Publications and communications of Frédéric LAMBERT

Lambert, F., KOOPMANSCH, B., Fernandez Carazo, R., DARDENNE, E., Keutgens, A., Vanstraelen, G., Collins, P., MENTEN, C., & VERTENOEIL, G. (24 April 2026). Partner-agnostic targeted RNA sequencing confirms a rare TPM3::PDGFRB fusion in MLN-TK with eosinophilia: a three-phase clinical course under imatinib [Poster presentation]. 11th Translational Research Conference MYELOPROLIFERATIVE NEOPLASMS April 24-26, 2026 Estoril, Portugal #ESHMPN2026, Estoril, Portugal.

Lambert, F., KOOPMANSCH, B., Fernandez Carazo, R., DARDENNE, E., CARPEAUX, R., Keutgens, A., Vanstraelen, G., Collins, P., MENTEN, C., & VERTENOEIL, G. (23 April 2026). TPM3::PDGFRB-rearranged MLN-TK with associated hematologic neoplasm: a three-phase clinical course supporting upfront NGS profiling [Poster presentation]. 11th TRANSLATIONAL RESEARCH CONFERENCE MYELOPROLIFERATIVE NEOPLASMS, Estoril, Portugal.

DUYSINX, J., Willems, E., Baron, F., LEJEUNE, M., Lambert, F., Somja, J., Collins, P., DE PRIJCK, B.* , & De Voeght, A. (February 2026). Clinical management of myeloid sarcoma in a single-center cohort [Poster presentation]. 41st General Annual Meeting of the Belgian Hematology Society 2026, Brussels, Belgium.

Reynders, C., Bruyère, D., RONCARATI, P., Geuzaine, R., KOOPMANSCH, B., Gofflot, S., Monnien, F., Craciun, L., Piazzon, N., Hendrick, E., Poulain, F., Lerho, T., Miceli, S., Pilard, C., Ancion, M., Luyckx, M., Renard, M., Lambert, F., Gheit, T., ... Herfs, M. (December 2025). Human Papillomavirus Infection Is a Favorable Prognostic Factor for Patients With Stages I to IVA Esophageal Squamous Cell Carcinoma but not Adenocarcinoma. Modern Pathology, 38 (12), 100853. doi:10.1016/j.modpat.2025.100853

Vertenoeil, G., HAFRAOUI, K., Collins, P., Somja, J., Lambert, F., De Worm, S., & Beguin, Y. (2025). Whipple's Disease Presenting with Bone Marrow Findings Mimicking Prefibrotic Myelofibrosis: A Diagnostic Pitfall. International Journal of Infectious Diseases, 108271. doi:10.1016/j.ijid.2025.108271

Lopez Delhoulle, V., De Voeght, A., NECHIFOR - POTORAC, I., Sépulchre, E., Willems, E., Pétrossians, P., Fernandez Carazo, R., KOOPMANSCH, B., Docampo Martínez, E., Bours, V., Bulk, S.* , & Lambert, F.*. (16 October 2025). A Spectrum of Tumorigenesis in an IDH1-Mosaic Patient with Ollier Disease [Poster presentation]. 7th INTERNATIONAL CONFERENCE ACUTE MYELOID LEUKEMIA “MOLECULAR AND TRANSLATIONAL”: ADVANCES IN BIOLOGY AND TREATMENT, Estoril, Portugal.

Malaise, O., Lambert, F., Damsin, T., GESTER, F., PAQUOT, C., & VERTENOEIL, G. (02 February 2025). Syndrome de VEXAS [Paper presentation]. GLEM du service de rhumatologie du CHU de Liège.

Malaise, O., Von Frenckell, C., Mina, M., Rinkin, C., DAMSIN, T., GESTER, F., El Moussaoui, M., PAQUOT, C., Lambert, F., De Voeght, A., Ribbens, C., & VERTENOEIL, G. (18 September 2024). VEXAS syndrome: at the intersection between rheumatology and hematology. But have we thought about inviting the dermatologist? [Poster presentation]. Belgian Congress of Rheumatology 2024.

Nokin, M.-J., Darbo, E., Richard, E., San José, S., de Hita, S., Prouzet-Mauleon, Turcs, B., Gerardelli, L., Crake, R., Velasco, V., KOOPMANSCH, B., Lambert, F., Xue, J. Y., Sang, B., Horne, J., Ziemons, E., Villanueva, A., Blomme, A., Herfs, M., ... Santamaria, D. (2024). In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma. Cell Reports Medicine. doi:10.1016/j.xcrm.2024.101663

Catarin, N., LETE, C., Fernandez Carazo, R., KOOPMANSCH, B., Franke, S., LLORENTE, W., GUADAGNI, A., Bours, V., Beckers, P., JAMAR, M., Lambert, F., & MENTEN, C. (2024). Optical genome mapping (Bionano – Saphyr) for AML associated with cryptic chromosomal recurrent abnormality. Belgian Journal of Hematology.

Pirotte, M., De Voeght, A., VERTENOEIL, G., Vasbien Myriam, Paridaens, H., Somja, J., Collins, P., & Lambert, F. (December 2023). VACUOLES, E1 ENZYME, X-LINKED, AUTOINFLAMMATORY, SOMATIC SYNDROME (VEXAS SYNDROME) WITH MULTIPLE THROMBOEMBOLISM EVENTS: A BELGIAN CASE REPORT. Belgian Journal of Hematology, 14 (8), 336–42.

Vermeersch, G., Devos, T., Devos, H., Lambert, F., Poppe, B., & Van Hecke, S. (20 September 2023). Germline heterozygous SH2B3-mutations and (idiopathic) erythrocytosis: Detection of a previously undescribed mutation. EJHaem, 4 (4), 1143 - 1147. doi:10.1002/jha2.800

Crake, R., Gasmi, I., Dehaye, J., Lardinois, F., Peiffer, R., Maloujahmoum, N., Agirman, F., KOOPMANSCH, B., D’Haene, N., Azurmendi Senar, O., Arsenijevic, T., Lambert, F., Peulen, O., Van Laethem, J.-L., & Bellahcene, A. (17 May 2023). Resistance to Gemcitabine in Pancreatic Cancer Is Connected to Methylglyoxal Stress and Heat Shock Response. Cells, 12 (10), 1414. doi:10.3390/cells12101414

LETE, C., FERNANDEZ CARAZO, R., MENTEN, C., BECKERS, P., KOOPMANSCH, B., FRANKE, S., DE PRIJCK, B., JAMAR, M., LAMBERT, F., & BOURS, V. (July 2021). A case of early-T-cell precursor acute lymphoblastic leukemia with e6a2 BCR-ABL1 fusion transcript [Poster presentation]. 13th European Cytogenomics Conference.

Hebran, A., & Lambert, F. (June 2021). Genetic and molecular biology in pancreatobiliary cancers: Testing for pancreatobiliary cancer in the context of the Belgian NGS convention. Belgian Journal of Medical Oncology, 15 (4), 170-176.

DOCAMPO MARTINEZ, E., MARTIN, M., GANGOLF, M., HARVENGT, J., BULK, S., SEGERS, K., LEROI, N., LETE, C., PALMARICCIOTTI, V., Freire Chadrina, M., LAMBERT, F., & Bours, V. (2021). Hérédité et cancer. Revue Médicale de Liège, 76 (5-6), 327-336.

Trimech, M., Letourneau, A., Missiaglia, E., DE PRIJCK, B., Nagy-Hulliger, M., SOMJA, J., Vivario, M., Gaulard, P., LAMBERT, F., Bisig, B., & de Leval, L. (2021). Angioimmunoblastic T-Cell Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Novel Form of Composite Lymphoma Potentially Mimicking Richter Syndrome. American Journal of Surgical Pathology, 45, 773-786. doi:10.1097/PAS.0000000000001646

Bellier, J., Nokin, M.-J., Caprasse, M., Tiamiou, A., Blomme, A., Scheijen, J. L., KOOPMANSCH, B., MacKay, G. M., Chiavarina, B., Costanza, B., Rademaker, G., Durieux, F., Agirman, F., Maloujahmoum, N., Cusumano, P. G., LOVINFOSSE, P., Leung, H. Y., LAMBERT, F., Bours, V., ... Bellahcene, A. (04 February 2020). Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab. Cell Reports, 30 (5), 1400-1416.e6. doi:10.1016/j.celrep.2020.01.012

FERNANDEZ CARAZO, R., KOOPMANSCH, B., PALMEIRA, L., CHARLOTEAUX, B., & LAMBERT, F. (2020). Hematopoietic Malignancies with Germline Predisposition Diagnosis with Filtered Whole Exome Sequencing and in silico Panel Analysis [Poster presentation]. European School of Haematology 2020.

Herfs, M., RONCARATI, P., KOOPMANSCH, B., Peulen, O., Bruyère, D., Lebeau, A., Hendrick, E., Hubert, P., PONCIN, A., Penny, W., Piazzon, N., Monnien, F., Guenat, D., Mougin, C., Prétet, J.-L., Vuitton, L., SEGERS, K., LAMBERT, F., BOURS, V., ... Delvenne, P. (2018). A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalized medicine. British Journal of Cancer, 118(10), 1302-1312. doi:10.1038/s41416-018-0049-2

LOVINFOSSE, P., POLUS, M., VAN DAELE, D., Martinive, P., DAENEN, F., Hatt, M., Visvikis, D., KOOPMANSCH, B., LAMBERT, F., COIMBRA MARQUES, C., SEIDEL, L., Albert, A., Delvenne, P., & Hustinx, R. (2018). FDG PET/CT radiomics for predicting the outcome of locally advanced rectal cancer. European Journal of Nuclear Medicine and Molecular Imaging. doi:10.1007/s00259-017-3855-5

Delefortrie, Q., LAMBERT, F., Bulliard, G., Jurdan, M., Toffoli, S., Sartenaer, D., Theate, I., de Prophetis, S., Pranger, D., Konreich, A., & Mineur, P. (2017). A 54-year-old woman with a myeloid neoplasm associated with eosinophilia and t(5;12)(q33;p13)/PDFRFB rearrangement : case report and mini-review of the literature. Clinical Medical Reviews and Case Reports. doi:10.23937/2378-3656/1410170

KOOPMANSCH, B., LOPEZ Y CADENAS, M., Hennuy, B., & LAMBERT, F. (29 January 2016). Identification of a TPM3-PDGFRB fusion transcript and its chromosomal breakpoints by RNA-Seq in a case of Chronic Eosinophilic Leukemia [Poster presentation]. BHS General Annual Meeting 2016, United States - Texas.

SAGOT, C., CHARLIER, H., KOOPMANSCH, B., & LAMBERT, F. (29 January 2016). Two cases of atypical CALR mutations in MPN patients [Poster presentation]. BHS General annual meeting 2016.

LOVINFOSSE, P., KOOPMANSCH, B., LAMBERT, F., JODOGNE, S., KUSTERMANS, G., Hatt, M., Visvikis, D., SEIDEL, L., POLUS, M., Albert, A., DELVENNE, P., & HUSTINX, R. (2016). 18F-FDG PET/CT imaging in rectal cancer: relationship with the RAS mutational status. British Journal of Radiology, 20160212. doi:10.1259/bjr.20160212

Maes, B., Bakkus, M., Boeckx, N., Boone, E., Cauwelier, B., Denys, B., De Schouwer, P., Devos, T., El Housni, H., Hillen, F., Jacobs, K., LAMBERT, F., Louagie, H., Maes, M.-B., Meeus, P., Moreau, E., Nollet, F., Peeters, K., Saussoy, P., ... Bruyndonckx, R. (2016). A novel approach for BCR-ABL1 standardization to improve International Scale estimation. International Journal of Laboratory Hematology, 38 (6), 674-684. doi:10.1111/ijlh.12556

Roufosse, F., Heimann, P., LAMBERT, F., Sidon, P., Bron, D., Cottin, V., & Cordier, J.-F. (2016). Severe Prolonged Cough as Presenting Manifestation of FIP1L1-PDGFRA+ Chronic Eosinophilic Leukaemia: A Widely Ignored Association. Respiration: International Review of Thoracic Diseases. doi:10.1159/000446076

DIDEBERG, V., SEGERS, K., KOOPMANSCH, B., LAMBERT, F., & Bours, V. (2015). PHARMACOGENOMIQUE ET MEDECINE PERSONNALISEE : VERS UN SCREENING SYSTEMATIQUE DE LA POPULATION ? Revue Médicale de Liège, 70 (5-6), 251-6.

FOGUENNE, J., SIMUL, M., KEUTGENS, A., TASSIN, F., Bonnet, C., BEGUIN, Y., JAMAR, M., LAMBERT, F., & GOTHOT, A. (2015). Multiparameter flow cytometric analysis of composite lymphoma: case report of a mantle cell lymphoma associated with a B-cell chronic lymphocytic leukemia and an aberrant T cell subset. Belgian Journal of Hematology.

JERUSALEM, G., COLLIGNON, J., Josse, C., SCHROEDER, H., RORIVE, A., FRERES, P., LAMBERT, F., KOOPMANSCH, B., PONCIN, A., & BOURS, V. (2015). Cancer du sein : de la thérapie ciblée à la médecine personnalisée. Revue Médicale de Liège, 70 (5-6), 269-276.

CAERS, J., HAFRAOUI, K., KEUTGENS, A., CABERG, J.-H., LAMBERT, F., TASSIN, F., & BEGUIN, Y. (02 February 2014). Haematological and molecular responses in refractory anaemia with ring sideroblasts and thrombocytosis treated with lenalidomide. European Journal of Haematology, 92 (2), 179-180. doi:10.1111/ejh.12233

Bento, C., Percy, M. J., Gardie, B., Maia, T. M., van Wijk, R., Perrotta, S., Della Ragione, F., Almeida, H., Rossi, C., Girodon, F., Astrom, M., Neumann, D., Schnittger, S., Landin, B., Minkov, M., Randi, M. L., Richard, S., Casadevall, N., Vainchenker, W., ... Ugo, V. (2014). Genetic basis of congenital erythrocytosis: mutation update and online databases. Human Mutation, 35 (1), 15-26. doi:10.1002/humu.22448

Gardie, B., Percy, M. J., Hoogewijs, D., Chowdhury, R., Bento, C., Arsenault, P. R., Richard, S., Almeida, H., Ewing, J., Lambert, F., McMullin, M. F., Schofield, C. J., & Lee, F. S. (2014). The role of PHD2 mutations in the pathogenesis of erythrocytosis. Hypoxia, 2, 71 - 90. doi:10.2147/HP.S54455

Bonnet, C., MENTEN, C., LAMBERT, F., Gothot, A., Baron, F., CAERS, J., HERENS, C., & Beguin, Y. (25 January 2013). Simultaneous diagnosis of CLL and CML in a single patient with evidence for two different cell clones [Poster presentation]. BHS, General Annual Meeting.

Rozen, L., Huybrechts, S., Dedeken, L., Heijmans, C., Dessars, B., Heimann, P., LAMBERT, F., Noubouossie, D. F., Ferster, A., & Demulder, A. (2013). Transient leukemia in a newborn without Down syndrome: case report and review of the literature. European Journal of Pediatrics. doi:10.1007/s00431-013-2163-8

De Weer, A., Van der Meulen, J., Rondou, P., Taghon, T., Konrad, T. A., De Preter, K., Mestdagh, P., Van Maerken, T., Van Roy, N., Jeison, M., Yaniv, I., Cauwelier, B., Noens, L., Poirel, H.-A., Vandenberghe, P., LAMBERT, F., De Paepe, A., Sanchez Mainar, M., Odero, M., ... Speleman, F. (2011). EVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells. British Journal of Haematology, 154 (3), 337-48. doi:10.1111/j.1365-2141.2011.08737.x

Duhoux, F. P., Ameye, G., Lambot, V., HERENS, C., LAMBERT, F., Raynaud, S., Wlodarska, I., Michaux, L., Roche-Lestienne, C., Labis, E., Taviaux, S., Chapiro, E., Khac, F. N., Struski, S., Dobbelstein, S., Dastugue, N., Lippert, E., Speleman, F., Van Roy, N., ... Poirel, H. A. (2011). Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies. PLoS ONE, 6 (10), 26311. doi:10.1371/journal.pone.0026311

Robert, I., Aussems, M., Keutgens, A., Zhang-Shao, X., Hennuy, B., Viatour, P., Vanstraelen, G., Merville, M.-P., Chapelle, J.-P., de Leval, L., LAMBERT, F., Dejardin, E., Gothot, A., & Chariot, A. (02 April 2009). Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-κB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes. Oncogene, 28 (13), 1626-1638. doi:10.1038/onc.2009.6

Nollet, F., Bakkus, M., Meeus, P., Demanet, C., Schaaf-Lafontaine, N., FRANKE, S., Chatelain, B., Vermeulen, K., Boone, E., El Housni, H., Heimann, P., Husson, B., LAMBERT, F., Vannuffel, P., Saussoy, P., Maes, B., & Deschouwer, P. (2009). Guidelines for an integrated diagnostic approach of chronic lymphoproliferative disorders in the routine laboratory of haematology in Belgium. Acta Clinica Belgica, 64 (6), 494-504. doi:10.1179/acb.2009.085

Herens, C., Lambert, F., Quintanilla-Martinez, L., Bisig, B., Deusings, C., & De Leval, L. (2008). Cyclin D1-negative mantle cell lymphoma with cryptic t(12;14)(p13;q32) and cyclin D2 overexpression. Blood, 111 (3), 1745-6. doi:10.1182/blood-2007-10-120824

Lambert, F., Heimann, P., Herens, C., Chariot, A., & Bours, V. (July 2007). Consultations in molecular diagnostics - A case of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia with a rare FIP1L1 breakpoint. Journal of Molecular Diagnostics, 9 (3), 414-419. doi:10.2353/jmoldx.2007.060196

Lahortiga, I., De Keersmaecker, K., Van Vlierberghe, P., Graux, C., Cauwelier, B., Lambert, F., Mentens, N., Beverloo, H. B., Pieters, R., Speleman, F., Odero, M. D., Bauters, M., Froyen, G., Marynen, P., Vandenberghe, P., Wlodarska, I., Meijerink, J. P. P., & Cools, J. (June 2007). Duplication of the MYB oncogene in T-cell acute lymphoblastic leukemia. Haematologica, 92 (Suppl. 1), 164.

Lahortiga, I., De Keersmaecker, K., Van Vlierberghe, P., Graux, C., Cauwelier, B., Lambert, F., Mentens, N., Beverloo, H. B., Pieters, R., Speleman, F., Odero, M. D., Bauters, M., Froyen, G., Marynen, P., Vandenberghe, P., Wlodarska, I., Meijerink, J. P. P., & Cools, J. (May 2007). Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nature Genetics, 39 (5), 593-595. doi:10.1038/ng2025

Robe, P., Nguyen-Khac, M.-T., Lambert, F., Lechanteur, C., Jolois, O., Ernst-Gengoux, P., Rogister, B., & Bours, V. (January 2007). Sufasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. International Journal of Oncology, 30 (1), 283-290. doi:10.3892/ijo.30.1.283

Lahortiga, I., Graux, C., Mentens, N., Van Roosbroeck, K., De Keersmaecker, K., Lambert, F., Vandenberghe, P., Wlodarska, I., Froyen, G., Odero, M. D., Marynen, P., & Cools, J. (16 November 2006). Array-CGH analysis of T-ALL patients and cell lines. Blood, 108 (11, Part 2), 195B-196.

Sidon, P., Heimann, P., Lambert, F., Dessars, B., Robin, V., & El Housni, H. (July 2006). Combined locked nucleic acid and molecular beacon technologies for sensitive detection of the JAK2(V617F) somatic single-base sequence variant. Clinical Chemistry, 52 (7), 1436-1438. doi:10.1373/clinchem.2006.066886

Dessars, B., El Housni, H., Lambert, F., Kentos, A., & Heimann, P. (May 2006). Rational use of the EAC real-time quantitative PCR protocol in chronic myelogenous leukemia: report of three false-negative cases at diagnosis. Leukemia, 20 (5), 886-888. doi:10.1038/sj.leu.2404174

Lambert, F., Schioppa, A., Castermans, S., Lopez, M.-J., Chariot, A., & Bours, V. (2006). Accurate genotyping of the V617F janus kinase (JAK) 2 mutation combining ARMS PCR and capillary electrophoresis. Acta Clinica Belgica, 61 (2, MAR-APR), 108.

Jacquy, C., Soree, A., Lambert, F., Bosly, A., Ferrant, A., Andre, M.-E., Parma, J., Kentos, A., & Martiat, P. (2000). A quantitative study of peripheral blood stem cell contamination in diffuse large-cell non-Hodgkin's lymphoma: one-half of patients significantly mobilize malignant cells. British Journal of Haematology, 110 (3), 631-7. doi:10.1046/j.1365-2141.2000.02244.x

Jacquy, C., Lambert, F., Soree, A., Van Daele, S., Heusterspreute, M., Bosly, A., Ferrant, A., Parma, J., Bron, D., & Martiat, P. (1999). Peripheral blood stem cell contamination in mantle cell non-Hodgkin lymphoma: the case for purging? Bone Marrow Transplantation, 23 (7), 681-6. doi:10.1038/sj.bmt.1701637