Publications and communications of Mohammed Terrak

Dhehibi, A., Terrak, M., Seddik, M.-M., Hammadi, M., & Salhi, I. (March 2024). Development of a bispecific Nanobody anti-F17 fimbria as a potential therapeutic tool. Protein Expression and Purification, 215, 106411. doi:10.1016/j.pep.2023.106411

Dhehibi, A., Allaoui, A., Raouafi, A., Terrak, M., Bouhaouala-Zahar, B., Hammadi, M., Raouafi, N., & Salhi, I. (20 February 2023). Nanobody-Based Sandwich Immunoassay for Pathogenic Escherichia coli F17 Strain Detection. Biosensors, 13 (2), 299. doi:10.3390/bios13020299

Li, Y.* , Boes, A.* , Cui, Y., Zhao, S., Liao, Q., Gong, H., Breukink, E., Lutkenhaus, J., Terrak, M.* , & Du, S.*. (2022). Identification of the potential active site of the septal peptidoglycan polymerase FtsW. PLoS Genetics, 18 (1), 1009993. doi:10.1371/journal.pgen.1009993

Terrak, M., & Frère, J.-M. (2021). β‐Lactam Antibiotics. In S. Offermanns & W. Rosenthal (Eds.), Encyclopedia of Molecular Pharmacology (3rd ed. Encyclopedia of Molecular Pharmacology). Springer, Cham. doi:10.1007/978-3-030-21573-6_29-1

Boes, A., Brunel, J. M., Derouaux, A., Kerff, F., Bouhss, A., Touze, T., Breukink, E., & Terrak, M. (2020). Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b. Antibiotics. doi:10.3390/antibiotics9070373

Boes, A., Kerff, F., Herman, R., Touze, T., Breukink, E., & Terrak, M. (2020). Biochemical and structural insights into the activation of PBP1b by the essential domain of FtsN. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/248617.

Boes, A., Kerff, F., Herman, R., Touze, T., Breukink, E., & Terrak, M. (2020). The bacterial cell division protein fragment (E)FtsN binds to and activates the major peptidoglycan synthase PBP1b. Journal of Biological Chemistry, 295 (52), 18256-18265. doi:10.1074/jbc.RA120.015951

Boes, A., Olatunji, S., Mohammadi, T., Breukink, E., & Terrak, M. (2020). Fluorescence anisotropy assays for high throughput screening of compounds binding to lipid II, PBP1b, FtsW and MurJ. Scientific Reports, 10 (1), 6280. doi:10.1038/s41598-020-63380-2

Pazos, M., Peters, K., Boes, A., Safaei, Y., Kenward, C., Caveney, N. A., Laguri, C., Breukink, E., Strynadka, N. C. J., Simorre, J.-P., Terrak, M., & Vollmer, W. (2020). SPOR Proteins Are Required for Functionality of Class A Penicillin-Binding Proteins in Escherichia coli. MBio, 11 (6). doi:10.1128/mBio.02796-20

Boes, A., & Terrak, M. (December 2019). Biochemical and structural insights into the activation of PBP1b by the essential domain of FtsN [Poster presentation]. Symposium Currents trends in membrane protein biophysics.

Boes, A., Terrak, M., Kerff, F., Touzé, T., & Breukink, E. (15 November 2019). Biochemical and structural insights into the interaction of the essential domain of FtsN with PBP1b [Poster presentation]. SFMBBM.

Terrak, M. (11 June 2019). Regulation of the peptidoglycan synthases PBPs within the divisome [Paper presentation]. EMBO Workshop Bacterial cell division: Closing the gap, Lund, Sweden.

Boes, A., olatunji, S., Breukink, E., & Terrak, M. (08 January 2019). Regulation of the Peptidoglycan Polymerase Activity of PBP1b by Antagonist Actions of the Core Divisome Proteins FtsBLQ and FtsN. MBio, 10. doi:10.1128/mBio.01912-18

Terrak, M. (2019). Bacterial cell wall biosynthesis and regulation [Paper presentation]. Invitation de UM6P, Ben Guerir, Morocco.

Boes, A., & Terrak, M. (November 2018). Interaction and activities regulation within the septal peptidoglycan enzymatic core in E. coli [Poster presentation]. SFMBBM.

Dahmane, I., Montagner, C., Matagne, A., Dumbre, S., Herdewijn, P., & Terrak, M. (2018). Peptidoglycan glycosyltransferase-ligand binding assay based on tryptophan fluorescence quenching. Biochimie. doi:10.1016/j.biochi.2018.06.010

Boes, A., & Terrak, M. (December 2017). Study of the interactions and activities within the enzymatic core of the E. coli divisome [Paper presentation]. IPROS meeting.

Boes, A., & Terrak, M. (25 September 2017). Antagonist activities of the FtsQLB complex and FtsN on peptidoglycan synthesis suggests a regulation mechanism of the divisome [Poster presentation]. Greatwall symposium 2017.

Olatunji, S., & Terrak, M. (15 May 2017). Identification and characterization of interactions between MurJ (MviN) and proteins of bacterial division and elongation machineries in E. coli [Poster presentation]. Membrane Proteins: Structure & Function. Suzhou, China. May 15-19, 2017.

Leclercq, S., Derouaux, A., Olatunji, S., Fraipont, C., Egan, A. J. F., Vollmer, W., Breukink, E., & Terrak, M. (24 February 2017). Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis. Scientific Reports, 7, 43306. doi:10.1038/srep43306

Collienne, S., Mouithys-Mickalad, A., Terrak, M., & Hoebeke, M. (20 May 2016). Electron paramagnetic resonance and fluorescence studies on potential anticancer properties of two Ru(II) complexes [Poster presentation]. 24th Benelux EPR society Meeting, Liège, Belgium.

Sauvage, E., & Terrak, M. (17 February 2016). Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials. Antibiotics, 5 (1). doi:10.3390/antibiotics5010012

Sosic, I., Anderluh, M., Sova, M., Gobec, M., Mlinaric Rascan, I., Derouaux, A., Amoroso, A. M., Terrak, M., Breukink, E., & Gobec, S. (2015). Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5b01482

Leclercq, S., Olatunji, S., Derouaux, A., Breukink, E., & Terrak, M. (September 2015). In vitro reconstitution of multi-proteins complexes of the peptidoglycan synthesis machinery of Escherichia coli [Poster presentation]. 4th Great Wall Symposium, Florence, Italy.

Collienne, S., Terrak, M., Mouithys-Mickalad, A., Delaude, L., & Hoebeke, M. (22 May 2015). Electron paramagnetic resonance and fluorescence studies on potential anticancer properties of two new Ru(II) complexes : preliminary results [Poster presentation]. 23rd Benelux EPR Society Meeting, Ghent, Belgium.

Bury, D., Dahmane, I., Derouaux, A., Dumbre, S., Herdewijn, P., Matagne, A., Breukink, E., Mueller-Seitz, E., Petz, M., & Terrak, M. (2015). Positive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase. Biochemical Pharmacology, 93 (2), 141-50. doi:10.1016/j.bcp.2014.11.003

Derouaux, A., Terrak, M., Den Blaauwen, T., & Vollmer, W. (2014). Bacterial cell wall growth, shape and division. In Bacterial Membranes: Structural and Molecular Biology. Horizon Scientific Press.

Leclercq, S., Derouaux, A., & Terrak, M. (23 September 2013). Study of the activities of PBP3/PBP1b from Escherichia coli and the effect of the immediate divisome partners [Poster presentation]. The 3rd Great Wall Symposium “The Dynamics of Peptidoglycan Structure and Function: New Insights into the 'Great Wall', Paris, France.

Arguelles Arias, A., Ongena, M., Devreese, B., Terrak, M., Joris, B., & Fickers, P. (2013). Characterization of amylolysin, a novel lantibiotic from Bacillus amyloliquefaciens GA1. PLoS ONE, 8 (12). doi:10.1371/journal.pone.0083037

Derouaux, A., Sauvage, E., & Terrak, M. (2013). Peptidoglycan glycosyltransferase substrate mimics as templates for the design of new antibacterial drugs. Frontiers in Immunology, 4, 78. doi:10.3389/fimmu.2013.00078

Rocaboy, M., Herman, R., Sauvage, E., Remaut, H., Moonens, K., Terrak, M., Charlier, P., & Kerff, F. (2013). The crystal structure of the cell division amidase AmiC reveals the fold of the AMIN domain, a new peptidoglycan binding domain. Molecular Microbiology. doi:10.1111/mmi.12361

Terrak, M. (11 December 2012). Exploration of the Glycosyltransferases as new antibacterial target [Paper presentation]. Invited conference, Ljubljana, Slovenia.

Kerff, F., Rocaboy, M., Herman, R., Sauvage, E., Moonens, K., Remaut, H., Charlier, P., & Terrak, M. (25 June 2012). Structure of the E. coli amidase AmiC and its activation by the LytM cofactor NlpD [Poster presentation]. Gordon Research Conference on bacterial Cell Surfaces, West Dover, VT, United States.

Banzhaf, M., van den Berg van Saparoea, B., Terrak, M., Fraipont, C., Egan, A., Philippe, J., Zapun, A., Breukink, E., Nguyen-Distèche, M., den Blaauwen, T., & Vollmer, W. (2012). Cooperativity of peptidoglycan synthases active in bacterial cell elongation. Molecular Microbiology, 85 (1), 179-94. doi:10.1111/j.1365-2958.2012.08103.x

Dumbre, S., Derouaux, A., Lescrinier, E., Piette, A., Joris, B., Terrak, M., & Herdewijn, P. (2012). Synthesis of Modified Peptidoglycan Precursor Analogues for the Inhibition of Glycosyltransferase. Journal of the American Chemical Society. doi:10.1021/ja302099u

Terrak, M., Herdewijn, & Bumbre, S. (29 September 2011). Specificity of E. coli PBP1b for the substrate and inhibition of its GT activity [Paper presentation]. The 2d Great Wall Symposium “The Dynamics of Peptidoglycan Structure and Function: New Insights into the 'Great Wall', Lisbon, Portugal.

Terrak, M., Breukink, E., Gobec, S., Chopra, I., & Vernet, T. (26 May 2011). Tryptamine-derived compounds as antibacterial agents.

Derouaux, A., Turk, S., Olrichs, N. K., Gobec, S., Breukink, E., Amoroso, A. M., Offant, J., Bostock, J., Mariner, K., Chopra, I., Vernet, T., Zervosen, A., Joris, B., Frère, J.-M., Nguyen Van, M., & Terrak, M. (2011). Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor. Biochemical Pharmacology, 81 (9), 1098-105. doi:10.1016/j.bcp.2011.02.008

Reed, P., Veiga, H., Jorge, A. M., Terrak, M., & Pinho, M. G. (2011). Monofunctional transglycosylases are not essential for Staphylococcus aureus cell wall synthesis. Journal of Bacteriology, 193 (10), 2549-56. doi:10.1128/JB.01474-10

Offant, J., Terrak, M., Derouaux, A., Breukink, E., Nguyen Van, M., Zapun, A., & Vernet, T. (2010). Optimization of conditions for the glycosyltransferase activity of penicillin-binding protein 1a from Thermotoga maritima. FEBS Journal, 277 (20), 4290-8. doi:10.1111/j.1742-4658.2010.07817.x

Derouaux, A., Turk, S., Offant, J., Amoroso, A. M., Breukink, E., Bostock, J., Chopra, I., Zervosen, A., Joris, B., Nguyen Van, M., Vernet, T., Gobec, S., & Terrak, M. (November 2009). Identification and characterization of novel peptidoglycan glycosyltransferase inhibitors with antibacterial activity [Poster presentation]. Exploration and exploitation of bacterial cell wall biosynthesis, Warwick, United Kingdom.

Terrak, M. (15 December 2008). Penicillin-binding proteins: function in the bacterial cell wall assembly and their targeting with antibacterial agents [Paper presentation]. Invited conference, Varese, Italy.

Derouaux, A., Wolf, B., Fraipont, C., Breukink, E., Nguyen-Distèche, M., & Terrak, M. (March 2008). The Monofunctional Glycosyltransferase of Escherichia Coli Localizes to the Cell Division Site and Interacts with Penicillin-Binding Protein 3, FtsW, and FtsN. Journal of Bacteriology, 190 (5), 1831-4. doi:10.1128/JB.01377-07

Sauvage, E.* , Kerff, F.* , Terrak, M., Ayala, J. A., & Charlier, P. (March 2008). The Penicillin-Binding Proteins: Structure and Role in Peptidoglycan Biosynthesis. FEMS Microbiology Reviews, 32 (2), 234-58. doi:10.1111/j.1574-6976.2008.00105.x

Terrak, M. (2008). Peptidoglycan Glycosyltransferase Inhibition: New Perspectives for An Old Target. Anti-Infective Agents in Medicinal Chemistry. doi:10.2174/187152108784911241

Terrak, M., Sauvage, E., Derouaux, A., Dehareng, D., Bouhss, A., Breukink, E., Jeanjean, S., & Nguyen-Distèche, M. (2008). Importance of the conserved residues in the peptidoglycan glycosyltransferase module of the class A penicillin-binding protein 1b of Escherichia coli. Journal of Biological Chemistry, 283 (42), 28464-70. doi:10.1074/jbc.M803223200

Muller, P., Ewers, C., Bertsche, U., Anstett, M., Kallis, T., Breukink, E., Fraipont, C., Terrak, M., Nguyen-Distèche, M., & Vollmer, W. (14 December 2007). The essential cell division protein FtsN interacts with the murein (peptidoglycan) synthase PBP1B in Escherichia coli. Journal of Biological Chemistry, 282 (50), 36394-36402. doi:10.1074/jbc.M706390200

Terrak, M. (March 2007). Bacterial cell wall biosynthesis [Paper presentation]. The first international fungal/plant cell wall meeting: cell wall polysaccharides of fungi and plants, Biaritz, France.

Terrak, M., & Nguyen-Distèche, M. (April 2006). Kinetic characterization of the monofunctional glycosyltransferase from Staphylococcus aureus. Journal of Bacteriology, 188 (7), 2528-2532. doi:10.1128/JB.188.7.2528-2532.2006

Zawadzka-Skomial, J., Markiewicz, Z., Nguyen-Distèche, M., Devreese, B., Frère, J.-M., & Terrak, M. (March 2006). Characterization of the bifunctional glycosyltransferase/acyltransferase penicillin-binding protein 4 of Listeria monocytogenes. Journal of Bacteriology, 188 (5), 1875-1881. doi:10.1128/JB.188.5.1875-1881.2006

Terrak, M., Rebowski, G., Lu, R. C., Grabarek, Z., & Dominguez, R. (2005). Structure of the light chain-binding domain of myosin V. Proceedings of the National Academy of Sciences of the United States of America, 102 (36), 12718-23. doi:10.1073/pnas.0503899102

Rebowski, Terrak, M., Lu, R. C., Dominguez, R., & Grabarek. (January 2004). The Iq motif defines the conformation of the interacting calmodullin. Biophysical Journal, 86, 571A-571.

Terrak, M., Kerff, F., Langsetmo, K., Gong, B. J., Tao, T., & Dominguez, R. (2004). PP1 targeting and regulation as revealed by the structure of a PP1 delta-MYPT1 complex. Biophysical Journal, 86 (1), 172A-172.

Terrak, M.* , Kerff, F.* , Langsetmo, K., Tao, T., & Dominguez, R. (2004). Structural basis of protein phosphatase 1 regulation. Nature, 429 (6993), 780-4. doi:10.1038/nature02582

Terrak, M., Staford, W., & Lu, R. (2004). The neck domain of myosin V. Biophysical Journal, 86, 572A-572.

Terrak, M., Wu, G., Stafford, W. F., Lu, R. C., & Dominguez, R. (2003). Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications. EMBO Journal, 22 (3), 362-71. doi:10.1093/emboj/cdg058

Terrak, M., Otterbein, L. R., Wu, G., Palecanda, L. A., Lu, R. C., & Dominguez, R. (2002). Crystallization, X-ray characterization and selenomethionine phasing of Mlc1p bound to IQ motifs from myosin V. Acta Crystallographica. Section D, Biological Crystallography, 58 (Pt 10 Pt 2), 1882-5. doi:10.1107/S0907444902013951

Terrak, M. (2000). Structure-function relationship of the Escherichia coli PBP1B modules [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/188950

Terrak, M., Ghosh, T. K., van Heijenoort, J., Van Beeumen, J., Lampilas, M., Aszodi, J., Ayala, J. A., Ghuysen, J.-M., & Nguyen-Distèche, M. (October 1999). The Catalytic, Glycosyl Transferase and Acyl Transferase Modules of the Cell Wall Peptidoglycan-Polymerizing Penicillin-Binding Protein 1b of Escherichia Coli. Molecular Microbiology, 34 (2), 350-364. doi:10.1046/j.1365-2958.1999.01612.x

Goffin, C., Fraipont, C., Ayala, J., Terrak, M., Nguyen-Distèche, M., & Ghuysen, J.-M. (September 1996). The non-penicillin-binding module of the tripartite penicillin-binding protein 3 of Escherichia Coli is required for folding and/or stability of the penicillin-binding module and the membrane-anchoring module confers cell septation activity on the folded structure. Journal of Bacteriology, 178 (18), 5402-5409. doi:10.1128/jb.178.18.5402-5409.1996