Publications and communications of Sylvie Legrand

Wilkin, C., Piette, J., & Legrand, S. (October 2024). Unravelling metabolic factors impacting iNKT cell biology in obesity. Biochemical Pharmacology, 228, 116436. doi:10.1016/j.bcp.2024.116436

L'homme, L., Sermikli, B. P., Haas, J. T., Fleury, S., Quemener, S., Guinot, V., Barreby, E., Esser, N., Caiazzo, R., Verkindt, H., Legendre, B., Raverdy, V., Cheval, L., Paquot, N., Piette, J., Legrand, S., Aouadi, M., Pattou, F., Staels, B., & Dombrowicz, D. (21 August 2024). Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH. Nature Communications, 15 (1), 7173. doi:10.1038/s41467-024-51078-2

Iovino, M., Colonval, M., Wilkin, C., L'Homme, L., Lassence, C., Campas, M., Peulen, O., De Tullio, P., Piette, J., & Legrand, S. (2023). Novel XBP1s-independent function of IRE1 RNase in HIF-1α-mediated glycolysis upregulation in human macrophages upon stimulation with LPS or saturated fatty acid. Frontiers in Immunology. doi:10.3389/fimmu.2023.1204126

Wilkin, C., Esser, N., Paquot, N., & Legrand, S. (09 September 2022). Th2-skewing of human circulating iNKT cells in the context of obesity [Poster presentation]. Interuniversity PhD Student Day.

Iovino, M., Wilkin, C., Colonval, M., L'Homme, L., Campas, M., Schoumacher, M., De Tullio, P., Piette, J., & Legrand, S. (27 June 2022). IRE1 endoribonuclease plays a key role in activation of both HIF-1alpha and glucose metabolism in saturated fatty acid-treated human macrophages [Poster presentation]. Cell Symposium: Translational Immunometabolism, Bâle, Switzerland.

Wilkin, C., Esser, N., PAQUOT, N., & Legrand, S. (27 June 2022). Impact of obesity and glucose tolerance on human circulating iNKT cells [Poster presentation]. Cell Symposium Translational Immunometabolism 2022, Basel, Switzerland.

Wilkin, C., Esser, N., PAQUOT, N., & Legrand, S. (20 May 2022). Impact of obesity and glucose tolerance on human circulating iNKT cells [Paper presentation]. Belgian Association for the Study of Obesity: BASO, Bruxelles, Belgium.

Wilkin, C., Esser, N., PAQUOT, N., & Legrand, S. (08 April 2022). Impact of obesity and glucose tolerance on human circulating iNKT cells [Paper presentation]. Télévie Seminar, Liège, Belgium.

Wilkin, C., Colonval, M., Dehairs, J., Esser, N., Iovino, M., Gianfrancesco, M. A., FADEUR, M., Swinnen, J. V., PAQUOT, N., Piette, J., & Legrand, S. (2021). New insights on the PBMCs phospholipidome in obesity demonstrate modulations associated with insulin resistance and glycemic status. Nutrients. doi:10.3390/nu13103461

Wilkin, C., Colonval, M., Dehairs, J., Esser, N., Iovino, M., Gianfrancesco, M., FADEUR, M., Swinnen, J. V., PAQUOT, N., Piette, J., & Legrand, S. (01 September 2021). Modulation of the phospholipidome in circulating immune cells of obese patients are associated to insulin resistance or glycemic status [Poster presentation]. 6th European Congress of Immunology.

L'homme, L., Sermikli, B. P., Staels, B., Piette, J., Legrand, S.* , & Dombrowicz, D.*. (2020). Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway. Nutrients. doi:10.3390/nu12123771

Iovino, M., Paquot, N., & Legrand, S. (May 2019). Metabolic reprogramming of human monocytes/macrophages in obesity ; implications in obesity-linked inflammation and cancers [Poster presentation]. PhD Day 2019.

Gianfrancesco, M., Dehairs, J., L'homme, L., Herinckxe, G., Esser, N., Jansen, O., Habraken, Y., Lassence, C., Swinnen, J., Rider, M., Piette, J., PAQUOT, N., & Legrand, S. (April 2019). Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption. BBA - Molecular and Cell Biology of Lipids, 1864, 1017–1030. doi:10.1016/j.bbalip.2019.04.001

Iovino, M., Colonval, M., Paquot, N., & Legrand, S. (January 2019). Metabolic reprogramming of human monocytes/macrophages in obesity ; implications in obesity-linked inflammation and cancers [Poster presentation]. Télévie Cancer Seminar 2019.

Colonval, M., Iovino, M., Esser, N., Dehairs, J., Ehx, G., Baron, F., Piette, J., Swinnen, J., Paquot, N., & Legrand, S. (26 June 2018). Obesity induces metabolic and phenotypic variations in blood monocytes and NK cells [Poster presentation]. Cell Symposia: Translational Immunometabolism.

Colonval, M., Gouasmia, H., Fettweiss, G., Gianfrancesco, M., Dehairs, J., PAQUOT, N., Swinnen, J., Piette, J., & Legrand, S. (25 June 2018). Saturated fatty acid-treated human macrophages and obese adipose tissue macrophages exhibit similar metabolic reprogramming [Poster presentation]. Cell Symposium: Translational Immunometabolism.

Gianfrancesco, M., Paquot, N., Piette, J., & Legrand, S. (2018). Lipid bilayer stress in obesity-linked inflammatory and metabolic disorders. Biochemical Pharmacology. doi:10.1016/j.bcp.2018.02.022

Gianfrancesco, M., Dehairs, J., L’homme, L., Herinckx, G., Bloch, K., Piette, J., Rider, M., Swinnen, J., Paquot, N., Esser, N., & Legrand, S. (2018). La saturation des phospholipides membranaires induit un efflux de K+ et une activation de l’inflammasome NLRP3 dans des macrophages humains via l’intermédiaire de la Na, K-ATPase. Nutrition Clinique et Metabolisme, 32 (1), 38. doi:10.1016/j.nupar.2017.11.006

Colonval, M., Feitweiss, G., L'Homme, L., Piette, J., & Legrand, S. (26 October 2017). Investigation of the glycolytic switch induced by saturated fatty acid in human macrophages [Poster presentation]. Macrophage Biology in the Single-Cell Era, Ghent, Belgium.

Colonval, M., Fettweis, G., L'homme, L., Piette, J., & Legrand, S. (May 2017). Investigation of the glycolytic switch induced by saturated fatty acid in human macrophages [Poster presentation]. Keystone - Integrating metabolism and immunity joint with the meeting on cell death and inflammation, Dublin, Ireland.

Gianfrancesco, M., Dehairs, J., Bloch, K., L’homme, L., Jansen, O., Frederich, M., Piette, J., Swinnen, J., Paquot, N., Esser, N., & Legrand, S. (2017). Implication du remodelage de la membrane plasmique par les acides gras dans la régulation de l’activité de l’inflammasome NLRP3 dans des macrophages humains. Nutrition Clinique et Metabolisme, 31 (3), 255. doi:10.1016/j.nupar.2017.06.002

Gianfrancesco, M., Dehairs, J., L'Homme, L., Colonval, M., Piette, J., Swinnen, J., Paquot, N., Esser, N., & Legrand, S. (2017). The saturation of membrane phospholipids would be a trigger for K+ efflux and NLRP3 inflammasome activation in human monocytes/macrophages. Diabetologia.

Gianfrancesco, M., Dehairs, J., Bloch, K., L'Homme, L., Piette, J., Swinnen, J., Paquot, N., Esser, N., & Legrand, S. (12 September 2016). Involvement of membrane remodelling induced by fatty acids in the regulation of the NLRP3 inflammasome activity in human macrophages [Poster presentation]. 52nd Annual Meeting of the European Association for the Study od Diabetes, Munich, Germany.

Gianfrancesco, M., Dehairs, J., Bloch, K., L'homme, L., Piette, J., Swinnen, J., Paquot, N., Esser, N., & Legrand, S. (August 2016). Involvement of membrane remodelling induced by fatty acids in the regulation of the NLRP3 inflammasome activity in human macrophages. Diabetologia, 59 (Supplement 1), 291.

Gianfrancesco, M., Bloch, K., Dehairs, J., L'Homme, L., Swinnen, J., Piette, J., SCHEEN, A., Paquot, N., Legrand-Poels, S., & ESSER, N. (March 2016). Implication du remodelage membranaire induit par les acides gras dans la régulation de l’activité de l’inflammasome NLRP3 dans les macrophages humains [Paper presentation]. Congrès 2016 de la Société Francophone du Diabète, Lyon, France.

TIMA, H. G., AL DULAYYMI, J. A. R., DENIS, O., LEHEBEL, P., BAOLS, K. S., MOHAMMED, M. O., L’HOMME, L., SAHB, M. M., POTEMBERG, G., Legrand, S., LANG, R., BEYAERT, R., PIETTE, J., BAIRD, M. S., HUYGEN, K.* , & ROMANO, M.*. (2016). Inflammatory properties and adjuvant potential of synthetic glycolipids homologous to mycolate esters of the cell wall of Mycobacterium tuberculosis. Journal of Innate Immunity. doi:10.1159/000450955

Gianfrancesco, M., Bloch, K., Dehairs, J., L'Homme, L., Swinnen, J., Piette, J., PAQUOT, N., ESSER, N., & Legrand-Poels, S. (September 2015). Deciphering the molecular mechanisms underlying NLRP3 inflammasome activation by saturated fatty acids [Poster presentation]. 3rd International Conference on Immunometabolism: Molecular and Cellular Immunology of Metabolism, Chania, Greece.

Legrand-Poels, S., Esser, N., L'Homme, L., SCHEEN, A., PAQUOT, N., & Piette, J. (2014). Free fatty acids as modulators of the NLRP3 inflammasome in obesity / type 2 diabetes. Biochemical Pharmacology. doi:10.1016/j.bcp.2014.08.013

ESSER, N., Legrand-Poels, S., Piette, J., Paquot, N., & Scheen, A. (2014). Inflammasome NLRP3 et graisse viscerale. Revue Médicale de Liège, 69 Spec No, 57-61.

ESSER, N., Legrand, S., Piette, J., SCHEEN, A., & PAQUOT, N. (2014). Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Research and Clinical Practice. doi:10.1016/j.diabres.2014.04.006

ESSER, N., L'Homme, L., DE ROOVER, A., KOHNEN, L., SCHEEN, A., MOUTSCHEN, M., Piette, J., Legrand-Poels, S., & PAQUOT, N. (November 2013). Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue. Diabetologia, 56, 2487-2497. doi:10.1007/s00125-013-3023-9

L'Homme, L., Esser, N., Riva, L., Scheen, A., Paquot, N., Piette, J., & Legrand, S. (November 2013). Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages. Journal of Lipid Research, 54, 2998-3008. doi:10.1194/jlr.M037861

Esser, N., L'Homme, L., DE ROOVER, A., KOHNEN, L., SCHEEN, A., MOUTSCHEN, M., Piette, J., Legrand-Poels, S., & PAQUOT, N. (2013). Increased Inflammasome and Caspase-1 Activation in Visceral adipose tissue from Metabolically Unhealthy Obese compared to Metabolically Healthy Obese subjects. Diabetes, (62/suppl.1), 555.

Esser, N., L'Homme, L., DE ROOVER, A., KOHNEN, L., SCHEEN, A., Moutschen, M., Piette, J., Legrand-Poels, S., & PAQUOT, N. (March 2013). Différences d’activité de l’inflammasome NLRP3 entre sujets obèses avec et sans anomalies métaboliques. Diabetes and Metabolism, 39 (suppl 1), 102.

Esser, N., L'Homme, L., SCHEEN, A., MOUTSCHEN, M., Piette, J., PAQUOT, N., & Legrand, S. (January 2013). Differences in inflammasome activation between metabolically healthy and unhealthy obese individuals [Poster presentation]. Metabolic control of inflammation and immunity, Breckenridge, Colorado, United States.

L'Homme, L., Esser, N., PAQUOT, N., Piette, J., & Legrand, S. (January 2013). Unsaturated fatty acids inhibit saturated fatty acids-induced NLRP3 inflammasome activation [Poster presentation]. Keystone Symposia meeting on "Metabolic Control of Inflammation and Immunity", Breckenridge, Colorado, United States.

Condé, C., Rambout, X., Lebrun, M., Lecat, A., Di Valentin, E., Dequiedt, F., Piette, J., Gloire, G., & Legrand, S. (2012). The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-κB activation by disturbing the interaction of XIAP with RIP2. PLoS ONE. doi:10.1371/journal.pone.0041005

Lecat, A., Di Valentin, E., Somja, J., Jourdan, S., Fillet, M., Kufer, T., Habraken, Y., Sadzot-Delvaux, C., Louis, E., Delvenne, P., Piette, J., & Legrand-Poels, S. (2012). The c-jun N-terminal Kinase (JNK)-binding Protein (JNKBP1) Acts as a Negative Regulator of NOD2 Protein Signaling by Inhibiting Its Oligomerization Process. Journal of Biological Chemistry, 287 (35), 29213-26. doi:10.1074/jbc.M112.355545

Lecat, A., Di Valentin, E., Fillet, M., Piette, J., & Legrand-Poels, S. (27 January 2011). identification of new parterns of the NOD2 protein [Poster presentation]. cell signalomics 2011, Luxembourg, Luxembourg.

Lecat, A., Di Valentin, E., Fillet, M., Rambout, X., Twizere, J.-C., Dequiedt, F., Piette, J., & Legrand-Poels, S. (28 January 2010). NOD2 interactome [Poster presentation]. inflammation 2010, Luxembourg, Luxembourg.

Lecat, A., Piette, J., & Legrand-Poels, S. (2010). The protein Nod2: an innate receptor more complex than previously assumed. Biochemical Pharmacology, 80 (12), 2021-31. doi:10.1016/j.bcp.2010.07.016

Lecat, A., Di Valentin, E., Piette, J., & Legrand-Poels, S. (April 2009). identification of new parterns of the NOD2 protein in an invasion model of intestinal epithelial cells by salmonella typhimurium [Poster presentation]. Biomedica, Liège, Belgium.

Kustermans, G., Piette, J., & Legrand, S. (01 December 2008). Actin-targeting natural compounds as tools to study the role of actin cytoskeleton in signal transduction. Biochemical Pharmacology, 76(11), 1310-1322. doi:10.1016/j.bcp.2008.05.028

Kustermans, G., El Mjiyad, N., Horion, J., Jacobs, N., Piette, J., & Legrand-Poels, S. (2008). Actin cytoskeleton differentially modulates NF-κB-mediated IL-8 expression in myelomonocytic cells. Biochemical Pharmacology, 76(10), 1214-1228. doi:10.1016/j.bcp.2008.08.017

Legrand, S., Kustermans, G., Bex, F., Kufer, T., Kremmer, E., & Piette, J. (01 April 2007). Modulation of Nod2-dependent NF-kappa B signaling by the actin cytoskeleton. Journal of Cell Science, 120 (7), 1299-1310. doi:10.1242/jcs.03424

Gloire, G., Legrand-Poels, S., & Piette, J. (30 November 2006). NF-kappa B activation by reactive oxygen species: Fifteen years later. Biochemical Pharmacology, 72 (11), 1493-1505. doi:10.1016/j.bcp.2006.04.011

Kustermans, G., El Benna, J., Piette, J., & Legrand, S. (15 April 2005). Perturbation of actin dynamics induces NF-kappa B activation in myelomonocytic cells through an NADPH oxidase-dependent pathway. Biochemical Journal, 387 (Pt 2), 531-540. doi:10.1042/BJ20041318

Nys, M., Deby, G., Habraken, Y., Legrand-Poels, S., Kohnen, S., Ledoux, D., Canivet, J.-L., Damas, P., & Lamy, M. (2003). Bronchoalveolar lavage fluids of ventilated patients with acute lung injury activate NF-kB in alveolar epithelial cell line: role of reactive oxygen/nitrogen species and cytokines. Nitric Oxide, 9 (1), 33-43. doi:10.1016/j.niox.2003.07.001

Viatour, P., Legrand-Poels, S., Van Lint, C., Warnier, M., Merville, M.-P., Gielen, J., Piette, J., BOURS, V., & Chariot, A. (2003). Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histones deacetylases (HDAC1 and HDAC3). Journal of Biological Chemistry.

Nys, M., Deby-Dupont, G., Habraken, Y., Legrand-Poels, S., Ledoux, D., CANIVET, J.-L., Damas, P., & Lamy, M. (December 2002). Bronchoalveolar lavage fluids of patients with lung injury activate the transcription factor nuclear factor-kappa beta in an alveolar cell line. Clinical Science, 103 (6), 577-585. doi:10.1042/cs1030577

Legrand-Poels, S., Schoonbroodt, S., & Piette, J. (2000). Regulation of interleukin-6 gene expression by pro-inflammatory cytokines in a colon cancer cell line. Biochemical Journal. doi:10.1042/bj3490765

Schoonbroodt, S., Ferreira, V., Best-Belpomme, M., Boelaert, J. R., Legrand-Poels, S., Korner, M., & Piette, J. (2000). Crucial role of the amino-terminal tyrosine residue 42 and the carboxy-terminal PEST domain of IkappaBalpha in NF-kappaB activation by an oxidative stress. Journal of Immunology. doi:10.4049/jimmunol.164.8.4292

JOSSE, C., Legrand-Poels, S., Piret, B., Sluse, F., & Piette, J. (1998). Impairment of the mitochondrial electron chain transport prevents NF-kappa B activation by hydrogen peroxide. Free Radical Biology and Medicine, 25 (1), 104-112. doi:10.1016/S0891-5849(98)00057-4

Josse, C., Legrand-Poels, S., Piret, B., Sluse, F., & Piette, J. (1998). Impairment of mitochondrial functions abolishes NF-kappaB activation by an oxidative stress. Free Radical Biology and Medicine.

Legrand-Poels, S., Schoonbroodt, S., Matroule, J.-Y., & Piette, J. (1998). NF-kappaB: an important transcription factor in photobiology. Journal of Photochemistry and Photobiology B: Biology. doi:10.1016/S1011-1344(98)00118-3

Edeas, M., Arbault, S., Legrand-Poels, S., Sojic, N., Amatore, C., Piette, J., Best-Belpomme, M., Lindenbaum, A., & Vuillaume, M. (1997). Phenylarsine oxide inhibits ex vivo HIV-1 expression. Biomedicine and Pharmacotherapy. doi:10.1016/S0753-3322(97)82321-9

Legrand-Poels, S., Maniglia, S., Boelaert, J. R., & Piette, J. (1997). Activation of the transcription factor NF-kappaB in lipopolysaccharide-stimulated U937 cells. Biochemical Pharmacology. doi:10.1016/S0006-2952(96)00715-0

Legrand-Poels, S., Zecchinon, L., Piret, B., Schoonbroodt, S., & Piette, J. (1997). Involvement of different transduction pathways in NF-kappaB activation by several inducers. Free Radical Research. doi:10.3109/10715769709065768

Schoonbroodt, S., Legrand-Poels, S., Best-Belpomme, M., & Piette, J. (1997). Hypochlorous acid activates NF-kappaB transcription factor in T lymphocytes. Biochemical Journal.

Legrand-Poels, S., Bours, V., Piret, B., Pflaum, M., Epe, B., Rentier, B., & Piette, J. (24 March 1995). Transcription factor NF-kB is activated by photosensitization generating oxidative DNA damages. Journal of Biological Chemistry, 270 (12), 6925-6934. doi:10.1074/jbc.270.12.6925

Piette, J., Legrand-Poels, S., & Piret, B. (1995). HIV-1 and NF-kappaB activation by photo-oxidative stress. Photochemistry and Photobiology.

Piret, B., Legrand-Poels, S., Sappey, C., & Piette, J. (1995). NF-kappaB transcription factor and human immunodeficiency virus type 1 (HIV-1) are activated by methylene blue photosensitization. European Journal of Biochemistry. doi:10.1111/j.1432-1033.1995.tb20283.x

Sappey, C., Boelaert, J. R., Legrand-Poels, S., Forceille, C., Favier, A., & Piette, J. (1995). Iron chelation decreases NF-kappaB and HIV-1 activation due to oxidative stress. AIDS Research and Human Retroviruses. doi:10.1089/aid.1995.11.1049

Sappey, C., Boelaert, J. R., Legrand-Poels, S., Grady, R. W., & Piette, J. (1995). NF-kappaB transcription factor activation by hydrogen peroxide can be decreased by 2,3-dihydroxybenzoic acid and its ethylester derivative. Archives of Biochemistry and Biophysics. doi:10.1006/abbi.1995.1394

Sappey, C., Legrand, S., Best-Belpomme, M., Favier, A., Rentier, B., & Piette, J. (1994). Stimulation of glutatione-peroxidase activity decreases HIV type-1 activation after oxidative stress. AIDS Research and Human Retroviruses, 10 (11), 1451-1461. doi:10.1089/aid.1994.10.1451

Legrand, S., Hoebeke, M., Vaira, D., Rentier, B., & Piette, J. (March 1993). HIV-1 promoter activation following an oxidative stress mediated by singlet oxygen. Journal of Photochemistry and Photobiology B: Biology, 17 (3), 229-237. doi:10.1016/1011-1344(93)80020-A

Piette, J., & Legrand-Poels, S. (1993). Intracellular damages induced by singlet oxygen are signals for HIV-1 reactivation. Journal of Free Radicals in Biology and Medicine.

Legrand, S., Hoebeke, M., Vaira, D., Rentier, B., Van de Vorst, A., & Piette, J. (1992). HIV-1 reactivation after an oxidative stress. Archives Internationales de Physiologie, de Biochimie et de Biophysique, 100, 55.

Legrand, S., Vaira, D., Rentier, B., & Piette, J. (1992). HIV-1 reactivation after an oxidative stress. In LinkVIII International Conference on AIDS/III STD World Congress, Amsterdam, the Netherlands 19-24 July 1992. Amsterdam, Netherlands: CONGREX Holland B.V.

Legrand-Poels, S., VAIRA, D., PINCEMAIL, J., Van de Vorst, A., & Piette, J. (1990). Activation of human immunodeficiency virus type 1 by an oxidative stress. AIDS Research and Human Retroviruses. doi:10.1089/aid.1990.6.1389