Publications and communications of Pascal De Tullio

Coelho Cristino Mamede, L. C., Fall, F., Schoumacher, M., Ledoux, A., Bugli, C., De Tullio, P., Quetin-Leclercq, J., Govaerts, B., & Frederich, M. (February 2024). Comparison of extraction methods in vitro Plasmodium falciparum: A 1 H NMR and LC-MS joined approach. Biochemical and Biophysical Research Communications, 703, 149684. doi:10.1016/j.bbrc.2024.149684

Cirillo, A., Résimont, G., Jouret, F., Vidal-Petiot, E., Flamant, M., Delanaye, P., & De Tullio, P. (31 January 2024). How can metabolomics help the follow-up management of kidney transplantation recipients? An untargeted based-metabolomics multiplatform study [Paper presentation]. Metabolomics in Life Science, Umea, Sweden.

Francotte, P., Bay, Y., Goffin, E., Colson, T., Lesenfants, C., Dorosz, J., Laulumaa, S., Fraikin, P., De Tullio, P., Beaufour, C., Botez, I., Pickering, D., Frydenvang, K., Danober, L., Skov Kristensen, A., Sandholm Kastrup, J., & Pirotte, B. (09 December 2023). Exploring thienothiadiazine dioxides as isosteric analogues of benzo-and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. European Journal of Medicinal Chemistry, 264, 116036. doi:10.1016/j.ejmech.2023.116036

Iovino, M., Colonval, M., Wilkin, C., L'Homme, L., Lassence, C., Campas, M., Peulen, O., De Tullio, P., Piette, J., & Legrand, S. (2023). Novel XBP1s-independent function of IRE1 RNase in HIF-1α-mediated glycolysis upregulation in human macrophages upon stimulation with LPS or saturated fatty acid. Frontiers in Immunology. doi:10.3389/fimmu.2023.1204126

Cirillo, A., Vandermeulen, M., Erpicum, P., Pinto Coelho, T., MEURISSE, N., Detry, O., Jouret, F., & De Tullio, P. (18 June 2023). Untargeted 1H NMR-based analysis of kidney allograft perfusates identifies a metabolomics signature of delayed graft function [Poster presentation]. Metabolomics Society, Niagara Falls, Canada.

Cirillo, A., Leenders, J., Squatrito, M., Celine Bugli, Bernadette Govaerts, Michèle Nisolle, Munaut, C., & De Tullio, P. (February 2023). Metabiose project: an endometriosis predictive signature through metabolomics [Paper presentation]. CIRM day.

Arslan, D., Schoumacher, M., Dilly, S., Elmoualij, B., Zorzi, D., Quatresooz, P., Lambert, V., Noël, A., Pirotte, B., & De Tullio, P. (2023). Design, Synthesis, and Evaluation of Novel Pyruvate Dehydrogenase Kinase Inhibitors. Medicinal Chemistry, 19 (3), 276-296. doi:10.2174/1573406418666220819102627

Coelho Cristino Mamede, L. C., Fall, F., Schoumacher, M., Ledoux, A., De Tullio, P., Quetin-Leclercq, J., & Frederich, M. (2022). Recent metabolomic developments for antimalarial drug discovery. Parasitology Research. doi:10.1007/s00436-022-07673-7

Rademaker, G.* , Boumahd, Y.* , Peiffer, R., Anania, S., Wissocq, T., Liégeois, M., Luis, G., Sounni, N. E., Agirman, F., Maloujahmoum, N., De Tullio, P., Thiry, M., Bellahcene, A., Castronovo, V., & Peulen, O. (July 2022). Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells. Redox Biology, 53, 102324. doi:10.1016/j.redox.2022.102324

Cirillo, A., Résimont, G., Delanaye, P., Emmanuelle Vidal-Petiot, Martin Flamant, Jouret, F., & De Tullio, P. (19 June 2022). Application of metabolomics to the evaluation of kidney function and kidney transplantation [Poster presentation]. Metabolomics Society.

Fall, F., Coelho Cristino Mamede, L. C., Schioppa, L., Ledoux, A., De Tullio, P., Michels, P., Frederich, M., & Quetin-Leclercq, J. (19 March 2022). Trypanosoma brucei: Metabolomics for analysis of cellular metabolism and drug discovery. Metabolomics, 18 (4), 20. doi:10.1007/s11306-022-01880-0

Coelho Cristino Mamede, L. C., Schoumacher, M., Cirillo, A., Fall, F., Bugli, C., Ledoux, A., De Tullio, P., Quetin-Leclercq, J., Govaerts, B., & Frederich, M. (02 February 2022). Exploration of untargeted metabolomic extraction methods of in vitro malaria samples by 1H NMR analysis - follow up [Poster presentation]. CIRM Day, Liège, Belgium.

Cirillo, A.* , Schoumacher, M.* , De Tullio, P.* , Campas, M. (Other coll.), & Gauthy, C. (Other coll.). (2022). Dried blood spot sampling: a new tool for NMR-based metabolomics approach [Poster presentation]. Analystics.

Schoumacher, M., Lambert, V., Govaerts Bernadette, Rakic, J.-M., Noël, A., & De Tullio, P. (2022). From cohort study to the “real life” in patient’s follow-up and personalized medicine using NMR- based clinical metabolomics; results, issues, problems and prospects: the case of neovascular Age-related Macular Degeneration (nAMD) [Poster presentation]. Metabolomics 2022 Valence, valence, Spain.

Coelho Cristino Mamede, L. C., Schoumacher, M., Cirillo, A., Fall, F., Bugli, C., Ledoux, A., De Tullio, P., Quetin-Leclercq, J., Govaerts, B., & Frederich, M. (November 2021). Exploration of untargeted metabolomic extraction methods for in vitro malaria samples by 1H NMR analysis [Poster presentation]. 14èmes Journées Scientifiques du Réseau Francophone de Métabolomique et Fluxomique, Aussois, France.

Cirillo, A., Huart, J., Taminiau, B., Descy, J., Saint-Remy, A., Daube, G., KRZESINSKI, J.-M., MELIN, P., JOURET, F., & De Tullio, P. (26 May 2021). Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study [Poster presentation]. CIRM day.

HUART, J.* , Cirillo, A.* , Taminiau, B., DESCY, J., SAINT-REMY, A., Daube, G., KRZESINSKI, J.-M., MELIN, P., De Tullio, P.* , & JOURET, F.*. (29 April 2021). Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study. Metabolites, 11 (5), 282. doi:10.3390/metabo11050282

HUART, J.* , Cirillo, A.* , SAINT-REMY, A., KRZESINSKI, J.-M., De Tullio, P.* , & Jouret, F.*. (2021). The faecal abundance of short chain fatty acids is increased in men with a non-dipping blood pressure profile. Acta Cardiologica. doi:10.1080/00015385.2021.1901020

Ledoux, A., Coelho Cristino Mamede, L. C., Palazzo, C., Furst, T., Jansen, O., De Tullio, P., Kagisha, V., Pendeville-Samain, H., Fillet, M., Piel, G., & Frederich, M. (18 May 2020). Heparin-Coated Liposomes Improve Antiplasmodial Activity and Reduce the Toxicity of Poupartone B. Planta Medica International Open, 7 (e), 73–80. doi:10.1055/a-1158-0569

Bayiha, J. C., Evrard, B., Cataldo, D., De Tullio, P., & Mingeot-Leclercq, M.-P. (2020). The Budesonide-Hydroxypropyl-β-Cyclodextrin Complex Attenuates ROS Generation, IL-8 Release and Cell Death Induced by Oxidant and Inflammatory Stress. Study on A549 and A-THP-1 Cells. Molecules, 25, 4882. doi:10.3390/molecules25214882

Cirillo, A., Schoumacher, M. (Other coll.), & De Tullio, P. (Other coll.). (11 December 2019). Study of dried blood spots sampling for NMR based metabolomics [Poster presentation]. CIRM day.

Costanza, B., Rademaker, G., Tiamiou, A., De Tullio, P., Leenders, J., Blomme, A., Bellier, J., Bianchi, E., Turtoi, A., Delvenne, P., Bellahcene, A., Peulen, O.* , & Castronovo, V.*. (2019). TGFBI, an ECM interacting protein, enhances glycolysis and promotes pancreatic cancer cell migration. International Journal of Cancer. doi:10.1002/ijc.32247

HUART, J., Leenders, J., Taminiau, B., DESCY, J., SAINT-REMY, A., Daube, G., KRZESINSKI, J.-M., MELIN, P., De Tullio, P., & JOURET, F. (18 May 2018). GUT MICROBIOTA AND FAECAL LEVELS OF SHORT CHAIN FATTY ACIDS DIFFER UPON BLOOD PRESSURE LEVELS IN MAN. Nephrology Dialysis Transplantation, 33 (Issue suppl_1), 368–i369. doi:10.1093/ndt/gfy104.SP069

Cauchie, E., Korsak Koulagenko, N., Leenders, J., Baré, G., Tahiri, A., Delhalle, L., De Tullio, P., & Daube, G. (2018). A NMR-based metabolomics approach for reducing food losses: the example of minced pork meat. In Proceedings of the First international Conference on "Innovative Food Ingredients and Food safety" (pp. 89-99). Bangkok, Thailand: Asian Institute of Technology.

Yakulov, T. A., Todkar, A. P., Slanchev, K., Wiegel, J., Bona, A., Gross, M., Scholz, A., Hess, I., Wurditsch, A., Grahammer, F., Huber, T. B., Lecaudey, V., Bork, T., Hochrein, J., Boerries, M., Leenders, J., De Tullio, P., Jouret, F., Kramer-Zucker, A., & Walz, G. (2018). CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury. Nature Communications, 9 (1), 3660. doi:10.1038/s41467-018-06094-4

Cauchie, E., Leenders, J., Baré, G., Tahiri, A., Delhalle, L., Korsak Koulagenko, N., De Tullio, P., & Daube, G. (13 October 2017). A NMR-based metabolomics study of minced pork meat inoculated with Brochothrix thermosphacta, Leuconostoc gelidum and Pseudomonas fragi [Poster presentation]. FARAH Day 2017, Liège, Belgium.

Schnekenburger, M., Goffin, E., Lee, J.-Y., Jang, J. Y., Mazumder, A., Ji, S., Rogister, B., Bouider, N., Lefranc, F., Miklos, W., Mathieu, V., De Tullio, P., Kim, K.-W., Dicato, M., Berger, W., Han, B., Kiss, R., Pirotte, B., & Diederich, M. (08 June 2017). Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. Journal of Medicinal Chemistry, 60 (11), 4714-4733. doi:10.1021/acs.jmedchem.7b00533

Bigazzi, W., Dufour, G., De Tullio, P., Piel, G., Cataldo, D., & Evrard, B. (June 2017). Interest of cylodextrins in spray-dried microparticles formulation for sustained pulmonary delivery of budesonide [Poster presentation]. EuroDrying’2017 – 6th European Drying Conference, Liège, Belgium.

Hendrick, E., Peixoto, P., Blomme, A., Polese, C., Matheus, N., Cimino, J., Frère, A., Mouithys-Mickalad, A., Serteyn, D., Bettendorff, L., Elmoualij, B., De Tullio, P., Eppe, G., Dequiedt, F., Castronovo, V., & Mottet, D. (2017). Metabolic inhibitors accentuate the anti-tumoral effect of HDAC5 inhibition. Oncogene. doi:10.1038/onc.2017.103

Nokin, M.-J., Durieux, F., Peixoto, P., Chiavarina, B., Peulen, O., Blomme, A., Turtoi, A., Costanza, B., Smargiasso, N., Baiwir, D., Scheijen, J., Schalkwijk, C., Leenders, J., De Tullio, P., BIANCHI, E., Thiry, M., Uchida, K., Spiegel, D., Cochrane, J., ... Bellahcene, A. (2016). Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP- mediated tumor growth and metastasis. eLife. doi:10.7554/eLife.19375

Jouret, F., Leenders, J., Defraigne, J.-O., Krzesinski, J.-M., & De Tullio, P. (22 September 2016). Nuclear Magnetic Resonance Metabolomic Profiling of Mouse Kidney, Urine and Serum Following Renal Ischemia/Reperfusion Injury. PLoS ONE, 11 (9), 1-14. doi:10.1371/journal.pone.0163021

Baré, G., Cauchie, E., Leenders, J., Tahiri, A., Delhalle, L., Korsak Koulagenko, N., De Tullio, P., & Daube, G. (July 2016). Challenge testing with Brochothrix thermosphacta on minced pork meat shows interest to couple metagenetics to metabolomics to study food spoilage [Poster presentation]. 17th European Congress on Biotechnology, Cracovie, Poland.

Habyalimana, V., Mbinze Kindenge, J., Kalenda Tshilombo, N., Dispas, A., Yemoa Loconon, A., Sacre, P.-Y., Widart, J., De Tullio, P., Counerotte, S., Kadima Ntokamunda, J.-L., Ziemons, E., Hubert, P., & Marini Djang'Eing'A, R. (02 December 2015). Analytical Tools and Strategic Approach to Detect Poor Quality Medicines, Identify Unknown Components, and Timely Alerts for Appropriate Measures: Case Study of Antimalarial Medicines. American Journal of Analytical Chemistry, 6, 977-994. doi:10.4236/ajac.2015.613093

Martin, B., Frederich, M., De Tullio, P., Tits, M., Wauters, J.-N., Choi, & Bodson, M. (June 2015). Metabolomics analysis of Galium odoratum (L.) Scop.: impact of the plant population origin and growth conditions. Current Metabolomics, 3.

Bentaib, A., De Tullio, P., Chneiweiss, H., Hermans, E., Junier, M.-P., & Leprince, P. (March 2015). Data in support of metabolic reprogramming in transformed mouse cortical astrocytes: A proteomic study. Data in Brief, 2 (0), 1-5. doi:10.1016/j.dib.2014.09.004

Blomme, A., Costanza, B., Thiry, M., De Tullio, P., Perez-Palacios, A., Mouithys-Mickalad, A., LIFRANGE, E., Delvenne, P., Castronovo, V., & Turtoi, A. (31 January 2015). Myoferlin Regulates Endosomal Trafficking and Tunes Cancer Cell Metabolism [Poster presentation]. ASSOCIATION BELGE POUR L'ETUDE DU CANCER "A.B.E.C» ANNUAL MEETING 2015: TUMOR METABOLISM AND MITOCHONDRIA, Louvain, Belgium.

WEEKERS, L., De Tullio, P., BOVY, C., Poma, L., Marée, R., BONVOISIN, C., Defraigne, J.-O., Krzesinski, J.-M., & Jouret, F. (30 January 2015). Activation of the calcium-sensing receptor before renal ischemia/reperfusion exacerbates kidney injury. American Journal of Translational Research, 7 (1), 128-138.

Blomme, A., Costanza, B., Thiry, M., De Tullio, P., Perez Palacios, A., LIFRANGE, E., DELVENNE, P., Castronovo, V., & Turtoi, A. (27 January 2015). Myoferlin regulates endosomal trafficking and tunes cancer cell metabolism [Poster presentation]. GIGA-DAY 2015: Current advances in medical genetics and genomics, Liège, Belgium.

Nokin, M.-J., Durieux, F., Peixoto, P., Chiavarina, B., Smargiasso, N., Baiwir, D., De Pauw, E., De Tullio, P., Thiry, M., Peulen, O., Turtoi, A., Castronovo, V., & Bellahcene, A. (27 January 2015). Accumulation of methylglyoxal, a glycolysis by-product modulates YAP1 transcription co-factor localization and activity in human breast cancer cells through HSP90 modification [Poster presentation]. GIGA-DAY: Current advances in medical genetics and genomics, Liège, Belgium.

Dufour, G., Evrard, B., & De Tullio, P. (2015). Rapid quantification of 2-hydroxypropyl-β-cyclodextrin in liquid pharmaceutical formulations by 1H nuclear magnetic resonance spectroscopy. European Journal of Pharmaceutical Sciences. doi:10.1016/j.ejps.2015.03.005

Arslan, D., Pirotte, B., De Tullio, P., Charif, M. (Other coll.), Dilly, S. (Other coll.), Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (09 September 2014). AGE-RELATED MACULAR DEGENERATION (AMD): FROM METABOLOMICS APPROACH TO THE INHIBITION OF PDK AS A NEW THERAPEUTIC TARGET [Poster presentation]. XXIII International Symposium on Medicinal Chemistry (EFMC-ISMC 2014), Lisbonne, Portugal.

Ponthier, J., De Tullio, P., Parrilla Hernandez, S., Blommaert, D., GASPARD, O., & Deleuze, S. (September 2014). Glucose use and lactate production by equine fresh semen in human and equine extender. Reproduction in Domestic Animals, 49 (suppl 3), 13.

Ponthier, J., De Tullio, P., Blommaert, D., Parrilla Hernandez, S., & Deleuze, S. (January 2014). Sperm Motility and Lactate production at different sperm concentrations. Journal of Equine Veterinary Science, 34 (1), 75-76.

LAMBERT, V., Lecomte, J., Hansen, S., Blacher, S., Alvarez Gonzalez, M.-L., Struman, I., Sounni, N. E., Rozet, E., De Tullio, P., Foidart, J.-M., Rakic, J.-M., & Noël, A. (2013). Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice. Nature Protocols, 8 (11), 2197-2211. doi:10.1038/nprot.2013.135

Goffin, E., Lamoral-Theys, D., Tajeddine, N., De Tullio, P., Mondin, L., Lefranc, F., Gailly, P., ROGISTER, B., Kiss, R., & Pirotte, B. (2012). N-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis. European Journal of Medicinal Chemistry, 54, 834-44. doi:10.1016/j.ejmech.2012.06.050

Hemmer, M., Kempen, I., De Tullio, P., Frankenne, F., Lambert, V., Blacher, S., Bueb, J.-L., Foidart, J.-M., Noël, A., Tschirhart, E., & Pirotte, B. (2010). New Biological Investigations on 3-Bromophenyl 6-Acetoxymethyl-2-oxo-2H-1-Benzopyran-3-Carboxylate as Anti-angiogenic Agent. Drug Development Research, 71, 1-10. doi:10.1002/ddr.20364

Kempen, I., Hemmer, M., Counerotte, S., Pochet, L., De Tullio, P., Foidart, J.-M., Blacher, S., Noël, A., Frankenne, F., & Pirotte, B. (December 2008). 6-Substituted 2-Oxo-2h-1-Benzopyran-3-Carboxylic Acid Derivatives in a New Approach of the Treatment of Cancer Cell Invasion and Metastasis. European Journal of Medicinal Chemistry, 43 (12), 2735-50. doi:10.1016/j.ejmech.2008.01.024

De Tullio, P. (2007). Le noyau arylthiadiazine 1,1-dioxyde en chimie médicinale : développements originaux de composés à potentialités thérapeutiques [Post doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/63196

Martin, G., Chiap, P., Paquet, P., Pierard, G., De Tullio, P., Martin, Y., Rozet, E., Hubert, P., Crommen, J., & Fillet, M. (2007). Development of a mass spectrometry method for the determination of a melanoma biomarker, 5-S-cysteinyldopa, in human plasma using solid phase extraction for sample clean-up. Journal of Chromatography. A, 1156 (1-2), 141-8. doi:10.1016/j.chroma.2006.12.088

Lee, A. T., Cosgrove, K. E., Barnes, P. D., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic b-cells. Endocrine abstracts 2002, 16.