Publications and communications of Luc Willems

Suárez Archilla, G., Gutiérrez, G., Camussone, C., Calvinho, L., Abdala, A., Alvarez, I., Petersen, M., Franco, L., Destefano, G., Monti, G., Jacques, J.-R., Joris, T., Willems, L.* , & Trono, K.*. (10 August 2022). A safe and effective vaccine against bovine leukemia virus. Frontiers in Immunology, 13. doi:10.3389/fimmu.2022.980514
* These authors have contributed equally to this work.

Hoyos, C.* , Fontaine, A.* , Jacques, J.-R., HEINEN, V., LOUIS, R., DUYSINX, B., Scherpereel, A., Wasielewski, E., Jamakhani, M.* , Hamaïdia, M.* , & Willems, L.*. (26 April 2022). HDAC Inhibition with Valproate Improves Direct Cytotoxicity of Monocytes against Mesothelioma Tumor Cells. Cancers, 14 (9), 2164. doi:10.3390/cancers14092164
* These authors have contributed equally to this work.

Li, Y., Yang, S., Huang, X., Yang, N., Wang, C., Zhao, J., Jing, Z., Willems, L., & Liu, G. (24 December 2021). MyD88 Mediates Colitis- and RANKL-Induced Microfold Cell Differentiation. Veterinary Sciences, 9. doi:10.3390/vetsci9010006

Hoyos, C., Fontaine, A., Brossel, H., Willems, M., Jamakhani, M., Vandermeers, F., Safari, R., HEINEN, V., LOUIS, R., DUYSINX, B., Scherpereel, A., Wasielewski, E., Mascaux, C., Hamaïdia, M.* , & Willems, L.*. (14 December 2021). Contribution of lysine deacetylases to the therapy of malignant pleural mesothelioma. Poster session presented at Giga Cancer Day, Liège, Belgium.
* These authors have contributed equally to this work.

Joris, T., Jacques, J.-R., Gouverneur, L., Hamaïdia, M., Jamakhani, M., Lin Li, & Willems, L. (14 December 2021). Bovine Leukemia Virus antisense transcription regulates viral replication, affects gene expression and directs host cell fate. Poster session presented at GIGA Cancer Day, Liège, Belgium.

Brossel, H., Fontaine, A., Hoyos, C., Jamakhani, M., Willems, M., Hamaïdia, M., & Willems, L. (27 June 2021). Activation of DNA Damage Tolerance Pathways May Improve Immunotherapy of Mesothelioma. Cancers, 13, 3211. doi:10.3390/cancers13133211

Pluta, A., Blazhko, N. V., Ngirande, C., Joris, T., Willems, L., & Kuźmak, J. (20 February 2021). Analysis of Nucleotide Sequence of Tax, miRNA and LTR of Bovine Leukemia Virus in Cattle with Different Levels of Persistent Lymphocytosis in Russia. Pathogens, 10, 246. doi:10.3390/pathogens10020246

Willems, M., & Willems, L. (20 November 2020). Eosinophils inhibit mesothelioma chemotherapy. Paper presented at GIGA-Cancer Seminars, Liège, Belgium.

Gazon, H., Singh Chauhan, P., Porquet, F., Brunsting Hoffmann, G., Accolla, R., & Willems, L. (10 November 2020). Epigenetic silencing of HTLV-1 expression by the HBZ RNA through interference with the basal transcription machinery. Blood Advances, 4 (21), 5574-5579. doi:10.1182/bloodadvances.2020001675

Hu, X., Xing, Y., Ren, L., Wang, Y., Li, Q., Yang, Q., Du, M., Xu, L., Willems, L., Li, J., & Zhang, L. (20 October 2020). bta-miR-23a Regulates the Myogenic Differentiation of Fetal Bovine Skeletal Muscle-Derived Progenitor Cells by Targeting MDFIC Gene. Genes, 20, 1232. doi:10.3390/genes11101232

Pluta, A., Willems, L., Douville, R. N., & Kuzmak, J. (13 October 2020). Effects of Naturally Occurring Mutations in Bovine Leukemia Virus 50 -LTR and Tax Gene on Viral Transcriptional Activity. Pathogens, 9 (10), 836. doi:10.3390/pathogens9100836

Joris, T., Safari, R., Jacques, J.-R., & Willems, L. (2020). Bovine Leukemia Virus (Retroviridae). In D. Bamford (Ed.) & M. Zuckerman (Crit. Ed.), Encyclopedia of Virology (pp. 144-152). Elsevier. doi:10.1016/B978-0-12-814515-9.00059-X

dos Santos, D. F., Bairros de Pilger, D. R., Vandermeulen, C., Khouri, R., Pedersoli Mantoani, S., Gonçalves Nunes, P. S., de Andrade, P., Carvalho, I., Casseb, J., Twizere, J.-C., Willems, L., Freitas-Junior, L., & Kashima, S. (08 September 2020). Non-cytotoxic 1,2,3-triazole tethered fused heterocyclic ring derivatives display Tax protein inhibition and impair HTLV-1 infected cells. Bioorganic and Medicinal Chemistry, 28, 115746. doi:10.1016/j.bmc.2020.115746

Staumont, B., Jamakhani, M., Costa, C., Vandermeers, F., Sriramareddy, S. N., Redouté, G., Mascaux, C., Delvenne, P., Hubert, P., Safari, R., & Willems, L. (06 June 2020). TGFα Promotes Chemoresistance of Malignant Pleural Mesothelioma. Cancers, 12 (6), 1484. doi:10.3390/cancers12061484

Safari, R., Jacques, J.-R., Brostaux, Y., & Willems, L. (2020). Ablation of non-coding RNAs affects bovine leukemia virus B lymphocyte proliferation and abrogates oncogenesis. PLoS Pathogens, 16. doi:10.1371/journal.ppat.1008502

Sheynkman, G. M., Tuttle, K. S., Laval, F., Tseng, E., Underwood, J. G., Yu, L., Dong, D., Smith, M. L., Sebra, R., Willems, L., Hao, T., Calderwood, M. A., Hill, D. E., & Vidal, M. (2020). ORF Capture-Seq as a versatile method for targeted identification of full-length isoforms. Nature Communications, 11 (1). doi:10.1038/s41467-020-16174-z

Hoyos, C., Hamaïdia, M., Safari, R., & Willems, L. (28 November 2019). Les monocytes possèdent une activité cytotoxique directe envers les cellules de mésothéliome pleural malin. Poster session presented at 2n des Journées Francophones du Mésothéliome (Nantes), Nantes, France.

Brossel, H., Vikas, Y., & Willems, L. (November 2019). Régulation ubiquitine-dépendante des voies de tolérance aux dommages à l’ADN dans le cadre du mésothéliome pleural malin. Poster session presented at 2èmes journées francophones sur le mésothéliome, Nantes, France.

Brossel, H., Vikas, Y., & Willems, L. (November 2019). Régulation des voies de tolérance aux dommages à l’ADN par la E3 ubiquitine ligase RAD18: Mécanismes et perspectives thérapeutiques dans le cadre du mésothéliome pleural malin. Paper presented at 2èmes journées francophones sur le mésothéliome, Nantes, France.

Willems, M., Willems, L., & Hamaïdia, M. (November 2019). Influence des éosinophiles sur la réponse des cellules de mésothéliome pleural malin à la chimiothérapie. Poster session presented at 2èmes Journées Francophones sur le Mésothéliome, Nantes, France.

Willems, M., Willems, L., & Hamaïdia, M. (November 2019). Influence des éosinophiles sur la réponse des cellules de mésothéliome pleural malin à la chimiothérapie. Paper presented at 2ème Journées Francophones sur le Mésothéliome, Nantes, France.

Hu, X., Xing, Y., Ren, L., Wang, Y., Li, Q., Fu, X., Yang, Q., Xu, L., Willems, L., Li, J., & Zhang, L. (2019). Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B. Animals. doi:10.3390/ani9110859

Abdala, A., Alvarez, I., Brossel, H., Calvinho, L., Carignano, H., Franco, L., Gazon, H., Gillissen, C., Hamaïdia, M., Hoyos, C., Jacques, J.-R., Joris, T., Laval, F., Petersen, M., Porquet, F., Porta, N., Ruiz, V., Safari, R., Suárez Archilla, G., ... Willems, L. (07 October 2019). BLV: lessons on vaccine development. Retrovirology, 2019 (16), 26. doi:10.1186/s12977-019-0488-8

Vassaux, A., Tarayre, C., Arguelles Arias, A., Compère, P., Delvigne, F., Fickers, P., Jahn, L., Lang, A., Leclère, V., Ludwig-Müller, J., Ongena, M., Schafhauser, T., Telek, S., Théatre, A., van Berkel, W., Vandenbol, M., van Pée, K.-H., Willems, L., Wohlleben, W., & Jacques, P. (2019). Astin C production by the endophytic fungus Cyanodermella asteris in planktonic and immobilized culture conditions. Biotechnology Journal. doi:10.1002/biot.201800624

Hamaïdia, M., Gazon, H., Hoyos, C., Hoffmann, G. B., Louis, R., DUYSINX, B., & Willems, L. (2019). Inhibition of EZH2 methyltransferase decreases immunoediting of mesothelioma cells by autologous macrophages through a PD-1-dependent mechanism. JCI Insight, 4 (18). doi:10.1172/jci.insight.128474

Xiukun, S., Xiaoyu, G., Hong, J., Xixi, W., Weidong, L., Ming, L., Xintao, G., Jing, W., Yitong, J., Willems, L., Hongfei, Z., Ting, X., & Shaohua, H. (December 2018). Genomic sequence and virulence of a novel NADC30-like porcine reproductive and respiratory syndrome virus isolate from the Hebei province of China. Microbial Pathogenesis, 125, 349-360. doi:10.1016/j.micpath.2018.08.048

Jaworski, J. P., Pluta, A., Rola-Łuszczak, M., McGowan, S. L., Finnegan, C., Heenemann, K., Carignano, H. A., Alvarez, I., Murakami, K., Willems, L., Vahlenkamp, T. W., Trono, K. G., Choudhury, B., & Kuzmak, J. (July 2018). Interlaboratory Comparison of Six Real-Time PCR Assays for Detection of Bovine Leukemia Virus Proviral DNA. Journal of Clinical Microbiology, 56 (7). doi:10.1128/JCM.00304-18

Hoyos, C., Hamaïdia, M., Black, I., DUYSINX, B., LOUIS, R., & Willems, L. (28 May 2018). Immunoediting activity of macrophages against mesothelioma cells. Poster session presented at Séminaire de l'EDT-Immunologie, Liège, Belgium.

Gazon, H., Chauhan, P. S., Hamaïdia, M., Hoyos, C., Li, L., Safari, R., & Willems, L. (15 January 2018). How Does HTLV-1 Undergo Oncogene-Dependent Replication Despite a Strong Immune Response? Frontiers in Microbiology, 8, 2684. doi:10.3389/fmicb.2017.02684

Jantsch, M. F., Quattrone, A., O'Connell, M., Willems, L., Ule, J., & Fray, R. (2018). Positioning Europe for the EPITRANSCRIPTOMICS challenge. RNA Biology, 15. doi:10.1080/15476286.2018.1460996

Sriramareddy, S., HAMOIR, E., CHAVEZ, V., LOUIS, R., Beckers, A., & Willems, L. (2018). Tumor cells may circulate in medullary thyroid cancer patients independently of serum calcitonin. Endocrine-Related Cancer, 25 (12). doi:10.1530/ERC-18-0180

Xiukun, S., Ting, X., Xiaoyu, G., Hong, J., Ming, L., Xintao, G., Jing, W., Yitong, J., Willems, L., Hongfei, Z., & Shaohua, H. (2018). Genomic characterization and pathogenic study of two porcine reproductive and respiratory syndrome viruses with different virulence in Fujian, China. Journal of Veterinary Science, 19 (3), 339-349. doi:10.4142/jvs.2018.19.3.339

Gallo, R., Willems, L., & Tagaya, Y. (22 September 2017). Time to Go Back to the Original Name. Frontiers in Microbiology, 8, 1800. doi:10.3389/fmicb.2017.01800

Rondelet, G., Fleury, L., Faux, C., Masson, V., Dubois, J., Arimondo, P., Willems, L., & Wouters, J. (10 August 2017). Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors. Future Medicinal Chemistry, 9 (13). doi:10.4155/fmc-2017-0074

Li, B., Leblois, J., Taminiau, B., Willems, L., Beckers, Y., Bindelle, J., & Everaert, N. (08 May 2017). The effect of inulin and/or wheat bran in the diet during early life on intestinal health of broiler chicks. Paper presented at 21st European Symposium on Poultry Nutrition (ESPN 2017).

Staumont, B., Costa, C., Vandermeers, F., Neelature Sriramareddy, S., Mascaux, C., Scherpereel, A., DUYSINX, B., LOUIS, R., DELVENNE, P., Hubert, P., & Willems, L. (01 February 2017). EGFR tyrosine kinase inhibitors overcome resistance to chemotherapy in malignant pleural mesothelioma. Poster session presented at GIGA conference day: New insights into the hallmarks of cancer.

De Brogniez, A., Barez, P.-Y., CARPENTIER, A., Gutierrez, G., Reichert, M., Trono, K., & Willems, L. (2017). Quantification of Cell Turnover in the Bovine Leukemia Virus Model. Methods in Molecular Biology, 1582. doi:10.1007/978-1-4939-6872-5_13

Safari, R., Hamaïdia, M., De Brogniez, A., Gillet, N., & Willems, L. (2017). Cis-drivers and trans-drivers of bovine leukemia virus oncogenesis. Current Opinion in Virology, 26, 15-19. doi:10.1016/j.coviro.2017.06.012

Gallo, R., Willems, L., Hasegawa, H., & the Global Virus Network’s Task Force on HTLV-1. (29 December 2016). Screening transplant donors for HTLV-1 and -2. Blood, 128 (26). doi:10.1182/blood-2016-09-739433

Willems, L., Hasegawa, H., Accolla, R., Bangham, C., Bazarbachi, A., Bertazzoni, U., Barbara de Freitas Carneiro-Proietti, A., Cheng, H., Chieco-Bianchi, L., Ciminale, V., Coelho-dos-Reis, J., Esparza, J., Gallo, R. C., Gessain, A., Gotuzzo, E., Hall, W., Harford, J., Hermine, O., Jacobson, S., ... Yamano, Y. (11 November 2016). Reducing the global burden of HTLV-1 infection: An agenda for research and action. Antiviral Research, 137 (2017), 41-48. doi:10.1016/j.antiviral.2016.10.015

Merlini, R., Gutiérrez, G., Alvarez, I., Jaworski, J. P., Carignano, H., Poli, M., Willems, L., & Trono, K. (30 July 2016). Bovine leukemia virus becomes established in dairy herds before the first lactation. Archives of Virology, 161, 3215–3217. doi:10.1007/s00705-016-2973-x

Gillet, N., Hamaïdia, M., De Brogniez, A., Gutierrez, G., Renotte, N., Reichert, M., Trono, K., & Willems, L. (28 April 2016). Bovine Leukemia Virus Small Noncoding RNAs Are Functional Elements That Regulate Replication and Contribute to Oncogenesis In Vivo. PLoS Pathogens, 12 (4). doi:10.1371/journal.ppat.1005588

Gillet, N., Hamaïdia, M., De Brogniez, A., Gutierrez, G., Renotte, N., Reichert, M., Trono, K., & Willems, L. (18 April 2016). Bovine Leukemia Virus Small Noncoding RNAs Are Functional Elements That Regulate Replication and Contribute to Oncogenesis In Vivo. Poster session presented at AACR American Association for Cancer Research Annual meeting 2016, New Orleans, United States.

De Brogniez, A., Mast, J., & Willems, L. (24 March 2016). Determinants of the Bovine Leukemia Virus envelope glycoproteins involved in infectivity, replication and pathogenesis. Viruses, 8 (4), 88. doi:10.3390/v8040088

Rondelet, G., Dal Maso, T., Willems, L., & Wouters, J. (15 March 2016). Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B. Journal of Structural Biology, 194, 357–367. doi:10.1016/j.jsb.2016.03.013

Hamaïdia, M., Barez, P.-Y., Carpentier, A., Lebecque, S., Miazek, K., Paul, A., Neelature Sriramareddy, S., Staumont, B., Danthine, S., Deleu, M., Frederich, M., De Pauw, E., Delaplace, P., Delvigne, F., Goffin, D., Ongena, M., DUYSINX, B., LOUIS, R., cosse, J.-P., & Willems, L. (27 February 2016). From Valeriana officinalis to cancer therapy: the success of a bio-sourced compound. Biotechnologie, Agronomie, Société et Environnement, 20 (S1), 314-320.

Borchani, C., Fonteyn, F., Jamin, G., Destain, J., Willems, L., Paquot, M., Blecker, C., & Thonart, P. (2016). Structural Characterization, Technological Functionality and Physiological Aspects of Fungal β-D-Glucans : A Review. Critical Reviews in Food Science and Nutrition, 56 (10), 1746-1752. doi:10.1080/10408398.2013.854733

De Brogniez, A., & Willems, L. (2016). Viruses within animal genome. Revue Scientifique et Technique. Office International des Epizooties. doi:10.20506/rst/35.1.2423

Gillet, N., & Willems, L. (2016). Whole genome sequencing of 51 breast cancers reveals that tumors are devoid of bovine leukemia virus DNA. Retrovirology, 13:75. doi:10.1186/s12977-016-0308-3

Hamaïdia, M., Staumont, B., DUYSINX, B., LOUIS, R., & Willems, L. (2016). Improvement of malignant pleural mesothelioma immunotherapy by epigenetic modulators. Current Topics in Medicinal Chemistry, 16 (7). doi:10.2174/1568026615666150825141152

Miazek, K., Lebecque, S., Hamaïdia, M., Paul, A., Danthine, S., Willems, L., Frederich, M., De Pauw, E., Deleu, M., Richel, A., & Goffin, D. (2016). Sphingolipids: Promising lipid-class molecules with potential applications for industry. A review. Biotechnologie, Agronomie, Société et Environnement, 20 (S1), 321-336.

Paul, A., Frederich, M., Uyttenbroeck, R., Hatt, S., Malik, P., Lebecque, S., Hamaïdia, M., Miazek, K., Goffin, D., Willems, L., Deleu, M., Fauconnier, M.-L., Richel, A., De Pauw, E., Blecker, C., Monty, A., Francis, F., Haubruge, E., & Danthine, S. (2016). Grasshoppers as a food source? A review. Biotechnologie, Agronomie, Société et Environnement, 20 (AgricultureIsLife), 337-352.

Staumont, B., Costa, C., Vandermeers, F., Neelature Sriramareddy, S., Mascaux, C., Scherpereel, A., DUYSINX, B., LOUIS, R., DELVENNE, P., Hubert, P., & Willems, L. (2016). EGFR tyrosine kinase inhibitors overcome resistance to chemotherapy in malignant pleural mesothelioma. In Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016.

Gillet, N., Hamaïdia, M., De Brogniez, A., Gutierrez, G., Renotte, N., Reichert, M., Trono, K., & Willems, L. (18 December 2015). Bovine leukemia virus microRNAs regulate replication and contribute to oncogenesis in vivo. Paper presented at Third annual meeting Belgian Society for Virology.

Neelature Sriramareddy, S., Staumont, B., & Willems, L. (03 December 2015). Targeting cell cycle checkpoints and DNA damage response in Thyroid cancer. Poster session presented at 28th Televie Seminar.

Barez, P.-Y., De Brogniez, A., Carpentier, A., Gazon, H., Gillet, N., Gutiérrez, G., Hamaïdia, M., Jacques, J.-R., Perike, S., Neelature Sriramareddy, S., Renotte, N., Staumont, B., Reichert, M., Trono, K., & Willems, L. (24 November 2015). Recent advances in BLV research. Viruses, 7 (11), 6080-6088. doi:10.3390/v7112929

Berghmans, T., Lafitte, J.-J., Scherpereel, A., Ameye, L., Paesmans, M., Meert, A.-P., Colinet, B., Tulippe, C., Willems, L., Leclercq, N., & Sculier, J.-P. (19 October 2015). VAC chemotherapy with valproic acid for refractory/relapsing small cell lung cancer: a phase II study. ERJ Open Research, 1 (2). doi:10.1183/23120541.00029-2015

Hubaux, R., Vandermeers, F., Cosse, J.-P., Crisanti, C., Kapoor, V., Albelda, S. M., Mascaux, C., Delvenne, P., Hubert, P., & Willems, L. (19 October 2015). Valproic acid improves second-line regimen of small cell lung carcinoma in preclinical models. ERJ Open Research, 1 (2), 00028. doi:10.1183/23120541.00028-2015

Carpentier, A., Barez, P.-Y., Hamaïdia, M., Gazon, H., De Brogniez, A., Perike, S., Gillet, N., & Willems, L. (07 July 2015). Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence. Viruses, 7, 3603-3624. doi:10.3390/v7072793

Gillet, N., Hamaïdia, M., De Brogniez, A., Gutierrez, G., Renotte, N., Reichert, M., Trono, K., & Willems, L. (19 June 2015). The bovine leukemia virus microRNAs are dispensable for infection but contribute to viral replication in the natural host. Paper presented at 17th International Conference on Human Retrovirology: HTLV & Related Viruses, Trois ilets, Martinique, France.

Shiva Shankar, T. V., Sulka, B., Hubert, P., Hubaux, R., Delvenne, P., Pendeville-Samain, H., Boittiaux, I., Lambert, D. M., Wouters, J., Maillard, C., Blacher, S., Noël, A., Struman, I., & Willems, L. (12 June 2015). N-Hydroxy-6-(5-Nitro- Naphtalimide)-Hexanamide Inhibits Lysine Deacetylation, Mitigates Angiogenesis and Reduces Tumor Growth. Journal of Cancer Sciences, 2 (1).

Willems, L., & Gillet, N. (2015). APOBEC3 Interference during Replication of Viral Genomes. Viruses. doi:10.3390/v7062757

Barez, P.-Y., Carpentier, A., Boxus, M., & Willems, L. (13 May 2015). Interaction of HTLV-1 Tax with minichromosome maintenance proteins modulates viral transcription. Poster session presented at GIGA-Cancer Day 2015, Liège, Belgium.

Carpentier, A., Barez, P.-Y., Boxus, M., & Willems, L. (13 May 2015). Checkpoints modulation by the human T-lymphotropic virus type 1 (HTLV-1) Tax protein : towards new therapeutic approaches. Poster session presented at GIGA Cancer Day 2015, Liège, Belgium.

Neelature Sriramareddy, S., Staumont, B., & Willems, L. (13 May 2015). Targeting cell cycle checkpoints and DNA damage response in Thyroid cancer. Paper presented at GIGA Cancer Day.

Barez, P.-Y., Hamaïdia, M., & Willems, L. (24 April 2015). Highlights on CRISPR-Cas 9: from bacteria to eukaryotic cells. Paper presented at GIGA-Cancer Seminar.

Carpentier, A., Barez, P.-Y., Boxus, M., & Willems, L. (11 February 2015). Reprogramming of replication origin firing and checkpoint adaptation in adult T-cell leukemia. Paper presented at Séminaire des chercheurs Télévie 2015, Bruxelles, Belgium.

Carpentier, A., Barez, P.-Y., Boxus, M., & Willems, L. (11 February 2015). Checkpoints modulation by the human T-lymphotropic virus type 1 (HTLV-1) Tax protein : towards new therapeutic approaches. Poster session presented at Séminaire des chercheurs Télévie 2015, Bruxelles, Belgium.

De Brogniez, A., Bouzar, A.-B., Jacques, J.-R., Cosse, J.-P., Gillet, N., Callebaut, I., Reichert, M., & Willems, L. (11 February 2015). Risk of emergence of a hyperpathogenic bovine leukemia virus by mutation of a single envelope N-linked glycosylation site. Poster session presented at Cancer Resaerch and Televie: the challenge for the next 10 years, Bruxelles, Belgium.

Carpentier, A., Barez, P.-Y., Boxus, M., & Willems, L. (03 February 2015). Reprogramming of replication origin firing and checkpoint adaptation in adult T-cell leukemia. Paper presented at Présentations des travaux de doctorat organisées par le département AgroBioChem de Gembloux Agro Bio-Tech, Gembloux, Belgium.

Berghmans, T., Ameye, L., Lafitte, J.-J., Colinet, B., Cortot, A., CsToth, I., Holbrechts, S., Lecomte, J., Mascaux, C., Meert, A.-P., Paesmans, M., Richez, M., Scherpereel, A., Tulippe, C., Willems, L., Dernies, T., Leclercq, N., & Sculier, J.-P. (28 January 2015). Prospective validation obtained in a similar group of patients and with similar high throughput biological tests failed to confirm signatures for prediction of response to chemotherapy and survival in advanced NSCLC: a prospective study from the European Lung Cancer Working Party. Frontiers in Oncology, 4. doi:10.3389/fonc.2014.00386

Neelature Sriramareddy, S., Staumont, B., & Willems, L. (27 January 2015). Targeting cell cycle checkpoints and DNA damage response in Thyroid cancer. Poster session presented at GIGA Day-Current Advances in Medical Genetics and Genomics.

Staumont, B., Neelature Sriramareddy, S., & Willems, L. (27 January 2015). Targeting cell cycle checkpoints and DNA damage response in malignant pleural mesothelioma. Poster session presented at GIGA conference day: Current advances in medical genetics and genomics.

De Brogniez, A., Bouzar, A.-B., Jacques, J.-R., Cosse, J.-P., Gillet, N., Callebaut, I., Reichert, M., & Willems, L. (2015). Mutation of a Single Envelope N-linked Glycosylation Site Enhances the Pathogenicity of Bovine Leukemia Virus. Journal of Virology, 89 (17). doi:10.1128/JVI.00261-15

Debois, D., Fernandez, O., Franzil, L., Jourdan, E., De Brogniez, A., Willems, L., Clément, C., Dorey, S., De Pauw, E., & Ongena, M. (2015). Plant polysaccharides initiate underground crosstalk with bacilli by inducing synthesis of the immunogenic lipopeptide surfactin. Environmental Microbiology Reports, 7 (3), 570-582. doi:10.1111/1758-2229.12286

Gillet, N., Hamaïdia, M., De Brogniez, A., Gutierrez, G., Renotte, N., Reichert, M., Trono, K., & Willems, L. (2015). The bovine leukemia virus microRNAs permit escape from innate immune response and contribute to viral replication in the natural host. Retrovirology, 12.

De Brogniez, A., Bouzar, A.-B., Jacques, J.-R., Gillet, N., Callebaut, I., Reichert, M., & Willems, L. (08 December 2014). Risk of emergence of a hyperpathogenic bovine leukemia virus by mutation of a single envelope N-linked glycosylation site. Paper presented at Second annual meeting Belgian Society for Virology, Bruxelles, Belgium.

Hamaïdia, M., Cosse, J.-P., & Willems, L. (10 October 2014). Epigenetic regulation of macrophage polarisation. Paper presented at Meeting axis 4 Agriculture Is Life, Gembloux, Belgium.

De Brogniez, A., Bouzar, A.-B., Jacques, J.-R., Gillet, N., Reichert, M., & Willems, L. (05 June 2014). A Single Envelope N-linked Glycosylation Site Defines Hyperpathogenicity of Bovine Leukemia Virus. Paper presented at HERN in Rome a translational approach, Rome, Italy.

Hamaïdia, M., Cosse, J.-P., & Willems, L. (19 May 2014). Epigenetic regulation of macrophage polarisation. Paper presented at GIGA Cancer Day, Liege, Belgium.

Carpentier, A., Barez, P.-Y., Boxus, M., & Willems, L. (02 May 2014). Reprogramming of replication origin firing and checkpoint adaptation in adult T cell leukemia. Paper presented at GIGA Cancer Seminar, Liège, Belgium.

Hamaïdia, M., Cosse, J.-P., & Willems, L. (29 April 2014). Epigenetic regulation of macrophage polarisation. Poster session presented at Cancer vaccines and immunomodulation, Nantes, France.

Elemans, M., Florins, A., Willems, L., & Asquith, B. (03 April 2014). Rates of CTL Killing in Persistent Viral Infection In Vivo. PLoS Computational Biology, 4. doi:10.1371/journal.pcbi.1003534

Gillet, N., geronimo, G., rodriguez, S., De Brogniez, A., Renotte, N., alvarez, I., trono, K., & Willems, L. (April 2014). Massive Depletion of Bovine Leukemia Virus Proviral Clones Located in Genomic Transcriptionally Active Sites During Primary Infection. Poster session presented at American Association for Cancer Research annual meeting 2014, San Diego, United States.

Sainvitu, P., Nasir, M. N., Crowet, J.-M., Willems, L., Lins, L., & Deleu, M. (07 February 2014). Interactions between new phenolic glycolipids and model membrane. Poster session presented at 19th NATIONAL SYMPOSIUM on APPLIED BIOLOGICAL SCIENCES, Gembloux, Belgium.

Shiva Shankar, T. V., & Willems, L. (February 2014). Epigenetic modulators mitigate angiogenesis through a complex transcriptomic network. Vascular Pharmacology, 60, 57-66. doi:10.1016/j.vph.2014.01.003

Barez, P.-Y., Carpentier, A., Boxus, M., & Willems, L. (07 January 2014). The Tax protein and the minichromosome maintenance protein complex MCM2-7 affect cell replication and viral transcription. Retrovirology, 11 (S1), 96. doi:10.1186/1742-4690-11-S1-P96

Carpentier, A., Barez, P.-Y., Boxus, M., & Willems, L. (07 January 2014). Checkpoints modulation by the Human T-lymphotropic virus type 1 Tax protein. Retrovirology, 11 (S1), 90. doi:10.1186/1742-4690-11-S1-P90

De Brogniez, A., Bouzar, A.-B., Jacques, J.-R., Gillet, N., Pritsh, O., Tomé, L., Reichert, M., & Willems, L. (07 January 2014). Hyper-replicative bovine leukemia virus by mutation of an envelope N-linked glycosylation site. Retrovirology, 11 (1), 141. doi:10.1186/1742-4690-11-S1-P141

Gutierrez, G., Rodriguez, S. M., De Brogniez, A., Gillet, N., Golime, R., Burny, A., Jaworski, J.-P., Alvarez, I., Vagnoni, L., Trono, K., & Willems, L. (2014). Vaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm. Viruses, 6 (6), 2416-2427. doi:10.3390/v6062416

Neelature Sriramareddy, S., Staumont, B., & Willems, L. (2014). DNA Damage and Thyroid Cancer. GIGADay-2014.

Barez, P.-Y., Carpentier, A., Boxus, M., & Willems, L. (13 December 2013). Role of MCM proteins in HTLV-1 transcription. Paper presented at 2nd Belgian meeting on Deltaretroviruses.

Carpentier, A., Barez, P.-Y., Boxus, M., & Willems, L. (13 December 2013). Checkpoints modulation by Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax protein. Paper presented at 2nd Belgian HTLV Meeting.

Carpentier, A., Barez, P.-Y., Boxus, M., & Willems, L. (05 December 2013). Ckeckpoints modulation by Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax protein. Poster session presented at Séminaire des Chercheurs Télévie 2014, Bruxelles, Belgium.

Gillet, N., Gutiérrez, G., Rodriguez, S., De Brogniez, A., Renotte, N., Alvarez, I., Trono, K., & Willems, L. (October 2013). Massive Depletion of Bovine Leukemia Virus Proviral Clones Located in Genomic Transcriptionally Active Sites During Primary Infection. PLoS Pathogens, 9 (10). doi:10.1371/journal.ppat.1003687

Vandermeers, F., Neelature Sriramareddy, S., Chrisostome, C., Hubaux, R., Cosse, J.-P., & Willems, L. (September 2013). The role of epigenetics in malignant pleural mesothelioma. Lung Cancer, 81, 311-318. doi:10.1016/j.lungcan.2013.05.014

Lodewick, J., Sampaio, C., Boxus, M., Rinaldi, A.-S., Coulonval, K., Willems, L., Roger, P., & Bex, F. (23 July 2013). Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model. Retrovirology, 2013 (10), 75. doi:10.1186/1742-4690-10-75

Hamaïdia, M., Cosse, J.-P., & Willems, L. (July 2013). Effect of bio-sourced compounds on activation of immune cells in the view of to improve immunotherapy of malignant pleural mesothelioma. Poster session presented at SFR Journée Codorcet, Beauvais, France.

Gillet, N., Gutiérrez, G., Rodriguez, S., De Brogniez, A., Renotte, N., Alvarez, I., Trono, K., & Willems, L. (29 June 2013). Massive Depletion of Bovine Leukemia Virus Proviral Clones Located in Genomic Transcriptionally Active Sites During Primary Infection. Paper presented at 16th International Conference on Human Retrovirology HTLV and Related Viruses, Montreal, Canada.

Sainvitu, P., Nasir, M. N., Draguet, F., Nott, K., Lins, L., Crowet, J.-M., Willems, L., Cosse, J.-P., Jérôme, C., & Deleu, M. (30 May 2013). Novel phenolic glycolipids: antioxidant activity and effect on membrane models. Poster session presented at Knowledge for Growth, Ghent, Belgium.

Sainvitu, P., Nasir, M. N., Draguet, F., Nott, K., Lins, L., Crowet, J.-M., Willems, L., Cosse, J.-P., Jérôme, C., & Deleu, M. (15 May 2013). Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models. Poster session presented at ICBCBBE 2013 : International Conference on Bioinformatics, Computational Biology and Biomedical Engineering, Amsterdam, Netherlands.

Sainvitu, P., Nasir, M. N., Nott, K., Lins, L., Crowet, J.-M., Nicks, F., Laurent, P., Willems, L., Cosse, J.-P., Jérôme, C., & Deleu, M. (May 2013). Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models. World Academy of Science, Engineering and Technology, 77, 840.

Sainvitu, P., Nasir, M. N., Nott, K., Lins, L., Crowet, J.-M., Willems, L., Cosse, J.-P., Jérôme, C., & Deleu, M. (May 2013). Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models. World Academy of Science, Engineering and Technology, 77, 840.

Barez, P.-Y., Carpentier, A., & Willems, L. (08 February 2013). Viruses and Cancer. Paper presented at GIGA-Cancer Seminar 2013 - Journal club, Liège, Belgium.

Carpentier, A., Barez, P.-Y., & Willems, L. (28 January 2013). Interaction of HTLV-­1 Tax with minichromosome maintenance proteins accelerates the replication timing program. Paper presented at GIGA Day 2013, Liège, Belgium.

Neelature Sriramareddy, S.* , Vandermeer, F.* , costa, C.* , & Willems, L.*. (2013). The role of TGF­alpha in the resistance to mesothelioma chemotherapy. GIGA-Day 2013.
* These authors have contributed equally to this work.

Berghmans, T., Ameye, L., Willems, L., Paesmans, M., Mascaux, C., Lafitte, J. J., Meert, A. P., Scherpereel, A., Cortot, A. B., CsToth, I., Dernies, T., Toussaint, L., Leclercq, N., & Sculier, J. P. (2013). Identification of microRNA-based signatures for response and survival for non-small cell lung cancer treated with cisplatin-vinorelbine A ELCWP prospective study. Lung Cancer, 82, 340-345. doi:10.1016/j.lungcan.2013.07.020

Gillet, N., Carpentier, A., Barez, P.-Y., & Willems, L. (21 December 2012). WIP1 deficiency inhibits HTLV-1 Tax oncogenesis: novel therapeutic prospects for treatment of ATL? Retrovirology, 9 (1), 115. doi:10.1186/1742-4690-9-115

Barez, P.-Y., Carpentier, A., & Willems, L. (14 December 2012). Reprogramming of replication origin firing and checkpoint adaptation in adult T cell leukemia. Paper presented at GIGA-Cancer Seminar, Liège, Belgium.

Willems, L. (12 December 2012). Transformation by deltaretroviruses: mechanisms and therapies. Proceedings of the Belgian Royal Academies of Medicine, 1, 157-165.

Willems, L. (12 December 2012). Transformation by deltaretroviruses: mechanisms and therapies. Proceedings of the Belgian Royal Academies of Medicine, 1, 157-165.

Willems, L. (12 December 2012). Transformation by deltaretroviruses: mechanisms and therapies. Proceedings of the Belgian Royal Academies of Medicine, 1, 157-165.

Sainvitu, P., Nott, K., Nicks, F., Laurent, P., Willems, L., Cosse, J.-P., Crowet, J.-M., Lins, L., Jérôme, C., & Deleu, M. (16 November 2012). Synthesis and physico-chemical characterization of fatty esters. Poster session presented at Journée scientifique SFM-BBM, Louvain-la-neuve, Belgium.

Gillet, N., Vandermeers, F., De Brogniez, A., Florins, A., Nigro, A., François, C., Bouzar, A.-B., Verlaeten, O., Stern, E., Lambert, D., Wouters, J., & Willems, L. (2012). Chemoresistance to Valproate Treatment of Bovine Leukemia Virus-Infected Sheep; Identification of Improved HDAC Inhibitors. Pathogens, (2012-1), 65-82. doi:10.3390/pathogens1020065

Costa, C., Vandermeers, F., Reddy, N. S., Mascaux, C., Scherpereel, A., Delvenne, P., Hubert, P., & Willems, L. (13 September 2012). The role of TGF-alpha in the resistance to mesothelioma chemotherapy. Poster session presented at 11th International Conference of the International Mesothelioma Interest Group (iMig 2012), Boston, United States - Massachusetts.

Barez, P.-Y., & Willems, L. (22 June 2012). Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program. Poster session presented at GIGA-Cancer Day 2012, Liège, Belgium.

Shiva Shankar, T. V., Sulka, B., Blacher, S., Maillard, C., Noël, A., Pendeville-Samain, H., Lambert, D., Wouters, J., & Willems, L. (22 June 2012). Understanding angiogenesis through novel epigenetic modulators. Paper presented at GIGA Cancer Day, Liege, Belgium.

Costa, C., Vandermeers, F., Reddy, N. S., Hubert, P., & Willems, L. (2012). The role of TGF-alpha in resistance to mesothelioma chemotherapy.

Boxus, M., Twizere, J.-C., Legros, S., Kettmann, R., & Willems, L. (05 January 2012). Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program. Blood, 119, 151-160. doi:10.1182/blood-2011-05-356790

Boxus, M., & Willems, L. (05 January 2012). How the DNA damage response determines the fate of HTLV-1 Tax-expressing cells. Retrovirology, 9 (2). doi:10.1186/1742-4690-9-2

Florins, A.-F., De Brogniez, A., Elemans, M., Bouzar, A.-B., François, C., Reichert, M., Asquith, B., & Willems, L. (January 2012). Viral expression directs the fate of B cells in BLV-infected sheep. Journal of Virology, 86 (1), 621-624. doi:10.1128/JVI.05718-11

Olindo, S., Belrose, G., Gillet, N., Rodriguez, S., Boxus, M., Verlaeten, O., Asquith, B., Bangham, C., Signaté, A., Smadja, D., Lezin, A., Césaire, R., & Willems, L. (08 December 2011). Safety of long-term treatment of HAM/TSP patients with valproic acid. Blood, 118 (24), 6306-6309. doi:10.1182/blood-2011-04-349910

Costa, C., Vandermeers, F., Reddy, N. S., Mascaux, C., Hubert, P., Delvenne, P., & Willems, L. (2011). Thérapie du mésothéliome pleural : compréhension des mécanismes de résistance à la chimiothérapie.

Belrose, G., Gross, A., Olindo, S., Lézin, A., Dueymes, M., Komla-Soukha, I., Smadja, D., Tanaka, Y., Willems, L., Mesnard, J.-M., Peloponese, J.-M., & Césaire, R. (01 September 2011). Opposite effects of valproate on Tax and HBZ expressions in T-lymphocytes from HTLV-1 asymptomatic carriers and HAM/TSP patients. Blood, 118 (9), 2483-2491. doi:10.1182/blood-2010-11-321364

Rodriguez, S., Florins, A.-F., Gillet, N., De Brogniez, A., Sanchez-Alcaraz, M.-T., Boxus, M., Boulanger, F., Gutiérrez, G., Trono, K., Alvarez, I., Vagnoni, L., & Willems, L. (19 July 2011). Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV. Viruses, 3 (7), 1210-1248. doi:10.3390/v3071210

Shiva Shankar, T. V., Sulka, B., & Willems, L. (2011). Epigenetic regulation of angiogenesis.

Shiva Shankar, T. V., Sulka, B., Blacher, S., Maillard, C., Noël, A., Pendeville-Samain, H., Lambert, D., Wouters, J., & Willems, L. (31 January 2011). Novel HDAC/DNMT Twin inhibitors interfere with angiogenesis. Poster session presented at GIGA day.

Scherpereel, A., Berghmans, T., Lafitte, J. J., Colinet, B., Richez, M., Bonduelle, Y., Meert, A. P., Dhalluin, X., Leclercq, N., Paesmans, M., Willems, L., & Sculier, J. P. (January 2011). Valproate–doxorubicin: promising therapy for progressing mesothelioma. A phase II study. European Respiratory Journal, 37, 129-135. doi:10.1183/09031936.00037310

Shiva Shankar, T. V., Sulka, B., Blacher, S., Maillard, C., Noël, A., Pendeville, H., Lambert, D., Wouters, J., & Willems, L. (2011). Novel HDAC/DNMT Twin Inhibitors Interfere with Angiogenesis. Poster session presented at ICC on Metastasis and Angiogenesis.

Defoiche, J., Zhang, Y., Lagneaux, L., Willems, L., & Macallan, D. C. (05 August 2010). In vivo ribosomal RNA turnover is down-regulated in leukaemic cells in chronic lymphocytic leukaemia. British Journal of Haematology, 151. doi:10.1111/j.1365-2141.2010.08334.x

Hubaux, R., Vandermeers, F., Crisanti, C., Kapoor, V., Burny, A., Mascaux, C., Albelda, S. M., & Willems, L. (09 June 2010). Preclinical evidence for a beneficial impact of valproate on the response of small cell lung cancer to first-line chemotherapy. European Journal of Cancer, 46, 1724-1734. doi:10.1016/j.ejca.2010.03.021

Macallan, D. C., Defoiche, J., & Willems, L. (31 March 2010). Facilitating studies of cell proliferation in chronic lymphocytic leukemia. Leukemia Research, 34, 273-274. doi:10.1016/j.leukres.2010.04.003

Shiva Shankar, T. V., Sulka, B., Blacher, S., Maillard, C., Noël, A., Bellahcene, A., Castronovo, V., Lambert, D., Wouters, J., & Willems, L. (2010). Novel HDAC/DNMT twin inhibitors interfere with angiogenesis. Poster session presented at Keystone Symposia on Molecular and Cellular Biology.

Olindo, S., Belrose, G., Lezin, A., Gillet, N., Defoiche, J., Rodriguez, S., Signaté, A., Verlaeten, O., Smadja, D., Césaire, R., & Willems, L. (01 July 2009). Long-term treatment with valproic acid does not alleviate the condition of HAM/TSP. AIDS Research and Human Retroviruses, 25 (11), 21.

Bouzar, A., Boxus, M., Defoiche, J., Berchem, G., Macallan, D., Pettengell, R., Willis, F., Burny, A., Lagneaux, L., Bron, D., Chatelain, B., Chatelain, C., & Willems, L. (2009). Valproate synergizes with purine nucleoside analogues to induce apoptosis of B-chronic lymphocytic leukaemia cells. British Journal of Haematology, 144 (1), 41-52. doi:10.1111/j.1365-2141.2008.07426.x

Bouzar, A., Boxus, M., Florins, A.-F., Francois, C., Reichert, M., & Willems, L. (2009). Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads. Retrovirology, 6, 102. doi:10.1186/1742-4690-6-102

Boxus, M., & Willems, L. (2009). Mechanisms of HTLV-1 persistence and transformation. British Journal of Cancer, 101 (9), 1497-501. doi:10.1038/sj.bjc.6605345

Defoiche, J., Bouzar, A., Macallan, D., & Willems, L. (2009). Reduced expression of cell cycle-associated genes in B lymphocytes purified from the peripheral blood of early-stage B chronic lymphocytic leukaemia (B-CLL) patients - response to di Iasio et al. British Journal of Haematology. doi:10.1111/j.1365-2141.2009.07653.x

Defoiche, J., Zhang, Y., Lagneaux, L., Pettengell, R., Hegedus, A., Willems, L., & Macallan, D. C. (2009). Measurement of ribosomal RNA turnover in vivo by use of deuterium-labeled glucose. Clinical Chemistry, 55 (10), 1824-33. doi:10.1373/clinchem.2008.119446

Florins, A.-F., Reichert, M., Asquith, B., Bouzar, A., Jean, G., Francois, C., Jasik, A., Burny, A., Kettmann, R., & Willems, L. (2009). Earlier onset of delta-retrovirus-induced leukemia after splenectomy. PLoS ONE, 4 (9), 6943. doi:10.1371/journal.pone.0006943

Lezin, A., Olindo, S., Belrose, G., Signate, A., Cesaire, R., Smadja, D., Macallan, D., Asquith, B., Bangham, C., Bouzar, A., Gillet, N., Defoiche, J., Florins, A.-F., Verlaeten, O., Burny, A., & Willems, L. (2009). Gene activation therapy: from the BLV model to HAM/TSP patients. Frontiers in Bioscience. Scholar Edition, 1, 205-15. doi:10.2741/e20

Pomier, C., Alcaraz, M. T. S., Debacq, C. P., Lancon, A., Kerkhofs, P., Willems, L., Wattel, E., & Mortreux, F. (2009). A Dose-Effect Relationship For Deltaretrovirus-Dependent Leukemogenesis In Sheep. Retrovirology, 6. doi:10.1186/1742-4690-6-30

Vandermeers, F., Hubert, P., Delvenne, P., Mascaux, C., Grigoriu, B., Burny, A., Scherpereel, A., & Willems, L. (2009). Valproate, in combination with pemetrexed and cisplatin, provides additional efficacy to the treatment of malignant mesothelioma. Clinical Cancer Research, 15 (8), 2818-28. doi:10.1158/1078-0432.CCR-08-1579

Willems, L. (2009). The 14th International Conference on Human Retrovirology: HTLV and related retroviruses (July 1-4, 2009; Salvador, Brazil). Retrovirology, 6, 77. doi:10.1186/1742-4690-6-77

Bouzar, A., & Willems, L. (2008). How HTLV-1 may subvert miRNAs for persistence and transformation. Retrovirology, 5, 101. doi:10.1186/1742-4690-5-101

Boxus, M., Twizere, J.-C., Legros, S., Dewulf, J.-F., Kettmann, R., & Willems, L. (2008). The HTLV-1 Tax interactome. Retrovirology, 5, 76. doi:10.1186/1742-4690-5-76

Defoiche, J., Debacq, C., Asquith, B., Zhang, Y., Burny, A., Bron, D., Lagneaux, L., Macallan, D., & Willems, L. (2008). Reduction of B cell turnover in chronic lymphocytic leukaemia. British Journal of Haematology, 143 (2), 240-7. doi:10.1111/j.1365-2141.2008.07348.x

Florins, A.-F., Boxus, M., Vandermeers, F., Verlaeten, O., Bouzar, A., Defoiche, J., Hubaux, R., Burny, A., Kettmann, R., & Willems, L. (2008). Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale for host susceptibility to disease. Veterinary Immunology and Immunopathology, 125 (1-2), 1-7. doi:10.1016/j.vetimm.2008.04.007

Pomier, C., Alcaraz, M. T. S., Debacq, C., Lancon, A., Kerkhofs, P., Willems, L., Wattel, E., & Mortreux, F. (2008). Early and transient reverse transcription during primary deltaretroviral infection of sheep. Retrovirology, 5, 16. doi:10.1186/1742-4690-5-16

Vandermeers, F., Kettmann, R., & Willems, L. (2008). Implication des modifications épigénétiques dans les cancers : développement de nouvelles approches thérapeutiques. Biotechnologie, Agronomie, Société et Environnement, 12 (2).

Burteau, C., Willems, L., & Kettmann, R. (2007). Les chémokines et leurs récepteurs : rôle dans les infections virales et dans les pathologies cancéreuses. Biotechnologie, Agronomie, Société et Environnement.

Florins, A.-F., Gillet, N., Asquith, B., Boxus, M., Burteaux, C., Twizere, J.-C., Urbain, P., Vandermeers, F., Debacq, C., Sanchez-alcaraz, M. T., Schwartz-Cornil, I., Kerkhofs, P., Jean, G., Thewis, A., Hay, J., Mortreux, F., Wattel, E., Reichert, M., Burny, A., ... Willems, L. (2007). Cell dynamics and immune response to BLV infection: a unifying model. Frontiers in Bioscience: A Journal and Virtual Library, 12, 1520-1531. doi:10.2741/2165

Florins, A.-F., Gillet, N., Boxus, M., Kerkhofs, P., Kettmann, R., & Willems, L. (2007). Even attenuated bovine leukemia virus proviruses can be pathogenic in sheep. Journal of Virology, 81 (18), 10195-200. doi:10.1128/JVI.01058-07

Florins, A.-F., Gillet, N., Boxus, M., Verlaeten, O., Nigro, A., Vandermeers, F., Burteau, C., Balon, H., Bouzar, A., Defoiche, J., Burny, A., Kettmann, R., & Willems, L. (2007). Dynamique cellulaire de la pathogenèse induite par le virus de la leucémie bovine. Virologie. doi:10.1684/vir.2007.0134

Florins, A.-F., Kettmann, R., & Willems, L. (2007). Le virus de la leucemie bovine et l'homeostasie du compartiment lymphocytaire peripherique. Biotechnologie, Agronomie, Société et Environnement, 11 (1), 69-78.

Gillet, N., Florins, A.-F., Boxus, M., Burteau, C., Nigro, A., Vandermeers, F., Balon, H., Bouzar, A., Defoiche, J., Burny, A., Reichert, M., Kettmann, R., & Willems, L. (2007). Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human. Retrovirology, 4 (1), 18. doi:10.1186/1742-4690-4-18

Gillet, N., Kettmann, R., & Willems, L. (2007). Homologies entre les deux retrovirus BLV et HTLV-1 et developpement d'une nouvelle approche therapeutique basee sur la levee de la latence virale. Biotechnologie, Agronomie, Société et Environnement, 11 (2), 151-157.

Lagneaux, L., Gillet, N., Stamatopoulos, B., Delforge, A., Dejeneffe, M., Massy, M., Meuleman, N., Kentos, A., Martiat, P., Willems, L., & Bron, D. (2007). Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response. Experimental Hematology, 35 (10), 1527-37. doi:10.1016/j.exphem.2007.06.014

Lezin, A., Gillet, N., Olindo, S., Signate, A., Grandvaux, N., Verlaeten, O., Belrose, G., de Carvalho Bittencourt, M., Hiscott, J., Asquith, B., Burny, A., Smadja, D., Cesaire, R., & Willems, L. (2007). Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients. Blood, 110 (10), 3722-8. doi:10.1182/blood-2007-04-085076

Twizere, J.-C., Springael, J.-Y., Boxus, M., Burny, A., Dequiedt, F., Dewulf, J.-F., Duchateau, J., Portetelle, D., Urbain, P., Van Lint, C., Green, P. L., Mahieux, R., Parmentier, M., Willems, L., & Kettmann, R. (2007). Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling. Blood, 109 (3), 1051-60. doi:10.1182/blood-2006-06-026781

Asquith, B., Debacq, C., Florins, A.-F., Gillet, N., Sanchez-Alcaraz, T., Mosley, A., & Willems, L. (2006). Quantifying lymphocyte kinetics in vivo using carboxyfluorescein diacetate succinimidyl ester (CFSE). Proceedings of the Royal Society. Biological Sciences, 273 (1590), 1165-71. doi:10.1098/rspb.2005.3432

Debacq, C., Gillet, N., Asquith, B., Sanchez-Alcaraz, M. T., Florins, A.-F., Boxus, M., Schwartz-Cornil, I., Bonneau, M., Jean, G., Kerkhofs, P., Hay, J., Thewis, A., Kettmann, R., & Willems, L. (2006). Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep. Journal of Virology, 80 (19), 9710-9719. doi:10.1128/JVI.01022-06

Florins, A.-F., Gillet, N., Asquith, B., Debacq, C., Jean, G., Schwartz-Cornil, I., Bonneau, M., Burny, A., Reichert, M., Kettmann, R., & Willems, L. (2006). Spleen-dependent turnover of CD11b peripheral blood B lymphocytes in bovine leukemia virus-infected sheep. Journal of Virology, 80 (24), 11998-2008. doi:10.1128/JVI.01447-06

Achachi, A.* , Florins, A.-F.* , Gillet, N.* , Debacq, C., Urbain, P., Foutsop, G. M., Vandermeers, F., Jasik, A., Reichert, M., Kerkhofs, P., Lagneaux, L., Burny, A., Kettmann, R., & Willems, L. (2005). Valproate activates bovine leukemia virus gene expression, triggers apoptosis, and induces leukemia/lymphoma regression in vivo. Proceedings of the National Academy of Sciences of the United States of America, 102 (29), 10309-14. doi:10.1073/pnas.0504248102
* These authors have contributed equally to this work.

Debacq, C., Heraud, J.-M., Asquith, B., Bangham, C., Merien, F., Moules, V., Mortreux, F., Wattel, E., Burny, A., Kettmann, R., Kazanji, M., & Willems, L. (2005). Reduced cell turnover in lymphocytic monkeys infected by human T-lymphotropic virus type 1. Oncogene, 24 (51), 7514-23. doi:10.1038/sj.onc.1208896

Moules, V., Pomier, C., Sibon, D., Gabet, A.-S., Reichert, M., Kerkhofs, P., Willems, L., Mortreux, F., & Wattel, E. (2005). Fate of premalignant clones during the asymptomatic phase preceding lymphoid malignancy. Cancer Research, 65 (4), 1234-43. doi:10.1158/0008-5472.CAN-04-1834

Twizere, J.-C., Lefebvre, L., Collete, D., Debacq, C., Urbain, P., Heremans, H., Jauniaux, J.-C., Burny, A., Willems, L., & Kettmann, R. (2005). The homeobox protein MSX2 interacts with tax oncoproteins and represses their transactivation activity. Journal of Biological Chemistry, 280 (33), 29804-11. doi:10.1074/jbc.M503674200

Calomme, C., Dekoninck, A., Nizet, S., Adam, E., Nguyen, C., Van Den Broeke, A., Willems, L., Kettmann, R., Burny, A., & Van Lint, C. (2004). Overlapping Cre And E Box Motifs In The Enhancer Sequences Of The Bovine Leukemia Virus 5 ' Long Terminal Repeat Are Critical For Basal And Acetylation-Dependent Transcriptional Activity Of The Viral Promoter: Implications For Viral Latency. Journal of Virology, 78 (24), 13848-13864. doi:10.1128/JVI.78.24.13848-13864.2004

Debacq, C., Sanchez Alcaraz, M. T., Mortreux, F., Kerkhofs, P., Kettmann, R., & Willems, L. (2004). Reduced proviral loads during primo-infection of sheep by Bovine Leukemia virus attenuated mutants. Retrovirology, 1 (1), 31. doi:10.1186/1742-4690-1-31

Gillet, L., Minner, F., Detry, B., Farnir, F., Willems, L., Lambot, M., Thiry, E., Pastoret, P.-P., Schynts, F., & Vanderplasschen, A. (2004). Investigation of the susceptibility of human cell lines to bovine herpesvirus 4 infection: Demonstration that human cells can support a nonpermissive persistent infection which protects them against tumor necrosis factor alpha-induced apoptosis. Journal of Virology, 78 (5), 2336-2347. doi:10.1128/JVI.78.5.2336-2347.2004

Sanchez Alcaraz, T., Kerkhofs, P., Reichert, M., Kettmann, R., & Willems, L. (2004). Involvement of glutathione as a mechanism of indirect protection against spontaneous ex vivo apoptosis associated with bovine leukemia virus. Journal of Virology, 78 (12), 6180-9. doi:10.1128/JVI.78.12.6180-6189.2004

Silic-Benussi, M., Cavallari, L., Zorzan, T., Rossi, E., Hiraragi, H., Rosato, A., Horie, K., Saggioro, D., Lairmore, M., Willems, L., Chieco-Bianchi, L., D'Agostino, D., & Ciminale, V. (2004). Suppression Of Tumor Growth And Cell Proliferation By P13(Ii), A Mitochondrial Protein Of Human T Cell Leukemia Virus Type 1. Proceedings of the National Academy of Sciences of the United States of America, 101 (17), 6629-6634. doi:10.1073/pnas.0305502101

Willems, L. (2004). Le BLV: un modele d'etude pour les leucemies humaines. Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique, 159 (10-12), 473-8.

Debacq, C., Asquith, B., Reichert, M., Burny, A., Kettmann, R., & Willems, L. (2003). Reduced Cell Turnover In Bovine Leukemia Virus-Infected, Persistently Lymphocytotic Cattle. Journal of Virology, 77 (24), 13073-13083. doi:10.1128/JVI.77.24.13073-13083.2003

Twizere, J.-C., Kruys, V., Lefebvre, L., Vanderplasschen, A., Collete, D., Debacq, C., Lai, W. S., Jauniaux, J.-C., Bernstein, L. R., Semmes, O. J., Burny, A., Blackshear, P. J., Kettmann, R., & Willems, L. (2003). Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression. Journal of the National Cancer Institute, 95 (24), 1846-59. doi:10.1093/jnci/djg118

Debacq, C., Asquith, B., Kerkhofs, P., Portetelle, D., Kettmann, R., & Willems, L. (2002). Increased cell proliferation-but not reduced cell death-induces lymphocytosis in Bovine Leukaemia Virus-infected sheep. In Abstracts of papers presented at the 2002 meeting of retroviruses (pp. 238).

Debacq, C., Asquith, B., Kerkhofs, P., Portetelle, D., Kettmann, & Willems, L. (2002). In vivo cell turnover in BLV-infected sheep. In Société Belge de Biochimie et de Biologie moléculaire (pp. 72).

GATOT, J.-S., Callebaut, I., Van Lint, C., Demonte, D., Kekhofs, P., Portetelle, D., Burny, A., Willems, L., & Kettmann, R. (2002). Interacting surface of the receptor-binding domain. In Société Belge de Biochimie et de Biologie moléculaire (pp. 74).

Asquith, B., Debacq, C., Macallan, D., Willems, L., & Bangham, C. (2002). Lymphocyte Kinetics: The Interpretation Of Labelling Data. Trends in Immunology, 23 (12), 596-601. doi:10.1016/S1471-4906(02)02337-2

Debacq, C., Asquith, B., Kerkhofs, P., Portetelle, D., Burny, A., Kettmann, R., & Willems, L. (2002). Increased Cell Proliferation, But Not Reduced Cell Death, Induces Lymphocytosis In Bovine Leukemia Virus-Infected Sheep. Proceedings of the National Academy of Sciences of the United States of America, 99 (15), 10048-10053. doi:10.1073/pnas.142100999

GATOT, J.-S., Callebaut, I., Van Lint, C., Demonte, D., Kerkhofs, P., Portetelle, D., Burny, A., Willems, L., & Kettmann, R. (2002). Bovine Leukemia Virus Su Protein Interacts With Zinc, And Mutations Within Two Interacting Regions Differentially Affect Viral Fusion And Infectivity In Vivo. Journal of Virology, 76 (16), 7956-7967. doi:10.1128/JVI.76.16.7956-7967.2002

Lefebvre, L., Ciminale, V., Vanderplasschen, A., D'Agostino, D., Burny, A., Willems, L., & Kettmann, R. (2002). Subcellular Localization Of The Bovine Leukemia Virus R3 And G4 Accessory Proteins. Journal of Virology, 76 (15), 7843-7854. doi:10.1128/JVI.76.15.7843-7854.2002

Lefebvre, L., Vanderplasschen, A., Ciminale, V., Heremans, H., Dangoisse, O., Jauniaux, J.-C., Toussaint, J.-F., Zelnik, V., Burny, A., Kettmann, R., & Willems, L. (2002). Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase. Journal of Virology, 76 (3), 1400-1414. doi:10.1128/JVI.76.3.1400-1414.2002

Merezak, C., Reichert, M., Van Lint, C., Kerkhofs, P., Portetelle, D., Willems, L., & Kettmann, R. (2002). Inhibition Of Histone Deacetylases Induces Bovine Leukemia Virus Expression In Vitro And In Vivo. Journal of Virology, 76 (10), 5034-5042. doi:10.1128/JVI.76.10.5034-5042.2002

Debacq, C., Peremans, T., Kerkhofs, P., Portetelle, D., Kettmann, R., & Willems, L. (2001). Cell turnover in BLV-infected sheep. In Aids Research and Human Retroviruses": 10th International Conference on Human Retrovirology: HTLV and Related Viruses (pp. 13).

GATOT, J.-S., Kerkhofs, P., Burny, A., Portetelle, D., Willems, L., & Kettmann, R. (2001). A critical cysteine residue of bovine leukemia virus SU protein interacts with zinc and plays a role in viral infectivity. In The 2001 meeting on Retroviruses (pp. 181).

Cantor, G., Pritchard, S., Dequiedt, F., Willems, L., Kettmann, R., & Davis, W. (2001). Cd5 Is Dissociated From The B-Cell Receptor In B Cells From Bovine Leukemia Virus-Infected, Persistently Lymphocytotic Cattle: Consequences To B-Cell Receptor-Mediated Apoptosis. Journal of Virology, 75 (4), 1689-1696. doi:10.1128/JVI.75.4.1689-1696.2001

Debacq, C., Peremans, T., Kerkhofs, P., Portetelle, D., Kettmann, R., & Willems, L. (2001). Cell turnover in BLV-infected sheep. AIDS Research and Human Retroviruses, 17 (1), 13.

Merezak, C., Pierreux, C., Adam, E., Lemaigre, F., Rousseau, G., Calomme, C., Van Lint, C., Christophe, D., Kerkhofs, P., Burny, A., Kettmann, R., & Willems, L. (2001). Suboptimal Enhancer Sequences Are Required For Efficient Bovine Leukemia Virus Propagation In Vivo: Implications For Viral Latency. Journal of Virology, 75 (15), 6977-6988. doi:10.1128/JVI.75.15.6977-6988.2001

Reichert, M., Winnicka, A., Willems, L., Kettmann, R., & Cantor, G. (2001). Role Of The Proline-Rich Motif Of Bovine Leukemia Virus Transmembrane Protein Gp30 In Viral Load And Pathogenicity In Sheep. Journal of Virology, 75 (17), 8082-8089. doi:10.1128/JVI.75.17.8082-8089.2001

Twizere, J.-C., Kerkhofs, P., Burny, A., Portetelle, D., Willems, L., & Kettmann, R. (26 May 2000). Discordance between Bovine Leukemia Virus Tax immortalization in vitro and oncogenicity in vivo: generation of a rare CD8-positive B-lymphocyte leukemia by the TAX phosphorylation mutant. Poster session presented at 175° Réunion de la Société Belge de Biochimie et de Biologie moléculaire, Leuven, Belgium.

Vanderplasschen, A., Markine-Goriaynoff, N., Lomonte, P., Suzuki, M., Hiraoka, N., Yeh, J. C., Bureau, F., Willems, L., Thiry, E., Fukuda, M., & Pastoret, P.-P. (11 May 2000). A Multipotential Beta -1,6-N-Acetylglucosaminyl-Transferase Is Encoded by Bovine Herpesvirus Type 4. Proceedings of the National Academy of Sciences of the United States of America, 97 (11), 5756-5761. doi:10.1073/pnas.100058897

Kerkhofs, P., GATOT, J.-S., Knapen, K., Mammerickx, M., Burny, A., Portetelle, D., Willems, L., & Kettmann, R. (2000). Long-Term Protection Against Bovine Leukaemia Virus Replication In Cattle And Sheep. Journal of General Virology, 81, 957-963. doi:10.1099/0022-1317-81-4-957

Reichert, M., Cantor, G., Willems, L., & Kettmann, R. (2000). Protective Effects Of A Live Attenuated Bovine Leukaemia Virus Vaccine With Deletion In The R3 And G4 Genes. Journal of General Virology, 81, 965-969. doi:10.1099/0022-1317-81-4-965

Twizere, J.-C., Kerkhofs, P., Burny, A., Portetelle, D., Kettmann, R., & Willems, L. (2000). Discordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo. Journal of Virology, 74 (21), 9895-902. doi:10.1128/JVI.74.21.9895-9902.2000

Willems, L., Burny, A., Collete, D., Dangoisse, O., Dequiedt, F., GATOT, J.-S., Kerkhofs, P., Lefebvre, L., Merezak, C., Peremans, T., Portetelle, D., Twizere, J.-C., & Kettmann, R. (2000). Genetic Determinants Of Bovine Leukemia Virus Pathogenesis. AIDS Research and Human Retroviruses, 16 (16), 1787-95. doi:10.1089/08892220050193326

GATOT, J.-S., Callebaut, I., Mornon, J.-P., Portetelle, D., Burny, A., Kerkhofs, P., Kettmann, R., & Willems, L. (1999). Implication de la protéine transmembranaire d’enveloppe du virus de la leucémie bovine dans la fusion cellulaire et l’infectivité virale. In Séminaire de la Recherche Télévie (pp. 12).

Dequiedt, F., Cantor, G., Hamilton, V., Pritchard, S., Davis, W., Kerkhofs, P., Burny, A., Kettmann, R., & Willems, L. (1999). Bovine Leukemia Virus-Induced Persistent Lymphocytosis In Cattle Does Not Correlate With Increased Ex Vivo Survival Of B Lymphocytes. Journal of Virology, 73 (2), 1127-1137. doi:10.1128/jvi.73.2.1127-1137.1999

Willems, L., Burny, A., Dangoisse, O., Collete, D., Dequiedt, F., GATOT, J.-S., Kerkhofs, P., Lefebvre, L., Merezak, C., Portetelle, D., Twizere, J.-C., & Kettmann, R. (1999). Bovine leukemia virus as a model for human T-cell leukemia virus. Current Topics in Virology.

Burny, A., Bex, F., Dequiedt, F., Adam, E., GATOT, J.-S., Kerkhofs, P., Kettmann, R., Portetelle, D., Van Den Broeke, A., & Willems, L. (1998). Leukemia Viruses. In Encyclopedia of Immunology. Elsevier.

GATOT, J.-S., Callebaut, I., Mornon, J., Portetelle, D., Burny, A., Kerkhofs, P., Kettmann, R., & Willems, L. (1998). Conservative Mutations In The Immunosuppressive Region Of The Bovine Leukemia Virus Transmembrane Protein Affect Fusion But Not Infectivity In Vivo. Journal of Biological Chemistry, 273 (21), 12870-12880. doi:10.1074/jbc.273.21.12870

Kerkhofs, P., Heremans, H., Burny, A., Kettmann, R., & Willems, L. (1998). In Vitro And In Vivo Oncogenic Potential Of Bovine Leukemia Virus G4 Protein. Journal of Virology, 72 (3), 2554-2559. doi:10.1128/jvi.72.3.2554-2559.1998

Willems, L., Grimonpont, C., Kerkhofs, P., Capiau, C., Gheysen, D., Conrath, K., Roussef, R., Mamoun, R., Portetelle, D., Burny, A., Adam, E., Lefebvre, L., Twizere, J.-C., Heremans, H., & Kettmann, R. (1998). Phosphorylation of bovine leukemia virus Tax protein is required for in vitro transformation but not for transactivation. Oncogene, 16 (17), 2165-76. doi:10.1038/sj.onc.1201765

Dequiedt, F., Hanon, E., Kerkhofs, P., Pastoret, P.-P., Portetelle, D., Burny, A., Kettmann, R., & Willems, L. (1997). Both Wild-Type And Strongly Attenuated Bovine Leukemia Viruses Protect Peripheral Blood Mononuclear Cells From Apoptosis. Journal of Virology, 71 (1), 630-639. doi:10.1128/jvi.71.1.630-639.1997

Dequiedt, F., Willems, L., Kerkhofs, P., Burny, A., & Kettmann, R. (1997). Lack Of Mutation In The Waf1/Cip1 Gene During Bovine Leukemia Virus-Induced Leukemogenesis. Veterinary Immunology and Immunopathology, 59 (3-4), 311-322. doi:10.1016/S0165-2427(97)00081-0

GATOT, J.-S., Kettmann, R., Callebaut-Mornon, I., Portetelle, D., Kerkhofs, P., Burny, A., & Willems, L. (1997). Mutations in the immunosuppressive peptide of bovine leukema virus affect fusion and infectivity in vivo. Virus Research, 47 (2-Special Issue), 103.

Hanon, E., Hoornaert, S., Dequiedt, F., Vanderplasschen, A., Lyaku, J., Willems, L., & Pastoret, P.-P. (1997). Bovine Herpesvirus 1-Induced Apoptosis Occurs At The G0/G1 Phase Of The Cell Cycle. Virology, 232 (2), 351-358. doi:10.1006/viro.1997.8562

Kettmann, R., Grimonpont, C., Kerkhofs, P., Capiau, D., Gheysen, D., Conrate, K., Roussev, R., Mamoun, R., Portetelle, D., Burny, A., Heremans, H., & Willems, L. (1997). Phosphorylation of the Bovine Leukemia Virus transactivator p34Tax is required for transformation but not for transactivation. FASEB Journal, 11 (9), 1179.

Kiermer, V., Dequiedt, F., Masengo, R., Cleuter, Y., Briclet, D., Ciesiolka, M., Vandenbroeke, A., Willems, L., Kettmann, R., Burny, A., & Droogmans, L. (1997). The Cloning And Sequencing Of An Ovine C-Myc Cdna. DNA Sequence: the Journal of DNA Sequencing and Mapping, 7 (3-4), 235-238. doi:10.3109/10425179709034042

Willems, L., Grimonpont, C., Kerkhofs, P., Capiau, C., Gheysen, D., Conrath, K., Portetelle, D., Burny, A., Heremans, H., & Kettmann, R. (1997). Oncogenic potential of Tax requires phosphorylation on serines 106 et 293. Virus Research, 47 (2 -Special Issue), 121-122.

Willems, L., Kerkhofs, P., Attenelle, L., Burny, A., Portetelle, D., & Kettmann, R. (1997). The Major Homology Region Of Bovine Leukaemia Virus P24(Gag) Is Required For Virus Infectivity In Vivo. Journal of General Virology, 78, 637-640. doi:10.1099/0022-1317-78-3-637

Adam, E., Kerkhofs, P., Mammerickx, M., Burny, A., Kettmann, R., & Willems, L. (1996). The Creb, Atf-1, And Atf-2 Transcription Factors From Bovine Leukemia Virus-Infected B Lymphocytes Activate Viral Expression. Journal of Virology, 70 (3), 1990-1999. doi:10.1128/jvi.70.3.1990-1999.1996

Kerkhofs, P., Adam, E., Droogmans, L., Portetelle, D., Mammerickx, M., Burny, A., Kettmann, R., & Willems, L. (1996). Cellular Pathways Involved In The Ex Vivo Expression Of Bovine Leukemia Virus. Journal of Virology, 70 (4), 2170-2177. doi:10.1128/jvi.70.4.2170-2177.1996

Willardgallo, K., Delmellewibaut, C., Segurazapata, I., Janssens, M., Willems, L., & Kettmann, R. (1996). Modulation Of Cd3-Gamma Gene Expression After Hiv Type 1 Infection Of The We17/10 T Cell Line Is Progressive And Occurs In Concert With Decreased Production Of Viral P24 Antigen. AIDS Research and Human Retroviruses, 12 (8), 715-725. doi:10.1089/aid.1996.12.715

Dequiedt, F., Kettmann, R., Burny, A., & Willems, L. (1995). Nucleotide sequence of the ovine P53 tumor-suppressor cDNA and its genomic organization. DNA Sequence: the Journal of DNA Sequencing and Mapping, 5 (4), 255-9. doi:10.3109/10425179509030976

Dequiedt, F., Kettmann, R., Burny, A., & Willems, L. (1995). Mutations in the p53 tumor-suppressor gene are frequently associated with bovine leukemia virus-induced leukemogenesis in cattle but not in sheep. Virology, 209 (2), 676-83. doi:10.1006/viro.1995.1303

Dequiedt, F., Willems, L., Burny, A., & Kettmann, R. (1995). Nucleotide sequence of the bovine P53 tumor-suppressor cDNA. DNA Sequence: the Journal of DNA Sequencing and Mapping, 5 (4), 261-4. doi:10.3109/10425179509030977

Willems, L., GATOT, J.-S., Mammerickx, M., Portetelle, D., Burny, A., Kerkhofs, P., & Kettmann, R. (1995). The Yxxl Signaling Motifs Of The Bovine Leukemia-Virus Transmembrane Protein Are Required For In-Vivo Infection And Maintenance Of High Viral Loads. Journal of Virology, 69 (7), 4137-4141. doi:10.1128/jvi.69.7.4137-4141.1995

Willems, L., Heremans, H., Burny, A., & Kettmann, R. (1995). Rat embryo fibroblasts immortalization by bovine leukemia virus Tax protein. Methods in Cell Science. doi:10.1007/BF00986662

Willems, L., Kerkhofs, P., Burny, A., Mammerickx, M., & Kettmann, R. (1995). Lack of LTR and ENV genetic variation during bovine leukemia virus-induced leukemogenesis. Virology, 206 (1), 769-72. doi:10.1016/S0042-6822(95)80007-7

Adam, E., Kerkhofs, P., Mammerickx, M., Kettmann, R., Burny, A., Droogmans, L., & Willems, L. (1994). Involvement Of The Cyclic Amp-Responsive Element-Binding Protein In Bovine Leukemia-Virus Expression In-Vivo. Journal of Virology, 68 (9), 5845-5853. doi:10.1128/jvi.68.9.5845-5853.1994

Burny, A., Willems, L., Callebaut, I., Adam, E., Cludts, I., Dequiedt, F., Droogmans, L., Grimonpont, C., Kerkhofs, P., Mammerickx, M., Portetelle, D., Van Den Broeke, A., & Kettmann, R. (1994). Bovine Leukaemia Virus: biology and mode of transformation. Viruses and Cancer, Cambridge University Press.

Droogmans, L., Cludts, I., Cleuter, Y., Kerkhofs, P., Adam, E., Willems, L., Kettmann, R., & Burny, A. (1994). Expression Of Interleukin-6 Receptors And Interleukin-6 Messenger-Rna By Bovine Leukemia Virus-Induced Tumor-Cells. Cytokine, 6 (6), 641-646. doi:10.1016/1043-4666(94)90052-3

Kettmann, R., Burny, A., Callebaut, I., Droogmans, L., Mammerickx, M., Willems, L., & Portetelle, D. (1994). Bovine Leukemia Virus. The Retroviridae.

Willems, L., Kerkhofs, P., Dequiedt, F., Portetelle, D., Mammerickx, M., Burny, A., & Kettmann, R. (1994). Attenuation Of Bovine Leukemia-Virus By Deletion Of R3 And G4 Open Reading Frames. Proceedings of the National Academy of Sciences of the United States of America, 91 (24), 11532-11536. doi:10.1073/pnas.91.24.11532

Willems, L., Kettmann, R., Dequiedt, F., Portetelle, D., Voneche, V., Cornil, I., Kerkhofs, P., Burny, A., & Mammerickx, M. (1993). In vivo infection of sheep by bovine leukemia virus mutants. Journal of Virology, 67 (7), 4078-85. doi:10.1128/jvi.67.7.4078-4085.1993

Willems, L., Thienpont, E., Kerkhofs, P., Burny, A., Mammerickx, M., & Kettmann, R. (1993). Bovine leukemia virus, an animal model for the study of intrastrain variability. Journal of Virology, 67 (2), 1086-9. doi:10.1128/jvi.67.2.1086-1089.1993

Burny, A., Kettmann, R., Willems, L., Portetelle, D., Vonèche, V., Callebaut, I., Van Den Broeke, A., Mammerickx, M., Mornon, J.-P., & Brasseur, R. (1992). The interaction between Bovine Leukemia Virus and its target cell. AIDS Research and Human Retroviruses, 8, 898.

Voneche, V., Portetelle, D., Kettmann, R., Willems, L., Limbach, K., Paoletti, E., Ruysschaert, J., Burny, A., & Brasseur, R. (1992). Fusogenic Segments Of Bovine Leukemia-Virus And Simian Immunodeficiency Virus Are Interchangeable And Mediate Fusion By Means Of Oblique Insertion In The Lipid Bilayer Of Their Target-Cells. Proceedings of the National Academy of Sciences of the United States of America, 89 (9), 3810-3814. doi:10.1073/pnas.89.9.3810

Willems, L., Grimonpont, C., Heremans, H., Rebeyrotte, N., Chen, G., Portetelle, D., Burny, A., & Kettmann, R. (1992). Mutations In The Bovine Leukemia-Virus Tax Protein Can Abrogate The Long Terminal Repeat-Directed Transactivating Activity Without Concomitant Loss Of Transforming Potential. Proceedings of the National Academy of Sciences of the United States of America, 89 (9), 3957-3961. doi:10.1073/pnas.89.9.3957

Willems, L., Kettmann, R., Chen, G., Portetelle, D., Burny, A., & Derse, D. (1992). A Cyclic Amp-Responsive Dna-Binding Protein (Creb2) Is A Cellular Transactivator Of The Bovine Leukemia-Virus Long Terminal Repeat. Journal of Virology, 66 (2), 766-772. doi:10.1128/jvi.66.2.766-772.1992

Willems, L., Portetelle, D., Kerkhofs, P., Chen, G., Burny, A., Mammerickx, M., & Kettmann, R. (1992). In vivo transfection of bovine leukemia provirus into sheep. Virology, 189 (2), 775-7. doi:10.1016/0042-6822(92)90604-N

Burny, A., & Willems, L. (1991). Leukemia Viruses. In Encyclopedia of Immunology. Elsevier.

Willems, L., Burny, A., & Kettmann, R. (1991). Leukemie bij runderen: model voor leukemie veroorzaakt door een retrovirus. Kanker.

Willems, L., Kettmann, R., & Burny, A. (1991). The amino acid (157-197) peptide segment of bovine leukemia virus p34tax encompass a leucine-rich globally neutral activation domain. Oncogene, 6 (1), 159-63.

Willems, L., Kettmann, R., Chen, G., Portetelle, D., Burny, A., & Derse, D. (1991). Nucleotide sequence of the bovine cyclic-AMP responsive DNA binding protein (CREB2) cDNA. DNA Sequence: the Journal of DNA Sequencing and Mapping, 1 (6), 415-7. doi:10.3109/10425179109020800

Willems, L., Romond, P., Ghysdael, J., Burny, A., & Kettmann, R. (1991). The Bovine Leukemia-Virus Tax Gene Contains An Enhancer Sequence. Virology, 182 (1), 130-134. doi:10.1016/0042-6822(91)90656-V

Burny, A., Cleuter, Y., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., Van Den Broek, A., Willems, L., & Thomas, R. (1990). Bovine leukemia : facts and hypotheses derived from the study of an infectious cancer. Retroviruses biology and human disease, Dekker Press.

Willems, L., Heremans, H., Chen, G., Portetelle, D., Billiau, A., Burny, A., & Kettmann, R. (1990). Cooperation Between Bovine Leukemia-Virus Transactivator Protein And Ha-Ras Oncogene Product In Cellular-Transformation. EMBO Journal, 9 (5), 1577-1581. doi:10.1002/j.1460-2075.1990.tb08277.x

Burny, A., Chaput, M., Claes, V., Kettmann, R., Portetelle, D., Renaville, R., & Willems, L. (1989). Les techniques de clonage, le transfert de gènes et la régulation de l'expression chez les animaux domestiques. Biotechnologie en sélection animale, IRSIA.

Chen, G., Willems, L., Portetelle, D., Willard-Gallo, K. E., Burny, A., Gheysen, D., & Kettmann, R. (1989). Synthesis of functional bovine leukemia virus (BLV) p34tax protein by recombinant baculoviruses. Virology, 173 (1), 343-7. doi:10.1016/0042-6822(89)90254-7

Willems, L., Chen, G., Portetelle, D., Mamoun, R., Burny, A., & Kettmann, R. (1989). Structural and functional characterization of mutants of the bovine leukemia virus transactivator protein p34. Virology, 171 (2), 615-8. doi:10.1016/0042-6822(89)90633-8

Willems, L., Letellier, C., Gonze, M., Martin, R., Kettmann, R., Burny, A., & Meulemans, G. (1989). Expression Of The Bovine Leukemia-Virus Transactivator Protein-P34 By A Recombinant Vaccinia Virus. Veterinary Immunology and Immunopathology, 22 (3), 201-211. doi:10.1016/0165-2427(89)90007-X

Burny, A., Cleuter, Y., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., Van den Broeke, A., Willems, L., & Thomas, R. (1988). Bovine leukemia: facts and hypotheses derived from the study of an infectious cancer. Advances in Veterinary Science and Comparative Medicine, 32 (2), 149-70. doi:10.1016/B978-0-12-039232-2.50010-4

Burny, A., Cleuter, Y., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., Vandenbroeke, A., Willems, L., & Thomas, R. (1988). Bovine Leukemia - Facts And Hypotheses Derived From The Study Of An Infectious Cancer. Veterinary Microbiology, 17 (3), 197-218. doi:10.1016/0378-1135(88)90066-1

Burny, A., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., Van Den Broek, A., & Willems, L. (1988). Leukemogenesis by transactivating retroviruses: bovine leukemia virus as a model system. Springer-Verlag Press (Berlin, Heidelberg).

Willems, L., Chen, G., Burny, A., & Kettmann, R. (1988). Expression In Bacteria Of Beta-Galactosidase Fusion Proteins Carrying Antigenic Determinants Of The 2 X-Gene Products Of Bovine Leukemia-Virus. Leukemia, 2 (1), 1-5.

Burny, A., Cleuter, Y., Dandoy, C., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., Tartar, A., Van Den Broek, A., & Willems, L. (1987). Leukemogenesis by bovine leukemia virus (BLV). Viruses and human cancer, Liss Press, New York.

Burny, A., Cleuter, Y., Dandoy, C., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., van den Broecke, A., & Willems, L. (1987). Bovine leukemia : model system for leukemogenesis by a retrovirus. Vlaams Diergeneeskundig Tijdschrift, 56 (1), 20-27.

Burny, A., Cleuter, Y., Dandoy, C., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., Van Den Broek, A., & Willems, L. (1987). Leukemogenesis by transactivating retroviruses : bovine leukemia virus as a model system. Concepts and theories in carcinogenesis.

Burny, A., Cleuter, Y., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., Van den Broeke, A., Willems, L., & Thomas, R. (1987). Bovine leukaemia: facts and hypotheses derived from the study of an infectious cancer. Cancer Surveys, 6 (1), 139-59.

Burny, A., Cleuter, Y., Kettmann, R., Mammerickx, M., Van Den Broek, A., Willems, L., & Thomas, R. (1987). Transactivation : un phénomène biologique fondamental impliqué dans la carcinogenèse. Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique.

Kettmann, R., Willems, L., Bruck, C., Grégoire, D., Van Den Broek, A., & Burny, A. (1987). Use of bovine leukemia virus proviral DNA probes for the analysis of BLV-induced leukemogenesis. Raven Press, New York.

Willems, L., Bruck, C., Portetelle, D., Burny, A., & Kettmann, R. (1987). Expression of a cDNA clone corresponding to the long open reading frame (XBL-I) of the bovine leukemia virus. Virology, 160 (1), 55-9. doi:10.1016/0042-6822(87)90043-2

Willems, L., Chen, G., Kettmann, R., & Burny, A. (1987). Expression of the pX products of the bovine leukemia virus. Cancer Letters.

Willems, L., Gegonne, A., Chen, G., Burny, A., Kettmann, R., & Ghysdael, J. (1987). The Bovine Leukemia Virus-P34 Is A Transactivator Protein. EMBO Journal, 6 (11), 3385-3389. doi:10.1002/j.1460-2075.1987.tb02661.x

Willems, L., Kettmann, R., Portetelle, D., & Burny, A. (1987). Identification of the bovine leukemia virus transactivating protein (p34x). Haematology and Blood Transfusion, 31 (1), 482-7. doi:10.1007/978-3-642-72624-8_103

Burny, A., Bruck, C., Cleuter, Y., Couez, D., Grégoire, D., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., & Willems, L. (1986). Bovine leukemia virus as an inducer of bovine leukemia. Animal models of retrovirus infection and their relationship to aids.

Burny, A., Cleuter, Y., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., Van Den Broek, A., & Willems, L. (1986). Leukemogenesis by bovine leukemia virus (BLV) and human T-cell lymphotropic viruses : facts and hypotheses. Cancer letters (suppl.).

Burny, A., Kettmann, R., Mammerickx, M., Portetelle, D., Willems, L., Cleuter, Y., Dandoy, C., Marbaix, G., & van den Broeke, A. (1986). La leucemie bovine: systeme modele de leucemogenisation par un retrovirus. Annales de Médecine Vétérinaire, 130 (4), 287-294.

Rosen, C. A., Sodroski, J. G., Willems, L., Kettmann, R., Campbell, K., Zaya, R., Burny, A., & Haseltine, W. A. (1986). The 3' region of bovine leukemia virus genome encodes a trans-activator protein. EMBO Journal, 5 (10), 2585-9. doi:10.1002/j.1460-2075.1986.tb04538.x

Burny, A., Bruck, C., Cleuter, Y., Couez, D., Deschamps, J., Ghysdael, J., Grégoire, D., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., & Willems, L. (1985). Bovine leukemia virus : a versatile agent with various pathogenic effects in various animal species. Revue de l'Institut Pasteur de Lyon.

Burny, A., Bruck, C., Cleuter, Y., Couez, D., Deschamps, J., Ghysdael, J., Grégoire, D., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., & Willems, L. (1985). Bovine leukemia virus, a versatile agent with various pathogenic effects in various animal species. Cancer Research. Supplement.

Burny, A., Bruck, C., Cleuter, Y., Couez, D., Deschamps, J., Ghysdael, J., Grégoire, D., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., & Willems, L. (1985). Bovine leukemia virus, a distinguished member of the human T-Lymphotropic viruses family. Retroviruses and human pathology (Humana Press Clifton, New Jersey).

Burny, A., Bruck, C., Cleuter, Y., Couez, D., Deschamps, J., Ghysdael, J., Grégoire, D., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., & Willems, L. (1985). Bovine leukemia virus, a distinguished member of the human T-lymphotropic virus family. Japan Sci. Soc.Press (Tokyo) / VNU Science Press (Utrecht).

Burny, A., Cleuter, Y., Couez, D., Grégoire, D., Kettmann, R., Mammerickx, M., Marbaix, G., Portetelle, D., Van den Broek, A., & Willems, L. (1985). Oncogène et traitement du cancer. Revue Médicale de Bruxelles.