Maja, M., Verfaillie, M., Van Der Smissen, P., Henriet, P., Pierreux, C. E., Sounni, N. E., & Tyteca, D. (10 January 2024). Targeting cholesterol impairs cell invasion of all breast cancer types. Cancer Cell International, 24 (1), 27. doi:10.1186/s12935-023-03206-z |
Muñoz-Sáez, E., Moracho, N., Learte, A. I. R., Collignon, A., Arroyo, A. G., Noël, A., Sounni, N. E.* , & Sánchez-Camacho, C.*. (09 June 2023). Molecular Mechanisms Driven by MT4-MMP in Cancer Progression. International Journal of Molecular Sciences, 24 (12), 9944. doi:10.3390/ijms24129944 * These authors have contributed equally to this work. |
Azam, A., & Sounni, N. E. (19 December 2022). Lipid Metabolism Heterogeneity and Crosstalk with Mitochondria Functions Drive Breast Cancer Progression and Drug Resistance. Cancers, 14 (24), 6267. doi:10.3390/cancers14246267 |
Rademaker, G.* , Boumahd, Y.* , Peiffer, R., Anania, S., Wissocq, T., Liégeois, M., Luis, G., Sounni, N. E., Agirman, F., Maloujahmoum, N., De Tullio, P., Thiry, M., Bellahcene, A., Castronovo, V., & Peulen, O. (July 2022). Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells. Redox Biology, 53, 102324. doi:10.1016/j.redox.2022.102324 * These authors have contributed equally to this work. |
Gallez, A., Blacher, S., Maquoi, E., Konradowski, E., Joiret, M., Primac, I., Gérard, C., Taziaux, M., Houtman, R., Geris, L., Lenfant, F., Marangoni, E., Sounni, N. E., Foidart, J.-M., Noël, A., & Pequeux, C. (2021). Estetrol combined to progestogen for menopause or contraception indication is neutral on breast cancer. Cancers. doi:10.3390/cancers13102486 |
Luis, G.* , Godfroid, A.* , Nishiumi, S., Cimino, J., Blacher, S., Maquoi, E., Wery, C., Collignon, A., Longuespée, R., MONTERORUIZ, L., Dassoul, I., Maloujahmoum, N., Pottier, C., Mazzucchelli, G., De Pauw, E., Bellahcene, A., Yoshida, M., Noël, A., & Sounni, N. E. (2021). Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence. Redox Biology, 43, 102006. doi:10.1016/j.redox.2021.102006 * These authors have contributed equally to this work. |
POTTIER, C., Fresnais, M., Gilon, M., JERUSALEM, G., Longuespée, R.* , & Sounni, N. E.*. (2020). Tyrosine Kinase Inhibitors in Cancer: Breakthrough and Challenges of Targeted Therapy. Cancers. doi:10.3390/cancers12030731 * These authors have contributed equally to this work. |
Primac, I., Maquoi, E., Blacher, S., Heljasvaara, R., Van Deun, J., Smeland, H. Y. H., Canale, A., Louis, T., Stuhr, L., Sounni, N. E., Cataldo, D., Pihlajaniemi, T., Pequeux, C., De Wever, O., Gullberg, D., & Noël, A. (09 July 2019). Stromal integrin alpha11 regulates PDGFR-beta signaling and promotes breast cancer progression. Journal of Clinical Investigation, 130. doi:10.1172/JCI125890 |
Curtarello, M., Tognon, M., Venturoli, C., Silic-Benussi, M., Grassi, A., Verza, M., Minuzzo, S., Pinazza, M., Brillo, V., Tosi, G., Ferrazza, R., Guella, G., Iorio, E., Godfroid, A., Sounni, N. E., Amadori, A., & Stefano. (2019). Rewiring of Lipid Metabolism and Storage in Ovarian Cancer Cells after Anti-VEGF Therapy. Cells. doi:10.3390/cells8121601 |
Luis, G., Godfroid, A., Blacher, S., Noël, A., Sounni, N. E., Cimino, J. (Other coll.), Nishiumi, S. (Other coll.), & Yoshida, M. (Other coll.). (01 February 2018). Importance of fatty acid desaturation in tumor growth and oxidative stress response occurring during antiangiogenic treatment [Poster presentation]. Séminaire des chercheurs Télévie. |
Luis, G., Godfroid, A., Noël, A., Sounni, N. E., Cimino, J. (Other coll.), Nishiumi, S. (Other coll.), & Yoshida, M. (Other coll.). (27 January 2018). Stearoyl-CoA Desaturase-1 drives cancer malignancy via lipid desaturation and peroxidation after anti-angiogenic treatment withdrawal [Poster presentation]. Belgian Associaition for Cancer Research. |
Gérard, C., Hubeau, C., Carnet, O., Bellefroid, M., Sounni, N. E., Blacher, S., Bendavid, G., Moser, M., Fässler, R., Noël, A., Cataldo, D.* , & Rocks, N.*. (2018). Microenvironment-derived ADAM28 prevents cancer dissemination. Oncotarget, 9 (98), 37185-37199. doi:10.18632/oncotarget.26449 * These authors have contributed equally to this work. |
Marangoni, E., Laurent, C., Coussy, F., El Botty, R., Chateau-Joubert, S., Servely, J.-L., de Plater, L., Assayag, F., Dahmani, A., Montaudon, E., Nemati, F., Fleury, J., Vacher, S., Gentien, D., Rapinat, A., Foidart, P., Sounni, N. E., Noël, A., Salomon, A., ... Reyal, F. (2018). Capecitabine efficacy is correlated with TYMP and RB expression in PDX established from triple-negative breast cancers. Clinical Cancer Research. doi:10.1158/1078-0432.CCR-17-3490 |
Vandereyken, M., Jacques, S., Van Overmeire, E., Amand, M., Rocks, N., Delierneux, C., Singh, P., Singh, M., GHUYSEN, C., Wathieu, C., Zurashvili, T., Sounni, N. E., Moutschen, M., Gilles, C., Oury, C., Cataldo, D., Van Ginderachter, J. A., & Rahmouni, S. (2017). Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner. PLoS ONE. doi:10.1371/journal.pone.0185786 |
Luis, G., Godfroid, A., Noël, A., Sounni, N. E., Cimino, J. (Other coll.), Shin, N. (Other coll.), & Yoshida, M. (Other coll.). (28 January 2017). Fatty acid desaturation promotes tumor growth and aggressiveness after hypoxia and oxygenation [Poster presentation]. Belgian Association for Cancer Research (BACR). |
Yip, C., Foidart, P., Somja, J., Truong, A., Lienard, M., Feyereisen, E., SCHROEDER, H., GOFFLOT, S., Donneau, A.-F., COLLIGNON, J., Delvenne, P., Sounni, N. E., Jerusalem, G., & Noël, A. (2017). MT4-MMP and EGFR expression levels are key biomarkers for breast cancer patient response to chemotherapy and erlotinib. British Journal of Cancer. doi:10.1038/bjc.2017.23 |
Luis, G., Godfroid, A., Noël, A., Sounni, N. E., Cimino, J. (Other coll.), Nishiumi, S. (Other coll.), & Yoshida, M. (Other coll.). (08 December 2016). Importance of fatty acid desaturation in tumor growth and oxidative stress response occurring during antiangiogenic treatment [Poster presentation]. Séminaire des chercheurs Télévie 2017. |
Luis, G., Godfroid, A., Noël, A., Sounni, N. E., Cimino, J. (Other coll.), Nishiumi, S. (Other coll.), & Yoshida, M. (Other coll.). (27 October 2016). Fatty acid desaturation promotes tumor growth and aggressiveness after hypoxia and oxygenation [Poster presentation]. ISCAM. |
Truong, A., Yip, C., PAYE, A., Blacher, S., Munaut, C., Deroanne, C., Noël, A., & Sounni, N. E. (February 2016). Dynamics of Internalization and Recycling of the Pro-Metastatic Membrane Type 4-Matrix Metalloproteinase (MT4-MMP) in Breast Cancer Cells. FEBS Journal, 283 (4), 704-22. doi:10.1111/febs.13625 |
Leroi, N., Sounni, N. E., Van Overmeire, E., Blacher, S., Marée, R., Van Ginderachter, J., Lallemand, F., LENAERTS, E., COUCKE, P., Noël, A.* , & MARTINIVE, P.*. (2015). The timing of surgery after neoadjuvant radiotherapy influences tumor dissemination in a preclinical model. Oncotarget. doi:10.18632/oncotarget.5931 * These authors have contributed equally to this work. |
Paye, A., Truong, A., Yip, C., Cimino, J., Blacher, S., Munaut, C., Cataldo, D., Foidart, J.-M., Maquoi, E., COLLIGNON, J., Delvenne, P., Jerusalem, G., Noël, A.* , & Sounni, N. E.*. (October 2014). EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP. Cancer Research, 74 (23), 6758-70. doi:10.1158/0008-5472.CAN-13-2994 * These authors have contributed equally to this work. |
Noël, A., & Sounni, N. E. (2014). MMP-Mediated Collagen Remodeling and Vessel Functions. In K. BRIX & W. STOCKER (Eds.), Proteases: Structure and Function (édition revue et corrigée, pp. 471-489). Springer-Verlag Wien 2014. doi:10.1007/978-3-7091-0885-7_14 |
Cimino, J., Calligaris, D., Far, J., Debois, D., Blacher, S., Sounni, N. E., Noël, A., & De Pauw, E. (2013). Towards Lipidomics of Low-Abundant Species for Exploring Tumor Heterogeneity Guided by High-Resolution Mass Spectrometry Imaging. International Journal of Molecular Sciences, 14, 24560-24580. doi:10.3390/ijms141224560 |
Detry, B., Blacher, S., Erpicum, C., Paupert, J., Maertens, L., Maillard, C., Munaut, C., Sounni, N. E., LAMBERT, V., Foidart, J.-M., Rakic, J.-M., Cataldo, D., & Noël, A. (2013). Sunitinib inhibits inflammatory corneal lymphangiogenesis. Investigative Ophthalmology and Visual Science, 54 (5), 3082-93. doi:10.1167/iovs.12-10856 |
LAMBERT, V., Lecomte, J., Hansen, S., Blacher, S., Alvarez Gonzalez, M.-L., Struman, I., Sounni, N. E., Rozet, E., De Tullio, P., Foidart, J.-M., Rakic, J.-M., & Noël, A. (2013). Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice. Nature Protocols, 8 (11), 2197-2211. doi:10.1038/nprot.2013.135 |
Cimino, J., Calligaris, D., Debois, D., Sounni, N. E., Noël, A., & De Pauw, E. (04 September 2012). Study of breast cancer adaptation to anti-angiogenic therapies by molecular imaging on tissue slides [Paper presentation]. OurCon 2012 Ourense Conference on Imaging Mass Spectrometry, OurCon Spain, Spain. |
Noël, A., Gutierrez-Fernandez, A., Sounni, N. E., Behrendt, N., Maquoi, E., Lund, I., Cal, S., Hoyer-Hansen, G., & Lopez-Otin, C. (2012). New and Paradoxical Roles of Matrix Metalloproteinases in the Tumor Microenvironment. Frontiers in Pharmacology, 3 (140), 1. doi:10.3389/fphar.2012.00140 |
Sounni, N. E., Paye, A., Host, L., & Noël, A. (13 May 2011). MT-MMPs as regulators of vessel stability associated with angiogenesis. Frontiers in Pharmacology, 2:111. doi:10.3389/fphar.2011.00111 |
Masset, A., Maillard, C., Sounni, N. E., Jacobs, N., Bruyère, F., Delvenne, P., Tacke, M., Reinheckel, T., Foidart, J.-M., Coussens, L., & Noël, A. (2011). Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor. International Journal of Cancer, 128 (2), 283-93. doi:10.1002/ijc.25326 |
Sounni, N. E., Dehne, K., van Kempen, L., Egeblad, M., Affara, N. I., Cuevas, I., Wiessen, J., Junankar, S., Kortes, L., Lee, J., Shen, J., Morrison, C. J., Overall, C. M., Krane, S. M., Werb, Z., Boudreau, N., & Coussens, L. M. (May 2010). Stromal regulation of vessel stability by MMP14 and TGFbeta. Disease Models and Mechanisms, 3, 317-332. doi:10.1242/dmm.003863 |
Sounni, N. E., Rozanov, D. V., Remacle, A. G., Golubkov, V. S., Noël, A., & Strongin, A. Y. (2010). TIMP-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells. International Journal of Cancer, 126 (5), 1067-78. doi:10.1002/ijc.24690 |
Sounni, N. E., Van Kempen, L., Dehne, K., Krane, S., & Cousens, L. (April 2007). Targeting TGFbeta Bioavailability to Regulate Vascular Stability and Leakage. FASEB Journal, 2007; 21:lb33. |
Chabottaux, V., Sounni, N. E., Pennington, C. J., English, W. R., van den Brule, F., Blacher, S., Gilles, C., Munaut, C., Maquoi, E., Lopez-Otin, C., Murphy, G., Edwards, D. R., Foidart, J.-M., & Noël, A. (15 May 2006). Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases. Cancer Research, 66 (10), 5165-5172. doi:10.1158/0008-5472.CAN-05-3012 |
Maquoi, E., Sounni, N. E., Devy, L., Olivier, F., Frankenne, F., Krell, H. W., Grams, F., Foidart, J.-M., & Noël, A. (15 June 2004). Anti-invasive, antitumoral, and antiangiogenic efficacy of a pyrimidine-2,4,6-trione derivative, an orally active and selective matrix metalloproteinases inhibitor. Clinical Cancer Research, 10 (12, Pt 1), 4038-4047. doi:10.1158/1078-0432.CCR-04-0125 |
Noël, A., Maillard, C., Rocks, N., Jost, M., Chabottaux, V., Sounni, N. E., Maquoi, E., Cataldo, D., & Foidart, J.-M. (June 2004). Membrane associated proteases and their inhibitors in tumour angiogenesis. Journal of Clinical Pathology, 57 (6), 577-584. doi:10.1136/jcp.2003.014472 |
Sounni, N. E., Roghi, C., Chabottaux, V., Janssen, M., Munaut, C., Maquoi, E., Galvez, B. G., Gilles, C., Frankenne, F., Murphy, G., Foidart, J.-M., & Noël, A. (02 April 2004). Up-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases. Journal of Biological Chemistry, 279 (14), 13564-13574. doi:10.1074/jbc.M307688200 |
Lang, R., Braun, M., Sounni, N. E., Noël, A., Frankenne, F., Foidart, J.-M., Bode, W., & Maskos, K. (06 February 2004). Crystal structure of the catalytic domain of MMP-16/MT3-MMP: Characterization of MT-MMP specific features. Journal of Molecular Biology, 336 (1), 213-225. doi:10.1016/j.jmb.2003.12.022 |
Sounni, N. E., Janssen, M., Foidart, J.-M., & Noël, A. (March 2003). Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesis [letter to the editor]. Matrix Biology, 22 (1), 55-61. doi:10.1016/S0945-053X(03)00003-9 |
Hajitou, A., Sounni, N. E., Devy, L., Grignet, C., Lewalle, J.-M., Li, H., Deroanne, C., Lu, H., Colige, A., Nusgens, B., Frankenne, F., Maron, A., Yeh, P., Perricaudet, M., Chang, Y., Soria, C., Calberg-Bacq, C.-M., Foidart, J.-M., & Noël, A. (15 April 2001). Down-Regulation of Vascular Endothelial Growth Factor by Tissue Inhibitor of Metalloproteinase-2: Effect on in Vivo Mammary Tumor Growth and Angiogenesis. Cancer Research, 61 (8), 3450-7. |
Maquoi, E., Frankenne, F., Baramova, E., Munaut, C., Sounni, N. E., Remacle, A., Noël, A., Murphy, G., & Foidart, J.-M. (14 April 2000). Membrane Type 1 Matrix Metalloproteinase-Associated Degradation of Tissue Inhibitor of Metalloproteinase 2 in Human Tumor Cell Lines. Journal of Biological Chemistry, 275 (15), 11368-78. doi:10.1074/jbc.275.15.11368 |