Publications and communications of Arnaud Blomme

Crake, R., Kiweler, N., Thiry, M., Peulen, O., Blomme, A., Meiser, J., Ambrogio, C., Santamaria, D., Cataldo, D., & Nokin, M.-J. (June 2023). Targeting metabolic adaptations in drug tolerant BRAFV600E mutant NSCLC [Poster presentation]. EACR 2023, Torino, Italy.

Largeot, A., Klapp, V., Viry, E., Gonder, S., Fernandez Botana, I., Blomme, A., Benzarti, M., Pierson, S., Duculty, C., Marttila, P., Wierz, M., Gargiulo, E., Pagano, G., An, N., El Hachem, N., Perez Hermandez, D., Chakraborty, S., Ysebaert, L., François, J.-H., ... Moussay, E. (2023). Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL. Blood. doi:10.1182/blood.2022017839

Almanza, A.* , Mnich, K.* , Blomme, A., Robinson, C. M., Rodriguez-Blanco, G., Kierszniowska, S., McGrath, E. P., Le Gallo, M., Pilalis, E., Swinnen, J. V., Chatziioannou, A., Chevet, E., Gorman, A. M., & Samali, A. (06 May 2022). Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer. Nature Communications, 13 (1), 2493. doi:10.1038/s41467-022-30159-0

Salji, M. J., Blomme, A., Däbritz, J. H. M., Repiscak, P., Lilla, S., Patel, R., Sumpton, D., van den Broek, N. J. F., Daly, R., Zanivan, S., & Leung, H. Y. (15 April 2022). Multi-omics & pathway analysis identify potential roles for tumor N-acetyl aspartate accumulation in murine models of castration-resistant prostate cancer. iScience, 25 (4), 104056. doi:10.1016/j.isci.2022.104056

Blomme, A., Peter, C., Mui, E., Rodriguez Blanco, G., An, N., Mason, L. M., Jamieson, L. E., McGregor, G. H., Lilla, S., Ntala, C., Patel, R., Thiry, M., Kung, S. H. Y., Leclercq, M., Ford, C. A., Rushworth, L. K., McGarry, D. J., Mason, S., Repiscak, P., ... Leung, H. Y. (2022). THEM6-mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer. EMBO Molecular Medicine, 14764. doi:10.15252/emmm.202114764

Martinez, R. S., Salji, M. J., Rushworth, L., Ntala, C., Rodriguez Blanco, G., Hedley, A., Clark, W., Peixoto, P., Hervouet, E., Renaude, E., Kung, S. H. Y., Galbraith, L. C. A., Nixon, C., Lilla, S., Mackay, G. M., Fazli, L., Gaughan, L., Sumpton, D., Gleave, M. E., ... Leung, H. Y.*. (2021). SLFN5 regulates LAT1-mediated mTOR activation in castration-resistant prostate cancer. Cancer Research. doi:10.1158/0008-5472.CAN-20-3694

Moncan, M., Mnich, K., Blomme, A., Almanza, A., Samali, A., & Gorman, A. M. (2021). Regulation of lipid metabolism by the unfolded protein response. Journal of Cellular and Molecular Medicine, 25 (3), 1359-1370. doi:10.1111/jcmm.16255

Ntala, C., Salji, M., Salmond, J., Officer, L., Teodosio, A. V., Blomme, A., McGhee, E. J., Powley, I., Ahmad, I., Kruithof-de Julio, M., Thalmann, G., Roberts, E., Goodyear, C. S., Jamaspishvili, T., Berman, D. M., Carlin, L. M., Le Quesne, J., & Leung, H. Y. (2021). Analysis of Prostate Cancer Tumor Microenvironment Identifies Reduced Stromal CD4 Effector T-cell Infiltration in Tumors with Pelvic Nodal Metastasis. European urology open science, 29, 19-29. doi:10.1016/j.euros.2021.05.001

Bellier, J., Nokin, M.-J., Caprasse, M., Tiamiou, A., Blomme, A., Scheijen, J. L., KOOPMANSCH, B., MacKay, G. M., Chiavarina, B., Costanza, B., Rademaker, G., Durieux, F., Agirman, F., Maloujahmoum, N., Cusumano, P. G., LOVINFOSSE, P., Leung, H. Y., LAMBERT, F., Bours, V., ... Bellahcene, A. (04 February 2020). Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab. Cell Reports, 30 (5), 1400-1416.e6. doi:10.1016/j.celrep.2020.01.012

Blomme, A., Ford, C. A., Mui, E., Patel, R., Ntala, C., Jamieson, L. E., Planque, M., McGregor, G. H., Peixoto, P., Hervouet, E., Nixon, C., Salji, M., Gaughan, L., Markert, E., Repiscak, P., Sumpton, D., Blanco, G. R., Lilla, S., Kamphorst, J. J., ... Leung, H. Y. (2020). 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer. Nature Communications, 11 (1), 2508. doi:10.1038/s41467-020-16126-7

Patel, R., Brzezinska, E. A., Repiscak, P., Ahmad, I., Mui, E., Gao, M., Blomme, A., Harle, V., Tan, E. H., Malviya, G., Mrowinska, A., Loveridge, C. J., Rushworth, L. K., Edwards, J., Ntala, C., Nixon, C., Hedley, A., Mackay, G., Tardito, S., ... Leung, H. Y. (2020). Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer. Cancer Research, 80 (3), 576-590. doi:10.1158/0008-5472.CAN-19-1684

Costanza, B., Rademaker, G., Tiamiou, A., De Tullio, P., Leenders, J., Blomme, A., Bellier, J., Bianchi, E., Turtoi, A., Delvenne, P., Bellahcene, A., Peulen, O.* , & Castronovo, V.*. (2019). TGFBI, an ECM interacting protein, enhances glycolysis and promotes pancreatic cancer cell migration. International Journal of Cancer. doi:10.1002/ijc.32247

Costanza, B., Turtoi, A., Bellahcene, A., Hirano, T., Peulen, O., Blomme, A., Hennequiere, J., MUTIJIMA NZARAMBA, E., Boniver, J., Meuwis, M.-A., JOSSE, C., KOOPMANSCH, B., SEGERS, K., Yokobori, T., Fahmy, K., Thiry, M., COIMBRA MARQUES, C., Garbacki, N., Colige, A., ... Castronovo, V. (2018). Innovative methodology for the identification of soluble biomarkers in fresh tissues. Oncotarget, 9 (12), 10665-10680. doi:10.18632/oncotarget.24366

Patel, R., Fleming, J., Mui, E., Loveridge, C., Repiscak, P., Blomme, A., Harle, V., Salji, M., Ahmad, I., Teo, K., Hamdy, F. C., Hedley, A., van den Broek, N., Mackay, G., Edwards, J., Sansom, O. J., & Leung, H. Y. (2018). Sprouty2 loss-induced IL6 drives castration-resistant prostate cancer through scavenger receptor B1. EMBO Molecular Medicine, 10 (4). doi:10.15252/emmm.201708347

Hendrick, E., Peixoto, P., Blomme, A., Polese, C., Matheus, N., Cimino, J., Frère, A., Mouithys-Mickalad, A., Serteyn, D., Bettendorff, L., Elmoualij, B., De Tullio, P., Eppe, G., Dequiedt, F., Castronovo, V., & Mottet, D. (2017). Metabolic inhibitors accentuate the anti-tumoral effect of HDAC5 inhibition. Oncogene. doi:10.1038/onc.2017.103

Nokin, M.-J., Durieux, F., Peixoto, P., Chiavarina, B., Peulen, O., Blomme, A., Turtoi, A., Costanza, B., Smargiasso, N., Baiwir, D., Scheijen, J., Schalkwijk, C., Leenders, J., De Tullio, P., BIANCHI, E., Thiry, M., Uchida, K., Spiegel, D., Cochrane, J., ... Bellahcene, A. (2016). Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP- mediated tumor growth and metastasis. eLife. doi:10.7554/eLife.19375

Blomme, A., Cusumano, P., Peulen, O., Bellahcene, A., Castronovo, V., & Turtoi, A. (2016). L'asporine : une nouvelle defense naturelle contre le cancer du sein. MS. Medecine Sciences, 32 (11), 1019-1022. doi:10.1051/medsci/20163211020

Costanza, B., Blomme, A., Bellahcene, A., Peulen, O., MUTIJIMA NZARAMBA, E., DELVENNE, P., De Pauw, E., DETRY, O., COIMBRA MARQUES, C., Castronovo, V., & Turtoi, A. (2016). EXPEL: A Novel Non-Destructive Method for Mining Soluble Tumor Biomarkers. Acta Gastro-Enterologica Belgica, 79 (1), 11.

Costanza, B., Blomme, A., MUTIJIMA NZARAMBA, E., DELVENNE, P., DETRY, O., Castronovo, V., & Turtoi, A. (March 2015). Expel: a novel non-destructive method for mining soluble tumor biomarkers. Acta Gastro-Enterologica Belgica, 78 (1), 13.

Perez Palacios, A., Blomme, A., Boutry, S., Doumont, G., Sherer, F., Van Simaeys, G., Debois, D., JERUSALEM, G., COLLIGNON, J., DELVENNE, P., DETRY, O., De Pauw, E., Muller, R., Goldman, S., Castronovo, V., & Turtoi, A. (March 2015). Metabolomic, proteomic and preclinical imaging of patient-derived tumor xenografts for improving treatment of liver metastases patients. Acta Gastro-Enterologica Belgica, 78 (1), 134.

Blomme, A., Costanza, B., Thiry, M., De Tullio, P., Perez-Palacios, A., Mouithys-Mickalad, A., LIFRANGE, E., Delvenne, P., Castronovo, V., & Turtoi, A. (31 January 2015). Myoferlin Regulates Endosomal Trafficking and Tunes Cancer Cell Metabolism [Poster presentation]. ASSOCIATION BELGE POUR L'ETUDE DU CANCER "A.B.E.C» ANNUAL MEETING 2015: TUMOR METABOLISM AND MITOCHONDRIA, Louvain, Belgium.

Blomme, A., Costanza, B., Thiry, M., De Tullio, P., Perez Palacios, A., LIFRANGE, E., DELVENNE, P., Castronovo, V., & Turtoi, A. (27 January 2015). Myoferlin regulates endosomal trafficking and tunes cancer cell metabolism [Poster presentation]. GIGA-DAY 2015: Current advances in medical genetics and genomics, Liège, Belgium.

Costanza, B., Blomme, A., Bellahcene, A., MUTIJIMA NZARAMBA, E., Peulen, O., & DELVENNE, P. (January 2015). EXPEL: A Novel Non-Destructive Method for Mining Soluble Tumor Biomarkers [Poster presentation]. Belgian Association Cancer Research.

Maris, P., Blomme, A., Palacios, A. P., Costanza, B., Bellahcene, A., BIANCHI, E., GOFFLOT, S., Drion, P., Trombino, G. E., Di Valentin, E., CUSUMANO, G., MAWEJA, S., JERUSALEM, G., Delvenne, P., LIFRANGE, E., Castronovo, V., & Turtoi, A. (2015). Asporin Is a Fibroblast-Derived TGF-beta1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer. PLoS Medicine, 12 (9), 1001871. doi:10.1371/journal.pmed.1001871

Turtoi, A., Blomme, A., & Castronovo, V. (2015). Intratumoral heterogeneity and consequences for targeted therapies. Bulletin du Cancer, 102 (1), 17-23. doi:10.1016/j.bulcan.2014.12.006

Blomme, A. (2014). Contribution towards understanding the role of Myoferlin during breast cancer progression [Doctoral thesis, Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/314799

Castronovo, V., Blomme, A., Delvenne, P., DETRY, O., & Turtoi, A. (March 2014). TGF-B induced protein IG-H3 is essential for the growth of human liver metastases. Acta Gastro-Enterologica Belgica, 77 (1), 05.

Turtoi, A., Blomme, A., Debois, D., SOMJA, J., De Pauw, E., DETRY, O., & Castronovo, V. (March 2014). Organized proteomic heterogeneity in colorectal liver metastases and implications for therapies. Acta Gastro-Enterologica Belgica, 77 (1), 07.

Costanza, B., Blomme, A., Bellahcene, A., Hennequière, V., LIFRANGE, E., DELVENNE, P., Castronovo, V., & Turtoi, A. (2014). Myoferlin is a Key Regulator of HER Receptor Family Function in Breast Cancer [Paper presentation]. EDT Annual Mini symposium 2014.

Turtoi, A.* , Blomme, A.* , BIANCHI, E., Maris, P., Vannozzi, R., Naccarato, A. G., DELVENNE, P., De Pauw, E., Bevilacqua, G., & Castronovo, V. (2014). Accessibilome of human glioblastoma: collagen-VI-alpha-1 is a new target and a marker of poor outcome. Journal of Proteome Research, 13 (12), 5660-5669. doi:10.1021/pr500657w

Turtoi, A.* , Blomme, A.* , Bellahcene, A., Gilles, C., Hennequière, V., Peixoto, P., BIANCHI, E., Noël, A., De Pauw, E., LIFRANGE, E., Delvenne, P., & Castronovo, V. (2013). Myoferlin is a key regulator of EGFR activity in breast cancer. Cancer Research, 73, 5438-5448. doi:10.1158/0008-5472.CAN-13-1142

Warnock, G., Turtoi, A., Blomme, A., Gonzalez, A., Bretin, F., Bahri, M. A., Lemaire, C., Seret, A., Castronovo, V., Luxen, A., & Plenevaux, A. (October 2012). In Ovo PET Imaging Of A Human Colorectal Carcinoma Model In Chicken Chorioallantoic Membrane [Poster presentation]. Annual Congress of the European Association of Nuclear Imaging, Milan, Italy.

Turtoi, A., Blomme, A., Delvaux, D., Dumont, B., SOMJA, J., Debois, D., DELVENNE, P., De Pauw, E., DE ROOVER, A., Honoré, P., DETRY, O., & Castronovo, V. (May 2012). INTRA-TUMORAL HETEROGENEITY AND RATIONAL SELECTION OF ANTIGENS FOR TARGETED THERAPY OF LIVER METASTASES. Acta Chirurgica Belgica, 112 (3), 89.FP53.

Castronovo, V., Blomme, A., Dumont, B., & Turtoi, A. (2011). Development of Targeted Therapies for Liver Metastases: Is Heterogeneity a Major Issue? [Paper presentation]. Annual Meeting at Experimental Biology, Washington DC, United States.