Publications and communications of Pascale Hubert

Ancion, M., Luyckx, M., Renard, M., Reynders, C., Lerho, T., Bruyère, D., Hendrick, E., Pilard, C., RONCARATI, P., Herfs, M., & Hubert, P. (12 June 2023). Approach using "second generation" immune checkpoint inhibitors for the treatment of triple-negative breast cancer [Poster presentation]. EACR 2023, Turin, Italy.

Reynders, C., RONCARATI, P., Ancion, M., Lerho, T., Luyckx, M., Renard, M., Delvenne, P., Hubert, P., & Herfs, M. (02 February 2023). Histopathological characterization of esophageal tumors and potential involvement of high-risk HPV in carcinogenesis [Poster presentation]. Séminaire des chercheurs Télévie 2023.

Bruyere, D., RONCARATI, P., Lebeau, A., Lerho, T., Poulain, F., Hendrick, E., Pilard, C., Reynders, C., Ancion, M., Luyckx, M., Renard, M., Jacob, Y., Twizere, J.-C., Peiffer, R., Peulen, O., Delvenne, P., Hubert, P., McBride, A., Gillet, N., ... Herfs, M. (2023). Human papillomavirus E6/E7 oncoproteins promote radiotherapy-mediated tumor suppression by globally hijacking host DNA damage repair. Theranostics, 13 (3), 1130 - 1149. doi:10.7150/thno.78091

Reynders, C., Roncarati, P., Ancion, M., Lerho, T., Bruyère, D., Delvenne, P., Hubert, P., & Herfs, M. (29 September 2022). Caractérisations histopathologiques des cancers œsophagiennes et potentiel implication des infections par HPV de haut-risques [Paper presentation]. Conférence annuelle de l'Association Francophone pour l'étude des Infections à Papillomavirus et Polyomavirus 2022, France.

Reynders, C., RONCARATI, P., Ancion, M., Lerho, T., Pilard, C., Bruyère, D., Hendrick, E., Delvenne, P., Hubert, P., & Herfs, M. (09 September 2022). Histopathological characterization of esophageal tumors and potential involvement of high-risk HPV in carcinogenesis [Poster presentation]. INTERUNIVERSITY PHD STUDENT DAY.

Reynders, C., RONCARATI, P., Ancion, M., Lerho, T., Pilard, C., Hendrick, E., Bruyère, D., Delvenne, P., Hubert, P., & Herfs, M. (06 September 2022). Histopathological characterization of esophageal tumors and potential involvement of high-risk HPV infections in carcinogenesis [Poster presentation]. GIGA-Day 2022.

Reynders, C., RONCARATI, P., Ancion, M., Lerho, T., Hendrick, E., Bruyère, D., Pilard, C., Delvenne, P., Hubert, P., & Herfs, M. (08 April 2022). Histopathological characterization of esophageal cancers and potential role of high-risk HPV infections [Poster presentation]. Séminaire des chercheurs Télévie 2022, Belgium.

Lebeau, A.* , Bruyère, D.* , RONCARATI, P., Peixoto, P., Hervouet, E., COBRAIVILLE, G., Taminiau, B., Masson, M., Gallego, C., Mazzucchelli, G., Smargiasso, N., Fleron, M., Baiwir, D., Hendrick, E., Pilard, C., Lerho, T., Reynders, C., Ancion, M., GREIMERS, R., ... Herfs, M. (28 February 2022). HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources. Nature Communications, 13 (1), 1076. doi:10.1038/s41467-022-28724-8
* These authors have contributed equally to this work.

Reynders, C., RONCARATI, P., Ancion, M., Lerho, T., Pilard, C., Bruyère, D., Hendrick, E., Delvenne, P., Hubert, P., & Herfs, M. (14 December 2021). Histopathological characterization of esophageal cancers and potential role of high-risk HPV infections [Poster presentation]. Giga Cancer Day 2021.

Reynders, C., RONCARATI, P., Ancion, M., Lerho, T., Bruyère, D., Hendrick, E., Pilard, C., Hubert, P., Delvenne, P., & Herfs, M. (01 October 2021). Caractérisation histopathologique des cancers œsophagiens et potentiel rôle des HPV [Paper presentation]. Conférence annuelle de l'Association Francophone pour l'étude des Infections à Papillomavirus et Polyomavirus, France.

Bruyère, D., Lebeau, A., RONCARATI, P., Hendrick, E., Masson, M., Twizere, J.-C., Pilard, C., Hubert, P., DELVENNE, P., & Herfs, M. (28 May 2018). Deciphering the radiosensitivity of HPV-positive tumors [Poster presentation]. EDT-Immunology day 2018, Liège, Belgium.

Collignon, E.* , Canale, A.* , Al Wardi, C., Bizet, M., Calonne, E., Dedeurwaerder, S., Garaud, S., Naveaux, C., Barham, W., Wilson, A., Bouchat, S., Hubert, P., Van Lint, C., Yull, F., Sotiriou, C., Willard-Gallo, K., Noël, A.* , & Fuks, F.*. (2018). Immunity drives TET1 regulation in cancer through NF-kappaB. Science Advances, 4 (6), 7309. doi:10.1126/sciadv.aap7309
* These authors have contributed equally to this work.

Lechanteur, A., Furst, T., Delvenne, P., Evrard, B., Hubert, P., & Piel, G. (07 December 2017). Promoting vaginal distribution of two active siRNA-complexed in liposomes for cervical cancer treatment [Paper presentation]. SF Nano Annual Meeting 2017, Bordeaux, France.

Lechanteur, A., Furst, T., Delvenne, P., Evrard, B., Hubert, P., & Piel, G. (05 December 2017). Promoting vaginal distribution of two active siRNA-complexed in liposomes for cervical cancer treatment [Paper presentation]. 4th SF Nano Annual Meeting, Bordeaux, France.

Lechanteur, A., Furst Tania, Evrard, B., Delvenne, P., Hubert, P., & Piel, G. (25 April 2017). Promoting vaginal distribution of two active siRNA-complexed in liposomes for cervical cancer treatment [Paper presentation]. 1st SPLC-Controlled Release Society, Santiago de Compostela, Spain.

Lechanteur, A., Furst, T., Delvenne, P., Evrard, B., Hubert, P., & Piel, G. (2015). Anti-E6/E7/MCL-1 pegylated lipoplexes for a vaginal treatment of cervical cancer [Paper presentation]. 1st European Conference on Pharmaceutics: Drug Delivery, Reims, France.

Suarez-Carmona, M., Bourcy, M., LESAGE, J., Leroi, N., Syne, L., Blacher, S., Hubert, P., Erpicum, C., Foidart, J.-M., Delvenne, P., Birembaut, P., Noël, A., Polette, M., & Gilles, C. (2015). Soluble factors regulated by epithelial-mesenchymal transition mediate tumour angiogenesis and myeloid cell recruitment. Journal of Pathology, 236 (4), 491-504. doi:10.1002/path.4546

Furst, T., Lechanteur, A., Hubert, P., Evrard, B., & Piel, G. (03 November 2014). DEVELOPMENT AND CHARACTERIZATION OF PEGYLATED LIPOPLEXES TO BE ENTRAPPED IN HEC SPONGES FOR VAGINAL DELIVERY [Poster presentation]. 2014 AAPS Annual Meeting and Exposition, San Diego, United States.

Furst, T., Lechanteur, A., Hubert, P., Evrard, B., & Piel, G. (20 October 2014). DEVELOPMENT AND CHARACTERIZATION OF PEGYLATED LIPOPLEXES TO BE ENTRAPPED IN HEC SPONGES FOR VAGINAL DELIVERY [Poster presentation]. 3rd NanoFar Autumn School, Louvain, Belgium.

Lechanteur, A., Furst, T., Kanber, E., Evrard, B., Delvenne, P., Piel, G., & Hubert, P. (04 October 2014). Development and optimization of pegylated lipoplexes for vaginal application [Paper presentation]. SFNano Workshop 2014, Porto, Portugal.

Furst, T., Lechanteur, A., Hubert, P., Evrard, B., & Piel, G. (27 August 2014). DEVELOPMENT OF PEG-COATED LIPOPLEXES TO BE INCORPORATED INTO MUCOADHESIVE HEC-SPONGES [Poster presentation]. Translational Nanomedicine, International Meeting, Angers, France.

Lechanteur, A., Furst, T., Evrard, B., Delvenne, P., Piel, G., & Hubert, P. (19 May 2014). ASSOCIATION OF LIPOSOMES AND siRNA FOR A LOCAL TREATMENT OF CERVICAL CANCER [Poster presentation]. GIGA-Cancer Day 2014.

Furst, T., Lechanteur, A., Hubert, P., Evrard, B., & Piel, G. (03 April 2014). DEVELOPMENT OF PEG-COATED LIPOPLEXES WITH siRNA ANTI E6/E7 ONCOPROTEINS FOR THE TREATMENT OF HPV CANCERS [Poster presentation]. 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbonne, Portugal.

Furst, T., Lechanteur, A., Hubert, P., Evrard, B., & Piel, G. (16 February 2014). Development of PEG-coated lipoplexes with siRNA anti-E6/E7 oncoproteins to be incorporated into mucoadhesive HEC-sponges for the treatment of HPV cancers [Poster presentation]. 10th International Conference and Workshop on Biological Barriers, Saarbrucken, Germany.

Lechanteur, A., Furst, T., Evrard, B., Delvenne, P., Piel, G., & Hubert, P. (16 February 2014). Development of anti-HPV lipoplexes formulations for the treatment of cervical cancer [Poster presentation]. 10th International conference and workshop on Biological Barriers.

Lechanteur, A., Furst, T., Evrard, B., Delvenne, P., Piel, G., & Hubert, P. (27 January 2014). Development of anti-HPV lipoplexes formulations for the treatment of cervical cancer [Poster presentation]. GIGA-Day 2014.

Shostak, K., Zhang, X., Hubert, P., Göktuna, S., Jiang, Z., Klevernic, I., Hildebrand, J., Roncarati, P., Hennuy, B., Ladang, A., SOMJA, J., Gothot, A., Close, P., Delvenne, P., & Chariot, A. (2014). NF-kappaB-induced KIAA1199 promotes survival through EGFR signalling. Nature Communications, 5, 5232. doi:10.1038/ncomms6232

Suarez-Carmona, M., Hubert, P., Gonzalez, A., Duray, A., RONCARATI, P., Erpicum, C., Boniver, J., Castronovo, V., Noël, A., Saussez, S., Peulen, O., Delvenne, P., & Herfs, M. (2014). DeltaNp63 isoform-mediated beta-defensin family up-regulation is associated with (lymph)angiogenesis and poor prognosis in patients with squamous cell carcinoma. Oncotarget, 5 (7), 1856-1868. doi:10.18632/oncotarget.1819

Lechanteur, A., Furst, T., Evrard, B., Delvenne, P., RONCARATI, P., Piel, G., & Hubert, P. (05 December 2013). Development of anti-HPV lipoplexes formulations for the treatment of cervical cancer [Poster presentation]. Séminaire des chercheurs du Télévie 2014.

Lechanteur, A., Furst, T., Evrard, B., Delvenne, P., Piel, G., & Hubert, P. (03 December 2013). Development of anti-HPV lipoplexes for the treatment of cervical cancer [Paper presentation]. 28ième Journées Scientifiques du GTRV, Angers, France.

Furst, T., Lechanteur, A., Hubert, P., Evrard, B., & Piel, G. (02 December 2013). Development of peggylated lipoplexes with siRNA anti-E6/E7 oncoproteins for the treatment og cancers induced by HPV [Poster presentation]. GTRV, Orléans, France.

Lechanteur, A., Furst, T., Evrard, B., Delvenne, P., Piel, G., & Hubert, P. (17 October 2013). Development of anti-HPV lipoplexes for the treatment of cervical cancer [Paper presentation]. Dix-septième forum des sciences pharmaceutiques.

Renauld, J., Johnen, N., Hubert, P., Thelen, N., Cloes, M., & Thiry, M. (28 January 2013). Whole organ culture in rotating bioreactor: the rat embryonic inner ear [Poster presentation]. GIGA-Day, Liège, Belgium.

Lechanteur, A., Furst, T., Evrard, B., Delvenne, P., RONCARATI, P., Piel, G., & Hubert, P. (2013). Development of anti-HPV lipoplexes for the treatment of cervical cancer [Poster presentation]. Cancer GIGA-Day 2013, liège, Belgium.

Lechanteur, A., Evrard, B., Delvenne, P., RONCARATI, P., Hubert, P., & Piel, G. (November 2012). Development and optimization of lipoplex vectors for an antisens therapeutic approach in the context of HPV induced lesions [Poster presentation]. Ecole doctorale en cancérologie expérimentale, liège, Belgium.

Furst, T., Lechanteur, A., Evrard, B., Delvenne, P., Hubert, P., Piette, M., & Piel, G. (22 October 2012). Development of a topical formulation containing lipoplexes able to inhibit E6 and E7 genes for the treatment of cervix cancer caused by HPV16 and HPV18 [Poster presentation]. NanoFar 1st Autumn School, Angers, France.

Lechanteur, A., Furst, T., Evrard, B., Delvenne, P., Hubert, P., & Piel, G. (22 October 2012). Development of a topical formulation containing lipoplexes able to inhibit E6 and E7 genes for the treatment of cervix cancer caused by HPV16 and HPV18 [Poster presentation]. NanoFar Automn School, Angers, France.

Demoulin, S., RONCARATI, P., Delvenne, P., & Hubert, P. (2012). Production of large numbers of plasmacytoid dendritic cells with functional activities from CD34+ hematopoietic progenitor cells: use of IL-3. Experimental Hematology, 40 (4), 268-278. doi:10.1016/j.exphem.2012.01.002

Duray, A., Demoulin, S., Hubert, P., Delvenne, P., & Saussez, S. (2010). Immune suppression in head and neck cancers: a review. Clinical and Developmental Immunology, 2010, 701657. doi:10.1155/2010/701657

Herfs, M., Hubert, P., Kholod, N., Caberg, J.-H., Gilles, C., Berx, G., Savagner, P., Boniver, J., & Delvenne, P. (May 2008). Transforming growth factor-beta1-mediated Slug and Snail transcription factor up-regulation reduces the density of Langerhans cells in epithelial metaplasia by affecting E-cadherin expression. American Journal of Pathology, 172 (5), 1391-402. doi:10.2353/ajpath.2008.071004

Hubert, P., Jacobs, N., Caberg, J.-H., Boniver, J., & Delvenne, P. (October 2007). The cross-talk between dendritic and regulatory T cells: good or evil? Journal of Leukocyte Biology, 82 (4), 781-94. doi:10.1189/jlb.1106694

Delvenne, P., Goffin, F., Kridelka, F., Arafa, M., Carberg, J., Herfs, M., Herman, L., Hubert, P., Jacobs, N., Kholod, N., Foidart, J.-M., & Boniver, J. (2007). La cancer du col utérin: une infection par HPV qui tourne mal. Tempo Médical.

Delvenne, P., Herman, L., Kholod, N., Caberg, J.-H., Herfs, M., Boniver, J., Jacobs, N., & Hubert, P. (2007). Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix. Molecular and Cellular Endocrinology, 264 (1-2), 1-5. doi:10.1016/j.mce.2006.10.014

Hubert, P., Doyen, J., Chapelle, X., Evrard, B., Gerday, C., Boniver, J., Foidart, J.-M., & Jacobs, N. (2007). Phase I/IIclinical trial of local GM-CSF application in patients with cervical HPV-associated low grade squamous intraepithelial lesions [Paper presentation]. 24th International Papillomavirus Conference and Clinical Workshops, Bejing, China.

Jacobs, N., Boniver, J., Hubert, P., & Delvenne, P. (2007). Dendritic Cells: More Than Just Adaptive Immunity Inducers? Current Immunology Reviews, 2, 17-22. doi:10.2174/157339507779802214

Hallez, S., Simon, P., Maudoux, F., Doyen, J., Noël, J.-C., Beliard, A., Capelle, X., Buxant, F., Fayt, I., Lagrost, A.-C., Hubert, P., Gerday, C., Burny, A., Boniver, J., Foidart, J.-M., Delvenne, P., & Jacobs, N. (July 2004). Phase I/II trial of immunogenicity of a human papillomavirus (HPV) type 16 E7 protein-based vaccine in women with oncogenic HPV-positive cervical intraepithelial neoplasia. Cancer Immunology, Immunotherapy, 53 (7), 642-650. doi:10.1007/s00262-004-0501-4

Hubert, P., Evrard, B., Maillard, C., Franzen-Detrooz, E., Delattre, L., Foidart, J.-M., Noël, A., Boniver, J., & Delvenne, P. (2004). Delivery of granulocyte-macrophage colony-stimulating factor in bioadhesive hydrogel stimulates migration of dendritic cells in models human papillomavirus-associated (pre)neoplastic epithelial lesions. Antimicrobial Agents and Chemotherapy, 48 (11), 4342-4348. doi:10.1128/AAC.48.11.4342-4348.2004

Jacobs, N., Renard, I., Al-Saleh, W., Hubert, P., Doyen, J., Kedzia, W., Boniver, J., & Delvenne, P. (2003). Distinct T cell subsets and cytokine production in cultures derived from transformation zone and squamous intraepithelial lesion biopsies of the uterine cervix. American Journal of Reproductive Immunology, 49 (1), 6-13. doi:10.1034/j.1600-0897.2003.01109.x

Delvenne, P., Hubert, P., Jacobs, N., Giannini, S., Havard, L., Renard, I., Saboulard, D., & Boniver, J. (2001). The organotypic culture of HPV-transformed keratinocytes: an effective in vitro model for the development of new immunotherapeutic approaches for mucosal (pre)neoplastic lesions. Vaccine, 19 (17-19), 2557-64. doi:10.1016/S0264-410X(00)00489-8

Jacobs, N., Renard, I., Pisvin, S., Hubert, P., Boniver, J., & Delvenne, P. (2000). IL10 production in cultures of lymphocytes derived from biopsies of normal exocervix, transformation zone and squamous intraepithelial lesion. In J. Monsonego (Ed.), 4th International Multidisciplinary Congress - Eurogin 2000 (pp. 355-362). Pianoro, Italy: International Proceedings Division, Monduzzi Editore.

Hubert, P., Greimers, R., Franzen-Detrooz, E., Sele, J., Delanaye, P., Boniver, J., & Delvenne, P. (October 1998). In Vitro Propagated Dendritic Cells from Patients with Human-Papilloma Virus-Associated Preneoplastic Lesions of the Uterine Cervix: Use of Flt3 Ligand. Cancer Immunology, Immunotherapy, 47 (2), 81-9. doi:10.1007/s002620050507