Publications and communications of Frédéric Billen

Lyssens, A., Janssen, P., Clercx, C., Marichal, T., Radermecker, C., & Billen, F. (18 March 2026). Increased neutrophil extracellular traps formation in the bronchoalveolar lavage fluid of dogs with bronchiectasis. Frontiers in Veterinary Science, 13. doi:10.3389/fvets.2026.1786801

Lyssens, A., Roels, E., Clercx, C., & Billen, F. (14 November 2025). Proposed treatment algorithms for dogs with chronic bronchitis associated with irreversible airway changes: bronchiectasis and/or bronchomalacia. Frontiers in Veterinary Science, 12. doi:10.3389/fvets.2025.1686007

Lyssens, A., Bolen, G., Fastrès, A., Clercx, C., & Billen, F. (18 May 2025). Clinical Relevance of Distinguishing Between Three Endoscopy-Based Conditions, Bronchiectasis, Bronchomalacia, and Their Combination in Dogs: A Retrospective Study. Veterinary Sciences, 12 (5), 487. doi:10.3390/vetsci12050487

Snoeck, A., Jaffey, J. A., Billen, F., Rodrigues, N. F., Peeters, S., Le Goff, C., Cavalier, E., Peeters, D., & Clercx, C. (18 February 2025). Serum 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D are decreased in dogs with sinonasal aspergillosis. Veterinary Journal, 310, 106318. doi:10.1016/j.tvjl.2025.106318

François, C., Billen, F., Noël, S., Etienne, A.-L., Seidel, L., & Bolen, G. (2025). Prevalence and characteristics of bladder wall thickening in dogs without lower urinary tract disease: an ultrasonographic study. Frontiers in Veterinary Science, 12, 1713723. doi:10.3389/fvets.2025.1713723

Lyssens, A., Janssen, P., Clercx, C., Coraline, R., & Billen, F. (2025). Detection of neutrophilic extracellular traps in bronchoalveolar lavage fluid of healthy dogs and of dogs with bronchiectasis, bronchomalacia and bacterial bronchopneumonia [Paper presentation]. ECVIM-CA 35th Annual Congress, Maastricht, Netherlands.

Slusarek, A., Hamaide, A., Lefebvre, M., Heimann, M., Billen, F., & Bolen, G. (2025). Computed tomographic appearance of laryngeal lesions in 7 dogs. Frontiers in Veterinary Science, 12, 1633591. doi:10.3389/fvets.2025.1633591

Machiels, H., Fastrès, A., Lyssens, A., Bienes2;, T., Phan, K.-T., Roels, E., Billen, F., & Clercx, C. (2024). Utility of the IDEXX ProCyte Dx Analyser for the Measurement of Total Cell Counts in Bronchoalveolar Lavage Fluid From Dogs With Lower Airway Disease. Journal of Veterinary Internal Medicine.

Vilcot, M., Roels, E., Clercx, C., & Billen, F. (18 September 2024). Association Between Signalment, Clinical Signs and Nasal Diseases Type and Location in Dogs and Cats [Paper presentation]. 34th Annual ECVIM-CA Congress, Lyon, France.

Vangrinsven, E., Duprez, J. N., Meex, C., Taminiau, B., Daube, G., Billen, F., Mainil, J., & Clercx, C. (June 2024). Comparison of culture-dependent and -independent bacterial detection results on nasal swabs in dogs with nasal discharge. Journal of Small Animal Practice, 65 (6), 376 - 386. doi:10.1111/jsap.13734

Lyssens, A., Biénès, T., Fastrès, A., Machiels, H., Moreau, C., Tutunaru, A.-C., DEVILLE, M., Charlier, C., Clercx, C., & Billen, F. (2024). Three-minute nebulization of gentamicin in healthy dogs results in therapeutic concentrations in bronchoalveolar lavage fluid while remaining below the toxic range values in blood. American Journal of Veterinary Research, 1 - 8. doi:10.2460/ajvr.23.10.0247

Fastrès, A., Vangrinsven, E., Billen, F., Taminiau, B., Daube, G., & Clercx, C. (2024). Lung microbiota assessment in dogs with bronchomalacia. Journal of Veterinary Internal Medicine, 38 (1), 774.

Biénès, T., Lyssens, A., Machiels, H., Hercot, M.-E., Fastrès, A., Alexandru-Cosmin, T., Deville, M., Charlier, C., Billen, F., & Clercx, C. (28 July 2023). Intranasal and Serum Gentamicin Concentration: Comparison of Three Topical Administration Protocols in Dogs. Veterinary Sciences, 10 (8), 490. doi:10.3390/vetsci10080490

Vangrinsven, E., Fastrès, A., Taminiau, B., Billen, F., Daube, G., & Clercx, C. (15 April 2023). Assessment of the nasal microbiota in dogs with fungal rhinitis before and after cure and in dogs with chronic idiopathic rhinitis. BMC Microbiology, 23 (1), 104. doi:10.1186/s12866-023-02828-7

Snoeck, A., Jaffey, J., Billen, F., Peeters, S., Le Goff, C., Peeters, D., Fernandes Rodrigues, N., Cavalier, E., & Clercx, C. (03 November 2022). Serum 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in dogs with sinonasal aspergillosis. Journal of Veterinary Internal Medicine, 36, 2455-2551.

Rodrigues, N. F., Giraud, L., Bolen, G., Fastrès, A., Clercx, C., Boysen, S., Billen, F., & Gommeren, K. (2022). Response to letter regarding "Comparison of lung ultrasound, chest radiographs, C-reactive protein, and clinical findings in dogs treated for aspiration pneumonia". Journal of Veterinary Internal Medicine. doi:10.1111/jvim.16558

Fernandes Rodrigues, N., Giraud, L., Bolen, G., Fastrès, A., Clercx, C., Gommeren, K., & Billen, F. (May 2022). Antimicrobial discontinuation in dogs with acute aspiration pneumonia based on clinical improvement and normalization of C-reactive protein concentration. Journal of Veterinary Internal Medicine, 36 (3), 1082-1088. doi:10.1111/jvim.16405

Fernandes Rodrigues, N., Giraud, L., Bolen, G., Fastrès, A., Clercx, C., Boysen, S., Billen, F., & Gommeren, K. (March 2022). Comparison of lung ultrasound, chest radiographs, C-reactive protein, and clinical findings in dogs treated for aspiration pneumonia. Journal of Veterinary Internal Medicine, 36 (2), 743-752. doi:10.1111/jvim.16379

Gremillet, B., Porsmoguer, C., Bolen, G., Billen, F., Noël, S., Brutinel, F., & Busoni, V. (2022). Imaging Findings in Dogs and Cats With Presumptive Sclerosing Encapsulating Peritonitis. Frontiers in Veterinary Science, 9, 891492. doi:10.3389/fvets.2022.891492

Picavet, P., Hamon, M., Etienne, A.-L., Guieu, L.-V., Claeys, S., Billen, F., & Noël, S. (2022). Laryngeal paralysis secondary to cervical bite injuries in five dogs. New Zealand Veterinary Journal. doi:10.1080/00480169.2021.1951865

Canonne-Guibert, M., Menard, M., Maurey, C., Benchrekroun, G., Fernandes Rodrigues, N., Billen, F., & Clercx, C. (2021). Comparison of C-reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia. Journal of Veterinary Internal Medicine. doi:10.1111/jvim.16091

Vangrinsven, E., Fastrès, A., Taminiau, B., Billen, F., Daube, G., & Clercx, C. (2021). Variations in facial conformation are associated with differences in nasal microbiota in healthy dogs. BMC Veterinary Research, 17 (1), 100. doi:10.1186/s12917-021-03055-w

Biénès, T., Fastrès, A., Vangrinsven, E., Billen, F., Garigliany, M.-M., & Clercx, C. (17 October 2020). Aspergillus qPCR testing on nasal swab: A useful tool for diagnosis and follow‐up of sinonasal aspergillosis in dogs? Journal of Veterinary Internal Medicine, 34 (6), 3058-3166.

Canonne-Guibert, M., Roels, E., Menard, M., Desquilbet, L., Billen, F., & Clercx, C. (September 2020). Clinical response to 2 protocols of aerosolized gentamicin in 46 dogs with Bordetella bronchiseptica infection (2012-2018). Journal of Veterinary Internal Medicine, 34 (5), 2078-2085. doi:10.1111/jvim.15843

Fastrès, A., Canonne-Guibert, M., Taminiau, B., Billen, F., Garigliany, M.-M., Daube, G., & Clercx, C. (2020). Analysis of the lung microbiota in dogs with Bordetella bronchiseptica infection and correlation with culture and quantitative polymerase chain reaction. Veterinary Research, 51 (46), 1-12. doi:10.1186/s13567-020-00769-x

Fastrès, A., Canonne-Guibert, M., Taminiau, B., Billen, F., Garigliany, M.-M., Daube, G., & Clercx, C. (08 November 2019). Analysis of the lung microbiota in dogs with Bordetella bronchiseptica infection and correlation with culture and quantitative polymerase chain reaction [Poster presentation]. 6th FARAH DAY, Liège, Belgium.

Egyptien, S., Shimizu, N., Anne-Archard, N., Billen, F., Deleuze, S., & Noël, S. (26 October 2018). Pyocolpos in a spayed queen with imperforate hymen: a case report [Poster presentation]. FARAH DAY, Liège, Belgium.

Vangrinsven, E., Girod, M., Goossens, D., Desquilbet, L., Clercx, C., & Billen, F. (September 2018). Comparison of two minimally invasive enilconazole perendoscopic infusion protocols for the treatment of canine sinonasal aspergillosis. Journal of Small Animal Practice, 59 (12), 777-782. doi:10.1111/jsap.12933

Hamon, M., Picavet, P., Etienne, A.-L., Guieu, L.-V., Billen, F., & Noël, S. (August 2018). Bilateral laryngeal paralysis secondary to traumatic nerve damage in two dogs [Poster presentation]. European College of Veterinary Surgeons – 27th Annual Scientific Meeting, Athens, Greece.

Canonne, A. M., Billen, F., Losson, B., Peters, I., Schnyder, M., & Clercx, C. (May 2018). Angiostrongylosis in dogs with negative fecal and in-clinic rapid serological tests: 7 Cases (2013-2017). Journal of Veterinary Internal Medicine, 32 (3), 951-955. doi:10.1111/jvim.15092

Broux, O., Clercx, C., Etienne, A.-L., Busoni, V., Claeys, S., Hamaide, A., & Billen, F. (2018). Effects of manipulations to detect sliding hiatal hernia in dogs with brachycephalic airway obstructive syndrome. Veterinary Surgery, 47, 243-251. doi:10.1111/vsu.12735

Vangrinsven, E., Broux, O., Claeys, S., Clercx, C., & Billen, F. (2017). Investigation of laryngeal function and effect of surgery on laryngeal collapse in dogs with brachycephalic syndrome. Journal of Veterinary Internal Medicine, 31, 231.

Roels, E., Bauer, N., LECUT, C., Billen, F., Soete, C., Peters, P., Moritz, A., Gothot, A., & Clercx, C. (September 2016). Investigation of the coagulation system in canine idiopathic pulmonary fibrosis [Poster presentation]. 26 th ECVIM-CA congress, Goteborg, Sweden.

Canonne-Guibert, M., Billen, F., Tual, C., Ramery, E., Roels, E., Peeters, D., & Clercx, C. (July 2016). Quantitative PCR and Cytology of Bronchoalveolar Lavage Fluid in Dogs with Bordetella bronchiseptica Infection. Journal of Veterinary Internal Medicine, 30 (4), 1204-1209. doi:10.1111/jvim.14366

Canonne-Guibert, M., Roels, E., Caron, Y., Losson, B., Bolen, G., Peters, I., Billen, F., & Clercx, C. (2016). Detection of Angiostrongylus vasorum by quantitative PCR in bronchoalveolar lavage fluid in Belgian dogs. Journal of Small Animal Practice, 57 (3), 130-134. doi:10.1111/jsap.12419

Girod, M., Goosens, D., Volpe, R., Clercx, C., & Billen, F. (2016). Comparison of two non-invasive 2% enilconazole infusion protocols for treatment of canine sinonasal aspergillosis and importance of debridement for treatment efficacy. Journal of Veterinary Internal Medicine, 30 (1), 378.

Roels, E., Gommeren, K., Farnir, F., Delvaux, F., Billen, F., & Clercx, C. (2016). Comparison of 4 point-of-care blood gas analyzers for arterial blood gas analysis in healthy dogs and dogs with cardiopulmonary disease. Journal of Veterinary Emergency and Critical Care, 00 (0), 1-8. doi:10.1111/vec.12469

Vangrinsven, E., Broux, O., Claeys, S., Clercx, C., & Billen, F. (2016). Endoscopic investigation of the gastroesophageal junction dynamics in dogs with brachycephalic syndrome. Journal of Veterinary Internal Medicine, 30, 379.

Rizza, M., Liotta, A. P., Billen, F., & Bolen, G. (2015). Tracheal diameter in puppies. Veterinary Radiology and Ultrasound.

Merveille, A.-C., Battaille, G., Billen, F., Deleuze, S., Fredholm, M., Thomas, A., Clercx, C., & Lequarré, A.-S. (May 2014). Clinical findings and prevalence of the mutation associated with primary ciliary dyskinesia in Old English Sheepdogs. Journal of Veterinary Internal Medicine, 28, 771. doi:10.1111/jvim.12336

Merveille, A.-C., Battaille, G., Billen, F., Clercx, C., Georges, M., & Lequarré, A.-S. (2009). Identification of a new mutation responsible for primary ciliary dyskinesia in dogs: a model for human PCD. Journal of Veterinary Internal Medicine.

Billen, F., Clercx, C., & Peeters, D. (2008). Le point sur le diagnostic de l’aspergillose naso-sinusale chez le chien. Annales de Médecine Vétérinaire, 152(2), 61-70.