Joris, T., Jouant, T., Jacques, J.-R., Gouverneur, L., Saintmard, X., Vilanova Mana, L., Jamakhani, M., Reichert, M., & Willems, L. (November 2024). Reduction of antisense transcription affects bovine leukemia virus replication and oncogenesis. PLoS Pathogens, 20 (11), 1012659. doi:10.1371/journal.ppat.1012659 |
Willems, M.* , Hamaïdia, M.* , Fontaine, A., Grégoire, M., Halkin, L., Vilanova Mana, L., Terres, R., Jamakhani, M., Deshayes, S., Brostaux, Y., HEINEN, V., LOUIS, R., Duysinx, B., Jean, D., Wasielewski, E., Scherpereel, A., Blanquart, C., & Willems, L. (28 October 2024). The impact of Charcot-Leyden Crystal protein on mesothelioma chemotherapy: targeting eosinophils for enhanced chemosensitivity. EBioMedicine, 109, 105418. doi:10.1016/j.ebiom.2024.105418 * These authors have contributed equally to this work. |
Porquet, F., Weidong, L., Jehasse, K., Gazon, H., Kondili, M., Blacher, S., Massotte, L., Di Valentin, E., Furling, D., Gillet, N., Klein, A. F., Seutin, V., & Willems, L. (2023). Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy: Nucleic Acids, 32, 857 - 871. doi:10.1016/j.omtn.2023.05.007 |
Willems, M., Scherpereel, A., Wasielewski, E., Raskin, J., Brossel, H., Fontaine, A., Grégoire, M., Halkin, L., Jamakhani, M., Heinen, V., Louis, R., Duysinx, B., Hamaïdia, M.* , & Willems, L.*. (2023). Excess of blood eosinophils prior to therapy correlates with worse prognosis in mesothelioma. Frontiers in Immunology, 14, 1148798. doi:10.3389/fimmu.2023.1148798 * These authors have contributed equally to this work. |
Hoyos, C.* , Fontaine, A.* , Jacques, J.-R., Heinen, V., Louis, R., Duysinx, B., Scherpereel, A., Wasielewski, E., Jamakhani, M.* , Hamaïdia, M.* , & Willems, L.*. (2022). HDAC Inhibition with Valproate Improves Direct Cytotoxicity of Monocytes against Mesothelioma Tumor Cells. Cancers, 14 (9), 2164. doi:10.3390/cancers14092164 * These authors have contributed equally to this work. |
Suárez Archilla, G., Gutiérrez, G., Camussone, C., Calvinho, L., Abdala, A., Alvarez, I., Petersen, M., Franco, L., Destefano, G., Monti, G., Jacques, J.-R., Joris, T., Willems, L.* , & Trono, K.*. (2022). A safe and effective vaccine against bovine leukemia virus. Frontiers in Immunology, 13, 980514. doi:10.3389/fimmu.2022.980514 * These authors have contributed equally to this work. |
Hoyos, C., Fontaine, A., Brossel, H., Willems, M., Jamakhani, M., Vandermeers, F., Safari, R., HEINEN, V., LOUIS, R., DUYSINX, B., Scherpereel, A., Wasielewski, E., Mascaux, C., Hamaïdia, M.* , & Willems, L.*. (14 December 2021). Contribution of lysine deacetylases to the therapy of malignant pleural mesothelioma [Poster presentation]. Giga Cancer Day, Liège, Belgium. * These authors have contributed equally to this work. |
Willems, M., Jamakhani, M., Scherpereel, A., Wasielewski, E., Brossel, H., Fontaine, A., Hoyos, C., Grégoire, M., Louis, R., Duysinx, B., Hamaïdia, M.* , & Willems, L.*. (14 December 2021). Eosinophils inhibit malignant pleural mesothelioma response to chemotherapy [Poster presentation]. GIGA-Cancer Day, Liège, Belgium. * These authors have contributed equally to this work. |
Safari, R., Jacques, J.-R., Brostaux, Y., & Willems, L. (2020). Ablation of non-coding RNAs affects bovine leukemia virus B lymphocyte proliferation and abrogates oncogenesis. PLoS Pathogens, 16. doi:10.1371/journal.ppat.1008502 |
Sheynkman, G. M., Tuttle, K. S., Laval, F., Tseng, E., Underwood, J. G., Yu, L., Dong, D., Smith, M. L., Sebra, R., Willems, L., Hao, T., Calderwood, M. A., Hill, D. E., & Vidal, M. (2020). ORF Capture-Seq as a versatile method for targeted identification of full-length isoforms. Nature Communications, 11 (1). doi:10.1038/s41467-020-16174-z |
Hamaïdia, M., Gazon, H., Hoyos, C., Hoffmann, G. B., Louis, R., Duysinx, B., & Willems, L. (2019). Inhibition of EZH2 methyltransferase decreases immunoediting of mesothelioma cells by autologous macrophages through a PD-1-dependent mechanism. JCI Insight, 4 (18), 128474. doi:10.1172/jci.insight.128474 |
Gazon, H., Chauhan, P. S., Hamaïdia, M., Hoyos, C., Li, L., Safari, R., & Willems, L. (2018). How Does HTLV-1 Undergo Oncogene-Dependent Replication Despite a Strong Immune Response? Frontiers in Microbiology, 8, 2684. doi:10.3389/fmicb.2017.02684 |
Li, B., Leblois, J., Taminiau, B., Willems, L., Beckers, Y., Bindelle, J., & Everaert, N. (08 May 2017). The effect of inulin and/or wheat bran in the diet during early life on intestinal health of broiler chicks [Paper presentation]. 21st European Symposium on Poultry Nutrition (ESPN 2017). |
Hamaïdia, M., Barez, P.-Y., Carpentier, A., Lebecque, S., Miazek, K., Paul, A., Neelature Sriramareddy, S., Staumont, B., Danthine, S., Deleu, M., Frederich, M., De Pauw, E., Delaplace, P., Delvigne, F., Goffin, D., Ongena, M., Duysinx, B., Louis, R., cosse, J.-P., & Willems, L. (2016). From Valeriana officinalis to cancer therapy: the success of a bio-sourced compound. Biotechnologie, Agronomie, Société et Environnement, 20 (S1), 314-320. |
Miazek, K., Lebecque, S., Hamaïdia, M., Paul, A., Danthine, S., Willems, L., Frederich, M., De Pauw, E., Deleu, M., Richel, A., & Goffin, D. (2016). Sphingolipids: Promising lipid-class molecules with potential applications for industry. A review. Biotechnologie, Agronomie, Société et Environnement, 20 (S1), 321-336. |
Paul, A., Frederich, M., Uyttenbroeck, R., Hatt, S., Malik, P., Lebecque, S., Hamaïdia, M., Miazek, K., Goffin, D., Willems, L., Deleu, M., Fauconnier, M.-L., Richel, A., De Pauw, E., Blecker, C., Monty, A., Francis, F., Haubruge, E., & Danthine, S. (2016). Grasshoppers as a food source? A review. Biotechnologie, Agronomie, Société et Environnement, 20 (AgricultureIsLife), 337-352. |
Sainvitu, P., Nasir, M. N., Crowet, J.-M., Willems, L., Lins, L., & Deleu, M. (07 February 2014). Interactions between new phenolic glycolipids and model membrane [Poster presentation]. 19th NATIONAL SYMPOSIUM on APPLIED BIOLOGICAL SCIENCES, Gembloux, Belgium. |
Sainvitu, P., Nasir, M. N., Draguet, F., Nott, K., Lins, L., Crowet, J.-M., Willems, L., Cosse, J.-P., Jérôme, C., & Deleu, M. (30 May 2013). Novel phenolic glycolipids: antioxidant activity and effect on membrane models [Poster presentation]. Knowledge for Growth, Ghent, Belgium. |
Sainvitu, P., Nasir, M. N., Draguet, F., Nott, K., Lins, L., Crowet, J.-M., Willems, L., Cosse, J.-P., Jérôme, C., & Deleu, M. (15 May 2013). Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models [Poster presentation]. ICBCBBE 2013 : International Conference on Bioinformatics, Computational Biology and Biomedical Engineering, Amsterdam, Netherlands. |
Sainvitu, P., Nasir, M. N., Nott, K., Lins, L., Crowet, J.-M., Nicks, F., Laurent, P., Willems, L., Cosse, J.-P., Jérôme, C., & Deleu, M. (May 2013). Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models. World Academy of Science, Engineering and Technology, 77, 840. |
Sainvitu, P., Nasir, M. N., Nott, K., Lins, L., Crowet, J.-M., Willems, L., Cosse, J.-P., Jérôme, C., & Deleu, M. (May 2013). Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models. World Academy of Science, Engineering and Technology, 77, 840. |
Sainvitu, P., Nott, K., Nicks, F., Laurent, P., Willems, L., Cosse, J.-P., Crowet, J.-M., Lins, L., Jérôme, C., & Deleu, M. (16 November 2012). Synthesis and physico-chemical characterization of fatty esters [Poster presentation]. Journée scientifique SFM-BBM, Louvain-la-neuve, Belgium. |
Florins, A.-F., Reichert, M., Asquith, B., Bouzar, A., Jean, G., Francois, C., Jasik, A., Burny, A., Kettmann, R., & Willems, L. (2009). Earlier onset of delta-retrovirus-induced leukemia after splenectomy. PLoS ONE, 4 (9), 6943. doi:10.1371/journal.pone.0006943 |
Florins, A.-F., Gillet, N., Asquith, B., Boxus, M., Burteaux, C., Twizere, J.-C., Urbain, P., Vandermeers, F., Debacq, C., Sanchez-alcaraz, M. T., Schwartz-Cornil, I., Kerkhofs, P., Jean, G., Thewis, A., Hay, J., Mortreux, F., Wattel, E., Reichert, M., Burny, A., ... Willems, L. (2007). Cell dynamics and immune response to BLV infection: a unifying model. Frontiers in Bioscience: A Journal and Virtual Library, 12, 1520-1531. doi:10.2741/2165 |
Twizere, J.-C., Springael, J.-Y., Boxus, M., Burny, A., Dequiedt, F., Dewulf, J.-F., Duchateau, J., Portetelle, D., Urbain, P., Van Lint, C., Green, P. L., Mahieux, R., Parmentier, M., Willems, L., & Kettmann, R. (2007). Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling. Blood, 109 (3), 1051-60. doi:10.1182/blood-2006-06-026781 |
Debacq, C., Gillet, N., Asquith, B., Sanchez-Alcaraz, M. T., Florins, A.-F., Boxus, M., Schwartz-Cornil, I., Bonneau, M., Jean, G., Kerkhofs, P., Hay, J., Thewis, A., Kettmann, R., & Willems, L. (2006). Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep. Journal of Virology, 80 (19), 9710-9719. doi:10.1128/JVI.01022-06 |
Twizere, J.-C., Lefebvre, L., Collete, D., Debacq, C., Urbain, P., Heremans, H., Jauniaux, J.-C., Burny, A., Willems, L., & Kettmann, R. (2005). The homeobox protein MSX2 interacts with tax oncoproteins and represses their transactivation activity. Journal of Biological Chemistry, 280 (33), 29804-11. doi:10.1074/jbc.M503674200 |
Twizere, J.-C., Kruys, V., Lefebvre, L., Vanderplasschen, A., Collete, D., Debacq, C., Lai, W. S., Jauniaux, J.-C., Bernstein, L. R., Semmes, O. J., Burny, A., Blackshear, P. J., Kettmann, R., & Willems, L. (2003). Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression. Journal of the National Cancer Institute, 95 (24), 1846-59. doi:10.1093/jnci/djg118 |
Twizere, J.-C., Kerkhofs, P., Burny, A., Portetelle, D., Kettmann, R., & Willems, L. (2000). Discordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo. Journal of Virology, 74 (21), 9895-902. doi:10.1128/JVI.74.21.9895-9902.2000 |
Willems, L., Grimonpont, C., Kerkhofs, P., Capiau, C., Gheysen, D., Conrath, K., Roussef, R., Mamoun, R., Portetelle, D., Burny, A., Adam, E., Lefebvre, L., Twizere, J.-C., Heremans, H., & Kettmann, R. (1998). Phosphorylation of bovine leukemia virus Tax protein is required for in vitro transformation but not for transactivation. Oncogene, 16 (17), 2165-76. doi:10.1038/sj.onc.1201765 |
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