Publications and communications of Laurence Delacroix

Pressé, M., Malgrange, B., & Delacroix, L. (07 December 2023). The Cochlear Matrisome: Importance in Hearing and Deafness. Matrix Biology: Journal of the International Society for Matrix Biology, 125, 40 - 58. doi:10.1016/j.matbio.2023.12.002

Veithen, M.* , Huyghe, A.* , Van Den Ackerveken, P., Fukada, S.-I., Kokubo, H., Breuskin, I., Nguyen, L., Delacroix, L.* , & Malgrange, B.*. (25 August 2023). Sox9 Inhibits Cochlear Hair Cell Fate by Upregulating Hey1 and HeyL Antagonists of Atoh1. Cells, 12 (17), 2148. doi:10.3390/cells12172148
* These authors have contributed equally to this work.

Pressé, M., Czajkowski, A., Delacroix, L., & Malgrange, B. (11 February 2023). Extracellular Matrix and Hearing Function: Role of Hyaluronic Acid [Paper presentation]. 2023 Midwinter meeting of the Association for Research in Otolaryngology, Orlando, United States - Florida.

Pressé, M., Czajkowski, A., Delacroix, L., & Malgrange, B. (February 2023). Extracellular Matrix and Hearing Function: Role of Hyaluronic Acid [Poster presentation]. 2023 Midwinter meeting of the Association for Research in Otolaryngology, Orlando, United States.

Pressé, M., Czajkowski, A., Delacroix, L., & Malgrange, B. (09 May 2022). Extracellular matrix and audition: unravelling the role of hyaluronic acid in hearing function [Poster presentation]. 14th Meeting of the Belgian Society for Neuroscience, Bruxelles, Belgium.

Pouyo, L. R., Chung, K., Delacroix, L., & Malgrange, B. (2021). The ubiquitin-proteasome system in normal hearing and deafness. Hearing Research, 108366. doi:10.1016/j.heares.2021.108366

Pouyo, L. R., Thelen, N., Thiry, M., Nguyen, L., Delacroix, L., & Malgrange, B. (February 2021). Roles of Nedd4-2 in the auditory portion of mouse inner ear [Poster presentation]. 44th Annual ARO MidWinter Virtual Meeting.

DELHEZ, A., LEFEBVRE, P., Pequeux, C., Malgrange, B., & Delacroix, L. (2020). Auditory function and dysfunction:estrogen makes a difference. Cellular and Molecular Life Sciences, 77, 619-635. doi:10.1007/s00018-019-03295-y

Delacroix, L. (08 September 2019). Proteostasis is essential during cochlear development for neuron survival and hair cell polarity [Paper presentation]. Inner Ear Biology Annual Meeting, Padova, Italy.

Pouyo, L. R., Thelen, N., Delacroix, L., & Malgrange, B. (September 2019). Roles of Nedd4-2 in the auditory portion of mouse inner ear [Poster presentation]. Symposium & 56th Inner Ear Biology Workshop, Padua, Italy.

Pouyo, L. R., Thelen, N., Delacroix, L., & Malgrange, B. (13 June 2019). Functions of NEDD4-2 in the auditory portion of the inner ear [Paper presentation]. BSCDB Spring meeting, June 13th, 2019, Liège, Belgium.

Czajkowski, A., Mounier, A., Delacroix, L., & Malgrange, B. (2019). Pluripotent stem cell-derived cochlear cells: a challenge in constant progress. Cellular and Molecular Life Sciences. doi:10.1007/s00018-018-2950-5

Freeman, S.* , Mateo Sánchez, S.* , Pouyo, R., Van Lerberghe, P.-B., Hanon, K., Thelen, N., Thiry, M., Morelli, G., Van Hees, L., Laguesse, S., Chariot, A., Nguyen, L., Delacroix, L.* , & Malgrange, B.*. (2019). Proteostasis is essential during cochlear development for neuron survival and hair cell polarity. EMBO Reports, 20 (9). doi:10.15252/embr.201847097
* These authors have contributed equally to this work.

Laguesse, S., Huysseune, S., Boutin, C., Tielens, S., Franco, B., Mateo Sánchez, S., Delacroix, L., Boutin, P., Malgrange, B., CHARIOT, A., Goffinet, A., Tissir, F., Creppe, C., Seuntjens, E., & Nguyen, L. (13 June 2018). Loss of Elp3 induces postnatal hydrocephalus by inducing endoplasmic reticulum stress and dysregulation of Notch signaling [Poster presentation]. BSCDB spring meeting, Liege, Belgium.

Pouyo, L. R., Freeman, S., Delacroix, L., & Malgrange, B. (24 November 2017). Roles of Nedd4.1/2 in the auditory portion of mouse inner ear [Poster presentation]. 4th Annual Meeting BeSSCR, Liège, Belgium.

Delacroix, L., Freeman, S., Mateo Sánchez, S., Pouyo, R., Czajkowski, A., Nguyen, L., & Malgrange, B. (15 November 2017). Elp3 controls early cochlear development [Paper presentation]. Annual Meeting 2017 - Society for Neuroscience, Washington DC, United States.

Pouyo, L. R., Czajkowski, A., Freeman, S., Delacroix, L., & Malgrange, B. (May 2017). Gene expression pattern of NEDD4-1/2 in the developing inner ear [Poster presentation]. 12th meeting of the Belgian Neuroscience Society, Ghent, Belgium. doi:10.3389/conf.fnins.2017.94.00092

DELHEZ, A., Manfroid, I., LEFEBVRE, P., Delacroix, L., & Malgrange, B. (2017). Potential use of estetrol in sensorineural hearing loss protection. B-ENT.

Van Den Ackerveken, P., Mounier, A., Huyghe, A., SACHELI, R., Van Lerberghe, P.-B., Volvert, M.-L., Delacroix, L., Nguyen, L., & Malgrange, B. (2017). The miR-183/ItgA3 axis is a key regulator of prosensory area during early inner ear development. Cell Death and Differentiation. doi:10.1038/cdd.2017.127

DELHEZ, A., Manfroid, I., LEFEBVRE, P., Delacroix, L., & Malgrange, B. (18 May 2016). In vivo and in vitro studies on estetrol for prevention and treatment of sensorineural hearing loss [Poster presentation]. Molecular Biology of hearing and deafness, Cambridge, United Kingdom.

Freeman, S., Mateo Sanchez, S., Delacroix, L., & Malgrange, B. (18 May 2016). Disruption of the lysine acetyltransferase Elp3 causes planar polarity defects in the mouse organ of Corti [Poster presentation]. 10th Molecular Biology of Hearing and Deafness Conference.

Czajkowski, A., Grobarczyk, B., Hanon, K., LEFEBVRE, P., Delacroix, L., & Malgrange, B. (May 2016). Derivation of cochlear cells from pathological or isogenic human iPSCs for modeling hereditary hearing loss [Poster presentation]. 10th Molecular Biology of Hearing and Deafness conference, Hinxton, United Kingdom.

Delacroix, L., Mateo Sanchez, S., Freeman, S., Nguyen, L., & Malgrange, B. (20 February 2016). Elp3 Lysine Acetyl-Transferase Controls Neuronal Survival in the Developing Inner Ear and is Crucial to Balance and Hearing [Paper presentation]. Association for Research in Otolaryngology, 39th Midwinter Meeting, San Diego, United States.

Mateo Sanchez, S., Delacroix, L., Freeman, S., Laguesse, S., Huysseune, S., Delrez, S., Chariot, A., Nguyen, L., & Malgrange, B. (25 January 2016). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. GIGA-Day.

Delacroix, L. (2016). Elp3 acetyl-transferase controls neuronal survival in the developing inner ear and is crucial to balance and hearing [Paper presentation]. 10th Molecular Biology of Hearing and Deafness Conference, Hinxton, United Kingdom.

Mateo Sanchez, S., Freeman, S., Delacroix, L., & Malgrange, B. (2016). The Role of Post-Translational Modifications in Hearing and Deafness. Cellular and Molecular Life Sciences. doi:10.1007/s00018-016-2257-3

Mateo Sanchez, S., Delacroix, L., Freeman, S., Laguesse, S., Huysseune, S., Delrez, S., Chariot, A., Nguyen, L., & Malgrange, B. (23 November 2015). UNRAVELLING THE ROLES OF LYSINE ACETYLATION BY ELP3 DURING INNER EAR DEVELOPMENT [Poster presentation]. Belgian Society for Cell and Developmental Biology (BSCDB).

Czajkowski, A., Chariot, A., Delacroix, L., & Malgrange, B. (November 2015). Unravelling Cemip expression and functions in the auditory portion of the inner ear [Poster presentation]. BSCDB - BELGIAN SOCIETY FOR CELL AND DEVELOPMENTAL BIOLOGY.

Delacroix, L. (November 2015). Sox9: a new player in hair cell differentiation [Paper presentation]. The Belgian Society for Cell and developmental Biology Autumn meeting, Leuven, Belgium.

Mateo Sanchez, S., Delacroix, L., Freeman, S., Laguesse, S., Huysseune, S., Delrez, S., Chariot, A., Nguyen, L., & Malgrange, B. (06 June 2015). UNRAVELLING THE ROLES OF LYSINE ACETYLATION BY ELP3 DURING INNER EAR DEVELOPMENT [Poster presentation]. Belgian Society for Cell and Developmental Biology (BSCDB).

Czajkowski, A., Chariot, A. (Other coll.), Delacroix, L. (Other coll.), & Malgrange, B. (Other coll.). (29 May 2015). Unravelling Cemip expression and functions in the auditory portion of the inner ear [Poster presentation]. BSCDB - BELGIAN SOCIETY FOR CELL AND DEVELOPMENTAL BIOLOGY.

Czajkowski, A., Chariot, A., Delacroix, L., & Malgrange, B. (22 May 2015). Unravelling Cemip expression and functions in the auditory portion of the inner ear [Poster presentation]. 11th meeting of the Belgian Neuroscience Society, Mons, Belgium.

Mateo Sanchez, S., Delacroix, L., Freeman, S., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (27 January 2015). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. GIGA-Day.

Delacroix, L., & Malgrange, B. (2015). Cochlear afferent innervation development. Hearing Research, 330 (PtB), 157-169. doi:10.1016/j.heares.2015.07.015

Huyghe, A.* , Van Den Ackerveken, P.* , SACHELI, R., Prevot, P.-P., Thelen, N., Renauld, J., Thiry, M., Delacroix, L., Nguyen, L., & Malgrange, B. (2015). MicroRNA-124 Regulates Cell Specification in the Cochlea through Modulation of Sfrp4/5. Cell Reports, 13, 31-42. doi:10.1016/j.celrep.2015.08.054
* These authors have contributed equally to this work.

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (27 January 2014). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Paper presentation]. GIGA-Day.

Defourny, J., Delacroix, L., & Malgrange, B. (2014). Chapter 7 – Neuronal Circuitries During Inner Ear Development. In R. Romand & I. Varela-Nieto (Eds.), Development of auditory and vestibular systems (pp. 189-212). Elsevier. doi:10.1016/B978-0-12-408088-1.00007-5

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (2014). Unravelling the roles of lysine acetyl-transferase activity of Elongator complex during inner ear development [Paper presentation]. Inner Ear Biology meeting (IEB).

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (18 October 2013). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. Belgian Society for Cell and Developmental Biology (BSCDB).

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (31 May 2013). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. BSN Congress.

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (28 January 2013). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. GIGA-DAY.

Delacroix, L. (2013). Role of SoxE genes in the development of the auditory portion of the inner ear [Paper presentation]. The Belgian Society for Neurosciences Annual Meeting, Ghent, Belgium.

Delacroix, L., Mateo Sanchez, S., Nguyen, L., Chariot, A., & Malgrange, B. (2013). Unravelling the role of lysine acetylation by Elongator complex during inner ear development [Poster presentation]. Molecular Biology of Hearing and Deafness Conference, San Francisco, United States - California.

Rahmouni, S., Delacroix, L., Liu, W., & Tautz, L. (2013). Evaluating Effects of Tyrosine Phosphatase Inhibitors on T Cell Receptor Signaling. In Phosphatase Modulators, Methods in Molecular Biology. Springer Science. doi:10.1007/978-1-62703-562-0_15

Sacheli, R., Delacroix, L., Van Den Ackerveken, P., Nguyen, L., & Malgrange, B. (2013). Gene transfer in inner ear cells: a challenging race. Gene Therapy, 20. doi:10.1038/gt.2012.51

Delacroix, L. (November 2012). Role of SoxE genes in the development of the auditory portion of the inner ear [Paper presentation]. Current trends in Biomedicine: Molecular mechanisms of inner ear development, Baeza, Spain.

Moutier, E., Ye, T., Choukrallah, M.-A., Urban, S., Osz, J., Chatagnon, A., Delacroix, L., Langer, D., Rochel, N., Moras, D., Benoit, G., & Davidson, I. (2012). Retinoic acid receptors recognise the mouse genome through binding elements with diverse spacing and topology. Journal of Biological Chemistry. doi:10.1074/jbc.M112.361790

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (04 May 2012). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. GIGA-DAY.

Tautz, L., Vang, T., Liu, W., Delacroix, L., Wu, S., Vasile, S., Dahl, R., Yang, L., MUSUMECI, L., Francis, D., Landskron, J., Tasken, K., Tremblay, M., Lie, B., Page, R., Mustelin, T., Rahmouni, S., & Rickert, R. (April 2012). Dynamic interaction between lymphoid tyrosine phosphatase and C-terminal Src kinase controls T cell activation. FASEB Journal, 26.

Delacroix, L. (2012). Role of SoxE genes in the development of the auditory portion of the inner ear [Paper presentation]. Gordon Research Conference: the auditory system, Lewiston, United States.

Delacroix, L., & Malgrange, B. (2012). Role of SoxE genes in the development of the auditory portion of the inner ear [Poster presentation]. Auditory System Gordon Research Conference, Lewiston, United States - Massachusetts.

Singh, M., Singh, P., Gaudray, G., Musumeci, L., Thielen, C., VAIRA, D., Vandergeeten, C., Delacroix, L., Van Gulck, E., Vanham, G., de Leval, L., Rahmouni, S., & MOUTSCHEN, M. (2012). An improved protocol for efficient engraftment in NOD/LTSZ-SCIDIL-2Rgammanull mice allows HIV replication and development of anti-HIV immune responses. PLoS ONE, 7 (6), 38491. doi:10.1371/journal.pone.0038491

Vang, Liu, W. H., Delacroix, L., Wu, S., Vasile, S., Dahl, R., Yang, L., Musumeci, L., Francis, D., Landskron, J., Tasken, T., Tremblay, M. L., Lie, B. A., Page, R., Mustelin, T., Rahmouni, S., Rickert, R. C., & Tautz, L. (2012). LYP inhibits T-cell activation when dissociated from CSK. Nature Chemical Biology. doi:10.1038/nchembio.916

Delacroix, L., Moutier, E., Altobelli, G., Legras, S., Poch, O., Choukrallah, M.-A., Bertin, I., Jost, B., & Davidson, I. (2010). Cell-specific interaction of retinoic acid receptors with target genes in mouse embryonic fibroblasts and embryonic stem cells. Molecular and Cellular Biology, 30 (1), 231-44. doi:10.1128/MCB.00756-09

Pignon, J.-C., Koopmansch, B., Nolens, G., Delacroix, L., Waltregny, D., & Winkler, R. (01 April 2009). Androgen receptor controls EGFR and ERBB2 gene expression at different levels in prostate cancer cell lines. Cancer Research, 69 (7), 2941-2949. doi:10.1158/0008-5472.CAN-08-3760

Allouche, A., Nolens, G., Tancredi, A., Delacroix, L., Mardaga, J., Fridman, V., Winkler, R., Boniver, J., Delvenne, P., & Begon, D. (January 2008). The combined immunodetection of AP-2alpha and YY1 transcription factors is associated with ERBB2 gene overexpression in primary breast tumors. Breast Cancer Research, 10 (1), 9. doi:10.1186/bcr1851

Delacroix, L., Moutier, E., & Davidson, I. (2008). Identification of Retinoic Acid Receptors target genes in MEFs [Poster presentation]. 8th EMBL Transcription meeting, Heidelberg, Germany.

Fadloun, A., Kobi, D., Delacroix, L., Dembele, D., Michel, I., Lardenois, A., Tisserand, J., Losson, R., Mengus, G., & Davidson, I. (2008). Retinoic acid induces TGFbeta-dependent autocrine fibroblast growth. Oncogene, 27 (4), 477-89. doi:10.1038/sj.onc.1210657

Chatel, G., Ganeff, C., Boussif, N., Delacroix, L., Briquet, A., Nolens, G., & Winkler, R. (15 December 2007). Hedgehog signaling pathway is inactive in colorectal cancer cell lines. International Journal of Cancer, 121 (12), 2622-2627. doi:10.1002/ijc.22998

Fadloun, A., Delacroix, L., & Davidson, I. (2006). Retinoic acid induces TGFbeta-dependent autocrine fibroblast growth [Poster presentation]. 7th EMBL Transcription meeting, Heidelberg, Germany.

Pignon, J.-C., Delacroix, L., Waltregny, D., & Winkler, R. (2006). Regulation by androgens of EGF receptor family members in prostate cancer cells. Proceedings of the American Association for Cancer Research.

Delacroix, L. (2005). Rôle des séquences distales du promoteur ERBB2 dans la surexpression du gène dans les cancers mammaires [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/126369

Delacroix, L., Begon, D., Chatel, G., Jackers, P., & Winkler, R. (September 2005). Distal ERBB2 promoter fragment displays specific transcriptional and nuclear binding activities in ERBB2 overexpressing breast cancer cells. DNA and Cell Biology, 24 (9), 582-594. doi:10.1089/dna.2005.24.582

Begon, D., Delacroix, L., Vernimmen, D., Jackers, P., & Winkler, R. (01 July 2005). Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells. Journal of Biological Chemistry, 280 (26), 24428-34. doi:10.1074/jbc.M503790200

Delacroix, L. (2005). Mechanisms responsible for ERBB2 gene overexpression in human breast and non-breast cancer cells. The role of AP-2 transcription factors. Cancer Therapy, 3.

Benoit, V., Chariot, A., Delacroix, L., Deregowski, V., Jacobs, N., Merville, M.-P., & Bours, V. (2004). Caspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappa B through c-FLIP-L expression. Cancer Research, 64 (8), 2684-2691. doi:10.1158/0008-5472.CAN-03-2914

Delacroix, L., & Winkler, R. (2002). Distal regulatory ERBB2 promoter regions implicated in gene overexpression in breast cancer cells [Poster presentation]. The European Association for Cancer Research Conference, Granada, Spain.

Delacroix, L., & Winkler, R. (04 May 2001). Role of a distal activating region in ERBB2 overexpression in breast cancer cells [Poster presentation]. Bioforum meeting, Liège, Belgium.

Delacroix, L., Begon, D., & Winkler, R. (01 December 2000). Role of a distal ERBB2 promoter region in the gene overexpression in breast cancer cells [Poster presentation]. Congrès annuel de la Société Belge de Biochimie, Liège, Belgium.

Delacroix, L., & Winkler, R. (October 2000). Analysis of a distal HER2 promoter activator in breast tumor cell lines [Poster presentation]. Bioforum meeting, Liège, Belgium.

Delacroix, L., Begon, D., & Winkler, R. (2000). Role of a distal ERBB2 promoter activating region in overexpression in breast cancer cells [Poster presentation]. The American Association for Cancer Research annual meeting, New Orleans, United States.

Delacroix, L., & Winkler, R. (2000). The strong transcriptional activator AP2 binds a distal HER2 enhancer in HER2 overexpressing mammary cancer cell lines [Poster presentation]. Euregional Oncology Meeting, Aachen, Germany.

Winkler, R., Delacroix, L., Bensbaho, K., Lambert, S., Collette, J., & Hodzic, D. (1999). IGF-II in primary human colorectal tumors: peptide level, activated promoters, parental imprinting and gene rearrangement. Hormone and Metabolic Research, 31 (2-3), 148-54. doi:10.1055/s-2007-978713

Hodzic, D., Delacroix, L., Willemsen, P., Bensbaho, K., Collette, J., Broux, R., Lefebvre, P., Legros, J.-J., Grooteclaes, M., & Winkler, R. (1997). Characterization of the IGF system and analysis of the possible molecular mechanisms leading to IGF-II overexpression in a mesothelioma. Hormone and Metabolic Research, 29 (11), 549-55. doi:10.1055/s-2007-979099