Publications of Christine Bastin
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See detailFeeling the ease: how the use of oral motor fluency changes in amnesia
Geurten, Marie ULiege; Bastin, Christine ULiege; Willems, Sylvie ULiege

in Journal of Neuropsychology (in press)

The present study examined the evolution observed in amnesic patients’ use of motor fluency when making recognition memory decisions. In this experiment, 9 patients with amnesia and 18 matched controls ... [more ▼]

The present study examined the evolution observed in amnesic patients’ use of motor fluency when making recognition memory decisions. In this experiment, 9 patients with amnesia and 18 matched controls were presented with two recognition memory tasks composed of 3 types of items: (a) natural words, (b) nonwords difficult to pronounce, and (c) nonwords easy to pronounce, the latter having been shown to be processed in a surprisingly fluent manner as long as participants can articulate them at a subvocal level (i.e., oral motor fluency). Our results provide evidence that the motor-movement manipulation was successful to induce a fluency effect. More specifically, data revealed that both amnesic patients and control participants showed a pattern of response consistent with the use of fluency as a cue to memory for studied items. However, only control participants relied on fluency to increase their rate of “yes” responses for unstudied items. These results suggest that patients with amnesia set a more conservative response criterion before relying on oral motor fluency, showing a pattern consistent with the idea that fluency is only used as a cue to memory when it exceeds a certain threshold. These findings are discussed in terms of adaptative metacognition strategies implemented by amnesic patients to reduce fluency-based memory errors as well as in terms of the variations that seem to occur in these strategies depending on the type of fluency that is experienced. [less ▲]

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See detailRepeatability of ultra-high-resolution Multi-Parametric Mapping across five 7T sites
Sherif, Siya ULiege; Aghaeifar, Ali; pine., Kerrin et al

Conference (2022)

Detailed reference viewed: 44 (2 ULiège)
See detailTimely sleep coupling: phase locked slow wave - spindle pairing is linked to AD neuropathology and forecasts cognitive decline
Chylinski, Daphné ULiege; Van Egroo, Maxime; Narbutas, Justinas ULiege et al

Conference (2021, November 19)

Alteration of sleep quality is a hallmark of the ageing process. The fine-tuned coalescence of elements of sleep microstructure seems to play a pivotal role in cognitive trajectories in ageing. This may ... [more ▼]

Alteration of sleep quality is a hallmark of the ageing process. The fine-tuned coalescence of elements of sleep microstructure seems to play a pivotal role in cognitive trajectories in ageing. This may be of prime clinical importance as a bidirectional detrimental relationship between sleep quality and Alzheimer’s disease (AD) neuropathology emerges in the literature and holds promise for novel sleep related interventions. However, sleep is not yet established as a true risk factor for AD, most likely because the understanding of its core associations with AD neuropathology remains insufficient. In this context, we focused on the timely coupling of two key graphoelements of Non-Rapid Eye Movement (NREM) sleep that is slow waves and spindles, and their associations with AD neuropathology and cognition. We show, in a detailed large dataset (N=100; 68 woman) of undisturbed sleep recorded in late middle-aged healthy individuals (50 to 70y; 60 +- 5), that the precise coupling of sleep spindles with a specific category of sleep slow waves, those deemed most important for memory consolidation, is associated to lower medial prefrontal cortex PET-scan β-Amyloid burden, a landmark of AD neuropathology (F1,96=6.2, p=0.014). Cruder aspects of sleep macrostructure and sleep intensity were, however, not significantly linked to β-Amyloid burden in this relatively young sample with low β-Amyloid deposit. We further show that this specific coupling is predictive of a lower memory decline, assessed over 2 years using a task highly sensitive to the first signs of memory impairment (F1,54=4.67, p=0.035). These findings unravel early links between sleep, AD-related and cognitive trajectories in ageing and suggest that altered coupling of sleep microstructure elements key to its functions could constitute the first association with AD neuropathology and that less refined measures of sleep macrostructure or sleep intensity may only be significantly associated to AD neuropathology later in life, when β-amyloid burden is higher. Sleep microstructure integrity could therefore constitute a potential indicator of a less successful ageing trajectory. [less ▲]

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See detailIn vivo exploration of synaptic projections in frontotemporal dementia.
Salmon, Eric ULiege; Bahri, Mohamed Ali ULiege; Plenevaux, Alain ULiege et al

in Scientific Reports (2021)

The purpose of this exploratory research is to provide data on synaptopathy in the behavioral variant of frontotemporal dementia (bvFTD). Twelve patients with probable bvFTD were compared to 12 control ... [more ▼]

The purpose of this exploratory research is to provide data on synaptopathy in the behavioral variant of frontotemporal dementia (bvFTD). Twelve patients with probable bvFTD were compared to 12 control participants and 12 patients with Alzheimer’s disease (AD). Loss of synaptic projections was assessed with ­[18F]UCBH-PET. Total distribution volume was obtained with Logan method using carotid artery derived input function. Neuroimages were analyzed with SPM12. Verbal fluency, episodic memory and awareness of cognitive impairment were equally impaired in patients groups. Compared to controls, ­[18F]UCBH uptake tended to decrease in the right anterior parahippocampal gyrus of bvFTD patients. Loss of synaptic projections was observed in the right hippocampus of AD participants, but there was no significant difference in ­[18F]UCBH brain uptake between patients groups. Anosognosia for clinical disorder was correlated with synaptic density in the caudate nucleus and the anteromedial prefrontal cortex. This study suggests that synaptopathy in bvFTD targets the temporal social brain and self-referential processes. [less ▲]

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See detailJacoby-Whitehouse illusion from taxonomic and thematic associations in Alzheimer's disease
Demonty, Manon ULiege; Invernizzi, Sandra; Delhaye, Emma ULiege et al

Poster (2021, May 28)

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See detailEpisodic memory and the importance of attribution processes to assess the retrieved memory contents
Bastin, Christine ULiege

Conference (2021, May 21)

The Integrative Memory model describes the core mechanisms leading to recollection (i.e., to recall qualitative details about a past event) and familiarity (i.e., to identify some event as previously ... [more ▼]

The Integrative Memory model describes the core mechanisms leading to recollection (i.e., to recall qualitative details about a past event) and familiarity (i.e., to identify some event as previously encountered) as specific computational operations applying to specific types of representation. Critically, the model distinguishes them from the subjective experiences of remembering and knowing that only emerge following additional attribution operations. I will present evidence supporting several principles from the Integrative Memory model, notably data indicating that one can report a highly vivid experience of memory despite recalling only a few episodic details. I will also present some recent data moving towards inter-personal mechanisms underlying the sharing of memories. [less ▲]

Detailed reference viewed: 43 (2 ULiège)
See detailSubjective remembering experience in aging: Disconnection between vividness ratings and objective recollection
Bastin, Christine ULiege

Conference (2021, May 17)

Recollection allows humans to retrieve specific details about past events (objective recollection) and to have the subjective feeling of re-experiencing these events (subjective recollection). Healthy ... [more ▼]

Recollection allows humans to retrieve specific details about past events (objective recollection) and to have the subjective feeling of re-experiencing these events (subjective recollection). Healthy aging affects episodic memory, with consensual difficulty in objective recollection. Notably, older adults recall fewer episodic details than young adults when remembering past episodes. Some studies reported however that older adults judge their memories as being very vivid or claim high confidence in their memory. This would indicate intact subjective recollection. Our research aims at demonstrating whether there is an objective-subjective disconnection in recollection during aging. Using a lab-based and a lifelogging approach, we performed multilevel regression models to assess whether objective recollection performance predicts subjective recollection experience for the same trials in young and older participants. We observed that older adults’ ratings of having vivid memories for past events do not rely as much on the actual number of episodic details they retrieve as in young participants. We conducted also a neuroimaging (fMRI) study to examine the neural basis of highly vivid memories in young and older participants. This work can inform us about how humans generate the subjective experience of remembering. [less ▲]

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See detailL'impact du confinement dû à la pandémie de COVID-19 sur la fatigue
Requier, Florence ULiege; Guillemin, Camille ULiege; Reyt, Mathilde ULiege et al

Conference (2021, May 10)

La pandémie de COVID-19 et le confinement instauré en mars 2020 ont eu des répercussions sur notre fonctionnement quotidien et notre qualité de vie. Certaines études se sont intéressées à leurs impacts ... [more ▼]

La pandémie de COVID-19 et le confinement instauré en mars 2020 ont eu des répercussions sur notre fonctionnement quotidien et notre qualité de vie. Certaines études se sont intéressées à leurs impacts sur des variables plutôt affectives, cependant, l'impact de ces événements sur la fatigue mentale et physique de la population a été peu étudié. L’objectif de notre étude est de déterminer quels facteurs, liés à la nouvelle situation, ont influencé la fatigue, d’une part, chez les travailleurs et, d’autre part, chez les personnes retraitées. Un questionnaire en ligne a été développé et diffusé pendant le confinement auprès d’une population européenne francophone. Des modèles généralisés mixtes ont été utilisés, séparément, sur les données de 430 travailleurs (Âge : 40.43 ± 12.16, 357 femmes) et de 124 personnes retraitées (Âge : 68.86 ± 6.13, 66 femmes). Nous avons constaté une augmentation de la fatigue physique et de la fatigue mentale perçues et nous avons observé si cette augmentation était liée à certaines variables telles que les données démographiques et affectives, l’évolution de l’environnement professionnel, l’évolution des occupations quotidiennes, les préoccupations liées au COVID, les changements relatifs au sommeil et l’évolution du degré de charge mentale (p<.05). Chez les travailleurs, nous avons trouvé des associations positives entre la fatigue physique et l’anxiété, l’effort au travail, les préoccupations liées au COVID, le dysfonctionnement diurne et la charge mentale. La fatigue physique a des relations négatives avec l’âge, les activités physiques, le degré de satisfaction envers les occupations, ainsi que la qualité et l’efficacité de sommeil. La fatigue mentale est, quant à elle, associée positivement avec l’anxiété, l’effort au travail, le télétravail, les préoccupations liées au COVID, les troubles du sommeil, le dysfonctionnement diurne et la charge mentale. Des relations négatives sont mises en évidence concernant la fatigue mentale et l’occupation au travail, l’utilisation de somnifères et le degré de satisfaction envers les occupations. Chez les personnes retraitées, nous avons observé des relations positives entre la fatigue physique et le niveau d’anxiété ainsi que les préoccupations liées au COVID-19 et une relation négative avec le degré de satisfaction envers les occupations L’augmentation de fatigue est associée à la modification d’une série d’activités quotidiennes induite par la situation sanitaire. Des programmes d’action ciblés sur ces comportements ou ces états modifiables laissent entrevoir des pistes d’intervention adaptées à cette situation. L’impact à long terme et les éventuelles stratégies mises en place par la population, suite à cette situation, restent à être investigués. [less ▲]

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See detailImpaired explicit self-awareness but preserved behavioral regulation in patients with Alzheimer Disease
Geurten, Marie ULiege; Salmon, Eric ULiege; Bastin, Christine ULiege

in Aging and Mental Health (2021), 25(1), 142-148

Objectives: Impairments of metacognitive skills represent a critical symptom in Alzheimer Disease (AD) because it frequently results in a lack of self-awareness. However, recent findings suggest that ... [more ▼]

Objectives: Impairments of metacognitive skills represent a critical symptom in Alzheimer Disease (AD) because it frequently results in a lack of self-awareness. However, recent findings suggest that, despite an inability to explicitly estimate their own cognitive functioning, patients might demonstrate some implicit recognition of difficulties. In this study, we tested whether a behavioral dissociation between explicit and implicit measures of metacognition can be found in both healthy older controls (n = 20) and AD patients (n = 20). Methods: Our two groups of participants (AD vs. Controls) were asked to complete a forced-choice perceptual identification test and to explicitly rate their confidence in each decision (i.e., explicit measure of metacognition). Moreover, they also had the opportunity to ask for a cue to help them decide if their response was correct (i.e., implicit measure of metacognition). Results: Data revealed that all participants asked for a cue more often after an incorrect response than after a correct response in the forced-choice identification test, indicating a good ability to implicitly introspect on the results of their cognitive operations. On the contrary, only healthy participants displayed metacognitive sensitivity when making explicit confidence judgments. Conclusion: Our findings suggest that implicit metacognition may be less affected than explicit metacognition in Alzheimer’s disease. [less ▲]

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See detailShared event memory in aging: Across-participants similarity of vividness judgements decreases with age
Folville, Adrien ULiege; Vandeleene, Nora ULiege; Bastin, Christine ULiege

in Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition (2021)

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See detailShared event-memory for a public event in young and older adults
Cheriet, Nawël ULiege; Folville, Adrien ULiege; Bastin, Christine ULiege

in Applied Cognitive Psychology (2021), 35

This study examined the extent to which individuals can share similar memory representations of a public event and potential age-related differences in memory similarity. Fifty-three young and 59 older ... [more ▼]

This study examined the extent to which individuals can share similar memory representations of a public event and potential age-related differences in memory similarity. Fifty-three young and 59 older Belgian participants completed an online survey, where they recalled the deadly collapse of a bridge in a neighboring country 7 months ago. Results showed no age-related differences in the number of details remembered or the amount of overlap of details within an age group. However, older participants mentioned the consequences of the incident more frequently than younger participants. These findings suggest that individuals who remember the same event can share common memory details and that across-participants memory similarity for a public event remains spared in normal aging. [less ▲]

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See detailBoosting familiarity-based memory decisions in Alzheimer’s Disease: The importance of metacognition
Geurten, Marie ULiege; Salmon, Eric ULiege; Willems, Sylvie ULiege et al

in Journal of the International Neuropsychological Society (2021), 27

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See detailFrontal hypometabolism in neurocognitive disorder with behavioral disturbance
Bastin, Christine ULiege; Bahri, Mohamed Ali ULiege; BERNARD, Claire ULiege et al

in The Journal of Nuclear Medicine (2021)

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See detailI remember it like it was yesterday: Age-related differences in the subjective experience of remembering
Folville, Adrien ULiege; Simons, Jon S.; D'Argembeau, Arnaud ULiege et al

in Psychonomic Bulletin and Review (2021)

It has been frequently described that older adults subjectively report the vividness of their memories as being as high, or even higher, than young adults, despite poorer objective memory performance ... [more ▼]

It has been frequently described that older adults subjectively report the vividness of their memories as being as high, or even higher, than young adults, despite poorer objective memory performance. Here, we review studies that examined age-related differences in the subjective experience of memory vividness. By examining vividness calibration and resolution, studies using different types of approaches converge to suggest that older adults overestimate the intensity of their vividness ratings relative to young adults, and that they rely on retrieved memory details to a lesser extent to judge vividness. We discuss potential mechanisms underlying these observations. Inflation of memory vividness with regard to the richness of memory content may stem from age-differences in vividness criterion or scale interpretation and psycho-social factors. The reduced reliance on episodic memory details in older adults may stem from age-related differences in how they monitor these details to make their vividness ratings. Considered together, these findings emphasize the importance of examining age-differences in memory vividness using different analytical methods and they provide valuable evidence that the subjective experience of remembering is more than the reactivation of memory content. In this vein, we recommend that future studies explore the links between memory vividness and other subjective memory scales (e.g., ratings of details or memory confidence) in healthy aging and/or other populations, as it could be used as a window to better characterize the cognitive processes that underpin the subjective assessment of the quality of recollected events. [less ▲]

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See detailFamiliarity in Mild Cognitive Impairment as a function of patients’ clinical outcome four years later
Bastin, Christine ULiege; Bahri, Mohamed Ali ULiege; Giacomelli, Fabrice ULiege et al

in Alzheimer Disease and Associated Disorders (2021), 35(4), 321-326

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See detailEfficacy of cognitive rehabilitation versus usual treatment at home in patients with early stages of Alzheimer Disease
KURTH, Sophie ULiege; WOJTASIK, Vinciane ULiege; LEKEU, Françoise ULiege et al

in Journal of Geriatric Psychiatry and Neurology (2021), 34(3), 209-215

Detailed reference viewed: 33 (1 ULiège)