Publications and communications of Brigitte Malgrange

Gauthy, C., Cole, N., Spahic, E., Closset, R., Hendrickx, E., Conrard, L., Bodadi, Y., Magdalena Segura, H., Tallandier, V., Van Lerberghe, P.-B., Collard, L., Penoy, N., Boschini, F., Evrard, B., Delacroix, L., Malgrange, B.* , & Piel, G.*. (20 May 2026). Development of a Thermosensitive Hydrogel Containing Liposomes for Sustained Dexamethasone Delivery in Sensorineural Hearing Loss. International Journal of Pharmaceutics, 697, 126847. doi:10.2139/ssrn.6222330

Delacroix, L., Pouyo, L. R., Spahic, E., Thelen, N., Shostak, K., & Malgrange, B. (07 February 2026). Exploring the Role of Nedd4-2 Ubiquitin Ligase in Hearing Function [Paper presentation]. ARO 49th Midwinter Meeting, San Juan, Puerto Rico, United States.

Gauthy, C., Magdalena Segura, H., Bodadi, Y., Spahic, E., Cole, N., Collard, L., Penoy, N., Evrard, B., Malgrange, B., & Piel, G. (02 October 2025). In vitro and ex vivo validation of a P407 hydrogel dispersing liposomes for sustained dexamethasone release using hSAE and HEI-OC1 cells, cochlear explants and a round window membrane (RWM) model [Paper presentation]. 5th Conference on Innovation in Drug Delivery.

Gauthy, C., Bodadi, Y., Magdalena Segura, H., Penoy, N., Collard, L., Evrard, B., Malgrange, B., & Piel, G. (27 May 2025). Characterization of a P407 hydrogel dispersing liposomes for sustained release of dexamethasone for deposition on an in vitro RWM model [Poster presentation]. NanoMed Europe 2025.

Gauthy, C., Magdalena Segura, H., Bodadi, Y., Collard, L., Penoy, N., Evrard, B., Malgrange, B., & Piel, G. (31 March 2025). Development of a P407 Hydrogel Containing Liposomes Produced by Supercritical CO₂ for Sustained Dexamethasone Delivery in Sensorineural Hearing Loss [Paper presentation]. 22nd FORUM OF PHARMACEUTICAL SCIENCES, La Roche-en-Ardenne, Belgium.

Gauthy, C., Magdalena Segura, H., Bodadi, Y., Collard, L., Evrard, B., Malgrange, B., & Piel, G. (14 February 2025). Dispersion of Liposomes Produced by a Supercritical CO₂ process in Thermosensitive Hydrogel for Intratympanic Injection [Paper presentation]. CRS Local Chapter DeChAt 2025, Berne, Switzerland.

Tielens, S., Boutin, C., Huysseune, S., Thelen, N., Charlet-Briart, M., Reyskens, C., Oskera, L., Boutsen, A., Mateo-Sanchez, S., Delacroix, L., Labedan, P., Thiry, M., Malgrange, B., Chariot, A., Tissir, F., Creppe, C., Seuntjens, E., Laguesse, S., & Nguyen, L. (2025). Loss of Elp3 impairs the maturation tempo of brain ependymal cells. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/328565. doi:10.1101/2025.01.07.631730

Gauthy, C., Magdalena Segura, H., Evrard, B., Malgrange, B., & Piel, G. (04 December 2024). Transfer of the Liposome Encapsulating Dexamethasone Production Method to a CO2 PGSS Supercritical Process [Poster presentation]. SFNano 2024, Toulouse, France.

Gauthy, C., Gihozo Uwera, A., Evrard, B., Malgrange, B., & Piel, G. (10 April 2024). Effect of the composition of liposomes on dexamethasone encapsulation and its kinetics of release [Poster presentation]. ESCDD Symposium 2024, Egmond aan Zee, Netherlands.

Gauthy, C., Evrard, B., Malgrange, B., & Piel, G. (19 March 2024). Optimization of liposomal formulation to achieve sustained release of dexamethasone [Poster presentation]. 14th PBP World Meeting, Vienne, Austria.

Gauthy, C., Gihozo Uwera, A., Evrard, B., Malgrange, B., & Piel, G. (31 January 2024). Optimization of liposomal composition to efficiently encapsulate dexamethasone or dexamethasone phosphate and enable their sustained release [Poster presentation]. CIRM Day, Liège, Belgium.

Pressé, M., Malgrange, B., & Delacroix, L. (2024). The Cochlear Matrisome: Importance in Hearing and Deafness. Matrix Biology: Journal of the International Society for Matrix Biology, 125, 40 - 58. doi:10.1016/j.matbio.2023.12.002

Veithen, M.* , Huyghe, A.* , Van Den Ackerveken, P., Fukada, S.-I., Kokubo, H., Breuskin, I., Nguyen, L., Delacroix, L.* , & Malgrange, B.*. (25 August 2023). Sox9 Inhibits Cochlear Hair Cell Fate by Upregulating Hey1 and HeyL Antagonists of Atoh1. Cells, 12 (17), 2148. doi:10.3390/cells12172148

Chohra, I., Giri, S., & Malgrange, B. (23 June 2023). Generation of a Well-Characterized Homozygous Chromodomain-Helicase-DNA-Binding Protein 4G1003D Mutant hESC Line Using CRISPR/eCas9 (ULIEGEe001-A-1). International Journal of Molecular Sciences, 24 (13), 10543. doi:10.3390/ijms241310543

Gauthy, C., Penoy, N., Evrard, B., Malgrange, B., & Piel, G. (28 April 2023). Development of optimized liposomes for sustained-release transtympanic administration [Paper presentation]. 21st Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

D'Aes, T., Marlier, Q., Verteneuil, S., Quatresooz, P., Vandenbosch, R.* , & Malgrange, B.*. (10 April 2023). Re-Evaluating the Relevance of the Oxygen-Glucose Deprivation Model in Ischemic Stroke: The Example of Cdk Inhibition. International Journal of Molecular Sciences, 24 (8), 7009. doi:10.3390/ijms24087009

Burniat, A., Noël, A., Colige, A., Vanderplasschen, A., de Kerchove d'Exaerde, A., Kupper Cardozo, A., Van Keymeulen, A., Moens, A., Bondue, A., Herpain, A., Marchant, A., Loumaye, A., Beck, B., Van den Heyden, B., Corvilain, B., Lakaye, B., Rogister, B., Malgrange, B., Michiels, C., ... Brunko, E. (2023). Cent scientifiques répliquent à SEA (Suppression des Expériences sur l’Animal vivant) et dénoncent sa désinformation. La Libre Belgique.

Chohra, I., Chung, K., Giri, S., & Malgrange, B. (07 February 2023). ATP-Dependent Chromatin Remodellers in Inner Ear Development. Cells, 12 (4). doi:10.3390/cells12040532

Gauthy, C., Penoy, N., Evrard, B., Malgrange, B., & Piel, G. (01 February 2023). Development of a sustained-release form of dexamethasone for the local treatment of sensorineural hearing loss [Poster presentation]. CIRM Day, Liège, Belgium.

Malgrange, B., & Nguyen, L. (09 September 2022). Scaling brain neurogenesis across evolution. Science, 377 (6611), 1155-1156. doi:10.1126/science.ade4388

Dion, V.* , Schumacher, N.* , Masar, N., Pieltain, A., Tocquin, P., LESOINNE, P., Malgrange, B., Vandenbosch, R.* , & Franzen, R.*. (2022). Cyclin-dependent kinase 7 contributes to myelin maintenance in the adult central nervous system and promotes myelin gene expression. Glia. doi:10.1002/glia.24186

Giri, S., & Malgrange, B. (2022). Application of CRISPR/Cas system in iPSC-based disease model of hereditary deafness 9. In A. Birbrair, iPSCs - State of the Science. academic press. doi:10.1016/B978-0-323-85767-3.00009-8

Pouyo, L. R., Chung, K., Delacroix, L., & Malgrange, B. (2021). The ubiquitin-proteasome system in normal hearing and deafness. Hearing Research, 108366. doi:10.1016/j.heares.2021.108366

Renauld, J., Thelen, N., Bartholomé, O., Malgrange, B., & Thiry, M. (2021). Dispensability of tubulin acetylation for 15-protofilament microtubule formation in the mammalian cochlea. Cell Structure and Function. doi:10.1247/csf.20057

DELHEZ, A., LEFEBVRE, P., Pequeux, C., Malgrange, B., & Delacroix, L. (2020). Auditory function and dysfunction:estrogen makes a difference. Cellular and Molecular Life Sciences, 77, 619-635. doi:10.1007/s00018-019-03295-y

Marlier, Q., D'Aes, T., Verteneuil, S., Vandenbosch, R., & Malgrange, B. (2020). Core cell cycle machinery is crucially involved in both life and death of post-mitotic neurons. Cellular and Molecular Life Sciences. doi:10.1007/s00018-020-03548-1

Balthazart, J., Blanpain, C., Bureau, F., Cani, P., Chariot, A., Drion, P., Engel, V., Hanson, J., de Kerchove d'Exaerde, A., Malgrange, B., Muraille, E., Nguyen, L., Servais, O., Seutin, V., & Tissir, F. (2019). L’expérimentation animale : toujours une nécessité pour la santé animale et humaine. Le Soir.

Pouyo, L. R., Thelen, N., Delacroix, L., & Malgrange, B. (13 June 2019). Functions of NEDD4-2 in the auditory portion of the inner ear [Paper presentation]. BSCDB Spring meeting, June 13th, 2019, Liège, Belgium.

Czajkowski, A., Mounier, A., Delacroix, L., & Malgrange, B. (2019). Pluripotent stem cell-derived cochlear cells: a challenge in constant progress. Cellular and Molecular Life Sciences. doi:10.1007/s00018-018-2950-5

Defourny, J., Peuckert, C., Kullander, K., & Malgrange, B. (2019). EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions. iScience, 11, 246-257. doi:10.1016/j.isci.2018.12.017

Even, A., Morelli, G., Broix, L., Scaramuzzino, C., Turchetto, S., Gladwyn-Ng, I., Le Bail, R., Shilian, M., Freeman, S., Magiera, M. M., Jijumon, A. S., Krusy, N., Malgrange, B., Brone, B., Dietrich, P., Dragatsis, I., Janke, C., Saudou, F., Weil, M., & Nguyen, L. (2019). ATAT1-enriched vesicles promote microtubule acetylation via axonal transport. Science Advances, 5 (12), 2705. doi:10.1126/sciadv.aax2705

Freeman, S.* , Mateo Sánchez, S.* , Pouyo, R., Van Lerberghe, P.-B., Hanon, K., Thelen, N., Thiry, M., Morelli, G., Van Hees, L., Laguesse, S., Chariot, A., Nguyen, L., Delacroix, L.* , & Malgrange, B.*. (2019). Proteostasis is essential during cochlear development for neuron survival and hair cell polarity. EMBO Reports, 20 (9). doi:10.15252/embr.201847097

Muraille, E., de kerchove, A., Muylkens, B., Malgrange, B., Nicaise, C., Léna, C., Gueydan, C., Andris, F., Bureau, F., Tissir, F., Gofflot, F., Vassart, G., Balthazart, J., Vandeweerd, J.-M., Bakker, J., Duqué, J., Laurence, R., Nguyen, L., Schetgen, M., ... De Tiège, X. (2018). Expérimentation animale: la recette d'une polémique scientifique. La Libre Belgique.

Bakker, J., Balthazart, J., Baron, F., Beguin, Y., Bettendorff, L., Blanpain, C., Bureau, F., Caers, J., Cani, P., Cataldo, D., Cornil, C., Clercx, C., Cloots, R., Colige, A., Daube, G., De Backer, O., de Kerchove d'Exaerde, A., Desmecht, D., Desmet, C., ... Wittamer, V. (2018). La souris, le patient, et le faux expert. Décryptage d'une mystification. Le Vif. L'Express.

Drion, P., Corhay, A., Haubruge, E., Cloots, R., Rentier, B., Balthazart, J., RADERMECKER, R., Bureau, F., DEFRAIGNE, J., Malgrange, B., Nguyen, L., Desmecht, D., Bakker, J., Vanderplasschen, A., Seutin, V., Noël, A., & Foidart, J.-M. (2018). Analyse détaillée de la seconde version de l’avant-projet de Code du bien-être animal wallon. Lecture commentée au 21/03/2018 du Chapitre 8 (Expérimentation animale). https://orbi.uliege.be/handle/2268/223081

Caron, N.* , Genin, E.* , Marlier, Q., Verteneuil, S., Beukelaers, P., Morel, L., Hu, M., Hinds, P., Nguyen, L., Vandenbosch, R.* , & Malgrange, B.*. (2018). Proliferation of hippocampal progenitors relies on p27-dependent regulation of Cdk6 kinase activity. Cellular and Molecular Life Sciences. doi:10.1007/s00018-018-2832-x

Gomes Da Silva, C., Peyre, E., Adhikari, M. H., Tielens, S., Tanco, S., Van Damme, P., Magno, L., Krusy, N., Agirman, G., Magiera, M. M., Kessaris, N., Malgrange, B., Andrieux, A., Janke, C., & Nguyen, L. (2018). Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis. Cell, 172 (5), 1063-1067.e19. doi:10.1016/j.cell.2018.01.031

Marlier, Q., Jibassia, F., Verteneuil, S., Linden, J., Kaldis, P., Meijer, L., Nguyen, L., Vandenbosch, R.* , & Malgrange, B.*. (2018). Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death. Cell Death Discovery. doi:10.1038/s41420-018-0044-7

DELHEZ, A., Manfroid, I., LEFEBVRE, P., Delacroix, L., & Malgrange, B. (2017). Potential use of estetrol in sensorineural hearing loss protection. B-ENT.

Laguesse, S., Close, P., Van Hees, L., Chariot, A., Malgrange, B., & Nguyen, L. (2017). Loss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex. Frontiers in Cellular Neuroscience, 11, 122. doi:10.3389/fncel.2017.00122

Freeman, S., Mateo Sanchez, S., Delacroix, L., & Malgrange, B. (18 May 2016). Disruption of the lysine acetyltransferase Elp3 causes planar polarity defects in the mouse organ of Corti [Poster presentation]. 10th Molecular Biology of Hearing and Deafness Conference.

Czajkowski, A., Grobarczyk, B., Hanon, K., LEFEBVRE, P., Delacroix, L., & Malgrange, B. (May 2016). Derivation of cochlear cells from pathological or isogenic human iPSCs for modeling hereditary hearing loss [Poster presentation]. 10th Molecular Biology of Hearing and Deafness conference, Hinxton, United Kingdom.

Borgs, L.* , Peyre, E.* , Alix, P., Hanon, K., Grobarczyk, B., Godin, J., Purnelle, A., Krusy, N., Maquet, P., Lefèbvre, P., Seutin, V., Malgrange, B.* , & Nguyen, L.*. (2016). Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects. Scientific Reports, 6, 33377. doi:10.1038/srep33377

Mateo Sanchez, S., Freeman, S., Delacroix, L., & Malgrange, B. (2016). The Role of Post-Translational Modifications in Hearing and Deafness. Cellular and Molecular Life Sciences. doi:10.1007/s00018-016-2257-3

Czajkowski, A., Chariot, A. (Other coll.), Delacroix, L. (Other coll.), & Malgrange, B. (Other coll.). (29 May 2015). Unravelling Cemip expression and functions in the auditory portion of the inner ear [Poster presentation]. BSCDB - BELGIAN SOCIETY FOR CELL AND DEVELOPMENTAL BIOLOGY.

Defourny, J., Mateo Sanchez, S., Schoonaert, L., Robberecht, W., Davy, A., Nguyen, L., & Malgrange, B. (2015). Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling. Nature Communications. doi:10.1038/ncomms8017

Huyghe, A.* , Van Den Ackerveken, P.* , SACHELI, R., Prevot, P.-P., Thelen, N., Renauld, J., Thiry, M., Delacroix, L., Nguyen, L., & Malgrange, B. (2015). MicroRNA-124 Regulates Cell Specification in the Cochlea through Modulation of Sfrp4/5. Cell Reports, 13, 31-42. doi:10.1016/j.celrep.2015.08.054

Malgrange, B., Varela-Nieto, I., de Medina, P., & Paillasse, M. R. (2015). Targeting cholesterol homeostasis to fight hearing loss: a new perspective. Frontiers in Aging Neuroscience, 7, 3. doi:10.3389/fnagi.2015.00003

Marlier, Q., Verteneuil, S., Vandenbosch, R., & Malgrange, B. (2015). Mechanisms and Functional Significance of Stroke-Induced Neurogenesis. Frontiers in Neuroscience. doi:10.3389/fnins.2015.00458

Volvert, M.-L., Prevot, P.-P., Close, P., Laguesse, S., Pirotte, S., Hemphill, J., Rogister, F., Krusy, N., SACHELI, R., MOONEN, G., Deiters, A., Merkenschlager, M., CHARIOT, A., Malgrange, B., Godin, J., & Nguyen, L. (May 2014). MicroRNA Targeting of CoREST controls polarization of migrating cortical neurons. Cell Reports, 7 (4), 1168-83. doi:10.1016/j.celrep.2014.03.075

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (31 May 2013). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. BSN Congress.

Defourny, J., Poirrier, A.-L., Lallemend, F., Mateo Sanchez, S., Neef, J., Vanderhaeghen, P., Soriano, E., Peuckert, C., Kullander, K., Fritzsch, B., Nguyen, L., Moonen, G., Moser, T., & Malgrange, B. (2013). Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells. Nature Communications, 4, 1438. doi:10.1038/ncomms2445

POIRRIER, A.-L., Van Den Ackerveken, P., Defourny, J., LEFEBVRE, P., & Malgrange, B. (2013). In vivo protection of spiral ganglion neurons by bryostatin 1: preliminary results. Advances in Cellular and Molecular Otolaryngology, 1.

Vandenbosch, R., Chocholova, E., Robe, P., Wang, Y., Lambert, C., Moonen, G., Lallemend, F., Malgrange, B., & Hadjab, S. (2013). A role for the canonical nuclear factor-κB pathway in coupling neurotrophin-induced differential survival of developing spiral ganglion neurons. Frontiers in Cellular Neuroscience, 7, 1-10. doi:10.3389/fncel.2013.00242

Beukelaers, P.* , Vandenbosch, R.* , Caron, N., Nguyen, L., Moonen, G., & Malgrange, B. (2012). Cycling or not cycling: cell cycle regulatory molecules and adult neurogenesis. Cellular and Molecular Life Sciences, 69 (9), 1493-1503. doi:10.1007/s00018-011-0880-6

Lerinckx, D., Baguet, M., Renaville, F., de Bergeyck, V., Luminet, O., Kita, J.-C., Malgrange, B., Ponthot, J.-P., Schneider, N., Corbisier, F., Vanclef, L., Raes, M., Verhasselt, J.-M., Hubert, M., Culot, C., Tenenbaum, A., Gérard, M., & Renaville, F. (Ed.). (2011). Comparaison des outils bibliographiques et bibliométriques Web of Science et Scopus : rapport du groupe de réflexion mis en place par la Bibliothèque Interuniversitaire de la Communauté française de Belgique (BICfB). https://orbi.uliege.be/handle/2268/94948

Johnen, N., Thelen, N., Cloes, M., Malgrange, B., & Thiry, M. (31 March 2011). Spatio-temporal localization of the cytoskeleton during auditory organ development in mammalia [Poster presentation]. Cellular cytoskeletal motor proteins, Cambridge, Hinxton, United Kingdom.

Thelen, N., Cloes, M., Johnen, N., Compère, P., Malgrange, B., & Thiry, M. (31 January 2011). Distribution of glycogen during the development of the organ of Corti [Poster presentation]. GIGA-Day, Liège, Belgium.

Malgrange, B., Borgs, L., Grobarczyk, B., Purnelle, A., Ernst, P., Moonen, G., & Nguyen, L. (2011). Using human pluripotent stem cells to untangle neurodegenerative disease mechanisms. Cellular and Molecular Life Sciences, 68 (4), 635-49. doi:10.1007/s00018-010-0557-6

Johnen, N., Thelen, N., Malgrange, B., & Thiry, M. (17 October 2009). SPATIO-TEMPORAL LOCALIZATION OF INTERMEDIATE FILAMENTS IN THE ORGAN OF CORTI BETWEEN THE EMBRYONIC DAY 18 (E18) AND THE POST-NATAL DAY 15 (P15) IN RAT [Poster presentation]. Protein Modifications in Devellopmental Signalling and Disease, Liège, Belgium.

Johnen, N., Thelen, N., Malgrange, B., & Thiry, M. (11 May 2009). Supporting cell cytoskeleton during development of the organ of Corti in rat [Poster presentation]. The 8th bi-annual meeting of the Belgian Society for Neuroscience, Liège, Belgium.

Borgs, L., Beukelaers, P., Vandenbosch, R., Nguyen, L., Moonen, G., Maquet, P., Albrecht, U., Belachew, S., & Malgrange, B. (2009). Period 2 regulates neural stem/progenitor cell proliferation in the adult hippocampus. BMC Neuroscience, 10, 30. doi:10.1186/1471-2202-10-30

Thelen, N., Compère, P., Malgrange, B., & Thiry, M. (2009). Spatiotemporal distribution of glycogen during the mammalian auditory organ development [Poster presentation]. 8th Bi-Annual Meeting of Begian Society for Neuroscience, Liège, Belgium.

Thelen, N., Malgrange, B., & Thiry, M. (2007). The inner pillar cells: an unusual cell type of the auditory organ during neonatal development [Poster presentation]. 14th Benelux Congress of Zoology, Amsterdam, Netherlands.

Banfi, B., Malgrange, B., Knisz, J., Steger, K., Dubois-Dauphin, M., & Krause, K.-H. (29 October 2004). NOX3, a superoxide-generating NADPH oxidase of the inner ear. Journal of Biological Chemistry, 279 (44), 46065-46072. doi:10.1074/jbc.M403046200

Van De Water, T. R., Lallemend, F., Eshraghi, A. A., Ahsan, S., He, J., Guzman, J., Polak, M., Malgrange, B., Lefèbvre, P., Staecker, H., & Balkany, T. J. (July 2004). Caspases, the enemy within, and their role in oxidative stress-induced apoptosis of inner ear sensory cells. Otology and Neurotology, 25 (4), 627-632. doi:10.1097/00129492-200407000-00035

Nguyen, L., Malgrange, B., Breuskin, I., Bettendorff, L., Moonen, G., Belachew, S., & Rigo, J.-M. (2003). Autocrine/paracrine activation of the GABA(A) receptor inhibits the proliferation of neurogenic polysialylated neural cell adhesion molecule-positive (PSA-NCAM+) precursor cells from postnatal striatum. Journal of Neuroscience, 23 (8), 3278-94. doi:10.1523/jneurosci.23-08-03278.2003

Malgrange, B., Thiry, M., Van De Water, T. R., Nguyen, L., Moonen, G., & Lefebvre, P. (October 2002). Epithelial supporting cells can differentiate into outer hair cells and Deiters' cells in the cultured organ of Corti. Cellular and Molecular Life Sciences, 59 (10), 1744-1757. doi:10.1007/PL00012502

Martens, H., Malgrange, B., Robert, F., Charlet, C., De Groote, D., Heymann, D., Godard, A., Soulillou, J. P., Moonen, G., & Geenen, V. (14 November 1996). Cytokine Production by Human Thymic Epithelial Cells: Control by the Immune Recognition of the Neurohypophysial Self-Antigen. Regulatory Peptides, 67 (1), 39-45. doi:10.1016/S0167-0115(96)00105-X