Publications and communications of Michael Herfs

Pilard, C., RONCARATI, P., Ancion, M., Luyckx, M., Renard, M., Reynders, C., Lerho, T., Poulain, F., Bruyère, D., LEBEAU, A., Hendrick, E., Crake, R., Peiffer, R., Nokin, M.-J., Peulen, O., Delvenne, P., Hubert, P.* , & Herfs, M.*. (13 March 2025). RANKL blockade inhibits cancer growth through reversing the tolerogenic profile of tumor-infiltrating (plasmacytoid) dendritic cells. Journal for ImmunoTherapy of Cancer, 13 (3), 010753. doi:10.1136/jitc-2024-010753

Overs, A., Peixoto, P., Hervouet, E., Molimard, C., Monnien, F., Durand, J., Guittaut, M., Vienot, A., Viot, J., Herfs, M., Borg, C., Feugeas, J.-P., & Selmani, Z. (18 October 2024). COL25A1 and METAP1D DNA methylation are promising liquid biopsy epigenetic biomarkers of colorectal cancer using digital PCR. Clinical Epigenetics, 16 (1), 146. doi:10.1186/s13148-024-01748-1

Nokin, M.-J., Darbo, E., Richard, E., San José, S., de Hita, S., Prouzet-Mauleon, Turcs, B., Gerardelli, L., Crake, R., Velasco, V., KOOPMANSCH, B., Lambert, F., Xue, J. Y., Sang, B., Horne, J., Ziemons, E., Villanueva, A., Blomme, A., Herfs, M., ... Santamaria, D. (2024). In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma. Cell Reports Medicine. doi:10.1016/j.xcrm.2024.101663

El Hachem, N., Leclercq, M., Susaeta Ruiz, M., Vanleyssem, R., Shostak, K., Körner, P.-R., Capron, C., Martin Morales, L., RONCARATI, P., Lavergne, A., Blomme, A., Turchetto, S., Goffin, E., Thandapani, P., Tarassov, I., Nguyen, L., Pirotte, B., Chariot, A., Marine, J.-C., ... Close, P. (2024). Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma. Nature Cell Biology. doi:10.1038/s41556-024-01439-2

Mourtada, J., Lony, C., Nicol, A., De Azevedo, J., Bour, C., Macabre, C., RONCARATI, P., Ledrappier, S., Schultz, P., Borel, C., Burgy, M., Wasylyk, B., Mellitzer, G., Herfs, M., Gaiddon, C., & Jung, A. C. (October 2023). A novel ΔNp63-dependent immune mechanism improves prognosis of HPV-related head and neck cancer. Frontiers in Immunology, 14, 1264093. doi:10.3389/fimmu.2023.1264093

Ancion, M., Luyckx, M., Renard, M., Reynders, C., Lerho, T., Bruyère, D., Hendrick, E., Pilard, C., RONCARATI, P., Herfs, M., & Hubert, P. (12 June 2023). Approach using "second generation" immune checkpoint inhibitors for the treatment of triple-negative breast cancer [Poster presentation]. EACR 2023, Turin, Italy.

Rademaker, G., Costanza, B., Bellier, J., Herfs, M., Peiffer, R., Agirman, F., Maloujahmoum, N., Habraken, Y., Delvenne, P., Bellahcene, A., Castronovo, V., & Peulen, O. (02 March 2023). Correction: Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis. Oncogenesis, 12 (1), 11. doi:10.1038/s41389-023-00455-5

Reynders, C., RONCARATI, P., Ancion, M., Lerho, T., Luyckx, M., Renard, M., Delvenne, P., Hubert, P., & Herfs, M. (02 February 2023). Histopathological characterization of esophageal tumors and potential involvement of high-risk HPV in carcinogenesis [Poster presentation]. Séminaire des chercheurs Télévie 2023.

Bruyere, D., RONCARATI, P., Lebeau, A., Lerho, T., Poulain, F., Hendrick, E., Pilard, C., Reynders, C., Ancion, M., Luyckx, M., Renard, M., Jacob, Y., Twizere, J.-C., Peiffer, R., Peulen, O., Delvenne, P., Hubert, P., McBride, A., Gillet, N., ... Herfs, M. (2023). Human papillomavirus E6/E7 oncoproteins promote radiotherapy-mediated tumor suppression by globally hijacking host DNA damage repair. Theranostics, 13 (3), 1130 - 1149. doi:10.7150/thno.78091

Gallego, C., Jaracz-Ros, A., Laganà, M., Mercier-Nomé, F., Domenichini, S., Fumagalli, A., Roingeard, P., Herfs, M., Pidoux, G., Bachelerie, F., & Schlecht-Louf, G. (2023). Reprogramming of connexin landscape fosters fast gap junction intercellular communication in human papillomavirus-infected epithelia. Frontiers in Cellular and Infection Microbiology, 13, 1138232. doi:10.3389/fcimb.2023.1138232

Mouziane, L., Crake, R., Maloujahmoum, N., Agirman, F., Roncarati, P., Herfs, M., & Bellahcene, A. (30 September 2022). Characterisation of methylglyoxal stress in human colorectal cancer and liver metastases using immunohistochemistry [Poster presentation]. BACR, Gent, Belgium.

Reynders, C., Roncarati, P., Ancion, M., Lerho, T., Bruyère, D., Delvenne, P., Hubert, P., & Herfs, M. (29 September 2022). Caractérisations histopathologiques des cancers œsophagiennes et potentiel implication des infections par HPV de haut-risques [Paper presentation]. Conférence annuelle de l'Association Francophone pour l'étude des Infections à Papillomavirus et Polyomavirus 2022, France.

Reynders, C., RONCARATI, P., Ancion, M., Lerho, T., Pilard, C., Bruyère, D., Hendrick, E., Delvenne, P., Hubert, P., & Herfs, M. (09 September 2022). Histopathological characterization of esophageal tumors and potential involvement of high-risk HPV in carcinogenesis [Poster presentation]. INTERUNIVERSITY PHD STUDENT DAY.

Reynders, C., RONCARATI, P., Ancion, M., Lerho, T., Pilard, C., Hendrick, E., Bruyère, D., Delvenne, P., Hubert, P., & Herfs, M. (06 September 2022). Histopathological characterization of esophageal tumors and potential involvement of high-risk HPV infections in carcinogenesis [Poster presentation]. GIGA-Day 2022.

Reynders, C., RONCARATI, P., Ancion, M., Lerho, T., Hendrick, E., Bruyère, D., Pilard, C., Delvenne, P., Hubert, P., & Herfs, M. (08 April 2022). Histopathological characterization of esophageal cancers and potential role of high-risk HPV infections [Poster presentation]. Séminaire des chercheurs Télévie 2022, Belgium.

Lebeau, A.* , Bruyère, D.* , RONCARATI, P., Peixoto, P., Hervouet, E., COBRAIVILLE, G., Taminiau, B., Masson, M., Gallego, C., Mazzucchelli, G., Smargiasso, N., Fleron, M., Baiwir, D., Hendrick, E., Pilard, C., Lerho, T., Reynders, C., Ancion, M., GREIMERS, R., ... Herfs, M. (28 February 2022). HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources. Nature Communications, 13 (1), 1076. doi:10.1038/s41467-022-28724-8

Debernardi, A., Meurisse, A., Prétet, J.-L., Guenat, D., Monnien, F., Spehner, L., Vienot, A., RONCARATI, P., André, T., Abramowitz, L., Molimard, C., Mougin, C., Herfs, M., Kim, S., & Borg, C. (2022). Prognostic role of HPV integration status and molecular profile in advanced anal carcinoma: An ancillary study to the epitopes-HPV02 trial. Frontiers in Oncology, 12, 941676. doi:10.3389/fonc.2022.941676

Reynders, C., RONCARATI, P., Ancion, M., Lerho, T., Pilard, C., Bruyère, D., Hendrick, E., Delvenne, P., Hubert, P., & Herfs, M. (14 December 2021). Histopathological characterization of esophageal cancers and potential role of high-risk HPV infections [Poster presentation]. Giga Cancer Day 2021.

Reynders, C., RONCARATI, P., Ancion, M., Lerho, T., Bruyère, D., Hendrick, E., Pilard, C., Hubert, P., Delvenne, P., & Herfs, M. (01 October 2021). Caractérisation histopathologique des cancers œsophagiens et potentiel rôle des HPV [Paper presentation]. Conférence annuelle de l'Association Francophone pour l'étude des Infections à Papillomavirus et Polyomavirus, France.

Baudu, T., Parratte, Perez, V., Ancion, M., Millevoi, S., Hervouet, E., Peigney, A., Peixoto, P., Overs, A., Herfs, M., Fraichard, A., Guittaut, M., & Baguet, A. (2021). The NMD Pathway Regulates GABARAPL1 mRNA during the EMT. Biomedicines. doi:10.3390/biomedicines9101302

Hubert, P., RONCARATI, P., Demoulin, S., Pilard, C., Ancion, M., Reynders, C., Lerho, T., Bruyère, D., Lebeau, A., Radermecker, C., Meunier, M., Nokin, M.-J., Hendrick, E., Peulen, O., Delvenne, P., & Herfs, M. (2021). Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy. Journal for ImmunoTherapy of Cancer, 9 ((3)), 001966. doi:10.1136/jitc-2020-001966

Kerselidou, D., Dohai, B. S., Nelson, D. R., Daakour, S., De Cock, N., Hassoun, Z. E. O., Kim, D.-K., Olivet, J., El Assal, D. C., Jaiswal, A., Alzahmi, A., Saha, D., Pain, C., Matthijssens, F., Lemaitre, P., Herfs, M., Chapuis, J., Ghesquiere, B., Vertommen, D., ... Twizere, J.-C. (2021). Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells. Science Advances, 7 (19). doi:10.1126/sciadv.abe8349

Pilard, C., RONCARATI, P., Hendrick, E., Lebeau, A., Bruyère, D., Lerho, T., Ancion, M., Reynders, C., DELVENNE, P., Herfs, M., & Hubert, P. (01 October 2020). P08.03 Combining PD-1/PD-L1 blockade and RANKL inhibitors to treat breast cancers unresponsive to standard therapy. Journal for ImmunoTherapy of Cancer, 8 (Suppl 2), 50-A51. doi:10.1136/jitc-2020-ITOC7.99

Lachat, C., Bruyère, D., Etcheverry, A., Aubry, M., Mosser, J., Warda, W., Herfs, M., Hendrick, E., Ferrand, C., Borg, C., Delage-Mourroux, R., Feugeas, J.-P., Guittaut, M., Hervouet, E., & Peixoto, P. (2020). EZH2 and KDM6B Expressions Are Associated with Specific Epigenetic Signatures during EMT in Non Small Cell Lung Carcinomas. Cancers, 12, 3649-3671. doi:10.3390/cancers12123649

Rademaker, G., Costanza, B., Bellier, J., Herfs, M., Agirman, F., Maloujahmoum, N., Bellahcene, A., Castronovo, V., & Peulen, O. (26 November 2019). Myoferlin depletion induces DNA damage response and p53- dependent cell cycle arrest and apoptosis in colon cancer [Poster presentation]. Metabolism in Cancer and Stromal Cells (2nd edition), Leuven, Belgium.

Dewez, F., Martin-Lorenzo, M., Herfs, M., Baiwir, D., Mazzucchelli, G., De Pauw, E., Heeren, R. M. A., & Balluff, B. (14 June 2019). Precise co-registration of mass spectrometry imaging, histology, and laser microdissection-based omics. Analytical and Bioanalytical Chemistry, 411, 5647-5653. doi:10.1007/s00216-019-01983-z

Nokin, M.-J., Bellier, J., Durieux, F., Peulen, O., Rademaker, G., Gabriel, M., Monseur, C., CHARLOTEAUX, B., Verbeke, L., van Laere, S., RONCARATI, P., Herfs, M., Lambert, C., Scheijen, J., Schalkwijk, C., Colige, A., Caers, J., Delvenne, P., Turtoi, A., ... Bellahcene, A. (2019). Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer. Breast Cancer Research, 21(1, 11. doi:10.1186/s13058-018-1095-7

Paget-Bailly, P., Meznad, K., Bruyère, D., Perrard, J., Herfs, M., Jung, A., Mougin, C., Pretet, J.-L., & Baguet, A. (2019). Comparative RNA sequencing reveals that HPV16 E6 abrogates the effect of E6*I on ROS metabolism. Scientific Reports, 11, 5938. doi:10.1038/s41598-019-42393-6

Peixoto, P., Etcheverry, A., Aubry, M., Missey, A., Lachat, C., Perrard, J., Hendrick, E., Delage-Mourroux, R., Mosser, J., Borg, C., Feugeas, J.-P., Herfs, M., Boyer-Guittaut, M., & Hervouet, E. (2019). EMT is associated with an epigenetic signature of ECM remodeling genes. Cell Death and Disease, 10 (3), 205. doi:10.1038/s41419-019-1397-4

Rademaker, G., Costanza, B., Bellier, J., Herfs, M., Peiffer, R., Agirman, F., Maloujahmoum, N., Habraken, Y., Delvenne, P., Bellahcene, A., Castronovo, V.* , & Peulen, O.*. (2019). Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis. Oncogenesis. doi:10.1038/s41389-019-0130-6

Claude-Taupin, A., Fonderflick, L., Gauthier, T., Mansi, L., Pallandre, J.-R., Borg, C., Perez, V., Monnien, F., Algros, M.-P., Vigneron, M., Adami, P., Delage-Mourroux, R., Peixoto, P., Herfs, M., Boyer-Guittaut, M., & Hervouet, E. (December 2018). ATG9A Is Overexpressed in Triple Negative Breast Cancer and Its In Vitro Extinction Leads to the Inhibition of Pro-Cancer Phenotypes. Cells, 7(12). doi:10.3390/cells7120248

Bruyère, D., Lebeau, A., RONCARATI, P., Hendrick, E., Masson, M., Twizere, J.-C., Pilard, C., Hubert, P., DELVENNE, P., & Herfs, M. (28 May 2018). Deciphering the radiosensitivity of HPV-positive tumors [Poster presentation]. EDT-Immunology day 2018, Liège, Belgium.

Rademaker, G., Hennequière, V., Nokin, M.-J., LOVINFOSSE, P., Durieux, F., GOFFLOT, S., Bellier, J., Costanza, B., Herfs, M., Peiffer, R., Bettendorff, L., Deroanne, C., Thiry, M., Delvenne, P., Hustinx, R., Bellahcene, A., Castronovo, V., & Peulen, O. (April 2018). Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness. Oncogene, 37 ((32)), 4398-4412. doi:10.1038/s41388-018-0287-z

Herfs, M., Soong, T. R., Delvenne, P., & Crum, C. (April 2017). Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis. Viruses, 9 (4), 85. doi:10.3390/v9040085

Howitt, B., Herfs, M., Tomoka, T., Kamiza, S., Gheit, T., Tommasino, M., Delvenne, P., Crum, C., & Milner, D. (August 2016). Comprehensive Human Papilloma Virus (HPV) Genotyping in Cervical Squamous Cell Carcinomas and its Relevance to Cervical Cancer Prevention in Malawian Women. Journal of Global Oncology, 3, 227-234.

Suarez-Carmona, M., Hubert, P., Gonzalez, A., Duray, A., RONCARATI, P., Erpicum, C., Boniver, J., Castronovo, V., Noël, A., Saussez, S., Peulen, O., Delvenne, P., & Herfs, M. (2014). DeltaNp63 isoform-mediated beta-defensin family up-regulation is associated with (lymph)angiogenesis and poor prognosis in patients with squamous cell carcinoma. Oncotarget, 5 (7), 1856-1868. doi:10.18632/oncotarget.1819

Herfs, M., Hubert, P., Kholod, N., Caberg, J.-H., Gilles, C., Berx, G., Savagner, P., Boniver, J., & Delvenne, P. (May 2008). Transforming growth factor-beta1-mediated Slug and Snail transcription factor up-regulation reduces the density of Langerhans cells in epithelial metaplasia by affecting E-cadherin expression. American Journal of Pathology, 172 (5), 1391-402. doi:10.2353/ajpath.2008.071004

Delvenne, P., Goffin, F., Kridelka, F., Arafa, M., Carberg, J., Herfs, M., Herman, L., Hubert, P., Jacobs, N., Kholod, N., Foidart, J.-M., & Boniver, J. (2007). La cancer du col utérin: une infection par HPV qui tourne mal. Tempo Médical.

Delvenne, P., Goffin, F., Kridelka, F., Arafa, M., Caberg, J.-H., Herfs, M., Herman, L., Hubert, P., Jacobs, N., Kholod, N., Boniver, J., & Foidart, J.-M. (2007). Le cancer du col de l'utérus: du virus au traitement. Revue Médicale de Liège, 62(S1), 2-6.

Delvenne, P., Herman, L., Kholod, N., Caberg, J.-H., Herfs, M., Boniver, J., Jacobs, N., & Hubert, P. (2007). Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix. Molecular and Cellular Endocrinology, 264 (1-2), 1-5. doi:10.1016/j.mce.2006.10.014