Publications and communications of Emmanuel Dejardin

Beauvois, A.* , Gazon, H.* , Chauhan, P. S., Jamakhani, M., Jacques, J.-R., Thiry, M., Dejardin, E., Di Valentin, E., Twizere, J.-C., Péloponèse, J.-M., Njock, M.-S., Yasunaga, J.-I., Matsuoka, M., Hamaïdia, M.* , & Willems, L.*. (2023). The helicase-like transcription factor redirects the autophagic flux and restricts human T-cell leukemia virus type 1 infection. Proceedings of the National Academy of Sciences of the United States of America, 120 (31), 2216127120. doi:10.1073/pnas.2216127120
* These authors have contributed equally to this work.

Lion, Q., Wen, X., Shostak, K., Vanleyssem, R., Close, P., Dejardin, E., & Chariot, A. (06 September 2022). ROLE OF THE tRNA-MODIFYING ENZYME ELONGATOR IN LIVER. Poster session presented at GIGA DAY 2022.

Faure-Dupuy, S., Riedl, T., Rolland, M., Hizir, Z., Reisinger, F., Neuhaus, K., Schuehle, S., Remouchamps, C., Gillet, N., Schönung, M., Stadler, M., Wettengel, J., Barnault, R., Parent, R., Schuster, L. C., Farhat, R., Prokosch, S., Leuchtenberger, C., Öllinger, R., ... Heikenwälder, M.*. (December 2021). Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p. JHEP Reports, 3 (6), 100354. doi:10.1016/j.jhepr.2021.100354
* These authors have contributed equally to this work.

Riedl, T., Faure-Dupuy, S., Rolland, M., Schuehle, S., Hizir, Z., Calderazzo, S., Zhuang, X., Wettengel, J., Lopez, M., Barnault, R., Mirakaj, V., Prokosch, S., Heide, D., Leuchtenbergeg, C., Schneider, M., Heßling, B., Stottmeier, B., Wessbecher, I. M., Schirmacher, P., ... Heikenwalder, M. (2021). HIF1α-mediated RelB/APOBEC3B downregulation allows Hepatitis B Virus persistence. Hepatology (Baltimore, Md.). doi:10.1002/hep.31902

Conlon, T., John-Schuster, G., Heide, D., Pfister, D., Lehmann, M., Hu, Y., Ertuz, Z., Lopez, M., Ansari, M., Strunz, M., Mayr, C., Cimineiri, C., Costa, R., Kohlhepp, M. S., Guillot, A., Günes, G., Jeridi, A., Funk, M., Beroshvili, G., ... Yildirim, A. Ö. (2020). Inhibition of LTβR-signalling activates Wnt-induced regeneration in lung. Nature. doi:10.1038/s41586-020-2882-8

Namineni, S., O'Connor, T., Faure-Dupuy, S., Johansen, P., Riedl, T., Liu, K., Xu, H., Singh, I., Shinde, P., Li, F., Pandyra, A., Sharma, P., Ringelhan, M., Muschaweckh, A., Borst, K., Blank, P., Lampl, S., Durantel, D., Farhat, R., ... Heikenwalder, M. (2020). A dual role for hepatocyte-intrinsic canonical NF-kappaB signaling in virus control. Journal of Hepatology. doi:10.1016/j.jhep.2019.12.019

Seleznik, G. M., Reding, T., Peter, L., Gupta, A., Steiner, S. G., Sonda, S., Verbeke, C. S., Dejardin, E., Khatkov, I., Segerer, S., Heikenwalder, M., & Graf, R. (2018). Development of autoimmune pancreatitis is independent of CDKN1A/p21-mediated pancreatic inflammation. Gut. doi:10.1136/gutjnl-2016-313458

Tanghe, G., Urwyler-Rosselet, C., De Groote, P., Dejardin, E., De Bock, P.-J., Gevaert, K., Vandenabeele, P., & Declercq, W. (2018). RIPK4 activity in keratinocytes is controlled by the SCF(beta-TrCP) ubiquitin ligase to maintain cortical actin organization. Cellular and Molecular Life Sciences. doi:10.1007/s00018-018-2763-6

Boege, Y., Malehmir, M., Healy, M. E., Bettermann, K., Lorentzen, A., Vucur, M., Ahuja, A. K., Bohm, F., Mertens, J. C., Shimizu, Y., Frick, L., Remouchamps, C., Mutreja, K., Kahne, T., Sundaravinayagam, D., Wolf, M. J., Rehrauer, H., Koppe, C., Speicher, T., ... Weber, A. (2017). A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development. Cancer Cell, 32 (3), 342-359.e10. doi:10.1016/j.ccell.2017.08.010

Fernandes, M. T., Dejardin, E., & Santos, N. R. D. (2016). Context-dependent roles for lymphotoxin-beta receptor signaling in cancer development. Biochimica et Biophysica Acta. doi:10.1016/j.bbcan.2016.02.005

Boutaffala, L., Bertrand, M. J. M., Remouchamps, C., Seleznik, G., Reisinger, F., Janas, M., Benezech, C., Fernandes, M. T., Marchetti, S., Mair, F., Ganeff, C., Hupalowska, A., Ricci, J.-E., Becher, B., Piette, J., Knolle, P., Caamano, J., Vandenabeele, P., Heikenwalder, M., & Dejardin, E. (December 2015). NIK promotes tissue destruction independently of the alternative NF-kappaB pathway through TNFR1/RIP1-induced apoptosis. Cell Death and Differentiation, 10.1038/cdd.2015.69. doi:10.1038/cdd.2015.69

Fernandes, M. T., Ghezzo, M. N., Silveira, A. B., Kalathur, R. K., Povoa, V., Ribeiro, A. R., Brandalise, S. R., Dejardin, E., Alves, N. L., Ghysdael, J., Barata, J. T., Yunes, J. A., & Dos Santos, N. R. (2015). Lymphotoxin-beta receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype. British Journal of Haematology. doi:10.1111/bjh.13760

Singh, P.* , Dejager, L.* , Amand, M.* , Theatre, E., Vandereyken, M., Zurashvili, T., Singh, M., Mack, M., Timmermans, S., Musumeci, L., Dejardin, E., Mustelin, T., Van Ginderachter, J. A., Moutschen, M., Oury, C., Libert, C., & Rahmouni, S. (15 May 2015). DUSP3 genetic deletion confers M2-like−macrophage-dependent tolerance to septic shock. Journal of Immunology, 194 (10), 4951-62. doi:10.4049/jimmunol.1402431
* These authors have contributed equally to this work.

Chau, T.-L., Göktuna, S., Rammal, A., Casanova Bustos, T. R., Duong, H. Q., GATOT, J.-S., Close, P., Dejardin, E., Desmecht, D., Shostak, K., & Chariot, A. (2015). A role for APPL1 in tlr3/4-dependent TBK1 and IKKε activation in macrophages. Journal of Immunology. doi:10.4049/jimmunol.1401614

Dondelinger, Y., Jouan-Lanhouet, S., Divert, T., Théâtre, E., Bertin, J., Gough, P. J., Giansanti, P., Heck, A. J. R., Dejardin, E., Vandenabeele, P., & Bertrand, M. J. M. (2015). NF-kappaB-Independent Role of IKKalpha/IKKbeta in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling. Molecular Cell. doi:10.1016/j.molcel.2015.07.032

Remouchamps, C., & Dejardin, E. (2015). Methods to Assess the Activation of the Alternative (Noncanonical) NF-kappaB Pathway by Non-death TNF Receptors. In NF-kappa B: Methods and Protocols (pp. 103-19). United States: Michael J May (ed.). doi:10.1007/978-1-4939-2422-6_7

Dejardin, E. (05 November 2014). Discovery of new E3 ligases for the alternative NF-κB pathway. Paper presented at First Proteostasis meeting of the COST Action BM1307, Valencia, Spain.

Lucifora, J., Xia, Y., Reisinger, F., Zhang, K., Stadler, D., Cheng, X., Sprinzl, M. F., Koppensteiner, H., Makowska, Z., Volz, T., Remouchamps, C., Chou, W.-M., Thasler, W. E., Huser, N., Durantel, D., Liang, T. J., Munk, C., Heim, M. H., Browning, J. L., ... Protzer, U. (14 March 2014). Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA. Science, 343. doi:10.1126/science.1243462

Gray, C. M., Remouchamps, C., McCorkell, K. A., Solt, L. A., Dejardin, E., Orange, J. S., & May, M. J. (2014). Noncanonical NF-kappaB Signaling Is Limited by Classical NF-kappaB Activity. Science Signaling, 7 (311), 13. doi:10.1126/scisignal.2004557

Dejardin, E. (08 November 2013). Pro-death function of the NIK kinase in TNF-α-induced thymic involution. Paper presented at BIS Annual Meeting, Liège, Belgium.

Dondelinger, Y., Aguileta, M., Goosens, V., Dubuisson, C., Grootjans, S., Dejardin, E., Vandenabeele, P., & Bertrand, M. (20 October 2013). RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition. Cell Death and Differentiation, 10, 1381-92. doi:10.1038/cdd.2013.94

Dejardin, E. (01 October 2012). Discovery of new E3 ligases for the control of the alternative NF-kB pathway. Paper presented at NF-kB subunit workshop, Rauischholzhausen, Germany.

Ganeff, C., Remouchamps, C., Boutaffala, L., Benezech, C., Galopin, G., Vandepaer, S., Bouillenne, F., Ormenese, S., Chariot, A., Schneider, P., Caamano, J., Piette, J., & Dejardin, E. (30 November 2011). Induction of the Alternative NF-{kappa}B Pathway by Lymphotoxin {alpha}{beta} (LT{alpha}{beta}) Relies on Internalization of LT{beta} Receptor. Molecular and Cellular Biology, 21, 4319-4334. doi:10.1128/MCB.05033-11

Boutaffala, L., Bertrand, M., Remouchamps, C., Ganeff, C., Marchetti, S., Vandenabeele, P., Piette, J., Caamano, J., Heikenwalder, M., & Dejardin, E. (2011). The hidden function of NIK (NF-κB-Inducing Kinase) in cell death. Paper presented at 13th International TNF Conference, Awaji island, Japan.

Remouchamps, C., Boutaffala, L., Ganeff, C., & Dejardin, E. (2011). Biology and Signal Transduction pathways of the Lymphotoxin-αβ/LTβR system. Cytokine and Growth Factor Reviews, 22, 301-310. doi:10.1016/j.cytogfr.2011.11.007

Boutafalla, L., Bertrand, M., Remouchamps, C., Ganeff, C., Marchetti, S., Ricci, J.-E., Piette, J., Caamano, J., Vandenabeele, P., Heihenwalder, M., & Dejardin, E. (2010). TNFR-induced activation of MAP3K14/NIK enhances TNFR1-induced cell death. Paper presented at 18th Euroconference on Apoptosis (ECDO), Gent, Belgium.

Dejardin, E. (2010). Interplay between non-death and death TNFR in inflammation. Paper presented at 6th CCN meeting, Newcastle, Ireland.

Ganeff, C., Galopin, G., Remouchamps, C., Benezech, C., Boutaffala, L., de trez, C., Bouillenne, F., Ormenese, S., CHARIOT, A., Norris, P., Ware, C., Schneider, P., Caamano, J., Piette, J., & Dejardin, E. (January 2010). TNFL–Induced p100 processing (TIPP) relies on the internalization of the cognate TNFR. Paper presented at Inflammation 2010, Luxembourg, Luxembourg.

Mortier, J., Frederick, R., Ganeff, C., Remouchamps, C., Talaga, P., Pochet, L., Wouters, J., Piette, J., Dejardin, E., & Masereel, B. (2010). Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-kappaB activation. Biochemical Pharmacology, 79 (10), 1462-72. doi:10.1016/j.bcp.2010.01.007

Dejardin, E., Droin, N., Delhase, M., Haas, E., Cao, Y., Makris, C., Li, Z.-W., Karin, M., Ware, C., & Green, D. (30 October 2009). The lymphotoxin-β receptor induces different patterns of gene expression via two NF-κB pathways. Paper presented at TNF Superfamily Conference 2002, San Diego, United States.

Robert, I., Aussems, M., Keutgens, A., Zhang-Shao, X., Hennuy, B., Viatour, P., Vanstraelen, G., Merville, M.-P., Chapelle, J.-P., de Leval, L., LAMBERT, F., Dejardin, E., Gothot, A., & Chariot, A. (02 April 2009). Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-κB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes. Oncogene, 28 (13), 1626-1638. doi:10.1038/onc.2009.6

Goval, J.-J., Thielen, C., Bourguignon, C., Greimers, R., Dejardin, E., Choi, Y. S., Boniver, J., & de Leval, L. (August 2008). The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP. Haematologica, 93 (8), 1169-77. doi:10.3324/haematol.12127

Cornez, I., Creppe, C., Gillard, M., Hennuy, B., Chapelle, J.-P., Dejardin, E., Merville, M.-P., Close, P., & Chariot, A. (June 2008). Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells. Biochemical Pharmacology, 75, 2122-2134. doi:10.1016/j.bcp.2008.03.006

Gioia, R., GATOT, J.-S., Chau, T.-L., Warnier, M., Chapelle, J.-P., Piette, J., Dejardin, E., & Chariot, A. (December 2007). Insight into the TBK1/IKK-dependent signalling pathways required in innate immunity through identification of the TANK/I-TRAF interactome. Poster session presented at Journée Télévie, ULB GOsselies, Belgium.

GATOT, J.-S., Gioia, R., Chau, T.-L., Patrascu, F. A., Warnier, M., Close, P., Chapelle, J.-P., Muraille, E., Brown, K., Siebenlist, U., Piette, J., Dejardin, E., & Chariot, A. (26 October 2007). Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKK epsilon-dependent lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF. Journal of Biological Chemistry, 282 (43), 31131-31146. doi:10.1074/jbc.M701690200

Lambert, C., Oury, C., Dejardin, E., Chariot, A., Piette, J., Malaise, M., Merville, M.-P., & Franchimont, N. (September 2007). Further insights in the mechanisms of interleukin-1beta stimulation of osteoprotegerin in osteoblast-like cells. Journal of Bone and Mineral Research, 22 (9), 1350-1361. doi:10.1359/jbmr.070508

Gloire, G., Horion, J., El Mjiyad, N., Bex, F., Chariot, A., Dejardin, E., & Piette, J. (20 July 2007). Promoter-dependent effect of IKK alpha on NF-kappa B/p65 DNA binding. Journal of Biological Chemistry, 282 (29), 21308-21318. doi:10.1074/jbc.M610728200

GATOT, J.-S., Gioia, R., Chau, T.-L., Warnier, M., Chapelle, J.-P., Merville, M.-P., Brown, K., Siebenlist, U., Muraille, E., Dejardin, E., Piette, J., & Chariot, A. (March 2007). Polyubiquitination of the scaffold protein tank/I-traf: implications for the TLR-mediated signalling pathways. Poster session presented at Colloque "Chromatin Dynamics and Epigenetics" Société belge de biologie cellulaire et du développement, Liège, Belgium.

El Mjiyad, N., Bontems, S., Gloire, G., Horion, J., Vandevenne, P., Dejardin, E., Piette, J., & Sadzot-Delvaux, C. (2007). Varicella-zoster virus modulates NF-kappaB recruitment on selected cellular promoters. Journal of Virology, 81 (23), 13092-104. doi:10.1128/JVI.01378-07

Dejardin, E. (30 October 2006). The alternative NF-kappa B pathway from biochemistry to biology: Pitfalls and promises for future drug development [letter to the editor]. Biochemical Pharmacology, 72 (9), 1161-1179. doi:10.1016/j.bcp.2006.08.007

Gloire, G., Dejardin, E., & Piette, J. (30 October 2006). Extending the nuclear roles of I kappa B kinase subunits. Biochemical Pharmacology, 72 (9), 1081-1089. doi:10.1016/j.bcp.2006.06.017

Maurer, U., Charvet, C., Wagman, A., Dejardin, E., & Green, D. (17 March 2006). Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Molecular Cell, 21 (6), 749-760. doi:10.1016/j.molcel.2006.02.009

Viatour, P., Dejardin, E., Warnier, M., Lair, F., Claudio, E., Bureau, F., Marine, J. C., Merville, M.-P., Maurer, U., Green, D., Piette, J., Siebenlist, U., Bours, V., & Chariot, A. (08 October 2004). GSK3-Mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. Molecular Cell, 16 (1), 35-45. doi:10.1016/j.molcel.2004.09.004

Droin, N., Pinkoski, M., Dejardin, E., & Green, D. (November 2003). Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses. Molecular and Cellular Biology, 23 (21), 7638-7647. doi:10.1128/MCB.23.21.7638-7647.2003

Derudder, E., Dejardin, E., Pritchard, L. L., Green, D. R., Korner, M., & Baud, V. (2003). RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100. Journal of Biological Chemistry, 278 (26), 23278-84. doi:10.1074/jbc.M300106200

Dejardin, E., Droin, N., Delhase, M., Haas, E., Cao, Y., Makris, C., Li, Z.-W., Karin, M., Ware, C., & Green, D. (October 2002). The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity, 17, 525-535. doi:10.1016/S1074-7613(02)00423-5

Dejardin, E., Droin, N., Delhase, M., Hass, E., Cao, Y., Makris, C., Li, Z.-W., Karin, M., Ware, C., & Green, D. (2002). The lymphotoxin-β receptor induces different patterns of gene expression via two NF-κB pathways. Paper presented at TNF Superfamily Conference 2002, San Diego, United States.

Dejardin, E., Haas, E., Ware, C., & Green, D. (09 November 2001). IKKα and IKKβ have different roles in LTβR-mediated NF-κB activation. Paper presented at e Cytokine Odyssey 2001, Maui, United States - Hawaii.

Bentires-Alj, M., Dejardin, E., Viatour, P., Van Lint, C., Froesch, B., Reed, J. C., Merville, M.-P., & Bours, V. (11 May 2001). Inhibition of the Nf-Kappa B Transcription Factor Increases Bax Expression in Cancer Cell Lines. Oncogene, 20 (22), 2805-13. doi:10.1038/sj.onc.1204343

Dejardin, E., Deregowski, V., Chapelier, M., Jacobs, N., Gielen, J., Merville, M.-P., & Bours, V. (22 April 1999). Regulation of Nf-Kappab Activity by I Kappab-Related Proteins in Adenocarcinoma Cells. Oncogene, 18 (16), 2567-77. doi:10.1038/sj.onc.1202599

Dejardin, E., Deregowski, V., GREIMERS, R., Cai, Z., Chouaib, S., Merville, M.-P., & BOURS, V. (1998). Regulation of major histocompatibility complex class I expression by NF-kB-related proteins in breast cancer cells. Oncogene. doi:10.1038/sj.onc.1201879

Bonizzi, G., Dejardin, E., Piret, B., Piette, J., Merville, M.-P., & Bours, V. (15 December 1996). Interleukin-1 Beta Induces Nuclear Factor Kappa B in Epithelial Cells Independently of the Production of Reactive Oxygen Intermediates. European Journal of Biochemistry, 242 (3), 544-9. doi:10.1111/j.1432-1033.1996.0544r.x

Dejardin, E., Bonizzi, G., Bellahcene, A., Castronovo, V., Merville, M.-P., & Bours, V. (02 November 1995). Highly-Expressed P100/P52 (Nfkb2) Sequesters Other Nf-Kappa B-Related Proteins in the Cytoplasm of Human Breast Cancer Cells. Oncogene, 11 (9), 1835-41.

Bours, V., Dejardin, E., Goujon-Letawe, F., Merville, M.-P., & Castronovo, V. (13 January 1994). The Nf-Kappa B Transcription Factor and Cancer: High Expression of Nf-Kappa B- and I Kappa B-Related Proteins in Tumor Cell Lines. Biochemical Pharmacology, 47 (1), 145-9. doi:10.1016/0006-2952(94)90448-0

Bours, V., Azarenko, V., Dejardin, E., & Siebenlist, U. (1994). Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins. Oncogene, 9 (6), 1699-702.