Penoy, N., Avohou, T. H., Lebrun, P., Evrard, B., & Piel, G. (11 December 2019). A quality by design approach for liposomes production by innovative method using supercritical fluids: which parameters use to obtain good physicochemical characteristics? [Paper presentation]. Second CIRM Scientific Day, Liège, Belgium. |
Hubert, C., Lebrun, P., Boulanger, B., & Hubert, P. (11 May 2017). Cycle de vie des méthodes, vers une maîtrise intégrée des performances quantitatives [Paper presentation]. AFSEP - Comment garantir un résultat quantitatif ?, Lyon, France. |
Habyalimana, V., Mbinze Kindenge, J., Yemoa, L., Waffo Tchounga, C., Diallo, T., Kalenda Tshilombo, N., Kadima Ntokamunda, J.-L., Lebrun, P., Hubert, P., & Marini Djang'Eing'A, R. (18 October 2016). APPLICATION OF DESIGN SPACE OPTIMIZATION STRATEGY TO THE DEVELOPMENT OF LC METHODS FOR SIMULTANEOUS ANALYSIS OF 18 ANTIRETROVIRAL MEDICINES AND 4 MAJOR EXCIPIENTS USED IN VARIOUS PHARMACEUTICAL FORMULATIONS [Paper presentation]. 19th Forum of Pharmaceutical Sciences / BELGIAN SOCIETY OF PHARMACEUTICAL SCIENCES, Brussels, Belgium. |
Hubert, C., Houari, S., Rozet, E., Lebrun, P., & Hubert, P. (2015). Towards a full integration of optimization and validation phases: An Analytical-Quality-by-Design approach. Journal of Chromatography. A. doi:10.1016/j.chroma.2015.03.059 |
Lebrun, P., Giacoletti, K., Scherder, T., Rozet, E., & Boulanger, B. (2015). A quality by design approach for longitudinal quality attributes. Journal of Biopharmaceutical Statistics, 25, 1-13. doi:10.1080/10543406.2014.979197 |
Rozet, E., Lebrun, P., Michiels, J.-F., Sondag, P., Scherder, T., & Boulanger, B. (2015). Analytical Procedure Validation and the Quality by Design Paradigm. Journal of Biopharmaceutical Statistics, 25, 1-9. doi:10.1080/10543406.2014.971176 |
Dispas, A., Lebrun, P., & Hubert, P. (June 2014). Quantitative performances of UHPSFC and UHPLC : a comparative study [Paper presentation]. Drug Analysis 2014, Liège, Belgium. |
Habyalimana, V., Kalenda Tshilombo, N., Dispas, A., Andri, B., Loconon Yemoa, A., Kindenge Mbinze, J., Kadima Ntokamunda, J., Lebrun, P., Hubert, P., & Marini Djang'Eing'A, R. (June 2014). MULTI-TRANSFER OF GENERIC ANALYTICAL METHODS TO COMBAT POOR QUALITY ANTIMALARIAL MEDICINES: A LABORATORY BASED APPROACH TO SUPPORT DRUG QA/QC SYSTEMS [Poster presentation]. DRUG ANALYSIS 2014: 10th International Symposium on Drug Analysis & 25th International Symposium on Pharmaceutical and Biomedical Analysis. |
Sacre, P.-Y., Lebrun, P., Chavez, P.-F., De Bleye, C., Netchacovitch, L., Rozet, E., Klinkenberg, R., Streel, B., Hubert, P., & Ziemons, E. (2014). A new criterion to assess distributional homogeneity in hyperspectral images of solid pharmaceutical dosage forms. Analytica Chimica Acta, 818, 7-14. doi:10.1016/j.aca.2014.02.014 |
Dispas, A., Lebrun, P., & Hubert, P. (October 2013). Robust SFC method optimization using design space strategy [Paper presentation]. 17e Forum des Sciences Pharmaceutiques, Spa, Belgium. |
Dispas, A., Mbinze Kindenge, J., Lebrun, P., Kalenda, N., Habyalimana, V., Rozet, E., Marini Djang'Eing'A, R., & Hubert, P. (July 2013). ANALYTICAL DESIGN SPACE STRATEGY FOR THE DEVELOPMENT OF LC METHODS TO COMBAT POTENTIALLY COUNTERFEIT ANTIBIOTIC DRUGS [Paper presentation]. 24th International Symposium on Pharmaceutical and Biomedical Analysis, Bologne, Italy. |
Lebrun, P., Boulanger, B., Debrus, B., Lambert, P., & Hubert, P. (2013). A Bayesian Design Space for analytical methods based on multivariate models and predictions. Journal of Biopharmaceutical Statistics, 23, 1330–1351. doi:10.1080/10543406.2013.834922 |
Dispas, A., Lebrun, P., Sassiat, P., Thiébaut, D., Vial, J., & Hubert, P. (October 2012). Innovative green supercritical fluid chromatography development for the separation of neurotransmitters using design space strategy [Paper presentation]. SFC2012, Bruxelles, Belgium. |
Lebrun, P. (2012). Bayesian Design Space applied to Pharmaceutical Development [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/126503 |
Mbinze Kindenge, J., Lebrun, P., Debrus, B., Dispas, A., Hubert, C., Rozet, E., Marini Djang'Eing'A, R., & Hubert, P. (June 2012). APPLICATION OF AN INNOVATIVE DESIGN SPACE OPTIMIZATION STRATEGY TO THE DEVELOPMENT OF LC METHODS TO COMBAT POTENTIALLY COUNTERFEIT NSAIDS [Poster presentation]. HPLC 2012, Anaheim, California, United States. |
Ziemons, E., De Bleye, C., Chavez, P.-F., Rozet, E., Lebrun, P., & Hubert, P. (10 May 2012). Development of near infrared spectroscopic methods using desirability indexes: How to select the most appropriate calibration model [Paper presentation]. EuPAT 5 - Fith pan-European QbD & PAT Science Conference, Ghent, Belgium. |
Mbinze Kindenge, J., Lebrun, P., Debrus, B., Dispas, A., Hubert, P., & Marini Djang'Eing'A, R. (May 2012). THE DEVELOPMENT OF LC GENERIC ANALYTICAL METHODS TO FIGHT COUNTERFEIT NSAIDS USING DESIGN SPACE OPTIMISATION STRATEGY [Paper presentation]. 16ème FORUM DES SCIENCES PHARMACEUTIQUES, Blankenberge, Belgium. |
Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Klinkerberg, R., Streel, B., Evrard, B., & Hubert, P. (March 2012). AN INNOVATIVE APPROACH TO SELECT THE PREDICTION MODEL IN THE DEVELOPMENT OF NIR SPECTROSCOPIC METHODS [Poster presentation]. AGROSTAT 2012, Paris, France. |
Rozet, E., Debrus, B., Lebrun, P., Boulanger, B., & Hubert, P. (February 2012). COMBINATION OF INDEPENDENT COMPONENT ANALYSIS, DESIGN OF EXPERIMENTS AND DESIGN SPACE FOR A NOVEL METHODOLOGY TO DEVELOP CHROMATOGRAPHIC METHODS [Poster presentation]. 12th International Symposium on Hyphenated Techniques for Chromatography (HTC-12), Bruges, Belgium. |
Dispas, A., Lebrun, P., Mbinze Kindenge, J., Debrus, B., Mavar Tayer Mbay, J., Boulanger, B., Marini Djang'Eing'A, R., & Hubert, P. (December 2011). Application d'une nouvelle méthode de développement de méthodes chromatographiques pour lutter contre la contrefaçon des médicaments anti-inflammatoires [Paper presentation]. Chimiométrie 2011, Marseille, France. |
Boulanger, B., Lebrun, P., Rozet, E., & Hubert, P. (29 November 2011). Design Space ou Espace de Conception [Paper presentation]. Liège Creative, Liege, Belgium. |
Rozet, E., Debrus, B., Lebrun, P., Boulanger, B., & Hubert, P. (08 September 2011). New Methodology for the Development of Chromatographic Methods [Paper presentation]. 17th International Symposium on Separation Sciences – ISSS 2011, Cluj, Romania. |
Marini Djang'Eing'A, R., Mbinze Kindenge, J., Debrus, B., Lebrun, P., Mantanus, J., Ziemons, E., Lamalle, C., Fillet, M., Rudaz, S., & Hubert, P. (September 2011). IMPLEMENTATION OF GENERIC ANALYTICAL METHODS TO FIGHT AGAINST COUNTERFEIT MEDICINES [Paper presentation]. Recent Development in Pharmaceutical Analysis (RDPA), Pavia, Italy. |
Rozet, E., Marini Djang'Eing'A, R., Lebrun, P., Ziemons, E., Boulanger, B., & Hubert, P. (September 2011). A BAYESIAN PREDICTIVE PROBABILITY CRITERION TO ASSESS ANALYTICAL METHODS VALIDITY [Poster presentation]. Recent Development in Pharmaceutical Analysis (RDPA), Pavia, Italy. |
Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Klinkenberg, R., Streel, B., Moonen, F., Evrard, B., & Hubert, P. (08 December 2010). Vibrational spectroscopy in pharmaceutical industry: From development of the most appropriate predictive model to routine implementation [Poster presentation]. BioWin Day 2010, Louvain-la-Neuve, Belgium. |
Rozet, E., Lebrun, P., Boulanger, B., Ziemons, E., & Hubert, P. (02 December 2010). Evaluating analytical results reliability using a Bayesian probability criterion [Poster presentation]. Congrès Chimimétrie 2010, Paris, France. |
Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Klinkenberg, R., Streel, B., Evrard, B., Moonen, F., & Hubert, P. (02 December 2010). Use of tolerance intervals in the development of near infrared spectroscopic methods: An innovative way to select the most appropriate calibration model [Poster presentation]. Chimiométrie 2010, Paris, France. |
Lebrun, P., Lambert, P., Debrus, B., Hubert, P., Marini Djang'Eing'A, R., Moonen, F., & Boulanger, B. (December 2010). Developing and optimizing analytical chromatographic method in a Quality by Design environment. Bayesian multi-criteria risk-based Design Space to guarantee future quality [Poster presentation]. Chimiométrie 2010, Paris, France. |
Krier, F., Brion, M., Debrus, B., Lebrun, P., Driesen, A., Ziemons, E., Evrard, B., & Hubert, P. (15 November 2010). Optimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities [Poster presentation]. The FIP Pharmaceutical Sciences World Congress 2010 in association with the AAPS Annual Meeting & Exposition, new orléans, United States. |
Mantanus, J., Lebrun, P., Rozet, E., Evrard, B., Hubert, P., & Ziemons, E. (14 October 2010). La spectroscopie proche infrarouge et Raman: Nouvelles armes vertes dans le contrôle de la qualité du médicament [Poster presentation]. Journée Scientifique Annuelle de la Société Royale de Chimie: Chimie Verte, Gembloux, Belgium. |
Hubert, P., Ziemons, E., Mantanus, J., Lebrun, P., Boulanger, B., & Rozet, E. (October 2010). RISK MANAGMENT IN THE VALIDATION OF ANALYTICAL METHODS [Paper presentation]. CNFR 2010 Congress, Targu-Mures, Romania. |
Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Cao, M., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (September 2010). Application of experimental design and design for the separation of compounds extracted from the leaves of Strychnos Usambarensis [Poster presentation]. Drug analysis 2010, Antwerpen, Belgium. |
Nistor, I., Lecomte, F., Mbinze Kindenge, J., Debrus, B., Lebrun, P., Marini Djang'Eing'A, R., Oprean, R., & Hubert, P. (September 2010). Transfer of a conventional LC method for the screening of conterfeit antimalarial medicines to UHPLC [Poster presentation]. Drug analysis 2010, Antwerpen, Belgium. |
Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Klinkenberg, R., Streel, B., Evrard, B., & Hubert, P. (September 2010). An innovative approach to select the prediction model in the development of NIR spectroscopy methods [Poster presentation]. Drug Analysis, Antwerpen, Belgium. |
Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Martine, C., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (26 January 2010). Optimisation de la séparation des alcaloïdes extraits des feuilles de Strychnos usambarensis au moyen du design space [Paper presentation]. Assemblée générale du CIRM et forum des jeunes chercheurs, Liège, Belgium. |
Mbinze Kindenge, J., Marini Djang'Eing'A, R., Debrus, B., Lebrun, P., Lecomte, F., Boulanger, B., & Hubert, P. (December 2009). Développement d’une méthode pour la séparation de 19 antipaludéens par HPLC au moyen de la planification expérimentale et du Design Space [Poster presentation]. 7ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages (SEP'09), Marseille, France. |
Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Cao, M., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (December 2009). Application de la planification expérimentale et du design space pour la séparation des composés extraits des feuilles de Strychnos usambarensis [Poster presentation]. 7ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages (SEP'09), Marseille, France. |
Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Klinkenberg, R., Streel, B., & Hubert, P. (November 2009). Active content determination of non-coated pharmaceutical pellets by near infrared spectroscopy: Method development, validation and reliability evaluation [Poster presentation]. Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists, Los Angeles, United States. |
Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Rudaz, S., Klinkenberg, R., Streel, B., & Hubert, P. (September 2009). Validation of a near infrared spectroscopy method for the quantitative determination of an active ingredient in non-coated pharmaceutical pellets [Poster presentation]. 13th International Meeting of Recent Developments in Pharmaceutical Analysis, Milan, Italy. |
De Backer, B., Debrus, B., Lebrun, P., Dubois, N., Hubert, P., & Charlier, C. (August 2009). Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoïds in cannabis plant material [Poster presentation]. 47ème meeting de l'International Association of Forensic Toxicologists (TIAFT), Genève, Switzerland. |
Nistor, I., Debrus, B., Lebrun, P., Rozet, E., Ceccato, A., Caliaro, G., Oprean, R., Boulanger, B., & Hubert, P. (27 April 2009). Nouvelle méthodologie pour le développement automatisé de méthodes analytiques en chromatographie liquide pour l'analyse de mélanges de composés inconnus [Paper presentation]. Assemblée générale du CIRM et forum des jeunes chercheurs, Liège, Belgium. |
Debrus, B., Lebrun, P., Rozet, E., Nistor, I., Ceccato, A., Caliaro, G., Oprean, R., Boulanger, B., & Hubert, P. (2009). Nouvelle méthodologie pour le développement automatisé de méthodes analytiques en chromatographie liquide pour l’analyse de mélanges de composés inconnus. Spectra Analyse, 268, 28-33. |
Ziemons, E., Bourichi, H., Mantanus, J., Lebrun, P., Bouklouze, A., Cherrah, Y., & Hubert, P. (October 2008). Analyse quantitative de mélanges binaires de deux formes cristallines du fluconazole par la spectroscopie proche infrarouge et par diffraction des rayons X: comparaison des deux méthodes [Paper presentation]. 2ème Congrès des Sciences Analytiques, Casablanca, Morocco. |
Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Rozet, E., Rupérez, J., Barbas, C., Boulanger, B., & Hubert, P. (July 2008). Chromatographic separation of a pharmaceutical formulation using Design of Experiment and Design Space [Poster presentation]. 11th conference on Chemometrics in Analytical Chemistry (CAC'2008), Montpellier, France. |
Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Jupérez, J., Barbas, C., Boulanger, B., & Hubert, P. (June 2008). Usefulness of design space for the optimization of chromatographic separations [Paper presentation]. 19th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2008), Gdansk, Poland. |
Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Klinkenberg, R., Streel, B., Evrard, B., & Hubert, P. (2008). Determination of moisture content in pharmaceutical pellets using near infrared spectroscopy: Method development and validation [Paper presentation]. PAT Workshop, Gent, Belgium. |
Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Klinkenberg, R., Streel, B., & Hubert, P. (2008). Moisture content determination of pharmaceutical pellets by near infrared spectroscopy: model selection, evaluation and validation [Poster presentation]. 11th Conference on Chemometrics in Analytical Chemistry, Montpellier, France. |
Ziemons, E., Mantanus, J., Lebrun, P., Rozet, E., & Hubert, P. (2008). Reflexions, La Chimie Analytique Verte. (Planet'ULg, ULiège - Université de Liège). Reflexions. |
Lebrun, P., Debrus, B., Boulanger, B., Caliaro, G., Ceccato, A., & Hubert, P. (June 2007). Numerical separation in HPLC-UV-DAD with Independent Component Analysis (ICA) using high order statistics for the automated identification of peaks [Poster presentation]. HPLC 2007, Gent, Belgium. |
Debrus, B., Lebrun, P., Boulanger, B., Dewé, W., Ceccato, A., & Hubert, P. (20 March 2007). Séparation numérique et quantification automatique de pics en CLHP-UV grâce à l’utilisation de l’analyse en composantes indépendantes (ICA) [Paper presentation]. SEP 2007, Grenoble, France. |
Debrus, B., Lebrun, P., Boulanger, B., Dewé, W., Ceccato, A., & Hubert, P. (20 March 2007). Evaluation d'une nouvelle méthode pour le développement entièrement automatisé de méthodes analytiques en chromatographie liquide [Poster presentation]. SEP 2007, Grenoble, France. |
Boulanger, B., Dewé, W., Ceccato, A., Debrus, B., Lebrun, P., & Hubert, P. (December 2006). Utilisation de l’Analyse en Composantes Indépendantes (ICA) pour la séparation numérique des pics et la quantification automatique en CLHP-UV [Paper presentation]. Chimiométrie 2006, Paris, France. |
Lebrun, P., Boulanger, B., Hubert, P., Debrus, B., & Govaerts, B. (December 2006). Statistical Models and Multi-Criteria Optimization Techniques in Chromatography [Paper presentation]. Chimiométrie 2006, Paris, France. |