Publications and communications of Dominique Engel

Ringlet, S., Caldinelli Laura, Vandries, L., Seutin, V., Jehasse, K., Pollegioni Loredano, & Engel, D. (30 June 2024). Extrasynaptic NMDARs activation by co-agonist glycine controls the occurrence of bursts in nigral dopamine neurons [Poster presentation]. Fens 2024, Vienne, Austria.

Ringlet, S., Motta, Z., Vandries, L., Seutin, V., Jehasse, K., Caldinelli, L., Pollegioni, L., & Engel, D. (2024). Co-agonist glycine controls the occurrence of bursts by activating extrasynaptic NMDARs in nigral dopamine neurons. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/319818. doi:10.1101/2024.06.06.597701

Engel, D. (08 February 2024). Contribution of extrasynaptic NMDARs to bursting activity in nigral dopamine neurons [Paper presentation]. Invitation pour donner un séminaire, Frankfurt/Main, Germany.

Robaye, L., Engel, D., Liégeois, J.-F., Kerff, F., Quertemont, E., & Seutin, V. (24 November 2023). Organotypic slice cultures from the P1 mouse dorsal raphe: Methodological development and first results [Poster presentation]. National committee of physiology and pharmacology, Autumn Meeting, Brussels, Belgium.

Colinet, M., Ghanavatinejad, F., Masset, G., Cambier, A., Helgueta Romero, S., Coumans, B., Engel, D., Nguyen, L., & Espuny Camacho, I. M. (2023). Modelling Human Brain Maturation Using 3D Cortical Organoids [Poster presentation]. BeSSCR/RBSCDB, Brussels, Belgium.

Ringlet, S., & Engel, D. (25 November 2022). Identification of the endogenous co-agonist of NMDA receptor in dopamine neurons from the substantia nigra [Paper presentation]. Belgian Society of Physiology and Pharmacology, Brussels, Belgium.

Jehasse, K., Massotte, L., Hartmann, S., Vitello, R., Ringlet, S., Vitello, M., Chua, H. C., Pless, S., Engel, D., Liégeois, J.-F., Lakaye, B., Roeper, J., & Seutin, V. (01 October 2021). The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons. Neuropharmacology, 197, 1-15. doi:10.1016/j.neuropharm.2021.108722

Moubarak, E., Engel, D., Dufour, M., Tapia, M., Tell, F., & Goaillard, J.-M. (26 June 2019). Robustness to axon initial segment variation is explained by somatodendritic excitability in rat substantia nigra dopaminergic neurons. Journal of Neuroscience, 39 (26), 5044-5063. doi:10.1523/JNEUROSCI.2781-18.2019

Destreel, G., Seutin, V., & Engel, D. (10 June 2019). Subsaturation of the NMDAR glycine site allows the regulation of bursting activity in juvenile rat nigral dopamine neurons. European Journal of Neuroscience, 50 (9), 3454-3471. doi:10.1111/ejn.14491

Engel, D. (21 February 2018). Excitability and synaptic integration in dopamine neurons of the substantia nigra [Paper presentation]. Dopamine club meeting in Hasselt, Hasselt, Belgium.

Nganou, G., Gomes Da Silva, C., Gladwyn-Ng, I., Engel, D., Coumans, B., Delgado-Escueta, A. V., Tanaka, M., Nguyen, L., Grisar, T., de Nijs, L., & Lakaye, B. (2018). Importin-8 Modulates Division of Apical Progenitors, Dendritogenesis and Tangential Migration During Development of Mouse Cortex. Frontiers in Molecular Neuroscience, 11, 234. doi:10.3389/fnmol.2018.00234

Amorim, C., Andris, F., Arckens, L., Arnould, T., Aron, S., Bakker, J., Balligand, M., Balthazart, J., Baron, F., Beck, B., Beguin, Y., Behets, C., Bellefroid, E., Bertrand, L., Bettendorff, L., Bindels, L., Blankert, B., Blanpain, C., Bondue, A., ... Wittamer, V. (2017). L’expérimentation animale reste indispensable (OPINION). La Libre Belgique.

Destreel, G., Seutin, V., & Engel, D. (08 November 2017). Modulation of NMDA receptor mediated excitatory synaptic currents in dopamine neurons of the substantia nigra [Poster presentation]. IAP FP7/10, Leuven, Belgium.

Engel, D. (06 November 2017). Excitability and synaptic integration in dopamine neurons of the substantia nigra [Paper presentation]. Monday meeting, Liege, Belgium.

Engel, D. (17 October 2017). Contribution of Ca2+ and HCN channels to the functional properties of nigral dopamine neurons [Paper presentation]. Présentation orale, Marseille, France.

Destreel, G., Seutin, V., & Engel, D. (17 May 2017). Modulation of NMDA receptor mediated excitatory synaptic currents in dopamine neurons of the substantia nigra [Poster presentation]. NeuroFrance 2017, Bordeaux, France.

Moubarak, E., Engel, D., Dufour, M., Tell, F., & Goaillard, J.-M. (May 2017). Deciphering the role of dendritic sodium channels on action potential dynamics in substantia nigra dopaminergic neurons [Poster presentation]. NeuroFrance 2017, Bordeaux, France.

Destreel, G., Seutin, V., & Engel, D. (17 March 2017). Modulation of NMDA receptor mediated excitatory synaptic currents in dopamine neurons of the substantia nigra [Poster presentation]. 96th Annual Meeting of the German Physiological Society, Greifswald, Germany.

Engel, D. (02 November 2016). Subcellular Patch-clamp Recordings from the Somatodendritic Domain of Nigral Dopamine Neurons. Journal of Visualized Experiments, 117. doi:10.3791/54601

de Vrind, V., Scuvée-Moreau, J., Drion, G., Hmaied, C., Philippart, F., Engel, D., & Seutin, V. (27 June 2016). Interactions between calcium channels and SK channels in midbrain dopamine neurons and their impact on pacemaker regularity: Contrasting roles of N- and L-type channels. European Journal of Pharmacology, 788, 274-279. doi:10.1016/j.ejphar.2016.06.046

Engel, D. (26 April 2016). Subcellular patch-clamp recordings in midbrain dopaminergic neurons [Paper presentation]. Interuniversity Attraction Poles Network 7/10, Annual Meeting. April,26 2016, Bruxelles, Belgium.

Destreel, G., Seutin, V., & Engel, D. (22 April 2016). Modulation of NMDA receptor mediated excitatory synaptic currents in dopamine neurons of the substantia nigra [Poster presentation]. Spring meeting of the society, Bruxelles, Belgium.

Philippart, F., Destreel, G., Merino-Sepulveda, P., Henny, P., Engel, D.* , & Seutin, V.*. (2016). Differential somatic Ca2+ channel profile in midbrain dopaminergic neurons. Journal of Neuroscience, 36 (27), 7234-7245. doi:10.1523/JNEUROSCI.0459-16.2016
* These authors have contributed equally to this work.

Engel, D. (06 November 2015). High dendritic expression of Ih in the proximity of the axon origin controls the integrative properties of nigral dopamine neurons [Paper presentation]. Autumn Meeting of the Belgian Society of Physiology and Pharmacology, Friday November 6th 2015, Brussels, Belgium.

Engel, D. (30 October 2015). High dendritic expression of Ih in the proximity of the axon origin controls the integrative properties of nigral dopamine neurons [Paper presentation]. Pharmacology Seminar Series, UCL School of Pharmacy, London, Friday 30 th October 2015, London, United Kingdom.

Engel, D., & Seutin, V. (09 September 2015). High dendritic expression of Ih in the proximity of the axon origin controls the integrative properties of nigral dopamine neurons. Journal of Physiology, 593 (22), 4905-4922. doi:10.1113/JP271052

Engel, D. (28 April 2015). Hyperpolarization-activated cation current Ih influences synaptic integration properties in substantia nigra dopamine neurons [Poster presentation]. Meeting Belgium Society of Neurosciences, Mons, Belgium.

Engel, D., & Seutin, V. (18 March 2015). High dendritic expression of Ih in the proximity of the axon origin controls the integrative properties of nigral dopamine neurons [Poster presentation]. 11th Göttingen Meeting of the German Neuroscience Society, March 18 - 21, 2015, Göttingen, Germany.

de Vrind, V., Philippart, F., Drion, G., Scuvée-Moreau, J., Engel, D., & Seutin, V. (16 November 2014). Investigating the role of various types of Ca2+ channels on dopamine neuron firing patterns and their variability [Poster presentation]. Congrès de neuroscience américaine (SFN), Washington, United States.

Engel, D. (2014). Sodium Channels. In D. Engel (Ed.), Encyclopedia of Computational Neuroscience. Scholarpedia.

Grauert, A., Engel, D., & Ruiz, A. (01 January 2014). Endogenous zinc depresses GABAergic transmission via T-type Ca(2+) channels and broadens the time window for integration of glutamatergic inputs in dentate granule cells. Journal of Physiology, 592, 67-86. doi:10.1113/jphysiol.2013.261420

Engel, D., & Seutin, V. (19 April 2013). Hyperpolarization-activated cation channels influence synaptic integration properties in substantia nigra dopamine neurons [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie, Bruxelles, Belgium.

Engel, D. (24 January 2013). Hyperpolarization-activated cation currents Ih influence synaptic integration properties in substantia nigra dopamine neurons [Poster presentation]. GIGA Days, Liege, Belgium.

Grauert, A., Engel, D., & Ruiz, A. (2012). Mossy fiber zinc modulates di-synaptic GABAergic transmission and tunes the integration window of excitatory synaptic input [Paper presentation]. UCL Neuroscience Symposium, London, United Kingdom.

Grauert, A., Engel, D., & Ruiz, A. (2011). Endogenous zinc modulates di-synaptic GABAergic transmission in the dentate gyrus [Poster presentation]. UCL Neuroscience Symposium, London, United Kingdom.

Seutin, V., & Engel, D. (2010). Differences in Na+ Conductance Density and Na+ Channel Functional Properties Between Dopamine and GABA Neurons of the Rat Substantia Nigra. Journal of Neurophysiology, 103. doi:10.1152/jn.00513.2009

Waroux, O., Bonjean, M., Drion, G., Engel, D., Sejnowski, T., Sepulchre, R., & Seutin, V. (November 2008). Modulation of Burst Firing by KCNQ Channels in Dopaminergic Neurons: Further Mechanistic Modeling and Experimental Findings [Poster presentation]. Society for Neuroscience annual meeting 2008, Washington, DC, United States.

Engel, D. (2007). Presynaptic action potential amplification by voltage-gated Na+channels in hippocampal mossy fiber boutons. In Acta pharmaceutica.

Bischofberger, J., Engel, D., Frotscher, M., & Jonas, P. (December 2006). Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal network. Pflügers Archiv: European Journal of Physiology, 453 (3), 361-72. doi:10.1007/s00424-006-0093-2

Bischofberger, J., Engel, D., Li, L., Geiger, J., & Jonas, P. (2006). Patch-clamp recording from mossy fiber terminals in hippocampal slices. Nature Protocols, 1 (4), 2075-81. doi:10.1038/nprot.2006.312

Engel, D., & Jonas, P. (03 February 2005). Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons. Neuron, 45 (3), 405-17. doi:10.1016/j.neuron.2004.12.048

Engel, D., & Jonas, P. (23 October 2004). Presynaptic action potential amplification by voltage-gated na+channels in hippocampal mossy fiber boutons [Poster presentation]. 34th annual meeting, Society for Neurosciences, San Diego, United States.

Towers, S., Gloveli, T., Traub, R., Driver, J., Engel, D., Fradley, R., Rosahl, T., Maubach, K., Buhl, E., & Whittington, M. (15 September 2004). Alpha 5 subunit-containing GABAA receptors affect the dynamic range of mouse hippocampal kainate-induced gamma frequency oscillations in vitro. Journal of Physiology, 559 (3), 721-8. doi:10.1113/jphysiol.2004.071191

Axmacher, N., Stemmler, M., Engel, D., Draguhn, A., & Ritz, R. (January 2004). Transmitter metabolism as a mechanism of synaptic plasticity : a modeling study. Journal of Neurophysiology, 91 (1), 25-39. doi:10.1152/jn.00797.2003

Engel, D., & Jonas, P. (2004). Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons [Paper presentation]. 83th Annual congress of the "Deutsche Physiologische gesellschaft e.V, Leipzig, Germany.

Draguhn, A., Hartmann, C., Stief, F., Frahm, C., & Engel, D. (August 2003). Transmitter-Konzentration und synaptische Hemmung bei Epilepsie. Zeitschrift für Epileptologie, 16 (3), 223-228. doi:10.1007/s10309-003-0026-4

Engel, D., Pahner, I., Schulze, K., Frahm, C., Jarry, H., Ahner-Hilger, G., & Draguhn, A. (01 September 2001). Plasticity of rat central inhibitory synapses through GABA metabolism. Journal of Physiology, 535 (2), 473-82. doi:10.1111/j.1469-7793.2001.00473.x

Frahm, C., Engel, D., & Draguhn, A. (16 March 2001). Ef®cacy of background GABA uptake in rat hippocampal slices. Neuroreport, 12 (8), 1593-1596.

Stobrawa, S., Breiderhoff, T., Takamori, S., Engel, D., Schweizer, M., Zdebik, A., Bösl, M., Ruether, K., Jahn, H., & Jentsch, T. (29 January 2001). Disruption of CIC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus. Neuron, 29 (1), 185-96. doi:10.1016/S0896-6273(01)00189-1

Axmacher, N., Stemmler, M., Engel, D., Draguhn, A., & Ritz, R. (2001). Presynaptic control of efficacy of GABAergic synapses in the hippocampus. Neurocomputing, 38-40, 99-104. doi:10.1016/S0925-2312(01)00544-6

Engel, D. (2000). Modulation de la transmision GABAergique par le métabolisme du GABA et par sa recapture dans l'hippocampe de rat [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/169391

Engel, D., Endermann, U., Frahm, C., Heinemann, U., & Draguhn, A. (July 2000). Acute effects of gamma-vinyl-GABA on low-magnesium evoked epileptiform activity in vitro. Epilepsy Research, 40 (2-3), 99-107. doi:10.1016/S0920-1211(00)00112-1

Frahm, C., Engel, D., Piechotta, A., Heinemann, U., & Draguhn, A. (2000). Presence of γ-aminobutyric acid transporter mRNA in interneurons and principal cells of rat hippocampus. Neuroscience Letters, 288 (3), 175-178. doi:10.1016/S0304-3940(00)01217-9

Sabau, A., Frahm, C., Pfeiffer, M., Breustedt, J., Piechotta, A., Numberger, Engel, D., Heinemann, U., & Draguhn, A. (November 1999). Age-dependence of the anticonvulsant effects of the GABA uptake inhibitor tiagabine in vitro. European Journal of Pharmacology, 383 (3), 259-266. doi:10.1016/S0014-2999(99)00628-7

Engel, D., Schmitz, D., Gloveli, T., Frahm, C., Heinemann, U., & Draguhn, A. (November 1998). Laminar difference in GABA uptake and GAT-1 expression in rat CA1. Journal of Physiology, 512 (Pt3), 643-649. doi:10.1111/j.1469-7793.1998.643bd.x