Publications of Jean-François Focant
Bookmark and Share    
Full Text
See detailInsights into olefin oligomerization products based on GC×GC-PI-TOFMS
Zou, Yun ULiege; Stefanuto, Pierre-Hugues ULiege; Maimone, Mariarosa et al

Conference (2021, June)

Detailed reference viewed: 27 (8 ULiège)
Full Text
See detailRecent Applications of Volatolomics
Focant, Jean-François ULiege; Stefanuto, Pierre-Hugues ULiege

Scientific conference (2021, May)

Detailed reference viewed: 28 (1 ULiège)
Full Text
See detailRecent Applications of Volatolomics
Stefanuto, Pierre-Hugues ULiege; Dubois, Lena ULiege; Zanella, Delphine ULiege et al

Scientific conference (2021, May)

Detailed reference viewed: 40 (3 ULiège)
Full Text
See detailGC×GC-TOFMS for boar taint volatolomics
Dubois, Lena ULiege; Delhaye, Myriam; Mayeres, Patrick et al

Poster (2021, January)

Detailed reference viewed: 45 (6 ULiège)
Full Text
See detailAsthma phenotyping using exhaled breath analysis and full-scan SIFT-MS data
Stefanuto, Pierre-Hugues ULiege; Zanella, Delphine ULiege; Vercammen, Joeri et al

Conference (2021)

Detailed reference viewed: 24 (1 ULiège)
Full Text
See detailAdvanced mono‐ and multi‐dimensional gas chromatography–mass spectrometry techniques for oxygen‐containing compound characterization in biomass and biofuel samples
Beccaria, Marco ULiege; Anna Luiza, Mendes Siqueira; Adrien, Maniquet et al

in Journal of Separation Science (2021), 44

A wide variety of biomass, from triglycerides to lignocellulosic‐based feedstock, are among promising candidates to possibly fulfill requirements as a substitute for crude oils as primary sources of ... [more ▼]

A wide variety of biomass, from triglycerides to lignocellulosic‐based feedstock, are among promising candidates to possibly fulfill requirements as a substitute for crude oils as primary sources of chemical energy feedstock. During the feedstock processing carried out to increase the H:C ratio of the products, heteroatom‐containing compounds can promote corrosions, thus limiting and/or deactivating catalytic processes needed to transform the biomass into fuel. The use of advanced gas chromatography techniques, in particular multi‐dimensional gas chromatography, both heart‐cutting and comprehensive coupled to mass spectrometry, has been widely exploited in the field of petroleomics over the past 30 years and has also been successfully applied to the characterization of volatile and semi‐volatile compounds during the processing of biomass feedstock. This review intends to describe advanced gas chromatography–mass spectrometry‐based techniques, mainly focusing in the period 2011–early 2020. Particular emphasis has been devoted to the multi‐dimensional gas chromatography–mass spectrometry techniques, for the isolation and characterization of the oxygen‐containing compounds in biomass feedstock. Within this context, the most recent advances to sample preparation, derivatization, as well as gas chromatography instrumentation, mass spectrometry ionization, identification, and data handling in the biomass industry, are described. [less ▲]

Detailed reference viewed: 32 (6 ULiège)
Full Text
See detailThe Ultimate Untargeted Technique
Stefanuto, Pierre-Hugues ULiege; Zanella, Delphine ULiege; Focant, Jean-François ULiege

in The Analytical Scientist (2020), 90

Detailed reference viewed: 35 (3 ULiège)
Full Text
See detailInvestigating aroma diversity combining purge‐and‐trap, comprehensive two‐dimensional gas chromatography, and mass spectrometry
Franchina, Flavio ULiege; Zanella, Delphine ULiege; Lazzari, Eliane ULiege et al

in Journal of Separation Science (2020), 43

Headspace gas chromatography is frequently used for aroma profiling thanks to its ability to naturally exploit the volatility of aroma compounds, and also to provide chemical information on sample ... [more ▼]

Headspace gas chromatography is frequently used for aroma profiling thanks to its ability to naturally exploit the volatility of aroma compounds, and also to provide chemical information on sample composition. Its main advantages rely on simplicity, no use of solvent, amenability to automation, and the cleanliness of the extract. In the present contribution, the most effective sampling (dynamic extraction), separation (multidimensional gas chromatography), and detection (mass spectrometry) techniques for untargeted analysis are exploited in combination, showing their potential in unraveling aroma profiles in fruit beers. To complete the overall analytical process, a neat workflow for data analysis is discussed and used for the successful characterization and identification of five different beer flavors (berries, cherry, banana, apple, and peach). From the technical viewpoint, the coupling of purge-andtrap, comprehensive two-dimensional gas chromatography, and mass spectrometry makes the global methodology unique, and it is for the first time discussed. A (low- )flow modulation approach allowed for the full transfer into the second dimension with mass-spectrometry compatible flow (< 7 mL/min), avoiding the need of splitting before detection and making the overall method sensitive (1.2–5.2-fold higher signal to noise ratio compared to unmodulated gas chromatography conditions) and selective. [less ▲]

Detailed reference viewed: 59 (20 ULiège)
Full Text
See detailMultimodal Approaches for Untargeted Screening for Medical Applications of the Human Volatilome
Stefanuto, Pierre-Hugues ULiege; Zanella, Delphine ULiege; SCHLEICH, FLorence ULiege et al

Conference (2020, March)

The ballistic rise of analytical technologies has opened a large playground for all type of untargeted “omics” screening. In that trend, there is a rising interest for the characterization of the human ... [more ▼]

The ballistic rise of analytical technologies has opened a large playground for all type of untargeted “omics” screening. In that trend, there is a rising interest for the characterization of the human volatilome. Indeed, the characterization and the understanding of the volatile organic compounds (VOCs) production in different ex vivo matrices could open the route for improved diagnosis approach and new treatment. In the field of volatilomics, separation science based on multidimensional methods such as comprehensive two-dimensional gas chromatography (GC×GC) appeared as one of the methods of choice for the characterization complex VOC mixtures. At the price of high cost equipment and limited adaptability to routine medical usage, GC×GC offers the possibility to almost completely characterize a sample. For large scale screening, direct introduction instruments such as selected ion flow tube mass spectrometry (SIFT-MS) offered the capacity to perform both targeted and untargeted analyses within a few minutes. SIFT-MS can generate compositional patterns from direct sample introduction at the same time than other routine medical actions. These two orthogonal approaches for pathology screening should ideally conduct to identical sample classifications but have never been directly compared over an identical set of patients. In order to evaluate their complementarity, breath from 50 well-characterized asthmatic patients were analyzed by both approaches. Breath samples were collected using Tedlar bags. For GC×GC-HRTOFMS analyses, the bags were transferred onto thermal desorption tubes prior to injection. For SIFT-MS, the bags were directly emptied into the instrument. Next, data were analyzed using identical processing workflow. We observed that both approaches offered similar classification capacities. GC×GC-HRTOFMS allowed identifying the putative markers for comparison with previous studies and metabolic interpretation, while SIFT-MS offered a faster screening capacity. [less ▲]

Detailed reference viewed: 80 (10 ULiège)
Full Text
See detailIn vitro characterization of lung inflammation mechanisms
Focant, Jean-François ULiege; Zanella, Delphine ULiege; HENKET, Monique ULiege et al

Conference (2020, January)

Detailed reference viewed: 37 (7 ULiège)