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See detailUn regard post-coloniliste de la médiatisation européenne à l'heure des Femen en Tunisie
Luceno Moreno, Marta ULiege

in Open Library of Humanities (in press)

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See detailRevue systématique des essais consacrés aux traitements psycho-comportementaux de l’éjaculation prématurée
Kempeneers, Philippe ULiege

in Sexologies: Revue Européenne de Santé Sexuelle (in press)

Objective. The aim of this review is to draw general lessons from several decades of empirical research on psycho-behavioural treatments for premature ejaculation. Method. Thirty-three trials reporting ... [more ▼]

Objective. The aim of this review is to draw general lessons from several decades of empirical research on psycho-behavioural treatments for premature ejaculation. Method. Thirty-three trials reporting measures pre- and post-sex therapy were collected and assessed. Results. The improvement rates associated with sex therapies ranged from 25% to 100%, the overall effect size (d) was between 0.83 and 3.75. The effectiveness of the interventions requires penile stimulation exercises with pauses ("stop-start") and/or exercises aimed at regulating discrete components of sexual arousal ("regulatory" or "sexual-functional" approach). It is not clear whether variations involving squeezing, use of a vibratory device or a particular mode of masturbation are more effective. Exercises that focus on strengthening the pelvic muscles do not appear to be particularly effective. The most effective treatments are also those that allow for support of the beneficiaries in order to ensure an adequate integration of the therapeutic principles and to address any associated difficulties. In this respect, self-treatment formulas appear less effective. The combination of sex therapy and drug therapy generally yields better results than either of these two options alone. Conclusions. Empirical research accumulated over several decades supports the usefulness of sex therapies in the field of premature ejaculation and specifies their conditions of effectiveness. [less ▲]

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See detailStatistics and linguistics: can we tell something more about Pliny the Elder?
Fantoli, Margherita ULiege

in Classics@ (in press)

Présentation des outils et des méthodes L.A.S.L.A. et discussion des premiers résultats des tests statistiques sur le deuxième livre de la Naturalis Historia de Pline l'Ancien.

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See detailAn Annual Wealth Tax: Pros and Cons
Pestieau, Pierre ULiege; Boadway, Robin

in Finanz-Archiv (in press)

We explore the case for a wealth tax as part of the tax mix. Annual wealth taxes are roughly equivalent to capital income taxes on the assets to which they apply. Wealth taxes differ in purpose from ... [more ▼]

We explore the case for a wealth tax as part of the tax mix. Annual wealth taxes are roughly equivalent to capital income taxes on the assets to which they apply. Wealth taxes differ in purpose from inheritance taxes which are useful adjuncts to income taxes. We recount the arguments for taxing capital income, and for taxing inheritances regardless of whether capital income is taxed. We argue that if the desire to tax asset income and wealth transfers is appropriately addressed by capital income and inheritance taxation, the additional need for an annual wealth tax is minimal. [less ▲]

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See detailAgeism among psychology students: A comparative analysis between Belgium and Quebec (Canada)
Marquet, Manon ULiege; Vallet, Guillaume; Adam, Stéphane ULiege et al

in Année Psychologique (in press)

This study aimed to examine ageist attitudes in psychology students who may become the healthcare professionals. We also compared cultural differences between attitudes in Belgium and Quebec. We ... [more ▼]

This study aimed to examine ageist attitudes in psychology students who may become the healthcare professionals. We also compared cultural differences between attitudes in Belgium and Quebec. We hypothesized that psychology students would have more positive attitudes toward older people in Quebec than in Belgium. Quebec has indeed more invested in age-friendly initiatives that may promote socio-economic factors associated with better attitudes toward older people. A total of 236 psychology students participated in this study (81 Belgian students and 155 Quebec students). The students completed different self-reported questionnaires to assess their attitudes toward older people. As predicted, the results showed that students in Quebec were overall less negative toward older adults. Since negative attitudes may influence students’ choice to work with older people and may also have damaging consequences in the assessment and/or healing context, we discuss different directions to improve these attitudes. [less ▲]

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See detailPrimary immune thrombocytopenia in adults. Belgian recommendations for diagnosis and treatment anno 2021 made by the Belgian Hematology Society
Janssens, A.; Selleslag, Dominik; Depaus, J. et al

in Acta Clinica Belgica (in press)

The Belgian Hematology Society (BHS) updated the 2013 guidelines for diagnosis and treatment of primary immune thrombocytopenia (ITP) [1]. As knowledge about ITP pathophysiology is increasing, the mode of ... [more ▼]

The Belgian Hematology Society (BHS) updated the 2013 guidelines for diagnosis and treatment of primary immune thrombocytopenia (ITP) [1]. As knowledge about ITP pathophysiology is increasing, the mode of action of old therapies is better understood and novel drugs are introduced to target more specific pathways. Corticosteroids with or without intravenous immunoglobulins (IgIV) remain the first-line treatment. According to the updated international guidelines a short course of corticosteroids rather than a prolonged treatment has to be recommended. The same guidelines stress that consequent therapies as thrombopoietic agents (TPO-RAs) and rituximab should be available independent of duration of ITP. Although the majority of recommendations is based on very low-quality evidence, it is strongly advised to individualize the ITP management taking patient values. and preferences in account. The main treatment goal in all ITP patients must be to maintain a safe platelet count to prevent or stop bleeding with a minimum of toxicity and not to normalize the platelet count. [less ▲]

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See detailOdanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicenter, randomized, double-blind, placebo-controlled trial and LOFT Extension Study
McClung, M.R.; O'Donoghue, M.L.; Papapoulos, S.E. et al

in Lancet Diabetes and Endocrinology (in press)

Background: Odanacatib, a cathepsin K inhibitor, reduces bone resorption while maintaining bone formation. Previous work has shown that odanacatib increases bone mineral density in postmenopausal women ... [more ▼]

Background: Odanacatib, a cathepsin K inhibitor, reduces bone resorption while maintaining bone formation. Previous work has shown that odanacatib increases bone mineral density in postmenopausal women with low bone mass. We aimed to investigate the efficacy and safety of odanacatib to reduce fracture risk in postmenopausal women with osteoporosis. Methods: The Long-term Odanacatib Fracture Trial (LOFT) was a multicentre, randomised, double-blind, placebocontrolled, event-driven study at 388 outpatient clinics in 40 countries. Eligible participants were women aged at least 65 years who were postmenopausal for 5 years or more, with a femoral neck or total hip bone mineral density T-score between –2·5 and –4·0 if no previous radiographic vertebral fracture, or between –1·5 and –4·0 with a previous vertebral fracture. Women with a previous hip fracture, more than one vertebral fracture, or a T-score of less than –4·0 at the total hip or femoral neck were not eligible unless they were unable or unwilling to use approved osteoporosis treatment. Participants were randomly assigned (1:1) to either oral odanacatib (50 mg once per week) or matching placebo. Randomisation was done using an interactive voice recognition system after stratification for previous radiographic vertebral fracture, and treatment was masked to study participants, investigators and their staff, and sponsor personnel. If the study completed before 5 years of double-blind treatment, consenting participants could enrol in a double-blind extension study (LOFT Extension), continuing their original treatment assignment for up to 5 years from randomisation. Primary endpoints were incidence of vertebral fractures as assessed using radiographs collected at baseline, 6 and 12 months, yearly, and at final study visit in participants for whom evaluable radiograph images were available at baseline and at least one other timepoint, and hip and non-vertebral fractures adjudicated as being a result of osteoporosis as assessed by clinical history and radiograph. Safety was assessed in participants who received at least one dose of study drug. The adjudicated cardiovascular safety endpoints were a composite of cardiovascular death, myocardial infarction, or stroke, and new-onset atrial fibrillation or flutter. Individual cardiovascular endpoints and death were also assessed. LOFT and LOFT Extension are registered with ClinicalTrials.gov (number NCT00529373) and the European Clinical Trials Database (EudraCT number 2007-002693-66). Findings: Between Sept 14, 2007, and Nov 17, 2009, we randomly assigned 16 071 evaluable patients to treatment: 8043 to odanacatib and 8028 to placebo. After a median follow-up of 36·5 months (IQR 34·43–40·15) 4297 women assigned to odanacatib and 3960 assigned to placebo enrolled in LOFT Extension (total median follow-up 47·6 months, IQR 35·45–60·06). In LOFT, cumulative incidence of primary outcomes for odanacatib versus placebo were: radiographic vertebral fractures 3·7% (251/6770) versus 7·8% (542/6910), hazard ratio (HR) 0·46, 95% CI 0·40–0·53; hip fractures 0·8% (65/8043) versus 1·6% (125/8028), 0·53, 0·39–0·71; non-vertebral fractures 5·1% (412/8043) versus 6·7% (541/8028), 0·77, 0·68–0·87; all p<0·0001. Combined results from LOFT plus LOFT Extension for cumulative incidence of primary outcomes for odanacatib versus placebo were: radiographic vertebral fractures 4·9% (341/6909) versus 9·6% (675/7011), HR 0·48, 95% CI 0·42–0·55; hip fractures 1·1% (86/8043) versus 2·0% (162/8028), 0·52, 0·40–0·67; non-vertebral fractures 6·4% (512/8043) versus 8·4% (675/8028), 0·74, 0·66–0·83; all p<0·0001. In LOFT, the composite cardiovascular endpoint of cardiovascular death, myocardial infarction, or stroke occurred in 273 (3·4%) of 8043 patients in the odanacatib group versus 245 (3·1%) of 8028 in the placebo group (HR 1·12, 95% CI 0·95–1·34; p=0·18). New-onset atrial fibrillation or flutter occurred in 112 (1·4%) of 8043 patients in the odanacatib group versus 96 (1·2%) of 8028 in the placebo group (HR 1·18, 0·90–1·55; p=0·24). Odanacatib was associated with an increased risk of stroke (1·7% [136/8043] vs 1·3% [104/8028], HR 1·32, 1·02–1·70; p=0·034), but not myocardial infarction (0·7% [60/8043] vs 0·9% [74/8028], HR 0·82, 0·58–1·15; p=0·26). The HR for all-cause mortality was 1·13 (5·0% [401/8043] vs 4·4% [356/8028], 0·98–1·30; p=0·10).When data from LOFT Extension were included, the composite of cardiovascular death, myocardial infarction, or stroke occurred in significantly more patients in the odanacatib group than in the placebo group (401 [5·0%] of 8043 vs 343 [4·3%] of 8028, HR 1·17, 1·02–1·36; p=0·029, as did stroke (2·3% [187/8043] vs 1·7% [137/8028], HR 1·37, 1·10–1·71; p=0·0051). Interpretation: Odanacatib reduced the risk of fracture, but was associated with an increased risk of cardiovascular events, specifically stroke, in postmenopausal women with osteoporosis. Based on the overall balance between benefit and risk, the study’s sponsor decided that they would no longer pursue development of odanacatib for treatment of osteoporosis. [less ▲]

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See detailContact Pressure Between the Vocal Folds in Reinke’s Edema: Experimental Observations on an Excised Human Larynx
SILVA, FABRICE; LEGOU, THIERRY; CHAMPSAUR, PIERRE et al

in Journal of Voice (in press)

Objective. To analyze the range of values of the contact pressure between the membranous vocal folds with Reinke’s edema and to compare it to those observed in the absence of such a lesion. Methods. Two ... [more ▼]

Objective. To analyze the range of values of the contact pressure between the membranous vocal folds with Reinke’s edema and to compare it to those observed in the absence of such a lesion. Methods. Two human larynges were separately tested on the experimental bench, one of them with a bilateral loose swelling of the vocal folds. Once in a glottal prephonatory configuration, airflow was increased until achievement of self-sustained oscillations while recording aerodynamic, acoustic, electroglottographic data, and contact pressure between the folds. Results. We observed well-documented variations in acoustical parameters, as the decrease of the fundamental frequency and the increase of the phonation threshold pressure. The results of the study also point to a significant increase in the amplitude of the contact pressure in presence of the Reinke’s edema, and a lower degree of harmonicity of the produced sounds. Conclusion. This is the first report of ex vivo study of a larynx with Reinke’s edema. It highlights the increase in the contact pressure during phonation, which possibly contributes to sustain the lesion once it appeared. [less ▲]

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See detailLa question de l’éducation : aiguillon des philosophies politiques. Castoriadis/Rancière.
Wustefeld, Sophie ULiege

in MethIS: Méthodes et Interdisciplinarité en Sciences Humaines (in press)

La démocratie reste un thème chéri par la philosophie politique contemporaine, pour l’écart entre ses théories et ses pratiques, pour la distance critique que ses théories offrent vis-à-vis des régimes ... [more ▼]

La démocratie reste un thème chéri par la philosophie politique contemporaine, pour l’écart entre ses théories et ses pratiques, pour la distance critique que ses théories offrent vis-à-vis des régimes démocratiques et de leur évolution, mais aussi parce qu’elle est un objet perpétuel de dissensus entre philosophes, au sujet duquel toute prétention à la véridiction est suspendue à sa réalisation pratique. À ce titre, la transmission de la volonté démocratique est un topos houleux de la philosophie politique contemporaine. Cette question catalyse les concepts pivots des philosophies politiques, la leur poser permet de mieux saisir les enjeux rivaux derrière une terminologie commune à plusieurs auteurs. C’est dans cette démarche que je vous propose d’examiner en miroir les philosophies de Cornélius Castoriadis et de Jacques Rancière. De plus en plus nombreux, des commentateurs rapprochent leurs pensées , qui peuvent s’appuyer sur plusieurs points communs : un attachement au concept de démocratie brandit contre les régimes parlementaires, une opposition contemporaine (quoique depuis des héritages différents) aux thèses défendues par Althusser, et une proximité de sources d’inspirations : la philosophie, le marxisme, et la psychanalyse. Partant de la manière dont cette proximité s’exprime dans la disjonction que chacun opère entre démocratie et science, je tenterai de discerner comment les inflexions qu’ils impriment aux concepts de volonté et d’égalité sous la guise des enjeux de la transmission dessinent des horizons politiques distincts, et dénotent des compréhensions antithétiques – mais indécidables dans la théorie – de ce que peut être la démocratie. [less ▲]

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See detailNotes sur la réception culturelle du char dans l’Egypte ancienne, § 1. Les talatates 29/137, 29/358 et 27/45 du IXe pylône de Karnak
Pietri, Renaud ULiege

in Cahiers de Karnak (in press), 17

A discussion about ceremonial chariots mentioned in three previously unpublished talatates from the IXth pylon in Karnak.

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See detailCost-Effectiveness Assessment of Different Glucosamines in Patients with Knee Osteoarthritis: A Simulation Model Adapted to Germany
Bruyère, Olivier ULiege; Detilleux, Johann ULiege; Reginster, Jean-Yves ULiege

in Current Aging Science (in press)

Abstract: Background: The use of symptomatic slow-acting drugs for osteoarthritis (OA) (e.g., glucosamine, chondroitin) is largely debated in the scientific literature. Indeed, multiple formulations of ... [more ▼]

Abstract: Background: The use of symptomatic slow-acting drugs for osteoarthritis (OA) (e.g., glucosamine, chondroitin) is largely debated in the scientific literature. Indeed, multiple formulations of these agents are available, both as pharmaceutical-grade products and as nutritional supplements, but while all preparations may claim to deliver a therapeutic effect, not all are supported by clinical evidence. Moreover, few data are available regarding the cost-effectiveness of all these formulations. Usually, access to individual patient data is required to perform economic evaluations of treatments, but it can be challenging to obtain. We previously developed a model to simulate individual health utility scores from aggregated data obtained from published OA trials. Objective: In the present study, using our new simulation model, we investigated the costeffectiveness of different glucosamines used in Germany. Methods: We used our validated model to simulate the utility scores of 10 published trials that used different glucosamine preparations. Using the simulated utility scores, the quality-adjusted life years (QALYs) were calculated using the area-under-the-curve method. We used the 2018 public costs of glucosamine products available in Germany to calculate the Incremental Cost/Effectiveness Ratio (ICER). We performed analyses for pharmaceutical-grade Crystalline Glucosamine Sulfate (pCGS) and other formulations of glucosamine (OFG). A cost-effectiveness cut-off of 30,000 €/QALY was considered. Results: Of 10 studies in which utility was simulated, four used pCGS, and six used OFG. The ICER analyses showed that pCGS was cost-effective compared to a placebo, with an ICER of 4489 €/QALY at month 3, 4112 €/QALY at month 6, and 9983 €/QALY at year 3. The use of OFG was not cost-effective at any of the time points considered. Conclusion: Using our previously published model to simulate the individual health utility scores of patients, we showed that, in the German context, the use of pCGS could be considered costeffective, while the use of OFG could not. These results highlight the importance of the formulation of glucosamine. [less ▲]

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See detailPresumptive acute myeloid leukemia in a Pelomedusa subrufa turtle
Melin, Marie; Vlaemynck, Frederic; Skeldon, Niki et al

in Veterinary Clinical Pathology (in press)

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See detailL’œil du cycle. Réseaux textuels et stemmata codicum dans la tradition des textes arthuriens
Morato, Nicola ULiege

in Encomia : Bulletin Bibliographique de la Société Internationale de Littérature Courtoise (in press)

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See detailDie acht Briefe der Rückseite des 'Rotulus von Ravenna'. Eine Briefsammlung zu Erzbischof Johannes von Ravenna (905-914)
Rozein, Matthias ULiege

in Archiv für Kulturgeschichte (in press)

Zu Beginn des 10. Jahrhunderts wurden acht Briefe auf die Rückseite des 1882 entdeckten ‚Rotulus von Ravenna‘ niedergeschrieben: Sieben haben Erzbischof Johannes von Ravenna (905–914), den zukünftigen ... [more ▼]

Zu Beginn des 10. Jahrhunderts wurden acht Briefe auf die Rückseite des 1882 entdeckten ‚Rotulus von Ravenna‘ niedergeschrieben: Sieben haben Erzbischof Johannes von Ravenna (905–914), den zukünftigen Papst Johannes X. (914–928), einer Papst Sergius III. (904–911) zum Autor. In der Forschung wurden diese Schreiben bisher ausschließlich als einzelne Dokumente wahrgenommen. Der folgende Aufsatz verfolgt das Ziel, die Briefe erstmals in ihrer Gesamtheit zu betrachten, als Briefsammlung deren einzelne Teile bewusst ausgewählt und angeordnet wurden. Dazu wird zunächst das schwierige Verhältnis zwischen der Datierung der Briefe und ihrer Platzierung auf der Rolle behandelt: Die Argumente, die bisher für eine stringent chronologische Anordnung der Briefe angeführt wurden, sind nämlich nicht stichhaltig. Gleichzeitig können jedoch keine Faktoren ausgemacht werden, die eine präzise Datierung ermöglichen würden. Anschließend wird die Ausrichtung der Sammlung näher betrachtet. In sämtlichen Briefen tritt Johannes als unermüdlicher Verteidiger der Kirche von Ravenna in Erscheinung. Darüber hinaus ist die Abfolge der Schreiben geprägt von der Bedeutungssteigerung der verschiedenen Personen, mit denen Johannes in Kontakt tritt. Die Sammlung trägt somit dazu bei, den Erzbischof als prominente und gut vernetzte Persönlichkeit darzustellen, stets darum bemüht, die Position seiner ihm anvertrauten Kirche zu festigen. Schließlich werden auch einige Überlegungen zum Entstehungskontext formuliert, die auch auf das besondere Überlieferungsformat dieser Briefsammlung eingehen. [less ▲]

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See detailL'idée d'égalité chez Émile de Laveleye
Grandjean, Geoffrey ULiege

in Revue Belge de Philologie et d'Histoire (in press), 4

Émile de Laveleye (1822-1892), juriste de formation, fut professeur d’économie politique à l’Université de Liège. Il a notamment publié de nombreux écrits sur l’organisation du système politique belge ... [more ▼]

Émile de Laveleye (1822-1892), juriste de formation, fut professeur d’économie politique à l’Université de Liège. Il a notamment publié de nombreux écrits sur l’organisation du système politique belge. Cet article précise la place occupée par l’idée d’égalité dans ses écrits, à partir d’un matériau constitué de 43 de ces textes. Après avoir identifié les causes qui fondent, selon Émile de Laveleye, les inégalités au sein d’un système politique, cet article analyse la manière dont il souhaite concrétiser l’idée d’égalité, à travers son rapport à la liberté, à l’instruction et au suffrage universel et à la promotion des idées socialistes. [less ▲]

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See detailReducibility of n-ary semigroups: from quasitriviality towards idempotency
Couceiro, Miguel; Devillet, Jimmy; Marichal, Jean-Luc et al

in Beiträge zur Algebra und Geometrie (in press)

Let $X$ be a nonempty set. Denote by $\mathcal{F}^n_k$ the class of associative operations $F\colon X^n\to X$ satisfying the condition $F(x_1,\ldots,x_n)\in\{x_1,\ldots,x_n\}$ whenever at least $k$ of the ... [more ▼]

Let $X$ be a nonempty set. Denote by $\mathcal{F}^n_k$ the class of associative operations $F\colon X^n\to X$ satisfying the condition $F(x_1,\ldots,x_n)\in\{x_1,\ldots,x_n\}$ whenever at least $k$ of the elements $x_1,\ldots,x_n$ are equal to each other. The elements of $\mathcal{F}^n_1$ are said to be quasitrivial and those of $\mathcal{F}^n_n$ are said to be idempotent. We show that $\mathcal{F}^n_1=\cdots =\mathcal{F}^n_{n-2}\subseteq\mathcal{F}^n_{n-1}\subseteq\mathcal{F}^n_n$ and we give conditions on the set $X$ for the last inclusions to be strict. The class $\mathcal{F}^n_1$ was recently characterized by Couceiro and Devillet \cite{CouDev}, who showed that its elements are reducible to binary associative operations. However, some elements of $\mathcal{F}^n_n$ are not reducible. In this paper, we characterize the class $\mathcal{F}^n_{n-1}\setminus\mathcal{F}^n_1$ and show that its elements are reducible. We give a full description of the corresponding reductions and show how each of them is built from a quasitrivial semigroup and an Abelian group whose exponent divides $n-1$. [less ▲]

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See detailBrentano and the ideality of time
Seron, Denis ULiege

in Revista de Filosofia Moderna e Contemporânea (in press), 9(2),

How is it possible to have present memory experiences of things that, being past, are no longer presently experienced? A possible answer to this long-standing philosophical question is what I call the ... [more ▼]

How is it possible to have present memory experiences of things that, being past, are no longer presently experienced? A possible answer to this long-standing philosophical question is what I call the “ideality of time view,” namely the view that temporal succession is unreal. In this paper I outline the basic idea behind Brentano’s version of the ideality of time view. Additionally, I contrast it with Hume’s version, suggesting that, despite significant differences, it can nonetheless be construed as broadly Humean. [less ▲]

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See detailDoping dependent phase fractions in hydrothermally synthesized Mn doped CuFeO2
Igbinehi, Neslon; Mahmoud, Abdelfattah ULiege; Fenske, Daniela et al

in Physica Status Solidi A: Applications and Materials Science (in press)

Using a simple hydrothermal method, CuFe1−xMnxO2 delafossite materials are produced and investigated by means of X-ray diffraction, ultraviolet-visible reflectance measurements, and electron microscopy ... [more ▼]

Using a simple hydrothermal method, CuFe1−xMnxO2 delafossite materials are produced and investigated by means of X-ray diffraction, ultraviolet-visible reflectance measurements, and electron microscopy. Up to nominally x = 0.3, the synthesis yields delafossite material, which generally consists of both the 2H and R3 phase without any impurities. Lattice parameters and the indirect optical band gap of delafossite close to about 1.3 eV decrease upon increasing Mn content, which confirms the successful doping with Mn up to an actual Mn content of x = 0.05. The 2H phase fraction shows a pronounced and peaked dependence on Mn content with a maximum 2H mass fraction of about 27% at nominally x = 0.01, whereas the hexagonal particle morphology and the platelet size of about 500 nm as measured by both scanning and transmission electron microscopy are independent from the latter. [less ▲]

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See detailPRISE EN CHARGE CHIRURGICALE DE LA MALADIE D’OTTO CHEZ L’ENFANT
Kabore, Christophe ULiege; Allington, Nanni ULiege

in Ortho-Rhumato (in press)

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See detailFrailty but not sarcopenia nor malnutrition increases the risk of developing COVID-19 in older community-dwelling adults.
Lengele, Laetitia ULiege; Locquet, Médéa ULiege; Moutschen, Michel ULiege et al

in Aging clinical and experimental research (in press)

BACKGROUND: The identification of coronavirus disease 2019 (COVID-19) risk factors is requested to implement prevention strategies. AIM: To explore the associations between the COVID-19 incidence and ... [more ▼]

BACKGROUND: The identification of coronavirus disease 2019 (COVID-19) risk factors is requested to implement prevention strategies. AIM: To explore the associations between the COVID-19 incidence and malnutrition, sarcopenia, and frailty, identified as potential risk factors in previous cross-sectional studies. METHODS: Malnutrition, sarcopenia, and frailty were assessed at the last available follow-up from the Sarcopenia and Physical Impairments with Advancing Age (SarcoPhAge) cohort (i.e., the fifth year that ended in 2019) according to the Mini-Nutritional Assessment short-form, the European Working Group on Sarcopenia in Older People (EWGSOP2), and the Fried criteria, respectively. Information regarding the COVID-19 was gathered by phone calls interviews in April 2021 to measure its self-declared incidence. Adjusted Cox regressions and Kaplan-Meier curves were performed. RESULTS: The present study included 241 participants [median age 75.6 (73.0-80.6) years, 63.1% women]. Among them, 27 participants (11.2%) developed the non-fatal Covid-19. No significant increased risks of COVID-19 were observed in patients with malnutrition [adjusted HR 1.14 (0.26-5.07)] and sarcopenia [adjusted HR 1.25 (0.35-4.42)]. Nevertheless, the incidence of COVID-19 was significantly higher in frail (44.4%) than in robust participants (8.5%) [Adjusted HR 7.01 (2.69-18.25)], which was confirmed by the Kaplan-Meier curves (p < 0.001). Among the frailty syndrome components, a low physical activity level was the only one significantly associated with an increased risk of COVID-19 [adjusted HR 5.18 (1.37-19.54)]. CONCLUSION: Despite some limitations in the methodology of this study (i.e., limited sample size, COVID-19 incidence self-reported and not assessed systematically using objective measurements) requiring careful  consideration, an increased risk to develop COVID-19 was observed in the presence of the frailty syndrome. Further investigations are needed to elaborate on our findings. [less ▲]

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See detailLes critiques chrétiennes des lectisternes et sellisternes romains : un banquet trop anthropomorphe ?
Berthelet, Yann ULiege

in Les Cahiers du CEDOPAL (in press)

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See detailPrognostic value of a new clinically-based classification system in patients with CMML undergoing allogeneic HCT: a retrospective analysis of the EBMT-CMWP
Onida, Francesco; Sbianchi, Giulia; Radujkovic, Aleksandar et al

in Bone Marrow Transplantation (in press)

Recently a new 3-group clinical classification was reported by an International Consortium to stratify CMML patients with regard to prognosis. The groups were defined as follows: 1. Myelodysplastic (MD ... [more ▼]

Recently a new 3-group clinical classification was reported by an International Consortium to stratify CMML patients with regard to prognosis. The groups were defined as follows: 1. Myelodysplastic (MD)-CMML: WBC ≤10 x 109/L, circulating immature myeloid cells (IMC) = 0, no splenomegaly; 2. MD/MP (overlap) –CMML: WBC 10-20 x 109/L or WBC ≤10 x 109/L but IMC >0 and/or splenomegaly; 3. Myeloproliferative (MP)-CMML: WBC >20 x 109/L. By analysing EBMT Registry patients who underwent allo-HCT for CMML between 1997 and 2016, we aimed to determine the impact of this classification on transplantation outcome and to make a comparison with the conventional WHO classification (CMML-0/CMML-1/CMML-2). Patient grouping was based on the data registered at time of transplantation, with IMC replaced by peripheral blasts. Among 151 patients included in the analysis, 38% were classified as MD-CMML, 42% as MD/MP-CMML and 20% as MP-CMML. With a median survival of 17 months in the whole series, MD-CMML patients were distinguished as a low-risk group with higher CR rate at transplant and a longer post-transplant 2-year progression-free survival in comparison to others (44.5% vs 33.5%, respectively), whereas the WHO classification was superior in identifying high-risk patients (CMML-2) with inferior survival outcomes. [less ▲]

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See detailAberrations chromatiques : de l’émulsion au pixel
Thonon, Jonathan ULiege

in Cahiers Louis Lumière (in press)

Dans l’une de ses conversations avec Joachim Gasquet sur le sens de sa peinture (et de la peinture en général), Cézanne aborde de front la conception qu’il se fait de la couleur, dans son rapport à la ... [more ▼]

Dans l’une de ses conversations avec Joachim Gasquet sur le sens de sa peinture (et de la peinture en général), Cézanne aborde de front la conception qu’il se fait de la couleur, dans son rapport à la profondeur picturale et de son articulation à la surface : « La nature n'est pas en surface ; elle est en profondeur. Les couleurs sont l'expression, à cette surface, de cette profondeur. Elles montent des racines du monde ». Cet « organisme de couleurs » que constitue le monde est transcrit dans la peinture de Cézanne par une dynamique symbiotique de la couleur et du dessin, de la ligne et du pan. La couleur restitue, par sa masse, son surgissement, son homogénéité, presque sa viscosité, la véritable chaire perceptive du monde ; une vision qui tient à distance la perspective géométrique, photographique, cinématographique fondée sur la transparence et qui repose, comme le signale Merleau-Ponty, sur la « réversibilité des dimensions » (surface-profondeur) et l’entrelacement des choses. C’est cette épaisseur du visible rendu par la couleur que l’économie de l’image numérique nous permet de redécouvrir, moins dans le registre de la « tactilité » de l’image et la picturalité du pixel, que par l’intégration, entre le support et l’image (parfois indiscernables dans le régime optique), d’un « corps » algorithmique qui règle l’actualisation du visible. Certains défauts techniques du dispositif numérique, aujourd’hui élevés au rang de pratique artistique, permettent de révéler cette matrice qui utilise alors la couleur et la coulure comme mode de visibilité. C’est le cas du Datamoshing, technique de composition numérique qui revisite tout en la radicalisant la pratique de l’incrustation vidéo. Basée sur la perturbation volontaire d’éléments de la matrice, cette technique transforme les couleurs en une forme malléable et fluide révélant ainsi leur double nature spatiale : elles sont à la fois dans l’espace de l’image et l’espace de l’image lui-même. Ces expériences de défigurations d’images s’inscrivent dans le registre des « aberrations chromatiques » dont nous proposons ici une rapide généalogie avant d’interroger la couleur digitale dans ses spécificités. [less ▲]

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See detailPratiques éducatives parentales et premières compétences en numératie des enfants d’âge préscolaire selon le niveau socio-économique et culturel des familles
Poncelet, Débora; de Chambrier, Anne-Françoise; Tinnes-Vigne, Mélanie et al

in Revue Internationale de l'Education Familiale (in press)

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See detailA Connectivity-Based Psychometric Prediction Framework for Brain-Behavior Relationship Studies.
Wu, Jianxiao; Eickhoff, Simon B.; Hoffstaedter, Felix et al

in Cerebral cortex (New York, N.Y. : 1991) (in press)

The recent availability of population-based studies with neuroimaging and behavioral measurements opens promising perspectives to investigate the relationships between interindividual variability in brain ... [more ▼]

The recent availability of population-based studies with neuroimaging and behavioral measurements opens promising perspectives to investigate the relationships between interindividual variability in brain regions' connectivity and behavioral phenotypes. However, the multivariate nature of connectivity-based prediction model severely limits the insight into brain-behavior patterns for neuroscience. To address this issue, we propose a connectivity-based psychometric prediction framework based on individual regions' connectivity profiles. We first illustrate two main applications: 1) single brain region's predictive power for a range of psychometric variables and 2) single psychometric variable's predictive power variation across brain region. We compare the patterns of brain-behavior provided by these approaches to the brain-behavior relationships from activation approaches. Then, capitalizing on the increased transparency of our approach, we demonstrate how the influence of various data processing and analyses can directly influence the patterns of brain-behavior relationships, as well as the unique insight into brain-behavior relationships offered by this approach. [less ▲]

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See detailFormation, diffusion, analyse sémique et analyse distributionnelle des désignations du taureau en Wallonie. Les désignations belgoromanes du taureau sont-elles synonymes ?
Balthazard, Matthieu ULiege

in Dialectes de Wallonie (in press), 37

Cet article s’intègre dans un cadre plus large, celui de la rédaction de la notice TAUREAU de l’Atlas linguistique de la Wallonie, tome 11, consacré au vocabulaire de l’élevage. La notice TAUREAU se ... [more ▼]

Cet article s’intègre dans un cadre plus large, celui de la rédaction de la notice TAUREAU de l’Atlas linguistique de la Wallonie, tome 11, consacré au vocabulaire de l’élevage. La notice TAUREAU se fonde sur les matériaux de quatre questions de l’Enquête de Haust : q. 322 « la semaine prochaine, il faudra mener notre vache au taureau », q. 334 « Le taureau ; entraves qu’on lui met », q. 335 « la vache est en chaleur » (dans le contexte : ⸀désire le taureau⸣) et q. 336 « faire saillir la vache par le taureau ». La grande carte et une première version du tableau des formes ont été préparées par Marie-Thérèse Counet. Notre analyse poursuit trois objectifs. Elle vise dans un premier temps à identifier les types lexicaux relevés dans les quatre questions, à en retracer l’histoire (formation et diffusion spatiale) et, par voie de conséquence, à les ordonner dans le temps. Dans un deuxième temps, notre analyse cherche à déterminer finement les significations des types, par l’analyse de leurs contextes d’occurrence. En troisième lieu, notre analyse cherche à identifier les relations entre ces types et donc à répondre à la question suivante : ces types sont-ils des synonymes ?, des géosynonymes ? Se pencher sur ces questions mène subséquemment à une autre interrogation, à savoir celle de la délimitation (au moins partielle) de la notion de synonymie quand elle est envisagée dans le cadre de la géolinguistique. [less ▲]

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See detailSemantic knowledge constrains the processing of serial order information in working memory
Kowialiewski, Benjamin ULiege; Gorin, Simon; Majerus, Steve ULiege

in Journal of Experimental Psychology. Learning, Memory and Cognition (in press)

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See detailCritique as a practice: inquiring into "virtual fence" and the politics of embeddedness (submitted 2020)
Thoreau, François ULiege

in Engaging Science, Technology, and Society (in press)

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See detailBack to the Future: the Democracy of Yesterday and Tomorrow in the Speeches of the Rassemblement National and the Freiheitliche Partei Österreichs
Debras, François ULiege

in Journal of Contemporary European Studies (in press)

In France, the Rassemblement National and, in Austria, the Freiheitliche Partei Österreichs aim to “recover”, “restore” or “protect” democracy. In this article, I will study their use of the term ... [more ▼]

In France, the Rassemblement National and, in Austria, the Freiheitliche Partei Österreichs aim to “recover”, “restore” or “protect” democracy. In this article, I will study their use of the term “democracy” by focusing on its temporal dimension. Their discourse tells a story, that of a glorious past which should be revived. Adopting a critical discourse analysis approach, I will answer the following questions: what kind of temporality is conveyed by the term “democracy”?, and, if “democracy” is perceived as a “lost world”, then what vision do those politicians who support the ideology of the two political parties have of tomorrow’s “democracy”? I would maintain that whilst these parties present themselves as agents of a democratic renewal, their vision of “democracy” remains traditional, i.e. essentially representative and vertical. The term “direct democracy” is limited to particular subjects (the EU, immigration, international agreements) and these parties are critical of electoral reforms or new forms of participation. [less ▲]

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See detailCause atypique de boiterie chez l'enfant
Sauvant, Céline ULiege; Kaux, Jean-François ULiege; Gillot, Vincent

in Journal de Traumatologie du Sport (in press)

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See detailOpening an absolute majority. A typology of motivations for opening and selecting coalition partners
Grandjean, Geoffrey ULiege; Meens, Valentine

in Politics of the Low Countries (in press)

Following the municipal elections in the Walloon Region (Belgium) on 14 October 2018, 189 political groups won an absolute majority. Twenty-too of these decided not to exercise power alone, but to favour ... [more ▼]

Following the municipal elections in the Walloon Region (Belgium) on 14 October 2018, 189 political groups won an absolute majority. Twenty-too of these decided not to exercise power alone, but to favour the formation of an oversized coalition by integrating a minority partner. The aim of this article is to identify the motivations behind the formation of a local coalition when one of the partners has an absolute majority. Semi-structured interviews with mayors and leaders of political groups in these municipalities make it possible to identify the motivations for first the choice to open and second the choice of a minority partner. By distinguishing between necessary and supporting motivations, this article shows that the search for greater representation is a necessary motivation for the choice to open, whereas personal affinities and memories of the past are necessary motivations for choosing minority partners. By prioritising motivations, this article shows that some motivations support the necessary motivations without conditioning the negotiation of an oversized coalition. [less ▲]

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See detailAerodynamic instability of circular slender structures due to bistable flow activity
Benidir, Adel; Flamand, Olivier; Dimitriadis, Grigorios ULiege et al

in Structural Engineering International (in press)

Slender structures with circular cylindrical cross-sections are very common in civil engineering, industrial equipment and bridge engineering. Such long cylinders subjected to wind are columns, piles ... [more ▼]

Slender structures with circular cylindrical cross-sections are very common in civil engineering, industrial equipment and bridge engineering. Such long cylinders subjected to wind are columns, piles, long cables, chimney, pylons and others. They usually have smooth surfaces and their shape is supposed to be circular, at first glance. It has been observed that if long cables are subjected to wind load, an aerodynamic phenomenon that generates instability can be experienced. This phenomenon (called dry galloping) has been recently theorized to be linked to an unpredictable jump state occurring once the boundary layers of the circular cylinder changes from laminar to turbulent. With a non-stationary character, the force generated at the critical flow regime is named bi-stable activity. In this work, the birth of bi-stable flow activity around a circular cylinder made of High-Density Polyethylene is studied experimentally. The experiment consists of testing a real cable sheath equipped with a large number of pressure taps in a wind tunnel. The pressure pattern is linearly decomposed and geometric modes governing the bi-stable activity as a function of circularity defect are created. The results show that the energy of the non-stationary load observed at the critical flow regime depends strongly on the circularity defect. Furthermore, the inclination angle of 60° confers a significant increase in the energy of the bi-stable flow mode when an unsteady asymmetric reattachment event occurs. The paper also highlights the variability of the mean drag coefficient as a function of the macroscopic defect. [less ▲]

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See detailPotential of caffeic acid derivatives as antimalarial leads.
Degotte, Gilles ULiege; Pirotte, Bernard ULiege; Francotte, Pierre ULiege et al

in Letters in Drug Design and Discovery (in press)

Malaria remains one of the deadliest infectious disease in 2021. Indeed, this infection, mostly caused by a protozoon called Plasmodium falciparum, is responsible annually for more than 200 million cases ... [more ▼]

Malaria remains one of the deadliest infectious disease in 2021. Indeed, this infection, mostly caused by a protozoon called Plasmodium falciparum, is responsible annually for more than 200 million cases and around 400 000 related deaths, mainly in Africa. Despite the availability of efficient drugs, we observe an increase of patients since 2015, which could find its origin in development of resistances from the parasite but also from its vectors, Anopheles mosquitoes. Consequently, it is necessary to search for new alternative treatments. Polyphenols, and more precisely small phenolic acids, could represent a good starting point for new antimalarials. Indeed, these molecules, such as caffeic acid (1), exhibit several pharmacological activities and an interesting pharmacokinetic profile. Therefore, we have developed several small derivatives of this scaffold to define the potential pharmacophore responsible for the antiplasmodial properties. We have obtained a good to low activity on Plasmodium (IC50 = 16-241 µM) with selectivity against human cells, especially for small esters (2-6, SI > 3). These structures have highlighted the need of catechol and carboxyl moieties in the anti-Plasmodium effect. Unfortunately, none of them seemed sufficiently effective to become a new antimalarial, but they could be new leads for future development. [less ▲]

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See detailUnderstanding the Stable Components of Seasonality in the Size Effect
Fays, Boris ULiege; Hübner, Georges ULiege; Lambert, Marie ULiege

in Journal of Portfolio Management (in press), 48(7),

This paper employs a sequential portfolio sorting procedure, called DSN, to factor size characteristics into returns. This leads to narrower portfolios than the original Fama-French (FF) ‘small’ and ‘big’ ... [more ▼]

This paper employs a sequential portfolio sorting procedure, called DSN, to factor size characteristics into returns. This leads to narrower portfolios than the original Fama-French (FF) ‘small’ and ‘big’ SMB components. The DSN sorting uncovers a purely seasonal part of the global size premium, due to a January effect. The stocks that are common to the FF and DSN small cap portfolios are smaller and of lower quality than those that are only retained by the FF procedure. This phenomenon supports a “tax-loss-pruning” hypothesis, in which investors discard small cap stocks with the lowest quality around the year end for tax reasons. [less ▲]

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See detailFictions de l’œuvre. Projets et textes possibles dans les romans de la vie littéraire
Saint-Amand, Denis ULiege

in Cahiers ReMIX (in press)

Le monde des études littéraires a vu se développer, au cours de ces dernières années, une théorie des textes possibles qui confronte la réception traditionnelle des œuvres (c’est-à-dire la façon dont leur ... [more ▼]

Le monde des études littéraires a vu se développer, au cours de ces dernières années, une théorie des textes possibles qui confronte la réception traditionnelle des œuvres (c’est-à-dire la façon dont leur lecture se concrétise la plupart du temps et le commentaire qu’on en livre habituellement) à une réinvention de leur signification, tirant parti des impensés de la fiction, des non-dits, des interactions interrompues, des blancs, des inférences labiles et autres zones creuses du récit qui offrent des prises pour une renégociation herméneutique. À côté des réinventions herméneutiques des œuvres classiques, de l’approche génétique et du fantasme programmatique autour des productions perdues, la critique des textes possibles aurait tout à gagner à explorer un continent fictionnel, fructueux en termes d’œuvres en puissance et qui recèle d’indications sur l’évaluation des modes et tendances d’une époque émanant des représentations des écrivains eux-mêmes : les œuvres imaginaires qui n’existent qu’en tant qu’elles sont inscrites dans d’autres œuvres, qui en esquissent les contours, les présentent voire les citent. Celles-là sont au cœur de la présente enquête, menée à partir du corpus rassemblé dans la base de données du GREMLIN ; on interroge dans cette contribution la façon dont, par métonymie, elles contribuent à une représentation fictionnelle de la vie littéraire. [less ▲]

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See detailCurrent practice for safe return-to-play after lateral ankle sprain: A survey among French-speaking physicians
Aguilaniu, Aude ULiege; Croisier, Jean-Louis ULiege; Schwartz, Cédric ULiege et al

in Foot and Ankle Surgery (in press)

Background: Recommendations are available for assessment criteria for safe return-to-play (RTP) after a lateral ankle sprain. However, their current use among physicians is unknown. Methods: French ... [more ▼]

Background: Recommendations are available for assessment criteria for safe return-to-play (RTP) after a lateral ankle sprain. However, their current use among physicians is unknown. Methods: French-speaking physicians in Belgium, France and Switzerland were asked to complete an online survey and report their clinical assessment of selected RTP criteria. Results:The respondent sample (n = 109) included physicians with and without Sports Medicine education, varied level of experience and proportion of athletes in their practice population. Pain was the most selected criterion for safe RTP (90% of physicians), followed by ability to engage in functional tasks (82%), functional instability (73%), range of motion (61%), proprioception (47%), mechanical instability (39%), strength (38%) and swelling (31%). A low proportion of physicians use quantitative measures to assess these criteria (between 4% and 53%). Conclusions: A large proportion of physicians consider the recommended criteria for RTP decisions. However, physicians do not frequently use quantitative measures. [less ▲]

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See detail2021 revised algorithm for the management of knee osteoarthritis-the Chinese viewpoint.
Zhang, Zhiyi; Huang, Cibo; Cao, Yongping et al

in Aging clinical and experimental research (in press)

AIM: The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) algorithm for the management of knee osteoarthritis (OA) is available ... [more ▼]

AIM: The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) algorithm for the management of knee osteoarthritis (OA) is available worldwide from 2014, but in 2019 an update was published. Based on this algorithm, a Working Group (WG), including ESCEO members and Chinese experts, wished to see how the new ESCEO algorithm was perceived by Chinese experts in knee OA and how it was integrated into their clinical practice. METHODS: A WG was held between members of the international ESCEO task force and a group of Chinese experts. RESULTS: Non-pharmacological approach should be combined with pharmacological interventions. In step 1, symptomatic slow-acting drugs for osteoarthritis (SYSADOA) are the most important background drugs. Evidence, supported by high-quality research, is available only for crystalline glucosamine sulfate (pCGS) and chondroitin sulfate. Topical NSAIDs could be used as an additional option. In step 2, oral NSAIDs could be useful, but cardiovascular/renal/gastrointestinal profiles of the patients should be considered. Intra-articular hyaluronic acid and corticosteroids are alternative to oral NSAIDs, but the evidence is still limited. If steps 1 and 2 are not sufficient, weak opioids could be used. Overall, the conclusions of the ESCEO algorithm are accepted in China for products available in this country. The WG suggests the importance of economic studies, specifically made in China. CONCLUSION: This work provides evidence-based advice to establish a treatment algorithm in knee OA, for practical implementation in clinical practice in China. [less ▲]

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See detailSimulation-based framework to evaluate resistivity of cooling strategies in buildings against overheating impact of climate change
Rahif, Ramin ULiege; Hamdy, Mohamed; Homaei, Shabnam et al

in Building and Environment (in press)

Over the last decades overheating in buildings has become a major concern. The situation is expected to worsen due to the current rate of climate change. Many efforts have been made to evaluate the future ... [more ▼]

Over the last decades overheating in buildings has become a major concern. The situation is expected to worsen due to the current rate of climate change. Many efforts have been made to evaluate the future thermal performance of buildings and cooling technologies. In this paper, the term “climate change overheating resistivity” of cooling strategies is defined, and the calculation method is provided. A comprehensive simulation-based framework is then introduced, enabling the evaluation of a wide range of active and passive cooling strategies. The framework is based on the Indoor Overheating Degree (IOD), Ambient Warmness Degree (AWD), and Climate Change Overheating Resistivity (CCOR) as principal indicators allowing a multi-zonal approach in the quantification of indoor overheating risk and resistivity to climate change. To test the proposed framework, two air-based cooling strategies including a Variable Refrigerant Flow (VRF) unit coupled with a Dedicated Outdoor Air System (DOAS) (C01) and a Variable Air Volume (VAV) system (C02) are compared in six different locations/climates. The case study is a shoe box model representing a double-zone office building. In general, the C01 shows higher CCOR values between 2.04 and 19.16 than the C02 in different locations. Therefore, the C01 shows superior resistivity to the overheating impact of climate change compared to C02. The maximum CCOR value of 37.46 is resulted for the C01 in Brussels, representing the most resistant case, whereas the minimum CCOR value of 9.24 is achieved for the C02 in Toronto, representing the least resistant case. [less ▲]

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See detailLong-term stability of 25-hydroxyvitamin D: importance of the analytical method and of the patient matrix.
Cavalier, Etienne ULiege

in Clinical chemistry and laboratory medicine (in press)

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See detailAnalytical evaluation of the Nittobo Medical tartrate resistant acid phosphatase isoform 5b (TRACP-5b) EIA and comparison with IDS iSYS in different clinically defined populations.
Cavalier, Etienne ULiege; LUKAS, Pierre ULiege; DELANAYE, Pierre ULiege

in Clinical chemistry and laboratory medicine (in press)

OBJECTIVES: Tartrate-resistant acid phosphatase, isoform 5b (TRACP-5b) is a bone resorption marker not influenced by renal function or food intake. TRACP-5b can be measured with Nittobo Medical enzymatic ... [more ▼]

OBJECTIVES: Tartrate-resistant acid phosphatase, isoform 5b (TRACP-5b) is a bone resorption marker not influenced by renal function or food intake. TRACP-5b can be measured with Nittobo Medical enzymatic-immunoassay and IDS-iSYS automated immunoassay. We evaluated the Nittobo assay and established reference ranges for a Western-European population. We compared Nittobo and IDS results in different well-defined clinical populations. METHODS: We established the limits of detection and quantification (LOD-LOQ), linearity, imprecision and the reference ranges in 119 males, 50 women (<45 years) and 120 women (>60 years) for TRACP-5b with the Nittobo assay. We compared both assays in 30 hemodialyzed (HD), and 40 stage 3-5 patients suffering from chronic kidney disease (CKD), 40 patients suffering from rheumatoid arthritis and osteoporosis and 80 post-menopausal women. We measured TRACP-5b, β-crosslaps (β-CTX), bone alkaline phosphatase (B-ALP) and PTH in 20 hemodialyzed (HD) and 40 CKD patients. RESULTS: LOD and LOQ were 0.02 and 0.35 U/L. CV ranged from 8.3 to 4.3% (2/5 samples presenting CV > desirable CV). Method was linear up to of 11.3 U/L. Upper and lower limits of normality were 0.8-7.6 U/L in men, 0.9-4.7 U/L in women <45 and 0.9-7.1 U/L in women >60. The regression equation between the 2 methods was Nittobo = 1.13 (95% CI: 1.09-1.16) × iSYS - 0.4 (95% CI: -0.5; -0.3). TRACP-5b and b-ALP were in their respective reference ranges for most of CKD and HD patients. That was not the case for β-CTX, which increased with decreasing eGFR. CONCLUSIONS: Nittobo TRACP-5b presents interesting analytical features and a good concordance with IDS iSYS. These methods could thus potentially be harmonized. [less ▲]

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See detailFigurines satiriques de singes en calcaire peint
Pietri, Renaud ULiege

in Bulletin archéologique des Écoles françaises à l'étranger (in press)

Report about a quick survey in Magasin 25 at Deir el-Medina which allowed to locate and gather a total of 27 painted limestonefigurines belonging to the same corpus, i. e. ‘figurines depicting monkeys ... [more ▼]

Report about a quick survey in Magasin 25 at Deir el-Medina which allowed to locate and gather a total of 27 painted limestonefigurines belonging to the same corpus, i. e. ‘figurines depicting monkeys imitating human activities’, such as playing music or driving a chariot. Most of those figurines are known thanks to Bernard Bruyère’s notebooks and publications. All of them have been documented in 2021. The 'monkeys driving chariots' subcorpus will be published in details in a future article. [less ▲]

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See detailCharacterisation of Small-Scale Farming as an Engine of Agricultural Development in Mountainous South Kivu, Democratic Republic of Congo
Mulumeoderhwa Munyakazi, Fidèle ULiege; Maniriho, Aristide ULiege; Neema Ciza, Angélique ULiege et al

in Asian Journal of Agriculture and Rural Development (in press)

Mountainous South Kivu is an agro-pastoral zone in Democratic Republic of Congo where smallscale agriculture is predominant. Due to its location and potential, this region would contribute to the food ... [more ▼]

Mountainous South Kivu is an agro-pastoral zone in Democratic Republic of Congo where smallscale agriculture is predominant. Due to its location and potential, this region would contribute to the food security of the population of South Kivu and neighbouring territories. This research aimed to establish a characterisation of small-scale farming in this area in order to highlight the factors that differentiate farms. To achieve this objective, we adopted a holistic approach coupled with descriptive statistics, analysis of variance and student's t-test for data analysis. Data were collected from a purposive sample of 211 farmers in 2018 and 2019 respectively. The results revealed that the differentiation of farms is based on the number of plots per farm, the choice of production systems, the cropping system, the land tenure, the gross margin, the gross value added and the net farm income achieved at farm level. Therefore, solutions such as access to finance allowing farmers to diversify their production system, the restoration of security in rural areas, the rehabilitation of the existing and creation of new feeder roads, and the setting and promotion of very strong and dynamic farmers' structures would allow a significant development of agricultural activities in the study area. [less ▲]

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See detailAssessment of serum total 25-hydroxyvitamin D assays for Vitamin D External Quality Assessment Scheme (DEQAS) materials distributed at ambient and frozen conditions.
Sempos, Christopher T.; Williams, Emma L.; Carter, Graham D. et al

in Analytical and bioanalytical chemistry (in press)

The Vitamin D External Quality Assessment Scheme (DEQAS) distributes human serum samples four times per year to over 1000 participants worldwide for the determination of total serum 25-hydroxyvitamin D ... [more ▼]

The Vitamin D External Quality Assessment Scheme (DEQAS) distributes human serum samples four times per year to over 1000 participants worldwide for the determination of total serum 25-hydroxyvitamin D [25(OH)D)]. These samples are stored at -40 °C prior to distribution and the participants are instructed to store the samples frozen at -20 °C or lower after receipt; however, the samples are shipped to participants at ambient conditions (i.e., no temperature control). To address the question of whether shipment at ambient conditions is sufficient for reliable performance of various 25(OH)D assays, the equivalence of DEQAS human serum samples shipped under frozen and ambient conditions was assessed. As part of a Vitamin D Standardization Program (VDSP) commutability study, two sets of the same nine DEQAS samples were shipped to participants at ambient temperature and frozen on dry ice. Twenty-eight laboratories participated in this study and provided 34 sets of results for the measurement of 25(OH)D using 20 ligand binding assays and 14 liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods. Equivalence of the assay response for the frozen versus ambient DEQAS samples for each assay was evaluated using multi-level modeling, paired t-tests including a false discovery rate (FDR) approach, and ordinary least squares linear regression analysis of frozen versus ambient results. Using the paired t-test and confirmed by FDR testing, differences in the results for the ambient and frozen samples were found to be statistically significant at p < 0.05 for four assays (DiaSorin, DIAsource, Siemens, and SNIBE prototype). For all 14 LC-MS/MS assays, the differences in the results for the ambient- and frozen-shipped samples were not found to be significant at p < 0.05 indicating that these analytes were stable during shipment at ambient conditions. Even though assay results have been shown to vary considerably among different 25(OH)D assays in other studies, the results of this study also indicate that sample handling/transport conditions may influence 25(OH)D assay response for several assays. [less ▲]

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See detailA model of the optimal allocation of government expenditures
Pestieau, Pierre ULiege; Fan, Simon; Pang, Yu

in Journal of Public Economic Theory (in press)

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See detailFunctions of the Word 'Democracy' in the Speeches of Right-Wing Populist Parties: Critical Discourse Analysis of the Rassemblement National and the Freiheitliche Partei Österreichs
Debras, François ULiege

in Les Cahiers Protagoras (in press), 9

The literature has defined “right-wing populism” (RWP) as political organizations that oppose to democracy. Depending on the author, this opposition is institutional or value-driven. However, RWP presents ... [more ▼]

The literature has defined “right-wing populism” (RWP) as political organizations that oppose to democracy. Depending on the author, this opposition is institutional or value-driven. However, RWP presents itself as the defender of democracy. The literature argues that this is a symbolic discourse rooted in a strategy of “normalization” of the party. I aim to further revise this assumption by asking the question: in the discourse of the Rassemblent National (RN) in France and the Freiheitliche Partei Österreichs (FPÖ) in Austria, is “democracy” a “cosmetic term” or is the word “democracy” also ideologically loaded? I first propose to concentrate on the discursive relationship between RWP and the concept of democracy as studied in the literature. Second, I will present the methodology that were selected. Third, I will study the term “democracy” in RN and FPÖ speeches by carrying out a lexicometric analysis and a critical discourse analysis (CDA). I will then deal with different functions of the term “democracy” (cosmetic or symbolic, rhetorical or strategic and ideological) while highlighting tensions in the rhetoric. [less ▲]

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See detailAn individualised approach for a one-abutment one-time protocol using full guided surgery: a 4-year follow-up case series
VINCENT, Kim ULiege; LI MANNI, Lou; Mainjot, Amélie ULiege et al

in International Journal of Computerized Dentistry (in press)

Aim: The aim of this case series was to evaluate the 4-year outcomes of implants placed in the aesthetic area using static computer-assisted implant surgery (s-CAIS) and restored with a one-abutment one ... [more ▼]

Aim: The aim of this case series was to evaluate the 4-year outcomes of implants placed in the aesthetic area using static computer-assisted implant surgery (s-CAIS) and restored with a one-abutment one-time (OAOT) protocol using custom-made zirconia abutments and cemented provisional crowns manufactured prior to surgery. Material and methods: Ten consecutive implants were placed in the aesthetic area. Based on a digital implant and prosthodontic planning, surgical guides were ordered and used for the preparation of definitive custom-made zirconia abutments and polymethylmethacrylate provisional crowns. Implants were placed using the s-CAIS guide, and prosthetic components were placed immediately. Implant outcomes were evaluated at the time of surgery, after 4 months and after 4 years. Results: All implants were successfully placed with s-CAIS and restored with final abutments and provisional crowns. No major prosthetic adverse events were observed. After 4 years, the implant survival rate was 100%, minor peri-implant bleeding on probing was reported, and very stable peri-implant bone levels were observed. The pink aesthetic score showed that the prosthetic components were well integrated, and the peri-implant soft tissues were stable. Conclusions: Within the limits of this case series, these results suggest that emerging digital workflows allow the manufacture of final custom-made abutments and provisional crowns prior to surgery. This individualised OAOT procedure may reduce cement-related complications and improve aesthetic outcomes by optimising soft tissue healing with prosthetic components. However, such protocols have evolved towards full digital workflows, and comparative clinical trials are needed. [less ▲]

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See detailLa faillite des liquidations déficitaires : The Usual Suspects
Aydogdu, Roman ULiege

in Revue de Droit Commercial Belge (in press)

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See detailEffects of the class II Carriere motion® appliance on children: A randomized controlled trial
Clermont, Anaïs; Albert, Adelin ULiege; BRUWIER, Annick ULiege

in Journal of Clinical Orthodontics (in press)

Objective: To assess the skeletal, dento-alveolar and dental effects of the class II Carriere motion® on young subjects. Materials and Methods: 32 class II subjects (mean age 9.4 ± 1.6 years) were ... [more ▼]

Objective: To assess the skeletal, dento-alveolar and dental effects of the class II Carriere motion® on young subjects. Materials and Methods: 32 class II subjects (mean age 9.4 ± 1.6 years) were randomly allocated to either the Carriere motion® appliance group (n=15), or to a control group (n=17). Digital dental cast measurements and cephalometric analysis were performed before treatment (T0), at removal of the device for the appliance group, and after a period of 9 months for the control group (T1). The duration of treatment was recorded and the patient’s satisfaction with the appliance was assessed through a questionnaire. Results: The effects of the Carriere Motion leading to Class I were essentially dento-alveolar. Significant decreases of ANB and SNA angles were evidenced, as well as an increase by 1.3 degree of FMA angle compared to control subjects. Distalization and distal rotation of upper molars were observed. The mandibular teeth mesialized and the lower incisors proclined. A clockwise rotation of the occlusal plane occurred. The treatment lasted 7.6 ± 1.6 months with a mean of 6.1 ± 1.1 appointments. The patient experience with the Carriere motion® was quite positive. Conclusion: The Carriere motion® proved its efficiency in correcting class II malocclusion, essentially by dento-alveolar effects. This easy-to-use appliance is indicated in early orthodontic treatment, when the correction is urgently required (prevention of incisor trauma in case of large overjet, periodontal risk for upper incisor in case of deep bite and sleep apnea). [less ▲]

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See detailComprehensive analysis of the immunomodulatory effects of rapamycin on human T cells in graft-versus-host disease prophylaxis
Ehx, Grégory ULiege; Ritacco, Caroline ULiege; HANNON, Muriel ULiege et al

in American Journal of Transplantation (in press)

Graft-versus-host disease (GVHD) is a major cause of toxicity after allogeneic hematopoietic cell transplantation (allo-HCT). While rapamycin (RAPA) is commonly used in GVHD prophylaxis in combination ... [more ▼]

Graft-versus-host disease (GVHD) is a major cause of toxicity after allogeneic hematopoietic cell transplantation (allo-HCT). While rapamycin (RAPA) is commonly used in GVHD prophylaxis in combination with a calcineurin inhibitor (CNI), the understanding of its mechanism of action on human T cells is still incomplete. Here, we performed an extensive analysis of RAPA effects on human T cells in a humanized mouse model of GVHD, in ex-vivo T-cell cultures and in patients given RAPA plus tacrolimus as GVHD prophylaxis after non-myeloablative allo-HCT. We demonstrate that RAPA mitigates GVHD by decreasing T-cell engraftment and differentiation, inhibiting CD8+ T-cell activation and increasing the long-term IL-2 secretion, thereby supporting regulatory T-cell (Treg) proliferation. In contrast, graft-versus-leukemia effects were not abrogated, as RAPA-treated T cells had increased resistance to apoptosis and retained their effector function and proliferative capacity upon re-stimulation. Importantly, we found that RAPA impact on Treg and CD8+ T cells was closely dependent upon IL-2 signaling and that therapeutic options interfering with IL-2, such as calcineurin inhibitors, antagonize the IL-2-dependent promotion of Treg mediated by RAPA. Our results suggest that RAPA immunological efficacy could be improved in combination with drugs having possible synergistic effects such as the hypomethylating agent 5-azacytidine. [less ▲]

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See detailAge-adapted percentiles of measured glomerular filtration in healthy individuals: extrapolation to living kidney donors over 65 years.
DELANAYE, Pierre ULiege; Gaillard, François; van der Weijden, Jessica et al

in Clinical chemistry and laboratory medicine (in press)

OBJECTIVES: Most data on glomerular filtration rate (GFR) originate from subjects <65 years old, complicating decision-making in elderly living kidney donors. In this retrospective multi-center study, we ... [more ▼]

OBJECTIVES: Most data on glomerular filtration rate (GFR) originate from subjects <65 years old, complicating decision-making in elderly living kidney donors. In this retrospective multi-center study, we calculated percentiles of measured GFR (mGFR) in donors <65 years old and extrapolated these to donors ≥65 years old. METHODS: mGFR percentiles were calculated from a development cohort of French/Belgian living kidney donors <65 years (n=1,983), using quantiles modeled as cubic splines (two linear parts joining at 40 years). Percentiles were extrapolated and validated in an internal cohort of donors ≥65 years (n=147, France) and external cohort of donors and healthy subjects ≥65 years (n=329, Germany, Sweden, Norway, France, The Netherlands) by calculating percentages within the extrapolated 5th-95th percentile (P5-P95). RESULTS: Individuals in the development cohort had a higher mGFR (99.9 ± 16.4 vs. 86.4 ± 14 and 82.7 ± 15.5 mL/min/1.73 m(2)) compared to the individuals in the validation cohorts. In the internal validation cohort, none (0%) had mGFR below the extrapolated P5, 12 (8.2%) above P95 and 135 (91.8%) between P5-P95. In the external validation cohort, five subjects had mGFR below the extrapolated P5 (1.5%), 25 above P95 (7.6%) and 299 (90.9%) between P5-P95. CONCLUSIONS: We demonstrate that extrapolation of mGFR from younger donors is possible and might aid with decision-making in elderly donors. [less ▲]

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See detailLa tête végétalisée dans la mosaïque romaine. Remise en contexte et identifications
Derwael, Stéphanie ULiege

in Lettre de l'AFEMA (in press)

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See detailOccurrence of ‘gang of five’ Shiga toxin-producing Escherichia coli serogroups on Belgian dairy cattle farms by overshoe sampling
Engelen, Frederik; Thiry, Damien ULiege; Devleesschauwer, Brecht et al

in Letters in Applied Microbiology (in press), (702), 415-419

Significance and Impact of the Study: Shiga toxin-producing Escherichia coli (STEC) are important foodborne pathogens responsible for haemorrhagic colitis and haemolytic-uremic syndrome. Cattle are the ... [more ▼]

Significance and Impact of the Study: Shiga toxin-producing Escherichia coli (STEC) are important foodborne pathogens responsible for haemorrhagic colitis and haemolytic-uremic syndrome. Cattle are the major natural reservoir and excrete these bacteria in their faeces. This study investigated the occurrence and pathogenic potential of ‘gang of five’ STEC (O26, O103, O111, O145, O157) on Belgian dairy cattle farms and implemented a practical and animal-friendly sampling method aimed at promoting more widespread STEC surveillance in the bovine reservoir. Since these serogroups are most frequently implicated in human illness, more information on their presence in the bovine reservoir is required to develop efficient strategies aimed at reducing bovine carriage and the risk of human transmission. [less ▲]

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See detailEntomophagy in Gabon across the African context
Detilleux, Loïc ULiege; Poligui, René Noël; Iannello, Lisa ULiege et al

in Journal of Insects as Food and Feed (in press)

Entomophagy is well established in the food habits of Africa; however, country-wide knowledge remains limited for several countries, including Gabon. Here, two surveys on entomophagy were conducted in ... [more ▼]

Entomophagy is well established in the food habits of Africa; however, country-wide knowledge remains limited for several countries, including Gabon. Here, two surveys on entomophagy were conducted in Gabon through face-to-face interviews. The first survey collected information on insect eating habits from 169 potential consumers. Edible insects formed part of the diet of most Gabonese people, with more than 60% of consumers within participants, and were particularly common among the Teke ethnic group (93%). Familiarity with edible insects was influenced by culture and family, but not by gender or study level. The second survey focused on edible insect species and their host plants, by interviewing a sample of 113 both villagers and retailers. Seventy-five species of insects from six insect orders (Coleoptera, Hemiptera, Isoptera, Lepidoptera, Odonata and Orthoptera) were consumed in Gabon, and were collected from 48 species of host plant. Many insects were formerly reported in the literature related to entomophagy; however, 13 species were newly reported as edible in this study: Bidessus batekensis, Bunaeopsis licharbas, Copelatus ateles, Copelatus confinis, Copelatus fizpaci, Copelatus tondangoyei, Gonobombyx angulata, Gonometa titan, Hydrocyrius columbiae, Oxychirus semisericeus, Philobota sp., Psara sp. and Ptyelus flavescens. Consequently, these surveys highlighted that entomophagy is common in Gabon. However, strategies to promote edible insects are needed to have a significant impact on food issues in Gabon (e.g. food insecurity and dependence on foreign food supplies). Additional researches on entomophagy in Gabon are required to further develop these strategies. [less ▲]

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See detailTerritoire de mobilité et territoire social Structuration du territoire d’approvisionnement en matières premières lithiques dans l’Épigravettien récent au nord-ouest de l’Italie
Tomasso, Antonin ULiege

in Bulletin de la Société Préhistorique Française (in press), 115

Dans le contexte du Paléolithique supérieur, la techno-économie des industries lithiques s’est concentrée sur l’étude des systèmes de mobilité. Les dimensions sociales et économiques des systèmes de ... [more ▼]

Dans le contexte du Paléolithique supérieur, la techno-économie des industries lithiques s’est concentrée sur l’étude des systèmes de mobilité. Les dimensions sociales et économiques des systèmes de production lithiques n’ont jusqu’ici été considérées qu’à la marge, ceci en raison d’une difficulté à discriminer les différentes modalités d’acquisition et de circulation des matériaux dans l’espace. À partir de données issues de sites de l’Épigravettien récent de Provence, de Ligurie, de Toscane et des Marches et en fondant nos analyses sur un solide référentiel pétroarchéologique, nous esquissons la trame d’un modèle de structuration territoriale, pouvant être décrit par au moins deux niveaux distincts. Le niveau inférieur correspond à des circulations de matériaux intenses, multidirectionnelles et multipolaires, sur des distances pouvant atteindre 300 km. Il définit deux unités : l’arc liguro-provençal et la Toscane. Le niveau supérieur est défini par une circulation unidirectionnelle depuis l’Italie centrale vers les deux unités précitées. À partir d’une analyse techno-économique des assemblages nous proposons d’interpréter le premier niveau d’organisation comme la matérialisation de territoires étendus (espaces de mobilité) et le second comme la trace d’une fraction d’un territoire social à plus large échelle. La mise en regard de ce territoire – ou réseau – social et de l’espace épigravettien italique conduit à s’interroger sur les relations entre réseaux de transferts matériels et diffusions de normes et traditions techniques aboutissant à la définition des entités chronoculturelles en préhistoire [less ▲]

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See detailPreferences of Small-Scale Farmers for Innovative Farming Techniques in Volcanic Highlands in Rwanda
Maniriho, Aristide ULiege; Musabanganji, Edouard; Mulumeoderhwa Munyakazi, Fidèle ULiege et al

in Agris On-line Papers in Economics and Informatics (in press), XIV(22),

This paper attempted to identify the determinant factors of innovative technologies preferences by small-scale farmers in the Volcanic Highlands in Rwanda. Data used were collected from a random sample of ... [more ▼]

This paper attempted to identify the determinant factors of innovative technologies preferences by small-scale farmers in the Volcanic Highlands in Rwanda. Data used were collected from a random sample of 401 small-scale crop producers using a structured questionnaire in the study area. A logit regression model was specified, whereby a binary maximum likelihood estimation method was used to identify the factors affecting of the adoption of chemical fertilizers, the determinants of the combined use of chemical and organic fertilizers, the determinants of the adoption of improved seeds, as well as the determinant factors of appropriate use of pesticides. The results showed that farmer’s education level, farming experience, membership to farm cooperative, the number of extension visits, and crop farming are the factors that affect positively the probability of adopting one or other of the four innovative farming techniques. From these results, we suggest the enhancement of extension services and other needed support to small-scale farmers (grants and subsidies, access to finance for example), the spread of professional trainings to farmers, and the increased farmers’ access to high-yielding seed varieties if farming professionalization and innovative farming techniques are still among the development goals. [less ▲]

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See detailFigures multimodales
Seron, Denis ULiege

in Bulletin d'Analyse Phénoménologique (in press)

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See detailThe influence of interorganizational collaboration on logic conciliation and tensions within hybrid organizations: insights from social enterprise-corporate collaborations
Savarese, Claudia ULiege; Huybrechts, Benjamin ULiege; Hudon, Marek

in Journal of Business Ethics (in press)

An increasing amount of research has examined the management of competing logics, and possible tensions arising between them, within “hybrid organizations”. However, the ways in which the relationships of ... [more ▼]

An increasing amount of research has examined the management of competing logics, and possible tensions arising between them, within “hybrid organizations”. However, the ways in which the relationships of hybrids with other organizations shape the conciliation of these logics and tensions has received limited attention so far. In this theoretical paper, we examine how hybrid organizations deal with interorganizational collaboration, in particular whether and how their hybridity can be maintained when they partner with “dominant-logic organizations”. Drawing on empirical literature on social enterprise-corporate collaborations, we develop a framework and several propositions on how competing logics and their balancing within hybrid organizations may be affected by interactions with organizations underpinned by one dominant logic. We suggest that influences will mostly depend on the type of collaboration pursued. A collaboration based on a lower level of engagement and interaction between the two partners is likely to give precedence to one logic over the other, reducing inter-logic tensions but possibly compromising organizational hybridity. By contrast, a collaboration featuring numerous interactions and mission compatibility may facilitate sustained hybridity if tensions are acknowledged and managed. Our propositions contribute to the literatures on hybrid organizations, interorganizational collaboration, and social enterprise. [less ▲]

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See detailVitamin D Standardization Program (VDSP) Intralaboratory Study for the Assessment of 25-Hydroxyvitamin D Assay Variability and Bias.
Wise, Stephen A.; Camara, Johanna E.; Sempos, Christopher T. et al

in The Journal of steroid biochemistry and molecular biology (in press)

An intralaboratory study assessing assay variability and bias for determination of serum total 25-hydroxyvitamin D [25(OH)D] was conducted by the Vitamin D Standardization Program (VDSP). Thirteen assays ... [more ▼]

An intralaboratory study assessing assay variability and bias for determination of serum total 25-hydroxyvitamin D [25(OH)D] was conducted by the Vitamin D Standardization Program (VDSP). Thirteen assays for serum total 25(OH)D were evaluated in a single laboratory including 11 unique immunoassays and one liquid chromatography - tandem mass spectrometry (LC-MS/MS) assay. Fifty single-donor serum samples, including eight samples with high concentrations of 25(OH)D(2) (> 30 nmol/L), were assigned target values for 25(OH)D(2) and 25(OH)D(3) using reference measurement procedures (RMP). Using four replicate measurements for each sample, the mean total percent coefficient of variation (%CV) and mean % bias from the target values were determined for each assay using the 50 single-donor samples and a 42-sample subset, which excluded 8 high 25(OH)D(2) concentration samples, and compared with VDSP performance criteria of ≤ 10% CV and ≤ ±5% mean bias. All 12 assays achieved the performance criterion for %CV, and 9 of the 12 assays were within ≤ ±5 % mean bias. The Fujirebio Inc. assay exhibited the lowest %CV and highest percentage of individual measurements within ≤ ±5% mean bias. Ten immunoassays exhibited changes in response due to the high 25(OH)D(2) samples with Abbott, Biomérieux, DiaSorin, DIAsource, and IDS-iSYS assays having the largest deviations. The Fujirebio Inc. and Beckman Coulter assays were only minimally affected by the presence of the high 25(OH)D(2) samples. Samples with high concentrations of 25(OH)D(2) provided a critical performance test for immunoassays indicating that some assays may not have equal response or recovery for 25(OH)D(2) and 25(OH)D(3). [less ▲]

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See detailDevelopment of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3- hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors
Etse, Koffi Senam ULiege; Dorosz, Jerzy; Mc Lain Christensen et al

in ACS Chemical Neurosciences (in press)

Based on the activity of 1,2,4-benzothiadiazine 1,1-dioxides as AMPAR-PAMs, thiochroman 1,1-dioxides were designed apply- ing the isosteric replacement concept. The new compounds expressed a strong ... [more ▼]

Based on the activity of 1,2,4-benzothiadiazine 1,1-dioxides as AMPAR-PAMs, thiochroman 1,1-dioxides were designed apply- ing the isosteric replacement concept. The new compounds expressed a strong modulatory activity on AMPARs in vitro, although lower than their corresponding benzothiadiazine analogues. The pharmacokinetic profile of three thiochroman 1,1-dioxides (12a, 12b, 12e) was exam- ined in vivo after oral administration, showing that these compounds freely cross the blood-brain barrier. Structural analysis was achieved using X-ray crystallography after cocrystallisation of the racemic compound 12b in complex with GluA2-LBD (L504Y/N775S). Interestingly, both enantiomers of 12b were found to interact with the GluA2-LBD dimer interface, almost identically to its benzothiadiazine analogue, BPAM344 (4). The interactions of the two enantiomers in the cocrystal were further analyzed (mapping Hirshfeld surfaces and 2D finger- print) and compared to those of 4. Taken together, these data explain the lower affinity on AMPARs of thiochroman 1,1-dioxides compared to their corresponding 1,2,4-benzothiadiazine 1,1-dioxides. [less ▲]

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See detailCan video-assistance improve the quality of pediatric dispatcher-assisted cardiopulmonary resuscitation? (IN PROGRESS)
PETERS, Michaël ULiege; Stipulante, Samuel ULiege; Cloes, Véronique et al

in Pediatric Emergency Care (in press)

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See detailProspective association between diabetes diagnosis, HbA1c, glycaemia and frailty trajectories in an elderly population
Aguayo Diaz, Gloria ULiege; Hulman, Adam; Vaillant, Michel et al

in Diabetes Care (in press)

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See detailA new approach to constrain the seismic origin for prehistoric turbidites as applied to the Dead Sea Basin
Lu, Yin; Moernaut, Jasper; Bookman, Revital et al

in Geophysical Research Letters (in press)

The seismic origin of turbidites is verified either by correlating such layers to historic earthquakes, or by demonstrating their synchronous deposition in widely spaced, isolated depocenters. The ... [more ▼]

The seismic origin of turbidites is verified either by correlating such layers to historic earthquakes, or by demonstrating their synchronous deposition in widely spaced, isolated depocenters. The historic correlation could thus constrain the seismic intensity required for triggering turbidites. However, the historic calibration is not applicable to prehistoric turbidites. In addition, the synchronous deposition of turbidites is difficult to prove if only one deep core is drilled in a depocenter. Here, we propose a new approach that involves analyzing the underlying in situ deformations of prehistoric turbidites recorded in a 457 m-long core from the Dead Sea center, in order to establish their seismic origin. These in situ deformations have been verified as seismites and could thus authenticate the trigger for each overlying turbidite. Moreover, our high-resolution chemical and sedimentological data validate the previous hypothesis that Dead Sea soft-sediment deformations formed at the sediment-water interface. [less ▲]

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See detailImpact of Different Kinds of Child Abuse on Sense of Parental Competence in Parents Who Were Abused in Childhood
Baiverlin, Audrey ULiege; Gallo, Alicia ULiege; Blavier, Adelaïde ULiege

in European Journal of Trauma and Dissociation (in press)

The purpose of this article is to study sense of parental competence in parents who experienced abuse in childhood. Many studies have shown that the kind of abuse (physical, emotional, sexual, neglect ... [more ▼]

The purpose of this article is to study sense of parental competence in parents who experienced abuse in childhood. Many studies have shown that the kind of abuse (physical, emotional, sexual, neglect) that the parent experienced in childhood and the co-occurrence of several types of abuse affect the sense of parental competence. In particular, we focused on the difference between sexual abuse and other kinds of abuse. The instruments used to collect data were the French versions of the Childhood Trauma Questionnaire, which assesses abuse, and the Parenting Sense of Competence Scale, which assesses efficacy and satisfaction. These questionnaires were designed to quantitatively evaluate the kind of abuse experienced during childhood and the sense of parental competence. We collected 828 valid protocols. The statistical analyses show that sense of parental competence is lower in parents who were abused during their childhood than in those who were not. More specifically, our results show that these parents feel less satisfaction, one of the two components of the sense of parental competence. [less ▲]

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See detailA Comparative Study between Major Crop (Potato) and Minor Crop (Onion) in Volcanic Highlands of Rwanda
Maniriho, Aristide ULiege; Musabanganji, Edouard; Lebailly, Philippe ULiege

in Journal of Agriculture and Crops (in press)

This paper aims to assess the competition between the priority (major) crops and the non priority (minor) crops. Competition between crops is defined as the significant major differences between two crops ... [more ▼]

This paper aims to assess the competition between the priority (major) crops and the non priority (minor) crops. Competition between crops is defined as the significant major differences between two crops in terms of production costs and their performance. Data were collected using a questionnaire administered to a random sample of 226 small scale crop producers including 94 onion producers and 132 potato producers. The T-test was conducted to state whether there is significant difference of mean land sizes, mean crop yields, mean selling prices, and mean net farm incomes between the two groups of crop producers. Results showed non significant difference between the mean land size allocated to onion production and that allocated to potato farming. Results also indicate that onion yield is significantly greater than potato yield, onion selling price is significantly greater than that of potato, and the net income from onion production is far away greater than the income from potato production. It is remarkable that, in some circumstances, the authorities may prioritize and thus propose to farmers the crops that are less competitive considering their price, yield or income, if the current climatic conditions and economic settings are maintained in the medium or long term. Referring to these findings, policy efforts should encourages to the farmers to shift from potato farming to onion production, or simply inclusion of crop diversification via adopting onion may be the best option to maximize the potentials of the selected crops. [less ▲]

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See detailRisk factors for a severe form of COVID-19 after allogeneic haematopoietic stem cell transplantation : a SFGM-TC multicentre cohort study
Xhaard, A.; Xhaard, C.; d'Aveni, M. et al

in British Journal of Haematology (in press)

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See detailAssessment of serum total 25-hydroxyvitamin D assay commutability of Standard Reference Materials and College of American Pathologists Accuracy-Based Vitamin D (ABVD) Scheme and Vitamin D External Quality Assessment Scheme (DEQAS) materials: Vitamin D Standardization Program (VDSP) Commutability Study 2.
Camara, Johanna E.; Wise, Stephen A.; Hoofnagle, Andrew N. et al

in Analytical and bioanalytical chemistry (in press)

An interlaboratory study was conducted through the Vitamin D Standardization Program (VDSP) to assess commutability of Standard Reference Materials® (SRMs) and proficiency testing/external quality ... [more ▼]

An interlaboratory study was conducted through the Vitamin D Standardization Program (VDSP) to assess commutability of Standard Reference Materials® (SRMs) and proficiency testing/external quality assessment (PT/EQA) samples for determination of serum total 25-hydroxyvitamin D [25(OH)D] using ligand binding assays and liquid chromatography-tandem mass spectrometry (LC-MS/MS). A set of 50 single-donor serum samples were assigned target values for 25-hydroxyvitamin D(2) [25(OH)D(2)] and 25-hydroxyvitamin D(3) [25(OH)D(3)] using reference measurement procedures (RMPs). SRM and PT/EQA samples evaluated included SRM 972a (four levels), SRM 2973, six College of American Pathologists (CAP) Accuracy-Based Vitamin D (ABVD) samples, and nine Vitamin D External Quality Assessment Scheme (DEQAS) samples. Results were received from 28 different laboratories using 20 ligand binding assays and 14 LC-MS/MS methods. Using the test assay results for total serum 25(OH)D (i.e., the sum of 25(OH)D(2) and 25(OH)D(3)) determined for the single-donor samples and the RMP target values, the linear regression and 95% prediction intervals (PIs) were calculated. Using a subset of 42 samples that had concentrations of 25(OH)D(2) below 30 nmol/L, one or more of the SRM and PT/EQA samples with high concentrations of 25(OH)D(2) were deemed non-commutable using 5 of 11 unique ligand binding assays. SRM 972a (level 4), which has high exogenous concentration of 3-epi-25(OH)D(3), was deemed non-commutable for 50% of the LC-MS/MS assays. [less ▲]

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See detailExtremal connectedness of hedge funds
Mhalla, Linda; Hambuckers, Julien ULiege; Lambert, Marie ULiege

in Journal of Applied Econometrics (in press)

We propose a dynamic measure of extremal connectedness tailored to the short reporting period and unbalanced nature of hedge funds data. Using multivariate extreme value regression techniques, we estimate ... [more ▼]

We propose a dynamic measure of extremal connectedness tailored to the short reporting period and unbalanced nature of hedge funds data. Using multivariate extreme value regression techniques, we estimate this measure conditional on factors reflecting the economic uncertainty and the state of the financial markets, and derive risk indicators reflecting the likelihood of extreme spillovers. Empirically, we study the dynamics of tail dependencies between hedge funds grouped per investment strategies, as well as with the banking sector. We show that during crisis periods, some pairs of strategies display an increase in their extremal connectedness, revealing a higher likelihood of simultaneous extreme losses. We also find a sizable tail dependence between hedge funds and banks, indicating that banks are more likely to suffer extreme losses when the hedge fund sector does. Our results highlight that a proactive regulatory framework should account for the dynamic nature of the tail dependence and its link with financial stress. [less ▲]

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See detailRelational (im)mobilities: A case study of Senegalese coastal fishing populations
Zickgraf, Caroline ULiege

in Journal of Ethnic and Migration Studies (in press)

Immobility and mobility are often viewed as fixed, binary opposites: one is either a migrant or a non-migrant. Yet, everyday experiences and realities elude such simple bifurcation. Non-migrants are not ... [more ▼]

Immobility and mobility are often viewed as fixed, binary opposites: one is either a migrant or a non-migrant. Yet, everyday experiences and realities elude such simple bifurcation. Non-migrants are not necessarily immobile: they frequently participate in small-scale movements and are well-engaged in social spaces that cross international borders. Similarly, migrants often engage in corporeal, material and communicative practices that anchor them to their homelands. This article applies a climate mobilities lens to a qualitative case study of an urban Senegalese fishing community, characterised by its ‘micro-mobilities’ as much as its international migration. Specifically, I take the case of Guet Ndar, Saint-Louis. Faced with rising seas, eroding coastlines, and depleting fish stocks and biodiversity, Guet Ndarians abroad and at home respond to the ensuing degradation of livelihoods and the destruction of homes by altering their mobility patterns through circular labour mobility to Mauritania, which then enables smaller-scale local movements including self-relocation via social and financial remittances. I argue that (im)mobilities are neither fixed nor all-encompassing but are rather relational and uneven – in time, space, and agency – and that environmental changes pressure people, regardless of their migration status, to redirect their (im)mobilities into new constellations. [less ▲]

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See detailPractical Considerations for the Clinical Application of Bone Turnover Markers in Osteoporosis.
Vasikaran, Samuel D.; Miura, Masakazu; Pikner, Richard et al

in Calcified Tissue International (in press)

Bone turnover markers (BTMs) are released during the bone remodelling cycle and are measurable in blood or urine, reflecting bone remodelling rate. They have been useful in elucidating the ... [more ▼]

Bone turnover markers (BTMs) are released during the bone remodelling cycle and are measurable in blood or urine, reflecting bone remodelling rate. They have been useful in elucidating the pharmacodynamics and effectiveness of osteoporosis medication in clinical trials and are increasingly used in routine clinical management of osteoporosis, especially for monitoring therapy, in addition to their use in other metabolic bone disease such as Paget's disease of bone and osteomalacia. Serum β isomerised C-terminal telopeptide of type I collagen and pro-collagen I N-terminal propeptide have been designated as reference BTMs for use in osteoporosis. In addition, bone-specific isoenzyme of alkaline phosphatase (B-ALP) secreted by osteoblasts and tartrate-resistant acid phosphatase 5b (TRACP-5b) secreted by osteoclasts are also found to be specific markers of bone formation and resorption, respectively. The concentrations of the latter enzymes in blood measured by immunoassay provide reliable measures of bone turnover even in the presence of renal failure. B-ALP is recommended for use in the assessment of renal bone disease of chronic kidney disease, and TRACP-5b shows promise as a marker of bone resorption in that condition. BTMs in blood do not suffer from biological variation to the same extent as the older BTMs that were measured in urine. Appropriate patient preparation and sample handling are important in obtaining accurate measures of BTMs for clinical use. Reference change values and treatment targets have been determined for the reference BTMs for their use in monitoring osteoporosis treatment. Further ongoing studies will enhance their clinical applications. [less ▲]

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See detailProduct Digitalization at Nike: The Future is Now
Standaert, Willem ULiege

in Journal of Information Technology Teaching Cases (in press)

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See detailHippocampus co-atrophy pattern in dementia deviates from covariance patterns across the lifespan.
Plachti, Anna; Kharabian, Shahrzad; Eickhoff, Simon B. et al

in Brain : a journal of neurology (in press)

The hippocampus is a plastic region and highly susceptible to ageing and dementia. Previous studies explicitly imposed a priori models of hippocampus when investigating ageing and dementia-specific ... [more ▼]

The hippocampus is a plastic region and highly susceptible to ageing and dementia. Previous studies explicitly imposed a priori models of hippocampus when investigating ageing and dementia-specific atrophy but led to inconsistent results. Consequently, the basic question of whether macrostructural changes follow a cytoarchitectonic or functional organization across the adult lifespan and in age-related neurodegenerative disease remained open. The aim of this cross-sectional study was to identify the spatial pattern of hippocampus differentiation based on structural covariance with a data-driven approach across structural MRI data of large cohorts (n = 2594). We examined the pattern of structural covariance of hippocampus voxels in young, middle-aged, elderly, mild cognitive impairment and dementia disease samples by applying a clustering algorithm revealing differentiation in structural covariance within the hippocampus. In all the healthy and in the mild cognitive impaired participants, the hippocampus was robustly divided into anterior, lateral and medial subregions reminiscent of cytoarchitectonic division. In contrast, in dementia patients, the pattern of subdivision was closer to known functional differentiation into an anterior, body and tail subregions. These results not only contribute to a better understanding of co-plasticity and co-atrophy in the hippocampus across the lifespan and in dementia, but also provide robust data-driven spatial representations (i.e. maps) for structural studies. [less ▲]

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See detailNeuroimaging and neurophysiological diagnosis and prognosis in paediatric disorders of consciousness
Vitello, Marie ULiege; Szymkowicz, Emilie ULiege; Laureys, Steven ULiege et al

in Developmental Medicine and Child Neurology (in press)

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See detailDiagnostic Accuracy of Noninvasive Bone Turnover Markers in Renal Osteodystrophy.
Jørgensen, Hanne Skou; Behets, Geert; Viaene, Liesbeth et al

in American journal of kidney diseases : the official journal of the National Kidney Foundation (in press)

RATIONALE & OBJECTIVE: Bone biopsy remains the gold standard for diagnosing renal osteodystrophy as comparable non-invasive alternatives have yet to be established. The aim of this study was to ... [more ▼]

RATIONALE & OBJECTIVE: Bone biopsy remains the gold standard for diagnosing renal osteodystrophy as comparable non-invasive alternatives have yet to be established. The aim of this study was to investigate the diagnostic accuracy of biochemical markers of skeletal remodeling to predict bone turnover. STUDY DESIGN: Cross-sectional retrospective diagnostic test study. SETTING & PARTICIPANTS: Patients with chronic kidney disease stages G4-G5D and kidney transplant recipients with successful transiliac bone biopsies. TESTS COMPARED: Bone turnover as determined by bone histomorphometry was compared to the following biochemical markers: Full-length (1-84) parathyroid hormone (PTH), bone-specific alkaline phosphatase (BsAP), intact procollagen type I N-terminal propeptide (PINP), and tartrate-resistant acid phosphatase isoform 5b (TRAP5b). OUTCOME: Diagnostic performance was evaluated by area under the receiver operator characteristics curve (AUC), sensitivity, specificity, and negative and positive predictive values. Optimal diagnostic cutoffs were determined in an exploration cohort (n=100) and validated in a separate cohort (n=99). RESULTS: All biomarkers differed across categories of low 33 (17%), normal 109 (55%), and high 57 (29%) bone turnover. AUC values were in the range of 0.75 - 0.85. High negative predictive values (≥90%) were found for both high and low bone turnover, indicating the ability to rule out both conditions using the suggested biomarker cutoffs. The highest diagnostic performances were seen with combinations of biomarkers, with overall diagnostic accuracies of 90% for high turnover, and 78% for low turnover. Results were comparable for kidney transplant candidates and recipients in a sensitivity analysis. LIMITATIONS: The single-center approach and heterogeneity of the study cohort are main limitations of this study. CONCLUSIONS: We conclude that the diagnostic performance of biochemical markers of bone turnover is acceptable, with clinical utility in ruling out both high and low turnover bone disease. [less ▲]

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See detailNeural bases of inhibitory control: Combining transcranial magnetic stimulation and magnetic resonance imaging in alcohol-use disorder patients.
Quoilin, Caroline; Dricot, Laurence; Genon, Sarah ULiege et al

in NeuroImage (in press)

Inhibitory control underlies the ability to inhibit inappropriate responses and involves processes that suppress motor excitability. Such motor modulatory effect has been largely described during action ... [more ▼]

Inhibitory control underlies the ability to inhibit inappropriate responses and involves processes that suppress motor excitability. Such motor modulatory effect has been largely described during action preparation but very little is known about the neural circuit responsible for its implementation. Here, we addressed this point by studying the degree to which the extent of preparatory suppression relates to brain morphometry. We investigated this relationship in patients suffering from severe alcohol use disorder (AUD) because this population displays an inconsistent level of preparatory suppression and major structural brain damage, making it a suitable sample to measure such link. To do so, 45 detoxified patients underwent a structural magnetic resonance imaging (MRI) and performed a transcranial magnetic stimulation (TMS) experiment, in which the degree of preparatory suppression was quantified. Besides, behavioral inhibition and trait impulsivity were evaluated in all participants. Overall, whole-brain analyses revealed that a weaker preparatory suppression was associated with a decrease in cortical thickness of a medial prefrontal cluster, encompassing parts of the anterior cingulate cortex and superior-frontal gyrus. In addition, a negative association was observed between the thickness of the supplementary area (SMA)/pre-SMA and behavioral inhibition abilities. Finally, we did not find any significant correlation between preparatory suppression, behavioral inhibition and trait impulsivity, indicating that they represent different facets of inhibitory control. Altogether, the current study provides important insight on the neural regions underlying preparatory suppression and allows highlighting that the excitability of the motor system represents a valuable read-out of upstream cognitive processes. [less ▲]

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See detailParadoxical Tensions Related to AI-Powered Evaluation Systems in Competitive Sports
Mazurova, Elena; Standaert, Willem ULiege; Penttinen, Esko et al

in Information Systems Frontiers (in press)

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See detailCompte-rendu de J. Gayon, L’Identité. Dictionnaire encyclopédique
Recchia, Fabio ULiege

in Revue Philosophique de Louvain (in press), 4/2020-2021

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See detailCovid-19: contribution of clinical characteristics and laboratory features for early detection of patients with high risk of severe evolution
Sepulchre, Edith; Pittie, Guillaume; Stojkovic, Violeta et al

in Acta Clinica Belgica (in press)

The aim of this study was to identify early clinical and laboratory predictive factors of a severe coronavirus disease 2019 (COVID-19). The study revealed clinical and laboratory features able to predict ... [more ▼]

The aim of this study was to identify early clinical and laboratory predictive factors of a severe coronavirus disease 2019 (COVID-19). The study revealed clinical and laboratory features able to predict high risk of ICU requirement, or even death, at admission time. These results provide a potential tool for patient’s triage in a context of pandemic. [less ▲]

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See detailPotential for the valorization of brewer’s spent grains: a case study for the sequential extraction of saccharides and lignin
De Crane d'Heysselaer, Simon ULiege; Bockstal, Lauris ULiege; Jacquet, Nicolas ULiege et al

in Waste Management and Research: the Journal of the International Solid Wastes and Public Cleansing Association (in press)

This study highlights the possibility of using brewers' grains (BSGs) for the successive extraction of the main lignocellulosic biopolymers, namely cellulose, hemicelluloses and lignin. An exhaustive ... [more ▼]

This study highlights the possibility of using brewers' grains (BSGs) for the successive extraction of the main lignocellulosic biopolymers, namely cellulose, hemicelluloses and lignin. An exhaustive chemical characterization revealed a variability of composition in distinct batches of BSGs, depending on their origin and the brewing process used. In particular, the protein content can vary from 13 to 23 wt.%, which is accompanied by a change in the hemicelluloses content from 9 to 23% (in the samples of our study). By applying a two-step aqueous treatment, involving an acid (1.25% v/v aq. H2SO4) and a base (3% w/v aq. NaOH) at a temperature of 120°C and fixed reaction time of a few tens of minutes (15 to 90 min), more than 80% of hemicelluloses could be recovered. Cellulose could be isolated at more than 68%, while a high purity lignin could be recovered from a lignin-rich fraction (70wt.%). Our work also suggests that the variability of the chemical composition of these brewers' grains is a hindrance to achieving process standardization and large-scale exploitation. The pooling of various materials is therefore not a recommended option, and the preliminary chemical analysis of the composition is therefore a prerequisite for an efficient extraction process. [less ▲]

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See detailFramework for Open Insurance Strategy: Insights from a European Study
Standaert, Willem ULiege; Muylle, Steve

in Geneva Papers on Risk and Insurance: Issues and Practice (in press)

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See detailAntimicrobial resistance and virulence characteristics in 3 collections of staphylococci from bovine milk samples
Fergestad, M. E.; De Visscher, S.; L’Abee-Lund, T. et al

in International Journal of Dairy Science (in press), 104(8),

Mastitis is a prevalent disease in dairy cattle, and staphylococci are among the most common causative pathogens. Staphylococci can express resistance to a range of antimicrobials, of which methicillin ... [more ▼]

Mastitis is a prevalent disease in dairy cattle, and staphylococci are among the most common causative pathogens. Staphylococci can express resistance to a range of antimicrobials, of which methicillin resistance is of particular public health concern. Additionally, Staphylococcus aureus carries a variety of virulence factors, although less is understood about the virulence of non-aureus staphylococci (NAS). The aim of our study was to identify and characterize 3 collections of staphylococcal isolates from bovine milk samples regarding antimicrobial resistance, with emphasis on methicillin resistance, and their carriage of virulence genes typically displayed by Staph. aureus. A total of 272 staphylococcal isolates collected in Norway and Belgium in 2016 were included, distributed as follows: group 1, Norway, 100 isolates; group 2, Flanders, Belgium, 64 isolates; group 3, Wallonia, Belgium, 108 isolates. Species identification was performed by use of MALDI-TOF mass spectrometry. Phenotypic resistance was determined via disk diffusion, and PCR was used for detection of methicillin resistance genes, mecA and mecC, and virulence genes. Antimicrobial resistance was common in Staphylococcus epidermidis and Staphylococcus haemolyticus from all different groups, with resistance to trimethoprim-sulfonamide frequently occurring in Staph. epidermidis and Staph. haemolyticus as well as in Staph. aureus. Resistance to penicillin was most frequently observed in group 1. Ten Belgian isolates (1 from group 2, 9 from group 3) carried the methicillin resistance determinant mecA: 5 Staph. aureus from 2 different farms and 5 NAS from 3 different farms. Almost all Staph. aureus isolates were positive for at least 3 of the screened virulence genes, whereas, in total, only 8 NAS isolates harbored any of the same genes. Our study contributes to the continuous need for knowledge regarding staphylococci from food-producing animals as a basis for better understanding of occurrence of resistance and virulence traits in these bacteria. Key words: Staphylococcus aureus, non-aureus staphylococci, antimicrobial resistance, virulence genes, bovine mastitis [less ▲]

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See detailJean A. Straus (21 avril 1945 - 5 novembre 2020)
Carlig, Nathan ULiege; Ricciardetto, Antonio ULiege

in Revue Internationale des Droits de l'Antiquité (in press)

Portrait et bibliographie de Jean A. Straus (1945-2020), papyrologue et historien de l'esclavage dans le monde gréco-romain, maître de conférence et titulaire du cours d'"Initiation à la papyrologie ... [more ▼]

Portrait et bibliographie de Jean A. Straus (1945-2020), papyrologue et historien de l'esclavage dans le monde gréco-romain, maître de conférence et titulaire du cours d'"Initiation à la papyrologie documentaire" à l'Université de Liège. [less ▲]

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See detailFigures et formes de l'indétermination. De Vase de Noces à Long Live the New Flesh
Jousten, Lison ULiege

in Dalhousie French Studies (in press), 120

Since its release in 1974, Thierry Zéno's Vase de Noces has been at the centre of various controversies that reveal its marginal character. Going far beyond the simple surrealist zoophile love story to ... [more ▼]

Since its release in 1974, Thierry Zéno's Vase de Noces has been at the centre of various controversies that reveal its marginal character. Going far beyond the simple surrealist zoophile love story to which it has sometimes been reduced, the film focuses, more fundamentally, on undermining a series of pairings (e.g., high/low, pure/impure, humanity/animality), on requalifying borders and on making light of categories. After introducing Vase de Noces as a film of indeterminacy, this article will approach the feature film from the detail by first formulating some proposals relating to the motif of nausea, which itself brings into play a series of structuring oppositions and surfaces an exorbitant principle of oscillation. This introductory step sets the stage for a conceptual and analytical shift by opening the reflection to Long Live the New Flesh (Nicolas Provost, 2009), where the question of the abject plays out on another level. By making the blind spot of the analysis a point of continuity between these two absolutely different Belgian films, the article considers the complementarity of these two objects to think of a fundamental indeterminacy specific to abjection, as it was approached by Julia Kristeva in The Powers of Horror. Abjection Essay (1980). [less ▲]

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See detailPsychopathologie et monde social : les limites de l'empathie et de la sympathie
Englebert, Jérôme ULiege

in Philosophie (in press)

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See detailThe Contemporary Legacy of Goethean Morphology : From Anschauende Urteilskraft to Algorithmic Pattern Recognition, Generation and Exploration
Petteni, Oriane ULiege

in Goethe Yearbook (in press), 29

The paper aims to produce the first-ever approach of the Goethean Morphology (GM) that reads it as the forerunner of contemporary techniques of pattern recognition, generation and exploration via natural ... [more ▼]

The paper aims to produce the first-ever approach of the Goethean Morphology (GM) that reads it as the forerunner of contemporary techniques of pattern recognition, generation and exploration via natural computing and computer graphics, based on the analysis of the specific visualization techniques that ground Goethe’s morphological method. I propose to read GM as an original practice of reduction, departing from the phenomenological realm to intuit nature’s self-generating processes. In this context, the main remit of reduction is not to simplify complexity, as is usually the case in modern natural sciences, but rather to let visually emerge the autonomous processes that superintend the generation of complexity itself. In this sense, I understand Goethe’s main gesture as an attempt to comprehend the logic of nature from within, instead of merely trying to represent or mimic it. My project intend to explore the visual devices that ground the construction of Goethe’s Urtype, the key-feature to its morphological method. I understand the Urtype as a matrix capable of generating the structures of actual and virtual entities [less ▲]

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See detailEffects of various pre-analytical conditions on blood-based biomarkers of Alzheimer's disease.
LADANG, Aurélie ULiege; Rigaud, Lucas ULiege; Sqalli, Ghali ULiege et al

in Clinical chemistry and laboratory medicine (in press)

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See detailThe Victim-Offender Overlap: The Sex Worker's Case [Submit]
André, Sophie ULiege

in European Journal of Criminology (in press)

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See detailJean A. Straus (21 avril 1945 - 5 novembre 2020)
Carlig, Nathan ULiege; Ricciardetto, Antonio ULiege

in Annales du Cercle Hutois des Sciences et Beaux-Arts (in press)

Profil biographique de Jean A. Straus (1945-2021), papyrologue spécialiste de l'esclavage antique, maître de conférences à l'Université de Liège, ancien Président du Cercle Hutois des Sciences et Beaux ... [more ▼]

Profil biographique de Jean A. Straus (1945-2021), papyrologue spécialiste de l'esclavage antique, maître de conférences à l'Université de Liège, ancien Président du Cercle Hutois des Sciences et Beaux-Arts (CHSBA). Le portrait insiste en particulier sur son rôle au sein du CHSBA et sur ses travaux en histoire locale et est suivi d'une bibliographie de ses publications dans ce domaine. [less ▲]

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See detailIn Practice, the Exploration of Design Processes : a conversation
Vandenbulcke, Benoît ULiege; Fallon, Harold; Burquel, Benoit et al

in interfere (in press)

On the occasion of the book festival 9000 boeken and of the DAM architecture book award obtained by Raamwerk In Practice: Lichtervelde Youth House, the publisher MER B&L invited the editors to organize a ... [more ▼]

On the occasion of the book festival 9000 boeken and of the DAM architecture book award obtained by Raamwerk In Practice: Lichtervelde Youth House, the publisher MER B&L invited the editors to organize a talk to discuss the books on November 6th 2021 at the Kunsthal in Ghent. We invited Aslı Çiçek, a practicing architect and visiting professor at UHasselt and UGent. She is also a member of the editorial board of OASE Journal for Architecture. We invited Freek Dendooven and Gijs De Cock as well, architects and partners of the Raamwerk firm. During the talk, Harold Fallon represented the editorial board, including Benoît Burquel and Benoît Vandenbulcke. The talk combined the perspectives of the architecture practice, of the edition and of the theory. The discussion addressed several aspects, amongst which the role of design processes in the forming of architecture theory, the authorship in multidisciplinary contexts, the relationships between text and images, the collaboration with a photographer, the issue of distance between practice and research and the significance of the small scale and detail in contemporary architecture discourse. [less ▲]

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See detailImpact of prior JAK-inhibitor therapy with ruxolitinib on outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosis: a study of the CMWP of EBMT.
Kröger, Nicolaus; Sbianchi, Giulia; Sirait, Tiarlan et al

in Leukemia (in press)

JAK1/2 inhibitor ruxolitinib (RUX) is approved in patients with myelofibrosis but the impact of pretreatment with RUX on outcome after allogeneic hematopoietic stem cell transplantation (HSCT) remains to ... [more ▼]

JAK1/2 inhibitor ruxolitinib (RUX) is approved in patients with myelofibrosis but the impact of pretreatment with RUX on outcome after allogeneic hematopoietic stem cell transplantation (HSCT) remains to be determined. We evaluated the impact of RUX on outcome in 551 myelofibrosis patients who received HSCT without (n = 274) or with (n = 277) RUX pretreatment. The overall leukocyte engraftment on day 45 was 92% and significantly higher in RUX responsive patients than those who had no or lost response to RUX (94% vs. 85%, p = 0.05). The 1-year non-relapse mortality was 22% without significant difference between the arms. In a multivariate analysis (MVA) RUX pretreated patients with ongoing spleen response at transplant had a significantly lower risk of relapse (8.1% vs. 19.1%; p = 0.04)] and better 2-year event-free survival (68.9% vs. 53.7%; p = 0.02) in comparison to patients without RUX pretreatment. For overall survival the only significant factors were age > 58 years (p = 0.03) and HLA mismatch donor (p = 0.001). RUX prior to HSCT did not negatively impact outcome after transplantation and patients with ongoing spleen response at time of transplantation had best outcome. [less ▲]

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See detailA machine learning-based methodology for identification of the plastic flow in aluminum sheets during incremental sheet forming processes
Pham, Quoc Tuan; Le, Hai Son; Nguyen, Anh Tuan et al

in The International Journal of Advanced Manufacturing Technology (in press)

This study presents a calibration method based on machine learning techniques to identify parameters of hardening law of aluminum alloy sheets in complex manufacturing processes. A V-shape test is ... [more ▼]

This study presents a calibration method based on machine learning techniques to identify parameters of hardening law of aluminum alloy sheets in complex manufacturing processes. A V-shape test is designed to characterize material behavior during an incremental sheet forming (ISF) process. A series of virtual materials is first generated using three physical features observed in a standard uniaxial tensile test: initial yield stress, maximum uniform plastic strain and yield-to-strength ratio. These virtual materials are then employed in simulating the designed V-shape tests to numerically collect the material responses, such as forming forces, displacements, or their combinations. Several feed-forward neural networks (FFNNs) are developed and trained to relate the collected material responses to the relevant virtual materials. Then, the trained FFNNs were used to estimate the flow curve of AA5052-H32 sheets up to a plastic strain value of 1.0 using the experimentally measured response from the V-shape test during ISF. The FFNN-based flow curves appear to capture well the stress–strain data obtained from the uniaxial tensile test with the coefficients of determination up to 0.98. The identified flow curves are also employed to simulate the uniaxial tensile and ISF truncated cone tests. The simulated uniaxial tensile forces are in good agreement with the experimentally measured results. A maximum difference of 5% is observed in the comparison between the simulated and measured ISF loading forces in the steady-state deformations. The comparisons demonstrate the efficiency of the proposed method to characterize the plastic flow of metal. [less ▲]

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See detailImplementation and Validation of a Model Predictive Controller on a Lab-scale Three-Terminal MTDC Grid
Belhaouane, Mohamed Moez; Almaksour, Khaled; Papangelis, Lampros et al

in IEEE Transactions on Power Delivery (in press)

In this paper, a reliable methodology is proposed in order to implement and validate a Model Predictive Control (MPC) scheme on an actual Voltage Source Converter (VSC) integrated in a scale-down multi ... [more ▼]

In this paper, a reliable methodology is proposed in order to implement and validate a Model Predictive Control (MPC) scheme on an actual Voltage Source Converter (VSC) integrated in a scale-down multi-terminal DC grid. The objective of the investigated MPC controller is to enable AC frequency support among two asynchronous AC areas through a High Voltage Direct Current (HVDC) grid, while considering physical constraints, such as maximum and minimum DC voltage. A systematic and accurate implementation strategy is proposed, based mainly on the Hardware In the Loop (HIL) and Power Hardware In the Loop (PHIL), leading to the real-life testing on VSC, controlled by a classical microcontroller. The technical problems during the implementation process, as well as the proposed solutions, are described in detail through this paper. This procedure is deemed valuable to bridge the gap between offline simulation and the actual implementation of such advanced control scheme on experimental test rig. [less ▲]

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See detailVocal beauty: a mediating variable in the negative stereotyping of dysphonic speakers
Verduyckt, Ingrid; Morsomme, Dominique ULiege

in Logopedics, Phoniatrics, Vocology (in press)

Context: A range of studies have consistently shown that listeners associate negative psychosocial characteristics to speakers with dysphonia. The reasons why have not formerly been explored. A better ... [more ▼]

Context: A range of studies have consistently shown that listeners associate negative psychosocial characteristics to speakers with dysphonia. The reasons why have not formerly been explored. A better understanding of the mechanisms behind this negative stereotype could help to develop attitude- changing measures towards voice disorders. Aim: We want to explore if the negative psychosocial stereotype linked to dysphonia is due to dys- phonia’s negative impact on perceived vocal beauty. Methods: A group of naïve listeners was asked to listen to female voice samples with varying degrees of dysphonia according to the Grade (G) of the GRBAS scale, and then to rate the perceived degree of vocal beauty for each voice on a visual analogue scale. They were also asked to infer personal charac- teristics of each speaker on a set of 21 Bipolar semantic scales. Results: Mediation analyses showed that G significantly and negatively predicts perceptions of vocal beauty (p < .001) and that vocal beauty in its turn was significantly and positively predicting inferences of negative psychosocial characteristics in the speakers (p<.001). When vocal beauty was partialled out, the negative impact of G was diminished or even cancelled. Conclusion: Our results show that in female speakers, the negative impact of dysphonia on the attri- bution of speakers’ personal characteristic is explained by the negative impact of dysphonia on per- ceived vocal beauty. Our results support the hypothesis that the beauty stereotype underlies the negative biases existing towards dysphonic speakers. We suggest that clinicians should be aware of this mechanism when promoting awareness about dysphonia. [less ▲]

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See detailRôles et impacts des pharmaciens en Belgique : une revue de littérature exploratoire
Frison, Corentin ULiege; Philippe, Geneviève ULiege; Mehuys, Els et al

in Pharmacien Hospitalier et Clinicien (in press)

Introduction > There is a growing number of articles describing the roles and impacts of the activity of pharmacists and their collaborators in the community and in health care settings. However, there is ... [more ▼]

Introduction > There is a growing number of articles describing the roles and impacts of the activity of pharmacists and their collaborators in the community and in health care settings. However, there is no profile of this literature related to pharmacy practice in Belgium. Method > This is a literature review. The main objective was to gather evidence in order to describe and highlight the different characteristics of the role of pharmacists and the impacts of their activities in Belgium. The literature search was carried out in three databases, PubMed, Embase and CINAHL between 01/01/2006 and 30/09/2019. Results > Of the 232 articles identified, 65 were included for analysis. The studies included only descriptive data (73.9%, 48/65) or descriptive data associated with measures of pharmacist impact (26.1%, 17/65). The study highlighted the presence of pharmacists exercising one or the other of the 21 pharmaceutical activities with, in descending order, medication reviews, advice to patients (i.e. ad hoc process that targets a drug), therapeutic education of patients (e.g. continuous, interdisciplinary process, which aims not only to inform but also to train and evaluate the patient) and drug reconciliation activities. Studies were conducted only in pharmacies (53.8%, 35/65), hospitals (29.2%, 19/65), both (7.7%, 5/65) and other practice settings (9.2%, 6/65). Seventeen of the 65 included studies included a measure of the impact of the pharmacist's presence. Of the 35 impact measures associated with pharmaceutical interventions, 23 included positive effects, 12 neutral effects and none of the negative effects. Conclusion > This is the first review of the literature on the roles and impacts of the pharmacist in Belgium. Sixty-five articles were selected, 17 of which included measures of the impact of pharmaceutical activity. Of the 35 impact measures associated with pharmaceutical interventions, 23 included positive effects, 12 neutral effects and none of the negative effects. These data are in phase with the action plan for the development of clinical pharmacy in Belgian hospitals for the period 2015–2020. [less ▲]

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