Publications and communications of Gilles Darcis

Buanec, H. L., Schiavon, V., Merandet, M., How-Kit, A., Bergerat, D., Fombellida-Lopez, C., Bensussan, A., Bouaziz, J.-D., Burny, A., Darcis, G., Song, H., Sajadi, M. M., Kottilil, S., Gallo, R. C., & Zagury, D. (19 March 2024). Early elevated IFNα is a key mediator of HIV pathogenesis. Communications Medicine, 4 (1), 53. doi:10.1038/s43856-024-00454-6

Le Buanec, H., Schiavon, V., Merandet, M., How-Kit, A., Song, H., Bergerat, D., Fombellida-Lopez, C., Bensussan, A., Bouaziz, J.-D., Burny, A., Darcis, G., Sajadi, M. M., Kottilil, S., Zagury, D., & Gallo, R. C. (19 March 2024). IFNα induces CCR5 in CD4+ T cells of HIV patients causing pathogenic elevation. Communications Medicine, 4 (1), 52. doi:10.1038/s43856-024-00453-7

Scaia, D., Fombellida, K., Maes, N., El Moussaoui, M., & Darcis, G. (14 March 2024). Risk Factors for Late HIV Presentation in Patients Treated at a Single Belgian Reference Centre from 2018 to 2022. Infectious Disease Reports, 16 (2), 239 - 248. doi:10.3390/idr16020019

Fombellida-Lopez, C., Berkhout, B., Darcis, G., & Pasternak, A. O. (2024). Persistent HIV-1 transcription during ART: time to reassess its significance? Current Opinion in HIV and AIDS. doi:10.1097/COH.0000000000000849

El Moussaoui, M., Bontems, S., Meex, C., Hayette, M.-P., LEJEUNE, M., Hong, S. L., Dellicour, S., Moutschen, M., CAMBISANO, N., Renotte, N., Bours, V., Darcis, G., Artesi, M.* , & Durkin, K.*. (2024). Intrahost evolution leading to distinct lineages in the upper and lower respiratory tracts during SARS-CoV-2 prolonged infection. medRxiv preprint. doi:10.1101/2024.03.03.24303157
* These authors have contributed equally to this work.

Laverdeur, J., Desmecht, D., Hayette, M.-P., & Darcis, G. (15 January 2024). Dengue and chikungunya: future threats for Northern Europe? Frontiers in Epidemiology, 4. doi:10.3389/fepid.2024.1342723

Callewaert, C., Pezavant, M., Vandaele, R., Meeus, B., Vankrunkelsven, E., Van Goethem, P., Plumacker, A., Misset, B., Darcis, G., PIRET, S., De Vleeschouwer, L., Staelens, F., Van Varenbergh, K., Tombeur, S., Ottevaere, A., Montag, I., Vandecandelaere, P., Jonckheere, S., Vandekerckhove, L., ... Guyot, H. (19 September 2023). Sniffing out safety: canine detection and identification of SARS-CoV-2 infection from armpit sweat. Frontiers in Medicine, 10. doi:10.3389/fmed.2023.1185779

Vossius, G., Meex, C., Moerman, F., THYS, M., Ernst, M., Bourgeois, M.-E., Wagner, L., DELAHAYE, T., & Darcis, G. (11 September 2023). Clinical Outcomes of Third-Generation Cephalosporin Definitive Therapy for Bloodstream Infections Due to Enterobacterales with Potential AmpC Induction: A Single-Center Retrospective Study. Pathogens (Basel, Switzerland), 12 (9), 1152. doi:10.3390/pathogens12091152

COVID-19 Host Genetics Initiative, Rahmouni, S., Georges, M., Moutschen, M., Darcis, G., & Beguin, Y. (September 2023). A second update on mapping the human genetic architecture of COVID-19. Nature, 621 (7977), 7 - E26. doi:10.1038/s41586-023-06355-3

Llucià-Carol, L., Elena Muiño, Natalia Cullell, Jara Cárcel-Márquez, Miquel Lledós, Cristina Gallego-Fabrega, Jesús Martin-Campos, Joan Martí-Fàbregas, Ana Aguilera-Simón, Anna M. Planas, Marta L. DeDiego, Alicia de Felipe Mimbrera, Jaime Masjuan, Sebastián García-Madrona, Tomás Segura, Esther González-Villar, Gemma Serrano-Heras, Ana Domínguez Mayoral, Paloma Menéndez-Valladares, ... Israel Fernández-Cadenas. (30 August 2023). Genetic Architecture of Ischaemic Strokes after COVID-19 Shows Similarities with Large Vessel Strokes. International Journal of Molecular Sciences, 24 (17). doi:10.3390/ijms241713452

Lambert, N., El Moussaoui, M., Baron, F., Maquet, P., & Darcis, G. (06 July 2023). Virus-Specific T-Cell Therapy for Viral Infections of the Central Nervous System: A Review. Viruses, 15 (7), 1510. doi:10.3390/v15071510

Kremer, C., Torneri, A., Libin, P. J. K., Meex, C., Hayette, M.-P., Bontems, S., Durkin, K. W., Artesi, M., Bours, V., Lemey, P., Darcis, G., Hens, N., & Meuris, C. (16 June 2023). Reconstruction of SARS-CoV-2 outbreaks in a primary school using epidemiological and genomic data. Epidemics, 44, 100701. doi:10.1016/j.epidem.2023.100701

Le Buanec, H., Schiavon, V., Merandet, M., How-Kit, A., Bergerat, D., Fombellida-Lopez, C., Bensussan, A., Bouaziz, J.-D., Burny, A., Darcis, G., Song, H., Sajadi, M. M., Kottilil, S., Gallo, R. C., & Zagury, D. (2023). Early Elevated IFNα Identified as the Key Mediator of HIV Pathogenesis and its low level a Hallmark of Elite Controllers. ORBi-University of Liège. doi:10.21203/

Le Buanec, H., Schiavon, V., Merandet, M., How-Kit, A., Song, H., Bergerat, D., Fombellida-Lopez, C., Bensussan, A., Bouaziz, J.-D., Burny, A., Darcis, G., Sajadi, M. M., Kottilil, S., Zagury, D., & Gallo, R. C. (2023). IFNα induces CCR5 in CD4+ T-cells, causing its anti- HIV inefficiency and its subsequent pathogenic elevation, partially controlled by anti-HIV therapy. ORBi-University of Liège. doi:10.21203/

El Moussaoui, M., Guiot, J., FRIPPIAT, F., & Darcis, G. (May 2023). Une cause émergente de fatigue et de douleurs chroniques : l’affection post-COVID-19 ou COVID long. Revue Médicale de Liège, 78 (5-6), 299 - 304.

Nasreddine, R., Florence, E., Yombi, J. C., Henrard, S., Darcis, G., Van Praet, J., Vandekerckhove, L., Allard, S. D., Demeester, R., Messiaen, P., Ausselet, N., Delforge, M., De Wit, S., & Belgian Research on AIDS and HIV Consortium (BREACH). (2023). Efficacy, durability, and tolerability of bictegravir/emtricitabine/tenofovir alafenamide for the treatment of HIV in a real-world setting in Belgium. HIV Medicine. doi:10.1111/hiv.13493

de Crane D'Heysselaer, S., Parisi, G., Lisson, M., Bruyère, O., Donneau, A.-F., Fontaine, S., Gillet, L., Bureau, F., Darcis, G., Thiry, E., Ducatez, M., Snoeck, C. J., Zientara, S., Haddad, N., Humblet, M.-F., Ludwig-Begall, L., Daube, G., Thiry, D., Misset, B., ... Haubruge, E. (27 February 2023). Systematic Review of the Key Factors Influencing the Indoor Airborne Spread of SARS-CoV-2. Pathogens, 12 (3), 382. doi:10.3390/pathogens12030382

Meuris, C., Darcis, G., Orban, C., Hayette, M.-P., Meex, C., Desmecht, D., & Bours, V. (2023). Study of asymptomatic rectal carriage of Monkeypox virus in men who have sex with men, and immunological answer to vaccination, followed in Liège University Hospital.

El Moussaoui, M., Desmecht, S., Lambert, N., Maes, N., Braghini, J., MARECHAL, N., Quintana, C., BRIQUET, K., Gofflot, S., Toussaint, F., Hayette, M.-P., Vermeersch, P., Lutteri, L., GREGOIRE, C., Beguin, Y., Rahmouni, S., Moutschen, M., Desmecht, D., & Darcis, G. (2023). Cluster Analysis Identifies Distinct Patterns of T-Cell and Humoral Immune Responses Evolution Following a Third Dose of SARS-CoV-2 Vaccine in People Living with HIV. Viruses, 15, 1435. doi:10.3390/v15071435

Mayasi Ngongo, N., Kamangu Ntambwe, E., Situakibanza Nani-Tuma, H., Mbula Mambimbi, M., Mandina Ndona, M., Longokolo Mashi, M., Bepouka Izizag, B., Lukiana, T., Odio Ossam, J., Mangala Sonzi, D., Maes, N., Moutschen, M., El Moussaoui, M., & Darcis, G. (2023). Human Immunodeficiency Virus Viral Load Monitoring and Rate of Virologic Suppression Among Patients Receiving Antiretroviral Therapy in Democratic Republic of the Congo, 2013-2020. Open Forum Infectious Diseases, 10 (6), 2-7. doi:10.1093/ofid/ofad242

El Moussaoui, M., Desmecht, S., Tashkeev, A., Lambert, N., Maes, N., Braghini, J., MARECHAL, N., Quintana, C., BRIQUET, K., Gofflot, S., TOUSSAINT, F., Hayette, M.-P., Vermeersch, P., Lutteri, L., Grégoire, C., Beguin, Y., Rahmouni, S., Moutschen, M., Desmecht, D., & Darcis, G. (05 September 2022). Reduced T-cell response following a third dose of SARS-CoV-2 vaccine in infection-naïve people living with HIV. Journal of Infection, 85, 751-755. doi:10.1016/j.jinf.2022.09.006

Pathak, G. A., Karjalainen, J., Stevens, C., Neale, B. M., Daly, M., Ganna, A., Andrews, S. J., Kanai, M., Cordioli, M., Polimanti, R., Harerimana, N., Pirinen, M., Liao, R. G., Chwialkowska, K., Trankiem, A., Balaconis, M. K., Nguyen, H., Solomonson, M., Veerapen, K., ... Baillie, J. K. (03 August 2022). A first update on mapping the human genetic architecture of COVID-19. Nature, 608, 1-E10. doi:10.1038/s41586-022-04826-7

Cruz, R., Almeida, S. D.-D., Heredia, M. L., Quintela, I., Ceballos, F. C., Pita, G., Lorenzo-Salazar, J. M., González-Montelongo, R., Gago-Domínguez, M., Porras, M. S., Castaño, J. A. T., Nevado, J., Aguado, J. M., Aguilar, C., Aguilera-Albesa, S., Almadana, V., Almoguera, B., Alvarez, N., Andreu-Bernabeu, Á., ... Carracedo, Á. (2022). Novel genes and sex differences in COVID-19 severity. Human Molecular Genetics. doi:10.1093/hmg/ddac132

El Moussaoui, M., Maes, N., Hong, S. L., Lambert, N., Gofflot, S., DELLOT, P., Belhadj, Y., Huynen, P., Hayette, M.-P., Meex, C., Bontems, S., Defêche, J., Godderis, L., Molenberghs, G., Meuris, C., Artesi, M., Durkin, K., Rahmouni, S., GREGOIRE, C., ... DARCIS, G. (14 June 2022). Evaluation of Screening Program and Phylogenetic Analysis of SARS-CoV-2 Infections among Hospital Healthcare Workers in Liège, Belgium. Viruses, 14 (6), 1302. doi:10.3390/v14061302

Mayasi, N., Situakibanza, H., Mbula, M., Longokolo, M., Maes, N., Bepouka, B., Ossam, J. O., MOUTSCHEN, M., & DARCIS, G. (11 March 2022). Retention in care and predictors of attrition among HIV-infected patients who started antiretroviral therapy in Kinshasa, DRC, before and after the implementation of the ‘treat-all’ strategy. PLOS Global Public Health, 2 (3), 0000259. doi:10.1371/journal.pgph.0000259

Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., Russell, C. D., Malinauskas, T., Wu, Y., Millar, J., Shen, X., Elliott, K. S., Griffiths, F., Oosthuyzen, W., Morrice, K., Keating, S., Wang, B., Rhodes, D., Klaric, L., ... LAMBERMONT, B. (Other coll.). (2022). Whole-genome sequencing reveals host factors underlying critical COVID-19. Nature. doi:10.1038/s41586-022-04576-6

Cambier, M., Henket, M., Frix, A.-N., Gofflot, S., THYS, M., Tomasetti, S., Peired, A., Struman, I., Rousseau, A.-F., Misset, B., Darcis, G., Moutschen, M., Louis, R., Njock, M.-S., Cavalier, E., & Guiot, J. (2022). Increased KL-6 levels in moderate to severe COVID-19 infection. PLoS ONE, 17 (11), 0273107. doi:10.1371/journal.pone.0273107

Desmecht, S.* , Tashkeev, A.* , El Moussaoui, M., MARECHAL, N., Perée, H., Tokunaga, Y., Fombellida-Lopez, C., Polese, B., Legrand, C., Wéry, M., Mni, M., Fouillien, N., TOUSSAINT, F., Gillet, L., Bureau, F., LUTTERI, L., HAYETTE, M.-P., MOUTSCHEN, M., MEURIS, C., ... DARCIS, G.*. (2022). Kinetics and persistence of the cellular and humoral immune responses to BNT162b2 mRNA vaccine in SARS-CoV-2-naive and -experienced subjects: impact of booster dose and breakthrough infections. Frontiers in Immunology, 13, 863554. doi:10.3389/fimmu.2022.863554
* These authors have contributed equally to this work.

Donneau, A.-F.* , Guillaume, M.* , BOURS, V., Dandoy, M., DARCIS, G., Desmecht, D., Diep, A. N., Fievez, L., Garigliany, M.-M., Gillain, N., Husson, E., Michel, F., MOUTSCHEN, M., Paridans, M., Pétré, B., Sabatel, C., Saegerman, C., Tytgat, A., Gillet, L.* , & Bureau, F.*. (2022). University population-based prospective cohort study of SARS-CoV- 2 infection and immunity (SARSSURV-ULiège): a study protocol. BMJ Open. doi:10.1136/bmjopen-2021-055721
* These authors have contributed equally to this work.

Van Beckhoven, D., Serrien, B., Montourcy, M., Verhofstede, C., Van den Bossche, D., Libois, A., De Geyter, D., Martin, T., Van den Eynde, S., Vuylsteke, B., Darcis, G., van Halem, K., Florence, E., Deblonde, J., Ausselet, N. (Other coll.), Delforge, M.-L. (Other coll.), Demeester, R. (Other coll.), De Munter, P. (Other coll.), Goffard, J.-C. (Other coll.), ... Yombi, J.-C. (Other coll.). (2022). Impact of COVID-19 on the Belgian HIV epidemic: slowdown of HIV transmission and testing and adaptation of care. BMC Infectious Diseases, 22 (1), 901. doi:10.1186/s12879-022-07879-1

Nakanishi, T., Pigazzini, S., Degenhardt, F., Cordioli, M., Butler-Laporte, G., Maya-Miles, D., Nafría-Jiménez, B., Bouysran, Y., Niemi, M., Palom, A., Ellinghaus, D., Khan, A., Martínez-Bueno, M., Rolker, S., Amitano, S., Tato, L. R., Fava, F., Spinner, C. D., Prati, D., ... consortium, C.-H. (October 2021). Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality. Journal of Clinical Investigation, Online ahead of print.. doi:10.1172/JCI152386

BOUQUEGNEAU, A., HUART, J., LUTTERI, L., ERPICUM, P., GROSCH, S., Résimont, G., WIESEN, P., ROUSSEAU, A.-F., BOVY, C., KRZESINSKI, J.-M., THYS, M., LAMBERMONT, B., Misset, B., Pottel, H., DARCIS, G., CAVALIER, E., JOURET, F., & DELANAYE, P. (2021). Survivors of COVID-19 mostly recover from tubular proteinuria and acute kidney injury after hospital discharge. Journal of Nephrology, 34 (4), 967-969. doi:10.1007/s40620-021-01075-1

Meuris, C., Kremer, C., Geerinck, A., Locquet, M., Bruyère, O., Defêche, J., Meex, C., Hayette, M.-P., Duchene, L., Dellot, P., Azarzar, S., Maréchal, N., Sauvage, A.-S., Frippiat, F., Giot, J.-B., Léonard, P., Fombellida, K., Moutschen, M., Durkin, K., ... Darcis, G. (2021). Transmission of SARS-CoV-2 After COVID-19 Screening and Mitigation Measures for Primary School Children Attending School in Liège, Belgium. JAMA Network Open, 4 (10), 2128757. doi:10.1001/jamanetworkopen.2021.28757

Ngongo, N. M., Darcis, G., Nanituna, H. S., Mambimbi, M. M., Maes, N., Mashi, M. L., Bepouka Izizag, B., Moutschen, M., & Lepira Bompeka, F. (2021). Longitudinal analysis of sociodemographic, clinical and therapeutic factors of HIV-infected individuals in Kinshasa at antiretroviral therapy initiation during 2006-2017. PLoS ONE, 16 (11), 0259073. doi:10.1371/journal.pone.0259073

Niemi, M., Gazon, H., JUSZCZAK, D., FADEUR, M., CAMBY, S., MEURIS, C., THYS, M., JACQUES, J., HENKET, M., BEGUIN, Y., Rahmouni, S., Lebrun, M., MOUTSCHEN, M., Misset, B., DARCIS, G., GUIOT, J., AZARZAR, S., DELLOT, P., GOFFLOT, S., ... HUYNEN, P. (Other coll.). (2021). Mapping the human genetic architecture of COVID-19. Nature, 600, 472-477. doi:10.1038/s41586-021-03767-x

Plum, P.-E., Darcis, G., & Moutschen, M. (2021). L’arrivée des bithérapies dans le traitement du virus de l’immunodéficience humaine : la fin d’un dogme? Revue Médicale de Liège, 76 (9), 677 - 682.

Ait-Ammar, A., Kula, A., DARCIS, G., Verdikt, R., De wit, S., Gautier, V., Mallon, P., Marcello, A., Rohr, O., & Van Lint, C. (2020). Current Status of Latency Reversing Agents Facing the Heterogeneity of HIV-1 Cellular and Tissue Reservoirs. Frontiers in Microbiology. doi:10.3389/fmicb.2019.03060

Darcis, G., Berkhout, B., & Pasternak, A. O. (2020). Differences in HIV Markers between Infected Individuals Treated with Different ART Regimens: Implications for the Persistence of Viral Reservoirs. Viruses, 12 (5). doi:10.3390/v12050489

Darcis, G., Kootstra, N. A., Hooibrink, B., van Montfort, T., Maurer, I., Groen, K., Jurriaans, S., Bakker, M., van Lint, C., Berkhout, B., & Pasternak, A. O. (2020). CD32+CD4+ T Cells Are Highly Enriched for HIV DNA and Can Support Transcriptional Latency. Cell Reports, 30 (7), 2284-2296.e3. doi:10.1016/j.celrep.2020.01.071

DARCIS, G., VAIRA, D., & MOUTSCHEN, M. (2020). Impact of coronavirus pandemic and containment measures on HIV diagnosis. Epidemiology and Infection. doi:10.1017/S0950268820001867

Cimpaye, O., Louis, R., Darcis, G., Beaudart, C., & MEURIS, C. (2019). Evaluation de l'application des recommandations du Conseil Supérieur de la Santé relatives à l'isolement respiratoire des malades atteints de la tuberculose pulmonaire au CHU de Liège. Revue Médicale de Liège, 74 (9), 465-470.

DARCIS, G., Binda, C., Klaver, B., Herrera-Carrillo, E., Berkhout, B., & Das, A. (2019). The Impact of HIV-1 Genetic Diversity on CRISPR-Cas9 Antiviral Activity and Viral Escape. Viruses. doi:10.3390/v11030255

Van Montfort, T., Van der sluis, R., DARCIS, G., Beaty, D., Groen, K., Pasternak, A., Pollakis, G., Vink, M., Westerhout, E., Hamdi, M., Bakker, M., Van Der Putten, B., Jurriaans, S., Prins, J., Jeeninga, R., Thomas, A., Speijer, D., & Berkhout, B. (2019). Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway. EBioMedicine. doi:10.1016/j.ebiom.2019.02.014

DARCIS, G., Lambert, I., SAUVAGE, A.-S., FRIPPIAT, F., MEURIS, C., UURLINGS, F., LECOMTE, M., LEONARD, P., GIOT, J.-B., fombellida, K., VAIRA, D., & MOUTSCHEN, M. (2018). Factors associated with late presentation for HIV care in a single Belgian reference center: 2006-2017. Scientific Reports. doi:10.1038/s41598-018-26852-0

DARCIS, G., Das, A. T., & Berkhout, B. (2018). Tackling HIV Persistence: Pharmacological versus CRISPR-Based Shock Strategies. Viruses. doi:10.3390/v10040157

DE VOEGHT, A., Martens, H., RENARD, J. D. C., VAIRA, D., Debruche, M., Simonet, J., Geenen, V., MOUTSCHEN, M., & DARCIS, G. (2017). Exploring the link between innate immune activation and thymic function by measuring sCD14 and TRECs in HIV patients living in Belgium. PLoS ONE. doi:10.1371/journal.pone.0185761

DARCIS, G., Van der Auwera, G., GIOT, J.-B., Hayette, M.-P., Tassin, F., Arrese Estrada, J., Cnops, L., Moutschen, M., de Leval, L., & LEONARD, P. (07 July 2017). Recurrence of visceral and muco-cutaneous leishmaniasis in a patient under immunosuppressive therapy. BMC Infectious Diseases, 17. doi:10.1186/s12879-017-2571-x

Bouchat, S., Delacourt, N., Kula, A., DARCIS, G., Van Driessche, B., Corazza, F., GATOT, J.-S., Melard, A., Vanhulle, C., Kabeya, K., Pardons, M., Avettand-Fenoel, V., Clumeck, N., De Wit, S., Rohr, O., Rouzioux, C., & Van Lint, C. (2016). Sequential treatment with 5-aza-2'-deoxycytidine and deacetylase inhibitors reactivates HIV-1. EMBO Molecular Medicine. doi:10.15252/emmm.201505557

DARCIS, G., Coombs, R. W., & Van Lint, C. (2016). Exploring the anatomical HIV reservoirs: Role of the testicular tissue. AIDS, 30 (18), 2891-2893. doi:10.1097/QAD.0000000000001281

DARCIS, G., Kula, A., Bouchat, S., Fujinaga, K., Corazza, F., Ait-Ammar, A., Delacourt, N., Melard, A., Kabeya, K., Vanhulle, C., Van Driessche, B., GATOT, J.-S., Cherrier, T., Pianowski, L. F., Gama, L., Schwartz, C., Vila, J., Burny, A., Clumeck, N., ... Van Lint, C. (2015). An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression. PLoS Pathogens, 11 (7), 1005063. doi:10.1371/journal.ppat.1005063