Bettendorff, L. (10 July 2023). Synthetic Thioesters of Thiamine: Promising Tools for Slowing Progression of Neurodegenerative Diseases. International Journal of Molecular Sciences, 24, 11296. doi:10.3390/ijms241411296 |
Bettendorff, L. (01 November 2022). Neuroprotective effects of thiamine and precursors with higher bioavailability: focus on benfotiamine and dibenzoylthiamine [Paper presentation]. Paper presented at invited conference at the Burke Neurological Institute (Cornell University), White Plains,New York, United States. |
Probert, F., Gorlova, A., Deikin, A., Bettendorff, L., Veniaminova, E., Nedorubov, A., Chaprov, K. D., Ivanova, T. A., Anthony, D. C., & Strekalova, T. (November 2022). In FUS[1−359]‐tg mice O,S-dibenzoyl thiamine reduces muscle atrophy, decreases glycogen synthase kinase 3 beta, and normalizes the metabolome. Biomedicine and Pharmacotherapy, 156, 113986. doi:10.1016/j.biopha.2022.113986 |
Bettendorff, L. (September 2022). Reduced Nucleotides, Thiols and O2 in Cellular Redox Balance: a Biochemist’s View. Antioxidants, 11, 1877. doi:10.3390/antiox11101877 |
Sambon, M., Pavlova, O., Alhama-Riba, J., Wins, P., Brans, A., & Bettendorff, L. (2022). Product inhibition of mammalian thiamine pyrophosphokinase is an important mechanism for maintaining thiamine diphosphate homeostasis. Biochimica et Biophysica Acta - General Subjects, 1866 (3), 130071. doi:10.1016/j.bbagen.2021.130071 |
Bettendorff, L. (2021). Update on Thiamine Triphosphorylated Derivatives and Metabolizing Enzymatic Complexes. Biomolecules, 11, 1645. doi:10.3390/biom11111645 |
Sambon, M., Wins, P., & Bettendorff, L. (2021). Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine. International Journal of Molecular Sciences, 22, 5418. doi:10.3390/ijms22115418 |
Pavlov, D., Gorlova, A., Bettendorff, L., Kalueff, A. A., Umriukhin, A., Proshin, A., Lysko, A., Landgraf, R., Anthony, D. C., & Strekalova, T. (20 April 2020). Enhanced conditioning of adverse memories in the mouse modified swim test is associated with neuroinflammatory changes - effects that are susceptible to antidepressants. Neurobiology of Learning and Memory, 172, 107227. doi:10.1016/j.nlm.2020.107227 |
Starling-Soares, B., Carrera-Bastos, P., & Bettendorff, L. (April 2020). The role of the synthetic B1 Vitamin sulbutiamine on health - a review. Journal of Nutrition and Metabolism, 2020 (Article ID 9349063), 1-9. doi:10.1155/2020/9349063 |
Sambon, M., Gorlova, A., Demelenne, A., Alhama-Riba, J., Coumans, B., Lakaye, B., Wins, P., Fillet, M., Anthony, D. C., Strekalova, T., & Bettendorff, L. (2020). Dibenzoylthiamine has powerful antioxidant and anti-inflammatory properties in cultured cells and in mouse models of stress and neurodegeneration. Biomedicines, 8, 361. doi:10.3390/biomedicines8090361 |
Sambon, M., NAPP, A., Demelenne, A., Vignisse, J., Wins, P., Fillet, M., & Bettendorff, L. (2019). Thiamine and benfotiamine protect neuroblastoma cells against paraquat and ß- amyloid toxicity by a coenzyme-independent mechanism. Heliyon, 5, 01710. doi:10.1016/j.heliyon.2019.e01710 |
Bakker, J., Balthazart, J., Baron, F., Beguin, Y., Bettendorff, L., Blanpain, C., Bureau, F., Caers, J., Cani, P., Cataldo, D., Cornil, C., Clercx, C., Cloots, R., Colige, A., Daube, G., De Backer, O., de Kerchove d'Exaerde, A., Desmecht, D., Desmet, C., ... Wittamer, V. (2018). La souris, le patient, et le faux expert. Décryptage d'une mystification. Le Vif. L'Express. |
Rademaker, G., Hennequière, V., Nokin, M.-J., LOVINFOSSE, P., Durieux, F., GOFFLOT, S., Bellier, J., Costanza, B., Herfs, M., Peiffer, R., Bettendorff, L., Deroanne, C., Thiry, M., Delvenne, P., Hustinx, R., Bellahcene, A., Castronovo, V., & Peulen, O. (April 2018). Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness. Oncogene, 37 ((32)), 4398-4412. doi:10.1038/s41388-018-0287-z |
Tapias, V., Jainuddin, S., Ahuja, M., Stack, C., Elipenahli, C., Vignisse, J., Gerges, M., Starkova, N., Xu, H., Starkov, A. A., Bettendorff, L., Hushpulian, D. M., Smirnova, N. A., Gazaryan, I. G., Kaidery, N. A., Wakade, S., Calingasan, N. Y., Thomas, B., Gibson, G. E., ... Beal, M. F. (2018). Benfotiamine Treatment Activates the Nrf2/ARE Pathway and is Neuroprotective in a Transgenic Mouse Model of Tauopathy. Human Molecular Genetics, 27 (16), 2874-2892. doi:10.1093/hmg/ddy201 |
Whitfield, K. C., Bourassa, M. W., Adamolekun, B., Bergeron, G., Bettendorff, L., Brown, K. H., Cox, L., Fattal-Valevski, A., Fischer, P. R., Frank, E. L., Hiffler, L., Hlaing, L. M., Jefferds, M. E., Kapner, H., Kounnavong, S., Mousavi, M. P. S., Roth, D. E., Tsaloglou, M.-N., Wieringa, F., & Combs, G. F. J. (2018). Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. Annals of the New York Academy of Sciences, 1430, 3-43. doi:10.1111/nyas.13919 |
Amorim, C., Andris, F., Arckens, L., Arnould, T., Aron, S., Bakker, J., Balligand, M., Balthazart, J., Baron, F., Beck, B., Beguin, Y., Behets, C., Bellefroid, E., Bertrand, L., Bettendorff, L., Bindels, L., Blankert, B., Blanpain, C., Bondue, A., ... Wittamer, V. (2017). L’expérimentation animale reste indispensable (OPINION). La Libre Belgique. |
Hendrick, E., Peixoto, P., Blomme, A., Polese, C., Matheus, N., Cimino, J., Frère, A., Mouithys-Mickalad, A., Serteyn, D., Bettendorff, L., Elmoualij, B., De Tullio, P., Eppe, G., Dequiedt, F., Castronovo, V., & Mottet, D. (2017). Metabolic inhibitors accentuate the anti-tumoral effect of HDAC5 inhibition. Oncogene. doi:10.1038/onc.2017.103 |
Bunik, V., Mkrtchyan, G., Grabarska, A., Oppermann, H., Daloso, D., Araujo, W. L., Juszczak, M., Rzeski, W., Bettendorff, L., Fernie, A. R., Meixensberger, J., Stepulak, A., & Gaunitz, F. (March 2016). Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolismdependent manner. Oncotarget, 7 (26400), 26421. doi:10.18632/oncotarget.8387 |
Mkrtchyan, G., Aleshin, V., Parkhomenko, Y., Kaehne, T., Di Salvo, M. L., Parroni, A., Contestabile, R., Vovk, A., Bettendorff, L., & Bunik, V. (2015). Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis. Scientific Reports, 5, 12583. doi:10.1038/srep12583 |
Bettendorff, L., & Wins, P. (May 2013). Biological functions of thiamine derivatives: Focus on non-coenzyme roles. OA Biochemistry, 1 (1), 10. |
Bunik, Parkhomenko, Y., Kaehne, T., Mkrtchyan, G., Vovk, A., & Bettendorff, L. (March 2013). Thiamine and thiazolium binding proteome includes DJ-1, amyloid beta and several membrane proteins [Poster presentation]. AD/PD 2013 - The 11th International Conference on Alzheimer's & Parkinson's Diseases, Florence, Italy. |
Gigliobianco, T., GANGOLF, M., Lakaye, B., Pirson, B., von Ballmoos, C., Wins, P., & Bettendorff, L. (January 2013). An alternative role of FoF1-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate. Scientific Reports, 3 (1071). doi:10.1038/srep01071 |
Kohn, G., Delvaux, D., Lakaye, B., Servais, A.-C., Scholer, G., Fillet, M., Elias, B., Derochette, J.-M., Crommen, J., Wins, P., & Bettendorff, L. (12 September 2012). High inorganic triphosphatase activities in bacteria and mammalian cells: Identification of the enzymes involved. PLoS ONE, 7 (9), 43879. doi:10.1371/journal.pone.0043879 |
Theatre, E., Frederix, K., Guilmain, W., Delierneux, C., Lecut, C., Bettendorff, L., BOURS, V., & Oury, C. (August 2012). Overexpression of CD39 in mouse airways promotes bacteria induced inflammation. Journal of Immunology, 189 (4), 1966-1974. doi:10.4049/jimmunol.1102600 |
Vignisse, J., Steinbusch, H. W. M., Griegoriev, V., Bettendorff, L., Bolkunov, A., Nunes, J., Bachurin, S., & Strekalova, T. (17 July 2012). Simultaneous versus solitary pharmacological manipulation of NMDA- and AMPA- receptors: effects of new drugs on contextual learning and its extinction [Paper presentation]. 8th FENS Forum of Neuroscience, Barcelona, Spain. |
Hills, J. I., Golub, M. S., Bettendorff, L., & Keen, C. L. (2012). The effect of thiamin tetrahydrofurfuryl disulfide on behavior of juvenile DBA/2J mice. Neurotoxicology and Teratology, 34, 242-252. doi:10.1016/j.ntt.2011.07.006 |
Binet, A., Delvaux, D., & Bettendorff, L. (2011). Une invitée surprise. |
Delvaux, D., Murty, M. R. V. S., Gabelica, V., Lakaye, B., Lunin, V. V., Skarina, T., Onopriyenko, O., Kohn, G., Wins, P., De Pauw, E., & Bettendorff, L. (2011). A specific inorganic triphosphatase from Nitrosomonas europaea: structure and catalytic mechanism. Journal of Biological Chemistry, 286, 34023-34035. doi:10.1074/jbc.M111.233585 |
Gangolf, M., Czerniecki, J., Radermecker, M., Detry, O., NISOLLE, M., JOUAN, C., Martin, D., Chantraine, F., Lakaye, B., Wins, P., Grisar, T., & Bettendorff, L. (October 2010). Thiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells. PLoS ONE, 5 (10), 13616. doi:10.1371/journal.pone.0013616 |
Gigliobianco, T., Lakaye, B., Wins, P., Elmoualij, B., Zorzi, W., & Bettendorff, L. (May 2010). Adenosine thiamine triphosphate accumulates in Escherichia coli cells in response to specific conditions of metabolic stress. BMC Microbiology, 10, 148. doi:10.1186/1471-2180-10-148 |
Gigliobianco, T., Lakaye, B., Makarchikov, A. F., Wins, P., & Bettendorff, L. (2008). Adenylate Kinase-Independent Thiamine Triphosphate Accumulation under Severe Energy Stress in Escherichia Coli. BMC Microbiology, 8, 16. doi:10.1186/1471-2180-8-16 |
Theatre, E., de Leval, L., Bettendorff, L., Bours, V., & Oury, C. (2008). Overexpression of airway CD39 in transgenic mice enhances lipopolysaccharide-induced inflammation. Purinergic Signalling, 4, 113. |
Volvert, M.-L., Seyen, S., Piette, M., Evrard, B., Gangolf, M., Plumier, J.-C., & Bettendorff, L. (2008). Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. BMC Pharmacology, 8, 10. doi:10.1186/1471-2210-8-10 |
Bettendorff, L., Wirtzfeld, B., Makarchikov, A. F., Mazzucchelli, G., Frederich, M., Gigliobianco, T., Gangolf, M., De Pauw, E., Angenot, L., & Wins, P. (2007). Discovery of a natural thiamine adenine nucleotide. Nature Chemical Biology, 3 (4), 211-212. doi:10.1038/nchembio867 |
Makarchikov, A. F., Brans, A., & Bettendorff, L. (2007). Thiamine Diphosphate Adenylyl Transferase from E. Coli: Functional Characterization of the Enzyme Synthesizing Adenosine Thiamine Triphosphate. BMC Biochemistry, 8, 17. doi:10.1186/1471-2091-8-17 |
Makarchikov, A. F., & Bettendorff, L. (2005). Distrribution of specific thiamine triphosphatase in biological objects. News of Biomedical Sciences, 2, 55-60. |
Makarchikov, A. F., & Bettendorff, L. (2004). A study of the quantitative content of thiamine triphosphate in different biological objects by high-performance liquid chromatography. News of Biomedical Sciences, 2, 70-76. |
Nguyen, L., Malgrange, B., Breuskin, I., Bettendorff, L., Moonen, G., Belachew, S., & Rigo, J.-M. (2003). Autocrine/paracrine activation of the GABA(A) receptor inhibits the proliferation of neurogenic polysialylated neural cell adhesion molecule-positive (PSA-NCAM+) precursor cells from postnatal striatum. Journal of Neuroscience, 23 (8), 3278-94. doi:10.1523/jneurosci.23-08-03278.2003 |
Makarchikov, A. F., Luchko, A. A., Bettendorff, L., Lakaye, B., & Wins, P. (2002). Study of the role of ionogenic amino-acid residues in catalytic activity of thiamine triphosphatase from bovine kidney by means of chemical modification. News of Biomedical Sciences, 3, 66-70. |
Makarchikov, A. F., Wins, P., Janssen, E., Wieringa, B., Grisar, T., & Bettendorff, L. (2002). Adenylate kinase 1 knockout mice have normal thiamine triphosphate levels. BBA Molecular Cell Research, 1592 (2), 117-121. doi:10.1016/S0167-4889(02)00277-X |
Bettendorff, L., & Wins, P. (1999). Thiamine derivatives in excitable tissues: Metabolism, deficiency and neurodegenerative diseases. In S. G. Pandalai (Ed.), Recent Research Developments in Neurochemistry, vol 2, part 1 (pp. 37-62). Trivandrum, India: Research Signpost. |
Bettendorff, L., Goessens, G., & Sluse, F. (1997). Reversibility of thiamine deficiency-induced partial necrosis and mitochondrial uncoupling by addition of thiamine to neuroblastoma cell suspensions. Molecular and Cellular Biochemistry, 174 (1-2), 121-4. doi:10.1023/A:1006842609998 |
Bettendorff, L., Sluse, F., Goessens, G., Wins, P., & Grisar, T. (1995). Thiamine Deficiency--Induced Partial Necrosis and Mitochondrial Uncoupling in Neuroblastoma Cells Are Rapidly Reversed by Addition of Thiamine. Journal of Neurochemistry, 65 (5), 2178-2184. doi:10.1046/j.1471-4159.1995.65052178.x |