Zouaoui, E., Mercuri, P., Radaoui, A., Ben Salah, N., Galleni, M., Ben-Mahrez, K., & Réjiba, S. (2023). High Prevalence of blaNDM Among Carbapenem Non‑Susceptible Klebsiella pneumoniae in a Tunisian Hospital First Report of blaNDM‑9, blaKPC‑20, and blaKPC‑26 Genes. Current Microbiology, 80 (152). doi:10.1007/s00284-023-03268-2 |
Gavara, L., Verdirosa, F., Sevaille, L., Legru, A., Corsica, G., Nauton, L., Mercuri, P., Sannio, F., De Luca, F., Hadjadj, M., Cerboni, G., Vo Hoang, Y., Licznar-Fajardo, P., Galleni, M., Docquier, J.-D., & Hernandez, J.-F. (11 August 2022). 1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors. Bioorganic and Medicinal Chemistry, 72, 116964. doi:10.1016/j.bmc.2022.116964 |
Lupo, V., Mercuri, P., Frère, J.-M., Joris, B., Galleni, M., Baurain, D.* , & Kerff, F.*. (2022). An Extended Reservoir of Class-D Beta-Lactamases in Non-Clinical Bacterial Strains. Microbiology Spectrum, 10 (2), 0031522. doi:10.1128/spectrum.00315-22 * These authors have contributed equally to this work. |
de Barsy, M., Mercuri, P., Oueslati, S., Elisée, E., Huang, T.-D., Sacré, P., Iorga, B. I., Naas, T., Galleni, M., & Bogaerts, P. (18 October 2021). Detection and Characterization of VIM-52, a New Variant of VIM-1 from a Klebsiella pneumoniae Clinical Isolate. Antimicrobial Agents and Chemotherapy, 65 (Issue 11), 02660-20. doi:10.1128/AAC.02660-20 |
Piccirilli, A., Mercuri, P., Segatore, B., Galleni, M., Brisdelli, F., Kerff, F., Amicosante, G., & Perilli, M. (June 2021). Laboratory Variants GESG170L, GESG170K, and GESG170H Increase Carbapenem Hydrolysis and Confer Resistance to Clavulanic Acid. Antimicrobial Agents and Chemotherapy, 65 (6), 01931-20. doi:10.1128/AAC.01931-20 |
Toncheva-Moncheva, N., Aqil, A., Galleni, M., & Jérôme, C. (June 2021). Conversion of electrospun chitosan into chitin: a robust strategy to tune the properties of 2D biomimetic nanofiber scaffolds. Polysaccharides, 2 (2), 271-286. doi:10.3390/polysaccharides2020019 |
Piccirilli, A., Criscuolo, E., Brisdelli, F., Mercuri, P., Cherubini, S., De Scicio, M. L., Maccarrone, M., Galleni, M., Amicosante, G., & Perilli, M. (2021). Exploring the Role of L10 Loop in New Delhi Metallo- beta-lactamase (NDM-1): Kinetic and Dynamic Studies. Molecules, 26, 5489. doi:10.3390/molecules26185489 |
Mercuri, P., Esposito, R., Blétard, S., Di Costanzo, S., Perilli, M., Kerff, F., & Galleni, M. (2020). Mutational Effects on Carbapenem Hydrolysis of YEM-1, a New Subclass B2 Metallo-β-Lactamase from Yersinia mollaretii. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.00105-20 |
Ceasar, S. A., Lekeux, G., Motte, P., Xiao, Z., Galleni, M., & Hanikenne, M. (2020). di-Cysteine Residues of the Arabidopsis thaliana HMA4 C-Terminus Are Only Partially Required for Cadmium Transport. Frontiers in Plant Science, 11, 560. doi:10.3389/fpls.2020.00560 |
Mercuri, P., Esposito, R., Blétard, S., Di Costanzo, S., Perilli, M., Kerff, F., & Galleni, M. (22 June 2019). Mutational Effects in Carbapenem Hydrolysis of YEM-1, a New Sub-Class B2 Metallo-beta-Lactamase from Yersinia mollaretii [Poster presentation]. asm microbe, San Francisco Ca, United States. |
De Franco, S., Vandenameele, J., Brans, A., Verlaine, O., Bendak, K., Damblon, C., Matagne, A., Segal, D., Galleni, M., Mackay, J., & Vandevenne, M. (21 February 2019). Exploring the suitability of RanBP2-type Zinc Fingers for RNA-binding protein design. Scientific Reports, 9 (1), 2484. doi:10.1038/s41598-019-38655-y |
Lekeux, G.* , Crowet, J.-M.* , Nouet, C., Joris, M., Jadoul, A., Bosman, B., Carnol, M., Motte, P., Lins, L., Galleni, M., & Hanikenne, M. (2019). Homology modeling and in vivo functional characterization of the zinc permeation pathway in a heavy metal P-type ATPase. Journal of Experimental Botany, 70, 329-341. doi:10.1093/jxb/ery353 * These authors have contributed equally to this work. |
Guérin, V., Thiry, D., Galleni, M., Saulmont, M., & Mainil, J. (26 October 2018). β-lactamase-encoding gene identification by microarrays in phenotypically resistant Escherichia coli from young calves in Wallonia, Belgium [Paper presentation]. 5th FARAH DAY. |
Dondelinger, M., Filée, P., Sauvage, E., Quinting, B., Muyldermans, S., Galleni, M., & Vandevenne, M. (16 October 2018). Understanding the significance and implications of antibody numbering and antigen-binding surface/residue definition. Frontiers in Immunology, 9 (OCT). doi:10.3389/fimmu.2018.02278 |
Guérin, V., Thiry, D., Galleni, M., Saulmont, M., & Mainil, J. (August 2018). Beta-lactamase-encoding gene identification by micro-arrays in phenotypically resistant pathogenic Escherichia coli from young calves in Wallonia, Belgium [Paper presentation]. The 30th World Buiatric Congress 2018 Sapporo, Sapporo, Japan. |
Cawez, F., Duray, E., Hu, Y., Vandenameele, J., Romao, E., Vinckle, C., Dumoulin, M., Galleni, M., Muyldermans, S., & Vandevenne, M. (25 May 2018). Combinatorial Design of a Nanobody that Specifically Targets Structured RNAs. Journal of Molecular Biology, 430 (11), 1652-1670. doi:10.1016/j.jmb.2018.03.032 |
Vandevenne, M., Dondelinger, M., Yunus, S., Freichels, A., Freichels, R., Crasson, O., Rhazi, N., Bogaerts, P., Galleni, M., & Filée, P. (2018). The use of a β-lactamase – based conductimetric biosensor assay to detect biomolecular interactions. Journal of Visualized Experiments, (132). doi:10.3791/55414 |
Marcoccia, F., Mercuri, P., Galleni, M., Celenza, G., Amicosante, G., & Perilli, M. (2018). A Kinetic Study of the Replacement by Site Saturation Mutagenesis of Residue 119 in NDM-1 Metallo- beta-Lactamase. Antimicrobial Agents and Chemotherapy, 62 (8). doi:10.1128/AAC.02541-17 |
Rodríguez, M. M., Herman, R., Ghiglione, B., Kerff, F., D'Amico González, G., Bouillenne, F., Galleni, M., Handelsman, J., Charlier, P., Gutkind, G., Sauvage, E., & Power, P. (July 2017). Crystal Structure and Kinetic Analysis of the Class B3 Di-Zinc Metallo-β-Lactamase LRA-12 from an Alaskan Soil Metagenome. PLoS ONE, 12 (7), 0182043. doi:10.1371/journal.pone.0182043 |
Amisano, F., Silvestri, M., Mercuri, P., Gagliardi, A., Bini, L., Frère, J.-M., & Galleni, M. (17 June 2017). Study of the outer membrane permeability of Pseudomonas aeruginosa to ß-lactam antibiotics [Poster presentation]. 13th Beta lactamase meeting, Santo Stefano di Sessanio, Italy. |
Marcoccia, F., Melchiorre, C., Robert, C., Mercuri, P., Galleni, M., Celenza, G., Amicosante, G., & Perilli, M. (June 2017). NDM-1 could still evolve: analysis of a random mutagenesis in position 123 [Poster presentation]. 13th β-lactamase Meeting", Santo Stefano di Sessanio, l'Aquila, Italy. |
Mercuri, P., Blétard, S., Kerff, F., & Galleni, M. (June 2017). Characterisation of the sub-class B2 metallo-β-lactamase of Yersinia mollaretii Wauters [Poster presentation]. 13th β-lactamase Meeting", Santo Stefano di Sessanio, l'Aquila, Italy. |
Piccirilli, A., Perilli, M., Mercuri, P., Aschi, M., Segatore, B., Galleni, M., Celenza, G., & Amicosante, G. (June 2017). Replacement of proline 174 with glutamic acid in GES-1 enzyme improve the flexibility of Ω-loop leading to an increase of catalytic efficiency towards carbapenems [Poster presentation]. 13th β-lactamase Meeting", Santo Stefano di Sessanio, l'Aquila, Italy. |
Chevigne, A., Campizi, V., Szpakowska, M., Bourry, D., Dumez, M.-E., Martins, J. C., Matagne, A., Galleni, M., & Jacquet, A. (2017). The Lys-Asp-Tyr Triad within the Mite Allergen Der p 1 Propeptide Is a Critical Structural Element for the pH-Dependent Initiation of the Protease Maturation. International Journal of Molecular Sciences, 18 (5). doi:10.3390/ijms18051087 |
Crasson, O., Courtade, G., Léonard, R., Aachmann, F., Legrand, F., Parente, R., Baurain, D., Galleni, M., Sorlie, M., & Vandevenne, M. (2017). Human chitotriosidase: Catalytic domain or carbohydrate binding module, who's leading HCHT's biological function. Scientific Reports, 7 (1). doi:10.1038/s41598-017-02382-z |
Sevaille, L., Gavara, L., Bebrone, C., De Luca, F., Nauton, L., Achard, M., Mercuri, P., Tanfoni, S., Borgianni, L., Guyon, C., Lonjon, P., Turan-Zitouni, G., Dzieciolowski, J., Becker, K., Bénard, L., Condon, C., Maillard, L., Martinez, J., Frère, J.-M., ... Hernandez, J.-F. (2017). 1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases. ChemMedChem, 12, 972-985. doi:10.1002/cmdc.201700186 |
Fernea, A., Galleni, M., & Frère, J.-M. (2016). Kinetics of the Interaction between BAL29880 and LK157 and the Class C β-Lactamase CHE-1. Antimicrobial Agents and Chemotherapy, 60, 1747-1750. doi:10.1128/AAC.02062-15 |
Laurent, C.* , Lekeux, G.* , Ukuwela, A. A., Xiao, Z., Charlier, J.-B., Bosman, B., Carnol, M., Motte, P., Damblon, C., Galleni, M., & Hanikenne, M. (2016). Metal binding to the N-terminal cytoplasmic domain of the PIB ATPase HMA4 is required for metal transport in Arabidopsis. Plant Molecular Biology, 90, 453-466. doi:10.1007/s11103-016-0429-z * These authors have contributed equally to this work. |
Marcoccia, F., Bottoni, C., Sabatini, A., Colapietro, M., Mercuri, P., Galleni, M., Kerff, F., Matagne, A., Celenza, G., Amicosante, G., & Perilli, M. (2016). Kinetic Study of Laboratory Mutants of NDM-1 Metallo-beta-Lactamase and the Importance of an Isoleucine at Position 35. Antimicrobial Agents and Chemotherapy, 60 (4), 2366-72. doi:10.1128/AAC.00531-15 |
Herman, J., Thelen, N., Smargiasso, N., Mailleux, A.-C., Luxen, A., Cloes, M., De Pauw, E., Chevigné, A., Galleni, M., & Dumez, M.-E. (2014). Der p 1 is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus. Biochimica et Biophysica Acta - General Subjects, 1840 (3), 1117–1124. doi:10.1016/j.bbagen.2013.11.017 |
Power, P., Sauvage, E., Herman, R., Gutkin, G., Galleni, M., Charlier, P., & Kerff, F. (2014). The crystal structure of the carbapenemase OXA-24 in complex with tazobactam reveals evidences about the intereaction with beta-lactamase inhibitors and lysine carboxylation [Poster presentation]. 54th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, United States - District of Columbia. |
Ruggiero, M., Kerff, F., Herman, R., Sapunaric, F., Galleni, M., Gutkind, G., Charlier, P., Sauvage, E., & Power, P. (2014). Crystal Structure of the Extended-Spectrum β -Lactamase PER-2 and Insights into the Role of Specific Residues in the Interaction with β -Lactams and β -Lactamase Inhibitors. Antimicrobial Agents and Chemotherapy, 58 (10), 5994-6002. doi:10.1128/AAC.00089-14 |
Huynen, C., Filée, P., Matagne, A., Galleni, M., & Dumoulin, M. (28 August 2013). Class A β -Lactamases as Versatile Scaffolds to Create Hybrid Enzymes: Applications from Basic Research to Medicine. BioMed Research International, 2013, 16. doi:10.1155/2013/827621 |
Henrottin, J., Zervosen, A., Lemaire, C., Galleni, M., & Luxen, A. (May 2013). Automated radiosynthesis of 1-(2-[18F]fluoroethyl)-tryptophan, a potential substrate for indoleamine 2,3-dioxygenase PET imaging [Poster presentation]. The 20th International Symposium on Radiopharmaceutical Sciences - ISRS 2013, Jéju, South Korea. |
Sohier, J., Laurent, C., Chevigné, A., Pardon, E., Srinivasan, V., Wernery, U., Lassaux, P., Steyaert, J., & Galleni, M. (15 March 2013). Allosteric inhibition of VIM metallo-beta-lactamase by a camelid nanobody. Biochemical Journal, 450 (3), 477-486. doi:10.1042/BJ20121305 |
Berlemont, R., Spee, O., Delsaute, M., Lara, Y., Schuldes, J., Simon, C., Power, P., Daniel, R., & Galleni, M. (2013). Novel organic solvent-tolerant esterase isolated by metagenomics: insights into the lipase/esterase classification. Revista Argentina de Microbiologia, (45), 3-12. |
Dumez, M.-E., Herman, J., Campisi, V., Bouaziz, A., Rosu, F., Luxen, A., Vandenberghe, I., De Pauw, E., Frère, J.-M., Matagne, A., Chevigne, A., & Galleni, M. (2013). The proline-rich motif of the proDer p 3 allergen propeptide is crucial for protease-protease interaction. PLoS ONE, 8 (9), 68014. doi:10.1371/journal.pone.0068014 |
Delbrück, H., Bogaerts, P., Kupper, M., Rezende de Castro, R., Bennik, S., Glupczynski, Y., Galleni, M., Hoffmann, K., & Bebrone, C. (November 2012). Kinetic and crystallographic studies of extended-spectrum GES-11, GES-12, and GES-14 β-lactamases. Antimicrobial Agents and Chemotherapy, 56(11), 5618-5625. doi:10.1128/AAC.01272-12 |
Scarafone, N., Pain, C., Fratamico, A., Gaspard, G., yilmaz, N., Filée, P., Galleni, M., Matagne, A., & Dumoulin, M. (March 2012). Amyloid-like fibril formation by polyQ proteins: a critical balance between the polyQ length and the constraints imposed by the host protein. PLoS ONE, 7 (3). doi:10.1371/journal.pone.0031253 |
Kupper, M., Bauvois, C., Frère, J.-M., Galleni, M., & Bebrone, C. (January 2012). The CphAII protein from Aquifex aeolicus exhibits a metal-dependent phosphodiesterase activity. Extremophiles: Life Under Extreme Conditions, 16(1), 45-55. doi:10.1007/s00792-011-0404-1 |
Sohier, J., Laurent, C., Chevigné, A., Pardon, E., Srinivasan, V., Lassaux, P., Buys, N., Willibal, K., Steyaert, J., & Galleni, M. (2012). Allosteric inhibition of VIMs metallo-β-lactamases by a camelid single-domain antibody fragment [Poster presentation]. Biomedica 2012. |
Vandevenne, M., Galleni, M., & Filée, P. (2012). How to make good use of a “bad” enzyme: utilization of efficient β-lactamases for the benefits of biochemical research. In J.-M. Frère (Ed.), β-lactamases (pp. 479-503). Indiana, United States: Nova Science. |
El Garch, F., Bogaerts, P., Bebrone, C., Galleni, M., & Glupczynski, Y. (October 2011). OXA-198, an acquired carbapenem-hydrolyzing class D beta-lactamase from Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 55(10), 4828-4833. doi:10.1128/AAC.00522-11 |
Horsfall, L., Izougarhane, Y., Lassaux, P., Selevsek, N., Liénard, B., Poirel, L., Kupper, M., Hoffmann, K., Frère, J.-M., Galleni, M., & Bebrone, C. (April 2011). Broad antibiotic resistance profile of the subclass B3 metallo-β-lactamase GOB-1, a di-zinc enzyme. FEBS Journal, 278(8), 1252-1263. doi:10.1111/j.1742-4658.2011.08046.x |
Berlemont, R., Pipers, Delsaute, M., Angiono, F., Feller, G., Galleni, M., & Power, P. (2011). Exploring the Antarctic soil metagenome as a source of novel cold-adapted enzymes and genetic mobile elements. Revista Argentina de Microbiologia. |
Dolusic, E., Larrieu, P., Blanc, S., Sapunaric, F., Norberg, B., Moineaux, L., Colette, D., Stroobant, V., Pilotte, L., Colau, D., Ferain, T., Fraser, G., Galleni, M., Frère, J.-M., Masereel, B., Van den Eynde, B., Wouters, J., & Frederick, R. (2011). Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. Bioorganic and Medicinal Chemistry, 19 (4), 1550-61. doi:10.1016/j.bmc.2010.12.032 |
Dolusic, E., Larrieu, P., Blanc, S., Sapunaric, F., Pouyez, J., Moineaux, L., Colette, D., Stroobant, V., Pilotte, L., Colau, D., Ferain, T., Fraser, G., Galleni, M., Frère, J.-M., Masereel, B., Van den Eynde, B., Wouters, J., & Frederick, R. (2011). Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. European Journal of Medicinal Chemistry, 46 (7), 3058-65. doi:10.1016/j.ejmech.2011.02.049 |
Lassaux, P., Traoré, D., Loisel, E., Favier, A., Docquier, J.-D., Sohier, J., Laurent, C., Bebrone, C., Frère, J.-M., Ferrer, J.-L., & Galleni, M. (2011). Biochemical and structural characterization of the subclass B1 metallo-β-lactamase VIM-4. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.01486-09 |
Vandevenne, M., Campisi, V., Freichels, A., Gillard, C., Gaspard, G., Frère, J.-M., Galleni, M., & Filée, P. (2011). Comparative functional analysis of the human macrophage chitotriosidase. Protein Science: A Publication of the Protein Society. doi:10.1002/pro.676 |
Vandevenne, M., GASPARD, G., Belgsir, E. M., Ramnath, M., Cenatiempo, Y., Delneuville, D., Dumoulin, M., Frère, J.-M., Matagne, A., Galleni, M., & Filee, P. (2011). Effects of monopropanediamino-beta-cyclodextrin on the denaturation process of the hybrid protein BlaPChBD. Biochimica et Biophysica Acta. doi:10.1016/j.bbapap.2011.05.007 |
Geenen, V., Mottet, M., Dardenne, O., Kermani, H., Martens, H., François, J.-M., Galleni, M., Hober, D., Rahmouni, S., & Moutschen, M. (2010). Thymic self-antigens for the design of a negative/tolerogenic self-vaccination against type 1 diabetes. Current Opinion in Pharmacology, 10, 461-472. doi:10.1016/j.coph.2010.04.005 |
Minond, D., Saldanha, S. A., Spaargaren, M., Spicer, T., Fotsing, J. R., Weide, T., Fokin, V. V., Sharpless, K. B., Galleni, M., Bebrone, C., Lassaux, P., & Hodder, P. (15 July 2009). Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries. Bioorganic and Medicinal Chemistry, 17, 5027-37. doi:10.1016/j.bmc.2009.05.070 |
Bebrone, C., Delbrück, H., Kupper, M., Schlömer, P., Willmann, C., Frère, J.-M., Fisher, R., Galleni, M., & Hoffmann, K. (2009). The structure of the di-zinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the "histidine" site. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.00288-09 |
Berlemont, R., Delsaute, M., Pipers, D., D'Amico, S., Feller, G., Galleni, M., & Power, P. (2009). Insights into bacterial cellulose biosynthesis by functional metagenomics on Antarctic soil samples. ISME Journal, 3 (9), 1070-1081. doi:10.1038/ismej.2009.48 |
Gangoue Pieboji, J., Eze, N., Ngongang Djintchui, A., Ngameni, B., Tsabang, N., Pegnyemb, D. E., Biyiti, L., Ngassam, P., Koulla-Shiro, S., & Galleni, M. (2009). The in-vitro antimicrobial activity of some medicinal plants against beta-lactam-resistant bacteria. Journal of Infection in Developing Countries, 3 (9), 671-80. doi:10.3855/jidc.77 |
Bebrone, C., Anne, C., Kerff, F., Garau, G., De Vriendt, K., Lantin, R., Devreese, B., Van Beeumen, J., Dideberg, O., Frère, J.-M., & Galleni, M. (2008). Mutational analysis of the zinc- and substrate-binding sites in the CphA metallo-beta-lactamase from Aeromonas hydrophila. Biochemical Journal, 414 (1), 151-9. doi:10.1042/BJ20080375 |
Vandevenne, M., Gaspard, G., Yilmaz, N., Giannotta, F., Frère, J.-M., Galleni, M., & Filée, P. (2008). Rapid and easy development of versatile tools to study protein/ligand interactions. Protein Engineering, Design and Selection. doi:10.1093/protein/gzn021 |
Chevigné, A., Barumandzadeh, R., Groslambert, S., Cloes, B., Dehareng, D., Filée, P., Marx, J.-C., Frère, J.-M., Matagne, A., Jacquet, A., & Galleni, M. (16 November 2007). Relationship between propeptide pH unfolding and inhibitory ability during ProDer p 1 activation mechanism. Journal of Molecular Biology, 374 (1), 170-185. doi:10.1016/j.jmb.2007.08.025 |
Horsfall, L. E., Garau, G., Lienard, B. M., Dideberg, O., Schofield, C. J., Frere, J. A., & Galleni, M. (June 2007). Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila. Antimicrobial Agents and Chemotherapy, 51 (6), 2136-2142. doi:10.1128/AAC.00866-06 |
Cornaglia, G., Akova, M., Amicosante, G., Canton, R., Cauda, R., Docquier, J.-D., Edelstein, M., Frère, J.-M., Fuzi, M., Galleni, M., Giamarellou, H., Gniadkowski, M., Koncan, R., Libisch, B., Luzzaro, F., Miriagou, V., Navarro, F., Nordmann, P., Pagani, L., ... Rossolini, G. M. (April 2007). Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues. International Journal of Antimicrobial Agents, 29 (4), 380-388. doi:10.1016/j.ijantimicag.2006.10.008 |
Lassaux, P., Hamel, M., Gulea, M., Mercuri, P., Horsfall, L., Bebrone, C., Gaumont, A.-C., Frère, J.-M., & Galleni, M. (2007). Mercapto-phosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. International Journal of Antimicrobial Agents, 29 (Supplément 2), 95. |
Vandevenne, M., Filée, P., Scarafone, N., Cloes, B., Gaspard, G., Yilmaz, N., Dumoulin, M., François, J.-M., Frère, J.-M., & Galleni, M. (2007). The Bacillus licheniformis BlaP beta-lactamase as a model protein scaffold to study the insertion of protein fragments. Protein Science: A Publication of the Protein Society, 16 (10), 2260-71. doi:10.1110/ps.072912407 |
chouchani, C., Berlemont, R., masmoudi, A., Galleni, M., Frère, J.-M., belhadj, O., & ben-mahrez, K. (September 2006). A novel extended-spectrum TEM-type beta-lactamase, TEM-138, from Salmonella enterica serovar Infantis. Antimicrobial Agents and Chemotherapy, 50 (9), 3183-5. doi:10.1128/AAC.00388-06 |
De Vriendt, K., Van Driessche, G., Devreese, B., Bebrone, C., Anne, C., Frère, J.-M., Galleni, M., & Van Beeumen, J. (February 2006). Monitoring the zinc affinity of the metallo-beta-lactamase CphA by automated nanoESI-MS. Journal of the American Society for Mass Spectrometry, 17 (2), 180-188. doi:10.1016/j.jasms.2005.10.007 |
Sauvage, E., Fonze, E., Quinting, B., Galleni, M., Frère, J.-M., & Charlier, P. (2006). Crystal structure of the Mycobacterium fortuitum class A beta-lactamase: structural basis for broad substrate specificity. Antimicrobial Agents and Chemotherapy, 50 (7), 2516-21. doi:10.1128/AAC.01226-05 |
Lenoir, S., Pagnoulle, C., Detrembleur, C., Galleni, M., & Jérôme, R. (26 October 2005). Antimicrobial activity of polyestyrene particles coated by photo-crooslinked block copolymers containing a biocidal polymethacrylate block. e-Polymers, 74, 1-11. |
Bebrone, C., Anne, C., De Vriendt, K., Devreese, B., Rossolini, G. M., Van Beeumen, J., Frère, J.-M., & Galleni, M. (05 August 2005). Dramatic broadening of the substrate profile of the Aeromonas hydrophila CphA metallo-beta-lactamase by site-directed mutagenesis. Journal of Biological Chemistry, 280 (31), 28195-28202. doi:10.1074/jbc.M414052200 |
Garau, G., Bebrone, C., Anne, C., Galleni, M., Frère, J.-M., & Dideberg, O. (28 January 2005). A metallo-beta-lactamase enzyme in action: Crystal structures of the monozinc carbapenemase CphA and its complex with biapenem. Journal of Molecular Biology, 345 (4), 785-795. doi:10.1016/j.jmb.2004.10.070 |
Frère, J.-M., Galleni, M., Bush, K., & Dideberg, O. (2005). Is it necessary to change the classification of ß-lactamases? Journal of Antimicrobial Chemotherapy, 55 (6), 1051-1053. doi:10.1093/jac/dki155 |
Power, P., Galleni, M., Di Conza, J., Ayala, J., & Gutkind, G. (2005). Description of In116, the first blaCTX-M-2-containing complex class 1 integron found in Morganella morganii isolates from Buenos Aires, Argentina. Journal of Antimicrobial Chemotherapy, 55 (4), 461-465. doi:10.1093/jac/dkh556 |
Garau, G., Garcia-Saez, I., Bebrone, C., Anne, C., Mercuri, P., Galleni, M., Frère, J.-M., & Dideberg, O. (July 2004). Update of the standard numbering scheme for class B beta-lactamases. Antimicrobial Agents and Chemotherapy, 48 (7), 2347-2349. doi:10.1128/AAC.48.7.2347-2349.2004 |
Gérard, S., Galleni, M., Dive, G., & Marchand-Brynaert, J. (02 January 2004). Synthesis and evaluation of N1/C4-substituted beta-lactams as PPE and HLE inhibitors. Bioorganic and Medicinal Chemistry, 12 (1), 129-138. doi:10.1016/j.bmc.2003.10.009 |
Vanhove, M., Zakhem, M., Devreese, B., Franceschini, N., Anne, C., Bebrone, C., Amicosante, G., Rossolini, G. M., Van Beeumen, J., Frère, J.-M., & Galleni, M. (2003). Role of Cys221 and Asn116 in the zinc-binding sites of the Aeromonas hydrophila metallo-beta-lactamase. Cellular and Molecular Life Sciences, 60 (11), 2501-9. doi:10.1007/s00018-003-3092-x |
Prosperi, C., De Seny, D., Llabres, G., Galleni, M., & Lamotte-Brasseur, J. (December 2002). Active-site mutants of class B beta-lactamases: substrate binding and mechanistic study. Cellular and Molecular Life Sciences, 59 (12), 2136-2143. doi:10.1007/s000180200013 |
De Seny, D., Prosperi, C., Bebrone, C., Rossolini, G. M., Page, M. I., Noel, P., Frère, J.-M., & Galleni, M. (01 May 2002). Mutational analysis of the two zinc-binding sites of the Bacillus cereus 569/H/9 metallo-beta-lactamase. Biochemical Journal, 363 (Pt 3), 687-696. doi:10.1042/bj3630687 |
De Seny, D., Heinz, U., Wommer, S., Kiefer, M., Meyer-Klaucke, W., Galleni, M., Frère, J.-M., Bauer, R., & Adolph, H. W. (30 November 2001). Metal Ion Binding and Coordination Geometry for Wild Type and Mutants of Metallo-Beta -Lactamase from Bacillus Cereus 569/H/9 (Bcii): A Combined Thermodynamic, Kinetic, and Spectroscopic Approach. Journal of Biological Chemistry, 276 (48), 45065-78. doi:10.1074/jbc.M106447200 |
Vilar, M., Galleni, M., Solmajer, T., Turk, B., Frère, J.-M., & Matagne, A. (August 2001). Kinetic Study of Two Novel Enantiomeric Tricyclic Beta-Lactams Which Efficiently Inactivate Class C Beta-Lactamases. Antimicrobial Agents and Chemotherapy, 45 (8), 2215-23. doi:10.1128/AAC.45.8.2215-2223.2001 |
Bebrone, C., Moali, C., Mahy, F., Rival, S., Docquier, J.-D., Rossolini, G. M., Fastrez, J., Pratt, R. F., Frère, J.-M., & Galleni, M. (June 2001). Centa as a Chromogenic Substrate for Studying Beta-Lactamases. Antimicrobial Agents and Chemotherapy, 45 (6), 1868-71. doi:10.1128/AAC.45.6.1868-1871.2001 |
Conrath, K. E., Lauwereys, M., Galleni, M., Matagne, A., Frère, J.-M., Kinne, J., Wyns, L., & Muyldermans, S. (2001). Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the camelidae. Antimicrobial Agents and Chemotherapy, 45 (10), 2807-12. doi:10.1128/AAC.45.10.2807-2812.2001 |
Rhazi, N., Galleni, M., Page, M. I., & Frère, J.-M. (15 July 1999). Peptidase Activity of Beta-Lactamases. Biochemical Journal, 341 ((Pt 2)), 409-13. doi:10.1042/0264-6021:3410409 |
Matagne, A., Dubus, A., Galleni, M., & Frère, J.-M. (February 1999). The Beta-Lactamase Cycle: A Tale of Selective Pressure and Bacterial Ingenuity. Natural Product Reports, 16 (1), 1-19. doi:10.1039/a705983c |
Prosperi, C., Llabres, G., De Seny, D., Soto, R. P., Valladares, M. H., Laraki, N., Frère, J.-M., & Galleni, M. (25 January 1999). Interaction between Class B Beta-Lactamases and Suicide Substrates of Active-Site Serine Beta-Lactamases. FEBS Letters, 443 (2), 109-11. doi:10.1016/S0014-5793(98)01689-5 |
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Matagne, A., Ledent, P., Monnaie, D., Felici, A., Jamin, M., Raquet, X., Galleni, M., Klein, D., Francois, I., & Frère, J.-M. (January 1995). Kinetic Study of Interaction between Brl 42715, Beta-Lactamases, and D-Alanyl-D-Alanine Peptidases. Antimicrobial Agents and Chemotherapy, 39 (1), 227-31. doi:10.1128/aac.39.1.227 |
Datz, M., Joris, B., Azab, E. A., Galleni, M., Van Beeumen, J., Frère, J.-M., & Martin, H. H. (1994). A common system controls the induction of very different genes. The class-A beta-lactamase of Proteus vulgaris and the enterobacterial class-C beta-lactamase. European Journal of Biochemistry, 226 (1), 149-57. doi:10.1111/j.1432-1033.1994.tb20036.x |
Granier, B., Jamin, M., Adam, M., Galleni, M., Lakaye, B., Zorzi, W., Grandchamps, J., Wilkin, J.-M., Fraipont, C., Joris, B., Duez, C., Nguyen-Distèche, M., Coyette, J., Leyh-Bouille, M., Dusart, J., Christians, L., Frère, J.-M., & Ghuysen, J.-M. (1994). Serine-Type D-Ala-D-Ala Peptidases and Penicillin-Binding Proteins. Methods in Enzymology, 244, 249-266. doi:10.1016/0076-6879(94)44021-2 |
Joris, B., Galleni, M., Frère, J.-M., & Labia, R. (1994). Analysis of the penA gene of Pseudomonas cepacia 249. Antimicrobial Agents and Chemotherapy, 38 (2), 407-8. doi:10.1128/AAC.38.2.407 |
Adam, M., Damblon, C., Jamin, M., Zorzi, W., Dusart, V., Galleni, M., El Kharroubi, A., Piras, G., Spratt, B. G., Keck, W., Coyette, J., Ghuysen, J.-M., NGuyen-Distèche, M., & Frère, J.-M. (1991). Acyltransferase activities of the high-molecular-mass essential penicillin-binding proteins. Biochemical Journal, 279 (Part 2), 601-604. doi:10.1042/bj2790601 |
Amicosante, G., Oratore, A., Joris, B., Galleni, M., Frère, J.-M., & Van Beeumen, J. (1988). Chromosome-encoded beta-lactamases of Citrobacter diversus. Interaction with beta-iodopenicillanate and labelling of the active site. Biochemical Journal, 254 (3), 891-3. doi:10.1042/bj2540891 |
Joris, B., De Meester, F., Galleni, M., Frère, J.-M., & Van Beeumen, J. (1987). The K1 beta-lactamase of Klebsiella pneumoniae. Biochemical Journal, 243 (2), 561-7. doi:10.1042/bj2430561 |
Joris, B., De Meester, F., Galleni, M., Masson, S., Dusart, J., Frère, J.-M., Van Beeumen, J., Bush, K., & Sykes, R. (1986). Properties of a class C beta-lactamase from Serratia marcescens. Biochemical Journal, 239 (3), 581-6. doi:10.1042/bj2390581 |
Joris, B., De Meester, F., Galleni, M., Reckinger, G., Coyette, J., Frère, J.-M., & Van Beeumen, J. (1985). The beta-lactamase of Enterobacter cloacae P99. Chemical properties, N-terminal sequence and interaction with 6 beta-halogenopenicillanates. Biochemical Journal, 228 (1), 241-8. doi:10.1042/bj2280241 |