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See detailLab meeting
Golestan Hashemi, Farahnaz Sadat ULiege

Report (2017)

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See detailAdvanced emulsion-templated porous polymers through controlled radical polymerization
Mathieu, Kevin ULiege

Doctoral thesis (2017)

Macroporous polymer monoliths are remarkable materials used in several applications such as supported catalysis, chromatography, water purification, gas capture, to name but a few. The emulsion-templated ... [more ▼]

Macroporous polymer monoliths are remarkable materials used in several applications such as supported catalysis, chromatography, water purification, gas capture, to name but a few. The emulsion-templated polymerization method, often based on conventional radical polymerization, is a very popular and straightforward approach for preparing such porous polymers. Nevertheless, the demand for more and more sophisticated porous supports with controlled porosity, good mechanical properties and specific surface properties, is increasing and requires the development of innovative synthesis strategies. The present thesis aims to explore the possible benefits of controlled radical polymerization (CRP) for the design of advanced macroporous monoliths via emulsion templated polymerization. In a general approach, copolymers with precise architecture, composition and chain-end functionality, were synthesized by CRP and used as macromolecular surfactants for stabilizing various types of high and medium internal phase emulsion polymerizations. A clear effect of the nature and concentration of the surfactants on the porous structures was emphasized. The physical and chemical anchoring of the macromolecular surfactants at the surface of the porous monoliths was also achieved allowing the functionalization of porous supports while preserving their openness. Finally, specific surfactants were designed by CRP for stabilizing CO2-in-ionic liquid (IL) emulsions which paved the way to the single step synthesis of unique and valuable macroporous poly(ionic liquid)s/ILs gels. Overall, the present work highlights the great potential of CRP for the emulsion-templated polymerization and the production of advanced functional macroporous monoliths. [less ▲]

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See detailReflexive Games, Distant Play: Challenging Immersion
Barnabé, Fanny ULiege

Scientific conference (2017, December 08)

Immersion is an omnipresent concept in the field of video games: it appears in the players’ debates, in the discourses of the industry, in the press and in the academic research. For developers and ... [more ▼]

Immersion is an omnipresent concept in the field of video games: it appears in the players’ debates, in the discourses of the industry, in the press and in the academic research. For developers and journalists, immersion is a recurrent promise repeated at every technological turn: the promise that, one day, technology will allow us to literally enter the fictional worlds. In the academic field, the term is also at the centre of many works: researchers in game studies frequently use the concept of immersion to describe the playing activity as a “diving” into a video game universe. However, this notion gives rise to several epistemological issues. First, the word immersion continues to convey negative preconceptions against play and fiction, keeping alive the idea that they are alienating practices. Secondly, in the video games domain, the concept is extremely vague and shape-shifting. Besides, researchers rarely question the desirability of the immersion state: it is most often postulated as the purpose and as the enviable horizon of any gaming practice. As a consequence, the concepts of immersion, fun, pleasure and even of play end up getting confused and superimposed into the theories. This paper will defend the idea that it is necessary to escape from the theoretical paradigm of “immersion”: on the one hand, because it presents some incompatibility with the theories of play, and, on the other hand, because it prevents us from describing the many other forms of relationship that players can have with games. [less ▲]

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See detailThe virion transmembrane proteome: a glance to the evolution and to the biology of Cyprinid herpesvirus 3
Vancsok, Catherine ULiege

Doctoral thesis (2017)

Cyprinid herpesvirus 3 (CyHV-3) is the etiological agent of a highly contagious and lethal disease affecting koi and common carp worldwide. Beyond its economic importance, this virus turned out to be an ... [more ▼]

Cyprinid herpesvirus 3 (CyHV-3) is the etiological agent of a highly contagious and lethal disease affecting koi and common carp worldwide. Beyond its economic importance, this virus turned out to be an interesting subject for fundamental research and is currently considered as the archetype of Alloherpesviridae. The divergence of this family with the Herpesviridae is ancestral, with almost no significant homology between CyHV 3 genes and those of Herpesviridae. Consequently, the extensive knowledge acquired for the latter cannot be used to predict CyHV 3 biological features. Virion transmembrane proteins (VTPs) are well documented in Herpesviridae for their involvement in crucial processes such as entry, immune evasion, morphogenesis and egress of progeny virions from the host cells. In contrast, very little is known about the functions of these proteins in CyHV 3 or in any of the alloherpesviruses. The main objective of this thesis was to provide a first functional characterization of CyHV-3 virion transmembrane proteome. The experimental work performed is summarized in two main chapters. The first study aimed to update the list of known CyHV-3 VTPs and to determine those that are essential to viral growth in vitro. Using mass spectrometry approaches and mutagenesis experiments, we identified 16 VTPs in the CyHV-3 FL strain, among which 8 turned out to be essential to viral growth in vitro. The non-essential VTPs were further assessed quantitatively for their relative importance in vitro and in vivo. ORF25, ORF64, ORF108, ORF132, ORF136, ORF148, and ORF149 were shown to affect viral growth in vitro; while the lack of ORF148 or ORF25 caused attenuation to a minor or major extent in vivo, respectively. Finally, we showed that a mutant lacking ORF25 was highly attenuated but induced a moderate immune protection under the conditions tested. Bioinformatic analyses suggested that CyHV-3 ORF27 encodes a VTP. However, no protein corresponding to this ORF was detected in our proteomic analyses. Analyses of genome sequence and protein expression demonstrate that the FL strain, like several other laboratory strains, do not express ORF27 due to presence of various mutations, while it encodes a VTP in field strains. These observation led us to hypothesize that the deletion of ORF27 could confer a selective advantage to viral growth in vitro, while the expression of a functional pORF27 could confer a selective advantage in vivo. These hypotheses were addressed by producing recombinant viruses. In vitro, the CyHV 3 strain lacking ORF27 expression was shown to have a replicative advantage, especially during co-infection with a viral strain expressing this protein. In contrast, in vivo, no difference between both genotypes could be detected in the experimental conditions tested. This observation suggests that the biological functions of ORF27 cannot be revealed in the laboratory conditions used. In conclusion, this thesis provides a first functional characterization of the virion transmembrane proteome of CyHV-3. It represents a firm basis for further research on alloherpesvirus VTPs. [less ▲]

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See detailTourbières d'altitude en Haute Savoie
Streel, Maurice ULiege; David, Fernand; Roche, Emile ULiege et al

Conference (2017, December 08)

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See detailSouth American miospore evolution, from their first appearance up to the Early Devonian
Steemans, Philippe ULiege; Garcia Muro, VJ; Gerrienne, Philippe ULiege et al

Conference (2017, December 08)

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See detailFirst spore data of the Upper Devonian Bolloncillos Formation (NE Iberian Peninsula)
Cascales-Miñana, Borja ULiege; Steemans, Philippe ULiege; Rial, G et al

Conference (2017, December 08)

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See detailMiscellanea palaeontologica 2017
Steemans, Philippe ULiege; Gerrienne, Philippe ULiege

Book published by University of Liège (2017)

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See detailTowards a system of concepts for Family Medicine. Multilingual indexing in General Practice/ Family Medicine in the era of Semantic Web
Jamoulle, Marc ULiege

Doctoral thesis (2017)

UNIVERSITY OF LIÈGE, BELGIUM Executive Summary Faculty of Medicine Département Universitaire de Médecine Générale. Unité de recherche Soins Primaires et Santé Doctor in biomedical sciences Towards a ... [more ▼]

UNIVERSITY OF LIÈGE, BELGIUM Executive Summary Faculty of Medicine Département Universitaire de Médecine Générale. Unité de recherche Soins Primaires et Santé Doctor in biomedical sciences Towards a system of concepts for Family Medicine. Multilingual indexing in General Practice/ Family Medicine in the era of SemanticWeb by Dr. Marc JAMOULLE Introduction This thesis is about giving visibility to the often overlooked work of family physicians and consequently, is about grey literature in General Practice and Family Medicine (GP/FM). It often seems that conference organizers do not think of GP/FM as a knowledge-producing discipline that deserves active dissemination. A conference is organized, but not much is done with the knowledge shared at these meetings. In turn, the knowledge cannot be reused or reapplied. This these is also about indexing. To find knowledge back, indexing is mandatory. We must prepare tools that will automatically index the thousands of abstracts that family doctors produce each year in various languages. And finally this work is about semantics1. It is an introduction to health terminologies, ontologies, semantic data, and linked open data. All are expressions of the next step: Semantic Web for health care data. Concepts, units of thought expressed by terms, will be our target and must have the ability to be expressed in multiple languages. In turn, three areas of knowledge are at stake in this study: (i) Family Medicine as a pillar of primary health care, (ii) computational linguistics, and (iii) health information systems. Aim • To identify knowledge produced by General practitioners (GPs) by improving annotation of grey literature in Primary Health Care • To propose an experimental indexing system, acting as draft for a standardized table of content of GP/GM • To improve the searchability of repositories for grey literature in GP/GM. 1For specific terms, see the Glossary page 257 x Methods The first step aimed to design the taxonomy by identifying relevant concepts in a compiled corpus of GP/FM texts. We have studied the concepts identified in nearly two thousand communications of GPs during conferences. The relevant concepts belong to the fields that are focusing on GP/FM activities (e.g. teaching, ethics, management or environmental hazard issues). The second step was the development of an on-line, multilingual, terminological resource for each category of the resulting taxonomy, named Q-Codes. We have designed this terminology in the form of a lightweight ontology, accessible on-line for readers and ready for use by computers of the semantic web. It is also fit for the Linked Open Data universe. Results We propose 182 Q-Codes in an on-line multilingual database (10 languages) (www.hetop.eu/Q) acting each as a filter for Medline. Q-Codes are also available under the form of Unique Resource Identifiers (URIs) and are exportable in Web Ontology Language (OWL). The International Classification of Primary Care (ICPC) is linked to Q-Codes in order to form the Core Content Classification in General Practice/Family Medicine (3CGP). So far, 3CGP is in use by humans in pedagogy, in bibliographic studies, in indexing congresses, master theses and other forms of grey literature in GP/FM. Use by computers is experimented in automatic classifiers, annotators and natural language processing. Discussion To the best of our knowledge, this is the first attempt to expand the ICPC coding system with an extension for family physician contextual issues, thus covering non-clinical content of practice. It remains to be proven that our proposed terminology will help in dealing with more complex systems, such as MeSH, to support information storage and retrieval activities. However, this exercise is proposed as a first step in the creation of an ontology of GP/FM and as an opening to the complex world of Semantic Web technologies. Conclusion We expect that the creation of this terminological resource for indexing abstracts and for facilitating Medline searches for general practitioners, researchers and students in medicine will reduce loss of knowledge in the domain of GP/FM. In addition, through better indexing of the grey literature (congress abstracts, master’s and doctoral theses), we hope to enhance the accessibility of research results and give visibility to the invisible work of family physicians. [less ▲]

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See detailInteractions between stereotype threat, subjective aging, and memory in older adults
Marquet, Manon ULiege; Missotten, Pierre ULiege; Dardenne, Benoît ULiege et al

in Aging, Neuropsychology, and Cognition (2017)

This study examined whether the effects of stereotype threat on memory and subjective age were moderated by positive age stereotypes and self-perceptions of aging among older adults. Perceived threat as a ... [more ▼]

This study examined whether the effects of stereotype threat on memory and subjective age were moderated by positive age stereotypes and self-perceptions of aging among older adults. Perceived threat as a mechanism underlying these effects was also explored. Results showed that stereotype threat (high vs. low threat) did not affect the dependent variables. Moreover, self-perceptions of aging did not moderate the effect of stereotype threat on the dependent variables. However, for people with more positive age stereotypes, older people under high threat perceived more threat than people under low threat. This could be explained by an effect of age stereotypes in the high-threat group: the more positive age stereotypes held by participants, the more they perceived threat, which in turn decreased their memory performance and made them feel mentally older. We hypothesized that age group identity is stronger in people with more positive age stereotypes, which increase perceived threat. [less ▲]

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See detailEpidemiology of urolithiasis in Liège according to morpho-constitutional classification
Castiglione, Vincent ULiege

Conference (2017, December 08)

Background Stone components are various and influenced by acquired and inherited factors. Hence we describe the distribution of stone composition in Belgium according to age and sex. Methods We ... [more ▼]

Background Stone components are various and influenced by acquired and inherited factors. Hence we describe the distribution of stone composition in Belgium according to age and sex. Methods We retrospectively reviewed 1869 urinary stones analyzed between 2010 and 2013 at the laboratory of the CHU of Liège (Belgium). Samples were assessed by infrared spectroscopy, and morphology was used to classify stones in morpho-constitutional types according to Daudon classification. Results Among 1869 stones, 69.2% affected men. The prevalence peak was observed between 50–60 years of age in both genders. The main constituent was calcium oxalate monohydrate (54.4%), mainly organized as type Ia (94%). Calcium oxalate dihydrate was found in 19.8% samples, with an equal distribution between types IIa and IIb. Uric acid was the 3rd most frequent constituent in man (10.8%), instead of phosphates in woman (26.6%). Urinary infection may be the main cause of stone formation in 6% of patients. Multiple morphological types were concomitantly identified in 49.3% of stones. The proportion of calcium oxalate dihydrate stones decreased with aging, while monohydrate and uric acid increased in both genders. Conclusion This retrospective analysis of urinary stones helps for the first time to characterize the epidemiology of urolithiasis in Belgium. [less ▲]

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See detailA new look at some Late Devonian floras from Eastern Europe
Snigirevsky, S.M.; Meyer-Berthaux, B.; Steemans, Philippe ULiege et al

Conference (2017, December 08)

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See detailManagement of Respiratory Infections with Use of Procalcitonin: Moving toward More Personalized Antibiotic Treatment Decisions.
Wirz, Yannick; Branche, Angela; Wolff, Michel et al

in ACS infectious diseases (2017), 3(12), 875-879

Due to overlap of clinical findings and low sensitivity of bacterial diagnostic tests, differentiation between bacterial and viral respiratory tract infections remains challenging, ultimately leading to ... [more ▼]

Due to overlap of clinical findings and low sensitivity of bacterial diagnostic tests, differentiation between bacterial and viral respiratory tract infections remains challenging, ultimately leading to antibiotic overuse in this population of patients. Addition of procalcitonin, a blood biomarker expressed by epithelial cells in response to bacterial infections, to the clinical assessment leads to a reduction in inappropriate antibiotic initiation. Procalcitonin also provides prognostic information about the resolution of illness, and significant decreases over time are a strong signal for the discontinuation of antibiotics. Current evidence from randomized trials indicates that procalcitonin-guided antibiotic stewardship results in a reduction in antibiotic use and antibiotic side effects, which importantly translates into improved survival of patients with respiratory infections. Inclusion of procalcitonin into antibiotic stewardship algorithms thus improves the diagnostic and therapeutic management of patients presenting with respiratory illnesses and holds great promise to mitigate the global bacterial resistance crisis. [less ▲]

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