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See detailDébit de filtration glomérulaire : estimations et mesures
DELANAYE, Pierre ULiege

Scientific conference (2017, November 24)

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See detailOral calcium load test for recurrent calcium stone-formers
Castiglione, Vincent ULiege; CAVALIER, Etienne ULiege

Conference (2017, November 24)

Background Calcium is the most frequent component of urinary stones, and hypercalciuria is the main risk factor in recurrent stone-formers. The oral calcium load test is a dynamical biological test that ... [more ▼]

Background Calcium is the most frequent component of urinary stones, and hypercalciuria is the main risk factor in recurrent stone-formers. The oral calcium load test is a dynamical biological test that determines the origin of hypercalciuria in order to optimize the treatment. However, there is little literature about it, and it seems to have lost popularity in daily practice, this why we studied a population of stone-formers who underwent the oral calcium load test. Methods Between 2013 and 2016, we prospectively recruited 117 recurrent calcium stone-formers. After 2 days of calcium restricted-diet, patients had urinary and blood sampling at baseline and 120 min after the intake of 1 g of calcium per os. Blood and urinary parameters were assessed during the dynamical test, including stone risk factors, calcium metabolism and bone evaluation. According to these results, patients were classified in three groups: resorptive, renal or absorptive hypercalciuria. Results First, 19 patients were diagnosed with normocalcemic primary hyperparathyroidism, assessed by inappropriate parathormone decrease (41.41±12.82 vs. 54.06±13.84% p<0.01) in regard to calcemia. The measurement of ionized calcium was mandatory in order to detect induced hypercalcemia after calcium intake. These patients also had higher beta-crosslaps, lower phosphate reabsorption threshold and lower distal third radius bone mineral density. The treatment of this first group of patient is the hyperparathyroïdectomy. Fasting hypercalciuria was present in 39 patients with urinary calcium >0.37mmol/mmol of creatinine, and without hyperparathyroidism, classified thus as renal hypercalciuria. The treatment of these patients should include adapted calcium intake and thiazids. The third group included 34 patients with absorptive hypercalciuria defined by the presence of delta urinary calcium/creatinine <0.6mmol/mmol between 0 and 120 min, and without any other significant abnormality. Finally, the test result was not reliable for 33 cases because of the absence of sufficient calcemia increase or when the cause of lithogenesis could not be clearly identified. Conclusions The oral calcium load test was successful for the identification of main metabolic conditions leading to urolithiasis, including normocalcemic primary hyperparathyroidism, and is useful to improve and personalize the treatment of stone-formers. [less ▲]

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See detailOral calcium load test for recurrent calcium stone-formers
Castiglione, Vincent ULiege; CAVALIER, Etienne ULiege

Poster (2017, November 24)

Background Calcium is the most frequent component of urinary stones, and hypercalciuria is the main risk factor in recurrent stone-formers. The oral calcium load test is a dynamical biological test that ... [more ▼]

Background Calcium is the most frequent component of urinary stones, and hypercalciuria is the main risk factor in recurrent stone-formers. The oral calcium load test is a dynamical biological test that determines the origin of hypercalciuria in order to optimize the treatment. However, there is little literature about it, and it seems to have lost popularity in daily practice, this why we studied a population of stone-formers who underwent the oral calcium load test. Methods Between 2013 and 2016, we prospectively recruited 117 recurrent calcium stone-formers. After 2 days of calcium restricted-diet, patients had urinary and blood sampling at baseline and 120 min after the intake of 1 g of calcium per os. Blood and urinary parameters were assessed during the dynamical test, including stone risk factors, calcium metabolism and bone evaluation. According to these results, patients were classified in three groups: resorptive, renal or absorptive hypercalciuria. Results First, 19 patients were diagnosed with normocalcemic primary hyperparathyroidism, assessed by inappropriate parathormone decrease (41.41±12.82 vs. 54.06±13.84% p<0.01) in regard to calcemia. The measurement of ionized calcium was mandatory in order to detect induced hypercalcemia after calcium intake. These patients also had higher beta-crosslaps, lower phosphate reabsorption threshold and lower distal third radius bone mineral density. The treatment of this first group of patient is the hyperparathyroïdectomy. Fasting hypercalciuria was present in 39 patients with urinary calcium >0.37mmol/mmol of creatinine, and without hyperparathyroidism, classified thus as renal hypercalciuria. The treatment of these patients should include adapted calcium intake and thiazids. The third group included 34 patients with absorptive hypercalciuria defined by the presence of delta urinary calcium/creatinine <0.6mmol/mmol between 0 and 120 min, and without any other significant abnormality. Finally, the test result was not reliable for 33 cases because of the absence of sufficient calcemia increase or when the cause of lithogenesis could not be clearly identified. Conclusions The oral calcium load test was successful for the identification of main metabolic conditions leading to urolithiasis, including normocalcemic primary hyperparathyroidism, and is useful to improve and personalize the treatment of stone-formers. [less ▲]

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See detailRare Sulfamethoxazole Crystalluria – case report
Castiglione, Vincent ULiege; Diop, Coumba Souley ULiege; CAVALIER, Etienne ULiege et al

Poster (2017, November 24)

Case discussion We report here 7 Caucasian patients with very uncommon crystalluria. There were 3 female and 4 male of 54 to 86 years-old. Patients had no relevant medical record in common. However, they ... [more ▼]

Case discussion We report here 7 Caucasian patients with very uncommon crystalluria. There were 3 female and 4 male of 54 to 86 years-old. Patients had no relevant medical record in common. However, they all were hospitalized for different types of infections: three patients had urinary infection, two had osteitis, and the two last had sepsis. The patients had all been first treated with different antibiotherapy, which had then been replaced by cotrimoxazole after antibiogram. The administrated doses varied from 800mg to 4800mg a day of Sulfamethoxazole. Crystalluria description In all patients, the urine microscopic analysis revealed unusual crystals of various shapes including rectangles, thick parallelepipeds, truncated lozenges, spheroids, mushrooms, or “flowers”. Some crystals were incorrectly identified by the urinary sediment analyzer as uric acid, but we sought to determine them accurately. Most of the crystals were strongly birefringent and measured between 20 and 100µm. Urine pH varied from 5.0 to 6.5 on strip analysis. After urine centrifugation, we performed infrared spectrophotometry analysis on dried residue. In all cases, the infrared spectra allowed us to identify the N-acetyl-Sulfamethoxazole, the main metabolite of Sulfamethoxazole. Crystalluria was observed between 1 and 26 days after Sulfamethoxazole treatment initiation. The serum creatinine increased from 16% to 88% in 3 patients between the first day of Sulfamethoxazole treatment and the day of crystalluria. These considerations raised concern for drug implication in renal failure in some of these patients. Teaching points for the clinical condition Drug-induced kidney failure is well-known, but the direct precipitation of drug crystals into tubules is rare, and also probably under-evaluated. Even if Sulfamethoxazole tubular precipitation was probably not the main cause of renal failure in these cases, we suspect it could have played a role. N-Acteyl-Sulfamethoxazole can precipitate in urine in many uncommon crystals shapes that raise suspicion for drug nephrotoxicity. Automated urine analyzers may misidentify these rare crystals. Crystal’s recognition may be difficult even with polarized light microscopy. This is why they must be identified by infrared spectrophotometry to avoid misdiagnosis. These renal failures linked to Sulfamethoxazole precipitation are more susceptible to appear with high dosage of drug, hypovolemia and pre-existing renal failure. Hypoalbuminemia has also been described as a risk factor and was present in our four patients (between 26 to 39g/l, range laboratory: 43-54). Thus, prevention of Sulfamethoxazole precipitation consists in hydratation to maintain urine flow, and require adaptation of cotrimoxazole dosage in regard of renal function. Urine alkalinization (pH >7.0) is also possible in order to increase Sulfamethoxazole metabolite solubility. [less ▲]

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See detailModelling ice flow for large-scale ice-sheet simulations
Bulthuis, Kevin ULiege; Arnst, Maarten ULiege; Pattyn, Frank

Diverse speeche and writing (2017)

General introduction to ice-flow modelling for ice-sheet simulations

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See detailLa cellule de son centrosome jusqu'à sa paroi a inspiré la recherche en biologie à l'université de Liège
Thiry, Marc ULiege

in Bulletin de la Société Royale des Sciences (2017, November 24)

Detailed reference viewed: 11 (2 ULiège)
Peer Reviewed
See detailHarmful tax competition within the European Union: from tax rulings to financial transaction taxes
Van Cleynenbreugel, Pieter ULiege

Conference (2017, November 24)

In this presentation, I will outline how the EU constitutional framework reacts against harmful tax competition, in addition to showcasing the limits and negative consequences of that approach.

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See detailCiné-débat: Merci pour la pluie
Wellens, Joost ULiege

Conference given outside the academic context (2017)

Detailed reference viewed: 17 (3 ULiège)
See detailLa Nature à ses plis. Architectonique des formes naturelles de Leibniz à Geoffroy Saint-Hilaire.
Dony, Arthur ULiege

Scientific conference (2017, November 24)

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See detailQuelle place pour l’intégration des TICE dans l’organisation de la formation initiale des enseignants ?
Laduron, Christophe ULiege; Denis, Brigitte ULiege; Rappe, Jonathan ULiege

Conference (2017, November 24)

Depuis plus de vingt ans, l'intégration des TICE dans les pratiques pédagogiques a régulièrement fait l'objet d’études et réflexions. Les plans stratégiques oeuvrant à l’incorporation des TICE et ... [more ▼]

Depuis plus de vingt ans, l'intégration des TICE dans les pratiques pédagogiques a régulièrement fait l'objet d’études et réflexions. Les plans stratégiques oeuvrant à l’incorporation des TICE et insistant sur la nécessité de former les équipes éducatives, d’équiper les écoles se sont également multipliés. De son côté, la formation initiale et continue des enseignants à l’intégration des TICE est devenue une des préoccupations européennes. Les stratégies liées à la formation initiale des futurs enseignants en termes d’intégration des TICE restent cependant à consolider, dépendant elles-mêmes de différentes niveaux de pouvoir, de l’influence plus ou moins importante des lobbys commerciaux, des politiques institutionnelles en matière de formation initiale des enseignants (Université, Haute École, etc.), des réglementations en termes de formation continue (obligatoire, sectorielle, etc.), du statut des TICE à l’école, etc. Cette contribution interroge plus particulièrement l’évolution que prendra la formation à l’intégration des TICE en Fédération Wallonie-Bruxelles, dans le contexte d’une réforme de la formation initiale des enseignants dont les bases ont été jetées, mais doivent être approfondies et négociées et la mise en place à construire. Les cours « Utilisation de l’ordinateur et Apport des Médias et des TIC en Enseignement » (AMTICE) seront-ils maintenus ? Le curriculum du cours AMTICE va- t-il être servir de référence ? Qui le fera évoluer ? Quels seront les types de dispositifs de formation proposés aux futurs enseignants ? Le dispositif de recherche-action mis en place par les auteurs tentera dans un premier temps de clarifier et cibler l’ensemble des invariants liés à l’élaboration et à l’administration du cours AMTICE, et dans un second temps de tester et éprouver les modalités avec lesquelles les auteurs envisagent de diffuser et partager le fruit de ce recensement auprès des professeurs AMTICE désireux de développer leurs pratiques. [less ▲]

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See detailLes voyages d’étude dans l’accompagnement professionnel : le cas de visites de crèches à Gand
Pirard, Florence ULiege; Delaval, Elodie; GOOSSENS, Xavier

Scientific conference (2017, November 24)

La communication traite de la place des voyages d’étude dans l'accompagnement de professionnel-le-s de la petite enfance, quand ce dernier a une double visée de développement professionnel et de qualité ... [more ▼]

La communication traite de la place des voyages d’étude dans l'accompagnement de professionnel-le-s de la petite enfance, quand ce dernier a une double visée de développement professionnel et de qualité de services. Il s’appuie sur l’analyse rétrospective d’un dispositif d’accompagnement d’accueillantes et d’encadrantes mis en œuvre en Fédération Wallonie-Bruxelles. La recherche présentée ici vise plus particulièrement à mieux comprendre les sens et les significations accordés par les participants de 14 équipes de crèches aux voyages d’étude inscrits dans un dispositif d’accompagnement professionnel et à identifier les freins et facilitateurs au changement de pratiques [less ▲]

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See detailGenotype and protein level interaction in growth traits of meat-type quail through reaction norm models
da Costa Caetano, G.; Fonseca Silva, F.; Calderano, A. et al

in Journal of Animal and Feed Sciences (2017), 26

One possible strategy to optimize breeding programmes in terms of feed costs is selecting animals based on their genetic performance over protein levels (PL). A genotype and environment (G×E) interaction ... [more ▼]

One possible strategy to optimize breeding programmes in terms of feed costs is selecting animals based on their genetic performance over protein levels (PL). A genotype and environment (G×E) interaction in which the gradual environmental changes are represented by the respective PL is such a strategy. Reaction norm models (RNM) are suitable to perform these analyses, since they enable to evaluate genetic differences among animals as well as variance components and heritability estimates over PL. The aim of the study was to investigate the G and PL interaction in two meat-type quail lines (UFV1 and UFV2) for their body weight at day 28 (BW28) and 35 (BW35) of age by using RNM. Diets were composed in order to have different PL (22, 23, 24, 25, 26, 27, 28 and 29%) but the same metabolizable energy (2900 kcal) by keeping constant amino acids : lysine ratio for animal performance. The data set contained 970 and 410 animals from UFV1 and UFV2 lines, respectively. Several RNM (with different Legendre polynomial orders and residual variance classes) were compared via Akaike (AIC) and Schwarz Bayesian (BIC) information criteria. The RNM outperformed (lower AIC and BIC values) the traditional model disregarding G×E and suggested G×PL interaction for BW28 and BW35. The observed moderate-to-high heritabilities increased over PL, thus proving the existence of G×PL for growth traits in meat-type quail. [less ▲]

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See detailInvasive plants as potential food resource for native pollinators: A case study with two invasive species and a generalist bumble bee
Drossart, Maxime; Michez, Denis; Vanderplanck, Maryse ULiege

in Scientific Reports (2017)

It is now well established that invasive plants may induce drifts in the quantity and/or quality of floral resources. They are then often pointed out as a potential driver of bee decline. However, their ... [more ▼]

It is now well established that invasive plants may induce drifts in the quantity and/or quality of floral resources. They are then often pointed out as a potential driver of bee decline. However, their impact on bee population remains quite unclear and still controversial, as bee responses are highly variable among species. Here, we compared the amino acid composition of pollen from three native and two invasive plant species included in diets of common pollinators in NW Europe. Moreover, the nutritional intake (i.e., pollen and amino acid intakes) of Bombus terrestris colonies and the pollen foraging behaviour of workers (i.e., visiting rate, number of foraging trips, weight of pollen loads) were considered. We found significant differences in pollen nutrients among the studied species according to the plant invasive behaviour. We also found significant differences in pollen foraging behaviour according to the plant species, from few to several foraging trips carrying small or large pollen loads. Such behavioural differences directly impacted the pollen intake but depended more likely on plant morphology rather than on plant invasive behaviour. These results suggest that common generalist bumble bees might not always suffer from plant invasions, depending on their behavioural plasticity and nutritional requirements. [less ▲]

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See detailFive years of harvest with the vortex coronagraph
Absil, Olivier ULiege

Scientific conference (2017, November 24)

While the concept of vortex coronagraphy dates back to 2005, the first science-grade Annular Groove Phase Masks (AGPM), working in the thermal infrared regime, have been installed at the VLT only in 2012 ... [more ▼]

While the concept of vortex coronagraphy dates back to 2005, the first science-grade Annular Groove Phase Masks (AGPM), working in the thermal infrared regime, have been installed at the VLT only in 2012. They are now also equipping the Keck telescope and the Large Binocular Telescope, and will soon be at the core of more ground-based high-contrast imaging instruments. In this seminar, I will shortly review the technology development undertaken over the last 12 years, and describe the on-sky operations and performance of the vortex coronagraph. I will then present the main scientific results obtained since 2012, and explain how we have recently adapted deep learning techniques to the problem of post-processing in high-contrast imaging. I will finally discuss the perspectives with new instruments, including the Breakthrough Watch project. [less ▲]

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See detailLe développement de Communautés de Pratique ‘sollicitées’: indicateurs de succès et freins
Noben, Natasha ULiege

Conference (2017, November 24)

In line with the European project PALETTE (Pedagogically sustained Adaptative LEarning Through the exploitation of Tacit and Explicit Knowledge), Health CoP aims at supporting the development of ... [more ▼]

In line with the European project PALETTE (Pedagogically sustained Adaptative LEarning Through the exploitation of Tacit and Explicit Knowledge), Health CoP aims at supporting the development of Communities of Practice between professionals from the health domain. Specifically addressing the case of hybrid,"elicited" and extra-organizational communities, this study analyses the success indicators and obstacles identified in the literature and proposes to complete them in light of the learnings from the Health CoP experience. These indicators of success and obstacles are then structured according to the stages of a CoP's life cycle. [less ▲]

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See detailLa mission Cassini-Huygens: Récit de 13 années d'observation des merveilles de Saturne
Palmaerts, Benjamin ULiege

Conference given outside the academic context (2017)

Le 15 septembre dernier, la sonde Cassini a plongé dans l’atmosphère de Saturne, mettant un point final à la fructueuse mission spatiale Cassini-Huygens. Durant cette mission sans précédent, Cassini a ... [more ▼]

Le 15 septembre dernier, la sonde Cassini a plongé dans l’atmosphère de Saturne, mettant un point final à la fructueuse mission spatiale Cassini-Huygens. Durant cette mission sans précédent, Cassini a passé 13 années autour de Saturne, étudiant sans relâche la planète, ses anneaux, ses lunes, notamment Titan grâce à la sonde Huygens, et son environnement spatial. Dans cette présentation, après une brève introduction sur la genèse de la mission dans les années 80 et 90, je reviendrai sur les importantes découvertes réalisées par Cassini. La présentation sera illustrée par les nombreuses images prises durant la mission, notamment les premières images de la surface de Titan, dissimulée sous une épaisse atmosphère. Une large partie de l’exposé sera consacrée à la lune Encelade qui a réservé de multiples surprises à Cassini, notamment la présence d’un océan liquide sous sa couche glacée au sein duquel de la vie pourrait s’être développée. Les grandes avancées sur la compréhension de l’évolution des anneaux seront aussi abordées, de même que la dynamique de l’atmosphère et la magnétosphère de Saturne. [less ▲]

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See detailEnjeux de gouvernance métropolitaine et fragmentation territoriale
Breuer, Christophe ULiege

Conference (2017, November 24)

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Peer Reviewed
See detailDo leisures activities and rest-activity rythm explain executive performance in aging?
Collette, Fabienne ULiege; Lesoinne, Alexia ULiege; Gilsoul, Jessica ULiege et al

Conference (2017, November 24)

There exists a large inter-individual variability regarding the effects of aging on cognition. Sleep-wake rhythms and cognitive reserve may contribute to explain why some people appear to be more ... [more ▼]

There exists a large inter-individual variability regarding the effects of aging on cognition. Sleep-wake rhythms and cognitive reserve may contribute to explain why some people appear to be more resistant to the effects of aging than others. Particularly, individuals who have developed a high level of reserve resist better to the effects of aging than individuals with lower cognitive reserve. Conversely, a decrease of day-to-day stability of sleep-wake rhythms and an increase of sleep fragmentation may contribute to potentiate the effects of aging. In this study, we describe the impact of cognitive reserve and rest-activity rhythm on executive functions in normal aging. One hundred and sixty five healthy participants aged from 59 to 81 years were recruited. We assessed the three major executive functions: Inhibition (Stroop test, Hayling test, TAP Incompatibility subtest), Shifting (TAP Flexibility subtest, Plus-Minus task), and Updating (Letter-Number Sequencing subtest from MEM III, Letter memory task, 2-back task). Cognitive reserve was measured by questionnaires assessing leisure activities across the lifespan. Actigraphy was used to measure parameters of sleep-wake cycle (24-h fragmentation and 24-h stability) over a minimal period of 12 days. In a first model, multiple linear regressions (p<0.05) adjusted for age, Mattis score and processing speed showed that education did not explained executive performance. Conversely, current practice of at least one social leisure activity has a positive impact on flexibility and a minimum of 3 intellectual activities or a minimum of two social activities regularly performed are necessary to have a positive impact on updating. In a second model adjusted for age, Mattis score and processing speed and formal education, we did not observed a significant effect of day-to-day stability and sleep fragmentation on executive functioning. These results suggest that the cognitive reserve is related to abilities in some executive tests while rest-activity rhythm does not seem to explain the inter-individual variability of executive performance. [less ▲]

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