Publications and communications of Thierry Grisar

Jehasse, K., Jacquerie, K., de Froidmont, A., Lemoine, C., Grisar, T., Stouffs, K., Lakaye, B., & Seutin, V. (2021). Functional analysis of the F337C mutation in the CLCN1 gene associated with dominant myotonia congenita reveals an alteration of the macroscopic conductance and voltage dependence. Molecular Genetics and Genomic Medicine, 1588. doi:10.1002/mgg3.1588

Gilsoul, M., Grisar, T., Delgado-Escueta, A. V., de Nijs, L., & Lakaye, B. (27 September 2019). Subtle brain developmental abnormalities in the pathogenesis of juvenile myoclonic epilepsy. Frontiers in Cellular Neuroscience, 13, 433. doi:10.3389/fncel.2019.00433

bailey, J., de Nijs, L., Bai, D., Suzuki, T., Miyamoto, H., Tanaka, M., Patterson, C., Lin, Y.-C., Medina, M., Alonso, M., Serratosa, J., Duron, R., Nguyen, V., Wight, J., Martinez-Juarez, I., Ochoa, A., Jara-Prado, A., Guilhoto, L., Molina, Y., ... Delgado-Escueta*. (March 2018). Variant intestinal-cell kinase in juvenile myoclonic epilepsy. New England Journal of Medicine, 378, 1018-28. doi:10.1056/NEJMoa1700175
* These authors have contributed equally to this work.

Nganou, G., Gomes Da Silva, C., Gladwyn-Ng, I., Engel, D., Coumans, B., Delgado-Escueta, A. V., Tanaka, M., Nguyen, L., Grisar, T., de Nijs, L., & Lakaye, B. (2018). Importin-8 Modulates Division of Apical Progenitors, Dendritogenesis and Tangential Migration During Development of Mouse Cortex. Frontiers in Molecular Neuroscience, 11, 234. doi:10.3389/fnmol.2018.00234

Nganou, G., Tanaka, M., Coumans, B. (Other coll.), Gomes Da Silva, C. (Other coll.), Grisar, T. (Other coll.), De Nijs, L. (Other coll.), Delgado Escueta, A. V. (Other coll.), & Lakaye, B. (Other coll.). (27 April 2017). Importin-8 could cause CAE/JME by delaying early neuroblast migration [Poster presentation]. 2nd Joint SFBD/SBCF Meeting : When Development meets Cell Biology, Lyon, France.

Bailey, J.* , Patterson, C.* , de Nijs, L., Duron, R., Ngyen, V., Tanaka, M., Medina, M., Jara-Prado, A., Martinez-Juarez, I., Ochoa, A., Molina, Y., Suzuki, T., Alonso, M., Wight, J., Lin, Y., Guilhoto, L., Yacubian, E., Machado-Salas, J., Daga, A., ... Delgado-Escueta, A. (2017). EFHC1 variants in juvenile myoclonic epilepsy: reanalysis according to NHGRI and ACMG guidelines for assigning disease causality. Genetics in Medicine, 19, 144-156. doi:10.1038/gim.2016.86
* These authors have contributed equally to this work.

Nganou, G., Tanaka, M., Coumans, B., GRISAR, T., De Nijs, L., Delgado-Escueta, A., & Lakaye, B. (December 2016). Importin-8 mutations could cause Jeavons Syndrome, CAE and JME by altering early neuroblast migration [Poster presentation]. American Epilepsy Society, Houston (TEXAS), United States.

Medard, L., Godin, J. (Other coll.), Coumans, B. (Other coll.), GRISAR, T. (Other coll.), Delgado-Escueta, A. (Other coll.), Lakaye, B. (Other coll.), & de Nijs, L. (Other coll.). (December 2015). EFHC1/Myoclonin-1 modulates the post-translational modification of microtubules [Poster presentation]. 69th Annual Meeting American Epilepsy Society, Philadelphie, United States.

Geuzaine, A., Tyhon, A., Grisar, T., Brabant, C., Lakaye, B.* , & Tirelli, E.*. (2014). Amphetamine reward in food restricted mice lacking the melanin-concentrating hormone receptor-1. Behavioural Brain Research, 262, 14-20. doi:10.1016/j.bbr.2013.12.052
* These authors have contributed equally to this work.

Esters, V., Karangwa, C., Tits, M., Francotte, P., Pirotte, B., Servais, A.-C., Fillet, M., Crommen, J., Robbrecht, E., MINET, A., Grisar, T., Angenot, L., & Frederich, M. (March 2013). Unusual Amino Acids and Monofluoroacetate from Dichapetalum michelsonii (Umutambasha), a Toxic Plant from Rwanda. Planta Medica, 79, 334-337. doi:10.1055/s-0032-1328283

de Nijs, L., Wolkoff, N., Grisar, T., & Lakaye, B. (2013). Juvenile myoclonic epilepsy as a possible neurodevelopmental disease: role of EFHC1 or Myoclonin 1. Epilepsy and Behavior, 28, 58-S60.

de Nijs, L., Wolkoff, N., Coumans, B., Delgado-Escueta, A., Grisar, T., & Lakaye, B. (2012). Mutations of EFHC1, linked to juvenile myoclonic epilepsy, disrupt radial and tangential migrations during brain development. Human Molecular Genetics, 21 (23), 5106-17. doi:10.1093/hmg/dds356

Grisar, T., Lakaye, B., de Nijs, L., LoTurco, J., Daga, A., & Delgado-Escueta, A. (2012). Myoclonin1/EFHC1 in cell division, neuroblast migration, synapse/dendrite formation in juvenile myoclonic epilepsy. In J. Noebels, M. Avoli, M. Rogawski, R. Olsen, ... A. Delgado-Escueta (Eds.), Jasper's Basic Mechanisms of the Epilepsies, 4th edition (National Center for Biotechnology Information, pp. 1-19). Bethesda (MD), United States: NCBI.

Gangolf, M., Czerniecki, J., Radermecker, M., Detry, O., NISOLLE, M., JOUAN, C., Martin, D., Chantraine, F., Lakaye, B., Wins, P., Grisar, T., & Bettendorff, L. (October 2010). Thiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells. PLoS ONE, 5 (10), 13616. doi:10.1371/journal.pone.0013616

Leon, C., de Nijs, L., Chanas, G., Delgado-Escueta, A. V., Grisar, T., & Lakaye, B. (2010). Distribution of EFHC1 or myoclonin 1 in mouse neural structures. Epilepsy Research, 88, 196-207. doi:10.1016/j.eplepsyres.2009.11.009

Pachoud, B., Adamantidis, A., Ravassard, P., Luppi, P.-H., Grisar, T., Lakaye, B., & Salin, P.-A. (2010). Major impairments of glutamatergic transmission and long term synaptic plasticity in the hippocampus of mice lacking the melanin-concentrating hormone receptor-1. Journal of Neurophysiology, 104, 1417-1425. doi:10.1152/jn.01052.2009

RIKIR, E., Grisar, T., & SADZOT, B. (2010). L’OBSERVANCE THERAPEUTIQUE DU PATIENT SOUFFRANT D’EPILEPSIE. Un problème fréquent et complexe. Revue Médicale de Liège, 65 (5-6), 370-380.

Brabant, C., Alleva, L., Grisar, T., Quertemont, E., Lakaye, B., Ohtsu, H., Lin, J.-S., Jatlow, P., Picciotto, M. R., & Tirelli, E. (2009). Effects of the H(3) receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions. Psychopharmacology, 202 (4), 673-87. doi:10.1007/s00213-008-1345-y

de Nijs, L., Leon, C., Nguyen, L., LoTurco, J. J., Delgado-Escueta, A. V., Grisar, T., & Lakaye, B. (2009). EFHC1 interacts with microtubules to regulate cell division and cortical development. Nature Neuroscience, 12 (10), 1266-74. doi:10.1038/nn.2390

Lakaye, B., Coumans, B., Harray, S., & Grisar, T. (2009). Melanin-concentrating hormone and immune function. Peptides, 30, 2076-80. doi:10.1016/j.peptides.2009.05.004

Lakaye, B., de Nijs, L., Leon, C., & Grisar, T. (2009). Cytoskeletal genes and idiopathic epilepsies. In A. Schwartzkroin (Ed.), Encyclopedia of Basic Epilepsy Research (pp. 323-329). Oxford Academic Press.

Adamantidis, A., Salvert, D., Goutagny, R., Lakaye, B., Gervasconi, D., Grisar, T., Luppi, P. H., & Fort, P. (2008). Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice. European Journal of Neuroscience, 27 (7), 1793-800. doi:10.1111/j.1460-9568.2008.06129.x

Tyhon, A.* , Lakaye, B.* , Grisar, T., & Tirelli, E. (2008). Deletion of Melanin-Concentrating Hormone Receptor-1 gene accentuates D-amphetamine-induced psychomotor activation but neither the subsequent development of sensitization nor the expression of conditioned activity in mice. Pharmacology, Biochemistry and Behavior, 88, 446-55. doi:10.1016/j.pbb.2007.10.001
* These authors have contributed equally to this work.

Coumans, B., Grisar, T., Nahon, J. L., & Lakaye, B. (04 October 2007). Effect of ppMCH derived peptides on PBMC proliferation and cytokine expression. Regulatory Peptides, 143 (1-3), 104-108. doi:10.1016/j.regpep.2007.04.001

Karangwa, C., Esters, V., Tits, M., Minet, A., Boland, A., Seutin, V., Noirfalise, A., Angenot, L., Grisar, T., & Foidart, A. (15 June 2007). Characterization of the neurotoxicity induced by the extract of Magnistipula butayei (Chrysobalanaceae) in rat: Effects of a new natural convulsive agent. Toxicon, 49 (8), 1109-1119. doi:10.1016/j.toxicon.2007.02.001

Tyhon, A., Adamantidis, A., Foidart, A., Grisar, T., Lakaye, B., & Tirelli, E. (02 October 2006). Mice lacking the melanin-concentrating hormone receptor-1 exhibit an atypical psychomotor susceptibility to cocaine and no conditioned cocaine response. Behavioural Brain Research, 173 (1), 94-103. doi:10.1016/j.bbr.2006.06.007

de Nijs, L., Lakaye, B., Coumans, B., Leon, C., Ikeda, T., Delgado-Escueta, A. V., Grisar, T., & Chanas, G. (10 September 2006). EFHC1, a protein mutated in juvenile myoclonic epilepsy, associates with the mitotic spindle through its N-terminus. Experimental Cell Research, 312 (15), 2872-2879. doi:10.1016/j.yexcr.2006.05.011

Grisar, T., de Nijs, L., Chanas, G., Leon, C., Coumans, B., Foidart, A., & Lakaye, B. (2006). Some genetic and biochemical aspects of myoclonus. Neurophysiologie Clinique, 36 (5-6, Sep-Dec), 271-279. doi:10.1016/j.neucli.2006.11.002

Van Bogaert, P., Aeby, A., De Borchgrave, V., De Cocq, C., Deprez, M., De Tiege, X., de Tourtchaninoff, M., Dubru, J.-M., Foulon, M., Ghariani, S., Grisar, T., Legros, B., Ossemann, M., Tugendhaft, P., van Rijckevorsel, K., & Verheulpen, D. (2006). The epileptic syndromes with continuous spikes and waves during slow sleep: definition and management guidelines. Acta Neurologica Belgica, 106 (2), 52-60.

Adamantidis, A., Thomas, E., Foidart, A., Tyhon, A., Coumans, B., Minet, A., Tirelli, E., Seutin, V., Grisar, T., & Lakaye, B. (15 November 2005). Disrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive and NMDA response deficit. Journal of the Neurological Sciences, 238 (Suppl. 1), 288.

Adamantidis, A., Thomas, E., Foidart, A., Tyhon, A., Coumans, B., Minet, A., Tirelli, E., Seutin, V., Grisar, T., & Lakaye, B. (2005). Disrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive deficits and alterations of NMDA receptor function. European Journal of Neuroscience, 21 (10), 2837-44. doi:10.1111/j.1460-9568.2005.04100.x

Szyniarowski, P., Lakaye, B., Czerniecki, J., Makarchikov, A. F., Wins, P., Margineanu, I., Coumans, B., Grisar, T., & Bettendorff, L. (2005). Pig tissues express a catalytically inefficient 25-kDa thiamine triphosphatase: Insight in the catalytic mechanisms of this enzyme. Biochimica et Biophysica Acta - General Subjects, 1725 (1), 93-102. doi:10.1016/j.bbagen.2005.05.026

Lakaye, B., Adamantidis, A., Coumans, B., & Grisar, T. (16 April 2004). Promoter characterization of the mouse melanin-concentrating hormone receptor 1. Biochimica et Biophysica Acta-Gene Structure and Expression, 1678 (1), 1-6. doi:10.1016/j.bbaexp.2004.01.006

Czerniecki, J., Chanas, G., Verlaet, M., Bettendorff, L., Makarchikov, A. F., Leprince, P., Wins, P., Grisar, T., & Lakaye, B. (2004). Neuronal localization of the 25-kDa specific thiamine triphosphatase in rodent brain. Neuroscience, 125 (4), 833-840. doi:10.1016/j.neuroscience.2004.02.033

Lakaye, B., Makarchikov, A. F., Wins, P., Margineanu, I., Roland, S., Lins, L., Aichour, R., Lebeau, L., Elmoualij, B., Zorzi, W., Coumans, B., Grisar, T., & Bettendorff, L. (2004). Human recombinant thiamine triphosphatase: purification, secondary structure and catalytic properties. International Journal of Biochemistry and Cell Biology, 36 (7), 1348-1364. doi:10.1016/j.biocel.2003.11.013

Lakaye, B., Verlaet, M., Dubail, J., Czerniecki, J., Bontems, S., Makarchikov, A. F., Wins, P., Piette, J., Grisar, T., & Bettendorff, L. (2004). Expression of 25 kDa thiamine triphosphatase in rodent tissues using quantitative PCR and characterization of its mRNA. International Journal of Biochemistry and Cell Biology, 36 (10), 2032-2041. doi:10.1016/j.biocel.2004.03.004

Lakaye, B., Wirtzfeld, B., Wins, P., Grisar, T., & Bettendorff, L. (2004). Thiamine triphosphate, a new signal required for optimal growth of Escherichia coli during amino acid starvation. Journal of Biological Chemistry, 279 (17), 17142-17147. doi:10.1074/jbc.M313569200

Makarchikov, A. F., Lakaye, B., Gulyai, I. E., Czerniecki, J., Coumans, B., Wins, P., Grisar, T., & Bettendorff, L. (2003). Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals. Cellular and Molecular Life Sciences, 60 (7), 1477-1488. doi:10.1007/s00018-003-3098-4

Wins, P., Margineanu, I., Penelle, J., Angenot, L., Grisar, T., & Bettendorff, L. (2003). Bisindole alkaloids from Strychnos guianensis are effective antagonists of nicotinic acetylcholine receptors in cultured human TE671 cells. Naunyn-Schmiedeberg's Archives of Pharmacology, 367 (3), 253-259. doi:10.1007/s00210-003-0692-9

Verlaet, M., Adamantidis, A., Coumans, B., Chanas, G., Zorzi, W., Heinen, E., Grisar, T., & Lakaye, B. (11 September 2002). Human immune cells express ppMCH mRNA and functional MCHR1 receptor. FEBS Letters, 527 (1-3), 205-210. doi:10.1016/S0014-5793(02)03232-5

Bettendorff, L., Lakaye, B., Margineanu, I., Grisar, T., & Wins, P. (2002). ATP-driven, Na(+)-independent inward Cl- pumping in neuroblastoma cells. Journal of Neurochemistry, 81 (4), 792-801. doi:10.1046/j.1471-4159.2002.00858.x

Lakaye, B., Makarchikov, A. F., Antunes, A. F., Zorzi, W., Coumans, B., De Pauw, E., Wins, P., Grisar, T., & Bettendorff, L. (2002). Molecular characterization of a specific thiamine triphosphatase widely expressed in mammalian tissues. Journal of Biological Chemistry, 277 (16), 13771-13777. doi:10.1074/jbc.M111241200

Lakaye, B., Thomas, E., Minet, A., & Grisar, T. (2002). The genetic absence epilepsy rat from Strasbourg (GAERS), a rat model of absence epilepsy: Computer modeling and differential gene expression. Epilepsia, 43 (Suppl. 5), 123-129. doi:10.1046/j.1528-1157.43.s.5.17.x

Makarchikov, A. F., Wins, P., Janssen, E., Wieringa, B., Grisar, T., & Bettendorff, L. (2002). Adenylate kinase 1 knockout mice have normal thiamine triphosphate levels. BBA Molecular Cell Research, 1592 (2), 117-121. doi:10.1016/S0167-4889(02)00277-X

Lakaye, B., de Borman, B., Minet, A., Arckens, L., Vergnes, M., Marescaux, C., & Grisar, T. (March 2000). Increased Expression of mRNA Encoding Ferritin Heavy Chain in Brain Structures of a Rat Model of Absence Epilepsy. Experimental Neurology, 162 (1), 112-20. doi:10.1006/exnr.2000.7303

Lahmouzi, J., Simain-Sato, F., Defresne, M.-P., De Pauw-Gillet, M.-C., Heinen, E., Grisar, T., Legros, J.-J., & Legrand, R. (2000). Effect of nicotine on rat gingival fibroblasts in vitro. Connective Tissue Research, 41 (1), 69-80. doi:10.3109/03008200009005643

Simain-Sato, F., Lahmouzi, J., Kalykakis, G. K., Heinen, E., Defresne, M.-P., De Pauw, M. C., Grisar, T., Legros, J.-J., & Legrand, R. (October 1999). Culture of Gingival Fibroblasts on Bioabsorbable Regenerative Materials in Vitro. Journal of Periodontology, 70 (10), 1234-9. doi:10.1902/jop.1999.70.10.1234

Foidart, A., Lakaye, B., Grisar, T., Ball, G. F., & Balthazart, J. (05 September 1999). Estrogen Receptor-Beta in Quail: Cloning, Tissue Expression and Neuroanatomical Distribution. Journal of Neurobiology, 40 (3), 327-42. doi:10.1002/(SICI)1097-4695(19990905)40:3<327::AID-NEU5>3.0.CO;2-L

de Borman, B., Lakaye, B., Minet, A., Zorzi, W., Vergnes, M., Marescaux, C., & Grisar, T. (10 February 1999). Expression of Mrna Encoding Alpha1e and Alpha1g Subunit in the Brain of a Rat Model of Absence Epilepsy. Neuroreport, 10 (3), 569-74. doi:10.1097/00001756-199902250-00023

Grisar, T., Lakaye, B., Thomas, E., Bettendorff, L., & Minet, A. (1999). The Molecular Neuron-Glia Couple and Epileptogenesis. Advances in Neurology, 79, 591-602.

Grisar, T., Lakaye, B., Thomas, E., Bettendorff, L., & Minet, A. (1999). The molecular neuron-glia couple and epileptogenesis. In A. V. Delgado-Escueta, W. A. Wilson, R. W. Olsen, ... R. J. Porter (Eds.), Jasper's Basic Mechanisms of the Epilepsies, 3rd edition. Philadelphia, United States - Pennsylvania: Lippincott Williams & Wilkins.

Simain-Sato, F., Lahmouzi, J., Heinen, E., Defresne, M.-P., De Pauw-Gillet, M.-C., Grisar, T., Legros, J.-J., & Legrand, R. (1999). Graft of autologous fibroblasts in gingival tissue in vivo after culture in vitro. Preliminary study on rats. Journal of Periodontal Research, 34 (6), 323-8. doi:10.1111/j.1600-0765.1999.tb02260.x

Thellin, O., Zorzi, W., Lakaye, B., De Borman, B., Coumans, B., Hennen, G., Grisar, T., Igout, A., & Heinen, E. (1999). Housekeeping Genes as Internal Standards: Use and Limits. Journal of Biotechnology, 75 (2-3), 291-5. doi:10.1016/S0168-1656(99)00163-7

Lakaye, B., Foidart, A., Grisar, T., & Balthazart, J. (24 August 1998). Partial Cloning and Distribution of Estrogen Receptor Beta in the Avian Brain. Neuroreport, 9 (12), 2743-8. doi:10.1097/00001756-199808240-00011

Lakaye, B., Minet, A., Zorzi, W., & Grisar, T. (10 February 1998). Cloning of the Rat Brain Cdna Encoding for the Slc-1 G Protein-Coupled Receptor Reveals the Presence of an Intron in the Gene. Biochimica et Biophysica Acta, 1401 (2), 216-20. doi:10.1016/S0167-4889(97)00135-3

Bettendorff, L., Mastrogiacomo, F., Wins, P., Kish, S. J., Grisar, T., & Ball, M. J. (1997). Low Thiamine Diphosphate Levels in Brains of Patients with Frontal Lobe Degeneration of the Non-Alzheimer's Type. Journal of Neurochemistry, 69 (5), 2005-2010. doi:10.1046/j.1471-4159.1997.69052005.x

Grisar, T., Lakaye, B., & Thomas, E. (October 1996). Molecular Basis of Neuronal Biorhythms and Paroxysms. Archives of Physiology and Biochemistry, 104 (6), 770-4. doi:10.1076/apab.104.6.770.12915

Bettendorff, L., Mastrogiacomo, F., Kish, S. J., & Grisar, T. (1996). Thiamine, Thiamine Phosphates, and Their Metabolizing Enzymes in Human Brain. Journal of Neurochemistry, 66 (1), 250-8. doi:10.1046/j.1471-4159.1996.66010250.x

Mastrogiacomo, F., Bettendorff, L., Grisar, T., & Kish, S. J. (1996). Brain thiamine, its phosphate esters, and its metabolizing enzymes in Alzheimer's disease. Annals of Neurology, 39, 585-591. doi:10.1002/ana.410390507

Bettendorff, L., Goessens, G., Sluse, F., Wins, P., Bureau, M., Laschet, J., & Grisar, T. (1995). Thiamine Deficiency in Cultured Neuroblastoma Cells: Effect on Mitochondrial Function and Peripheral Benzodiazepine Receptors. Journal of Neurochemistry, 64 (5), 2013-2021. doi:10.1046/j.1471-4159.1995.64052013.x

Bettendorff, L., Margineanu, I., Wins, P., & Grisar, T. (1995). An Atypical Anion Transporter Functioning at Acid pH in Neuroblastoma Cells. Biochemical and Biophysical Research Communications, 207 (1), 375-381. doi:10.1006/bbrc.1995.1198

Bettendorff, L., Sluse, F., Goessens, G., Wins, P., & Grisar, T. (1995). Thiamine Deficiency--Induced Partial Necrosis and Mitochondrial Uncoupling in Neuroblastoma Cells Are Rapidly Reversed by Addition of Thiamine. Journal of Neurochemistry, 65 (5), 2178-2184. doi:10.1046/j.1471-4159.1995.65052178.x

Franck, G., Maquet, P., Sadzot, B., Salmon, E., Debets, R., Dive, D., Grisar, T., Guillaume, D., Van Veelen, C., & Van Huffelen, A. (1992). Contribution of Positron Emission Tomography to the Investigation of Epilepsies of Frontal Lobe Origin. Advances in Neurology, 57, 471-85.

Franck, G., Doyen, P., Grisar, T., & Moonen, G. (20 October 1983). Cerebral ischemic accidents in young patients, less than 45 years of age. Semaine des Hôpitaux de Paris. Thérapeutique, 59 (37-38), 2642-2644.

ANSSEAU, M., Diricq, S., Grisar, T., & Collard, J. (1981). The malignant syndrome of neuroleptics: neuroendocrine and biochemical approaches. Neuroendocrinology Letters, 3 (2), 124.

ANSSEAU, M., Diricq, S., Grisar, T., & Collard, J. (1980). Biochemical and neuroendocrine approaches to a malignant syndrome of neuroleptics. Acta Psychiatrica Belgica, 80 (5), 600-606.

Franck, G., CORNETTE, M., Grisar, T., MOONEN, G., & GEREBTZOFF, M. A. (July 1974). The stiff-man syndrome. Clinical, polygraphical and histoenzymological study (author's transl). Acta Neurologica Belgica, 74 (4), 221-40.