Publications and communications of Patrice CHIAP

Koch, N., Jennotte, O., Lechanteur, A., DEVILLE, M., Charlier, C., Cardot Jean-Michel, CHIAP, P., & Evrard, B. (2024). An Intravenous Pharmacokinetic Study of Cannabidiol Solutions in Piglets through the Application of a Validated Ultra-High-Pressure Liquid Chromatography Coupled to Tandem Mass Spectrometry Method for the Simultaneous Quantification of CBD and Its Carboxylated Metabolite in Plasma. Pharmaceutics. doi:10.3390/pharmaceutics16010140

Koch, N., Jennotte, O., Bourcy, Q., Lechanteur, A., Chiap, P., & Evrard, B. (2023). How the choice of dissolution parameters influences the interpretation of dissolution efficiency from two different cannabidiol formulations? [Poster presentation]. 4th European Conference on Pharmaceutics, Marseille, France.

Lecomte, F.* , Aerts, J.* , Plenevaux, A., Defraiteur, C., Chappuis-Hugon, F., Rozet, E., CHIAP, P., Luxen, A., Pichon, V., Hubert, P.* , & Hubert, C.*. (20 February 2020). Performance evaluation of a MIP for the MISPE-LC determination of p-[18F]MPPF and a potential metabolite in human plasma. Journal of Pharmaceutical and Biomedical Analysis, 180. doi:10.1016/j.jpba.2019.113015
* These authors have contributed equally to this work.

Legrand, N., Tian, J., Douny, C., Scippo, M.-L., Cambier, C., Fillet, M., Chiap, P., Dubrowski, T., Vandeweerd, J., & Gustin, P. (26 October 2018). Triamcinolone acetonide after intra-articular injection in knee in sheep [Poster presentation]. Proceedings of the 5th FARAH-Day, Liège, Belgium.

CHIAP, P., Van Heugen, J.-C., Dubrowski, T., DEVILLE, M., DUBOIS, N., & De Tullio, P. (19 October 2017). Utilisation de la Résonance Magnétique Nucléaire (RMN) pour la caractérisation de métabolites et de produits de dégradation de médicaments [Paper presentation]. 6èmes Journées Internationales de Toxicologie, Liège, Belgium.

Dubrowski, T., PINCEMAIL, J., Vigor, C., Durand, T., Bertrand-Michel, J., Donneau, A.-F., Van Heugen, J.-C., Defraigne, J.-O., Charlier, C., & CHIAP, P. (October 2017). Validation d’une méthode UHPLC/MS-MS pour le dosage plasmatique du 15-F2t-isoprostane, biomarqueur du stress oxydant, en vue de l’établissement de valeurs de référence en routine clinique [Poster presentation]. 6èmes Journées Internationales de Toxicologie, Liège, Belgium.

PINCEMAIL, J., Dubrowski, T., Durand, T., CHIAP, P., CHARLIER, C., Donneau, A.-F., Bertrand-Michel, J., Dupuy, A., Vigor, C., Van Heugen, J.-C., & Defraigne, J.-O. (June 2017). Validated routine-ready UHPLC/MS-MS method for the reference range determination in human plasma of 15-f2t-isoprostane, biomarker of the oxidative stress. Free Radical Biology and Medicine, 108, 42. doi:10.1016/j.freeradbiomed.2017.04.157

Farcas, E., Servais, A.-C., Lamalle, C., CHIAP, P., Pochet, L., & Fillet, M. (01 October 2016). OPTIMIZATION OF A FULLY AUTOMATED ELECTROPHORETICALLY MEDIATED MICROANALYSIS SYSTEM FOR CYP1A1 ACTIVITY MONITORING [Paper presentation]. The 16th Edition of National Congress of Pharmacy in Romania, Bucharest, Romania.

CHIAP, P. (01 June 2016). Mise en place d’études cliniques portant sur des antioxydants [Paper presentation]. StressOX, Modulation du stress oxydant : Nouveaux concepts pour de nouvelles applications, Romainville, France.

Farcas, E., Servais, A.-C., Lamalle, C., CHIAP, P., Pochet, L., & Fillet, M. (2016). Fully automated electrophoretically mediated microanalysis for CYP1A1 activity monitoring optimized by multivariate approach. Electrophoresis, 37 (2), 248-255. doi:10.1002/elps.201500214

Farcas, E., Servais, A.-C., Lamalle, C., Chiap, P., Pochet, L., & Fillet, M. (08 September 2015). OPTIMIZATION OF A FULLY AUTOMATED ELECTROPHORETICALLY MEDIATED MICROANALYSIS SYSTEM FOR CYP1A1 ACTIVITY MONITORING [Poster presentation]. UniGR workshop: From drug target to drug development.

Farcas, E., Servais, A.-C., Lamalle, C., Chiap, P., Pochet, L., & Fillet, M. (23 June 2015). FULLY AUTOMATED ELECTROPHORETICALLY MEDIATED MICROANALYSIS SYSTEM FOR CYP1A1 ACTIVITY MONITORING [Poster presentation]. HPLC 2015, Geneva, Switzerland.

Farcas, E., Servais, A.-C., Lamalle, C., Chiap, P., Pochet, L., & Fillet, M. (28 May 2015). Fully automated electrophoretically mediated microanalysis system for CYP1A1 activity monitoring [Paper presentation]. THE 18th FORUM OF PHARMACEUTICAL SCIENCES, Blankenberge, Belgium.

Dupuy, A., Pinot, E., Vigor, C., Oger, C., Galano, J.-M., PINCEMAIL, J., Dubrowski, T., Van Heugen, J.-C., CHIAP, P., Dray, C., Le Faouder, P., Durand, T., & Bertrand-Michel, J. (September 2014). An HPLC-MS method for the analysis of 26 non-enzymatic metabolites of PUFAs in biological samples [Poster presentation]. 7th HNE-Club International Meeting - 5th Food Health Symposium / SAS 2014, Toulouse, France.

LAMBERT, V., Dufour, G., Chiap, P., Evrard, B., Noël, A., Pirotte, B., & De Tullio, P. (23 June 2014). NMR in the Pharmaceutical and Biomedical areas for identification and quantification of drugs and metabolomics applications [Paper presentation]. Drug Analysis 2014, Liège, Belgium.

Farcas, E., Servais, A.-C., Lamalle, C., CHIAP, P., & Fillet, M. (22 June 2014). DEVELOPMENT OF AN ELECTROPHORETICALLY MEDIATED MICROANALYSIS FOR THE IN-LINE METABOLISM STUDY OF 7-ETHOXYCOUMARIN [Poster presentation]. 10th International Symposium on Drug Analysis - 25th International Symposium on Pharmaceutical and Biomedical Analysis, Liege, Belgium.

Sacre, P.-Y., Deconinck, E., Marini Djang'Eing'A, R., Ziemons, E., Hubert, P., CHIAP, P., Crommen, J., & De Beer, J. O. (May 2014). Stratégies analytiques pour la détection de contrefaçons de médicaments pour la dysfonction érectile. Spectra Analyse, 43, 37.

Constant-Urban, C., Charif, M., Goffin, E., VAN HEUGEN, J.-C., Elmoualij, B., CHIAP, P., Mouithys-Mickalad, A., Serteyn, D., Lebrun, P., Pirotte, B., & De Tullio, P. (2013). Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels. Bioorganic and Medicinal Chemistry Letters, 23, 5878-5881. doi:10.1016/j.bmcl.2013.08.091

Dossou, K. S. S., Farcas, E., Servais, A.-C., CHIAP, P., Chankvetadze, B., Crommen, J., & Fillet, M. (2012). Optimization of the liquid chromatography enantioseparation of chiral acidic compounds using cellulose tris(3-chloro-4-methylphenylcarbamate) as chiral selector and polar organic mobile phases. Journal of Chromatography. A, 1234, 56-63. doi:10.1016/j.chroma.2012.01.072

Rocks, N., Bekaert, S., Coia, I., Paulissen, G., Guéders, M., Evrard, B., VAN HEUGEN, J.-C., CHIAP, P., Foidart, J.-M., Noël, A., & Cataldo, D. (2012). Curcumin-cyclodextrin complexes potentiate gemcitabine effects in an orthotopic mouse model of lung cancer. British Journal of Cancer, 107 (7), 1083-92. doi:10.1038/bjc.2012.379

Sacré, P.-Y., Deconinck, E., Daszykowski, M., Courselle, P., Vancauwenberghe, R., Chiap, P., Crommen, J., & De Beer, J. (September 2011). Impurity fingerprints for the identification of counterfeit medicines - a feasibility study [Poster presentation]. Recent Developments in Pharmaceutical Analysis (RDPA), Pavie, Italy.

Mansion, F., Chiap, P., Houbart, V., Crommen, J., Servais, A.-C., & Fillet, M. (July 2011). Optimization of micro-HPLC peak focusing for the detection and quantification of low hepcidin concentrations. Journal of Separation Science, 34 (15), 1820-1827. doi:10.1002/jssc.201100244

Sacré, P.-Y., deconinck, E., Daszykowski, M., Courselle, P., Vancauwenberghe, R., Chiap, P., Crommen, J., & De Beer, J. (22 June 2011). Impurity fingerprints for the identification of counterfeit medicines - a feasibility study [Poster presentation]. HPLC 2011, Budapest, Hungary.

Sacré, P.-Y., Deconinck, E., Chiap, P., Crommen, J., Mansion, F., Rozet, E., Courselle, P., & De Beer, J. (20 June 2011). Development and validation of a UHPLC-UV method for the detection and quantification of erectile dysfunction drugs and some of their analogues found in counterfeit medicines [Poster presentation]. HPLC 2011, Budapest, Hungary.

Sacré, P.-Y., Deconinck, E., Saerens, L., De Beer, T., Courselle, P., Vancauwenberghe, R., Chiap, P., Crommen, J., & De Beer, J. (13 May 2011). Detection of counterfeit Viagra by Raman microspectroscopy imaging and multivariate analysis [Paper presentation]. 15ème Forum des Sciences Pharmaceutiques, Spa, Belgium.

Bimazubute, M., Cambier, C., Baert, K., Vanbelle, S., Chiap, P., & Gustin, P. (2011). Penetration of oxytetracycline into the nasal secretions and relationship between nasal secretions and plasma oxytetracycline concentrations after oral and intramuscular administration in healthy pigs. Journal of Veterinary Pharmacology and Therapeutics, 34 (2), 176-183. doi:10.1111/j.1365-2885.2010.01210.x

De Tullio, P., Servais, A.-C., Fillet, M., Gillotin, F., Somers, F., CHIAP, P., Lebrun, P., & Pirotte, B. (2011). Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-Isopropylamino-4H-1,2,4- benzothiadiazine 1,1-dioxides: Toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability. Journal of Medicinal Chemistry, 54, 8353-8361. doi:10.1021/jm200786z

Dossou, K. S. S., Chiap, P., Chankvetadze, B., Servais, A.-C., Fillet, M., & Crommen, J. (2011). LC enantioseparation of basic pharmaceuticals using chlorine containing cellulose based chiral stationary phases and polar organic mobile phases [Paper presentation]. Recent Development in Pharmaceutical Analysis (RDPA), Pavia, Italy.

Dossou, K. S. S., CHIAP, P., Servais, A.-C., Fillet, M., & Crommen, J. (2011). Evaluation of chlorine containing cellulose-based chiral stationary phases for the LC enantioseparation of basic pharmaceuticals using polar non-aqueous mobile phases. Journal of Separation Science, 34 (6), 617-22. doi:10.1002/jssc.201000774

Dossou, K. S. S., CHIAP, P., Servais, A.-C., Fillet, M., & Crommen, J. (2011). Development and validation of a LC method for the enantiomeric purity determination of S-ropivacaine in a pharmaceutical formulation using a recently commercialized cellulose-based chiral stationary phase and polar non-aqueous mobile phase. Journal of Pharmaceutical and Biomedical Analysis, 54 (4), 687-93. doi:10.1016/j.jpba.2010.10.020

Dossou, K. S. S., Edorh, P. A., Chiap, P., Chankvetadze, B., Servais, A.-C., Fillet, M., & Crommen, J. (2011). Determination of enantiomeric purity of S-amlodipine by chiral LC with emphasis on reversal of enantiomer elution order. Journal of Separation Science, 34, 1772-1780. doi:10.1002/jssc.201100339

Martin, G., Mansion, F., Houbart, V., PAQUET, P., RORIVE, A., CHIAP, P., Crommen, J., Servais, A.-C., & Fillet, M. (2011). Pre-study and in-study validation of a SPE-LC-MS-MS method for the determination of 5-S-cysteinyldopa, a melanoma biomarker, in human plasma. Talanta, 84 (2), 280-6. doi:10.1016/j.talanta.2010.12.047

Rousseau, A., Gillotin, F., Chiap, P., Bodoki, E., Crommen, J., Fillet, M., & Servais, A.-C. (2011). Generic systems for the enantioseparation of basic drugs in NACE using single-isomer anionic CDs. Journal of Pharmaceutical and Biomedical Analysis, 54, 154-159. doi:10.1016/j.jpba.2010.08.004

Sacré, P.-Y., Deconinck, E., Chiap, P., Crommen, J., Mansion, F., Rozet, E., Courselle, P., & De Beer, J. (2011). Development and validation of a ultra-high-performance liquid chromatography-UV method for the detection and quantification of erectile dysfunction drugs and some of their analogues found in counterfeit medicines. Journal of Chromatography. A, 1218, 6439-6447. doi:10.1016/j.chroma.2011.07.029

Sacré, P.-Y., Deconinck, E., Daszykowski, M., Courselle, P., Vancauwenberghe, R., Chiap, P., Crommen, J., & De Beer, J. (2011). Impurity fingerprints for the identification of counterfeit medicines - a feasibility study. Analytica Chimica Acta, 701, 224-231. doi:10.1016/j.aca.2011.05.041

Sacré, P.-Y.* , Deconinck, E.* , Saerens, L., De Beer, T., Courselle, P., Vancauwenberghe, R., Chiap, P., Crommen, J., & De Beer, J. (2011). Detection of counterfeit Viagra® by Raman Microspectroscopy imaging and multivariate analysis. Journal of Pharmaceutical and Biomedical Analysis, 56, 454-461. doi:10.1016/j.jpba.2011.05.042
* These authors have contributed equally to this work.

Servais, A.-C., Rousseau, A., CHIAP, P., Fillet, M., & Crommen, J. (2011). Determination of drug enantiomers in various matrices by non-aqueous capillary electrophoresis (NACE) [Paper presentation]. 23rd International Symposium on Pharmaceutical and Biomedical Analysis (PBA), Joao Pessoa PB, Brazil.

Sacré, P.-Y., Deconinck, E., De Beer, T., Courselle, P., Vancauwenberghe, R., Chiap, P., Crommen, J., & De Beer, J. (23 September 2010). Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines [Poster presentation]. Drug Analysis 2010, Anvers, Belgium.

Rousseau, A., Florence, X., Pirotte, B., Varenne, A., Gareil, P., Villemin, D., Chiap, P., Crommen, J., Fillet, M., & Servais, A.-C. (March 2010). Development and validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of a synthetic intermediate of new R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans using a single-isomer anionic cyclodextrin derivative and an ionic liquid [Poster presentation]. 25th International Symposium on MicroScale Bioseparations (MSB 2010), Prague, Czechia.

Rousseau, A., Gillotin, F., Chiap, P., Crommen, J., Servais, A.-C., & Fillet, M. (March 2010). Association of two single-isomer anionic CDs in NACE for the chiral and achiral separation of fenbendazole, its sulphoxide and sulphone metabolites: Application to their determination after in vitro metabolism [Poster presentation]. 25th International Symposium on MicroScale Bioseparations (MSB 2010), Prague, Czechia.

Bimazubute, M., Cambier, C., Baert, K., Vanbelle, S., Chiap, P., Albert, A., Delporte, J.-P., & Gustin, P. (2010). Penetration of enrofloxacin into the nasal secretions and relationship between nasal secretions and plasma enrofloxacin concentrations after intramuscular administration in healthy pigs. Journal of Veterinary Pharmacology and Therapeutics, 33 (2), 183-188. doi:10.1111/j.1365-2885.2009.01123.x

Crommen, J., Rousseau, A., Fradi, I., CHIAP, P., Fillet, M., & Servais, A.-C. (2010). Selective determination of drug enantiomers by non-aqueous capillary electrophoresis [Paper presentation]. 14th National Congress of Pharmacy (CNFR), Targu-Mures, Romania.

Dossou, K. S. S., Chiap, P., Chankvetadze, B., Servais, A.-C., Fillet, M., & Crommen, J. (2010). Optimization of the LC enantioseparation of chiral pharmaceuticals using cellulose tris(4-chloro-3-methylphenylcarbamate) as chiral selector and polar non-aqueous mobile phases. Journal of Separation Science, 33, 1699-1707. doi:10.1002/jssc.201000049

Francotte, P., Goffin, E., Fraikin, P., Lestage, P., Van Heugen, J.-C., Gillotin, F., Danober, L., Thomas, J.-Y., Chiap, P., Caignard, D.-H., Pirotte, B., & De Tullio, P. (2010). New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors. Journal of Medicinal Chemistry, 53, 1700-1711. doi:10.1021/jm901495t

Gillotin, F., Chiap, P., Frederich, M., Van Heugen, J.-C., Francotte, P., Lebrun, P., Pirotte, B., & De Tullio, P. (2010). Coupling of Liquid Chromatography/Tandem Mass Spectrometry and Liquid Chromatography/Solid-Phase Extraction/NMR Techniques for the Structural Identification of Metabolites following In Vitro Biotransformation of SUR1-Selective ATP-Sensitive Potassium Channel Openers. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 38 (2), 232-240. doi:10.1124/dmd.109.028928

Rousseau, A., Florence, X., Pirotte, B., Varenne, A., Gareil, P., Villemin, D., Chiap, P., Crommen, J., Fillet, M., & Servais, A.-C. (2010). Development and validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of a synthetic intermediate of new 3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans using a single-isomer anionic cyclodextrin derivative and an ionic liquid. Journal of Chromatography. A, 1217 (51), 7949-55. doi:10.1016/j.chroma.2010.07.005

Rousseau, A., Gillotin, F., Chiap, P., Crommen, J., Fillet, M., & Servais, A.-C. (2010). Association of two single-isomer anionic CD in NACE for the chiral and achiral separation of fenbendazole, its sulphoxide and sulphone metabolites: Application to their determination after in vitro metabolism. Electrophoresis, 31, 1482-1487. doi:10.1002/elps.200900723

Sacré, P.-Y., Deconinck, E., De Beer, T., Courselle, P., Vancauwenberghe, R., Chiap, P., Crommen, J., & De Beer, J. (2010). Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines. Journal of Pharmaceutical and Biomedical Analysis, 53, 445-453. doi:10.1016/j.jpba.2010.05.012

Francotte, P., Fraikin, P., Goffin, E., Danober, L., Lestage, P., Caignard, D. H., Lesur, B., Botez, I., Van Heugen, J.-C., Chiap, P., Pirotte, B., & De Tullio, P. (May 2009). Stabilisation métabolique par introduction d’atomes de fluor : application aux benzothiadiazine 1,1-dioxydes agissant en tant que potentialisateurs AMPA [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Dintilhac, G., Florence, X., Guillotin, F., Chiap, P., Lebrun, P., Pirotte, B., & De Tullio, P. (28 April 2009). Synthèse, étude de la métabolisation et évaluation pharmacologique du 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxyde (BPDZ 73) et de ses métabolites [Paper presentation]. Forum des jeunes chercheurs du CIRM, Liège, Belgium.

Bimazubute, M. A., Rozet, E., Dizier, I., Van Heugen, J.-C., Arancio, E., Gustin, P., Crommen, J., & Chiap, P. (2009). Pre-study and in-study validation of an ultra-high pressure LC method coupled to tandem mass spectrometry for off-line determination of oxytetracycline in nasal secretions of healthy pigs. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877 (23), 2349-57. doi:10.1016/j.jchromb.2009.01.033

Bimazubute, M., Rozet, E., Van Heugen, J.-C., Hubert, P., Gustin, P., & Chiap, P. (2009). Dosage d'oxytétracycline dans les secrétions nasales de porcs par chromatographie liquide : comparaison d'associations de méthodes de préparations d'échantillons et de modes de détection [Poster presentation]. 8e cognrès francophone de l'AFSEP sur les sciences séparatives et couplages, Marseille, France.

Dossou, K. S. S., Chiap, P., Chankvetadze, B., Servais, A.-C., Crommen, J., & Fillet, M. (2009). Evaluation of recently developed cellulose based chiral stationary phases for the LC enantioseparation of basic pharmaceuticals using polar non-aqueous mobile phases [Poster presentation]. 34th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2009), Dresden, Germany.

Dossou, K. S. S., Chiap, P., Chankvetadze, B., Servais, A.-C., Fillet, M., & Crommen, J. (2009). Enantioresolution of basic pharmaceuticals using cellulose tris(4-chloro-3-methylphenylcarbamate) as chiral stationary phase and polar organic mobile phases. Journal of Chromatography. A, 1216 (44), 7450-5. doi:10.1016/j.chroma.2009.05.081

Rousseau, A., Chiap, P., Oprean, R., Crommen, J., Fillet, M., & Servais, A.-C. (2009). Effect of the nature of the single-isomer anionic cyclodextrin and the BGE composition on the enantiomeric separation of β-blockers in nonaqueous capillary electrophoresis [Poster presentation]. 34th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2009), Dresden, Germany.

Rousseau, A., Chiap, P., Oprean, R., Crommen, J., Fillet, M., & Servais, A.-C. (2009). Effect of the nature of the single-isomer anionic CD and the BGE composition on the enantiomeric separation of beta-blockers in NACE. Electrophoresis, 30 (16), 2862-8. doi:10.1002/elps.200800824

Servais, A.-C., Rousseau, A., CHIAP, P., Fradi, I., Fillet, M., & Crommen, J. (2009). Recent developments in enantioseparations of acidic and basic drug compounds by non-aqueous capillary electrophoresis using charged cyclodextrins as chiral selectors [Paper presentation]. 20th International Symposium on Pharmaceutical and Biomedical Analysis (PBA), Agra, India.

Bimazubute, M. A., Rozet, E., Dizier, I., Gustin, P., Hubert, P., Crommen, J., & Chiap, P. (2008). Liquid chromatographic determination of enrofloxacin in nasal secretions and plasma of healthy pigs using restricted access material for on-line sample clean-up. Journal of Chromatography. A, 1189 (1-2), 456-466. doi:10.1016/j.chroma.2007.11.011

Dossou, K. S. S., Chiap, P., Servais, A.-C., Fillet, M., & Crommen, J. (2008). Comparison of different cellulose based chiral stationary phases for the LC enantioseparation of basic drugs using polar organic mobile phases [Paper presentation]. 19th International Symposium on pharmaceutical and biomedical analysis (PBA 2008), Gdansk, Poland.

Dossou, K. S. S., Chiap, P., Servais, A.-C., Fillet, M., & Crommen, J. (2008). A screening study of chiral pharmaceuticals using tris(4-chloro-3-methylphenylcarbamate) of cellulose-based stationary phase and polar organic mobile phases [Poster presentation]. 33rd International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2008), Kyoto, Japan.

Rousseau, A., Chiap, P., Ivanyi, R., Crommen, J., Fillet, M., & Servais, A.-C. (2008). Validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of R-flurbiprofen using a single-isomer amino cyclodextrin derivative. Journal of Chromatography. A, 1204 (2), 219-225. doi:10.1016/j.chroma.2008.06.006

Rousseau, A., Chiap, P., Ivanyi, R., Crommen, J., Fillet, M., & Servais, A.-C. (2008). Validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of R-flurbiprofen using a single-isomer amino cyclodextrin derivative [Poster presentation]. 22nd International Symposium on MicroScale Bioseparations (MSB 2008), Berlin, Germany.

Rousseau, A., Pedrini, M., Chiap, P., Ivanyi, R., Crommen, J., Fillet, M., & Servais, A.-C. (2008). Determination of flurbiprofen enantiomers in plasma using a single-isomer amino cyclodextrin derivative in nonaqueous capillary electrophoresis. Electrophoresis, 29 (17), 3641-8. doi:10.1002/elps.200700919

Rozet, E., Dewé, W., Morello, R., Chiap, P., Lecomte, F., Ziemons, E., Boos, K. S., Boulanger, B., Crommen, J., & Hubert, P. (2008). Risk-Based Approach for the Transfer of Quantitative Methods: Bioanalytical Applications. Journal of Chromatography. A, 1189, 32-41. doi:10.1016/j.chroma.2007.11.029

Francotte, P., Gillotin, F., Van Heuguen, J. C., Frederich, M., Lebrun, P., CHIAP, P., Pirotte, B., & De Tullio, P. (October 2007). Application of LC-SPE-NMR to the structural determination of metabolites of KATP channel openers belonging to 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Hubert, P., Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Chiap, P., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Lallier, M., Laurentie, M., Mercier, N., Muzard, G., Nivet, C., Valat, L., & Rozet, E. (21 September 2007). Harmonization of strategies for the validation of quantitative analytical procedures - A SFSTP proposal - Part II. Journal of Pharmaceutical and Biomedical Analysis, 45 (1), 70-81. doi:10.1016/j.jpba.2007.06.013

Lecomte, F., Aerts, J., Plenevaux, A., Lignon, S., Chapuis-Hugon, F., Chiap, P., Crommen, J., Luxen, A., Pichon, V., & Hubert, P. (September 2007). PPERFORMANCE EVALUATION OF TWO MIPS FOR THE SPE-LC-UV DETERMINATION OF p-[18F]MPPF IN PLASMA [Poster presentation]. RDPA 2007, 12th Internatioinal Meeting on Recent Developments in Pharmaceutical Analysis, Island of Elba, Italy.

Hubert, C., streel, B., Sibenaler, R., Chiap, P., & Hubert, P. (July 2007). Development and pre-validation of a high sensitive method for the determination of levonorgestrel in human plasma by SPE/LC/MS-MS [Poster presentation]. 31th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Gand, Belgium.

Lecomte, F., Aerts, J., Plenevaux, A., Lignon, S., Denjean, C., Chapuis-Hugon, F., Chiap, P., Crommen, J., Luxen, A., Pichon, V., & Hubert, P. (June 2007). DEVELOPMENT AND VALIDATION OF A METHOD FOR THE LC DETERMINATION p-[18F]MPPF IN PLASMA USING A MISPE [Poster presentation]. HPLC 2007 - 31st International Symposium on High Performance Liquid Phase Separations and Related Techniques, Ghent, Belgium.

Marini Djang'Eing'A, R., Servais, A.-C., Rozet, E., Chiap, P., Boulanger, B., Rudaz, S., Crommen, J., Hubert, P., & Fillet, M. (June 2007). Enantiomeric purity testing of S-timolol by non-aqueous CE using heptakis(2,3-di-O-methyl-6-O-Sulfo)-β-cyclodextrin as chiral additive – Validation using the accuracy profile strategy and estimation of uncertainty [Poster presentation]. 31st International Symposium on HPLC and Related techniques, Gand, Belgium.

Dewé, W., Govaerts, B., Boulanger, B., Rozet, E., Chiap, P., & Hubert, P. (15 February 2007). Using total error as decision criterion in analytical method transfer. Chemometrics and Intelligent Laboratory Systems, 85 (2), 262-268. doi:10.1016/j.chemolab.2006.07.003

Francois, Y., Varenne, A., Juillerat, E., Servais, A.-C., Chiap, P., & Gareil, P. (05 January 2007). Nonaqueous capillary electrophoretic behavior of 2-aryl propionic acids in the presence of an achiral ionic liquid - A chemometric approach. Journal of Chromatography. A, 1138 (1-2), 268-275. doi:10.1016/j.chroma.2006.10.063

Dossou, K. S. S., Chiap, P., Servais, A.-C., Fillet, M., & Crommen, J. (2007). HPLC enantioseparations of basic drugs using recently developed polysaccharide based chiral stationary phases and polar organic mobile phases [Paper presentation]. 12th International meeting on recent developments in pharmaceutical analysis (RDPA 2007), Elba, Italy.

Dossou, K. S. S., Ghiani, S., Chiap, P., Servais, A.-C., Fillet, M., & Crommen, J. (2007). HPLC enantioseparation of basic pharmaceuticals using a new polysaccharide based chiral stationary phase and non-aqueous polar mobile phases [Poster presentation]. 31st International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2007), Ghent, Belgium.

Gillotin, F., De Tullio, P., VAN HEUGEN, J.-C., Francotte, P., Frederich, M., Lebrun, P., Kremers, P., Pirotte, B., & CHIAP, P. (2007). Coupling of the LC-MS/MS and the LC-SPE-NMR for the structural identification of pancreatic KATP channel openers metabolites following in vitro biotransformation [Poster presentation]. HPLC 2007, Gent, Belgium.

Lecomte, F., Aerts, J., Houbart, V., Plenevaux, A., Lignon, S., Chiap, P., Crommen, J., Luxen, A., Pichon, V., & Hubert, P. (2007). EVALUATION DE DEUX POLYMERES A EMPREINTES MOLECULAIRES POUR LE DOSAGE DU p-[18F]MPPF DANS LE PLASMA [Poster presentation]. 7ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages - SEP07, Grenoble, France.

Martin, G., Chiap, P., Paquet, P., Pierard, G., De Tullio, P., Martin, Y., Rozet, E., Hubert, P., Crommen, J., & Fillet, M. (2007). Development of a mass spectrometry method for the determination of a melanoma biomarker, 5-S-cysteinyldopa, in human plasma using solid phase extraction for sample clean-up. Journal of Chromatography. A, 1156 (1-2), 141-8. doi:10.1016/j.chroma.2006.12.088

Rousseau, A., Pedrini, M., Chiap, P., Fillet, M., Crommen, J., & Servais, A.-C. (2007). Determination of flurbiprofen enantiomers in plasma using a single-isomer amino cyclodextrin derivative in non-aqueous capillary electrophoresis [Poster presentation]. 31st International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2007), Ghent, Belgium.

Rozet, E., Dewe, W., Govaerts, B., Boulanger, B., Ceccato, A., Chiap, P., Crommen, J., & Hubert, P. (2007). Evaluation of Analytical Method Transfer on a Risk Based Methodology using Total Error [Paper presentation]. HPLC.

Rozet, E., Dewe, W., Morello, R., Chiap, P., Ziemons, E., Boos, K. S., Boulanger, B., & Hubert, P. (2007). GESTION DU RISQUE LORS DU TRANSFERT DE METHODES ANALYTIQUES – CAS D’UNE METHODE BIOANALYTIQUE [Paper presentation]. SEP07.

Rozet, E., Morello, R., Lecomte, F., Martin, G. B., Chiap, P., Crommen, J., Boos, K.-S., & Hubert, P. (05 December 2006). Performances of a multidimensional on-line SPE-LC-ECD method for the determination of three major catecholamines in native human urine: Validation, risk and uncertainty assessments. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 844 (2), 251-260. doi:10.1016/j.jchromb.2006.07.060

De Tullio, P., Chiap, P., Francotte, P., Van Heugen, J.-C., Florence, X., Frederich, M., Gillotin, F., Kremers, P., Lebrun, P., & Pirotte, B. (18 November 2006). In vitro metabolisation study of several 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers : combined use of LC-Q-TOF MS/MS and LC-SPE-NMR [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Tullio, P., Frederich, M., Chiap, P., Kremers, P., Francotte, P., Lebrun, P., & Pirotte, B. (17 November 2006). Application of LC-SPE-NMR to the structural determination of KATP channel openers metabolites belonging to the 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxide derivatives [Paper presentation]. 5th YBMRS, Bruxelles, Belgium.

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Rudaz, S., Rozet, E., Crommen, J., & Hubert, P. (November 2006). Comparaison de trois approches pour l'estimation de l'incertitude [Paper presentation]. 3ème journée internationale de toxicologie hospitalière, Liège, Belgium.

Rozet, E., Mertens, B., Dewé, W., Ceccato, A., Govaerts, B., Boulanger, B., Chiap, P., Streel, B., Crommen, J., & Hubert, P. (11 September 2006). The transfer of a LC-UV method for the determination of fenofibrate and fenofibric acid in Lidoses: Use of total error as decision criterion. Journal of Pharmaceutical and Biomedical Analysis, 42 (1), 64-70. doi:10.1016/j.jpba.2005.12.037

Fradi, I.* , Servais, A.-C.* , Pedrini, M., Chiap, P., Ivanyi, R., Crommen, J., & Fillet, M. (September 2006). Enantiomeric separation of acidic compounds using single-isomer amino cyclodextrin derivatives in nonaqueous capillary electrophoresis. Electrophoresis, 27 (17), 3434-3442. doi:10.1002/elps.200500643
* These authors have contributed equally to this work.

Lecomte, F., Aerts, J., Plenevaux, A., Lignon, S., Haber, G., Boulanger, B., Chiap, P., Luxen, A., & Hubert, P. (September 2006). EVALUATION OF MOLECULARLY IMPRINTED POLYMERS BY MEANS OF EXPERIMENTAL DESIGN PRIOR TO THE DETERMINATION OF p-[18F]MPPF IN PLASMA [Poster presentation]. MIP2006 - Fourth International Workshop on Molecularly Imprinted Polymers, Cardiff, United Kingdom.

De Tullio, P., Gillotin, F., Francotte, P., Van Heugen, J.-C., Frederich, M., Lebrun, P., Chiap, P., & Pirotte, B. (August 2006). Combined use of LC-SPE-NMR and LC-MS for the metabolites characterization of ATP-sensitive potassium channel openers belonging to 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Poster presentation]. XIXth International Symposium on Medicinal Chemistry, Istanbul, Turkey.

De Tullio, P., Chiap, P., Francotte, P., Van Heugen, J.-C., Florence, X., Frederich, M., Gillotin, F., Kremers, P., Lebrun, P., & Pirotte, B. (June 2006). Application de la LC-SPE-RMN et de la LC-MS à la détermination structurale des métabolites d’activateurs des canaux KATP de la classe des 3-alkylamino-4H-arylthiadiazine 1,1-dioxydes [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Piette, M., Evrard, B., Frankenne, F., Chiap, P., Bertholet, P., Castagne, D., Foidart, J.-M., Delattre, L., & Piel, G. (June 2006). Pharmacokinetic study of a new synthetic MMP inhibitor (Ro 28-2653) after IV and oral administration of cyclodextrin solutions. European Journal of Pharmaceutical Sciences, 28 (3), 189-195. doi:10.1016/j.ejps.2006.01.011

Gillotin, F., De Tullio, P., Van Heugen, J.-C., Francotte, P., Frederich, M., Lebrun, P., Kremers, P., Chiap, P., & Pirotte, B. (17 May 2006). Application of LC-SPE-NMR and LC-Q-TOF MS/MS to the structural determination of KATP channel openers metabolites belonging to the 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Poster presentation]. 10th Bioforum, Liège, Belgium.

Marini Djang'Eing'A, R., Rozet, E., Ziemons, E., Chiap, P., Boulanger, B., Rudaz, S., Servais, A.-C., Fillet, M., Crommen, J., & Hubert, P. (May 2006). COMPARISON OF THREE DIFFERENT APPROACHES FOR UNCERTAINTY ESTIMATION CONSIDERING LC AND CE METHODS [Paper presentation]. A joint meeting of two distinguished series: the 8th International Symposium on Drug Analysis and the 17th International Symposium on Pharmaceutical and Biomedical Analysis, Namur, Belgium.

Lecomte, F., Boulanger, B., Hall, A. J., Sellergren, B., Crommen, J., Chiap, P., & Hubert, P. (March 2006). Développement d’une méthode de dosage automatisé du méthotrexate dans le plasma humain par couplage direct à la chromatographie liquide de l’extraction sur phase solide à empreintes moléculaires [Poster presentation]. Forum LABO & Forum BIOTECH 2006, Paris, France.

Servais, A.-C.* , Fillet, M.* , Mol, R., Somsen, G. W., Chiap, P., de Jong, G. J., & Crommen, J. (February 2006). On-line coupling of cyclodextrin mediated nonaqueous capillary electrophoresis to mass spectrometry for the determination of salbutamol enantiomers in urine. Journal of Pharmaceutical and Biomedical Analysis, 40 (3), 752-757. doi:10.1016/j.jpba.2005.08.004
* These authors have contributed equally to this work.

Crommen, J., Servais, A.-C., Fradi, I., Chiap, P., & Fillet, M. (2006). Enantiomeric separation of acidic compounds in nonaqueous capillary electrophoresis using single-isomer amino cyclodextrin derivatives as chiral selectors [Paper presentation]. 20th International Symposium on Microscale Bioseparations, Amsterdam, Netherlands.

Crommen, J., Servais, A.-C., Rousseau, A., Fradi, I., Chiap, P., & Fillet, M. (2006). Enantioseparations in nonaqueous capillary electrophoresis using charged cyclodextrin derivatives as chiral selectors [Paper presentation]. 30th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2006), San Francisco, United States.

Do Thi, T., Pomponi, R., Gotti, R., Saevels, J., Van Hove, B., Van Ael, W., Matthijs, N., Vander Heyden, Y., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., Fabre, H., Dehouck, P., Hoogmartens, J., & Van Schepdael, A. (2006). Precision study on capillary electrophoresis methods for metacycline. Electrophoresis, 27 (12), 2317-2329. doi:10.1002/elps.200500873

Fillet, M., Fradi, I., Pedrini, M., Chiap, P., Ivanyi, R., Crommen, J., & Servais, A.-C. (2006). Enantioseparation of nonsteroidal anti-inflammatory drugs using single-isomer amino cyclodextrin derivatives in nonaqueous capillary electrophoresis [Poster presentation]. 20th International Symposium on Microscale Bioseparations, Amsterdam, Netherlands.

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Rudaz, S., Rozet, E., Crommen, J., & Hubert, P. (2006). LC method for the determination of R-timolol in S-timolol maleate: Validation of its ability to quantify and uncertainty assessment. Talanta, 68 (4), 1166-1175. doi:10.1016/j.talanta.2005.07.026

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Rudaz, S., Rozet, E., Crommen, J., & Hubert, P. (2006). Comparaison de trois approches pour l'estimation de l'incertitude. Acta Clinica Belgica. Supplementum, (1), 60-2.

Marini Djang'Eing'A, R.* , Servais, A.-C.* , Rozet, E., Chiap, P., Boulanger, B., Rudaz, S., Crommen, J., Hubert, P., & Fillet, M. (2006). Nonaqueous capillary electrophoresis method for the enantiomeric purity determination of S-timolol using heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin: validation using the accuracy profile strategy and estimation of uncertainty. Journal of Chromatography. A, 1120 (1-2), 102-11. doi:10.1016/j.chroma.2006.03.104
* These authors have contributed equally to this work.

Martin, G., Chiap, P., Paquet, P., Pierard, G., Hubert, P., Crommen, J., & Fillet, M. (2006). Determination of catecholamines in human plasma using solid phase extraction and LC-ESI-MS-MS [Poster presentation]. Drug Analysis, Namur, Belgium.

Martin, G., Chiap, P., Paquet, P., Pierard, G., Rozet, E., Hubert, P., Crommen, J., & Fillet, M. (2006). Determination of a melanoma biomarker in human plasma the 5-S-cysteinyl-l-dopa by LC-ESI-MS-MS [Paper presentation]. 30rd international symposium on high performance liquid phase separation and related techniques, San Francisco, United States.

Martin, G., Chiap, P., Pierard, G., Hubert, P., Crommen, J., & Fillet, M. (2006). LC-ESI-MS-MS determination of 5-S-L-cysteinyl-L-dopa, a melanoma biomarker, in human plasma [Poster presentation]. Drug Analysis, Namur, Belgium.

Rozet, E., Boulanger, B., Dewe, W., Chiap, P., Moonen, F., Govaerts, B., Crommen, J., & Hubert, P. (2006). GERER LE RISQUE LORS DE LA VALIDATION DES METHODES ANALYTIQUES : APPLICATION A LA DETERMINATION D’IMPURETES [Paper presentation]. Congrès des Sciences Analytiques, Marrakech, Morocco.

Rozet, E., Dewé, W., Chiap, P., Lecomte, F., & Hubert, P. (2006). Le transfert d'une methode de dosage automatisee de la noradrenaline dans l'urine humaine: utilisation de l'erreur totale comme critere de decision. Acta Clinica Belgica. Supplementum, (1), 57-9.

Rozet, E., Dewe, W., Govaerts, B., Boulanger, B., Ceccato, A., Chiap, P., & Crommen, J. (2006). TOWARDS A RISK BASED METHODOLOGY TO ASSESS THE ACCEPTABILITY OF AN ANALYTICAL METHOD TRANSFER: COMPARISON OF DIFFERENT APPROACHES [Poster presentation]. Drug Analysis.

Rozet, E., Dewe, W., Morello, R., Chiap, P., Boos, K. S., & Hubert, P. (2006). Transfert d’une méthode de dosage automatisée de 3 catécholamines majeures dans l’urine humaine [Poster presentation]. Forum Labo.

Rozet, E., Morello, R., Dewe, W., Chiap, P., Boulanger, B., Boos, K. S., Crommen, J., & Hubert, P. (2006). TRANSFER OF A MULTIDIMENSIONAL ON-LINE SPE-LC-ECD METHOD FOR THE DETERMINATION OF THREE MAJOR CATECHOLAMINES IN NATIVE HUMAN URINE [Poster presentation]. HPLC.

Servais, A.-C., Fillet, M., Mol, R., Somsen, G., Chiap, P., de Jong, G. J., & Crommen, J. (2006). Determination of salbutamol enantiomers in urine by nonaqueous capillary electrophoresis-mass spectrometry [Poster presentation]. Drug Analysis 2006, Namur, Belgium.

Lecomte, F., Boulanger, B., Hall, A. J., Sellergren, B., Rozet, E., Crommen, J., Chiap, P., & Hubert, P. (September 2005). OPTIMIZATION OF MOLECULARLY IMPRINTED SOLID-PHASE EXTRACTION BY MEANS OF EXPERIMENTAL DESIGN PRIOR TO THE DETERMINATION OF METHOTREXATE IN HUMAN PLASMA [Poster presentation]. RDPA 2005 - 11th International Meeting on Recent Developments in Pharmaceutical Analysis, Rimini, Italy.

Crommen, J., Marini Djang'Eing'A, R., Servais, A.-C., Chiap, P., Rozet, E., Hubert, P., & Fillet, M. (June 2005). Validation of a NACE method for the enantiomeric purity determination of S-timolol using heptakis(2,3-di-O-methyl-6-O-sulfo)-B-CD [Paper presentation]. 29th International Symposium on High Perfomance Liquid Phase Separations and Related Techniques, Stockholm, Sweden.

Lecomte, F., Hall, A. J., Sellegren, B., Crommen, J., Hubert, P., & Chiap, P. (June 2005). Evaluation of molecularly imprinted polymers for selective extraction of methotrexate from human plasma prior to its LC determination [Poster presentation].   HPLC 2005 - 29th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Stockholm, Sweden.

Piette, M., Evrard, B., Frankenne, F., Chiap, P., Bertholet, P., Castagne, D., Foidart, J.-M., Delattre, L., & Piel, G. (June 2005). Pharmacokinetic study of a new syntheyic MMP inhibitor (Ro 28-2653) after IV and oral administration of solutions containing hydroxypropyl-b-cyclodextrin [Poster presentation]. 1st Pharmaceutical Sciences Fair and Exhibition (PharmSciFair), Nice, France.

Servais, A.-C., Fillet, M., Chiap, P., Dewé, W., Hubert, P., & Crommen, J. (11 March 2005). Influence of the nature of the electrolyte on the chiral separation of basic compounds in nonaqueous capillary electrophoresis using heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin. Journal of Chromatography. A, 1068 (1), 143-150. doi:10.1016/j.chroma.2004.12.010

Chiap, P., Piette, M., Evrard, B., Frankenne, F., Christiaens, B., Piel, G., Cataldo, D., Foidart, J.-M., Delattre, L., Crommen, J., & Hubert, P. (05 March 2005). Automated method for the determination of a new matrix metalloproteinase inhibitor in ovine plasma and serum by coupling of restricted access material for on-line sample clean-up to liquid chromatography. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 817 (1), 109-117. doi:10.1016/j.jchromb.2004.08.042

Piette, M., Evrard, B., Frankenne, F., Chiap, P., Bertholet, P., Castagne, D., Foidart, J.-M., Delattre, L., & Piel, G. (March 2005). Etude pharmacocinétique d'un nouvel inhibiteur des MMPs (I-col 51) après administration orale et intraveineuse de soultions à base d'hydroxypropyl-b-cyclodextrine [Paper presentation]. 8èmes Journées du Club français des Cyclodextrines, Nancy, France.

Marini Djang'Eing'A, R., Boulanger, B., Vanderheyden, Y., Chiap, P., Crommen, J., & Hubert, P. (21 February 2005). Uncertainty assessment from robustness testing applied on an LC assay for R-timolol and other related substances in S-timolol maleate. Analytica Chimica Acta, 531 (1), 131-140. doi:10.1016/j.aca.2004.10.004

Rbeida, O., Chiap, P., Lubda, D., Boos, K. S., Crommen, J., & Hubert, P. (04 January 2005). Development and validation of a fully automated LC method for the determination of cloxacillin in human plasma using anion exchancre restricted access material for sample clean-up. Journal of Pharmaceutical and Biomedical Analysis, 36 (5), 961-968. doi:10.1016/j.jpba.2004.09.017

Rbeida, O., Christiaens, B., Hubert, P., Lubda, D., Boos, K. S., Crommen, J., & Chiap, P. (04 January 2005). Integrated on-line sample clean-up using cation exchange restricted access sorbent for the LC determination of atropine in human plasma coupled to UV detection. Journal of Pharmaceutical and Biomedical Analysis, 36 (5), 947-954. doi:10.1016/j.jpba.2004.08.007

Chiap, P., Boulanger, B., Dewé, W., Crommen, J., & Hubert, P. (2005). Recent trends in the validation of bioanalytical methods [Paper presentation]. PharmSciFair, Nice, France.

Chiap, P., Rbeida, O., Boos, K. S., Hubert, P., & Crommen, J. (2005). Recent developments in on-line coupling of SPE to LC using restricted access materials with different functionalities [Paper presentation]. International seminar on solid-phase extraction in clinical and biopharmaceutical samples, Maastricht, Netherlands.

Chiap, P., Rbeida, O., Lubda, D., Boos, K. S., Crommen, J., & Hubert, P. (2005). Development and validation of a LC method for the determination of cloxacillin in plasma using anion exchange restricted access material for on-line sample clean-up [Poster presentation]. 29th international symposium on high performance liquid phase separations and related techniques, Stockholm, Sweden.

Crommen, J., Servais, A.-C., Fradi, I., Chiap, P., & Fillet, M. (2005). Enantioselective determination of pharmaceutical compounds in biofluids by coupling SPE to non-aqueous CE with charged cyclodextrins as chiral additives [Paper presentation]. 4th International Symposium on Separations in the BioSciences (SBS’05), Utrecht, Netherlands.

Crommen, J., Servais, A.-C., Fradi, I., Fillet, M., & Chiap, P. (2005). Enantioseparation of ionizable compounds in non-aqueous capillary electrophoresis using charged cyclodextrin derivatives as chiral additives [Paper presentation]. 29th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2005), Stockholm, Sweden.

Crommen, J., Servais, A.-C., Fradi, I., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., & Fillet, M. (2005). Enantiomeric separation of acidic and basic chiral drugs in non-aqueous capillary electrophoresis using cyclodextrin with the opposite charge [Paper presentation]. 11th meeting on recent developments in pharmaceutical analysis (RDPA), Rimini, Italy.

François, Y., Juillerat, E., Villemin, D., Chiap, P., Servais, A.-C., Varenne, A., & Gareil, P. (2005). Evaluation de liquides ioniques chiraux comme sélecteurs pour des séparations électrocinétiques d'énantiomères en veine liquide capillaire [Poster presentation]. 1er Symposium de Chimie et Biologie Analytiques (SCBA 2005) : De la molécule au protéome, Montpellier, France.

Ghuysen, A., Dogné, J.-M., Chiap, P., Rolin, S., Masereel, B., Lambermont, B., Kolh, P., Tchana-Sato, V., Hanson, J., & D'Orio, V. (2005). Pharmacological profile and therapeutic potential of BM-573, a combined thromboxane receptor antagonist and synthase inhibitor. Cardiovascular Drug Reviews, 23 (1), 1-14. doi:10.1111/j.1527-3466.2005.tb00153.x

Marini Djang'Eing'A, R., Matthijs, N., Vanderheyden, Y., Smeyers-Verbeke, J., Dehouck, P., Hoogmartens, J., Silvestre, P., Ceccato, A., Goedert, P., Saevels, J., Herbots, C., Caliaro, G., Herraez-Hernandez, R., Verdu-Andres, J., Campins-falco, P., de Wauw, W. V., De Beer, J., Boulanger, B., Chiap, P., ... Hubert, P. (2005). Collaborative study of an liquid chromatographic method for the determination of R-timolol and other related substances in S-timolol maleate. Analytica Chimica Acta, 546 (2), 182-192. doi:10.1016/j.aca.2005.05.026

Martin, G., Chiap, P., Paquet, P., Pierard, G., Hubert, P., & Crommen, J. (2005). Determination of catecholamines in human plasma using solid phase extraction and LC-ESI-MS-MS [Poster presentation]. 29th international symposium on high performance liquid phase separations and related techniques, Stockholm, Sweden.

Rozet, E., Chiap, P., Dewe, W., Boulanger, B., Crommen, J., & Hubert, P. (2005). The Usefulness of Accuracy Profile to Validate Analytical Methods [Paper presentation]. RDPA - Recent Developement in Pharmaceutical Analysis.

Rozet, E., Dewe, W., Chiap, P., Lecomte, F., & Hubert, P. (2005). Le transfert d’une méthode de dosage de 3 catécholamines majeures dans l’urine humaine: utilisation de l’erreur totale comme critère de décision [Paper presentation]. 3èmes Journées Internationales de Toxicologie Hospitalière.

Rozet, E., Dewé, W., Chiap, P., Lecomte, F., & Hubert, P. (2005). Le transfert d’une méthode de dosage automatisée de 3 catécholamines majeures dans l’urine humaine: utilisation de l’erreur totale comme critère de décision [Paper presentation]. 3èmes Journées Internationales de Toxicologie Hospitalière, Liege, Belgium.

Rozet, E., Mertens, B., Dewe, W., Govaerts, B., Boulanger, B., Chiap, P., Streel, B., Crommen, J., & Hubert, P. (2005). USING TOTAL ERROR AS DECISION CRITERION IN METHOD TRANSFER [Poster presentation]. RDPA-Recent Development on Pharmaceutical Analysis.

Dewé, W., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., & Boulanger, B. (28 December 2004). Development of response models for optimising HPLC methods. Chemometrics and Intelligent Laboratory Systems, 74 (2), 263-268. doi:10.1016/j.chemolab.2004.04.016

Hubert, P., Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Chiap, P., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Lallier, M., Laurentie, M., Mercier, N., Muzard, G., Nivet, C., & Valat, L. (15 November 2004). Harmonization of strategies for the validation of quantitative analytical procedures - A SFSTP proposal - part I. Journal of Pharmaceutical and Biomedical Analysis, 36 (3), 579-586. doi:10.1016/j.jpba.2004.07.027

Christiaens, B., Fillet, M., Chiap, P., Rbeida, O., Ceccato, A., Streel, B., De Graeve, J., Crommen, J., & Hubert, P. (12 November 2004). Fully automated method for the liquid chromatographic-tandem mass spectrometric determination of cyproterone acetate in human plasma using restricted access material for on-line sample clean-up. Journal of Chromatography. A, 1056 (1-2), 105-110. doi:10.1016/j.chroma.2004.06.107

Henry de Hassonville, S., Chiap, P., Liégeois, J.-F., Evrard, B., Delattre, L., Crommen, J., Piel, G., & Hubert, P. (21 September 2004). Development and validation of a high-performance liquid chromatographic method for the determination of cyproterone acetate in human skin. Journal of Pharmaceutical and Biomedical Analysis, 36 (1), 133-143. doi:10.1016/j.jpba.2004.05.023

Servais, A.-C., Fillet, M., Chiap, P., Dewé, W., Hubert, P., & Crommen, J. (August 2004). Enantiomeric separation of basic compounds usin heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin in combination with potassium camphorsulfonate in nonaqueous capillary electrophoresis: Optimization by means of an experimental design. Electrophoresis, 25 (16), 2701-2710. doi:10.1002/elps.200405962

Stevigny, C., Wautier, M. C., Jiwan, J. L. H., Chiap, P., Hubert, P., & Quetin-Leclercq, J. (August 2004). Development and validation of a high performance liquid chromatographic method for quantitative determination of aporphine alkaloids from different samples of Cassytha filiformis. Planta Medica, 70 (8), 764-770. doi:10.1055/s-2004-827209

Servais, A.-C., Chiap, P., Hubert, P., Crommen, J., & Fillet, M. (June 2004). Determination of salbutamol enantiomers in human urine using heptakis(2,3-di-O-acetyl-6-O-sulfo)-beta-cyclodextrin in nonaqueous capillary electrophoresis. Electrophoresis, 25 (10-11), 1632-1640. doi:10.1002/elps.200405854

Henry de Hassonville, S., Christiaens, B., Piel, G., Barillaro, V., Bertholet, P., Chiap, P., Hubert, P., Crommen, J., Delattre, L., Pierard, G., & Evrard, B. (May 2004). Effect of methylated-b-cyclodextrin on the skin and influence on cyproterone acetate percutaneous absorption [Poster presentation]. XII th International Cyclodextrin Symposium, Montpellier, France.

Rbeida, O., Christiaens, B., Hubert, P., Lubda, D., Boos, K. S., Crommen, J., & Chiap, P. (19 March 2004). Evaluation of a novel anion-exchange restricted-access sorbent for on-line sample clean-up prior to the determination of acidic compounds in plasma by liquid chromatography. Journal of Chromatography. A, 1030 (1-2), 95-102. doi:10.1016/j.chroma.2003.11.031

Marini Djang'Eing'A, R., Boulanger, B., Abushoffa, A., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (February 2004). ENANTIOMERIC PURITY TESTING OF S-KETOPROFEN IN PHARMACEUTICAL FORMULATIONS BY CE USING A DUAL CYCLODEXTRIN SYSTEM [Poster presentation]. 17th International Symposium on Microscale Separations and Capillary Electrophoresis, Salzburg, Austria.

Bimazubute, M., Chiap, P., Janssen, L., Gustin, P., Crommen, J., & Hubert, P. (2004). Automated determination of oxytetracycline in plasma of healthy pigs by at-line coupling of solid phase extraction to liquid chromatography [Poster presentation]. 15th international symposium on pharmaceutical and biomedical analysis, Florence, Italy.

Chiap, P., Dewé, W., Boulanger, B., Crommen, J., & Hubert, P. (2004). Use of accuracy profiles as efficient decision tool for the validation of quantitative analytical methods [Poster presentation]. 15th international symposium on pharmaceutical and biomedical analysis, Florence, Italy.

Chiap, P., Rbeida, O., Christiaens, B., Hubert, P., Lubda, D., Boos, K. S., & Crommen, J. (2004). Evaluation of novel restricted access sorbents with ion exchange properties for on-line sample clean-up prior to the LC determination of acidic of basic compounds in plasma [Poster presentation]. 15th international symposium on pharmaceutical and biomedical analysis, Florence, Italy.

Christiaens, G., Chiap, P., Fillet, M., Rbeida, O., Ceccato, A., Streel, B., De Graeve, J., Crommen, J., & Hubert, P. (2004). New fully automated method for the LC-MS/MS determination of cyproterone acetate in human plasma using restricted access material for sample clean-up [Poster presentation]. 8th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers (HTC-8), Bruges, Belgium.

Christians, B., Fillet, M., Chiap, P., Rbeida, O., Ceccato, A., Streel, B., De Graeve, J., Crommen, J., & Hubert, P. (2004). Fully automated method for the liquid chromatographic-tandem mass spectrometric determination of cyproterone acetate in human plasma using restricted access material for on-line sample clean-up. Journal of Chromatography. A, 1056 (1-2), 105-10.

Crommen, J., Rbeida, O., Chiap, P., Christiaens, B., Lubda, D., & Hubert, P. (2004). Evaluation de nouvelles phases à accès restreint échangeuses d’ions pour l’extraction sélective de comosoés médicamenteux dans le plasma avant leur analyse chromatographique [Poster presentation]. Forum labo et forum biotech, Paris, France.

Crommen, J., Servais, A.-C., Fillet, M., Chiap, P., Dewé, W., & Hubert, P. (2004). Enantiomeric separation of ionisable compounds in non-aqueous capillary electrophoresis using charged cyclodextrins in combination with ion-pairing reagents [Paper presentation]. 25th International Symposium on Chromatography (ISC 04), Paris, France.

Crommen, J., Servais, A.-C., Fillet, M., Chiap, P., Dewé, W., & Hubert, P. (2004). Enantiomeric separation of basic drugs using anionic cyclodextrins in non-aqueous capillary electrophoresis : optimization of the background electrolyte composition [Paper presentation]. 17th International Symposium on Microscale Separations an Capillary Electro-phoresis, Salzburg, Austria.

Crommen, J., Servais, A.-C., Fillet, M., Chiap, P., & Hubert, P. (2004). Enantiomeric separation in non-aqueous capillary electrophoresis using charged cyclodextrins in combination with other ionic additives [Paper presentation]. 15th International Symposium on pharmaceutical and biomedical analysis (PBA), Florence, Italy.

Henry de Hassonville, S., Christiaens, B., Piel, G., Barillaro, V., Bertholet, P., Chiap, P., Hubert, P., Crommen, J., Delattre, L., Pierard, G., & Evrard, B. (2004). La Rameb, un promoteur d’absorption cutanée pour l’acétate de cypro-térone ? [Paper presentation]. 7e journées du club cyclodextrines, Lille, France.

Herchuelz, A., Carreer-Bruhwyler, F., Crommen, J., Chiap, P., Hubert, P., Messin, R., Dubois, C., Famaey, J.-P., & Géczy, J. (2004). Clinical pharmacokinetics of once-daily molsidomine - From immediate-release to prolonged-release once-daily formulations. American Journal of Drug Delivery, 2 (2), 131-141. doi:10.2165/00137696-200402020-00005

Hubert, P., Boulanger, B., Dewé, W., Chiap, P., & Crommen, J. (2004). Harmonisation des stratégies de validation, utopie ou réalité ? [Paper presentation]. Forum labo et forum biotech, Paris, France.

Hubert, P., Chiap, P., Dormal, C., Crommen, J., Dewé, W., & Boulanger, B. (2004). Intérêt du profil d'exactitude dans le cadre de la validation des méthodes analytiques [Poster presentation]. Forum labo et Forum biotech, Paris, France.

Jaspart, S., Bodson, C., Bertholet, P., Chiap, P., Delattre, L., & Evrard, B. (2004). Solid lipid Nanoparticles for administration by inhalation : Optimisation of manufacturing parameters [Paper presentation]. European Conference on Drug Delivery and Pharmaceutical Technology, Sevilla, Spain.

Jaspart, S., Kirschvink, N., Chiap, P., Delattre, L., Crommen, J., Gustin, P., & Evrard, B. (2004). Solid lipid Nanoparticles for administration by inhalation : Optimisation of manufacturing parameters and preliminary tolerance study [Paper presentation]. 12eme Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Servais, A.-C., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (2004). Validation d’une méthode de dosage des énantiomères du salbutamol dans l’urine par électrophorèse capillaire en milieu non aqueux en utilisant une cyclodextrine anionique comme sélecteur chiral [Poster presentation]. Forum labo et forum biotech, Paris, France.

Servais, A.-C., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (2004). First application of non-aqueous capillary electrophoresis for the determination of the enantiomers of a basic chiral drug in biological samples: Quantification of salbutamol in human urine [Poster presentation]. 15th International Symposium on pharmaceutical and biomedical analysis (PBA), Florence, Italy.

Servais, A.-C., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (2004). Determination of salbutamol enantiomers in human urine using anionic cyclo-dextrins in non-aqueous capillary electrophoresis [Poster presentation]. 17th International Symposium on Microscale Separations an Capillary Electro-phoresis, Salzburg, Austria.

Stevigny, C., Wautier, M. C., Chiap, P., Hubert, P., & Quetin-Leclercq, J. (2004). Quantification of aporphines in cassytha filiformis bu HPLC/UV : validation and application [Poster presentation]. IUPAC Satellite Symposium Bioresources Towards Drug Discovery and Development, Mauritius.

Stevigny, C., Wautier, M. C., Habib Jiwan, J.-L., Chiap, P., Hubert, P., & Quetin-Leclercq, J. (2004). Development and validation of a high-performance liquid chromatographic method for quantitative determination of aporphine alkaloids from different samples of Cassytha filiformis L [Paper presentation]. Future trends in phytochemistry, Gargnano, Italy.

Christiaens, B., Chiap, P., Rbeida, O., Cello, D., Crommen, J., & Hubert, P. (25 September 2003). Fully automated method for the liquid chromatographic determination of cyproterone acetate in plasma using restricted access material for sample pre-treatment. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 795 (1), 73-82. doi:10.1016/S1570-0232(03)00517-8

Boulanger, B., Chiap, P., Dewé, W., Crommen, J., & Hubert, P. (08 August 2003). An analysis of the SFSTP guide on validation of chromatographic bioanalytical methods: progresses and limitations. Journal of Pharmaceutical and Biomedical Analysis, 32 (4-5), 753-765. doi:10.1016/S0731-7085(03)00182-1

Rbeida, O., Christiaens, B., Chiap, P., Hubert, P., Lubda, D., Boos, K. S., & Crommen, J. (08 August 2003). Fully automated LC method for the determination of sotalol in human plasma using restricted access material with cation exchange properties for sample clean-up. Journal of Pharmaceutical and Biomedical Analysis, 32 (4-5), 829-838. doi:10.1016/S0731-7085(03)00186-9

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Dewé, W., Hubert, P., & Crommen, J. (July 2003). LC method for the simultaneous determination of R-timolol and other closely related impurities in S-timolol maleate: Optimization by use of an experimental design. Journal of Separation Science, 26 (9-10), 809-817. doi:10.1002/jssc.200301367

Marini Djang'Eing'A, R., Chiap, P., & Hubert, P. (2003). NORMS AND GUIDELINES FOR THE PRACTICAL ESTIMATION OF UNCERTAINTY IN ANALYTICAL MEASUREMENTS. (Final rapport). Liège, Belgium: ULg.

Messin, R., Fenyvesi, T., Carreer-Bruhwyler, F., Crommen, J., Chiap, P., Hubert, P., Dubois, C., Famaey, J. P., & Geczy, J. (July 2003). A pilot double-blind randomized placebo-controlled study of molsidomine 16 mg once-a-day in patients suffering from stable angina pectoris: correlation between efficacy and over time plasma concentrations. European Journal of Clinical Pharmacology, 59 (3), 227-232. doi:10.1007/s00228-003-0597-z

Dewé, W., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., & Boulanger, B. (June 2003). Development of response models for optimizing HPLC methods [Poster presentation]. 27th Symposium on High Performance Liquid Phase Separations and Related Techniques, Nice, France.

Dehouck, P., Vander Heyden, Y., Smeyers-Verbecke, J., Massart, D. L., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., Van de Wauw, De Beer, Cox, R., Reepmeyer, Voigt, B., Estevenon, O., Nicolas, A., Van Schepdael, A., Adams, E., Hoogmartens, J., & Mathieu, G. (May 2003). Determination of uncertainty in a liquid chromatographic method for erythromycin from Interlaboratory study results [Paper presentation]. 11th Forum of the Belgian Society of Pharmaceutical Sciences (SBSP 2003), Spa, Belgium.

Hubert, P., Nguyen-Huu, J. J., Boulanger, B., Chapuzet, E., Chiap, P., Cohen, N., Compagnon, P. A., Dewé, W., Feinberg, M., Lallier, M., Laurentie, M., Mercier, N., Muzard, G., Nivert, C., & Valat, L. (May 2003). Validation des procédures analytiques quantitatives, Harmonisation des démarches. STP Pharma Pratiques, 13 (3), 101-138.

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Hubert, P., & Crommen, J. (May 2003). ASSESSMENT OF UNCERTAINTY FROM ROBUSTNESS TESTING OF A LC METHOD FOR THE DETERMINATION OF R-TIMOLOL AND OTHER RELATED SUBSTANCES IN S-TIMOLOL MALEATE [Paper presentation]. 11th Forum of the Pharmaceutical Sciences, Spa, Belgium.

Boulanger, B., Dewé, W., Chiap, P., Crommen, J., & Hubert, P. (2003). Objectives of analytical methods and objectives of validation [Paper presentation]. Landolake conference, Wisconsin, United States.

Boulanger, B., Marini Djang'Eing'A, R., Chiap, P., Dewé, W., Crommen, J., & Hubert, P. (2003). Objectives of analytical methods and objectives of validation : how to reconciliate them ? [Paper presentation]. HPLC 2003, 27th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Nice, France.

Chiap, P., Crommen, J., Dormal, C., Dewé, W., Boulanger, B., & Hubert, P. (2003). Intérêt du profil d’exactitude dans le cadre de la validation d’une méthode de dosage par chromatographie liquide du miconazole, de l’éconazole et du sor-bate dans les préparations à usage dermatologie [Poster presentation]. 5E Congrès francophone sur les techniques séparatives et les couplages (SEP 2003), Lyon, France.

Crommen, J., Servais, A.-C., Dewé, W., Chiap, P., Fillet, M., & Hubert, P. (2003). Enantiomeric separation of basic pharmaceuticals in non-aqueous capillary electrophoresis using an anionic cyclodextrin in combination with an ion-pairing reagent [Paper presentation]. 3th International Symposium on Separations in Biosciences (SBS 2003), Moscow, Russia.

Crommen, J., Servais, A.-C., Fillet, M., Abushoffa, A., Chiap, P., & Hubert, P. (2003). Modulation of selectivity for the enantiomeric separation of basic compounds in non-aqueous CE using anionic cyclodextrins in combination with ion-pairing re-agents [Paper presentation]. 27th International Symposium on high performance liquid phase separations and related techniques, Nice, France.

Dehouck, P., Vander Heyden, Y., Smeyers-Verbeke, J., Massart, D. L., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., Van de Wauw, W., De Beer, J., Cox, R., Mathieu, G., Reepmeyer, J. C., Voigt, B., Estevenon, O., Nicolas, A., Van Schepdael, A., Adams, E., & Hoogmartens, J. (2003). Interlaboratory study of a liquid chromatography method for erythromycin: determination of uncertainty. Journal of Chromatography. A, 1010 (1), 63-74. doi:10.1016/S0021-9673(03)01023-9

Dewé, W., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., & Boulanger, B. (2003). Development of response models for optimising HPLC methods [Poster presentation]. HPLC ‘03, 27th International Symposium on High Performance Liquid Phase Separations an Related Techniques, Nice, France.

Henry de Hassonville, S., Christiaens, B., Piel, G., Barillaro, V., Bertholet, P., Chiap, P., Hubert, P., Crommen, J., Delattre, L., Pierard, G., & Evrard, B. (2003). Cyclodextrins as topical permeation enhancers : in vitro and in vivo testing [Poster presentation]. Symposium skin and formulation APGI, Paris, France.

Hubert, P., Chiap, P., Dewé, W., Boulanger, B., & Crommen, J. (2003). Harmonization of validation strategies for analytical methods [Paper presentation]. 4th international symposium on pharmaceutical chemistry, Istanbul, Turkey.

Hubert, P., Chiap, P., Laurentie, M., Dewé, W., Boulanger, B., & Crommen, J. (2003). Harmonisation des démarches de validation, est-elle possible ? [Paper presentation]. 5E Congrès francophone sur les techniques séparatives et les couplages (SEP 2003), Lyon, France.

Martin, Y., Reynders, V., Chiap, P., Dormal, C., Hubert, P., & Crommen, J. (2003). Intérêt du profil d’exactitude dans le cadre de la validation d’une méthode de dosage par chromatographie liquide du miconazole, de l’éconazole et du sor-bate dans les préparations à usage dermatologie [Poster presentation]. 5E Congrès francophone sur les techniques séparatives et les couplages (SEP 2003), Lyon, France.

Servais, A.-C., Dewé, W., Chiap, P., Fillet, M., Abushoffa, A., Hubert, P., & Crommen, J. (2003). Separation énatiomérique de substances médicamenteuses basiques par électrophorèse capillarie en milieu non aqueux : effet de l’utilisation simul-tanée d’une cyclodextrine anionique et d’un agent d’appariement d’ions [Paper presentation]. 5e Congrès francophone sur les techniques séparatives et les couplages (SEP 2003), Lyon, France.

Evrard, B., Chiap, P., De Tullio, P., Ghalmi, F., Piel, G., Van Hees, T., Crommen, J., Losson, B., & Delattre, L. (13 December 2002). Oral bioavailability in sheep of albendazole from a suspension and from a solution containing hydroxypropyl-beta-cyclodextrin. Journal of Controlled Release, 85 (1-3), 45-50. doi:10.1016/S0168-3659(02)00270-5

Dewé, W., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., & Boulanger, B. (December 2002). Développement de modèles de réponse pour l’optimisation de méthodes HPLC [Paper presentation]. Chimiométrie 2002, Paris, France.

Servais, A.-C., Fillet, M., Chiap, P., Abushoffa, A. M., Hubert, P., & Crommen, J. (December 2002). Optimization of the separation of beta-blockers by ion-pair capillary electrophoresis in non-aqueous media using univariate and multivariate approaches. Journal of Separation Science, 25 (15-17), 1087-1095. doi:10.1002/1615-9314(20021101)25:15/17<1087::AID-JSSC1087>3.0.CO;2-A

Chiap, P., Rbeida, O., Christiaens, B., Hubert, P., Lubda, D., Boos, K. S., & Crommen, J. (25 October 2002). Use of a novel cation-exchange restricted-access material for automated sample clean-up prior to the determination of basic drugs in plasma by liquid chromatography. Journal of Chromatography. A, 975 (1), 145-155. doi:10.1016/S0021-9673(02)01334-1

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Dewé, W., Hubert, P., & Crommen, J. (April 2002). DEVELOPMENT AND VALIDATION OF A SIMULTANEOUS LC METHOD FOR THE DETERMINATION OF S-TIMOLOL MALEATE, ITS ANTIPODE AND RELATED SUBSTANCES USING A CELLULOSE BASED CHIRAL STATIONARY PHASE [Poster presentation]. Drug Analysis 2002 Symposium, Bruges, Belgium.

Chiap, P., Hubert, P., & Crommen, J. (01 March 2002). Strategy for the development of automated methods involving dialysis and trace enrichment as on-line sample preparation for the determination of basic drugs in plasma by liquid chromatography. Journal of Chromatography. A, 948 (1-2), 151-161. doi:10.1016/S0021-9673(01)01318-8

Marini Djang'Eing'A, R., Pantella, A., Bimazubute, M., Chiap, P., Hubert, P., & Crommen, J. (March 2002). Optimisation and validation of a generic method for the LC assay of six corticosteroids and salicylic acid in dermopharmaceutical forms. Chromatographia, 55 (5-6), 263-269. doi:10.1007/BF02491657

Chiap, P., Ceccato, A., Gora, R., Hubert, P., Geczy, J., & Crommen, J. (15 January 2002). Automated determination of pirlindole enantiomers in plasma by on-line coupling of a pre-column packed with restricted access material to a chiral liquid chromatographic column. Journal of Pharmaceutical and Biomedical Analysis, 27 (3-4), 447-455. doi:10.1016/S0731-7085(01)00647-1

Boulanger, B., Dewé, W., Chiap, P., Crommen, J., & Hubert, P. (2002). Objectives and analytical methods and objectives of validation [Paper presentation]. Barnett Conference, Philadelphie, United States.

Boulanger, B., Dewé, W., Chiap, P., Crommen, J., & Hubert, P. (2002). Objectifs des méthodes analytiques et objectifs de la validation. Comment les réconcilier pour garantir la qualité des résultats ? [Paper presentation]. Chimiométrie, Paris, France.

Boulanger, B., Dewé, W., Chiap, P., & Hubert, P. (2002). Objectives of validation : the statistical rationale of the SFSTP [Paper presentation]. Bioval 2002, London, United Kingdom.

Chiap, P., Lambert, E., Dormal, C., Hubert, P., Dewé, W., & Boulanger, B. (2002). Use of the accuracy profile for the validation of a generic LC method for the determination of miconazole, econazole and sorbate in dermatological forms [Poster presentation]. 7th International Symposium on Drug Analysis, Bruges, Belgium.

Chiap, P., Rbeida, O., Christiaens, B., Hubert, P., Lubda, D., Boos, K. S., & Crommen, J. (2002). Evaluation of a new kind of cation exchange restricted access sorbent for on-line solid phase extraction of basic drugs from plasma prior to their determination by liquid chromatography [Poster presentation]. 7th International Symposium on Drug Analysis, Bruges, Belgium.

Christiaens, B., Cello, D., Chiap, P., Rbeida, O., Hubert, P., & Crommen, J. (2002). Fully automated method for the liquid chromatographic determination of cyproterone acetate in plasma using restricted access material for sample pre-treatment [Poster presentation]. 7th International Symposium on Drug Analysis, Bruges, Belgium.

Hubert, P., Chiap, P., Dormal, C., Boulanger, B., Dewé, W., & Crommen, J. (2002). Intérêt du profil d'exactitude dans le cadre de la validation des méthodes analytiques [Paper presentation]. Forum Labo, Paris, France.

Hubert, P., Chiap, P., Dormal, C., Crommen, J., Dewé, W., & Boulanger, B. (2002). Intérêt du profil d’exactitude dans le cadre de la validation des méthodes ana-lytiques [Paper presentation]. Club chimiométrie et assurance qualité, INRA, Paris, France.

Hubert, P., Chiap, P., Dormal, C., Dewé, W., Boulanger, B., & Crommen, J. (2002). Statistical analysis of the validation results: diagnostic or decision tools [Paper presentation]. 7th International Symposium on Drug Analysis, Bruges, Belgium.

Rbeida, O., Christiaens, B., Chiap, P., Hubert, P., Lubda, D., Boos, K. S., & Crommen, J. (2002). The use of a novel cation exchange restricted access material for automated sample clean-up prior to the determination of basic drugs in plasma by liquid chromatography [Poster presentation]. 7th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers (HTC 7), Bruges, Belgium.

Servais, A.-C., Fillet, M., Chiap, P., Abushoffa, A., Hubert, P., & Crommen, J. (2002). Multivariate optimization approach for the separation of beta-blockers by ion-pair capillary electrophoresis in non-aqueous media [Poster presentation]. 7th International Symposium on Drug Analysis, Bruges, Belgium.

Marini Djang'Eing'A, R., Chiap, P., Hubert, P., & Crommen, J. (June 2001). SIMULTANEOUS LC DETERMINATION OF R-TIMOLOL MALEATE AND OTHER CLOSELY RELATED IMPURITIES IN S-TIMOLOL MALEATE USING A CELLULOSE BASED CHIRAL STATIONARY PHASE [Poster presentation]. 25th International Symposium on High Performance Liquid Phase Separations andr Related Technique, Maastricht, Netherlands.

Marini Djang'Eing'A, R., Chiap, P., Hubert, P., & Crommen, J. (25 May 2001). Separation and simultaneous determination of S-timolol maleate, its optical antipode and related substances by liquid chromatography using a cellulose based chiral stationary phase [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Toussaint, B., Palmer, M., Chiap, P., Hubert, P., & Crommen, J. (April 2001). On-Line Coupling of Partial Filling-Capillary Zone Electrophoresis with Mass Spectrometry for the Separation of Clenbuterol Enantiomers. Electrophoresis, 22 (7), 1363-72. doi:10.1002/1522-2683(200105)22:7<1363::AID-ELPS1363>3.0.CO;2-Q

Chiap, P., Ceccato, A., Miralles Buraglia, B., Boulanger, B., Hubert, P., & Crommen, J. (March 2001). Development and Validation of an Automated Method for the Liquid Chromatographic Determination of Sotalol in Plasma Using Dialysis and Trace Enrichment on a Cation-Exchange Pre-Column as on-Line Sample Preparation. Journal of Pharmaceutical and Biomedical Analysis, 24 (5-6), 801-14. doi:10.1016/S0731-7085(00)00547-1

Boulanger, B., Dewé, W., Chiap, P., & Hubert, P. (2001). Objectives of validation : the statistical rationale of the SFSTP [Paper presentation]. ISPC, Istanbul, Turkey.

Chiap, P., Boulanger, B., Fotsing, L., Hubert, P., & Crommen, J. (2001). Liquid chromatographic analysis of local anesthetics in human plasma after sample preparation by on-line dialysis. Optimization by use of experimental design. Chromatographia, 53 (11-12), 678-686. doi:10.1007/BF02493020

Chiap, P., Hubert, P., & Crommen, J. (2001). Strategy for the development of automated methods using dialysis and trace enrichment as on-line sample preparation techniques for the LC determination of drugs in plasma [Poster presentation]. HPLC 2001, Maastricht, Netherlands.

Hubert, P., Boulanger, B., Chiap, P., Dewé, W., & Crommen, J. (2001). Développements récents dans le domaine de la validation de méthodes en analyse pharmaceutique et biomédicale [Paper presentation]. SEP 2001, Paris, France.

Hubert, P., Chiap, P., Dewé, W., Boulanger, B., & Crommen, J. (2001). The usefulness of accuracy profiles in LC method validation [Paper presentation]. HPLC 2001, Maastricht, Netherlands.

Rbeida, O., Christiaens, B., Chiap, P., Hubert, P., & Crommen, J. (2001). A novel cation exchange restricted access material for precolumns in the LC analysis of basic drugs in plasma using the column switching technique [Poster presentation]. HPLC 2001, Maastricht, Netherlands.

Marini Djang'Eing'A, R., Pantella, A., Chiap, P., Bimazubute, M. A., Hubert, P., & Crommen, J. (April 2000). Development and validation of an LC method for the determination of six corticosteroids, salicylic acid and parabens in different pharmaceutical formulations [Paper presentation]. IXth Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Chiap, P., Buraglia, B. M., Ceccato, A., Hubert, P., & Crommen, J. (10 February 2000). Automated Liquid Chromatographic Determination of Atenolol in Plasma Using Dialysis and Trace Enrichment on a Cation-Exchange Precolumn for Sample Handling. Journal of Chromatography. B, Biomedical Sciences and Applications, 739 (1), 205-17. doi:10.1016/S0378-4347(99)00518-6

Chiap, P., Evrard, B., Bimazubute, M. A., De Tullio, P., Hubert, P., Delattre, L., & Crommen, J. (10 February 2000). Determination of Albendazole and Its Main Metabolites in Ovine Plasma by Liquid Chromatography with Dialysis as an Integrated Sample Preparation Technique. Journal of Chromatography. A, 870 (1-2), 121-34. doi:10.1016/S0021-9673(99)00938-3

Boulanger, B., Dewé, W., Chiap, P., & Hubert, P. (2000). Objectives of pre-study validation and decision rules [Paper presentation]. AAPS Workshop on bioanalytical methods validation – A revisit with a decade of progress, Arlington, United States.

Chapuzet, E., Mercier, N., Bervoas-Martin, S., Boulanger, B., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (2000). New strategy for the validation of chromatographic bioanalytical methods. STP Pharma Pratiques, 10 (1), 21-38.

Chapuzet, E., Mercier, N., Bervoas-Martin, S., Boulanger, B., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (2000). Example of application of the new strategy proposed for the validation of chromatographic bioanalytical methods. STP Pharma Pratiques, 10 (2), 79-101.

Chiap, P., Hubert, P., Boulanger, B., & Crommen, J. (2000). Plans d’expérience en biolanalyse : optimisation d’une méthode de dialyse pour le traitement d’échantillons plasmatiques préalable à leur analyse chromatographique [Paper presentation]. Journées du GMP, Bordeaux, France.

Chiap, P., Hubert, P., & Crommen, J. (2000). Techniques de préparation basées sur l'utilisation de membranes pour le traitement des échantillons biologiques préalable à leur analyse chromatographique. STP Pharma Pratiques, 10 (6), 361-374.

Crommen, J., Chiap, P., Fleischer, C. T., Boos, K. S., & Hubert, P. (2000). New trends in automated sample preparation coupled to LC for the determination of drugs in biological fluids [Paper presentation]. IXth International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2000), Basel, Switzerland.

Crommen, J., Chiap, P., & Hubert, P. (2000). Recent developments in automted sample preparation coupled to liquid chromatography for bioanalytical applications [Paper presentation]. Vth International Lichrospher ADS User Meeting, Munich, Germany.

Fotsing, L., Boulanger, B., Chiap, P., Fillet, M., Hubert, P., & Crommen, J. (2000). Multivariate optimization approach for the separation of water-soluble vitamins and related compounds by capillary electrophoresis. Biomedical Chromatography: BMC, 14 (1), 10-1. doi:10.1002/(SICI)1099-0801(200002)14:1<10::AID-BMC947>3.0.CO;2-8

Fotsing, L., Fillet, M., Boulanger, B., Chiap, P., Hubert, P., & Crommen, J. (2000). Determination of water-soluble vitamins and related compounds by capillary electrophoresis using a multivariate approach for method development [Poster presentation]. XIIIth International Symposium on High Performance Capillary Electrophoresis, Saarbrucken, Germany.

Hubert, P., Boulanger, B., Chiap, P., Dewé, W., & Crommen, J. (2000). Analyse statistique des résultats de validation de méthodes d’analyse chromatographiques [Paper presentation]. Les Journées du GMP, Bordeaux, France.

Bimazubute, M. A., Chiap, P., Marini Djang'Eing'A, R., Hubert, P., & Crommen, J. (May 1999). Development and validation of a LC method for the determination of bacitracin in a pharmaceutical dosage form [Paper presentation]. 8th Forum of Pharmaceutical Sciences, Spa, Belgium.

Bimazubute, M., Chiap, P., Fotsing, L., Hubert, P., & Crommen, J. (1999). Method development and validation for the LC quantitative analysis of bacitracin in a pharmaceutical formulation [Poster presentation]. XXIIIrd International Symposium on High Performance Liquid Phase Separations and Related Techniques, Grenade, Spain.

Ceccato, A., Toussaint, B., Chiap, P., Hubert, P., & Crommen, J. (1999). Automated Sample Preparation Techniques for the Determination of Drug Enantiomers in Biological Fluids Using Liquid Chromatography with Chiral Stationary Phases. Enantiomer, 4 (3-4), 305-15.

Chiap, P., Evrard, B., Bimazubute, M., De Tullio, P., Hubert, P., Delattre, L., & Crommen, J. (1999). On-line combinaison of dialysis with liquid chromatography for the automated determination of albendazole and its main metabolites in ovine plasma [Paper presentation]. VIIIème Forum des Sciences Pharmaceutiques, Spa, Belgium.

Chiap, P., Hubert, P., Bimazubute, M., Evrard, B., Delattre, L., & Crommen, J. (1999). LC determination of albendazole and its main metabolites in ovine plasma using dialysis as integrated sample preparation technique [Poster presentation]. XXIIIrd International Symposium on High Performance Liquid Phase Separations and Related Techniques, Grenade, Spain.

Chiap, P., Hubert, P., Boulanger, B., & Crommen, J. (1999). Validation of an automated method for the liquid chromatographic determination of atenolol in plasma: application of a new validation protocol. Analytica Chimica Acta, 391 (2), 227-238. doi:10.1016/S0003-2670(99)00117-8

Chiap, P., Toussaint, B., Hubert, P., & Crommen, J. (1999). Automated LC determination of drugs and metabolites in plasma using dialysis and trace enrichment as on-line sample preparation techniques [Paper presentation]. 1st International Symposium on SBS, Separation in the Biosciences, Amsterdam, Netherlands.

Crommen, J., Chiap, P., Ceccato, A., & Hubert, P. (1999). Fully automated methods for the LC determination of drug enantiomers in plasma using precolumns with Restricted Access Material (RAM) for sample pretreatement [Paper presentation]. Internationales LiChrospher ADS Anwender Treffen, Munich, Germany.

Crommen, J., Chiap, P., Toussaint, B., Ceccato, A., & Hubert, P. (1999). Développement et validation de méthodes entièrement automatisées pour le dosage de médicaments et de leurs métabolites dans les fluides biologiques [Paper presentation]. SEP’99 Techniques séparatives et couplages, Lyon, France.

Crommen, J., Fotsing, L., Fillet, M., Chiap, P., & Hubert, P. (1999). Method development and validation for the CE analysis of multi-vitamin formulations [Paper presentation]. Xth International Symposium on Pharmaceutical and Biomedical Analysis, Washington, United States.

Evrard, B., De Tullio, P., Chiap, P., Van Hees, T., Piel, G., Crommen, J., Losson, B., & Delattre, L. (1999). The effect of hydroxypropyl-b-cyclodextrins on the pharamacokinetics of albendazole in sheep. In Proceedings of 26th International Symposium on Controlled Release of Bioactive Materials.

Fotsing, L., Boulanger, B., Chiap, P., Fillet, M., Hubert, P., & Crommen, J. (1999). Multivariate optimisation approach for the separation of water-soluble vitamins and related compounds by capillary electrophoresis [Poster presentation]. IIIrd Miniaturisation in Liquid Chromatography versus Capillary Electrophoresis Conference, Gand, Belgium.

Fotsing, L., Boulanger, B., Chiap, P., Fillet, M., Hubert, P., & Crommen, J. (1999). Determination of copper, iron and zinc in pharmaceutical formulations by capillary electrophoresis [Poster presentation]. 23rd International Symposium on high performance liquid phase separations and related techniques, Grenade, Spain.

Fotsing, L., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (1999). Study of adsorption effects in the analysis of pharmaceutical formulations by CE. Journal de Pharmacie de Belgique, 54.

Fotsing, L., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (1999). Studies on the variability of migration times observed in the analysis of pharmaceutical formulations by capillary electrophoresis [Paper presentation]. 8e Forum des Sciences Pharmaceutiques, Spa, Belgium.

Fotsing, L., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (1999). Elimination of adsorption effects in the analysis of water-soluble vitamins in pharmaceutical formulations by capillary electrophoresis. Journal of Chromatography. A, 853 (1-2), 391-401. doi:10.1016/S0021-9673(99)00524-5

Fotsing, L., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (1999). Elimination of adsorption effects in the analysis of pharmaceutical formulations by capillary electrophoresis [Poster presentation]. XIIth International Symposium on High Performance Capillary Electrophoresis, Palm Springs, United States.

Hubert, P., Ceccato, A., Chiap, P., Toussaint, B., & Crommen, J. (1999). Préparation des échantillons d'origine biologique préalable à leur analyse chromatographique. STP Pharma Pratiques, 9 (2), 160-180.

Hubert, P., Chiap, P., Crommen, J., Boulanger, B., Chapuzet, E., Mercier, N., Bervoas-Martin, S., Chevalier, P., Grandjean, D., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (1999). The SFSTP guide on the validation of chromatographic methods for drug bioanalysis: from the Washington Conference to the laboratory. Analytica Chimica Acta, 391 (2), 135-148. doi:10.1016/S0003-2670(99)00106-3

Vander Heyden, Y., Saevels, J., Roets, E., Hoogmartens, J., Decolin, D., Quaglia, M. G., Van den Bossche, W., Leemans, R., Smeets, O., Van de Vaart, F., Mason, B., Taylor, G. C., Underberg, W., Bult, A., Chiap, P., Crommen, J., De Beer, J., Hansen, S. H., & Massart, D. L. (1999). Interlaboratory studies on two high-performance liquid chromatographic assays for tylosin (tartrate). Journal of Chromatography. A, 830 (1), 3-28. doi:10.1016/S0021-9673(98)00840-1

Ceccato, A., Boulanger, B., Chiap, P., Hubert, P., & Crommen, J. (11 September 1998). Simultaneous Determination of Methylphenobarbital Enantiomers and Phenobarbital in Human Plasma by on-Line Coupling of an Achiral Precolumn to a Chiral Liquid Chromatographic Column. Journal of Chromatography. A, 819 (1-2), 143-53. doi:10.1016/S0021-9673(98)00547-0

Chapuzet, E., Mercier, N., Bervoas-Martin, S., Boulanger, B., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorge, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (1998). Méthodes chromatographiques de dosage dans les milieux biologiques : exemple d'application de la stratégie de validation - Rapport d'une commission SFSTP. STP Pharma Pratiques, 8 (2), 81-107.

Chiap, P., Boulanger, B., Bimazubute, M., Hubert, P., & Crommen, J. (1998). Validation of an automated method for the LC determination of atenolol in plasma : application of a new validation strategy. Journal de Pharmacie de Belgique, 53, 171.

Chiap, P., Boulanger, B., Ceccato, A., Hubert, P., & Crommen, J. (1998). On-line coupling of dialysis to liquid chromatography for the automated determination of some local anaesthetics in human plasma. Journal de Pharmacie de Belgique, 53, 172.

Chiap, P., Planck, I., Evrard, B., Hubert, P., Delattre, L., & Crommen, J. (1998). Automated determination of acyclovir in human plasma using solid phase extraction and liquid chromatography. Journal de Pharmacie de Belgique, 53, 172.

Crommen, J., Ceccato, A., Fillet, M., Chiap, P., Toussaint, B., & Hubert, P. (1998). Method development and validation for the individual quantitation of drug en-antiomers using liquid chromatography or capillary electrophoresis [Paper presentation]. 3rd course on chiral chemistry, Project Tempus S-JEP-09101-95 « New Curriculum in Chiral Chemistry ».

Crommen, J., Chiap, P., Toussaint, B., Ceccato, A., & Hubert, P. (1998). Sample preparation strategies for the fully automated determination of drugs and metabolites in biologicals fluids [Paper presentation]. XIV Convegno nazionale, divisione di chimica farmaceutica, Società Chimica Italiana, Salsomaggiore Terme -–Parma, Italy.

Evrard, B., Chiap, P., Piel, G., Van Hees, T., Ghalmi, F., Losson, B., & Delattre, L. (1998). Influence of cyclodextrins on the solubility and the pharmacokinetics of albendazole [Poster presentation]. IXth International Cyclodextrin Symposium, Santiago de Compostela, Spain.

Ceccato, A., Chiap, P., Hubert, P., & Crommen, J. (26 September 1997). Automated Determination of Tramadol Enantiomers in Human Plasma Using Solid-Phase Extraction in Combination with Chiral Liquid Chromatography. Journal of Chromatography. B, Biomedical Sciences and Applications, 698 (1-2), 161-70. doi:10.1016/S0378-4347(97)00267-3

Ceccato, A., Toussaint, B., Chiap, P., Hubert, P., & Crommen, J. (June 1997). Enantioselective Determination of Oxprenolol in Human Plasma Using Dialysis Coupled on-Line to Reversed-Phase Chiral Liquid Chromatography. Journal of Pharmaceutical and Biomedical Analysis, 15 (9-10), 1365-74. doi:10.1016/S0731-7085(96)01965-6

Bervoas-Martin, S., Boulanger, B., Chapuzet, E., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, C. (1997). Méthodes chromatographiques de dosage dans les milieux biologiques : Stratégie de validation [Paper presentation]. XXIXth International seminar of SFSTP, Validation: quality enhancer, economic necessity, Montpellier, France.

Boulanger, B., Ceccato, A., Chiap, P., & Hubert, P. (1997). Selecting Derringer’s desirability functions that guarantee Pareto optimality : an application to the optimization of a liquid chromatography separation [Poster presentation]. HPLC 97, Birmingham, United Kingdom.

Ceccato, A., Boulanger, B., Chiap, P., Hubert, P., & Crommen, J. (1997). LC determination of mephobarbital enantiomers and phenobarbital in plasma using a precolumn with restricted access sorbent for sample clean-up [Poster presentation]. HPLC’ 97, Birmingham, United Kingdom.

Ceccato, A., Chiap, P., Hubert, P., & Crommen, J. (1997). Coupled-column LC analysis of mephobarbital enantiomers in plasma using restricted access packing material in the precolumn [Paper presentation]. VIth Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Ceccato, A., Chiap, P., Hubert, P., & Crommen, J. (1997). Automated determination of tramadol enantiomers in plasma using solid-phase extraction and chiral liquid chromatography [Poster presentation]. VIIIth International Symposium on Pharmaceutical and Biomedical Analysis, Orlando, United States.

Chapuzet, E., Mercier, N., Bervoas-Martin, S., Boulanger, B., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorge, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (1997). Méthodes chromatographiques de dosage dans les milieux biologiques : stratégie de validation - Rapport d'une commission SFSTP. STP Pharma Pratiques, 7 (3), 169-194.

Chiap, P., Ceccato, A., Miralles, B., Boulanger, B., Hubert, P., & Crommen, J. (1997). On-line combination of dialysis with trace enrichment on a cation-exchange precolumn for the automated LC determination of sotalol in plasma [Poster presentation]. HPLC 97, Birmingham, United Kingdom.

Chiap, P., Hubert, P., Ceccato, A., & Crommen, J. (1997). Automated LC determination of molsidomine and two of its metabolites in plasma using solid phase extraction as sample pretreatment [Poster presentation]. HPLC’ 97, Birmingham, United Kingdom.

Chiap, P., Miralles, B., Ceccato, A., Hubert, P., & Crommen, J. (1997). Automated liquid chromatographic determination of atenolol in plasma using dialysis and trace enrichment on a cation exchange precolumn for sample pre-treatement [Poster presentation]. VIIth meeting on recent developments in pharmaceutical analysis.

Crommen, J., Ceccato, A., Toussaint, B., Chiap, P., & Hubert, P. (1997). Fully automated systems for the liquid chromatographic determination of drug enantiomers in biological fluids [Paper presentation]. VIIth meeting on recent developments in pharmaceutical analysis.

Duvivier, D. H., Chiap, P., Crommen, J., & Lekeux, P. (1997). Evaluation of some parameters influencing the drug delivery from a dry powder inhalation device using an in vitro model of the horse airways. Veterinary Research, 28 (6), 557-564.

Ceccato, A., Chiap, P., Hubert, P., Toussaint, B., & Crommen, J. (25 October 1996). Automated Determination of Verapamil and Norverapamil in Human Plasma with on-Line Coupling of Dialysis to High-Performance Liquid Chromatography and Fluorometric Detection. Journal of Chromatography. A, 750 (1-2), 351-60. doi:10.1016/0021-9673(96)00471-2

Bervoas-Martin, S., Boulanger, B., Chapuzet, E., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, C. (1996). Méthodes chromatographiques de dosage dans les milieux biologiques : Stratégie de validation [Paper presentation]. Symposium de la SFSTP, Paris, France.

Ceccato, A., Hubert, P., Chiap, P., Toussaint, B., & Crommen, J. (1996). On-line dialysis coupled to liquid chromatography for the automated determination of verapamil and its demethylated metabolite in plasma, chapitre "biomedical analysis with hyphenated chromatography". In Hyphenated techniques in chromatography and hyphenated chromatographic analysers. K.V.C.V.

Ceccato, A., Hubert, P., Chiap, P., Toussaint, B., & Crommen, J. (1996). On-line dialysis coupled to liquid chromatography for the automated determination of verapamil and its demethylated metabolite in plasma [Paper presentation]. 4th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyses, Bruges, Belgium.

Ceccato, A., Toussaint, B., Chiap, P., Hubert, P., & Crommen, J. (1996). LC determination of oxprenolol enantiomers in human plasma using dialysis as on-line sample preparation technique. Journal de Pharmacie de Belgique, 51, 106.

Ceccato, A., Toussaint, B., Miralles, B., Chiap, P., Hubert, P., & Crommen, J. (1996). On-line dialysis coupled to liquid chromatography for the automated determination of oxprenolol enantiomers in human plasma [Poster presentation]. VIIth International Symposium on Pharmaceutical and Biomedical Analysis, Osaka, Japan.

Crommen, J., Chiap, P., Ceccato, A., & Hubert, P. (1996). Analytical technologies and tolls for drug purity testing [Paper presentation]. IIIrd EUFEPS Conference, Nuremberg, Germany.

Hubert, P., Chiap, P., & Crommen, J. (1996). Strategy for bioanalytical method validation : approach of SFSTP commission [Paper presentation]. KVCV Chemometrics Symposium ‘96, Louvain, Belgium.

Hubert, P., Chiap, P., & Crommen, J. (1996). Method validation in a European context, Chromatografische informatie in cyberspace en in andere moderne media [Paper presentation]. KVCV Symposium, Bruxelles, Belgium.

Ceccato, A., Hubert, P., Toussaint, B., Chiap, P., & Crommen, J. (1995). Automated determination of verapamil and norverapamil in human plasma by high performance chromatography using dialysis as on-line sample preparation technique [Poster presentation]. XIXth International Symposium on Column Liquid Chromatography and Related Techniques, Innsbruck, Austria.

Chiap, P., Hubert, P., Ceccato, A., Fillet, M., & Crommen, J. (1995). Automated HPLC analysis of molsidomine and two of its metabolites in human plasma using solid phase extraction as sample preparation. Journal de Pharmacie de Belgique, 50, 320.

Chiap, P., Hubert, P., Ceccato, A., Toussaint, B., & Crommen, J. (1995). Comparison of solid-phase extraction and dialysis as on-line sample preparation procedures for the automated HPLC determination of verapamil and norverapamil in human plasma. Journal de Pharmacie de Belgique, 50, 321.

Evrard, B., Hubert, P., Chiap, P., Crommen, J., & Delattre, L. (1995). A fully automated HPLC method for pharmacokinetic studies on a long-acting sulfamethazine veterinary bolus. Journal de Pharmacie de Belgique, 50, 328.

Evrard, B., Hubert, P., Chiap, P., Crommen, J., & Delattre, L. (1995). A fully automated HPLC method for pharmacokinetic studies on a long-acting sulfamethazine veterinary bolus [Paper presentation]. 5th International Symposium on Drug Analysis, Leuven, Belgium.

Fillet, M., Bechet, I., Chiap, P., Hubert, P., & Crommen, J. (1995). Enantiomeric purity of propranolol by cyclodextrin modified capillary electrophoresis [Poster presentation]. VIth International Symposium on Chiral Discrimination, Saint Louis, United States.

Hubert, P., Chiap, P., Ceccato, A., Bechet, I., & Crommen, J. (1995). Automated determination of camazepam in human plasma by solid phase extraction coupled to HPLC. Journal de Pharmacie de Belgique, 50, 341.

Hubert, P., Chiap, P., Ceccato, A., & Crommen, J. (1995). Validation of bioanalytical methods. Journal de Pharmacie de Belgique, 50, 290.

Hubert, P., Chiap, P., Ceccato, A., & Crommen, J. (1995). Automated solid-phase extraction coupled to HPLC for the determination of drugs in biological fluids. Pharmacy World and Science, 17, 5.

Hubert, P., Chiap, P., Ceccato, A., Fillet, M., & Crommen, J. (1995). Automated determination of acetylsalicylic, salicylic and salicyluric acids in human plasma using solid-phase extraction and HPLC. Journal de Pharmacie de Belgique, 50, 341.

Hubert, P., Chiap, P., Ceccato, A., Streel, B., & Crommen, J. (1995). Determination of several benzodiazepines in plasma using automated solid-phase extraction coupled to high performance chromatography [Poster presentation]. XIXth International Symposium on Column Liquid Chromatography and Related Techniques, Innsbruck, Austria.

Streel, B., Ceccato, A., Chiap, P., Hubert, P., & Crommen, J. (1995). Injection-generated solvent and pH gradients for sample enrichment on injection of large volumes in microclumn liquid chromatography. Biomedical Chromatography: BMC, 9, 254-256.

Streel, B., Hubert, P., Ceccato, A., Chiap, P., & Crommen, J. (1995). Injection-generated solvent and pH gradients for sample enrichment on injection of large volumes in microcolumn liquid chromatography [Poster presentation]. Symposium «Miniaturisering in vloeistofchromatografie versus capillaire elektroforese», Gand, Belgium.

Streel, B., Hubert, P., Ceccato, A., Chiap, P., & Crommen, J. (1995). Determination of phenothiazines by microcolumn liquid chromatography using injection-generated gradient techniques for sample enrichment. Journal de Pharmacie de Belgique, 50, 398.

Toussaint, B., Ceccato, A., Chiap, P., Hubert, P., & Crommen, J. (1995). On-line combination of dialysis and liquid chromatography for the automated determination of oxprenolol in human plasma. Journal de Pharmacie de Belgique, 50, 403.

Hubert, P., Chiap, P., Moors, M., Bourguignon, B., Massart, D. L., & Crommen, J. (08 April 1994). Knowledge-Based System for the Automated Solid-Phase Extraction of Basic Drugs from Plasma Coupled with Their Liquid Chromatographic Determination. Application to the Biodetermination of Beta-Receptor Blocking Agents. Journal of Chromatography. A, 665 (1), 87-99. doi:10.1016/0021-9673(94)87035-7

Chiap, P., Hubert, P., & Crommen, J. (1994). HPLC determination of some -adrenergic blocking agents in plasma using automated solid-phase extraction and fluorometric detection [Poster presentation]. VIth International Symposium on Luminescence Spectrometry in Biomedical Analysis, Bruges, Belgium.

Chiap, P., Hubert, P., & Crommen, J. (1994). Development of an automated solid phase extraction method coupled to HPLC for the determination of some benzodiazepines in plasma by use of a knowledge-based system. Journal de Pharmacie de Belgique, 49, 61.

Fillet, M., Bechet, I., Chiap, P., Hubert, P., & Crommen, J. (1994). Enantiomeric purity determination of propranolol enantiomers by capillary electrophoresis [Poster presentation]. IXth International Symposium on Capillary Electrophoresis, Budapest, Hungary.

Moors, M., Bourguignon, B., Massart, D. L., Hubert, P., Chiap, P., & Crommen, J. (1994). A knowledge-based system for developping solid-phase extraction methods with the ASPEC system, chapitre #D-3. In E. Reid, H. M. Hill, ... I. D. Wilson, Biofluid and tissue analysis for drugs, including hypolipidaemics. Cambridge, United Kingdom: Royal Society of Chemistry.

Hubert, P., Chiap, P., Evrard, B., Delattre, L., & Crommen, J. (08 December 1993). Fully Automated Determination of Sulfamethazine in Ovine Plasma Using Solid-Phase Extraction on Disposable Cartridges and Liquid Chromatography. Journal of Chromatography. A, 622 (1), 53-60. doi:10.1016/0378-4347(93)80249-4

Hubert, P., Chiap, P., Ceccato, A., & Crommen, J. (1993). Fully automated systems for the bioanalysis of drugs and metabolites using solid-phase extraction in combination with liquid chromatography [Paper presentation]. 9th International Symposium on Advances and Applications of Chromatography in Industry, Bratislava, Slovakia.

Hubert, P., Chiap, P., Moors, M., Massart, D. L., & Crommen, J. (1993). Development of a knowledge-based system for the autaomated solid-phase extraction of basic drugs from plasma prior to HPLC determination. Journal de Pharmacie de Belgique, 48, 114.

Hubert, P., Chiap, P., Moors, M., Massart, D. L., & Crommen, J. (1993). A hypermedia knowledge-based system for the automated solid-phase extraction of basic drugs from plasma coupled to their HPLC determination [Paper presentation]. 17th International Symposium on Column Chromatography, Hamburg, Germany.

Massart, D. L., Hubert, P., Chiap, P., Moors, M., Crommen, J., & Bourguignon, B. (1993). Knowledge-based systems for method development in solid-phase extraction [Paper presentation]. 10th International Bioanalytical Forum, Guilford, United Kingdom.

Chiap, P., Hubert, P., Bechet, I., & Crommen, J. (1992). Automated HPLC analysis of diltiazem and desacetyldiltiazem in plasma using disposabele extraction cartridges. Journal de Pharmacie de Belgique, 47, 196.

Hubert, P., Chiap, P., Ceccato, A., Bechet, I., Sibenaler-Dechamps, R., Maes, P., & Crommen, J. (1992). Determination of verapamil and norverapamil in human plasma by liquid chromatography: comparison between a liquid-liquid extraction procedure and an automated liquid-solid extraction method for sample preparation. Journal of Pharmaceutical and Biomedical Analysis, 10 (10-12), 937-42. doi:10.1016/0731-7085(91)80102-F

Hubert, P., Chiap, P., Ceccato, A., & Crommen, J. (1992). HPLC determination of propranolol, verapamil and norverapamil in plasma using automated liquid-solid extraction and fluorometric detection. Journal de Pharmacie de Belgique, 47, 196.

Hubert, P., Chiap, P., Sibenaler-Dechamps, R., Maes, P., & Crommen, J. (1992). Comparison of liquid-liquid extraction and liquid-solid extraction methods for the HPLC determination of verapamil and norverapamil in human plasma. Journal de Pharmacie de Belgique, 47, 259.

Hubert, P., Chiap, P., & Crommen, J. (1991). Fully automated analysis of basic drugs in plasma using liquid-solid extraction on individual cartridges and HPLC [Paper presentation]. IIIrd International Symposium on Pharmaceutical and Biomedical Analysis, Boston, United States.

Hubert, P., Chiap, P., & Crommen, J. (1991). Automatic Determination of Diltiazem and Desacetyldiltiazem in Human Plasma Using Liquid-Solid Extraction on Disposable Cartridges Coupled to Hplc--Part II: Optimization of Liquid-Solid Extraction. Journal of Pharmaceutical and Biomedical Analysis, 9 (10-12), 883-887. doi:10.1016/0731-7085(91)80018-5

Hubert, P., Chiap, P., & Crommen, J. (1991). Automatic Determination of Diltiazem and Desacetyldiltiazem in Human Plasma Using Liquid-Solid Extraction on Disposable Cartridges Coupled to Hplc--Part I: Optimization of the Hplc System and Method Validation. Journal of Pharmaceutical and Biomedical Analysis, 9 (10-12), 877-882. doi:10.1016/0731-7085(91)80017-4

Hubert, P., Chiap, P., & Crommen, J. (1991). Automatic determination of diltiazem and desacetyldiltiazem in human plasma using liquid-solid extraction on disposable cartridges coupled to HPLC [Poster presentation]. Vth Symposium on Handling of Environmental and Biological Samples in Chromatography, Baden-Baden, Germany.