Publications and communications of Akeila Bellahcene

Ruscitti, C., Abinet, J., Maréchal, P., Meunier, M., de Meeûs, C., Vanneste, D., Janssen, P., Dourcy, M., Thiry, M., Bureau, F., Schneider, C., Machiels, B., Hidalgo, A., Ginhoux, F., Dewals, B. G., Guiot, J., Schleich, F., Garigliany, M.-M., Bellahcene, A., ... Marichal, T.*. (02 August 2024). Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury. Science Immunology, 9 (98), 1227. doi:10.1126/sciimmunol.ado1227

Anania, S., Farnir, M., Peiffer, R., Boumahd, Y., Thiry, M., Agirman, F., Maloujahmoum, N., Bellahcene, A., & Peulen, O. (17 February 2024). Identification of myoferlin as a mitochondria-associated membranes component required for calcium signaling in PDAC cell lines. Cell Communication and Signaling, 22 (1), 133. doi:10.1186/s12964-024-01514-z

Crake, R., Gasmi, I., Dehaye, J., Lardinois, F., Peiffer, R., Maloujahmoum, N., Agirman, F., KOOPMANSCH, B., D’Haene, N., Azurmendi Senar, O., Arsenijevic, T., Lambert, F., Peulen, O., Van Laethem, J.-L., & Bellahcene, A. (17 May 2023). Resistance to Gemcitabine in Pancreatic Cancer Is Connected to Methylglyoxal Stress and Heat Shock Response. Cells, 12 (10), 1414. doi:10.3390/cells12101414

Dube, G., Tiamiou, A., Bizet, M., Boumahd, Y., Gasmi, I., Crake, R., Bellier, J., Nokin, M.-J., Calonne, E., Deplus, R., Wissocq, T., Peulen, O., Castronovo, V., Fuks, F., & Bellahcene, A. (31 March 2023). Methylglyoxal: a novel upstream regulator of DNA methylation. Journal of Experimental and Clinical Cancer Research, 42 (1), 78. doi:10.1186/s13046-023-02637-w

Peiffer, R., Boumahd, Y., Gullo, C., Crake, R., Letellier, E., Bellahcene, A., & Peulen, O. (22 December 2022). Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer. Cancers, 15 (1), 61. doi:10.3390/cancers15010061

Mouziane, L., Crake, R., Maloujahmoum, N., Agirman, F., Roncarati, P., Herfs, M., & Bellahcene, A. (30 September 2022). Characterisation of methylglyoxal stress in human colorectal cancer and liver metastases using immunohistochemistry [Poster presentation]. BACR, Gent, Belgium.

Rademaker, G.* , Boumahd, Y.* , Peiffer, R., Anania, S., Wissocq, T., Liégeois, M., Luis, G., Sounni, N. E., Agirman, F., Maloujahmoum, N., De Tullio, P., Thiry, M., Bellahcene, A., Castronovo, V., & Peulen, O. (July 2022). Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells. Redox Biology, 53, 102324. doi:10.1016/j.redox.2022.102324

Boumahd, Y., Rademaker, G., Peiffer, R., Anania, S., Agirman, F., Maloujahmoum, N., Bellahcene, A., & Peulen, O. (22 June 2022). Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells [Poster presentation]. EACR 2022.

Rademaker, G., Costanza, B., Pyr Dit Ruys, S., Peiffer, R., Agirman, F., Maloujahmoum, N., Vertommen, D., Turtoi, A., Bellahcene, A., Castronovo, V.* , & Peulen, O.*. (2022). Paladin, overexpressed in colon cancer, is required for actin polymerisation and liver metastasis dissemination. Oncogenesis, 11, 42. doi:10.1038/s41389-022-00416-4

Boumahd, Y., Rademaker, G., Peiffer, R., Anania, S., Maloujahmoum, N., Agirman, F., Bellahcene, A., & Peulen, O. (14 December 2021). Myoferlin targeting primes ferroptosis in pancreatic cancer cells [Poster presentation]. GIGA cancer day.

Crake, R., Agirman, F., Arsenijevic, T., Maloujahmoum, N., Peulen, O., Van Laethem, J.-L., & Bellahcene, A. (14 October 2021). Improving pancreatic cancer response to gemcitabine by overcoming methylglyoxal driven suppression of AMPK [Poster presentation]. GIGA-Cancer Day, Liege, Belgium.

Luis, G.* , Godfroid, A.* , Nishiumi, S., Cimino, J., Blacher, S., Maquoi, E., Wery, C., Collignon, A., Longuespée, R., MONTERORUIZ, L., Dassoul, I., Maloujahmoum, N., Pottier, C., Mazzucchelli, G., De Pauw, E., Bellahcene, A., Yoshida, M., Noël, A., & Sounni, N. E. (2021). Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence. Redox Biology, 43, 102006. doi:10.1016/j.redox.2021.102006

Anania, S., Peiffer, R., Rademaker, G., Hego, A., Thiry, M., Deldicque, L., Francaux, M., Maloujahmoum, N., Agirman, F., Bellahcene, A., Castronovo, V., & Peulen, O. (21 June 2020). Myoferlin is a yet unknown interactor of the mitochondrial dynamics’ machinery in pancreas cancer cells. Cancers, 12 (6), 1643. doi:10.3390/cancers12061643

Bellier, J., Nokin, M.-J., Caprasse, M., Tiamiou, A., Blomme, A., Scheijen, J. L., KOOPMANSCH, B., MacKay, G. M., Chiavarina, B., Costanza, B., Rademaker, G., Durieux, F., Agirman, F., Maloujahmoum, N., Cusumano, P. G., LOVINFOSSE, P., Leung, H. Y., LAMBERT, F., Bours, V., ... Bellahcene, A. (04 February 2020). Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab. Cell Reports, 30 (5), 1400-1416.e6. doi:10.1016/j.celrep.2020.01.012

Anania, S., Rademaker, G., Peiffer, R., Hego, A., Deldicque, L., Maloujahmoum, N., Agirman, F., Bellahcene, A., Castronovo, V., & Peulen, O. (February 2020). Role of myoferlin in mitochondrial dynamics and metabolic fitness of pancreas cancer [Poster presentation]. BACR Annual Meeting 2020 - Cancer metastases: from bedside to bench, Brussels, Belgium.

Anania, S., Rademaker, G., Bellahcene, A., Castronovo, V., & Peulen, O. (December 2019). Role of myoferlin in mitochondrial dynamics and metabolic fitness of Pancreatic Ductal Adenocarcinoma [Poster presentation]. Second CIRM Scientific Day, Liège, Belgium.

Rademaker, G., Costanza, B., Bellier, J., Herfs, M., Agirman, F., Maloujahmoum, N., Bellahcene, A., Castronovo, V., & Peulen, O. (26 November 2019). Myoferlin depletion induces DNA damage response and p53- dependent cell cycle arrest and apoptosis in colon cancer [Poster presentation]. Metabolism in Cancer and Stromal Cells (2nd edition), Leuven, Belgium.

Rademaker, G., Costanza, B., Anania, S., Agirman, F., Maloujahmoum, N., Bellahcene, A., Castronovo, V., & Peulen, O. (23 October 2019). Myoferlin Contributes to the Metastatic Phenotype of Pancreatic Cancer Cells by Enhancing Their Migratory Capacity Through the Control of Oxidative Phosphorylation [Poster presentation]. Pancreatic Cancer Symposium, Toulouse, France.

Anania, S., Rademaker, G., Wissocq, T., Bellahcene, A., Castronovo, V., & Peulen, O. (October 2019). Role of myoferlin in mitochondrial dynamics and metabolic fitness of PDAC [Poster presentation]. PANCREATIC CANCER SYMPOSIUM, Toulouse, France.

Costanza, B., Rademaker, G., Turtoi, A., Bellahcene, A., Castronovo, V., & Peulen, O. (October 2019). TGFBI, an ECM interacting protein, enhances glycolysis and promotes pancreatic cancer cell migration [Poster presentation]. Pancreatic Cancer Symposium 2019, Toulouse, France.

Anania, S., Rademaker, G., Wissocq, T., Bellahcene, A., Castronovo, V., & Peulen, O. (06 September 2019). Role of myoferlin in mitochondrial dynamics and metabolic fitness of pancreas cancer [Poster presentation]. EDT Cancerology 2019, Bruxelles, Belgium.

Peulen, O., Rademaker, G., Anania, S., Turtoi, A., Bellahcene, A., & Castronovo, V. (August 2019). Ferlin overview: from membrane to cancer biology. Cells, 8, 954. doi:10.3390/cells8090954

Rademaker, G., Costanza, B., Anania, S., Agirman, F., Maloujahmoum, N., Bellahcene, A., Castronovo, V., & Peulen, O. (13 June 2019). Myoferlin Contributes to the Metastatic Phenotype of Pancreatic Cancer Cells by Enhancing Their Migratory Capacity Through the Control of Oxidative Phosphorylation [Poster presentation]. Belgian Society for Cell and Developmental Biology - Spring Meeting, Liège, Belgium.

Rademaker, G., Costanza, B., Anania, S., Agirman, F., Maloujahmoum, N., Di Valentin, E., Goval, J.-J., Bellahcene, A., Castronovo, V., & Peulen, O. (June 2019). Myoferlin contributes to the metastatic phenotype of pancreatic cancer cells by enhancing their migratory capacity through the control of oxidative phosphorylation. Cancers, 11 (6). doi:10.3390/cancers11060853

Costanza, B., Rademaker, G., Tiamiou, A., De Tullio, P., Leenders, J., Blomme, A., Bellier, J., Bianchi, E., Turtoi, A., Delvenne, P., Bellahcene, A., Peulen, O.* , & Castronovo, V.*. (2019). TGFBI, an ECM interacting protein, enhances glycolysis and promotes pancreatic cancer cell migration. International Journal of Cancer. doi:10.1002/ijc.32247

Rademaker, G., Costanza, B., Bellier, J., Herfs, M., Peiffer, R., Agirman, F., Maloujahmoum, N., Habraken, Y., Delvenne, P., Bellahcene, A., Castronovo, V.* , & Peulen, O.*. (2019). Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis. Oncogenesis. doi:10.1038/s41389-019-0130-6

Rademaker, G., Hennequière, V., Nokin, M.-J., LOVINFOSSE, P., Durieux, F., GOFFLOT, S., Bellier, J., Costanza, B., Herfs, M., Peiffer, R., Bettendorff, L., Deroanne, C., Thiry, M., Delvenne, P., Hustinx, R., Bellahcene, A., Castronovo, V., & Peulen, O. (April 2018). Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness. Oncogene, 37 ((32)), 4398-4412. doi:10.1038/s41388-018-0287-z

Costanza, B., Turtoi, A., Bellahcene, A., Hirano, T., Peulen, O., Blomme, A., Hennequiere, J., MUTIJIMA NZARAMBA, E., Boniver, J., Meuwis, M.-A., JOSSE, C., KOOPMANSCH, B., SEGERS, K., Yokobori, T., Fahmy, K., Thiry, M., COIMBRA MARQUES, C., Garbacki, N., Colige, A., ... Castronovo, V. (2018). Innovative methodology for the identification of soluble biomarkers in fresh tissues. Oncotarget, 9 (12), 10665-10680. doi:10.18632/oncotarget.24366

Nokin, M.-J., Durieux, F., Bellier, J., Peulen, O., Uchida, K., Spiegel, D. A., Cochrane, J. R., Hutton, C. A., Castronovo, V., & Bellahcene, A. (2017). Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death. Scientific Reports, 7 (1), 11722. doi:10.1038/s41598-017-12119-7

Nokin, M.-J., Durieux, F., Peixoto, P., Chiavarina, B., Peulen, O., Blomme, A., Turtoi, A., Costanza, B., Smargiasso, N., Baiwir, D., Scheijen, J., Schalkwijk, C., Leenders, J., De Tullio, P., BIANCHI, E., Thiry, M., Uchida, K., Spiegel, D., Cochrane, J., ... Bellahcene, A. (2016). Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP- mediated tumor growth and metastasis. eLife. doi:10.7554/eLife.19375

Binsfeld, M., Muller, J., Lamour, V., De Veirman, K., De Raeve, H., Bellahcene, A., Van Valckenborgh, E., BARON, F., BEGUIN, Y., CAERS, J., & Heusschen, R. (2016). Granulocytic myeloid-derived suppressor cells promote angiogenesis in the context of multiple myeloma. Oncotarget, 7, 37931-37943. doi:10.18632/oncotarget.9270

Blomme, A., Cusumano, P., Peulen, O., Bellahcene, A., Castronovo, V., & Turtoi, A. (2016). L'asporine : une nouvelle defense naturelle contre le cancer du sein. MS. Medecine Sciences, 32 (11), 1019-1022. doi:10.1051/medsci/20163211020

Costanza, B., Blomme, A., Bellahcene, A., Peulen, O., MUTIJIMA NZARAMBA, E., DELVENNE, P., De Pauw, E., DETRY, O., COIMBRA MARQUES, C., Castronovo, V., & Turtoi, A. (2016). EXPEL: A Novel Non-Destructive Method for Mining Soluble Tumor Biomarkers. Acta Gastro-Enterologica Belgica, 79 (1), 11.

Fradet, A., Bouchet, M., Delliaux, C., Gervais, M., Kan, C., Benetollo, C., Pantano, F., Vargas, G., Bouazza, L., Croset, M., Bala, Y., Leroy, X., Rosol, T. J., Rieusset, J., Bellahcene, A., Castronovo, V., Aubin, J. E., Clezardin, P., Duterque-Coquillaud, M., & Bonnelye, E. (2016). Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone. Oncotarget, 7 (47), 77071-77086. doi:10.18632/oncotarget.12787

Fahmy, K., Peulen, O., Castronovo, V., Bellahcene, A., Turtoi, A., Thiry, M., Delvenne, P., PEIXOTO, P., Gonzalez, A., & ARAFA, M. (31 January 2015). Myoferlin: an indispensable component in VEGFA secretion by pancreas cancer cells [Poster presentation]. ASSOCIATION BELGE POUR L'ETUDE DU CANCER, Bruxelles, Belgium.

Fahmy, K., Gonzalez, A., Arafad, M., Turtoi, A., Bellahcene, A., DELVENNE, P., Thiry, M., Castronovo, V., & Peulen, O. (27 January 2015). Myoferlin: an indispensable component in VEGR-A secretion by pancreatic cancer cell [Poster presentation]. GIGA-DAY: Current advances in medical genetics and genomics, Liège, Belgium.

Nokin, M.-J., Durieux, F., Peixoto, P., Chiavarina, B., Smargiasso, N., Baiwir, D., De Pauw, E., De Tullio, P., Thiry, M., Peulen, O., Turtoi, A., Castronovo, V., & Bellahcene, A. (27 January 2015). Accumulation of methylglyoxal, a glycolysis by-product modulates YAP1 transcription co-factor localization and activity in human breast cancer cells through HSP90 modification [Poster presentation]. GIGA-DAY: Current advances in medical genetics and genomics, Liège, Belgium.

Costanza, B., Blomme, A., Bellahcene, A., MUTIJIMA NZARAMBA, E., Peulen, O., & DELVENNE, P. (January 2015). EXPEL: A Novel Non-Destructive Method for Mining Soluble Tumor Biomarkers [Poster presentation]. Belgian Association Cancer Research.

Maris, P., Blomme, A., Palacios, A. P., Costanza, B., Bellahcene, A., BIANCHI, E., GOFFLOT, S., Drion, P., Trombino, G. E., Di Valentin, E., CUSUMANO, G., MAWEJA, S., JERUSALEM, G., Delvenne, P., LIFRANGE, E., Castronovo, V., & Turtoi, A. (2015). Asporin Is a Fibroblast-Derived TGF-beta1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer. PLoS Medicine, 12 (9), 1001871. doi:10.1371/journal.pmed.1001871

Mskhiladze, L., Chincharadze, D., Tits, M., Wauters, J.-N., Bellahcene, A., Castronovo, V., Mouithys-Mickalad, A., Franck, T., & Frederich, M. (2015). Identification of Cytotoxic and Antioxidant Compounds from Allium gramineum Flowers. International Journal of Pharmaceutical Sciences and Drug Research, 7, 78-82.

Binsfeld, M., Heusschen, R., Lamour, V., Van Valckenborgh, E., Bellahcene, A., Baron, F., BEGUIN, Y., & CAERS, J. (2014). Multiple myeloma cells instruct myeloid-derived suppressor cells to release pro-angiogenic cytokines. Belgian Journal of Hematology.

Costanza, B., Blomme, A., Bellahcene, A., Hennequière, V., LIFRANGE, E., DELVENNE, P., Castronovo, V., & Turtoi, A. (2014). Myoferlin is a Key Regulator of HER Receptor Family Function in Breast Cancer [Paper presentation]. EDT Annual Mini symposium 2014.

Tilli, T. M., Bellahcene, A., Castronovo, V., & Gimba, E. R. P. (2014). Changes in the transcriptional profile in response to overexpression of the osteopontin-c splice isoform in ovarian (OvCar-3) and prostate (PC-3) cancer cell lines. BMC Cancer, 14, 433. doi:10.1186/1471-2407-14-433

bournine, L., Bensalem, S., Wauters, J.-N., Iguer-Ouada, M., Maiza-Benabdesselam, F., Bedjou, F., Castronovo, V., Bellahcene, A., Tits, M., & Frederich, M. (2013). Identification and Quantification of the Main Active Anticancer Alkaloids from the Root of Glaucium flavum. International Journal of Molecular Sciences, 14, 23533-23544. doi:10.3390/ijms141223533

Fradet, A., Sorel, H., Depalle, B., Serre, C. M., Farlay, D., Turtoi, A., Bellahcene, A., Follet, H., Castronovo, V., Clezardin, P., & Bonnelye, E. (2013). A new murine model of osteoblastic/osteolytic lesions from human androgen-resistant prostate cancer. PLoS ONE, 8 (9), 75092. doi:10.1371/journal.pone.0075092

Lamour, V., Nokin, M.-J., Henry, A., Castronovo, V., & Bellahcene, A. (2013). Les proteines SIBLING - Outils moleculaires de la progression tumorale et de l'angiogenese. MS. Medecine Sciences, 29 (11), 1018-25. doi:10.1051/medsci/20132911019

Turtoi, A.* , Blomme, A.* , Bellahcene, A., Gilles, C., Hennequière, V., Peixoto, P., BIANCHI, E., Noël, A., De Pauw, E., LIFRANGE, E., Delvenne, P., & Castronovo, V. (2013). Myoferlin is a key regulator of EGFR activity in breast cancer. Cancer Research, 73, 5438-5448. doi:10.1158/0008-5472.CAN-13-1142

Dumont, B., Castronovo, V., Peulen, O., BLETARD, N., Clézardin, P., Delvenne, P., De Pauw, E., Turtoi, A., & Bellahcene, A. (2012). Differential proteomic analysis of a human breast tumor and its matched bone metastasis identifies cell membrane and extracellular proteins associated with bone metastasis. Journal of Proteome Research. doi:10.1021/pr201022n

Tilli, T. M., Mello, K. D., Ferreira, L. B., Matos, A. R., Accioly, M. T., Faria, P. A., Bellahcene, A., Castronovo, V., & Gimba, E. R. (2012). Both osteopontin-c and osteopontin-b splicing isoforms exert pro-tumorigenic roles in prostate cancer cells. Prostate. doi:10.1002/pros.22523

Turtoi, A., Mottet, D., Matheus, N., Dumont, B., Peixoto, P., Hennequière, V., Deroanne, C., Colige, A., De Pauw, E., Bellahcene, A., & Castronovo, V. (2012). The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells. Angiogenesis. doi:10.1007/s10456-012-9279-8

Fradet, A., Sorel, H., Bouazza, L., Goehrig, D., Depalle, B., Bellahcene, A., Castronovo, V., Follet, H., Descotes, F., Aubin, J. E., Clezardin, P., & Bonnelye, E. (2011). Dual function of ERR alpha in breast cancer and bone metastasis formation: implication of VEGF and osteoprotegerin. Cancer Research, 71 (17), 5728-38. doi:10.1158/0008-5472.CAN-11-1431

Bellahcene, A., Merville, M.-P., Gielen Jacques, Lambotte, R., Simar, L., & Castronovo, V. (01 May 1994). La protéine P53, protectrice de l'intégrité du génome: rôle dans la genèse des cancers. Revue Médicale de Liège, 49 (5), 274-84.