Publications and communications of Francesca Rapino

Joiret, M., Kerff, F., Rapino, F., Close, P., & Geris, L. (July 2023). A simple geometrical model of the electrostatic environment around the catalytic center of the ribosome and its significance for the elongation cycle kinetics. Computational and Structural Biotechnology Journal, 21, 3768-3795. doi:10.1016/j.csbj.2023.07.016

Capron, C., Martin Morales, L., & Rapino, F. (17 May 2023). Novel bioinformatics mRNA translation multi-omics analysis identifies key features of the intestinal cancer stem cells [Poster presentation]. Gordon Research Conference - Stem Cells and Cancer, Lucca, Italy.

Martin Morales, L., Capron, C., & Rapino, F. (14 May 2023). Unveiling the role of tRNA modifications in the establishment of intestinal Cancer Stem Cells [Poster presentation]. Stem Cells and Cancer GRC: Strategies for Controlling Development, Tissue Homeostasis and Cancer, Lucca, Italy.

Joiret, M., Leclercq, M., Lambrechts, G., Rapino, F., Close, P., Louppe, G., & Geris, L. (06 April 2023). Cracking the genetic code with neural networks. Frontiers in Artificial Intelligence, 6. doi:10.3389/frai.2023.1128153

Joiret, M., Leclercq, M., Lambrechts, G., Rapino, F., Close, P., Louppe, G., & Geris, L. (2023). Cracking the genetic code with neural networks (poster) [Paper presentation]. Neural networks: real versus man-made, Liège, Belgium.

Joiret, M., Rapino, F., Close, P., & Geris, L. (06 September 2022). A simple model of the electrostatic environment around the catalytic center of the ribosome and its significance for the elongation kinetics [Poster presentation]. Translational Control meeting, Cold Spring Harbor, New-York, United States - New York.

Martin Morales, L., Capron, C., & Rapino, F. (12 June 2022). Translation-dependent establishment of intestinal Cancer Stem Cells [Poster presentation]. 28th tRNA Conference, Columbus, United States - Ohio.

Martin Morales, L., Capron, C., & Rapino, F. (13 May 2022). Translation-dependent establishment of intestinal Cancer Stem Cells [Poster presentation]. 7th Annual Meeting of the Belgian Society for Stem Cell Research, Liège, Belgium.

Joiret, M., Kerff, F., Rapino, F., Close, P., & Geris, L. (13 January 2022). Ribosome exit tunnel electrostatics. Physical Review. E, 105 (1), 014409-1 - 014409-43. doi:10.1103/PhysRevE.105.014409

Capron, C., & Rapino, F. (2022). Bioinformatics dissection of translational landscape of intestinal cell differentiation [Poster presentation]. 7th Annual Meeting of the Belgian Society for Stem Cell Research, Liège, Belgium.

Joiret, M., Rapino, F., Close, P., & Geris, L. (09 September 2021). Ribosome exit tunnel electrostatics [Poster presentation]. EMBO - Workshop - Protein synthesis and translational control, Heidelberg, Germany.

Rapino, F.* , ZHOU, Z.* , RONCERO SANCHEZ, A. M.* , Joiret, M., Seca, C., El Hachem, N., Valenti, G., Latini, S., Shostak, K., Geris, L., Li, P., Huang, G., Mazzucchelli, G., Baiwir, D., Desmet, C., Chariot, A., Georges, M., & Close, P. (2021). Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate. Nature Communications, 12 (1), 2170. doi:10.1038/s41467-021-22254-5
* These authors have contributed equally to this work.

Rosu, A., El Hachem, N., Rapino, F., Rouault-Pierre, K., Jorssen, J., SOMJA, J., Ramery, E., Thiry, M., Nguyen, L., Jacquemyn, M., Daelemans, D., Adams, C. M., Bonnet, D., Chariot, A., Close, P., Bureau, F., & Desmet, C. (2021). Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis. Journal of Experimental Medicine, 218 (3). doi:10.1084/jem.20200662

Joiret, M., Rapino, F., Close, P., & Geris, L. (05 September 2019). mRNA translation rate modeling with an extended TASEP incorporating tRNAs modifications [Poster presentation]. EMBO Workshop - Protein Synthesis and Translational Control, Heidelberg, Germany.

Lorent, J., Kusnadi, E. P., van Hoef, V., Rebello, R. J., Leibovitch, M., Ristau, J., Chen, S., Lawrence, M. G., Szkop, K. J., Samreen, B., Balanathan, P., Rapino, F., Close, P., Bukczynska, P., Scharmann, K., Takizawa, I., Risbridger, G. P., Selth, L. A., Leidel, S. A., ... Furic, L. (2019). Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression. EMBO Journal. doi:10.15252/embj.2018101323

Rapino, F. (2019). Uncovering the U34 tRNA modifying enzymes target proteome and its impact in human disease [Paper presentation]. International Cancer Conference.

Rapino, F. (2019). Codon-specific translation reprogramming promotes resistance to targeted therapy [Poster presentation]. RNA society meeting.

Rapino, F., & Close, P. (2018). Wobble uridine tRNA modification: a new vulnerability of refractory melanoma. Molecular and Cellular Oncology. doi:10.1080/23723556.2018.1513725

Rapino, F., Delaunay, S., Rambow, F., Zhou, Z., Tharun, L., De Tullio, P., Sin, O., Shostak, K., Schmitz, S., Piepers, J., Guesquière, B., Karim, L., Charloteaux, B., Jamart, D., Florin, A., Lambert, C., RORIVE, A., JERUSALEM, G., Leucci, E., ... Close, P. (28 June 2018). Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature, 558, 605-609. doi:10.1038/s41586-018-0243-7

Rapino, F. (02 February 2018). Translation reprogramming through U34 tRNA modification promotes resistance to targeted therapy [Paper presentation]. GIGA CANCER.

Rapino, F. (01 February 2017). Translation reprogramming through U34 tRNA modification promotes resistance to targeted therapy [Paper presentation]. GIGA DAY 2017.

Rapino, F., Zhou, Z., Delaunay, S., Chariot, A., & Close, P. (2017). tRNA modification: is cancer having a wobble? Trends in Cancer, 3, 249-252. doi:10.1016/j.trecan.2017.02.004

Delaunay, S., Rapino, F., Tharun, L., Zhou, Z., Heukamp, L., Termathe, M., Shostak, K., Klevernic, I., Florin, A., Desmecht, H., Desmet, C., Nguyen, L., Leiden, S. A., Willis, A. E., Buettner, R., Chariot, A., & Close, P. (October 2016). ELP3 links tRNA modification to IRES-dependent translation of LEF-1 to promote metastasis in breast cancer. Journal of Experimental Medicine, 213, 2503-2523. doi:10.1084/jem.20160397

Delaunay, S., Rapino, F., Tharun, L., Zhou, Z., Heukamp, L., Termathe, M., Shostak, K., Klevernic, I., Florin, A., Desmecht, H., Nguyen, L., Leidel, S., Willis, A., Chariot, A., & Close, P. (May 2016). tRNA modification: Elogator sustains Breast cancer metastasis [Paper presentation]. Invitation pour une présentation au Stem Cell Institute - Cambridge University, Cambridge, United Kingdom.

Delaunay, S., Rapino, F., Zhou, Z., Shostak, K., LADANG, A., Chariot, A., & Close, P. (25 January 2016). tRNA modification: Elogator promotes metastasis in breast cancer [Paper presentation]. GIGA-DAY 2016, Liège, Belgium.

Rapino, F. (25 January 2016). Dynamic regulation of U34 tRNA modification is required for oncogenic BRAF cell survival and resistance to therapies [Poster presentation]. 2016 GIGA DAY: SIGNAL TRASDUCTION PATHWAY IN HEALTH AND DISEASE.

Rapino, F. (03 December 2015). Dynamic regulation of U34 tRNA modification is required for oncogenic BRAF cell survival and resistance to therapies [Paper presentation]. Televie Day 2015, Belgium.

LADANG, A.* , Rapino, F.* , Heukamp, L., Tharun, L., Shostak, K., Hermand, D., Delaunay, S., Klevernic, I., Jiang, Z., Jacques, N., Jamart, D., Migeot, V., Florin, A., Göktuna, S., Malgrange, B., Samson, O., Nguyen, L., Buettner, R., Close, P., & Chariot, A. (16 November 2015). Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine. Journal of Experimental Medicine, 212 (12), 2057-75. doi:10.1084/jem.20142288
* These authors have contributed equally to this work.

Delaunay, S., Rapino, F., Zhou, Z., LADANG, A., Shostak, K., Chariot, A., & Close, P. (09 March 2015). Elongator: mcm5s2 modification fosters breast cancer metastasis [Paper presentation]. MRC toxicology meeting, Leicester, United Kingdom.

Delaunay, S., Rapino, F., Heukamp, L., LADANG, A., Jiang, Z., Nguyen, L., Buettner, R., Chariot, A., & Close, P. (March 2015). Elongator promotes breast cancer metastasis [Poster presentation]. EMBO meeting, Frontiers in stem cells, Heidelberg, Germany.

Rapino, F.* , Abhari, B.* , Jung, M., & Fulda, S. (2015). NIK is required for NF-κB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways. Cell Death and Disease. doi:10.1038/cddis.2014.584
* These authors have contributed equally to this work.

Rapino, F. (27 January 2015). tRAMES importance and modulation in cancer: an insight from the melanoma model [Poster presentation]. 2015 GIGA DAY SYMPOSIUM "CURRENT ADVANCES IN MEDICAL GENETICS AND GENOMICS, Belgium.

Corazzari, M., Rapino, F., Ciclosanti, F., Giglio, P., Antonioli, M., Conti, B., Fimia, G., Lovat, P., & Piacentini, M. (2014). Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma. Cell Death and Differentiation. doi:10.1038/cdd.2014.183

Rapino, F., Naumann, I., & Fulda, S. (2013). Bortezomib antagonizes microtubule-interfering drug-induced apoptosis by inhibiting G2/M transition and MCL-1 degradation. Cell Death and Disease. doi:10.1038/cddis.2013.440

Rapino, F. (2013). BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways [Doctoral thesis, J.W. Goethe University]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/191637

Rapino, F., Jung, M., & Fulda, S. (2013). BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways. Oncogene. doi:10.1038/onc.2013.110

Rapino, F. (06 September 2012). BAG3 is critically required for cell recovery of rhabdomyosarcoma cells after proteotoxic stress due to simultaneous inhibition of proteasomal degradation and selective autophagy [Poster presentation]. UCT International Science Day, Germany.

Rapino, F. (January 2012). Targeting selective aggresome autophagy enhances Bortezomib- induced cell [Poster presentation]. EACR conference “Cell death in Cancer”.