Publications and communications of Eric Goffin

Colson, T., Piette, M., Bay, Y., Pickering, D. S., Kristensen, A. S., Baudino, G., Tchekounang Tchonwa, I. F., Pochet, L., Goffin, E., Lesenfants, C., Kastrup, J. S., Pirotte, B., & Francotte, P. (31 January 2024). Advances in Targeting Kainic Acid Receptors: Developing Selective Positive Allosteric Modulators from the 1,2,4-Benzothiadiazine 1,1-Dioxide scaffold [Poster presentation]. CIRM Day 2024, Liège, Belgium.

Lesenfants, C., Goffin, E., Colson, T., Chaaya, N., Leroy, C., Garigliany, M.-M., Chavatte, P., Reboud-Ravaux, M., Pirotte, B., El Amri, C., & Francotte, P. (31 January 2024). RATIONAL DESIGN OF COUMARIN DERIVATIVES WITH A BASIC MOIETY FOR INHIBITING THE SERINE PROTEASE TMPRSS2: AN INNOVATIVE APPROACH TO COMBAT THE ENTRY OF SELECTED RESPIRATORY VIRUSES [Poster presentation]. CIRM Day, Liège, Belgium.

Francotte, P., Bay, Y., Goffin, E., Colson, T., Lesenfants, C., Dorosz, J., Laulumaa, S., Fraikin, P., De Tullio, P., Beaufour, C., Botez, I., Pickering, D., Frydenvang, K., Danober, L., Skov Kristensen, A., Sandholm Kastrup, J., & Pirotte, B. (09 December 2023). Exploring thienothiadiazine dioxides as isosteric analogues of benzo-and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. European Journal of Medicinal Chemistry, 264, 116036. doi:10.1016/j.ejmech.2023.116036

Colson, T., Piette, M., Bay, Y., Pickering, D. S., Kristensen, A. S., Baudino, G., Tchekounang Tchonwa, I. F., Leroy, C., Pochet, L., Goffin, E., Lesenfants, C., & Kastrup, J. S. (08 December 2023). Kainic Acid Receptors: Innovating Selective Positive Allosteric Modulators based on 1,2,4-Benzothiadiazine 1,1-Dioxides [Poster presentation]. MedChem 2023, Bruxelles, Belgium.

Lesenfants, C., Leroy, C., Goffin, E., Colson, T., Chaaya, N., Garigliany, M.-M., Chavatte, P., Reboud-Ravaux, M., Pirotte, B., El Amri, C., & Francotte, P. (08 December 2023). EXPLORING COUMARIN DERIVATIVES AS NOVEL ANTIVIRAL AGENTS TARGETING TMPRSS2: A MULTIDISCIPLINARY APPROACH FOR RESPIRATORY VIRAL DISEASE TREATMENT [Poster presentation]. MedChem 2023, Bruxelles, Belgium.

Colson, T., Piette, M., Bay, Y., Pickering, D. S., Kristensen, A. S., Goffin, E., Lesenfants, C., Kastrup, J. S., Pirotte, B., & Francotte, P. (19 October 2023). Glutamate Regulation: Synthesis of Selective Positive Allosteric Modulators of the Kainic Acid Receptors belonging to 1,2,4-Benzothiadiazine 1,1-Dioxides [Poster presentation]. SRC 2023 Scientific Day, Louvain-La-Neuve, Belgium.

Lesenfants, C., Leroy, C., Goffin, E., Colson, T., Garigliany, M.-M., Chavatte, P., Reboud, M., Pirotte, B., El Amri, C., & Francotte, P. (19 October 2023). Design of original serine protease inhibitors to combat viral respiratory infections: a synthetic pathway for new coumarinic compounds [Poster presentation]. 2023 SRC Scientific Day, Louvain-la-Neuve, Belgium.

Oury, C., Meyers, S., Jacques, N., Leeten, K., Jiang, Z., MUSUMECI, L., Lox, M., Debuisson, M., Goffin, E., Pirotte, B., Delvenne, P., Nchimi Longang, A., Hubert, C., Heptia, M., Hubert, P., Kuijpers, M. J. E., Vanassche, T., Martinod, K., Verhamme, P., & Lancellotti, P. (2023). Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice. JACC: Basic to Translational Science. doi:10.1016/j.jacbts.2023.02.003

Goffin, E., Fraikin, P., Abboud, D., De Tullio, P., Beaufour, C., Botez, I., Hanson, J., Danober, L., Francotte, P., & Pirotte, B. (15 March 2023). New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring. European Journal of Medicinal Chemistry, 250, 115221. doi:10.1016/j.ejmech.2023.115221

Lesenfants, C., Goffin, E., Pirotte, B., Dammicco, S., & Francotte, P. (02 February 2022). Contribution to the synthesis of positive allosteric modulators of AMPA receptors for potential use in the early diagnosis of neurodegenerative diseases [Poster presentation]. CIRM Day, Liège, Belgium.

Pirotte, B., Florence, X., Goffin, E., Leleux, F., & Lebrun, P. (2022). Research Advancements on Fluorinated and Non-Fluorinated 4- Phenyl(thio)ureido-Substituted 2,2-Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants. Medicinal chemistry (Shariqah (United Arab Emirates)), 18 (8), 884-894. doi:10.2174/1573406418666220221145500

LANCELLOTTI, P., Oury, C., Pirotte, B., MUSUMECI, L., Jacques, N., & Goffin, E. (23 September 2021). Preparation of pyrimidine derivatives for prevention and treatment of Gram-negative bacterial infection, contamination and fouling.

Oury, C., Pirotte, B., MUSUMECI, L., Jacques, N., Goffin, E., & LANCELLOTTI, P. (22 October 2020). New pyrimidine derivatives for prevention and treatment of gram negative bacterial infection, contamination and fouling.

Stiti, M. Z., Belghobsi, M., Habila, T., Goffin, E., De Tullio, P., Pirotte, B., Faury, G., & Khelili, S. (March 2020). Synthesis and vasodilator activity of new 1,4-dihyropyridines bearing sulfonylurea, urea and thiourea moieties. Chemical Papers, 74 (3), 915 - 928. doi:10.1007/s11696-019-00925-4

Conlon, T., John-Schuster, G., Heide, D., Pfister, D., Lehmann, M., Hu, Y., Ertuz, Z., Lopez, M., Ansari, M., Strunz, M., Mayr, C., Cimineiri, C., Costa, R., Kohlhepp, M. S., Guillot, A., Günes, G., Jeridi, A., Funk, M., Beroshvili, G., ... Yildirim, A. Ö. (2020). Inhibition of LTβR-signalling activates Wnt-induced regeneration in lung. Nature. doi:10.1038/s41586-020-2882-8

Goffin, E., Jacques, N., Musumeci, L., Nchimi Longang, A., Oury, C., Lancellotti, P., & Pirotte, B. (2020). Synthesis of ticagrelor analogues belonging to 1,2,3-triazolo[4,5-d]pyrimidines and study of their antiplatelet and antibacterial activity. European Journal of Medicinal Chemistry, 208, 112767. doi:10.1016/j.ejmech.2020.112767

Lancellotti, P., Musumeci, L., Jacques, N., Servais, L., Goffin, E., Pirotte, B., & Oury, C. (2019). Antibacterial Activity of Ticagrelor in Conventional Antiplatelet Dosages Against Antibiotic-Resistant Gram-Positive Bacteria. JAMA Cardiology. doi:10.1001/jamacardio.2019.1189

Pirotte, B., Florence, X., Goffin, E., & Lebrun, P. (01 March 2019). 2,2-Dimethyl-3,4-dihydro-2H-1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants. MedChemComm, 10 (3), 431-438. doi:10.1039/c8md00593a

Habila, T., Belghobsi, M., Stiti, M.-Z., Goffin, E., De Tullio, P., Faury, G., Pirotte, B., & Khelili, S. (2019). Synthesis and vasodilator activity of 3,4-dihydropyrimidin-2(1H)-ones bearing urea, thiourea, and sulfonylurea moieties. Canadian Journal of Chemistry, 97 (1), 20 - 28. doi:10.1139/cjc-2018-0239

Drapier, T., Geubelle, P., Bouckaert, C., Nielsen, L., Laulumaa, S., Goffin, E., Dilly, S. A., Francotte, P., Hanson, J., Pochet, L., Kastrup, J., & Pirotte, B. (2018). Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.8b00250

Goffin, E.* , Drapier, T.* , Probst Larsen, A., Geubelle, P., Ptak, C. P., Laulumaa, S., Rovinskaja, K., Gilissen, J., De Tullio, P., Olsen, L., Frydenvang, K., Pirotte, B., Hanson, J., Oswald, R. E., Sandholm Kastrup, J., & Francotte, P. (2018). 7‐Phenoxy-Substituted 3,4-Dihydro‐2H‐1,2,4-benzothiadiazine 1,1- Dioxides as Positive Allosteric Modulators of α‐Amino-3-hydroxy-5- methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. Journal of Medicinal Chemistry, 61, 251-264. doi:10.1021/acs.jmedchem.7b01323

Schnekenburger, M., Goffin, E., Lee, J.-Y., Jang, J. Y., Mazumder, A., Ji, S., Rogister, B., Bouider, N., Lefranc, F., Miklos, W., Mathieu, V., De Tullio, P., Kim, K.-W., Dicato, M., Berger, W., Han, B., Kiss, R., Pirotte, B., & Diederich, M. (08 June 2017). Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. Journal of Medicinal Chemistry, 60 (11), 4714-4733. doi:10.1021/acs.jmedchem.7b00533

Pirotte, B., Florence, X., Goffin, E., & Lebrun, P. (2017). Deciphering Structure-Activity Relationships in a Series of 2,2-Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants. ChemMedChem, 12 (21), 1810-1817. doi:10.1002/cmdc.201700409

Krintel, C.* , Francotte, P.* , Pickering, D. S., Juknaite, L., Pøhlsgaard, J., Olsen, L., Frydenvang, K., Goffin, E., Pirotte, B., & Kastrup, J. (07 June 2016). Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2. Biophysical Journal, 110, 2397-2406. doi:10.1016/j.bpj.2016.04.032

Drapier, T., Geubelle, P., Bouckaert, C., Goffin, E., Dilly, S., Hanson, J., Pochet, L., Kastrup, J. S., Francotte, P., & Pirotte, B. (26 May 2016). DESIGN OF HIGH-AFFINITY LIGANDS FOR THE BENZOTHIADIAZINE ALLOSTERIC BINDING SITE OF THE AMPA RECEPTORS [Poster presentation]. JFB 2016 : 30èmes Journées Franco-Belges de Pharmacochimie 25-27 May 2016 Amboise (France), Amboise, France.

Harrouche, K., Renard, J., Bouider, N., De Tullio, P., Goffin, E., Lebrun, P., Faury, G., Pirotte, B., & Khelili, S. (2016). Synthesis, characterization and biological evaluation of benzothiazoles and tetrahydrobenzothiazoles bearing urea or thiourea moieties as vasorelaxants and inhibitors of the insulin releasing process. European Journal of Medicinal Chemistry, 115, 352-360. doi:10.1016/j.ejmech.2016.03.028

Larsen, A., Francotte, P., Frydenvang, K., Tapken, D., Goffin, E., Fraikin, P., Caignard, D., Lestage, P., Danober, L., Pirotte, B., & Kastrup, J. (2016). Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors. ACS Chemical Neurosciences, 7, 378-390. doi:10.1021/acschemneuro.5b00318

Pirotte, B., Florence, X., Goffin, E., Medeiros, M., De Tullio, P., & Lebrun, P. (2016). 4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion. European Journal of Medicinal Chemistry, 121, 338-351. doi:10.1016/j.ejmech.2016.05.042

Deverdenne, F., Claes, G., Goffin, E., Plenevaux, A., Pirotte, B., Luxen, A., & Francotte, P. (05 June 2015). Design and synthesis of PET-probes targeting AMPA-subtype receptors [Poster presentation]. 29èmes Journées franco-belges de Pharmacochimie, Spa, Belgium.

Drapier, T., Francotte, P., Pirotte, B., Goffin, E. (Other coll.), Hanson, J. (Other coll.), Dilly, S. (Other coll.), & Kastrup, J. (Other coll.). (04 June 2015). Design, synthesis and pharmacological evaluation of dimeric ligands for the benzothiadiazine dioxide allosteric binding site of the AMPA receptors [Paper presentation]. 29ème Journées Franco-Belge de Pharmacochimie, Spa, Belgium.

Deverdenne, F., Claes, G., Goffin, E., Plenevaux, A., Pirotte, B., Luxen, A., & Francotte, P. (13 May 2015). Design and synthesis of PET-probes targeting AMPA subtype receptors [Poster presentation]. The Bioforum 2015 of BioLiège, Liège, Belgium.

Nørholm, A.-B., Francotte, P., Goffin, E., Botez-Pop, I., Danober, L., Lestage, P., Pirotte, B., Olsen, L., & Oostenbrink, C. (24 November 2014). Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces. Journal of Chemical Information and Modeling, 54 (12), 3404-3416. doi:10.1021/ci500559b

Francotte, P.* , Nørholm, A.-B.* , Deva, T., Olsen, L., Frydenvang, K., Goffin, E., Fraikin, P., De Tullio, P., Challal, S., Thomas, J.-Y., Iop, F., Louis, C., Botez-Pop, I., Lestage, P., Danober, L., Kastrup, J. S., & Pirotte, B. (06 November 2014). Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides. Journal of Medicinal Chemistry, 57 (22), 9539-9553. doi:10.1021/jm501268r

Deverdenne, F., Goffin, E., Plenevaux, A., Pirotte, B., Luxen, A., & Francotte, P. (05 June 2014). Design and synthesis of high-affinity ligands of AMPA receptors and study of their Fluorine-18 radiolabeling [Poster presentation]. 28èmes Journées franco-belges de Pharmacochimie, Metz, France.

Drapier, T., Goffin, E., Hanson, J., Dilly, S., Francotte, P., Kastrup, J., & Pirotte, B. (June 2014). DESIGN OF HIGH-AFFINITY LIGANDS FOR THE BENZOTHIADIAZINE ALLOSTERIC BINDING SITE OF THE AMPA RECEPTORS [Poster presentation]. 28èmes Journées franco-belges de Pharmacochimie, Metz, France.

DUBOIS, N., Counerotte, S., Goffin, E., Pirotte, B., & Charlier, C. (April 2014). Validation analytique d'une méthode chromatographique destinée à rechercher et à identifier les opiacés naturels ou (semi) synthétiques. Annales de Biologie Clinique, 72 (2), 197-206. doi:10.1684/abc.2014.0944

Florence, X., Desvaux, V., Goffin, E., De Tullio, P., Pirotte, B., & Lebrun, P. (2014). Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers? European Journal of Medicinal Chemistry, 80, 36-46. doi:10.1016/j.ejmech.2014.04.024

Noerholm, A.-B., Francotte, P., Goffin, E., Botez, L., Danober, L., Lestage, P., Pirotte, B., Kastrup, J. S., Olsen, L., & Oostenbrink, C. (2014). Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces. Journal of Chemical Information and Modeling, 54, 3404-3416.

Nørholm, A.-B., Francotte, P., Olsen, L., Krintel, C., Frydenvang, K., Goffin, E., Challal, S., Danober, L., Botez-Pop, I., Lestage, P., Pirotte, B., & Kastrup, J. S. (16 October 2013). Synthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxide Scaffold. Journal of Medicinal Chemistry, 56 (21), 8736–8745. doi:10.1021/jm4012092

Francotte, P., Goffin, E., Fraikin, P., Graindorge, E., Lestage, P., Danober, L., Challal, S., Rogez, N., Nosjean, O., Caignard, D.-H., Pirotte, B., & De Tullio, P. (03 October 2013). Development of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors. Journal of Medicinal Chemistry, 56 (20), 7838-7850. doi:10.1021/jm400676g

Constant-Urban, C., Charif, M., Goffin, E., VAN HEUGEN, J.-C., Elmoualij, B., CHIAP, P., Mouithys-Mickalad, A., Serteyn, D., Lebrun, P., Pirotte, B., & De Tullio, P. (2013). Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels. Bioorganic and Medicinal Chemistry Letters, 23, 5878-5881. doi:10.1016/j.bmcl.2013.08.091

Pirotte, B., De Tullio, P., Florence, X., Goffin, E., Somers, F., Boverie, S., & Lebrun, P. (2013). 1,4,2-Benzo/pyridodithiazine 1,1-Dioxides Structurally Related to the ATP-Sensitive Potassium Channel Openers 1,2,4-Benzo/pyridothiadiazine 1,1-Dioxides Exert a Myorelaxant Activity Linked to a Distinct Mechanism of Action. Journal of Medicinal Chemistry, 56, 3247-3256. doi:10.1021/jm301743b

Pirotte, B., Francotte, P., Goffin, E., & De Tullio, P. (2013). AMPA receptor positive allosteric modulators: a patent review. Expert Opinion on Therapeutic Patents, 23, 615-628. doi:10.1517/13543776.2013.770840

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., Challal, S., Rogez, N., Nosjean, O., Lesur, B., Botez, I., Pirotte, B., & De Tullio, P. (September 2012). Design, Synthesis and Biological Evaluation of 4-Cycloalkyl-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides Acting as AMPA Potentiators [Poster presentation]. ISMC2012, Berlin, Germany.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., Challal, S., Rogez, N., Nosjean, O., Lesur, B., De Tullio, P., & Pirotte, B. (24 May 2012). Développement d’agents cognitifs agissant par potentialisation des récepteurs AMPA : Design de nouvelles thiénothiadiazine 1,1-dioxydes [Poster presentation]. 26es Journées Franco-Belges de Pharmacochimie, Orléans, France.

Goffin, E., Lamoral-Theys, D., Tajeddine, N., De Tullio, P., Mondin, L., Lefranc, F., Gailly, P., ROGISTER, B., Kiss, R., & Pirotte, B. (2012). N-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis. European Journal of Medicinal Chemistry, 54, 834-44. doi:10.1016/j.ejmech.2012.06.050

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., De Tullio, P., & Pirotte, B. (2011). Development of cognitive enhancers: design of novel thienothiadiazine 1,1-dioxides acting as AMPA potentiators [Paper presentation]. Giga-day, Liège, Belgium.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Lesur, B., Botez, I., Caignard, D.-H., De Tullio, P., & Pirotte, B. (08 September 2010). Development of cognitive enhancers acting through AMPA potentiation: design of novel thienothiadiazine 1,1-dioxides [Poster presentation]. ISMC2010, Bruxelles, Belgium.

Francotte, P., Goffin, E., Fraikin, P., Lestage, P., Van Heugen, J.-C., Gillotin, F., Danober, L., Thomas, J.-Y., Chiap, P., Caignard, D.-H., Pirotte, B., & De Tullio, P. (2010). New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors. Journal of Medicinal Chemistry, 53, 1700-1711. doi:10.1021/jm901495t

Pirotte, B., Francotte, P., Goffin, E., fraikin, P., Danober, L., Lesur, B., Botez, I., Caignard, D. H., Lestage, P., & De Tullio, P. (2010). Ring-fused thiadiazines as core structures for the development of potent AMPA receptor potentiators. Current Medicinal Chemistry, 17, 3575-3582. doi:10.2174/092986710792927859

Francotte, P., Fraikin, P., Goffin, E., Danober, L., Lestage, P., Caignard, D. H., Lesur, B., Botez, I., Van Heugen, J.-C., Chiap, P., Pirotte, B., & De Tullio, P. (May 2009). Stabilisation métabolique par introduction d’atomes de fluor : application aux benzothiadiazine 1,1-dioxydes agissant en tant que potentialisateurs AMPA [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (17 May 2008). Design, synthesis and pharmacological evaluation of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Francotte, P., De Tullio, P., Fraikin, P., Goffin, E., Dintilhac, G., Danober, L., Lestage, P., Lesur, B., Botez, I., Caignard, D. H., & Pirotte, B. (May 2008). Development of cognitive enhancers acting through AMPA potentiation: design of novel benzothiadiazine 1,1-dioxides with improved pharmacokinetic profile [Paper presentation]. 22èmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Francotte, P., Fraikin, P., De Tullio, P., Graindorge, E., Dintilhac, G., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Lesur, B., Caignard, D. H., & Pirotte, B. (May 2007). Design, synthèse et évaluation pharmacologique de 1,2,4-thiénothiadiazine 1,1-dioxydes en tant que nouveaux potentialisateurs AMPA [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Francotte, P., De Tullio, P., Goffin, E., Dintilhac, G., Graindorge, E., Fraikin, P., Lestage, P., Danober, L., Thomas, J.-Y., Caignard, D.-H., & Pirotte, B. (2007). Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. Journal of Medicinal Chemistry, 50 (13), 3153-3157. doi:10.1021/jm070120i

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (August 2006). Design, synthesis and pharmacological evaluation of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. XIXth International Symposium on Medicinal Chemistry, Istanbul, Turkey.

Francotte, P., Fraikin, P., De Tullio, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (June 2006). Design, synthèse et évaluation pharmacologique de 1,2,4-pytridothiadiazine 1,1-dioxydes en tant que nouveaux potentiateurs AMPA [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., & Pirotte, B. (2006). In Search of Novel Ampa Potentiators. Recent Patents on CNS Drug Discovery, 1 (3), 239-46. doi:10.2174/157488906778773661

Lois, F., Wallemacq, P., de Tourtchaninoff, M., Vanbinst, R., Laterre, P.-F., Goffin, E., & Hantson, P. (2006). Prolonged unconsciousness in a patient on automated peritoneal dialysis. European Journal of Emergency Medicine, 13 (6), 361-3. doi:10.1097/01.mej.0000217992.32235.ff

Philippe, G., Angenot, L., De Mol, P., Goffin, E., Hayette, M.-P., Tits, M., & Frederich, M. (21 March 2005). In vitro screening of some Strychnos species for antiplasmodial activity. Journal of Ethnopharmacology, 97 (3), 535-539. doi:10.1016/j.jep.2004.12.011

Ziemons, E., Goffin, E., Lejeune, R., Proença da Cunha, A. P., Angenot, L., & Thunus, L. (January 2005). Supercritical carbon dioxide extraction of tagitinin C from Tithonia diversifolia. Journal of Supercritical Fluids, 33 (1), 53-59. doi:10.1016/j.supflu.2004.04.001

Frederich, M., Tits, M., Goffin, E., Philippe, G., Grellier, P., De Mol, P., Hayette, M.-P., & Angenot, L. (June 2004). In vitro and in vivo antimalarial properties of isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis. Planta Medica, 70 (6), 520-525. doi:10.1055/s-2004-827151

Ziemons, E., Goffin, E., Lejeune, R., Angenot, L., & Thunus, L. (06 February 2004). FT-IR measurement of tagitinin C after solvent extraction from Tithonia diversifolia. Talanta, 62 (2), 383-387. doi:10.1016/j.talanta.2003.08.007

Goffin, E., da Cunha, A. P., Ziemons, E., Tits, M., Angenot, L., & Frederich, M. (November 2003). Quantification of tagitinin C in Tithonia diversifolia by reversed-phase high-performance liquid chromatography. Phytochemical Analysis, 14 (6), 378-80. doi:10.1002/pca.732

Philippe, G., Angenot, L., De Mol, P., Goffin, E., Tits, M., & Frederich, M. (February 2003). In vitro screening of Strychnos species for antiplasmodial activity [Poster presentation]. 27th Landelijk Overleg Farmacognosie (LOF) Symposium, Antwerpen, Belgium.

Ziemons, E., Goffin, E., Lejeune, R., Angenot, L., & Thunus, L. (2003). Supercritical fluid extraction of tagitinin C from Tithonia diversifolia: Comparison of extraction yield and selectivity between supercritical fluid and classical methods of extraction [Paper presentation]. 6th International Symposium on Supercritical fluids, Versailles, France.

Ziemons, E., Goffin, E., Lejeune, R., Angenot, L., & Thunus, L. (2003). Comparison of extraction yield and selectivity between supercritical fluid and classical methods of tagitinin C extraction [Paper presentation]. 11th Forum of Pharmaceutical Sciences, Spa, Belgium.

Goffin, E., Ziemons, E., De Mol, P., de Madureira, M. D. C., Martins, A. P., da Cunha, A. P., Philippe, G., Tits, M., Angenot, L., & Frederich, M. (June 2002). In vitro antiplasmodial activity of Tithonia diversifolia and identification of its main active constituent: tagitinin C. Planta Medica, 68 (6), 543-5. doi:10.1055/s-2002-32552

Goffin, E., Garbacki, N., Damas, J., Tits, M., Angenot, L., & Frederich, M. (2002). Tagitinin C from Tithonia diversifolia : anti-inflammatory activity and high performance liquid chromatogaphic quantification [Poster presentation]. 50th Annual Congress of the Society for Medicinal Plant Research, Barcelona, Spain.

Goffin, E., Frederich, M., Philippe, G., Ziemons, E., De Mol, P., Proença da Cunha, A., Tits, M., & Angenot, L. (September 2001). In vitro antiplasmodial activity of Tithonia diversifolia and identification of its active constituent: tagitinin C [Poster presentation]. Lead Compounds from Higher Plants, Lausanne, Switzerland.

Ziemons, E., Goffin, E., Angenot, L., & Thunus, L. (2001). Extraction of sesquiterpenic lactones with CO2 supercritical fluid and quantification of the extract by FTIR spectroscopy [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.