Publications of Liesbet Geris
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See detailAnalyzing the influence of driving physico-chemical characteristics in intra-oral bone regeneration using a predictive empirical model
Sadeghian Dehkord, Ehsan ULiege; Kerckhofs, Greet; Lambert, France et al

Scientific conference (2018, November 30)

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See detailDeveloping a predictive empirical model to optimize biomaterials characteristics for intra-oral bone regeneration
Sadeghian Dehkord, Ehsan ULiege; Kerckhofs, Greet; Lambert, France ULiege et al

Scientific conference (2018, September 11)

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See detailUnderstanding the interactions between Wnt and BMP signaling pathways in human Periosteum Derived Cells
Germain, Morgan ULiege; Bolander, Johanna; Geris, Liesbet ULiege

Conference (2018, September 07)

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See detailComputational modelling of the effect of growth factors on human mesenchymal stem cell proliferation in 3D porous scaffolds
Mehrian, Mohammad ULiege; Papantoniou, Ioannis; Lambrechts, Toon et al

in Proceedings of the Virtual Physiological Human conference (VPH), Zaragoza, Spain, 5-7 September 2018 (2018, September 05)

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See detailThe future is digital: In silico tissue engineering
Geris, Liesbet ULiege; Lambrechts, Toon; Carlier, Aurélie et al

in Current Opinion in Biomedical Engineering (2018), 6

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See detailMulti-objective optimization of cost-efficient neotissue growth inside 3D scaffolds using evolutionary algorithms
Mehrian, Mohammad ULiege; olofsson, Simon; Misener, Ruth et al

in Proceedings of the 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE) (2018, March 26)

Tissue engineering is a fast progressing domain where solutions are provided for organ failure or tissue damage. Computer models can facilitate the design of optimal production process conditions leading ... [more ▼]

Tissue engineering is a fast progressing domain where solutions are provided for organ failure or tissue damage. Computer models can facilitate the design of optimal production process conditions leading to robust and economically viable products. We developed a computational model describing the neotissue growth (cells + their ECM) inside 3D scaffolds in a perfusion bioreactor. Here we apply multi-objective optimization (MOO) to maximize neotissue growth whilst minimizing the cost coming from medium refreshment and associated labor. [less ▲]

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See detailComputational modelling of human mesenchymal stem cell proliferation and extra cellular matrix production in 3D porous scaffolds in a perfusion bioreactor
Mehrian, Mohammad ULiege; Papantoniou, Ioannis; Lambrechts, Toon et al

in Proceedings of the 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE) (2018, March 26)

3D porous scaffolds are frequently used in tissue engineering (TE) applications in combination with bioreactor systems because of their ability to induce reproducible culture conditions that can control ... [more ▼]

3D porous scaffolds are frequently used in tissue engineering (TE) applications in combination with bioreactor systems because of their ability to induce reproducible culture conditions that can control specific cell behavior such as proliferation and extracellular matrix (ECM) production. A computational model describing neotissue growth inside 3D scaffolds in a perfusion bioreactor was developed, with neotissue being considered the combination of cells and their extra cellular matrix. In the model, the speed of neotissue growth depends on the flow-induced shear stress, curvature and the local concentrations of oxygen, glucose and lactate. The goal of this study is to make a distinction between the cell and the ECM fraction within the neotissue in the model to allow for a more detailed validation and optimization of the process. [less ▲]

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See detailComputational Bone Tissue Engineering: Virtual Models for Living Implants
Geris, Liesbet ULiege

Conference (2018)

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See detailComputational modeling of tissue regeneration
Geris, Liesbet ULiege

Scientific conference (2018)

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See detailMultiphysics modeling for skeletal tissue engineering
Geris, Liesbet ULiege

Conference (2018)

Detailed reference viewed: 19 (1 ULiège)
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See detailIn silico clinical trials for pediatric orphan diseases.
Carlier, Aurélie; Vasilevich, A.; de Boer, J. et al

in Scientific Reports (2018), 8(1), 2465

To date poor treatment options are available for patients with congenital pseudarthrosis of the tibia (CPT), a pediatric orphan disease. In this study we have performed an in silico clinical trial on 200 ... [more ▼]

To date poor treatment options are available for patients with congenital pseudarthrosis of the tibia (CPT), a pediatric orphan disease. In this study we have performed an in silico clinical trial on 200 virtual subjects, generated from a previously established model of murine bone regeneration, to tackle the challenges associated with the small, pediatric patient population. Each virtual subject was simulated to receive no treatment and bone morphogenetic protein (BMP) treatment. We have shown that the degree of severity of CPT is significantly reduced with BMP treatment, although the effect is highly subject-specific. Using machine learning techniques we were also able to stratify the virtual subject population in adverse responders, non-responders, responders and asymptomatic. In summary, this study shows the potential of in silico medicine technologies as well as their implications for other orphan diseases. [less ▲]

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See detailVirtual physiological human 2016: Translating the virtual physiological human to the clinic
Hoekstra, A. G.; Bavel, E. V.; Siebes, M. et al

in Interface Focus (2018), 8(1),

[No abstract available]

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See detailBayesian Multi-Objective Optimisation with Mixed Analytical and Black-Box Functions: Application to Tissue Engineering
Olofsson, Simon; Mehrian, Mohammad ULiege; Calandra, Roberto et al

in IEEE Transactions on Biomedical Engineering (2018)

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See detailAdvancing osteochondral tissue engineering: bone morphogenetic protein, transforming growth factor, and fibroblast growth factor signaling drive ordered differentiation of periosteal cells resulting in stable cartilage and bone formation in vivo.
Mendes, L. F.; Katagiri, H.; Tam, W. L. et al

in Stem Cell Research and Therapy (2018), 9(1), 42

BACKGROUND: Chondrogenic mesenchymal stem cells (MSCs) have not yet been used to address the clinical demands of large osteochondral joint surface defects. In this study, self-assembling tissue ... [more ▼]

BACKGROUND: Chondrogenic mesenchymal stem cells (MSCs) have not yet been used to address the clinical demands of large osteochondral joint surface defects. In this study, self-assembling tissue intermediates (TIs) derived from human periosteum-derived stem/progenitor cells (hPDCs) were generated and validated for stable cartilage formation in vivo using two different animal models. METHODS: hPDCs were aggregated and cultured in the presence of a novel growth factor (GF) cocktail comprising of transforming growth factor (TGF)-beta1, bone morphogenetic protein (BMP)2, growth differentiation factor (GDF)5, BMP6, and fibroblast growth factor (FGF)2. Quantitative polymerase chain reaction (PCR) and immunohistochemistry were used to study in vitro differentiation. Aggregates were then implanted ectopically in nude mice and orthotopically in critical-size osteochondral defects in nude rats and evaluated by microcomputed tomography (microCT) and immunohistochemistry. RESULTS: Gene expression analysis after 28 days of in vitro culture revealed the expression of early and late chondrogenic markers and a significant upregulation of NOGGIN as compared to human articular chondrocytes (hACs). Histological examination revealed a bilayered structure comprising of chondrocytes at different stages of maturity. Ectopically, TIs generated both bone and mineralized cartilage at 8 weeks after implantation. Osteochondral defects treated with TIs displayed glycosaminoglycan (GAG) production, type-II collagen, and lubricin expression. Immunostaining for human nuclei protein suggested that hPDCs contributed to both subchondral bone and articular cartilage repair. CONCLUSION: Our data indicate that in vitro derived osteochondral-like tissues can be generated from hPDCs, which are capable of producing bone and cartilage ectopically and behave orthotopically as osteochondral units. [less ▲]

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See detailIn silico methods - Computational alternatives to animal testing.
Lang, Annemarie; Volkamer, Andrea; Behm, Laura et al

in ALTEX: Alternatives to Animal Experimentation (2018), 35(1), 124-126

Detailed reference viewed: 33 (1 ULiège)