Publications and communications of Frédéric Kerff

Articles in scientific journals with peer reviewing

Fanara, S., Schloesser, M., Joris, M., De Franco, S., Vandevenne, M., Kerff, F., Hanikenne, M.* , & Motte, P.*. (2024). The Arabidopsis SR45 splicing factor bridges the splicing machinery and the exon-exon junction complex. Journal of Experimental Botany. doi:10.1093/jxb/erae002
* These authors have contributed equally to this work.

Kerff, F., Jourdan, S., Francis, I. M., Deflandre, B., Ribeiro Monteiro, S., Stulanovic, N., Loria, R., & Rigali, S. (2023). Common scab disease: structural basis of elicitor recognition in pathogenic Streptomyces species. Microbiology Spectrum, 0197523. doi:10.1128/spectrum.01975-23

Joiret, M., Kerff, F., Rapino, F., Close, P., & Geris, L. (July 2023). A simple geometrical model of the electrostatic environment around the catalytic center of the ribosome and its significance for the elongation cycle kinetics. Computational and Structural Biotechnology Journal, 21, 3768-3795. doi:10.1016/j.csbj.2023.07.016

Francis, I. M., Bergin, D., Deflandre, B., Gupta, S., Salazar, J. J. C., Villagrana, R., Stulanovic, N., Ribeiro Monteiro, S., Kerff, F., Loria, R., & Rigali, S. (01 February 2023). Role of Alternative Elicitor Transporters in the Onset of Plant Host Colonization by Streptomyces scabiei 87-22. Biology, 12 (2), 234. doi:10.3390/biology12020234

Robert, C., Kerff, F., Bouillenne, F., Gavage, M., Vandevenne, M., Filée, P., & Matagne, A. (2023). Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition. Journal of Biological Chemistry, 102892. doi:10.1016/j.jbc.2023.102892

Cawez, F., Mercuri, P., Morales Yánez, F. J., Maalouf, R., Vandevenne, M., Kerff, F., Guérin, V., Mainil, J., Thiry, D., Saulmont, M., Vanderplasschen, A., Lafaye, P., Aymé, G., Bogaerts, P., Dumoulin, M., & Galleni, M. (2023). Development of Nanobodies as Theranostic Agents against CMY-2-Like Class C b-Lactamases. Antimicrobial Agents and Chemotherapy. doi:10.1128/aac.01499-22

Deflandre, B., Jadot, C., Planckaert, S., Thiébaut, N., Stulanovic, N., Herman, R., Devreese, B., Kerff, F., & Rigali, S. (01 August 2022). Structure and Function of BcpE2, the Most Promiscuous GH3-Family Glucose Scavenging Beta-Glucosidase. MBio, 13 (4), 0093522. doi:10.1128/mbio.00935-22

Léonard, R., Sauvage, E., Lupo, V., Perrin, A., Sirjacobs, D., Charlier, P., Kerff, F., & Baurain, D. (18 February 2022). Was the last bacterial common ancestor a monoderm after all? Genes, 13. doi:10.3390/genes13020376

Joiret, M., Kerff, F., Rapino, F., Close, P., & Geris, L. (13 January 2022). Ribosome exit tunnel electrostatics. Physical Review. E, 105 (1), 014409-1 - 014409-43. doi:10.1103/PhysRevE.105.014409

Janssen-Weets, B., Kerff, F., Swiontek, K., Kler, S., Czolk, R., Revets, D., Kuehn, A., Bindslev-Jensen, C., Ollert, M., & Hilger, C. (2022). Mammalian derived lipocalin and secretoglobin respiratory allergens strongly bind ligands with potentially immune modulating properties. Frontiers in Allergy, 3, 958711. doi:10.3389/falgy.2022.958711

Lupo, V., Mercuri, P., Frère, J.-M., Joris, B., Galleni, M., Baurain, D.* , & Kerff, F.*. (2022). An Extended Reservoir of Class-D Beta-Lactamases in Non-Clinical Bacterial Strains. Microbiology Spectrum, 10 (2), 0031522. doi:10.1128/spectrum.00315-22
* These authors have contributed equally to this work.

Papp-Wallace, K. M., Docquier, J.-D., Kerff, F., & Power, P. (2022). Editorial: Structural and Biochemical Aspects of the Interaction of β-Lactamases With State-of-the-Art Inhibitors. Frontiers in Microbiology, 13, 849324. doi:10.3389/fmicb.2022.849324

Piccirilli, A., Mercuri, P., Segatore, B., Galleni, M., Brisdelli, F., Kerff, F., Amicosante, G., & Perilli, M. (June 2021). Laboratory Variants GESG170L, GESG170K, and GESG170H Increase Carbapenem Hydrolysis and Confer Resistance to Clavulanic Acid. Antimicrobial Agents and Chemotherapy, 65 (6), 01931-20. doi:10.1128/AAC.01931-20

Léonard, R., Leleu, M., Van Vlierberghe, M., Cornet, L., Kerff, F., & Baurain, D. (05 May 2021). ToRQuEMaDA: tool for retrieving queried Eubacteria, metadata and dereplicating assemblies. PeerJ, 9, 11348. doi:10.7717/peerj.11348

Lupo, V., Van Vlierberghe, M., Vanderschuren, H., Kerff, F., Baurain, D., & Cornet, L. (2021). Contamination in Reference Sequence Databases: Time for Divide-and-Rule Tactics. Frontiers in Microbiology, 12, 755101. doi:10.3389/fmicb.2021.755101

vettore, N., Moray, J., Brans, A., Herman, R., Charlier, P., kumita, J., Kerff, F., Dobson, C., & Dumoulin, M. (2021). Characterisation of the structural, dynamic and aggregation properties of the W64R amyloidogenic variant of human lysozyme. Biophysical Chemistry. doi:10.1016/j.bpc.2021.106563

Vitello, R., Kerff, F., & Liégeois, J.-F. (2021). Deciphering the molecular mechanism of SK2 channel activation by intracellular calcium to develop new therapeutic agents. Acta physiologica, 231, 13574. doi:10.1111/apha.13574

Boes, A., Brunel, J. M., Derouaux, A., Kerff, F., Bouhss, A., Touze, T., Breukink, E., & Terrak, M. (2020). Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b. Antibiotics. doi:10.3390/antibiotics9070373

Mercuri, P., Esposito, R., Blétard, S., Di Costanzo, S., Perilli, M., Kerff, F., & Galleni, M. (2020). Mutational Effects on Carbapenem Hydrolysis of YEM-1, a New Subclass B2 Metallo-β-Lactamase from Yersinia mollaretii. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.00105-20

Azarkan, M., Maquoi, E., Delbrassine, F., Herman, R., M'Rabet, N., Calvo-Esposito, R., Charlier, P., & Kerff, F. (2020). Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity. Scientific Reports. doi:10.1038/s41598-020-76172-5

Boes, A., Kerff, F., Herman, R., Touze, T., Breukink, E., & Terrak, M. (2020). The bacterial cell division protein fragment (E)FtsN binds to and activates the major peptidoglycan synthase PBP1b. The Journal of biological chemistry, 295 (52), 18256-18265. doi:10.1074/jbc.RA120.015951

Tian, X., Auger, R., Manat, G., Kerff, F., Mengin-Lecreulx, D., & Touzé, T. (2020). Insight into the dual function of lipid phosphate phosphatase PgpB involved in two essential cell-envelope metabolic pathways in Escherichia coli. Scientific Reports, 10 (1), 13209. doi:10.1038/s41598-020-70047-5

Azarkan, M., Feller, G., Vandenameele, J., Herman, R., El Mahyaoui, R., Sauvage, E., Vanden Broeck, A., Matagne, A., Charlier, P., & Kerff, F. (2018). Biochemical and structural characterization of a mannose binding jacalin-related lectin with two-sugar binding sites from pineapple (Ananas comosus) stem. Scientific Reports. doi:10.1038/s41598-018-29439-x

El Ghachi, M., Howe, N., Huang, C.-Y., Olieric, V., Warshamanage, R., Touze, T., Weichert, D., Stansfeld, P. J., Wang, M., Kerff, F., & Caffrey, M. (2018). Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis. Nature Communications, 9 (1), 1078. doi:10.1038/s41467-018-03477-5

Pérez-Llarena, F. J., Vázquez-Ucha, J. C., Kerff, F., Zamorano, L., Beceiro, A., Miro, E., Póvoa Cabral, M., Fleites, A., Lantero, M., Martínez-Martínez, L., Martínez-Martínez, A., Galleni, M., Navarro, F., & Bou, G. (2018). Increased antimicrobial resistance in a novel CMY-54 AmpC-type enzyme with a GluLeu217-218 insertion in the Ω-loop. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease. doi:10.1089/mdr.2017.0017

Rodríguez, M. M., Herman, R., Ghiglione, B., Kerff, F., D'Amico González, G., Bouillenne, F., Galleni, M., Handelsman, J., Charlier, P., Gutkind, G., Sauvage, E., & Power, P. (July 2017). Crystal Structure and Kinetic Analysis of the Class B3 Di-Zinc Metallo-β-Lactamase LRA-12 from an Alaskan Soil Metagenome. PLoS ONE, 12 (7), 0182043. doi:10.1371/journal.pone.0182043

El Ghachi, M., Howe, N., Auger, R., Lambion, A., Guiseppi, A., Delbrassine, F., Manat, G., Roure, S., Peslier, S., Sauvage, E., Vogeley, L., Rengifo-Gonzalez, J.-C., Charlier, P., Mengin-Lecreulx, D., Foglino, M., Touze, T., Caffrey, M., & Kerff, F. (2017). Crystal structure and biochemical characterization of the transmembrane PAP2 type phosphatidylglycerol phosphate phosphatase from Bacillus subtilis. Cellular and Molecular Life Sciences. doi:10.1007/s00018-017-2464-6

Dagnino-Leone, J., Figueroa, M., Mella, C., Vorphal, M. A., Kerff, F., Vasquez, A. J., Bunster, M., & Martinez-Oyanedel, J. (2017). Structural models of the different trimers present in the core of phycobilisomes from Gracilaria chilensis based on crystal structures and sequences. PLoS ONE, 12 (5), 0177540. doi:10.1371/journal.pone.0177540

Bottoni, C., Perilli, M., Marcoccia, F., Piccirilli, A., Pellegrini, C., Colapietro, M., Sabatini, A., Celenza, G., Kerff, F., Amicosante, G., Galleni, M., & Mercuri, P. (2016). Kinetic Studies on CphA Mutants Reveal the Role of the P158-P172 Loop in Activity versus Carbapenems. Antimicrobial Agents and Chemotherapy, 60 (5), 3123-6. doi:10.1128/AAC.01703-15

Frère, J.-M., Sauvage, E., & Kerff, F. (2016). From "an enzyme able to destroy penicillin" to Carbapenemases: 70 Years of Beta-lactamase Misbehaviour. Current Drug Targets. doi:10.2174/1389450116666151001112859

Jourdan, S.* , Francis, I.* , Kim, M., Salazar, J., Planckaert, S., Frère, J.-M., Matagne, A., Kerff, F., Devreese, B., Loria, R., & Rigali, S. (2016). The CebE/MsiK Transporter is a Doorway to the Cello-oligosaccharide-mediated Induction of Streptomyces scabies Pathogenicity. Scientific Reports. doi:10.1038/srep27144
* These authors have contributed equally to this work.

Marcoccia, F., Bottoni, C., Sabatini, A., Colapietro, M., Mercuri, P., Galleni, M., Kerff, F., Matagne, A., Celenza, G., Amicosante, G., & Perilli, M. (2016). Kinetic Study of Laboratory Mutants of NDM-1 Metallo-beta-Lactamase and the Importance of an Isoleucine at Position 35. Antimicrobial Agents and Chemotherapy, 60 (4), 2366-72. doi:10.1128/AAC.00531-15

Ghiglione, B., Rodriguez, M. M., Herman, R., Curto, L., Dropa, M., Bouillenne, F., Kerff, F., Galleni, M., Charlier, P., Gutkind, G., Sauvage, E., & Power, P. (2015). Structural and Kinetic Insights into the "Ceftazidimase" Behavior of the Extended-Spectrum beta-Lactamase CTX-M-96. Biochemistry, 54 (32), 5072-82. doi:10.1021/acs.biochem.5b00313

Manat, G., El Ghachi, M., Auger, R., Baouche, K., Olatunji, S., Kerff, F., Touze, T., Mengin-Lecreulx, D., & Bouhss, A. (2015). Membrane Topology and Biochemical Characterization of the Escherichia coli BacA Undecaprenyl-Pyrophosphate Phosphatase. PLoS ONE, 10 (11), 0142870. doi:10.1371/journal.pone.0142870

Perez, A., Perez-Llarena, F. J., Garcia, P., Kerff, F., Beceiro, A., Galleni, M., & Bou, G. (2014). New mutations in ADC-type beta-lactamases from Acinetobacter spp. affect cefoxitin and ceftazidime hydrolysis. Journal of Antimicrobial Chemotherapy. doi:10.1093/jac/dku163

Perez-Llarena, F. J., Zamorano, L., Kerff, F., Beceiro, A., Garcia, P., Miro, E., Larrosa, N., Gomez-Bertomeu, F., Mendez, J. A., Gonzalez-Lopez, J. J., Oliver, A., Galleni, M., Navarro, F., & Bou, G. (2014). Genetic and kinetic characterization of the novel AmpC beta-lactamases DHA-6 and DHA-7. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.03144-14

Ruggiero, M., Kerff, F., Herman, R., Sapunaric, F., Galleni, M., Gutkind, G., Charlier, P., Sauvage, E., & Power, P. (2014). Crystal Structure of the Extended-Spectrum β -Lactamase PER-2 and Insights into the Role of Specific Residues in the Interaction with β -Lactams and β -Lactamase Inhibitors. Antimicrobial Agents and Chemotherapy, 58 (10), 5994-6002. doi:10.1128/AAC.00089-14

Sauvage, E., Derouaux, A., Fraipont, C., Joris, M., Herman, R., Rocaboy, M., Schloesser, M., Dumas, J., Kerff, F., Nguyen-Distèche, M., & Charlier, P. (2014). Crystal structure of penicillin-binding protein 3 (PBP3) from Escherichia coli. PLoS ONE. doi:10.1371/journal.pone.0098042

Delvaux, D., Kerff, F., Murty, M. R. V. S., Lakaye, B., Czerniecki, J., Kohn, G., Wins, P., Herman, R., Gabelica, V., Heuze, F., Tordoir, X., Marée, R., Matagne, A., Charlier, P., De Pauw, E., & Bettendorff, L. (2013). Structural Determinants of Specificity and Catalytic Mechanism in mammalian 25-kDa Thiamine Triphosphatase. Biochimica et Biophysica Acta - General Subjects, 1830, 4513-4523. doi:10.1016/j.bbagen.2013.05.014

Dzhekieva, L., Adediran, S. A., Herman, R., Kerff, F., Duez, C., Charlier, P., Sauvage, E., & Pratt, R. F. (2013). Inhibition of dd-Peptidases by a Specific Trifluoroketone: Crystal Structure of a Complex with the Actinomadura R39 dd-Peptidase. Biochemistry. doi:10.1021/bi400048s

Perez-Llarena, F. J., Kerff, F., Zamorano, L., Fernandez, M. C., Nunez, M. L., Miro, E., Oliver, A., Navarro, F., & Bou, G. (2013). Characterization of the new AmpC beta-lactamase FOX-8 reveals a single mutation, Phe313Leu, located in the R2 loop that affects ceftazidime hydrolysis. Antimicrobial Agents and Chemotherapy, 57 (10), 5158-61. doi:10.1128/AAC.00818-13

Rocaboy, M., Herman, R., Sauvage, E., Remaut, H., Moonens, K., Terrak, M., Charlier, P., & Kerff, F. (2013). The crystal structure of the cell division amidase AmiC reveals the fold of the AMIN domain, a new peptidoglycan binding domain. Molecular Microbiology. doi:10.1111/mmi.12361

Pérez-Llarena, F., Fernández, A., Zamorano, L., Kerff, F., Beceiro, A., Aracil, B., Cercenado, E., Miro, E., Oliver, A., Oteo, J., Navarro, F., & Bou, G. (August 2012). Characterization of a novel IMP-28 metallo-β-lactamase from a Spanish Klebsiella oxytoca clinical isolate. Antimicrobial Agents and Chemotherapy, 56 (8), 4540-3. doi:10.1128/AAC.00776-12

Power, P., Mercuri, P., Herman, R., Kerff, F., Gutkind, G., Dive, G., Galleni, M., Charlier, P., & Sauvage, E. (2012). Novel fragments of clavulanate observed in the structure of the class A b-lactamase from Bacillus licheniformis BS3. Journal of Antimicrobial Chemotherapy, 67 (10), 2379-2387. doi:10.1093/jac/dks231

Zervosen, A., Herman, R., Kerff, F., Herman, A., Bouillez, A., Prati, F., Pratt, R. F., Frère, J.-M., Joris, B., Luxen, A., Charlier, P., & Sauvage, E. (2011). Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin binding protein. Journal of the American Chemical Society. doi:10.1021/ja200696y

Perez-Llarena, F. J., Kerff, F., Abian, O., Mallo, S., Fernandez, M. C., Galleni, M., Sancho, J., & Bou, G. (2011). Distant and new mutations in CTX-M-1 beta-lactamase affect cefotaxime hydrolysis. Antimicrobial Agents and Chemotherapy, 55 (9), 4361-8. doi:10.1128/AAC.00298-11

Vercheval, L., Di Paolo, A., Borel, F., Ferrer, J.-L., Sauvage, E., Matagne, A., Frère, J.-M., Charlier, P., Galleni, M., & Kerff, F. (25 November 2010). Three factors that modulate the activity of class D β-lactamases and interfere with the post-translational carboxylation of Lys 70. Biochemical Journal, 432 (3), 495-504. doi:10.1042/BJ20101122

Mallo, S., Pérez-Llarena, F. J., Kerff, F., Fernández-Moreira, E., Soares, N. C., Galleni, M., & Bou, G. (June 2010). A Tripeptide Deletion in the Class C beta-Lactamase FOX-4 Enzyme Impairs Cefoxitin Hydrolysis and Slightly Increases Susceptibility to beta-Lactamase Inhibitors. Journal of Antimicrobial Chemotherapy, 65 (6), 1187-94. doi:10.1093/jac/dkq115

Dzhekieva, L., Rocaboy, M., Kerff, F., Charlier, P., Sauvage, E., & Pratt, R. F. (2010). Crystal structure of a complex between the Actinomadura R39 DD-peptidase and a peptidoglycan-mimetic boronate inhibitor: interpretation of a transition state analogue in terms of catalytic mechanism. Biochemistry, 49 (30), 6411-9. doi:10.1021/bi100757c

Kerff, F., Petrella, S., Mercier, F., Sauvage, E., Herman, R., Pennartz, A., Zervosen, A., Luxen, A., Frère, J.-M., Joris, B., & Charlier, P. (2010). Specific Structural Features of the N-Acetylmuramoyl-l-Alanine Amidase AmiD from Escherichia coli and Mechanistic Implications for Enzymes of This Family. Journal of Molecular Biology, 397, 249-259. doi:10.1016/j.jmb.2009.12.038

Lamoral-Theys, D., Pottier, L., Kerff, F., Dufrasne, F., Proutiere, F., Wauthoz, N., Neven, P., Ingrassia, L., Antwerpen, P. V., Lefranc, F., Gelbcke, M., Pirotte, B., Kraus, J.-L., Neve, J., Kornienko, A., Kiss, R., & Dubois, J. (2010). Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli. Bioorganic and Medicinal Chemistry, 18 (11), 3823-33. doi:10.1016/j.bmc.2010.04.047

Merino, M., Perez-Llarena, F. J., Kerff, F., Poza, M., Mallo, S., Rumbo-Feal, S., Beceiro, A., Juan, C., Oliver, A., & Bou, G. (2010). Role of changes in the L3 loop of the active site in the evolution of enzymatic activity of VIM-type metallo-beta-lactamases. Journal of Antimicrobial Chemotherapy, 65 (9), 1950-4. doi:10.1093/jac/dkq259

Baurin, S., Vercheval, L., Bouillenne, F., Falzone, C., Brans, A., Jacquamet, L., Ferrer, J.-L., Sauvage, E., Dehareng, D., Frère, J.-M., Charlier, P., Galleni, M., & Kerff, F. (2009). Critical role of tryptophan 154 for the activity and stability of class D beta-lactamases. Biochemistry, 48 (47), 11252-63. doi:10.1021/bi901548c

Sauvage, E., Zervosen, A., Dive, G., Herman, R., Amoroso, A. M., Joris, B., Fonzé, E., Pratt, R., Luxen, A., Charlier, P., & Kerff, F. (2009). Structural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate. Journal of the American Chemical Society, 131 (42), 15262-15269. doi:10.1021/ja9051526

Sauvage, E.* , Kerff, F.* , Terrak, M., Ayala, J. A., & Charlier, P. (March 2008). The Penicillin-Binding Proteins: Structure and Role in Peptidoglycan Biosynthesis. FEMS Microbiology Reviews, 32 (2), 234-58. doi:10.1111/j.1574-6976.2008.00105.x
* These authors have contributed equally to this work.

Bebrone, C., Anne, C., Kerff, F., Garau, G., De Vriendt, K., Lantin, R., Devreese, B., Van Beeumen, J., Dideberg, O., Frère, J.-M., & Galleni, M. (2008). Mutational analysis of the zinc- and substrate-binding sites in the CphA metallo-beta-lactamase from Aeromonas hydrophila. Biochemical Journal, 414 (1), 151-9. doi:10.1042/BJ20080375

Kerff, F., Amoroso, A. M., Herman, R., Sauvage, E., Petrella, S., Filée, P., Charlier, P., Joris, B., Tabuchi, A., Nikolaidis, N., & Cosgrove, D. J. (2008). Crystal structure and activity of Bacillus subtilis YoaJ (EXLX1), a bacterial expansin that promotes root colonization. Proceedings of the National Academy of Sciences of the United States of America, 105 (44), 16876-81. doi:10.1073/pnas.0809382105

Michaux, C., Massant, J., Kerff, F., Frère, J.-M., Docquier, J.-D., Vandenberghe, I., Samyn, B., Pierrard, A., Feller, G., Charlier, P., Van Beeumen, J., & Wouters, J. (2008). Crystal structure of a cold-adapted class C beta-lactamase. FEBS Journal, 275 (8), 1687-97. doi:10.1111/j.1742-4658.2008.06324.x

Sauvage, E., Duez, C., Herman, R., Kerff, F., Petrella, S., Anderson, J. W., Adediran, S. A., Pratt, R. F., Frère, J.-M., & Charlier, P. (10 August 2007). Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide. Journal of Molecular Biology, 371 (2), 528-539. doi:10.1016/j.jmb.2007.05.071

Lee, S. H., Kerff, F., Chereau, D., Ferron, F., Klug, A., & Dominguez, R. (2007). Structural basis for the actin-binding function of missing-in-metastasis. Structure, 15 (2), 145-55. doi:10.1016/j.str.2006.12.005

Borrego-Diaz, E., Kerff, F., Lee, S. H., Ferron, F., Li, Y., & Dominguez, R. (2006). Crystal structure of the actin-binding domain of alpha-actinin 1: evaluating two competing actin-binding models. Journal of Structural Biology, 155 (2), 230-8. doi:10.1016/j.jsb.2006.01.013

Chereau, D., Kerff, F., Graceffa, P., Grabarek, Z., Langsetmo, K., & Dominguez, R. (2005). Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly. Proceedings of the National Academy of Sciences of the United States of America, 102 (46), 16644-9. doi:10.1073/pnas.0507021102

Terrak, M.* , Kerff, F.* , Langsetmo, K., Tao, T., & Dominguez, R. (2004). Structural basis of protein phosphatase 1 regulation. Nature, 429 (6993), 780-4. doi:10.1038/nature02582
* These authors have contributed equally to this work.

Kerff, F., Charlier, P., Colombo, M. L., Sauvage, E., Brans, A., Frère, J.-M., Joris, B., & Fonze, E. (11 November 2003). Crystal structure of the sensor domain of the BlaR penicillin receptor from Bacillus licheniformis. Biochemistry, 42 (44), 12835-12843. doi:10.1021/bi034976a

Sauvage, E., Kerff, F., Fonze, E., Herman, R., Schoot, B., Marquette, J. P., Taburet, Y., Prevost, D., Dumas, J., Stefanic, P., Coyette, J., Charlier, P., & Leonard, G. (2002). The 2.4-A crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin. Cellular and Molecular Life Sciences, 59 (7), 1223-32. doi:10.1007/s00018-002-8500-0

Weber, G., Delbrouck, J. M., Strivay, D., Kerff, F., & Martinot, L. (1998). Use of a variable incidence angle PIXE arrangement for studying pigment multilayers. Nuclear Instruments and Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms, 139 (1-4), 196-201. doi:10.1016/S0168-583X(97)00971-3

Scientific conferences in universities or research centers

Kerff, F. (01 February 2018). Biochemical and structural characterization of phosphatases of the PAP2 and BacA families active on membrane lipids [Paper presentation]. InBioS Day.

Kerff, F. (26 November 2013). The cell separation step of bacterial cell division [Paper presentation]. Séminaire Université de Namur, Namur, Belgium.

Kerff, F. (07 November 2011). β-lactamases de classe D : substrats, inhibiteurs, et modifications [Paper presentation]. Séminaire Université de Namur, Namur, Belgium.

Scientific congresses and symposiums

Published communications

Borrego-Diaz, E., Kerff, F., Li, Y., & Dominguez, R. (2005). Structural basis of the actin-calponin homology domain interaction. Biophysical Journal, 88 (1), 497A-497.

Chereau, D., Kerff, F., Graceffa, P., & Dominguez, R. (2005). Structural basis of the actin-WH2 domain interaction. Biophysical Journal, 88 (1), 10A-11.

Terrak, M., Kerff, F., Langsetmo, K., Gong, B. J., Tao, T., & Dominguez, R. (2004). PP1 targeting and regulation as revealed by the structure of a PP1 delta-MYPT1 complex. Biophysical Journal, 86 (1), 172A-172.

Oral communications or posters

Robaye, L., Engel, D., Liégeois, J.-F., Kerff, F., Quertemont, E., & Seutin, V. (24 November 2023). Organotypic slice cultures from the P1 mouse dorsal raphe: Methodological development and first results [Poster presentation]. National committee of physiology and pharmacology, Autumn Meeting, Brussels, Belgium.

Boes, A., Terrak, M., Kerff, F., Touzé, T., & Breukink, E. (15 November 2019). Biochemical and structural insights into the interaction of the essential domain of FtsN with PBP1b [Poster presentation]. SFMBBM.

Mercuri, P., Esposito, R., Blétard, S., Di Costanzo, S., Perilli, M., Kerff, F., & Galleni, M. (22 June 2019). Mutational Effects in Carbapenem Hydrolysis of YEM-1, a New Sub-Class B2 Metallo-beta-Lactamase from Yersinia mollaretii [Poster presentation]. asm microbe, San Francisco Ca, United States.

Kerff, F. (01 February 2019). Biochemical and structural characterization of phosphatases of the PAP2 and BacA families active on membrane lipids [Paper presentation]. Meeting of the contact group FNRS of Molecular Bacteriology.

Mercuri, P., Blétard, S., Kerff, F., & Galleni, M. (June 2017). Characterisation of the sub-class B2 metallo-β-lactamase of Yersinia mollaretii Wauters [Poster presentation]. 13th β-lactamase Meeting", Santo Stefano di Sessanio, l'Aquila, Italy.

Léonard, R., Sirjacobs, D., Sauvage, E., Kerff, F., & Baurain, D. (11 May 2017). ToRQuEMaDA: Tool for retrieving queried eubacteria, metadata and dereplicating assemblie [Poster presentation]. PhD Student Day 2017, Liège, Belgium.

Kerff, F. (21 April 2017). Bacterial phosphatases of the PAP2 family active on membrane lipids, structures and specificity [Paper presentation]. Mini-symposium « The cell envelope of Gram-negative bacteria », Bruxelles, Belgium.

Kerff, F. (29 September 2016). Structure of the classe D β-lactamase OXA-29, an original dimer [Paper presentation]. XXIII Congreso Latinoamericano de Microbiologia, Rosario, Argentina.

Vettore, N., Kumita, J., Moray, J., Brans, A., Kerff, F., Dobson, C., & Dumoulin, M. (15 September 2016). CHARACTERISATION OF THE STRUCTURAL, DYNAMIC AND AGGREGATION PROPERTIES OF THE W64R AMYLOIDOGENIC MUTANT OF LYSOZYME [Poster presentation]. CNRS - Jacques Monod Conference “Protein misfolding in disease - Toxic aggregation-prone proteins in aging and age-related diseases: from structure to pathology and spreading" - Roscoff.

Léonard, R., Baurain, D., Kerff, F., Sauvage, E., & Sirjacobs, D. (07 December 2015). On the LZ distance for dereplicating redundant prokaryotic genomes [Poster presentation]. 10th Benelux Bioinformatics Conference, Antwerp, Belgium.

Freichels, R., Delmarcelle, M., Colarusso, A., Kerff, F., Wathelet, B., & Galleni, M. (July 2015). SPECIFICITY OF CLASS I TAGATOSE 1,6-BISPHOSPHATE ALDOLASE ENHANCED TOWARD TAGATOSE 1,6-BISPHOPHATE [Poster presentation]. 12th Biotrans, Vienne, Austria.

Delbrassine, F., Auger, R., El Ghachi, M., Lambion, A., Touzé, T., Manat, G., & Kerff, F. (08 June 2015). Characterization of YbjG, a pyrophosphate phosphatase from E. coli involved in the lipid carrier undecaprenyl phosphate metabolism [Poster presentation]. The 6th Congress of European Microbiologists (FEMS 2015), Maastricht, Netherlands.

Kerff, F. (08 June 2015). Structure of the PAP2 membrane protein YodM, a typical bacterial phosphatidylglycerol-phosphate phosphatase [Paper presentation]. iPros AP meeting, Liege, Belgium.

Manat, G., Roure, S., El Ghachi, M., Auger, R., Delbrassine, F., Bouhss, A., Kerff, F., Engin-Lecreulx, D., & Touzé, T. (June 2015). Deciphering the metabolism of polyprenyl-phosphate: The universal glycan lipid carrier at the membrane frontier [Poster presentation]. The 6th Congress of European Microbiologists (FEMS 2015), Maastricht, Netherlands.

Galleni, M., Kerff, F., & Rigali, S. (05 February 2015). Résistance aux antibiotiques : le retour à l’ère prébiotique ? [Paper presentation]. Liège Creative.

Kerff, F., El Ghachi, M., Herman, R., Sauvage, E., Frère, J.-M., & Charlier, P. (06 September 2014). Structures of the Carbapenemase OXA-24 in Complex with the β-lactamase Inhibitor Avibactam [Poster presentation]. 54th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, United States - District of Columbia.

Freichels, R., Colarusso, A., Delmarcelle, M., Kerff, F., Wathelet, B., & Galleni, M. (01 June 2014). Structural studies of class I tagatose 1,6-bisphosphate aldolase : Enhanced substrate specificity toward tagatose 1,6-bisphosphate [Poster presentation]. EMBO : Enzyme mechanisms by biological systems, Manchester (UK), United Kingdom.

Kerff, F., & Caroen, J. (23 April 2014). Overview of the synthesis and structural studies of class D β-lactamases inhibitor [Paper presentation]. iPros IAP meeting, Ghent, Belgium.

Power, P., Sauvage, E., Herman, R., Gutkin, G., Galleni, M., Charlier, P., & Kerff, F. (2014). The crystal structure of the carbapenemase OXA-24 in complex with tazobactam reveals evidences about the intereaction with beta-lactamase inhibitors and lysine carboxylation [Poster presentation]. 54th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, United States - District of Columbia.

Freichels, R., Guarino, C., Delmarcelle, M., Kerff, F., Wathelet, B., & Galleni, M. (26 February 2013). Biochemical and Structural studies of the type I tagatose bisphosphate aldolases [Poster presentation]. IAP meeting "integrative protein science : from small molecules to complex biological systems", Liège, Belgium.

Kerff, F., Rocaboy, M., Herman, R., Sauvage, E., Moonens, K., Remaut, H., Charlier, P., & Terrak, M. (25 June 2012). Structure of the E. coli amidase AmiC and its activation by the LytM cofactor NlpD [Poster presentation]. Gordon Research Conference on bacterial Cell Surfaces, West Dover, VT, United States.

Kerff, F. (13 April 2010). OXA carbapenemase and their inhibition [Paper presentation]. 20th European Congress of Clinical Microbiology and Infectious Diseases, Vienne, Austria.

Kerff, F. (August 2008). Specific structural features of the N-acetylmuramyl-L-Alanine amidase AmiD from E.coli and general implication for the mechanism of action of this family of enzyme [Poster presentation]. XXI Congress and General Assembly of the International Union of Crystallography (IUCr), Osaka, Japan.

Kerff, F. (August 2006). Structure of the class D beta-lactamase OXA-29, a different carbonated dimer [Poster presentation]. 23rd European Crystallographic Meeting, Leuven, Belgium.

Kerff, F. (30 March 2002). The X-ray structure of the class D beta-lactamase OXA-2 from Salmonella typhymurium [Paper presentation]. The 8th Beta-Lactamase Workshop, Holy Island, United Kingdom.

Book chapters and contributions to collective works

Kerff, F., Sauvage, E., Vercheval, L., & Charlier, P. (2011). Structures of class D β-lactamases. In J.-M. Frère (Ed.), Beta-lactamases. Nova Science Publishers.

Other publications and communications

Speeches and writings for a general audience

Conferences given outside the academic context

Kerff, F. (2012). Cristallographie des protéines : principe de base et résultats [Paper presentation]. Mini-conférence -Société Royale des Sciences de Liège, Liège, Belgium.