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Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1 beta and oncostatin M pre-treated non-sclerotic osteoblasts
Sanchez, Christelle; Deberg, Michelle; Piccardi, Nathalie et al.
2005 • In Osteoarthritis and Cartilage, 13 (11), p. 979-987

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OC_Coculture2005.pdf

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