are identified : one purely geometrical, and three (meta)physical principles, which express God’s wisdom : a principle of equivalence of hypotheses linked to the action/reaction principle, a galilean principle of relativity and a general principle which apply not only to rectilinear motions but also to circular ones. I argue that to appreciate the coherence of Leibniz’ approach, we should distinguish these principles more sharply than he himself did and pay more attention to their status : are they consequences of the definition of motion, consequences of the physical laws or necessary conditions for any physical theory ? [less ▲]

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See detailRisk assessment of Tunisian consumers and farm workers exposed to residues after pesticide application in chili peppers and tomatoes
Toumi, Khaoula ULiege; Joly, Laure; Tarchoun, Neji et al

in Tunisian Journal of Plant Protection (in press)

In Tunisia, to prevent and control pests and diseases during cultivation under greenhouses, chili pepper and tomato require the use of a wide range of pesticides potentially toxic and thus presenting a ... [more ▼]

In Tunisia, to prevent and control pests and diseases during cultivation under greenhouses, chili pepper and tomato require the use of a wide range of pesticides potentially toxic and thus presenting a possible risk for farm operators, workers or consumers. A study has been carried out in the Sahel region of Tunisia to assess the risk for farm operators and workers exposed, by contact during harvest tasks, to possible pesticide residues remaining in tomato and chili pepper cultures, and for the Tunisian consumers (adults and children) after intake. A questionnaire was addressed to a group of 73 market gardeners to better understand the local professional practices and to determine the main route of exposure to pesticide. Twenty samples of cotton gloves (2 pairs / sample) were distributed to 20 volunteers who worn them for two consecutive half-days during the harvest of chili peppers or tomatoes before analysis of the dislodgeable pesticide residues which could be transferred from crops to hands. Using models predictive exposures values were calculated for consumers and farm workers. The highest exposure of consumers was observed for chlorpyrifos residues on tomatoes (with 82% and 312% of the Acute Reference Dose (ARfD), for adults and children respectively). The systemic exposure (SE) of farm workers was estimated for the average, the 90th percentile and the maximum concentration. At the highest observed concentrations, 15 pesticide residues (active substance and metabolites) used in pepper greenhouses, and 9 in tomato crops, exceed the Acceptable Operator Exposure Level (AOEL). Exposure appeared to be particularly critical for chlorothalonil sprayed in chili pepper greenhouses with SEMAX values 113 times higher than the AOEL (11285%). Long task duration (8 hours/day) after re-entry in greenhouse, limited access to personal protective equipment (PPE), lack of hygiene and bad habits (eating, drinking, or smoking at work) have also been observed and discussed as risk factors. [less ▲]

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See detailCapillary electrophoresis-mass spectrometry of derivatized amino acids for targeted neurometabolomics – pH mediated reversal of diastereomer migration order
Moldovan, Radu-Cristian ULiege; Bodoki, Ede; Servais, Anne-Catherine ULiege et al

in Journal of Chromatography. A (in press)

A targeted CE-MS approach was developed for the chiral analysis of biologically relevant amino acids in artificial cerebrospinal fluid (aCSF). In order to achieve chiral resolution, the five amino acids ... [more ▼]

A targeted CE-MS approach was developed for the chiral analysis of biologically relevant amino acids in artificial cerebrospinal fluid (aCSF). In order to achieve chiral resolution, the five amino acids (Ser, Asn, Asp, Gln and Glu) were derivatized with (+)-1-(9-fluorenyl)ethyl chloroformate ((+)-FLEC). The diastereoselectivity was found to be highly dependent on pH for all analytes and the optimized background electrolyte (BGE) consisted of 150 mM acetic acid, adjusted to pH 3.7 with NH4OH. Furthermore, a reversal of the migration order of Asp derivatives was observed. This phenomenon seems to be caused by intra-molecular interactions affecting the pKa of the second ionizable group (the side chain carboxyl). The applicability of this method was evaluated using aCSF. A solid phase extraction (SPE) protocol was developed for the selective extraction of the FLEC derivatives. A full evaluation of the matrix effect and extraction yield was performed concluding that the matrix effect is marginal and the recoveries are between 46 and 92%. The method offers adequate sensitivity (limits of detection below 1 μM). [less ▲]

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See detailProtein folding at extreme temperatures: current issues
Feller, Georges ULiege

in Seminars in Cell & Developmental Biology (in press)

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See detailContribution à un lexique épigraphique: "deltographéma"
Famerie, Etienne ULiege

in Zeitschrift für Papyrologie und Epigraphik (in press)

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See detailModelling of short-term interactions between concrete support and the excavated damage zone around galleries drilled in Callovo-Oxfordian claystone
Argilaga, Albert ULiege; Collin, Frédéric ULiege; Lacarrière, Laurie et al

in International Journal of Civil Engineering (in press)

Production of energy from nuclear power plants generates high-level radioactive nuclear waste, harmful during dozens of thousand years. Deep geological disposal of nuclear waste represents the most ... [more ▼]

Production of energy from nuclear power plants generates high-level radioactive nuclear waste, harmful during dozens of thousand years. Deep geological disposal of nuclear waste represents the most reliable solutions for its safe isolation. Confinement of radioactive wastes relies on the multi-barrier concept in which isolation is provided by a series of engineered (canister, backfill) and natural (host rock) barriers. Few underground research laboratories have been built all over the world to test and validate storage solutions. The underground drilling process of disposal drifts may generate cracks, fractures/strain localisation in shear bands within the rock surrounding the gallery especially in argillaceous rocks. These degradations affect the hydro-mechanical properties of the material, such as permeability, e.g. creating a preferential flow path for radionuclide migration. Hydraulic conductivity increase within this zone must remain limited to preserve the natural barrier. In addition galleries are currently reinforced by different types of concrete supports such as shotcrete and/or prefab elements. Their purpose is twofold: avoiding partial collapse of the tunnel during drilling operations and limiting convergence of the surrounding rock. Properties of both concrete and rock mass are time dependent, due to shotcrete hydration and hydromechanical couplings within the host rock. By the use of a hydro-mechanical coupled Finite Element Code with a Second Gradient regularization, this paper aims at investigating and predicting support and rock interactions (convergence, stress field). The effect of shotcrete hydration evolution, spraying time and use of compressible wedges is studied in order to determine their relative influence. [less ▲]

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See detailThe Distribution of Spanish Books in Brussels during the 16th century
Adam, Renaud ULiege

in Quaerendo: A Journal Devoted to Manuscripts and Printed Books (in press)

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See detailL'espace transitionnel winnicotien et l'_Urraum_ kantien
Seba, Jean-Renaud ULiege

in Revista Natureza Humana (in press)

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See detailLa Vigna Manzi a Garaguso (MT) : Vecchi scavi, ricerche in corso e prospettive di studio di un importante sito indigeno
Cuvelier, Graham ULiege; Morard, Thomas ULiege; Motta, Lucie

in Siris : Studi e Ticerche della Scuola di Specializzazione in Archeologia di Matera (in press)

This article traces the history of the archaeological research conducted on the site of the Vigna Manzi in Garaguso starting from the excavation of Vittorio Di Cicco in 1916 (which uncovered the famous ... [more ▼]

This article traces the history of the archaeological research conducted on the site of the Vigna Manzi in Garaguso starting from the excavation of Vittorio Di Cicco in 1916 (which uncovered the famous “Dea di Garaguso” and her tempietto) to the five surveys run by Jean-Paul Morel between 1969 and 1970. It then presents the results of the campaign led by Jean-Marc Moret in 2008 as well as the reopening and the prospects of the study of this site by the University of Liège. [less ▲]

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See detailUsing a penalty term to deal with spurious oscillations in second gradient finite elements
Soufflet, Marc; Jouan, Gwendal; Kotronis, Panagiotis et al

in International Journal of Damage Mechanics (in press)

It is well known that it is necessary to introduce a length scale parameter in a continuum damage mechanics model to correctly simulate strain localization. The second gradient model, a special case of ... [more ▼]

It is well known that it is necessary to introduce a length scale parameter in a continuum damage mechanics model to correctly simulate strain localization. The second gradient model, a special case of kinematically enriched continua, considers an internal length parameter by taking into account the second order derivatives of the displacements in the virtual power principle. In this paper, we show that the original second gradient finite element of Chambon and co-workers can present spurious oscillations, especially for mode I crack propagation problems. After providing the plane stress second gradient constitutive law, we propose to add a penalty term in the original formulation in order to improve numerical convergence and to avoid spurious oscillations in the local variables distributions. Two numerical examples using classical damage mechanics laws, a three points reinforced concrete beam and a trapezoidal notched specimen are used to test the performance of the formulation. Parametrical studies are also shown on the influence of the penalty parameter. The problem of unrealistic damage spreading for damage values close to one, occurring often in mode I crack propagation problems, is finally discussed. [less ▲]

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See detailTrade in Environmental Goods: Evidences from an Analysis Using Elasticities of Trade Costs
Sorgho, Zakaria ULiege; Tamini, Lota

in Environmental & Resource Economics (in press)

Negotiations on the liberalization of environmental goods (EGs) and services within the WTO Doha Round (mandated in November 2001) are facing specific challenges. Conflicting interests and differing ... [more ▼]

Negotiations on the liberalization of environmental goods (EGs) and services within the WTO Doha Round (mandated in November 2001) are facing specific challenges. Conflicting interests and differing perceptions of the benefits of increased trade in EGs were reflected in different approaches proposed for determining EGs. Using import data of 34 Organisation for Economic Co-operation and Development (OECD) member countries and from a sample of 167 countries, from 1995 to 2012, we discuss the trade effect of reducing barriers on EGs. We analyze the lists of EGs proposed by the Asia-Pacific Economic Cooperation and OECD using a Translog gravity model. We found that removing tariff barriers for EGs will have a modest impact because for the biggest importers and exporters, elasticities of trade costs are very low while for most trading relationships they are very high, making it difficult for exporters to maintain their markets. Overall, our results suggest that, because of their substantial effect on international trade, future negotiations on EGs should also address the issues of standards and nontariff barriers. [less ▲]

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See detailThe long-period massive binary HD 54662 revisited
Mossoux, Enmanuelle ULiege; Mahy, Laurent ULiege; Rauw, Grégor ULiege

in Astronomy and Astrophysics (in press)

Context. HD 54662 is an O-type binary star belonging to the CMa OB1 association. Because of its long-period orbit, this system is an interesting target to test the adiabatic wind shock model. Aims. The ... [more ▼]

Context. HD 54662 is an O-type binary star belonging to the CMa OB1 association. Because of its long-period orbit, this system is an interesting target to test the adiabatic wind shock model. Aims. The goal of this study is to improve our knowledge of the orbital and stellar parameters of HD 54662 and to analyze its X-ray emission to test the theoretical scaling of X-ray emission with orbital separation for adiabatic wind shocks. Methods. We applied a spectral disentangling code to a set of optical spectra to determine the radial velocities and the individual spectra of the primary and secondary stars. The orbital solution of the system was established and the reconstructed individual spectra were analyzed by means of the CMFGEN model atmosphere code. We fitted two X-ray spectra using a Markov Chain Monte Carlo algorithm and compared these spectra to the emission expected from adiabatic shocks. Results. We determine an orbital period of 2103.4 days, a surprisingly low orbital eccentricity of 0.11, and a mass ratio m2/m1 of 0.84. Combined with the orbital inclination inferred in a previous astrometric study, we obtain surprisingly low masses of 9.7 and 8.2 Msun. From the disentangled primary and secondary spectra, we infer O6.5 spectral types for both stars, of which the primary is about two times brighter than the secondary. The softness of the X-ray spectra for the two observations, the very small variation of best-fitting spectral parameters, and the comparison of the X-ray-to-bolometric luminosity ratio with the canonical value for O-type stars allow us to conclude that X-ray emission from the wind interaction region is quite low and that the observed emission is rather dominated by the intrinsic emission from the stars. We cannot confirm the runaway status previously attributed to HD 54662 by computing the peculiar radial and tangential velocities. We find no X-ray emission associated with the bow shock detected in the infrared. Conclusions. The lack of hard X-ray emission from the wind-shock region suggests that the mass-loss rates are lower than expected and/or that the pre-shock wind velocities are much lower than the terminal wind velocities. The bow shock associated with HD 54662 possibly corresponds to a wind-blown arc created by the interaction of the stellar winds with the ionized gas of the CMa OB1 association rather than by a large differential velocity between the binary and the surrounding interstellar medium. [less ▲]

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See detailVers la fin de la gestion des carrières ? La GRH face au rôle croissant des intermédiaires du marché du travail
Pichault, François ULiege; Lorquet, Nadège ULiege; Orianne, Jean-François ULiege

in Relations Industrielles (in press)

The HRM literature has been discussing for some time the evolutions observed in the field of careers, opposing the conventional model of organizational careers with emerging boundaryless careers ... [more ▼]

The HRM literature has been discussing for some time the evolutions observed in the field of careers, opposing the conventional model of organizational careers with emerging boundaryless careers, reflecting a new psychological contract between workers and organizations at the beginning of the 21st century. In this context, HR managers must attract new talent, while knowing that their involvement in the organization will be limited in time. The unprecedented development of project-based work, which falls midway between employee and self-employed status, seems to reinforce this « modern » vision of careers. However, an in-depth observation of the current labour market evolution shows that careers of project-based workers do not only result from individual initiatives of workers offering their talents on the market. These workers often use intermediation structures that become essential partners of the management of career paths via a full range of supporting devices. Through conceptual work on the notion of labour market intermediaries and multiple contrasted case studies focusing on the Belgian labour market, our paper illustrates the diversity of forms taken by this intermediation process. It also emphasizes two ideal-types reflecting opposite views on the way professional transitions can be secured: the first one considers project-based workers as « quasi employees »; the second as « quasi self-employed ». We then highlight how this triangular game leads us to question career management as a sovereign power of the HR function. [less ▲]

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See detailHeboidophrenia and pseudopsychopathic schizophrenia: Literature review and critical perspective
De Page, Louis; Englebert, Jérôme ULiege

in Psychopathology (in press)

In this article, based on extensive literature review, we present an integrated description of heboidophrenia and pseudo-psychopathic schizophrenia. Both diagnostic constructs describe latent psychotic ... [more ▼]

In this article, based on extensive literature review, we present an integrated description of heboidophrenia and pseudo-psychopathic schizophrenia. Both diagnostic constructs describe latent psychotic processes inextricably bound with psychopathic features. Although both syndromes have been described in different eras and research threads, they are that similar that we could not find divergent characteristics. We formulated operational criteria for clinical and research purpose. The recognition of this syndrome improves risk management, treatment and legal decisions. [less ▲]

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See detailL’hôpital de jour ou la métaphore des essuie-glaces…
RATY, Nicolas ULiege; Leruth, Véronique; Gelaesen, Marine et al

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (in press)

In Belgium, in the era of « evidence based psychiatry », mental health care is on the cusp of a major reform related to the Hospital Act ("art.107"). But care for people with psychic disorders does not ... [more ▼]

In Belgium, in the era of « evidence based psychiatry », mental health care is on the cusp of a major reform related to the Hospital Act ("art.107"). But care for people with psychic disorders does not lend itself to therapeutic rules based on « evidence ». Despite this antinomy, the field of psychiatry is confronted with the budgetary res-trictions imposed by health care policies. As well as other somatic pathologies, psychiatry does not escape the process of « human body » and medicine in general, commercialization. The day hospital, because of its polymorphism and its innovative character, has always been able to adapt to various societal crisis so far as to become, for some, a « day hospital 2.0 ». Its current evolution deviates far from the initial models devised by the pioneers of institutional therapy. The creation of a new link between hospital and home is one of the innovative aspects of this reform. The introduction of mobile teams and the development of home care should help to treat psychiatric patients who would never have gone out for help and care, whether in-hospital or as an outpatient. Support of the existing links with the entourage and communication between the different partners of the network should thus be reinforced. After a historical reminder about the evolutions of psychiatry and of the legal reforms related to the mode of operation of day hospitals, we will develop the singular aspect and the specificity of our Day Hospital, « La Clé ». As an avant-garde structure, our care protocol immediately assumed that group psychotherapy effectively supplements individual psychotherapy and psychosocial rehabilitation. Institutional therapy, adapted on a part-time basis, significantly reduces the risk of chronicity and mass regression while stimulating the psychic progress of the individual in a benevolent community setting. A good metaphor for the concept of day hospital could be « windshield wipers » : through changes that may get stormy, they do not stop the rain but they allow to move forward ... [less ▲]

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See detailIPCAPS: an R package for iterative pruning to capture population structure
Chaichoompu, Kridsadakorn ULiege; Abegaz Yazew, Fentaw; Tongsima, Sissades et al

in Bioinformatics (in press)

Resolving population genetic structure is challenging, especially when dealing with closely related populations. Although Principal Component Analysis (PCA)-based methods and genomic var- iation with ... [more ▼]

Resolving population genetic structure is challenging, especially when dealing with closely related populations. Although Principal Component Analysis (PCA)-based methods and genomic var- iation with single nucleotide polymorphisms (SNPs) are widely used to describe shared genetic an- cestry, improvements can be made targeting fine-level population structure. This work presents an R package called IPCAPS, which uses SNP information for resolving possibly fine-level population structure. The IPCAPS routines are built on the iterative pruning Principal Component Analysis (ipP- CA) framework to systematically assign individuals to genetically similar subgroups. Our tool is able to detect and eliminate outliers in each iteration to avoid misclassification. It can be extended to de- tect subtle subgrouping in patients as well. In addition, IPCAPS supports different measurement scales for variables used to identify substructure. Hence, panels of gene expression and methylation data can be accommodated. [less ▲]

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See detailLa tradition manuscrite de la « Post-Vulgate ». Histoire d’une diaspora textuelle
Morato, Nicola ULiege

in Revue de Linguistique Romane (in press)

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See detailDo metaphors matter? The impact of a metaphor on citizens’ representations and preferences about federalism
Dodeigne, Jérémy ULiege; Perrez, Julien ULiege; Reuchamps

in Regional & Federal Studies (in press)

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See detailSpectral Echoes in Caryl Phillips’s The Nature of Blood
Mascoli, Giulia ULiege

in Lectures du Monde Anglophone (in press)

In A New World Order (2001) Caryl Phillips claims that “every writer discovers that his or her main struggle is with this one world: form” (293). His struggle with form bears on questions such as how to ... [more ▼]

In A New World Order (2001) Caryl Phillips claims that “every writer discovers that his or her main struggle is with this one world: form” (293). His struggle with form bears on questions such as how to write about unbearably painful lives, how to mirror the trauma undergone by his characters, or how to speak about the unspeakable. Phillips seems to have found a stylistic device enabling him to offer the readers a sense of his characters’ traumatic experience and mirror their emotional state: the musicalization of his prose. Phillips’s use of what I call musical writing is striking in his 1997 novel The Nature of Blood, especially in the sections devoted to Eva. This essay offers an interpretation of Phillips’s musical prose through close readings of Eva’s story and explores how the author’s musical stylization can also reflect the two different ways of approaching traumatic experience suggested by Dominick LaCapra’s: “acting out” and “working through” (Writing 21–2, History 54,104). This piece also shows how through stylistic devices akin to music Phillips resorts to a language which both seeks and defies the reader’s understanding, thereby avoiding any easy identification with Eva. [less ▲]

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See detailIllness perceptions explain the variance in functional disability, but not habitual physical activity, in patients with chronic low back pain: A cross-sectional study
Leysen, Marijke; Nijs, Jo; Van Wilgen, Paul et al

in Pain Practice (in press)

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See detailUne conversion contestable de l’usufruit du conjoint survivant (note sous Gand (11e ch.), 19 novembre 2015)
Pottier, Alix ULiege

in Revue Générale de Droit Civil Belge (in press)

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See detailHeliospheric conditions at Saturn during Cassini's Ring-Grazing and Proximal Orbits
Roussos, E.; Krupp, N.; Paranicas, C. et al

in Geophysical Research Letters (in press)

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See detailNew low electron flux facility in the 0 to 3.5 MeV range for the study of induced signal in JUICE instruments: UVS and MAJIS measurements
Carapelle, Alain ULiege; Grodent, Denis ULiege; Langevin, Yves et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (in press)

We designed and built a new test facility to investigate signal induced by electrons in the 0-3.5 MeV in the JUICE UVS and MAJIS instruments. The facility uses radioisotopes sources to produce low flux of ... [more ▼]

We designed and built a new test facility to investigate signal induced by electrons in the 0-3.5 MeV in the JUICE UVS and MAJIS instruments. The facility uses radioisotopes sources to produce low flux of electrons (< 6000 electrons/cm².s). We present the facility, its capabilities and the results of measurements on UVS and MAJIS [less ▲]

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See detailFlow field in shallow reservoir with varying inlet and outlet position
Ferrara, Velia; Erpicum, Sébastien ULiege; Archambeau, Pierre ULiege et al

in Journal of Hydraulic Research (in press)

Shallow reservoirs are used for multiple purposes, such as storm water retention and trapping of sediments. Reliable predictions of the flow fields are necessary to inform the design and operation of ... [more ▼]

Shallow reservoirs are used for multiple purposes, such as storm water retention and trapping of sediments. Reliable predictions of the flow fields are necessary to inform the design and operation of these structures. Using numerical simulations, we performed a systematic analysis of the influence of the location of the inlet and outlet on the flow fields developing in rectangular shallow reservoirs of various sizes. Depending on the relative location of the inlet and outlet with respect to the reservoir centreline, contrasting flow patterns are obtained, involving either no flow reattachment, or a jet reattached on either of the reservoir sidewalls. The results reveal also the occurrence of bi-stable flow configurations, i.e. different steady state flow fields are reached depending on the flow history. This is of high relevance for the design of shallow reservoirs as such configurations should certainly be avoided to achieve a robust hydraulic sizing of the reservoir. [less ▲]

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See detailExercise and education program after breast cancer: benefits on quality of life and symptoms at three, six, twelve and twenty-four months of follow-up
LECLERC, Anne-France ULiege; Slomian, Justine ULiege; JERUSALEM, Guy ULiege et al

in Clinical Breast Cancer (in press)

BACKGROUND: Various clinical trials show benefits of physical training offered during and / or after breast cancer treatments. However, given the variety of side effects that may be encountered, physical ... [more ▼]

BACKGROUND: Various clinical trials show benefits of physical training offered during and / or after breast cancer treatments. However, given the variety of side effects that may be encountered, physical training could be combined with psychological, relational and social guidance. This kind of multidisciplinary program, just like their long-term effects, have been little studied so far. Therefore, the objective of our study is to determine the benefits at 3, 6, 12 and 24 months of a three-month exercise and education program among women after breast cancer treatment. MATERIALS AND METHODS: Two hundred and nine outpatients who have been treated for a primary breast carcinoma were divided into a control group (n=106) and an experimental group (n=103) which has benefited from a three-month rehabilitation program including physical training and psycho-educational sessions. The assessments, performed before the program and at 3, 6, 12 and 24 months after inclusion, included validated questionnaires on quality of life and symptoms. RESULTS: The analyses show an improvement in quality of life and symptoms following the exercise and education program within the experimental group and a maintenance of these improvements during the two years of follow-up. These improvements are significantly superior to those presented in the control group, demonstrating the programs benefits. CONCLUSIONS: This trial identifies the benefits of a well detailed three-month exercise and education program over a follow-up of 24 months among women after breast cancer treatment. [less ▲]

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See detailIn vivo antimalarial and antitrypanosomal activity of strychnogucine B, a bisindole alkaloid from Strychnos icaja.
Beaufays, Claire; Ledoux, Allison ULiege; Jansen, Olivia ULiege et al

in Planta Medica (in press)

Strychnogucine B is a bisindole alkaloid previously isolated from Strychnos icaja that possesses promising in vitro antiplasmodial properties. This compound was synthesized in four steps from (− ... [more ▼]

Strychnogucine B is a bisindole alkaloid previously isolated from Strychnos icaja that possesses promising in vitro antiplasmodial properties. This compound was synthesized in four steps from (−)-strychnine. As no acute toxicity was observed at the highest tested cumulative dose of 60 mg/kg, its in vivo antimalarial activity was determined intraperitoneally at 30mg/kg/d in a Plasmodium berghei murine model. In the Petersʼs 4-d suppressive test, this alkaloid suppressed the parasitaemia by almost 36% on day 5 and 60% on day 7 compared to vehicle-treated mice. In addition to this interesting antimalarial activity, it showed moderate in vitro antitrypanosomal activity but no in vivo activity in an acute Trypanosoma brucei model. It was also inactive in vitro on Leishmania mexicana promastigotes. This highlights its selective antimalarial efficacy and leads to further investigation to assess its potential as new antimalarial lead compound. [less ▲]

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See detailMoral Hazard in High-Risk Environments: Optimal Follow-on Investing in Venture Capital Finance
Tennert, Julius; Lambert, Marie ULiege; Burghof, Hans-Peter

in Venture Capital (in press)

This paper examines the joint effect of environmental risk and moral hazard on staging activity in venture capital financing. We show theoretically and empirically that venture capitalists face a trade ... [more ▼]

This paper examines the joint effect of environmental risk and moral hazard on staging activity in venture capital financing. We show theoretically and empirically that venture capitalists face a trade-off between a) deferring and staging investments to engage in learning of the risky venture and avoid downside losses and b) committing additional funds to update the incentive of the entrepreneur. We describe this trade-off through the timing of follow-on investments and show that highly qualified entrepreneurs demand greater compensation (a larger share) than do less qualified entrepreneurs in situations of high risk. [less ▲]

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See detailBenfotiamine Treatment Activates the Nrf2/ARE Pathway and is Neuroprotective in a Transgenic Mouse Model of Tauopathy
Tapias, Victor; Jainuddin, Shari; Ahuja, Manuj et al

in Human Molecular Genetics (in press)

Impaired glucose metabolism, decreased levels of thiamine and its phosphate esters, and reduced activity of thiamine-dependent enzymes, such as pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase ... [more ▼]

Impaired glucose metabolism, decreased levels of thiamine and its phosphate esters, and reduced activity of thiamine-dependent enzymes, such as pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and transketolase occur in Alzheimer’s disease (AD). Thiamine deficiency exacerbates amyloid beta (Aβ) deposition, tau hyperphosphorylation, and oxidative stress. Benfotiamine (BFT) rescued cognitive deficits and reduced Aβ burden in APP/PS1 mice. In this study, we examined whether BFT confers neuroprotection against tau phosphorylation and the generation of neurofibrillary tangles (NFTs) in the P301S mouse model of tauopathy. Chronic dietary treatment with BFT increased lifespan, improved behavior, reduced glycated tau, decreased NFTs, and prevented death of motor neurons. BFT administration significantly ameliorated mitochondrial dysfunction and attenuated oxidative damage and inflammation. We found that BFT and its metabolites (but not thiamine) trigger the expression of Nrf2/ARE- dependent genes in mouse brain as well as in wild-type but not Nrf2-deficient fibroblasts. Active metabolites were more potent in activating the Nrf2 target genes than the parent molecule BFT. Docking studies showed that BFT and its metabolites (but not thiamine) bind to Keap1 with high affinity. These findings demonstrate that BFT activates the Nrf2/ARE pathway and is a promising therapeutic agent for the treatment of diseases with tau pathology, such as AD, frontotemporal dementia, and progressive supranuclear palsy. [less ▲]

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See detailLes haruspices publics au service de Rome : des aristocrates convoqués d’Étrurie ? Quels aristocrates ?
Berthelet, Yann ULiege

in Dialogues d'Histoire Ancienne (in press)

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See detailA Markov-switching Generalized additive model for compound Poisson processes, with applications to operational losses models
Hambuckers, julien ULiege; Kneib, Thomas; Langrock, Roland et al

in Quantitative Finance (in press)

This paper is concerned with modeling the behavior of random sums over time. Such models are particularly useful to describe the dynamics of operational losses, and to correctly estimate tail-related risk ... [more ▼]

This paper is concerned with modeling the behavior of random sums over time. Such models are particularly useful to describe the dynamics of operational losses, and to correctly estimate tail-related risk indicators. However, time-varying dependence structures make it a difficult task. To tackle these issues, we formulate a new Markov-switching generalized additive compound process combining Poisson and generalized Pareto distributions. This flexible model takes into account two important features: on the one hand, we allow all parameters of the compound loss distribution to depend on economic covariates in a flexible way. On the other hand, we allow this dependence to vary over time, via a hidden state process. A simulation study indicates that, even in the case of a short time series, this model is easily and well estimated with a standard maximum likelihood procedure. Relying on this approach, we analyze a novel dataset of 819 losses resulting from frauds at the Italian bank UniCredit. We show that our model improves the estimation of the total loss distribution over time, compared to standard alternatives. In particular, this model provides estimations of the 99.9% quantile that are never exceeded by the historical total losses, a feature particularly desirable for banking regulators. [less ▲]

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See detailVideo Games in France and Francophone Belgium. Discourses and cultural legitimation
Delbouille, Julie ULiege

in Contemporary French Civilization (in press)

Since its first appearance in the early 1960s, video game has become one of the most popular forms of entertainment in France and francophone Belgium. As for other cultural industries, the last decades ... [more ▼]

Since its first appearance in the early 1960s, video game has become one of the most popular forms of entertainment in France and francophone Belgium. As for other cultural industries, the last decades have seen the emergence of multiple discourses around video game, whether they come from the media, the public or the private sphere. From the themes of violence and addiction to the perception of video game as a cultural object, this paper aims to provide a comprehensive overview of game-related discourses and representations (and their recent evolution) in Francophone Europe. [less ▲]

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See detailLes statuts morphologiques d'urbanisation des communes de Kinshasa en République Démocratique du Congo
Sambieni, K.R.; Messina Ndzomo, J.-P.; Biloso Moyene, A. et al

in Tropicultura (in press)

Cet article met en évidence la forte présence de la périurbanisation à Kinshasa par la caractérisation de son gradient urbain-rural. A partir de l’observation de la morphologie d’urbanisation sur Google ... [more ▼]

Cet article met en évidence la forte présence de la périurbanisation à Kinshasa par la caractérisation de son gradient urbain-rural. A partir de l’observation de la morphologie d’urbanisation sur Google Earth de 34035 mailles carrées de 25 ha chacune, couvrant toute l’étendue de la ville, nous avons réalisé une typologie de ses communes suivant le gradient urbain-rural. Nous avons également étudié l’évolution de la densité de population des différentes zones identifiées. Les résultats renseignent que Kinshasa compte actuellement 15 communes à statut urbain, 4 à statut périurbain et 5 à statut rural. La superficie cumulée des zones périurbaines et rurales représente plus de 96 % de la superficie totale de la ville démontrant le fort potentiel du phénomène de périurbanisation. Nous observons par ailleurs, une tendance de densification dans toutes les zones du gradient urbain-rural avec une situation densimétrique intermédiaire en zone périurbaine. Cette étude offre des données et un cadre théorique pour alimenter des études d’impacts environnementaux à propos de l’urbanisation et pour orienter la planification et l’aménagement des espaces périurbains et ruraux à Kinshasa. [less ▲]

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See detailL’influence d’une formation au tutorat sur les performances en résolution de problèmes et sur la motivation autodéterminée d’élèves de fin d’enseignement primaire
Sandron, Laurence; Fagnant, Annick ULiege

in Revue Française de Pédagogie (in press)

L’objet de cette recherche exploratoire est d’évaluer l’efficacité d’un programme de formation au tutorat mis en place en résolution de problèmes en fin d’enseignement primaire (grade 6, élèves de 11-12 ... [more ▼]

L’objet de cette recherche exploratoire est d’évaluer l’efficacité d’un programme de formation au tutorat mis en place en résolution de problèmes en fin d’enseignement primaire (grade 6, élèves de 11-12 ans). La formation au tutorat s’appuyant sur la théorie de l’autodétermination (Ryan & Deci, 2000 a, b) consiste en un enseignement explicite de stratégies cognitives et métacognitives (Mevarech & Kramarski, 2014 ; Montague & Asha Jitendra, 2006). Le dispositif mis en place permet de comparer trois modalités : élèves formés au tutorat selon l’approche susmentionnée, élèves pratiquant le tutorat sans formation spécifique et élèves travaillant sur les mêmes problèmes que dans les deux autres classes mais sans pratiquer le tutorat. Les résultats montrent que la formation des tuteurs améliore les interactions au sein des dyades, les performances des élèves (tuteurs et tutorés) ainsi que certaines composantes de la motivation autodéterminée. [less ▲]

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See detailDo Geographical Indications Really Increase Trade? A Conceptual Framework and Empirics
Sorgho, Zakaria ULiege; Larue, Bruno

in Journal of Agricultural & Food Industrial Organization (in press)

Production location matters to many consumers and regulators and policymakers are pressed to statue on labels about country of origin, local foods and geographical indications (GIs). This paper ... [more ▼]

Production location matters to many consumers and regulators and policymakers are pressed to statue on labels about country of origin, local foods and geographical indications (GIs). This paper investigates the incidence of the EU policy on GIs on bilateral trade flows. We develop ttheoretical arguments and provide empirical evidence to analyze heterogeneity in consumer preferences regarding country of origin (domestic versus foreign) and the implicit quality signals from GI logos. The objective of the paper is to investigate whether producing GIs really boots bilateral trade, assuming heterogeneity in consumers’ preference. We first develop an analytical framework of a simple partial equilibrium two-country model through a Cobb-Douglas utility structure to assess the impact of GIs on trade. In addition, we empirically corroborate the analytical findings with a unique data on protected GIs by product and European country. Our main findings indicate that GI-products have ambiguous effect on international trade. Indeed, their trade-impact depends on the importance of product for consumers (i.e., the intensity and the reputation of GI-product considered as deterministic weight in consumers’ preference). As expected, a heterogeneity in consumers’ preference – due to home bias about local or foreign varieties – can increase or decrease trade, despite the presence of GI-products. [less ▲]

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See detailConsensus report: Peri-implant diseases and conditions
Berglundh, Tord; Armitage, Gary; Avila-Ortiz, Gustavo et al

in Journal of Periodontology (in press)

A classification for peri-implant diseases and conditions was presented. Focused questions on the characteristics of peri-implant health, peri-implant mucositis, periimplantitis, and soft- and hard-tissue ... [more ▼]

A classification for peri-implant diseases and conditions was presented. Focused questions on the characteristics of peri-implant health, peri-implant mucositis, periimplantitis, and soft- and hard-tissue deficiencies were addressed. Peri-implant health is characterized by the absence of erythema, bleeding on probing, swelling, and suppuration. It is not possible to define a range of probing depths compatible with health; of more importance are the clinical signs of inflammation. Peri-implant health can exist around implants with reduced bone support.The main clinical characteristic of peri-implant mucositis is bleeding on gentle probing. Erythema, swelling, and/or suppuration may also be present. An increase in probing depth is often observed in the presence of peri-implant mucositis due to swelling or decrease in probing resistance. There is strong evidence from animal and human experimental studies that plaque is the etiological factor for peri-implant mucositis. Peri-implantitis is a plaque-associated pathological condition occurring in tissues around dental implants, characterized by inflammation in the peri-implant mucosa and subsequent progressive loss of supporting bone. Peri-implantitis sites exhibit clinical signs of inflammation, bleeding on probing, and/or suppuration, increased probing depths and/or recession of the mucosal margin in addition to radiographic bone loss. The evidence is equivocal regarding the effect of keratinized mucosa on the longterm health of the peri-implant tissue. It appears, however, that keratinized mucosa may have advantages regarding patient comfort and ease of plaque removal. Case definitions in day-to-day clinical practice and in epidemiological or diseasesurveillance studies for peri-implant health, peri-implant mucositis, and periimplantitis were introduced. The proposed case definitions should be viewed within the context that there is no generic implant and that there are numerous implant designs with different surface characteristics, surgical and loading protocols. It is recommended that the clinician obtain baseline radiographic and probing measurements following the completion of the implant-supported prosthesis. [less ▲]

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See detailThe European Public Sectors in the Age of Managerialism
Esposito, Giovanni ULiege; Ferlie, Ewan; Gaeta, Giuseppe Lucio

in Politics (in press)

During the past 50 years, European public sectors have undergone a profound process of organizational change, where managerial tools and principles from the private sector have permeated through ... [more ▼]

During the past 50 years, European public sectors have undergone a profound process of organizational change, where managerial tools and principles from the private sector have permeated through governments and administrations of many countries. A substantial amount of academic literature has now been devoted to public management reforms. Many scholars have associated them with the diffusion of a managerialist ideology. However, the relationship between public management reforms, political ideology, and public expressions of support for these reforms by political parties has been a relatively under-explored topic within the literature and is the gap we address in this article. Using a longitudinal framework of study, our analysis shows how issues surrounding managerialist reforms have evolved across the electoral manifestos of European parties during the past 50 years. Our findings reveal that these reforms have enjoyed a growing political profile over time in many countries within Western and Eastern Europe. Furthermore, we also examine and discuss the differences and similarities of these reforms across countries. [less ▲]

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See detailDifferential control of appetitive and consummatory sexual behavior by neuroestrogens in male quail
Cornil, Charlotte ULiege; Ball, Gregory; Balthazart, Jacques ULiege

in Hormones and Behavior (in press)

Estrogens exert pleiotropic effects on multiple physiological and behavioral traits including sexual behavior. These effects are classically mediated via binding to nuclear receptors and subsequent ... [more ▼]

Estrogens exert pleiotropic effects on multiple physiological and behavioral traits including sexual behavior. These effects are classically mediated via binding to nuclear receptors and subsequent regulation of target gene transcription. Estrogens also affect neuronal activity and cell-signaling pathways via faster, membrane-initiated events. Although the distinction between appetitive and consummatory aspects of sexual behavior has been criticized, this distinction remains valuable in that it facilitates the causal analysis of certain behavioral systems. Effects of neuroestrogens produced by neuronal aromatization of testosterone on copulatory performance (consummatory aspect) and on sexual motivation (appetitive aspect) are described in male quail. The central administration of estradiol rapidly increases expression of sexual motivation, as assessed by two measures of sexual motivation produced in response to the visual presentation of a female but not sexual performance in male Japanese quail. This effect is mimicked by membrane-impermeable analogs of estradiol, indicating that it is initiated at the cell membrane. Conversely, blocking the action of estrogens or their synthesis by a single in- tracerebroventricular injection of estrogen receptor antagonists or aromatase inhibitors, respectively, decreases sexual motivation within minutes without affecting performance. The same steroid has thus evolved com- plementary mechanisms to regulate different behavioral components (motivation vs. performance) in distinct temporal domains (long- vs. short-term) so that diverse reproductive activities can be properly coordinated. Changes in preoptic aromatase activity and estradiol as well as glutamate concentrations are observed during or immediately after copulation. The interaction between these neuroendocrine/neurochemical changes and their functional significance is discussed. [less ▲]

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See detailGlobal Island Monitoring Scheme (GIMS): a proposal for the long‐term coordinated survey and monitoring of native island forest biota
Borges, PAV; Cardoso, P; Kreft, H et al

in Biodiversity & Conservation (in press)

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See detailPer una edizione integrale e analitica dell'incipit della Storia d'Italia di Francesco Guicciardini
Moreno, Paola ULiege

in Laboratoire Italien : Politique et Société (in press)

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See detailThe regulation of birdsong by testosterone: Multiple time-scales and multiple sites of action
Alward, Beau; Cornil, Charlotte ULiege; Balthazart, Jacques ULiege et al

in Hormones and Behavior (in press)

Sex steroid hormones act during early development to shape the circuitry upon which these same hormones act in adulthood to control behavioral responses to various stimuli. The “organizational” vs ... [more ▼]

Sex steroid hormones act during early development to shape the circuitry upon which these same hormones act in adulthood to control behavioral responses to various stimuli. The “organizational” vs. “activational” dis- tinction was proposed to explain this temporal difference in hormone action. In both of these cases steroids were thought to act genomically over a time-scale of days to weeks. However, sex steroids can affect behavior over short (e.g., seconds or minutes) time-scales. Here, we discuss how testosterone controls birdsong via actions at different sites and over different time-scales, with an emphasis on this process in canaries (Serinus canaria). Our work shows that testosterone in the medial preoptic nucleus regulates the motivation to sing, but not aspects of song performance. Instead, different aspects of song performance are regulated by long-term actions of testos- terone in steroid-sensitive cortical-like brain regions and the syrinx, the avian vocal production organ. On the other hand, acute aromatase inhibition rapidly reduces the availability of estrogens and this reduction is cor- related with reductions in the motivation to sing and song performance. Thus, testosterone and its estrogenic metabolites regulate distinct features of birdsong depending on the site and temporal window of action. The number of brain areas expressing androgen receptors is higher in species producing learned vocalization as compared to species that produce unlearned calls. An appealing scenario is that rapid effects of steroids in specific brain regions is a derived trait secondary to the widespread genomic effects of steroids in systems where steroids coordinate morphological, physiological, and behavioral traits. [less ▲]

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See detailTranscranial direct current stimulation unveils covert consciousness
Thibaut, Aurore ULiege; Chatelle, Camille ULiege; VANHAUDENHUYSE, Audrey ULiege et al

in Brain Stimulation (in press)

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See detailLevallois et Gravettien
Otte, Marcel ULiege; Noiret, Pierre ULiege

in Praehistoria (in press)

Par opposition à ceux de l’Aurignacien, les ensembles lithiques gravettiens procèdent selon une méthode rappelant le Levallois quant à la préparation des supports. Mais les variations observables au sein ... [more ▼]

Par opposition à ceux de l’Aurignacien, les ensembles lithiques gravettiens procèdent selon une méthode rappelant le Levallois quant à la préparation des supports. Mais les variations observables au sein du Gravettien touchent autant les processus de symbolisation dans l’art et les sépultures. Elles affectent différents substrats eurasiatiques, plutôt septentrionaux, comme mis en réserve dès les Néandertaliens. [less ▲]

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See detailThe Drivers of Structural Change
Van Neuss, Leif ULiege

in Journal of Economic Surveys (in press)

The main goal of this paper is to provide an integrated survey of the literature devoted to identifying the drivers of structural change, broadly defined as the process of reallocation of economic ... [more ▼]

The main goal of this paper is to provide an integrated survey of the literature devoted to identifying the drivers of structural change, broadly defined as the process of reallocation of economic activity across the three broad sectors agriculture, manufacturing and services. Using the GGDC 10-Sector Database, this paper first presents the empirical facts associated with structural change in different regions of the world – i.e. Europe and the USA, Asia, Latin America, and Africa – then reviews four determinants of structural change: (i) changes in income, (ii) changes in relative (sectoral) prices, (iii) changes in input-output linkages and (iv) changes in comparative advantage(s) via globalization and trade. [less ▲]

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See detailEvent segmentation and the temporal compression of experience in episodic memory
Jeunehomme, Olivier ULiege; D'Argembeau, Arnaud ULiege

in Psychological Research (in press)

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See detailInterferometric investigation of the gas-state monolayer of monorhamnolipid adsorbing at an oil/water interface.
Brocca, Paola; Rondelli, Valeria; Corti, M et al

in Journal of Molecular Liquids (in press)

We present a study on biosurfactant uptake at the interface of a millimeter-sized drop of squalene in water, by a recently developed differential interferometric technique. The technique allows detecting ... [more ▼]

We present a study on biosurfactant uptake at the interface of a millimeter-sized drop of squalene in water, by a recently developed differential interferometric technique. The technique allows detecting capillary waves, with amplitudes of the order of 10-9 m, excited on the surface of the drop by an electric field in the order of 5V/cm. By studying the resonant surface modes of the drop it is possible to assess the interfacial properties as a function of the surfactant concentration in the water bulk. The technique allows to follow the adsorption process at extremely low surfactant concentration, not accessible by other methods, investigating the gas state in the π-A diagrams of 2D amphiphilic monolayers. [less ▲]

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See detailTracing Lost Editions of Parisian Printers in the Sixteenth Century: The Case of Jean Bonfons and his Widow
Adam, Renaud ULiege

in The Library: The Transactions of the Bibliographical Society (in press)

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See detailFormes narratives et jugement : réflexions sur l'identité dans l'espace médiatique
Servais, Christine ULiege

in Sociologie (in press)

L’auteure s’attache dans cet article à définir plusieurs formes d’apparitions publiques de l’identité en les mettant en relation avec le jugement. L’hypothèse qui est défendue est que les événements ... [more ▼]

L’auteure s’attache dans cet article à définir plusieurs formes d’apparitions publiques de l’identité en les mettant en relation avec le jugement. L’hypothèse qui est défendue est que les événements racontés dans un « récit de soi » (qu’il soit ou non à la première personne) le sont dans le cadre d’une relation d’interpellations réciproques. Cette relation façonne l’identité et lui donne forme, en même temps qu’elle appelle le public à en répondre de différentes manières, et appelle par conséquent différentes formes de jugements publics. Sont ainsi distingués le drame, la narration, la récitation et le récit. Ce lien entre identité et jugement est illustré par des exemples puisés dans la presse écrite puis par l’analyse d’une une vidéo youtube [less ▲]

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See detailHumor Associated with Positive Outcomes in Individual Psychotherapy
Panichelli, Christophe; Albert, Adelin; Donneau, Anne-Françoise ULiege et al

in American journal of psychotherapy (in press), APT-2018-0021

Considerable anecdotal evidence points to the usefulness of humor in the therapeutic process, but empirical evidence is still lacking. This study searched for an association between humor and therapy ... [more ▼]

Considerable anecdotal evidence points to the usefulness of humor in the therapeutic process, but empirical evidence is still lacking. This study searched for an association between humor and therapy outcomes in a real-life population of 110 adult psychotherapy clients who attended at least 10 therapy sessions. Clients and their therapist evaluated the frequency and intensity of humorous events, as well as therapy effectiveness, therapeutic alliance, perceived hope and pleasure to participate in therapy sessions. We found a strong positive correlation between humor and therapy effectiveness, in both client (rs = .40; p < .0001) and therapist perspectives (rs = .37; p < .0001). The link between humor and effectiveness remained significant in more severe subgroups of clients, even though these clients reported less humor in their therapies. Further research is needed to determine if humor actually enhances therapy outcomes, or if positive outcomes trigger the occurrence of humor. [less ▲]

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See detailObjet et pratiques sémiotiques : Quelques enjeux médiatiques du support photographique
Honba Honba, Cédric ULiege

in Signata. Annales des Sémiotiques = Annals of Semiotics (in press)

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See detailRéduire l’altérité au travers des processus de traduction et de représentation
Leclercq, Bruno ULiege; Smette, Bernard ULiege

in Doctorales. Revue LLA-SHS de Montpellier (in press)

WVO Quine questions the « myth » of an ideal realm of shared meanings which every national language would express in its own way. Against the hope of transparent translations, he insists on the necessity ... [more ▼]

WVO Quine questions the « myth » of an ideal realm of shared meanings which every national language would express in its own way. Against the hope of transparent translations, he insists on the necessity for building equivalences from one language to another through a strategy of reducing the differences in rationality among nations as much as possible. According to Quine, otherness is not insuperable impediment to meeting/encounter and mutual understanding ; by throwing our conceptual schemes on the other communities’ uses/practices – which of course involves some symbolic violence – gaps can always been narrowed. Similarly E. Laclau questions the traditional conception of political representation, which is seen as the transparent process of transmitting someone’s will or interests on another level. For this ideal conception of representation, Laclau substitutes a pragmatic conception which takes in account the irreducible gap between the actors as well as the constitutive opacity of the process of representation : the subject’s will is constituted within the process of representation and through the representative’s productive role. In order to be transposed at the decision-making level, the subject’s interests must be translated by the representative as well as be negotiated with the other represented interests. This implies that the initial will undergoes some identity transformations. [less ▲]

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See detailMood Disorders Patients Treated in a Day Hospital: Focus on Changes in Alexithymia and Openness to Emotions
Triffaux, Jean-Marc ULiege; Nasello, Julian ULiege; Servais, Catherine et al

in Clinical Psychiatry (in press)

Alexithymia and Openness to Emotions (OE) are strongly linked to mood disorders. Alexithymia represents the difficulty of giving words to emotions, whilst OE refers to cognitive representation ... [more ▼]

Alexithymia and Openness to Emotions (OE) are strongly linked to mood disorders. Alexithymia represents the difficulty of giving words to emotions, whilst OE refers to cognitive representation, communication and regulation aspects of emotions. We investigated variables impacting both alexithymia and OE for mood disorder patients (N = 73), before and after a treatment period in a day psychiatric hospital. Significant score changes and, notably, significant impacts of perceived social support were expected. [less ▲]

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See detailAlgebraic thinking, pattern activities and knowledge for teaching at the transition between primary and secondary school.
Demonty, Isabelle ULiege; Vlassis, Joëlle; Fagnant, Annick ULiege

in Educational Studies in Mathematics (in press)

Research focusing on algebra from primary to early secondary school level has made several major advances over the past decades. Students’ difficulties have been identified and supportive teaching and ... [more ▼]

Research focusing on algebra from primary to early secondary school level has made several major advances over the past decades. Students’ difficulties have been identified and supportive teaching and learning environments have been set up (Cai & Knuth, 2011; Kieran, 2007; Radford, 2008, 2014). The effectiveness of these environments relies on the teachers’ ability to pay careful attention to students’ thinking, which then guides their instructional decisions. This inevitably raises the crucial question of the teachers’ knowledge for managing these types of situations in the classroom. In this context, this paper focuses on the mathematical knowledge for teaching figural pattern activities of 100 teachers at the primary and early secondary school levels. The results show that many primary teachers lack the essential knowledge for teaching these types of activities: they do not have a clear idea of their goal, they do not consider non-standard algebraic generalisations to be correct and they generally seem unable to help students to improve their arithmetical generalisation. Secondary school teachers also seem unable to give adequate feedback to improve students’ arithmetical generalisation. Although they seem to recognise that these activities are intended to improve algebraic thinking, they do not have a clear perception of the role that primary school learning can play in the development of this algebraic thinking [less ▲]

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See detailENHANCED AND PREFERENTIAL INTERNALIZATION OF LIPID NANOCAPSULES INTO HUMAN GLIOBLASTOMA CELLS: EFFECT OF SURFACE-FUNCTIONALIZING NFL PEPTIDE
Reatul, Karim; Lepeltier, Elise; Esnault, Lucille et al

in Nanoscale (in press)

Increasing intracellular drug concentration using nanocarriers can be a potential strategy to improve efficacy against glioblastoma (GBM). Here, the fluorescent-labelled NFL-TBS.40-63 peptide (fluoNFL ... [more ▼]

Increasing intracellular drug concentration using nanocarriers can be a potential strategy to improve efficacy against glioblastoma (GBM). Here, the fluorescent-labelled NFL-TBS.40-63 peptide (fluoNFL) concentration on lipid nanocapsule (LNC) was studied to enhance nanovector internalization into human GBM cells. The LNC surface-functionalization with various fluoNFL concentrations was performed by adsorption. LNC size and surface charge altered gradually with increasing peptide concentration, but their complement protein consumption remained low. Desorption of fluoNFL from LNC surface was found to be slow. Furthermore, it was observed that the rate and extent of LNC internalization in the U87MG human glioblastoma cells were dependent on the surface-functionalizing fluoNFL concentration. In addition, we showed that the uptake of fluoNFL-functionalized LNCs was preferential towards U87MG cells compared to healthy human astrocytes. The fluoNFL-functionalized LNC internalization into the U87MG cells was energy-dependent and occurred possibly by macropinocytosis, clathrin-mediated and caveolin-mediated endocytosis. A new ferrocifen-type molecule (FcTriOH), as potent anticancer candidate, was then encapsulated in the LNCs and the functionalization improved its in vitro efficacy compared to other tested formulations against U87MG cells. In the preliminary study, on subcutaneous human GBM tumor model in nude mice, a significant reduction of relative tumor volume was observed at one week after the second intravenous injection with FcTriOH-loaded LNCs. These results showed that enhancing NFL peptide concentration on LNC surface is a promising approach for increased and preferential nanocarrier internalization into human GBM cells, and the FcTriOH-loaded LNCs are promising therapy approach for GBM. [less ▲]

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See detailFigement, langage et didactique du français
Steffens, Marie ULiege

in Langues et Linguistique (in press), (37),

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See detailDecline of empathy among medical students : dehumanization or useful coping process ?
Triffaux, Jean-Marc ULiege; Tisseron, Serge; Nasello, Julian ULiege

in Encéphale (L') (in press)

Empathy is central in patient-physician interactions and understanding its development is decisive for education. However, scientific literatures report a striking decline of empathy among medical ... [more ▼]

Empathy is central in patient-physician interactions and understanding its development is decisive for education. However, scientific literatures report a striking decline of empathy among medical students during their study course. Firstly, we aimed to replicate this result on a Belgian population. Secondly, as well reported by literature, we expected higher empathy scores for women. Lastly, as central, we expected higher empathy levels for medical students than for “control” students (commercial students were used as a control group: social interactions without a curing aspect) at the beginning of their study course, suggesting that empathy drives students to select specific education fields. [less ▲]

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See detailIntravenous lipid emulsions in paediatric patients
Lapillonne, A; Didler Mis, N; Goulet et al

in Clinical Nutrition (in press)

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See detailPhotologie, linéarité et modernité politique. Du geste philosophique derridien
Petteni, Oriane ULiege

in Ethique, politique, religions (in press), 1/n°12

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See detailHow flexible is the use of egocentric versus allocentric frame of reference in the Williams syndrome population?
Heiz, Julie; Majerus, Steve ULiege; Barisnikov, Koviljka

in Archives of Clinical Neuropsychology (in press)

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See detailDetection of plant protein adulterated in fluid milk using twodimensional gel electrophoresis combined with mass spectrometry
Yang, Jinhui; Zheng, Nan; Yang, Yongxin et al

in Journal of Food Science and Technology (in press)

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See detailSeagrass organic matter transfer in Posidonia oceanica macrophytodetritus accumulations
Remy, François ULiege; Mascart, Thibaud; De Troch, Marleen et al

in Estuarine Coastal & Shelf Science (in press)

Seagrass ecosystems are net autotrophic systems which contribute to organic carbon burial in marine sediment. Dead seagrass leaves are often exported outside the seagrass beds and may form accumulations ... [more ▼]

Seagrass ecosystems are net autotrophic systems which contribute to organic carbon burial in marine sediment. Dead seagrass leaves are often exported outside the seagrass beds and may form accumulations (exported macrophytodetritus accumulations, hereafter EMAs) from littoral zones to deepest canyons. Understanding how seagrass organic matter is channeled in its associated trophic web is necessary to assess the role of the seagrass ecosystem as blue carbon service providers. We used gut content and stable isotope analyses to delineate the Posidonia oceanica EMA food web structure and to determine the importance of detrital material in the diets of macrofauna. Evidence from gut contents and stable isotopes showed that this food web is fuelled mainly by two food sources found in the detritus accumulations: 1) P. oceanica detritus itself and 2) epiphytes and drift macroalgae. Dead leaves of P. oceanica enter the diet of dominant species, representing more than 60% of animal abundance. The food web is structured in five trophic levels with a numerical dominance of detritivore/herbivore species at the first consumer level. Animals act as a vector for seagrass organic matter transfer to upper trophic levels and this “dead seagrass signal” is followed through the entire food web. Seagrass primary production and seagrass organic matter processing by animals are spatially decoupled and this should be taken into account in assessments of seagrass ecosystems as key actors in C cycles in coastal areas. [less ▲]

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See detailExposure of workers to pesticide residues during re-entry activities: A Review
Toumi, Khaoula ULiege; Joly, Laure; Vleminckx, Christiane et al

in Human and Ecological Risk Assessment (in press)

Workers may be exposed to pesticide residues when they enter an area that has been previously treated in order to realize different tasks (e.g. for pruning, cutting, picking, harvesting, pest scouting) or ... [more ▼]

Workers may be exposed to pesticide residues when they enter an area that has been previously treated in order to realize different tasks (e.g. for pruning, cutting, picking, harvesting, pest scouting) or to handle a contaminated crop commodity (e.g. sorting, bundling, packing). A review of the scientific literature on workers exposed to pesticide residues during re-entry tasks provides a comprehensive view of possible exposure routes and a better understanding of the risk assessment context, threshold values and calculation methodology. Methods assessing the risk to workers health are also reported and discussed. The impact of re-entry activities on health and factors affecting workers exposure are examined. Finally, solutions and mitigation measures aiming to reduce their exposure to pesticide residues are recommended. [less ▲]

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See detailSupplementation with 80,000 IU vitamin D3/month between November and April corrects vitamin D insufficiency without overdosing: Effect on serum 25-hydroxyvitamin D serum concentrations.
Tournier, Herve; Tran, Nicole; Dray, Nathalie et al

in Presse medicale (Paris, France : 1983) (in press)

INTRODUCTION: Vitamin D insufficiency, defined by a 25-hydroxyvitamin D (25OHD) serum concentration<20ng/mL, is highly frequent in the French general population, especially between November and April. The ... [more ▼]

INTRODUCTION: Vitamin D insufficiency, defined by a 25-hydroxyvitamin D (25OHD) serum concentration<20ng/mL, is highly frequent in the French general population, especially between November and April. The aim of this study was to evaluate whether 80,000 IU vitamin D3 every month during this period of the year was able to maintain a 25OHD level between 20 and 60ng/mL in apparently healthy subjects whatever their basal vitamin D status. METHODS: Ninety-eight subjects volunteered to receive an 80,000 IU vitamin D3 dose every month between November 2014 and April 2015. Serum 25OHD, calcemia and calciuria were measured just before the first dose (Month 0), just before the 4th dose (M4), and one month after the 6th dose (M7). RESULTS: At M0, 25OHD was 17.5+/-9.5ng/mL. Sixty subjects (61.2%) had a 25OHD<20ng/mL and 25 (25.5%) had a 25OHD<10ng/mL. 25OHD increased significantly at M4 (35.3+/-8.0ng/mL) and M7 (40.1+/-8.5) without change in calcemia and calciuria. At M4, 2 subjects had a 25OHD slightly below 20ng/mL (17.6 and 19.7ng/mL), and none had a concentration>60ng/mL. At M7, all had a serum 25OHD>20ng/mL and 2 subjects had a value slightly above 60ng/mL (62.1 and 63.2ng/mL). CONCLUSION: A monthly supplementation with 80,000 IU vitamin D3 between November and April corrected vitamin D insufficiency in subjects in whom it was initially very frequent, without overdosing. This protocol is simple, safe and costless, and can be easily implemented when physicians detect risk factors for hypovitaminosis D in patients for whom a 25OHD measurement is not indicated. [less ▲]

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See detailLa terminologie grecque et latine du plurilinguisme
Rochette, Bruno ULiege

in Lingue Antiche e Moderne (in press)

The aim of this article is to study the words and expressions in Greek and Latin relating to multilingualism, especially the compounds in –φωνος and in –γλωσσος in Greek and those in –lingua in Latin. I ... [more ▼]

The aim of this article is to study the words and expressions in Greek and Latin relating to multilingualism, especially the compounds in –φωνος and in –γλωσσος in Greek and those in –lingua in Latin. I start by examining some texts related to the awareness of the linguistic diversity and multilingualism in Greece, in Rome and in the Jewish-Christian thought, from Homer to Augustine. Next, after having studied the terminology in Greek and Latin, I consider some case studies of inter-linguistic communication and multilingualism in Greek and Latin authors. In the conclusion, I compare the ancient terminology of the multilingualism with some aspects of the modern terminology in French. [less ▲]

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See detailFirst geochimichal sourcing of 'Balkan flint' and 'Prut flint' from Palaeolithic Romania: potentials, limitations and future directions
Moreau, Luc; Ciornei, A.; Gjesfjelds, E. et al

in Archaeometry (in press)

Attributions of flint artefacts to specific geographical sources ideally require some form of independent validation through suitable petrographical and/or geochemical analyses, given the implications of ... [more ▼]

Attributions of flint artefacts to specific geographical sources ideally require some form of independent validation through suitable petrographical and/or geochemical analyses, given the implications of raw material transfer on interpretations of prehistoric mobility and land-use strategies. We investigated the potential to ‘fingerprint’ flint from two archaeological sites in Eastern Romania – Mitoc-Malu Galben and Bistricioara-Lutărie III, using Laser Ablation – Inductively Coupled Plasma – Mass Spectrometry (LA-ICP-MS) in combination with multivariate statistical analysis. Our results suggest that geochemical analyses do not yet have the level of resolution required to assign single artefacts to specific geographic locations in the context of Romania and Bulgaria. The mismatches of signatures between training and test data however raise new questions and open unforeseen perspectives. [less ▲]

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See detailThe use of time series forecasting in zone order picking systems to predict order pickers’ workload
van Gils, Teun; Ramaekers, Katrien; Caris et al

in International Journal of Production Research (in press)

In order to differentiate from competitors in terms of customer service, warehouses accept late orders while providing delivery in a quick and timely way. This trend leads to a reduced time to pick an ... [more ▼]

In order to differentiate from competitors in terms of customer service, warehouses accept late orders while providing delivery in a quick and timely way. This trend leads to a reduced time to pick an order. This paper introduces workload forecasting in a warehouse context, in particular a zone picking warehouse. Improved workforce planning can contribute to an effective and efficient order picking process. Most order picking publications treat demand as known in advance. As warehouses accept late orders, the assumption of a constant given demand is questioned in this paper. The objective of this study is to present time series forecasting models that perform well in a zone picking warehouse. A real-life case study demonstrates the value of applying time series forecasting models to forecast the daily number of order lines. The forecast of order lines, along with order pickers’ productivity, can be used by warehouse supervisors to determine the daily required number of order pickers, as well as the allocation of order pickers across warehouse zones. Time series are applied on an aggregated level, as well as on a disaggregated zone level. Both bottom-up and top-down approaches are evaluated in order to find the best-performing forecasting method. [less ▲]

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See detailLes Héroïnes Noires du Cinéma Black-British : Regards Masculins sur des Destins de Femmes (Burning an Illusion, 1981; Elphida, 1987; Babymother, 1998)
Herbert, Emilie ULiege

in Genre en séries : cinéma, télévision, médias (in press)

Inexistantes ou empreintes de stéréotypes négatifs, les représentations des femmes noires dans le cinéma britannique restent marginales. Les réalisateurs noirs eux-mêmes ont, depuis les débuts du cinéma ... [more ▼]

Inexistantes ou empreintes de stéréotypes négatifs, les représentations des femmes noires dans le cinéma britannique restent marginales. Les réalisateurs noirs eux-mêmes ont, depuis les débuts du cinéma Black-British , participé à cette invisibilisation en concentrant souvent leurs récits autour de héros masculins, reléguant les femmes noires à des rôles secondaires et unidimensionnels. Les réalisateurs Menelik Shabazz, Tunde Ikoli et Julian Henriques vont cependant dans les années 1980 et 1990 choisir de mettre en scène une femme noire comme personnage principal de leurs premiers longs-métrages. Ces films ont contribué à la pluralisation des représentations féminines noires à une époque où le travail des réalisatrices noires n'était que difficilement accessible en Grande-Bretagne, et leurs héroïnes exultent une britannicité redéfinie par les questions de genre, de "race" et de classe. [less ▲]

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See detailLe lettere bipartite e i discorsi politici di Francesco Guicciardini nell’anno 1525
Miesse, Hélène ULiege

in Giornale Storico della Letteratura Italiana (in press)

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See detailExploration of relationship between parental distress, family functioning and post-traumatic symptoms in children
Gallo, Alicia ULiege; Wertz, Céline ULiege; Kairis, Sophie et al

in European Journal of Trauma and Dissociation (in press)

We investigated the links between peritraumatic distress in children and in their parents following a potentially traumatic event, focusing specifically on the role that parents and family functioning can ... [more ▼]

We investigated the links between peritraumatic distress in children and in their parents following a potentially traumatic event, focusing specifically on the role that parents and family functioning can play in the development and maintenance of post-traumatic disorders in children. To this end, we examined a population of 41 children (aged 8 and above), and their parents, who had been admitted to the emergency room of a pediatric hospital due to an accident. The design included a two-step assessment: immediate reactions (in the hours following the event) and delayed reactions (5-8 weeks after the event). We used six questionnaires to assess reactions. The results indicated a statistically significant positive correlation between the intensity of the peri-traumatic distress of the parents and the level of post-traumatic symptoms observed later (5 to 8 weeks after the event) in the questionnaires administered to the children. Regarding educational practices, differences appear to be linked to maternal education practice and to the severity of child’s symptomatology. Finally, a link has been established between changes within the family dynamic after a potentially traumatic event and the severity of child’s post traumatic symptoms. This study showed the extent to which the parents’ initial reactions can be decisive in the outcome for a child who has experienced a potentially traumatic event. The study highlights the importance of assessing parental responses as well as paying attention to the children when they arrive in a pediatric emergency room. The results are relevant for prevention and treatment of PTSD in children, as the integration of this parental dimension early on in the process may lead to improved identification of which young patients are at risk of developing post-traumatic symptomatology. [less ▲]

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See detailL'utilisation du ratio sFlt-1/PlGF dans la prééclampsie: une analyse rétrospective monocentrique
Verbeurgt, Lievine ULiege; CHANTRAINE, Frédéric ULiege; DE MARCHIN, Jérôme et al

in Revue Médicale de Liège (in press)

La fms-like tyrosine kinase 1 soluble (sFlt-1) est un facteur anti-angiogénique libéré en quantité excessive dans la prééclampsie (PE) et impliqué dans la dysfonction endothéliale. Il est comparé au ... [more ▼]

La fms-like tyrosine kinase 1 soluble (sFlt-1) est un facteur anti-angiogénique libéré en quantité excessive dans la prééclampsie (PE) et impliqué dans la dysfonction endothéliale. Il est comparé au facteur de croissance placentaire pro-angiogénique (PlGF) qui diminue dans la PE. Le ratio sFlt-1/PlGF est présenté dans la littérature comme outil dans la prédiction de la prééclampsie. Un ratio < 38 confirme l’absence de prééclampsie à court-terme. Un ratio ≥ 85 dans la PE précoce (avant 34 semaines aménorrhée (SA)) et ≥ 110 dans le «late onset» (> 34 semaines d’aménorhhée) peut poser le diagnostic de prééclampsie. Dans cette étude rétrospective monocentrique, le ratio sFlt-1/PlGF a été dosé chez 183 patientes à risque dont 67 ont présenté une prééclampsie. Le ratio sFlt-1/PlGF médian pour toutes les patientes évaluées est 100,3. Le ratio médian pour les patientes ayant déclaré une prééclampsie (N=67) est 212,7 alors que celui des femmes sans prééclampsie (N=116) est de 35,4. En accord avec ces analyses, un ratio sFlt-1/PlGF ≥ 38 possède une sensibilité égale à 95,5% et une spécificité égale à 73,3%. Les valeurs prédictives positive (VPP) et négative (VPN) sont, respectivement, 67,4% et 96,6%. Ces résultats suggèrent que le ratio sFlt-1/PlGF peut être une aide dans le diagnostic de la prééclampsie [less ▲]

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See detailTrouble de personnalité borderline et temps vécu
Lo Monte, Fabian; Englebert, Jérôme ULiege

in Evolution Psychiatrique (in press)

Objectifs : Partant du constat de l’importante hétérogénéité sémiologique présentée par les sujets état-limite, cette contribution tente de faire émerger une charpente psychopathologique du trouble de ... [more ▼]

Objectifs : Partant du constat de l’importante hétérogénéité sémiologique présentée par les sujets état-limite, cette contribution tente de faire émerger une charpente psychopathologique du trouble de personnalité borderline afin de mieux comprendre le vécu des patients affectés par ce dernier. Méthode : Le temps vécu est l’angle d’attaque principal choisi dans cet article. La réflexion s’articule autour des notions d’instantanéité et d’immédiateté et en explore les différentes significations. Les autres coordonnées existentielles communément investiguées en psychopathologie phénoménologique, comme les rapports à l’espace, à l’identité, au vécu émotionnel ou au corps sont également étudiées. Résultats : La fragmentation temporelle du soi (Fuchs, 2007) que nous décrivons peut être considérée comme organisant le rapport aux principales fonctions psychiques chez les patients borderline, et révèle un être-au-monde tendant vers un dépassement de la situation spatio-temporelle. En outre, la façon de vivre le temps que Kimura (1992) nomme intra festum, qui est étroitement liée aux notions d’instantanéité et d’immédiateté telles que nous les développons, semble se combiner de façon fructueuse avec la fragmentation temporelle du soi et le dépassement de la situation. Discussion : La combinaison entre l’augmentation de la prévalence du trouble et la qualité des expériences rapportées par les patients permet de suggérer un lien entre l’être-au-monde borderline et l’évolution de notre société, faite d’avancées technologiques incessantes à-mêmes de permettre une modification des coordonnées spatio-temporelles. Conclusion : Les différentes conceptions exposées dans cet article semblent finalement se rejoindre autour des notions d’instantanéité et d’immédiateté. Ces deux termes, très proches mais convoquant des points de vue différents, semblent entretenir un lien étroit avec une certaine hypo-réflexivité. Celle-ci s’exprime à des degrés divers selon que l’on se situe dans la « normalité » ou la pathologie, et peut être comprise en lien à un contexte social caractérisé par une nécessité d’hyper-flexibilité quotidienne (qui nous ramène à nouveau à l’immédiateté et à l’instantanéité). Ainsi, plusieurs points de l’expérience borderline peuvent être rapprochés du mode de vie postmoderne, et cela révèle les dimensions potentiellement adaptatives de ce trouble de la personnalité. [less ▲]

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See detailDisulfide Connectivity Analysis of Peptides Bearing Two Intramolecular Disulfide Bonds Using MALDI In-Source Decay
Massonnet, Philippe ULiege; Haler, Jean ULiege; Uper, Gregory et al

in Journal of the American Society for Mass Spectrometry (in press)

Disulfide connectivity in peptides bearing at least two intramolecular disulfide bonds is highly important for the structure and the biological activity of the peptides. In that context, analytical ... [more ▼]

Disulfide connectivity in peptides bearing at least two intramolecular disulfide bonds is highly important for the structure and the biological activity of the peptides. In that context, analytical strategies allowing a characterization of the cysteine pairing are of prime interest for chemists, biochemists, and biologists. For that purpose, this study evaluates the potential of MALDI in-source decay (ISD) for characterizing cysteine pairs through the systematic analysis of identical peptides bearing two disulfide bonds, but not the same cysteine connectivity. Three different matrices have been tested in positive and/or in negative mode (1,5-DAN, 2-AB and 2-AA). As MALDI-ISD is known to partially reduce disulfide bonds, the data analysis of this study rests firstly on the deconvolution of the isotope pattern of the parent ions. Moreover, data analysis is also based on the formed fragment ions and their signal intensities. Results from MS/MS-experiments (MALDI-ISD-MS/MS) constitute the last reference for data interpretation. Owing to the combined use of different ISD-promoting matrices, cysteine connectivity identification could be performed on the considered peptides. [less ▲]

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See detailMoi, Téreus enceinte et battue
Ricciardetto, Antonio ULiege; Gourevitch, Danielle

in Revue du Praticien (in press), 68

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See detailLes Trois Trois Petits Cochons et le Grand Méchant Loup. La rencontre de deux archétypes
Jousten, Lison ULiege

in La revue des lettres modernes (in press)

Image de la menace par excellence, le Grand Méchant Loup est un adversaire dont on ne compte plus les apparitions, notamment dans les fictions destinées au jeune public. Dans Les Trois Petits Cochons, qui ... [more ▼]

Image de la menace par excellence, le Grand Méchant Loup est un adversaire dont on ne compte plus les apparitions, notamment dans les fictions destinées au jeune public. Dans Les Trois Petits Cochons, qui s’impose comme cas d’école parmi ces récits où surgit l’animal redouté, le loup devient l’ennemi du cochon, une créature traditionnellement associée à l’enfance. Ce tandem, qui repose sur un principe général d’opposition, brasse avec lui une série de représentations qui transparaissent en filigrane. Le détour opéré par l’histoire culturelle du cochon et quelques-uns de ses prolongements cinématographiques permet de dessiner progressivement les contours de la place occupée par le loup dans ce conte. [less ▲]

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See detailL’immeuble, le bourgmestre et le programme de revitalisation urbaine
Vrancken, Martin ULiege

in Administration Publique : Revue du Droit Public et des Sciences Administratives (in press)

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See detailP.Tebt. 526v: A Land Registry from Tebtunis
Nocchi Macedo, Gabriel ULiege; Gilbert, Nathan

in Bulletin of the American Society of Papyrologists (in press)

Edition of a Greek land registry from Tebtunis

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See detailLe commerce du livre à Bruxelles au XVIe siècle
Adam, Renaud ULiege

in Histoire et Civilisation du Livre : Revue Internationale (in press), 14

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See detailDifferential contributions of default and dorsal attention networks to remembering thoughts and external stimuli from real-life events
Stawarczyk, David ULiege; Jeunehomme, Olivier ULiege; D'Argembeau, Arnaud ULiege

in Cerebral Cortex (in press)

Episodic memories are typically composed of perceptual information derived from the external environment and representations of internal states (e.g., one’s thoughts during prior episodes). To date ... [more ▼]

Episodic memories are typically composed of perceptual information derived from the external environment and representations of internal states (e.g., one’s thoughts during prior episodes). To date, however, research has mostly focused on the remembrance of external stimuli, such that little is known about how internal mentation is represented within episodic memory. In the present fMRI study, we examined the neural correlates of these two components of episodic memories using a novel method of cuing memories from photographs taken during real-life events. We found that, compared to corresponding semantic memory tasks, memories for internal thoughts and external elements were associated with activity in brain areas supporting episodic recollection. Most importantly, however, the two kinds of memories also showed differential activation in large-scale brain networks: the remembrance of external elements was associated with greater activity in the dorsal attention network, whereas memories of internal thoughts mainly recruited default network areas. These findings shed new light on the representation of internal and external aspects of prior experience within episodic memory. The default network may contribute to the reinstatement of thoughts experienced during past events, whereas the dorsal attention network may support the allocation of attention to visuo-spatial features within episodic memory representations. [less ▲]

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See detailDoes the development of syntax comprehension show a premature asymptote among persons with Down syndrome? A cross-sectional analysis
Facon, Bruno; Magis, David ULiege

in American journal on intellectual and developmental disabilities (in press)

Uncertainty persists regarding the post-childhood trajectory of syntactic acquisition of persons with Down syndrome (DS). In some studies asymptote is reached in the early teens, whereas others find ... [more ▼]

Uncertainty persists regarding the post-childhood trajectory of syntactic acquisition of persons with Down syndrome (DS). In some studies asymptote is reached in the early teens, whereas others find syntax continuing to develop at least into early adulthood. This study addressed the issue using a cross-sectional approach. Receptive syntax and receptive vocabulary were tested in 62 children, adolescents and young adults with DS matched on CA and cognitive level with 62 participants with intellectual disability of undifferentiated etiology. On both tests there were significant effects of CA and diagnosis, but the CA × diagnosis interactions were nonsignificant. It is concluded that comprehension of vocabulary and syntax does not asymptote prematurely among persons with DS. [less ▲]

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See detailIntégrer le droit international au champ des relations internationales : les juristes belges à Versailles en 1919
Genin, Vincent ULiege

in Relations internationales (in press), (2),

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See detailIntroduction
Adam, Renaud ULiege; Sorgeloos, Claude

in Histoire et Civilisation du Livre : Revue Internationale (in press), 14

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See detailXXL Survey XXI. The environment and clustering of X-ray AGN in the XXL-South field
Melnyk, O.; Elyiv, A.; Smolcic, V. et al

in Astronomy and Astrophysics (in press)

This work is part of a series of studies focusing on the environment and the properties of the X-ray selected active galactic nuclei (AGN) population from the XXL survey. The present survey, given its ... [more ▼]

This work is part of a series of studies focusing on the environment and the properties of the X-ray selected active galactic nuclei (AGN) population from the XXL survey. The present survey, given its large area, continuity, extensive multiwavelength coverage, and large-scale structure information, is ideal for this kind of study. Here, we focus on the XXL-South (XXL-S) field. Our main aim is to study the environment of the various types of X-ray selected AGN and investigate its possible role in AGN triggering and evolution. We studied the large-scale (>1 Mpc) environment up to redshift z=1 using the nearest neighbour distance method to compare various pairs of AGN types. We also investigated the small-scale environment (<0.4 Mpc) by calculating the local overdensities of optical galaxies. In addition, we built a catalogue of AGN concentrations with two or more members using the hierarchical clustering method and we correlated them with the X-ray galaxy clusters detected in the XXL survey. It is found that radio detected X-ray sources are more obscured than non-radio ones, though not all radio sources are obscured AGN. We did not find any significant differences in the large-scale clustering between luminous and faint X-ray AGN, or between obscured and unobscured ones, or between radio and non-radio sources. At local scales (<0.4 Mpc), AGN typically reside in overdense regions, compared to non-AGN; however, no differences were found between the various types of AGN. A majority of AGN concentrations with two or more members are found in the neighbourhood of X-ray galaxy clusters within <25-45 Mpc. Our results suggest that X-ray AGN are typically located in supercluster filaments, but they are also found in over- and underdense regions. [less ▲]

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See detailAuroral storm and polar arcs at Saturn - Final Cassini/UVIS auroral observations
Palmaerts, Benjamin ULiege; Radioti, Aikaterini ULiege; Grodent, Denis ULiege et al

in Geophysical Research Letters (in press)

On 15 September 2017 the Cassini spacecraft plunged into Saturn's atmosphere after 13 years of successful exploration of the Saturnian system. The day before, the Ultraviolet Imaging Spectrograph on board ... [more ▼]

On 15 September 2017 the Cassini spacecraft plunged into Saturn's atmosphere after 13 years of successful exploration of the Saturnian system. The day before, the Ultraviolet Imaging Spectrograph on board Cassini observed Saturn's northern aurora for about 14 h. During these observations, several auroral structures appeared, providing clues about processes simultaneously occurring in Saturn's magnetosphere. The observed dawn auroral enhancement together with the magnetic eld and plasma wave data suggest that an intense flux closure process took place in the magnetotail. This enhanced magnetotail reconnection is likely caused by a magnetospheric compression induced by an interplanetary shock. Additionally, a polar arc is observed on the duskside, tracked for the rst time from its growth until its quasi-disappearance, and used as an indicator of reconnection location on the dayside magnetopause. Observation of an atypical auroral arc at very high latitudes supports the interplanetary shock scenario. [less ▲]

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See detailUne enquête de police dans les milieux du livre à Bruxelles en 1689
Adam, Renaud ULiege; Meunier, Laurence

in Histoire et Civilisation du Livre : Revue Internationale (in press), 14

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See detailALPHAFLEX : Un nouveau test exécutif - Données normatives chez des sujets âgés de 50 ans et plus
Grotz, Catherine ULiege; Seron, Xavier; Adam, Stéphane ULiege

in Revue de Neuropsychologie (in press)

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See detailUnderstanding the Economic Determinants of the Severity of Operational Losses: A regularized Generalized Pareto Regression Approach
Hambuckers, julien ULiege; Groll, Andreas; Kneib, Thomas

in Journal of Applied Econometrics (in press)

We investigate a novel database of 10,217 extreme operational losses from the Italian bank UniCredit, covering a period of 10 years and 7 different event types. Our goal is to shed light on the dependence ... [more ▼]

We investigate a novel database of 10,217 extreme operational losses from the Italian bank UniCredit, covering a period of 10 years and 7 different event types. Our goal is to shed light on the dependence between the severity distribution of these losses and a set of macroeconomic, financial and firm-specific factors. To do so, we use Generalized Pareto regression techniques, where both the scale and shape parameters are assumed to be functions of these explanatory variables. In this complex distributional regression framework, we perform the selection of the relevant covariates with a state-of-the-art penalized-likelihood estimation procedure relying on $L_{1}$-norm penalty terms of the coefficients. A simulation study indicates that this approach efficiently selects covariates of interest and tackles spurious regression issues encountered when dealing with integrated time series. The results of our empirical analysis have important implications in terms of risk management and regulatory policy. In particular, we found that high Italian unemployment rate and low GDP growth rate in the European Union are associated with smaller probabilities of extreme severities, whereas high values of the VIX and high growth rates of housing prices are associated with more extreme losses. Looking at firm-specific factors, low leverage ratio and high deposit growth rate are associated with a higher likelihood of extreme losses. Lastly, we illustrate the impact of different economic scenarios on the requested capital for operational risk. We find important discrepancies across event types and scenarios. [less ▲]

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See detailTranslation, Adaptation, and Preliminary Validation of Dacakis and Davies' "Transsexual Voice Questionnaire (Male to Female)" in French.
Morsomme, Dominique ULiege; Revis, Joana; Thomas, Elisabeth

in Journal of Voice (in press)

Transgender MtF people (trans women) consult otorhinolaryngologists and vocologists with the aim of feminizing their voice and being consistently perceived as women. Treatment of these trans women always ... [more ▼]

Transgender MtF people (trans women) consult otorhinolaryngologists and vocologists with the aim of feminizing their voice and being consistently perceived as women. Treatment of these trans women always begins with a vocal assessment that is relatively unspecific as it was originally constructed for individuals with dysphonia. OBJECTIVES: This study examines the subjective portion of the assessment and specifically the self-assessment questionnaire. There is no French-language questionnaire designed to identify the issues facing people who want voice feminization and quantify the impact of their voice disorder on their daily lives. We present a translation and adaption into French of the questionnaire developed by Dacakis et al [6]. METHODS: This work follows the World Health Organization recommendations [12] regarding translation. Thirty-six Belgian and French trans women took part in this study. RESULTS: The results show excellent repeatability and reliability, while the construct validity measures show that the items correlate with six areas of concern for trans women identified by Davies and Johnson [7] in a previous study. The domains are the following: effect of voice on ease of social interaction, effect of voice on emotions, relationship between voice and gender identity, effort and concentration required to produce voice, physical aspects of voice production, and pitch. Concurrent validity could not be measured owing to lack of sufficiently detailed stories. CONCLUSION: The psychometric properties of the French version of the questionnaire are acceptable. The questionnaire can be used as is in daily clinical practice. [less ▲]

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See detailLes troubles du sommeil chez l'enfant autiste, quel rôle pour le pédopsychiatre?
Abate Ekollo, Joëlle; Malchair, Alain ULiege

in Acta Psychiatrica Belgica (in press)

Les troubles du sommeil sont fréquents chez l’enfant et leurs origines sont diverses. Ces troubles ont leur ancrage dans le développement neurophysiologique et psychoaffectif de l’enfant. Les enfants ... [more ▼]

Les troubles du sommeil sont fréquents chez l’enfant et leurs origines sont diverses. Ces troubles ont leur ancrage dans le développement neurophysiologique et psychoaffectif de l’enfant. Les enfants souffrant de troubles du spectre autistique présentent un déficit de sommeil, qui peut durer jusqu’à l’adolescence. Les troubles du spectre autistique comportent des comorbidités multiples, dont des altérations du sommeil. Ils sont importants à caractériser dans cette population, car ils peuvent avoir un impact négatif sur les comportements diurnes. Par ailleurs, ils entrainent souvent des difficultés au sein de la famille. La prise en charge doit avant tout prendre en compte le contexte environnemental afin d’améliorer les habitudes et l’hygiène du sommeil. Des questionnaires ainsi que des agendas de sommeil ont été remplis par des parents afin de démontrer l’importance d’une évaluation et d’une prise en compte des troubles du sommeil chez les enfants souffrant d’autisme en consultation pédopsychiatrique. [less ▲]

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See detailFace à l'incertitude : la cristallisation des réseaux par les comédiens entrepreneurs
Pirard, Julie; Dufays, Frédéric; Xhauflair, Virginie ULiege

in Revue de l'Entrepreneuriat (in press)

A l’instar de l’action entrepreneuriale, la carrière de comédien est empreinte d’incertitude. Cet article examine comment les comédiens cristallisent leurs réseaux socio-professionnels pour réduire cette ... [more ▼]

A l’instar de l’action entrepreneuriale, la carrière de comédien est empreinte d’incertitude. Cet article examine comment les comédiens cristallisent leurs réseaux socio-professionnels pour réduire cette incertitude. L’analyse du parcours de quatre comédiens entrepreneurs révèle trois modulations de cristallisation – cristallisations et décristallisations successives, cristallisation d’un collectif ou d’une équipe, et cristallisation du réseau de partenaires – qui sont utilisées tantôt successivement, tantôt en combinaison. Ces cristallisations prennent forme autour d’une diversité d’éléments cristallisateurs, dépassant une vision exclusivement centrée sur un projet ou une personne. Ces résultats enrichissent le modèle réticulaire de création organisationnelle de Larson et Starr (1993), lui donnant un caractère plus systémique, et contribuent à la compréhension des processus d’insertion socio-professionnelle des artistes grâce au prisme de l’entrepreneuriat. [less ▲]

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See detail"'Vive la rose' in Newfoundland: from Alien to Emblem'
Peere, Isabelle ULiege

in B·A·S·I·S: Ballads and Songs - International Studies (in press)

This paper traces the song in European tradition through to its ‘revival’ in the 1960s. It analyses Emile’ Benoît's textual and musical recreation of it in the light of my own and other fieldworkers’ ... [more ▼]

This paper traces the song in European tradition through to its ‘revival’ in the 1960s. It analyses Emile’ Benoît's textual and musical recreation of it in the light of my own and other fieldworkers’ accounts of his personality, ethos and creative talent in tradition. The study traces the song's course and progress in Newfoundland, following in the steps of French-Canadian ethno-historian Ronald Labelle’s suggestion that ‘Vive la Rose’ has come to function as identity emblem for Newfoundland’s francophone minority – and even as its representative throughout French-Canada and especially Acadia. [less ▲]

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See detailInefficacy of autologous bone marrow concentrate in stage three osteonecrosis: a randomized controlled double-blind trial
HAUZEUR, Jean-Philippe ULiege; De Maertelaer, Viviane ; BAUDOUX, Etienne ULiege et al

in International Orthopaedics (in press)

Purpose The fracture stage of non-traumatic osteonecrosis (ON stage 3) of the femoral head (ONFH) has an unfavourable prognosis frequently requiring total hip replacement (THR). The percentage could be ... [more ▼]

Purpose The fracture stage of non-traumatic osteonecrosis (ON stage 3) of the femoral head (ONFH) has an unfavourable prognosis frequently requiring total hip replacement (THR). The percentage could be lowered after core decompression. In earlier non-fracture ON stages, implantation of autologous bone marrow aspirate concentrate (BMAC) improved the effect of core decompression. The purpose was to evaluate the effect of BMAC in addition to core decompression in stage 3 ONFH. Methods A double blind RCT was conducted comparing two groups: core decompression plus saline injection or core decompression plus BMAC implantation. Both patients and assessors were blinded to the treatment assignments. Evaluations were done at baseline, three, six, 12, and 24 months, including pain (VAS), WOMAC, side-effects, radiological evolution including ARCO subclassifications, together with possible THR requirement. The primary endpoint was the need for THR. The second endpoints included the clinical symptoms such as pain and functional ability and the progression of the ON lesions as well as the appearance of osteoarthritis features (ARCO stage 4). Both groups included 23 hips (19 patients). Results No differences were found between the groups for THR requirements, clinical tests, and radiological evolution. In both groups, 15/23 hips needed THR. The radiological evolution of the ONFH lesions in term of location, extension, surface collapse, and dome depression was moderate in both groups and was not correlated with the need of THR. Conclusions Implantation of BMAC after core decompression did not produce any improvement of the evolution of ONFH stage 3. [less ▲]

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See detailTraduction de "Sense and Its Place in Meaning" de W.V.O. Quine
Moreau, Timothée ULiege

in Philosophie (in press)

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See detailThe titanosaurian dinosaur Atsinganosaurus velauciensis (Sauropoda) from the Upper Cretaceous of southern France: new material, phylogenetic affinities, and palaeobiogeographical implications
Díez Díaz, Verónica; Garcia, Géraldine; Pereda Suberbiola, Xavier et al

in Cretaceous Research (in press)

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See detailEducation and Outreach by the Antarctic Treaty Parties, Observers and Experts under the framework of the Antarctic Treaty Consultative meetings
Xavier, José C; Mateev, Dragomir; Capper, linda et al

in Polar Record (in press)

The development of formal discourse about education and outreach within the Antarctic Treaty Consultative Meetings (ATCM), and the influence of major international activities in this field, are described ... [more ▼]

The development of formal discourse about education and outreach within the Antarctic Treaty Consultative Meetings (ATCM), and the influence of major international activities in this field, are described. We reflect on the ATCM Parties’ approach to implementing the ambition of the Protocol on Environmental Protection to the Antarctic Treaty Article 6.1.a, to promote the educational value of Antarctica and its environment, and we examine the role of workshops and expert groups within the Scientific Committee on Antarctic Research (SCAR), the International Union for the Conservation of Nature (IUCN), and the Council of Managers of National Antarctic Programmes, that emerged in the 1990s, in stimulating discussion within the ATCM. These early initiatives were a prelude to the development and implementation of a large number of International Polar Year (IPY) education and outreach programmes. The establishment of an Antarctic Treaty System Intersessional Contact Group, and an on-line forum on education and outreach during the 2015 ATCM in Bulgaria, is a legacy of IPY and is the next step in fostering collaboration to engage people around the world in the importance and relevance of Antarctica to our daily lives. [less ▲]

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See detailClassic Vulvar Intraepithelial Neoplasia With Superimposed Lichen Simplex Chronicus: A Unique Variant Mimicking Differentiated Vulvar Intraepithelial Neoplasia.
Watkins, Jaclyn; Yang, Eric; Crum, Christopher et al

in International Journal of Gynecological Pathology (in press)

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See detailHow different serols contribute to cytotoxic action of sea cucumber saponins
Claereboudt, Emily ULiege; Eeckhaut, Igor; Lins, Laurence ULiege et al

in Scientific Reports (in press)

Sea cucumbers produce saponins as a chemical defense mechanism, however their cells can tolerate the cytotoxic nature of these chemicals. To elucidate the molecular mechanisms behind this tolerance a ... [more ▼]

Sea cucumbers produce saponins as a chemical defense mechanism, however their cells can tolerate the cytotoxic nature of these chemicals. To elucidate the molecular mechanisms behind this tolerance a suite of complementary biophysical tools was used, firstly using liposomes for in vitro techniques then using in silico approaches for a molecular-level insight. The holothuroid saponin Frondoside A, caused significantly less permeabilization in liposomes containing a Δ7 holothuroid sterol than those containing cholesterol and resulted in endothermic interactions versus exothermic interactions with cholesterol containing liposomes. Lipid phases simulations revealed that Frondoside A has an agglomerating effect on cholesterol domains, however, induced small irregular Δ7 sterol clusters. Our results suggest that the structural peculiarities of holothuroid sterols provide sea cucumbers with a mechanism to mitigate the sterol-agglomerating effect of saponins, and therefore to protect their cells from the cytotoxicity of the saponins they produce. [less ▲]

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See detailThe time to remember: temporal compression and duration judgements in memory for real-life events
Jeunehomme, Olivier ULiege; D'Argembeau, Arnaud ULiege

in Quarterly Journal of Experimental Psychology (in press)

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