Publications and communications of Docquier, Jean-Denis

Verdirosa, F., Gavara, L., Sevaille, L., Tassone, G., Corsica, G., Legru, A., Feller, G., Chelini, G., Mercuri, P., Tanfoni, S., Sannio, F., Benvenuti, M., Cerboni, G., De Luca, F., Bouajila, E., Hoang, Y. V., Licznar-Fajardo, P., Galleni, M., Pozzi, C., & Hernandez, J.-F. (January 2022). 1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-β-Lactamase Inhibitors. ChemMedChem, e202100699. doi:10.1002/cmdc.202100699

Gavara, L., Legru, A., Verdirosa, F., Sevaille, L., Nauton, L., Corsica, G., Mercuri, P., Sannio, F., Feller, G., Coulon, R., De Luca, F., Cerboni, G., Tanfoni, S., Chelini, G., Galleni, M., Docquier, J.-D., & Hernandez, J.-F. (2021). 4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors. Bioorganic Chemistry, 113. doi:10.1016/j.bioorg.2021.105024

Kwapien, K., Gavara, L., Docquier, J.-D., Berthomieu, D., Hernandez, J.-F., & Gresh, N. (2021). Intermolecular interactions of the extended recognition site of VIM-2 metallo-β-lactamase with 1,2,4-triazole-3-thione inhibitors. Validations of a polarizable molecular mechanics potential by ab initio QC. Journal of Computational Chemistry, 42 (2), 86-106. doi:10.1002/jcc.26437

Legru, A., Verdirosa, F., Hernandez, J.-F., Tassone, G., Sannio, F., Benvenuti, M., Conde, P.-A., Bossis, G., Thomas, C. A., Crowder, M. W., Dillenberger, M., Becker, K., Pozzi, C., Mangani, S., Docquier, J.-D., & Gavara, L. (2021). 1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity. European Journal of Medicinal Chemistry, 226, 113873. doi:10.1016/j.ejmech.2021.113873

Martin, M. J., Corey, B. W., Sannio, F., Hall, L. R., MacDonald, U., Jones, B. T., Mills, E. G., Harless, C., Stam, J., Maybank, R., Kwak, Y., Schaufler, K., Becker, K., Hübner, N.-O., Cresti, S., Tordini, G., Valassina, M., Cusi, M. G., Bennett, J. W., & Docquier, J.-D. (2021). Anatomy of an extensively drug-resistant Klebsiella pneumoniae outbreak in Tuscany, Italy. Proceedings of the National Academy of Sciences, 118 (48 e2110227118). doi:10.1073/pnas.2110227118

Davies, D. T., Leiris, S., Zalacain, M., Sprynski, N., Castandet, J., Bousquet, J., Lozano, C., Llanos, A., Alibaud, L., Vasa, S., Pattipati, R., Valige, R., Kummari, B., Pothukanuri, S., De Piano, C., Morrissey, I., Holden, K., Warn, P., Marcoccia, F., & Everett, M. (December 2020). Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii. Journal of Medicinal Chemistry, 63 (24), 15802–15820. doi:10.1021/acs.jmedchem.0c01535

Marcoccia, F., Sannio, F., De Luca, F., Benvenuti, M., Pozzi, C., Mangani, S., Sprynski, N., Leiris, S., Everett, M., & Docquier, J.-D. (April 2020). Interaction of the new diazabicyclooctanone (DBO) β-lactamase inhibitor ANT3310 with clinically relevant β-lactamases: a biochemical and structural study. Poster session presented at 30th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Paris, France.

Bassini, E., Gazzotti, S., Sannio, F., Presti, L. L., Sgrignani, J., Docquier, J.-D., Grazioso, G., & Silvani, A. (2020). Isonitrile-based multicomponent synthesis of β-amino boronic acids as β-lactamase inhibitors. Antibiotics, 9 (5), 1-21. doi:10.3390/antibiotics9050249

Davies, D. T., Leiris, S., Sprynski, N., Castandet, J., Lozano, C., Bousquet, J., Zalacain, M., Vasa, S., Dasari, P. K., Pattipati, R., Vempala, N., Gujjewar, S., Godi, S., Jallala, R., Sathyap, R. R., Darshanoju, N. A., Ravu, V. R., Juventhala, R. R., Pottabathini, N., & Everett, M. (2020). ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae. ACS Infectious Diseases, 6 (9), 2419-2430. doi:10.1021/acsinfecdis.0c00207

Gavara, L., Sevaille, L., De Luca, F., Mercuri, P., Bebrone, C., Feller, G., Legru, A., Cerboni, G., Tanfoni, S., Baud, D., Cutolo, G., Bestgen, B., Chelini, G., Verdirosa, F., Sannio, F., Pozzi, C., Benvenuti, M., Kwapien, K., Fischer, M., & Hernandez, J.-F. (2020). 4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-beta-lactamase inhibitors. European Journal of Medicinal Chemistry, 208, 112720. doi:10.1016/j.ejmech.2020.112720

Gavara, L., Verdirosa, F., Legru, A., Mercuri, P., Nauton, L., Sevaille, L., Feller, G., Berthomieu, D., Sannio, F., Marcoccia, F., Tanfoni, S., De Luca, F., Gresh, N., Galleni, M., Docquier, J.-D., & Hernandez, J.-F. (2020). 4-(N-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-Beta-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition. Biomolecules, 10 (8), 1094. doi:10.3390/biom10081094

Hamrick, J. C., Docquier, J.-D., Uehara, T., Myers, C. L., Six, D. A., Chatwin, C. L., John, K. J., Vernacchio, S. F., Cusick, S. M., Trout, R. E. L., Pozzi, C., De Luca, F., Benvenuti, M., Mangani, S., Liu, B., Jackson, R. W., Moeck, G., Xerri, L., Burns, C. J., & Daigle, D. M. (2020). VNRX-5133 (Taniborbactam), a broad-spectrum inhibitor of serine- And metallo-β-lactamases, restores activity of cefepime in enterobacterales and Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 64 (3). doi:10.1128/AAC.01963-19

Liu, B., Trout, R. E. L., Chu, G.-H., Mcgarry, D., Jackson, R. W., Hamrick, J. C., Daigle, D. M., Cusick, S. M., Pozzi, C., De Luca, F., Benvenuti, M., Mangani, S., Docquier, J.-D., Weiss, W. J., Pevear, D. C., Xerri, L., & Burns, C. J. (2020). Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. Journal of Medicinal Chemistry, 63 (6), 2789-2801. doi:10.1021/acs.jmedchem.9b01518

Mack, A. R., Barnes, M. D., Taracila, M. A., Hujer, A. M., Hujer, K. M., Cabot, G., Feldgarden, M., Haft, D. H., Klimke, W., Van Den Akker, F., Vila, A. J., Smania, A., Haider, S., Papp-Wallace, K. M., Bradford, P. A., Rossolini, G. M., Docquier, J.-D., Frère, J.-M., Galleni, M., & Bonomo, R. A. (2020). A standard numbering scheme for class C β-lactamases. Antimicrobial Agents and Chemotherapy, 64 (3). doi:10.1128/AAC.01841-19

Mugnaini, C., Sannio, F., Brizzi, A., Del Prete, R., Simone, T., Ferraro, T., De Luca, F., Corelli, F., & Docquier, J.-D. (2020). Screen of Unfocused Libraries Identified Compounds with Direct or Synergistic Antibacterial Activity. ACS Medicinal Chemistry Letters, 11 (5), 899-905. doi:10.1021/acsmedchemlett.9b00674

Piccirilli, A., Brisdelli, F., Docquier, J.-D., Aschi, M., Cherubini, S., De Luca, F., Matagne, A., Amicosante, G., & Perilli, M. (2020). Amino acid replacement at position 228 induces fluctuation in the Ω-loop of KPC-3 and reduces the affinity against oxyimino cephalosporins: Kinetic and molecular dynamics studies. Catalysts, 10 (12), 1-14. doi:10.3390/catal10121474

Spyrakis, F., Santucci, M., Maso, L., Cross, S., Gianquinto, E., Sannio, F., Verdirosa, F., De Luca, F., Docquier, J.-D., Cendron, L., Tondi, D., Venturelli, A., Cruciani, G., & Costi, M. P. (2020). Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases. Scientific Reports, 10 (1). doi:10.1038/s41598-020-69431-y

Leiris, S., Coelho, A., Castandet, J., Bayet, M., Lozano, C., Bougnon, J., Bousquet, J., Everett, M., Lemonnier, M., Sprynski, N., Zalacain, M., Pallin, T. D., Cramp, M. C., Jennings, N., Raphy, G., Jones, M. W., Pattipati, R., Shankar, B., Sivasubrahmanyam, R., & Davies, D. T. (2019). SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model. ACS Infectious Diseases, 5 (1), 131-140. doi:10.1021/acsinfecdis.8b00246

Cecchini, T., Yoon, E.-J., Charretier, Y., Bardet, C., Beaulieu, C., Lacoux, X., Docquier, J.-D., Lemoine, J., Courvalin, P., Grillot-Courvalin, C., & Charrier, J.-P. (2018). Deciphering multifactorial resistance phenotypes in acinetobacter baumannii by genomics and targeted label-free proteomics. Molecular and Cellular Proteomics, 17 (3), 442-456. doi:10.1074/mcp.RA117.000107

Di Pisa, F., Pozzi, C., Benvenuti, M., Docquier, J.-D., De Luca, F., & Mangani, S. (2018). Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design. Inorganica Chimica Acta, 470, 331-341. doi:10.1016/j.ica.2017.07.030

Docquier, J.-D., & Mangani, S. (2018). An update on β-lactamase inhibitor discovery and development. Drug Resistance Updates, 36, 13-29. doi:10.1016/j.drup.2017.11.002

Everett, M., Sprynski, N., Coelho, A., Castandet, J., Bayet, M., Bougnon, J., Lozano, C., Davies, D. T., Leiris, S., Zalacain, M., Morrissey, I., Magnet, S., Holden, K., Warn, P., De Luca, F., Docquier, J.-D., & Lemonniera, M. (2018). Discovery of a novel metallo-beta-lactamase inhibitor that potentiates meropenem activity against carbapenem-resistant enterobacteriaceae. Antimicrobial Agents and Chemotherapy, 62 (5). doi:10.1128/AAC.00074-18

Iannelli, F., Santoro, F., Santagati, M., Docquier, J.-D., Lazzeri, E., Pastore, G., Cassone, M., Oggioni, M. R., Rossolini, G. M., Stefani, S., & Pozzi, G. (2018). Type M resistance to macrolides is due to a two-gene efflux transport system of the ATP-binding cassette (ABC) superfamily. Frontiers in Microbiology, 9, 1-9. doi:10.3389/fmicb.2018.01670

Pasero, C., D'Agostino, I., De Luca, F., Zamperini, C., Deodato, D., Truglio, G. I., Sannio, F., Del Prete, R., Ferraro, T., Visaggio, D., Mancini, A., Guglielmi, M. B., Visca, P., Docquier, J.-D., & Botta, M. (2018). Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization. Journal of Medicinal Chemistry, 61 (20), 9162-9176. doi:10.1021/acs.jmedchem.8b00619

Pozzi, C., Di Pisa, F., De Luca, F., Benvenuti, M., Docquier, J.-D., & Mangani, S. (2018). Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam. ChemMedChem, 13 (14), 1437-1446. doi:10.1002/cmdc.201800213

Arouna, O., Deluca, F., Camara, M., Fall, B., Fall, B., Ba Diallo, A., Docquier, J.-D., & Mboup, S. (2017). Chryseobacterium gleum in a man with prostatectomy in Senegal: A case report and review of the literature. Journal of Medical Case Reports, 11 (1). doi:10.1186/s13256-017-1269-4

Lee, K., Yong, D., Jeong, S. H., Tulgaa, K., Docquier, J.-D., Rossolini, G. M., & Chong, Y. (2017). Genetic and biochemical characterisation of CTX-M-37 extended-spectrum β-lactamase from an Enterobacter cloacae clinical isolate from Mongolia. Journal of Global Antimicrobial Resistance, 10, 3-7. doi:10.1016/j.jgar.2017.03.007

Maccari, G., Deodato, D., Fiorucci, D., Orofino, F., Truglio, G. I., Pasero, C., Martini, R., De Luca, F., Docquier, J.-D., & Botta, M. (2017). Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol. Bioorganic and Medicinal Chemistry Letters, 27 (15), 3332-3336. doi:10.1016/j.bmcl.2017.06.016

Santucci, M., Spyrakis, F., Cross, S., Quotadamo, A., Farina, D., Tondi, D., De Luca, F., Docquier, J.-D., Prieto, A. I., Ibacache, C., Blázquez, J., Venturelli, A., Cruciani, G., & Costi, M. P. (2017). Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases. Scientific Reports, 7 (1). doi:10.1038/s41598-017-17399-7

Sevaille, L., Gavara, L., Bebrone, C., De Luca, F., Nauton, L., Achard, M., Mercuri, P., Tanfoni, S., Borgianni, L., Guyon, C., Lonjon, P., Turan-Zitouni, G., Dzieciolowski, J., Becker, K., Bénard, L., Condon, C., Maillard, L., Martinez, J., Frère, J.-M., & Hernandez, J.-F. (2017). 1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases. ChemMedChem, 12, 972-985. doi:10.1002/cmdc.201700186

Zamperini, C., MacCari, G., Deodato, D., Pasero, C., D'Agostino, I., Orofino, F., De Luca, F., Dreassi, E., Docquier, J.-D., & Botta, M. (2017). Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents. Scientific Reports, 7 (1). doi:10.1038/s41598-017-08749-6

Brindisi, M., Brogi, S., Giovani, S., Gemma, S., Lamponi, S., De Luca, F., Novellino, E., Campiani, G., Docquier, J.-D., & Butini, S. (2016). Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 31, 98-109. doi:10.3109/14756366.2016.1172575

Deodato, D., Maccari, G., De Luca, F., Sanfilippo, S., Casian, A., Martini, R., D'Arezzo, S., Bonchi, C., Bugli, F., Posteraro, B., Vandeputte, P., Sanglard, D., Docquier, J.-D., Sanguinetti, M., Visca, P., & Botta, M. (2016). Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound. Journal of Medicinal Chemistry, 59 (8), 3854-3866. doi:10.1021/acs.jmedchem.6b00018

Docquier, J.-D., & Mangani, S. (2016). Structure-Function Relationships of Class D Carbapenemases. Current Drug Targets, 17 (9), 1061-1071. doi:10.2174/1389450116666150825115824

Gudeta, D. D., Bortolaia, V., Pollini, S., Docquier, J.-D., Rossolini, G. M., Amos, G. C. A., Wellington, E. M. H., & Guardabassi, L. (2016). Expanding the repertoire of carbapenem-hydrolyzing metallo-β-lactamases by functional metagenomic analysis of soil microbiota. Frontiers in Microbiology, 7 (DEC). doi:10.3389/fmicb.2016.01985

Gudeta, D. D., Pollini, S., Docquier, J.-D., Bortolaia, V., Rossolini, G. M., & Guardabassi, L. (2016). Biochemical characterization of CPS-1, a subclass B3 metallo-β-lactamase from a Chryseobacterium piscium soil isolate. Antimicrobial Agents and Chemotherapy, 60 (3), 1869-1873. doi:10.1128/AAC.01924-15

Landini, G., Di Maggio, T., Sergio, F., Docquier, J.-D., Rossolini, G. M., & Pallecchi, L. (2016). Effect of high N-acetylcysteine concentrations on antibiotic activity against a large collection of respiratory pathogens. Antimicrobial Agents and Chemotherapy, 60 (12), 7513-7517. doi:10.1128/AAC.01334-16

Pozzi, C., De Luca, F., Benvenuti, M., Poirel, L., Nordmann, P., Rossolini, G. M., Mangani, S., & Docquier, J.-D. (2016). Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem. Antimicrobial Agents and Chemotherapy, 60 (12), 7189-7199. doi:10.1128/AAC.00936-16

Sgrignani, J., De Luca, F., Torosyan, H., Docquier, J.-D., Duan, D., Novati, B., Prati, F., Colombo, G., & Grazioso, G. (2016). Structure-based approach for identification of novel phenylboronic acids as serine-β-lactamase inhibitors. Journal of Computer-Aided Molecular Design, 30 (10), 851-861. doi:10.1007/s10822-016-9962-8

Antonelli, A., D'Andrea, M. M., Vaggelli, G., Docquier, J.-D., & Rossolini, G. M. (2015). OXA-372, a novel carbapenem-hydrolysing class D β-lactamase from a Citrobacter freundii isolated from a hospital wastewater plant. Journal of Antimicrobial Chemotherapy, 70 (10), 2749-2756. doi:10.1093/jac/dkv181

Borgianni, L., De Luca, F., Thaller, M. C., Chong, Y., Rossolini, G. M., & Docquier, J.-D. (2015). Biochemical characterization of the POM-1 metallo-β-lactamase from Pseudomonas otitidis. Antimicrobial Agents and Chemotherapy, 59 (3), 1755-1758. doi:10.1128/AAC.03843-14

Lahiri, S. D., Mangani, S., Jahić, H., Benvenuti, M., Durand-Reville, T. F., De Luca, F., Ehmann, D. E., Rossolini, G. M., Alm, R. A., & Docquier, J.-D. (2015). Molecular basis of selective inhibition and slow reversibility of avibactam against class D carbapenemases: A structure-guided study of OXA-24 and OXA-48. ACS Chemical Biology, 10 (2), 591-600. doi:10.1021/cb500703p

Lahlaoui, H., De Luca, F., Maradel, S., Ben-Haj-Khalifa, A., Ben Hamouda, H., Kheder, M., Ben Moussa, M., Rossollini, G. M., & Docquier, J.-D. (2015). Occurrence of conjugative IncF-type plasmids harboring the bla CTX-M-15 gene in Enterobacteriaceae isolates from newborns in Tunisia. Pediatric Research, 77 (1), 107-110. doi:10.1038/pr.2014.153

Papagiannitsis, C. C., Pollini, S., De Luca, F., Rossolini, G. M., Docquier, J.-D., & Hrabák, J. (2015). Biochemical characterization of VIM-39, a VIM-1-like metallo-β-lactamase variant from a multidrug-resistant Klebsiella pneumoniae isolate from Greece. Antimicrobial Agents and Chemotherapy, 59 (12), 7811-7814. doi:10.1128/AAC.01935-15

Docquier, J.-D., & Cusi, M. G. (2014). Editorial overview: Anti-infectives: Towards novel antiviral and antibacterial drugs? Current approaches to address a growing medical need. Current Opinion in Pharmacology, 18. doi:10.1016/j.coph.2014.10.004

Maccari, G., Sanfilippo, S., De Luca, F., Deodato, D., Casian, A., Dasso Lang, M. C., Zamperini, C., Dreassi, E., Rossolini, G. M., Docquier, J.-D., & Botta, M. (2014). Synthesis of linear and cyclic guazatine derivatives endowed with antibacterial activity. Bioorganic and Medicinal Chemistry Letters, 24 (23), 5525-5529. doi:10.1016/j.bmcl.2014.09.081

Lahiri, S. D., Mangani, S., Durand-Reville, T., Benvenuti, M., De Luca, F., Sanyal, G., & Docquier, J.-D. (2013). Structural insight into potent broad-spectrum inhibition with reversible recyclization mechanism: Avibactam in complex with CTX-M-15 and pseudomonas aeruginosa AmpC β-lactamases. Antimicrobial Agents and Chemotherapy, 57 (6), 2496-2505. doi:10.1128/AAC.02247-12

Pollini, S., Maradei, S., Pecile, P., Olivo, G., Luzzaro, F., Docquier, J.-D., & Rossolini, G. M. (2013). FIM-1, a new acquired metallo-β-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy. Antimicrobial Agents and Chemotherapy, 57 (1), 410-416. doi:10.1128/AAC.01953-12

Docquier, J.-D., Rossolini, G. M., Nikaido, H., & Frère, J.-M. (2012). Interplay between beta-lactamase activity, outer membrane and active efflux system. In J.-M. Frère, Beta-Lactamases (pp. 401-418). New York, United States: Nova Science Publishers, Inc.

Gualdi, L., Hayre, J. K., Gerlini, A., Bidossi, A., Colomba, L., Trappetti, C., Pozzi, G., Docquier, J.-D., Andrew, P., Ricci, S., & Oggioni, M. R. (2012). Regulation of neuraminidase expression in Streptococcus pneumoniae. BMC Microbiology, 12. doi:10.1186/1471-2180-12-200

Hayre, J. K., Xu, G., Borgianni, L., Taylor, G. L., Andrew, P. W., Docquier, J.-D., & Oggioni, M. R. (2012). Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases. BMC Biochemistry, 13 (1). doi:10.1186/1471-2091-13-19

Borgianni, L., Prandi, S., Salden, L., Santella, G., Hanson, N. D., Rossolini, G. M., & Docquier, J.-D. (2011). Genetic context and biochemical characterization of the IMP-18 metallo-β-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. Antimicrobial Agents and Chemotherapy, 55 (1), 140-145. doi:10.1128/AAC.00858-10

De Luca, F., Benvenuti, M., Carboni, F., Pozzi, C., Rossolini, G. M., Mangani, S., & Docquier, J.-D. (2011). Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D β-lactamase OXA-10 by rational protein design. Proceedings of the National Academy of Sciences of the United States of America, 108 (45), 18424-18429. doi:10.1073/pnas.1110530108

Docquier, J.-D., Benvenuti, M., Calderone, V., Rossolini, G.-M., & Mangani, S. (2011). Structure of the extended-spectrum β-lactamase TEM-72 inhibited by citrate. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 67 (3), 303-306. doi:10.1107/S1744309110054680

Lassaux, P., Traoré, D., Loisel, E., Favier, A., Docquier, J.-D., Sohier, J., Laurent, C., Bebrone, C., Frère, J.-M., Ferrer, J.-L., & Galleni, M. (2011). Biochemical and structural characterization of the subclass B1 metallo-β-lactamase VIM-4. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.01486-09

Lee, K., Yum, J. H., Yong, D., Jeong, S. H., Rossolini, G. M., Docquier, J.-D., & Chong, Y. (2011). Biochemical characterization of the TEM-107 extended-spectrum β-lactamase in a Klebsiella pneumoniae isolate from South Korea. Antimicrobial Agents and Chemotherapy, 55 (12), 5930-5932. doi:10.1128/AAC.05341-11

Santella, G., Docquier, J.-D., Gutkind, G., Rossolini, G. M., & Radice, M. (2011). Purification and biochemical characterization of IMP-13 metallo-β-lactamase. Antimicrobial Agents and Chemotherapy, 55 (1), 399-401. doi:10.1128/AAC.00421-10

Santella, G., Pollini, S., Docquier, J.-D., Almuzara, M., Gutkind, G., Rossolini, G. M., & Radice, M. (2011). Resistencia a carbapenemes en aislamientos de Pseudomonas aeruginosa: Un ejemplo de interacción entre distintos mecanismos. Revista Panamericana de Salud Publica/Pan American Journal of Public Health, 30 (6), 545-548. doi:10.1590/S1020-49892011001200008

Borgianni, L., Vandenameele, J., Matagne, A., Bini, L., Bonomo, R. A., Frère, J.-M., Rossolini, G. M., & Docquier, J.-D. (2010). Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. Antimicrobial Agents and Chemotherapy, 54 (8), 3197-204. doi:10.1128/AAC.01336-09

De Luca, F., Giraud-Morin, C., Rossolini, G. M., Docquier, J.-D., & Fosse, T. (2010). Genetic and biochemical characterization of TRU-1, the endogenous class C β-lactamase from Aeromonas enteropelogenes. Antimicrobial Agents and Chemotherapy, 54 (4), 1547-1554. doi:10.1128/AAC.01252-09

Docquier, J.-D., Benvenuti, M., Calderone, V., Giuliani, F., Kapetis, D., De Luca, F., Rossolini, G. M., & Mangani, S. (2010). Crystal structure of the narrow-spectrum OXA-46 class D β-lactamase: Relationship between active-site lysine carbamylation and inhibition by polycarboxylates. Antimicrobial Agents and Chemotherapy, 54 (5), 2167-2174. doi:10.1128/AAC.01517-09

Docquier, J.-D., Benvenuti, M., Calderone, V., Stoczko, M., Menciassi, N., Rossolini, G. M., & Mangani, S. (2010). High-resolution crystal structure of the subclass B3 metallo-β- lactamase BJP-1: Rational basis for substrate specificity and interaction with sulfonamides. Antimicrobial Agents and Chemotherapy, 54 (10), 4343-4351. doi:10.1128/AAC.00409-10

Lee, K., Kim, C. K., Hong, S. G., Choi, J., Song, S., Koh, E., Yong, D., Jeong, S. H., Yum, J. H., Docquier, J.-D., Rossolini, G. M., & Chong, Y. (2010). Characteristics of clinical isolates of Acinetobacter genomospecies 10 carrying two different metallo-β-lactamases. International Journal of Antimicrobial Agents, 36 (3), 259-263. doi:10.1016/j.ijantimicag.2010.05.018

Lee, K., Kim, C. K., Yong, D., Jeong, S. H., Yum, J. H., Seo, Y. H., Docquier, J.-D., & Chong, Y. (2010). Improved performance of the modified Hodge test with MacConkey agar for screening carbapenemase-producing Gram-negative bacilli. Journal of Microbiological Methods, 83 (2), 149-152. doi:10.1016/j.mimet.2010.08.010

Poirel, L., Docquier, J.-D., De Luca, F., Verlinde, A., Ide, L., Rossolini, G. M., & Nordmann, P. (2010). BEL-2, an extended-spectrum β-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 54 (1), 533-535. doi:10.1128/AAC.00859-09

Santella, G., Pollini, S., Docquier, J.-D., Mereuta, A. I., Gutkind, G., Rossolini, G. M., & Radice, M. (2010). Intercontinental dissemination of IMP-13-producing Pseudomonas aeruginosa belonging in sequence type 621. Journal of Clinical Microbiology, 48 (11), 4342-4343. doi:10.1128/JCM.00614-10

Docquier, J.-D., Calderone, V., De Luca, F., Benvenuti, M., Giuliani, F., Bellucci, L., Tafi, A., Nordmann, P., Botta, M., Rossolini, G. M., & Mangani, S. (2009). Crystal Structure of the OXA-48 β-Lactamase Reveals Mechanistic Diversity among Class D Carbapenemases. Chemistry and Biology, 16 (5), 540-547. doi:10.1016/j.chembiol.2009.04.010

Zeba, B., De Luca, F., Dubus, A., Delmarcelle, M., Simporé, J., Nacoulma, O. G., Rossolini, G. M., Frère, J.-M., & Docquier, J.-D. (2009). IND-6, a Highly Divergent IND-type Metallo-{beta}-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.01607-08

MEEX, C., MELIN, P., Docquier, J.-D., Kabasele, T., HUYNEN, P., Tulkens, P., Giet, D., & De Mol, P. (2008). Presenec of extended-spectrum beta-lactamase-producing Enterobacteriaceae in the fecal flora of patients from general practice. In ECCMID (Ed.), Program and Abstracts book of the 18th ECCMID.

Cagnacci, S., Gualco, L., Roveta, S., Mannelli, S., Borgianni, L., Docquier, J.-D., Dodi, F., Centanaro, M., Debbia, E., Marchese, A., & Rossolini, G. M. (2008). Bloodstream infections caused by multidrug-resistant Klebsiella pneumoniae producing the carbapenem-hydrolysing VIM-1 metallo-β-lactamase: First Italian outbreak. Journal of Antimicrobial Chemotherapy, 61 (2), 296-300. doi:10.1093/jac/dkm471

Garcia-Saez, I., Docquier, J.-D., Rossolini, G. M., & Dideberg, O. (2008). The Three-Dimensional Structure of VIM-2, a Zn-β-Lactamase from Pseudomonas aeruginosa in Its Reduced and Oxidised Form. Journal of Molecular Biology, 375 (3), 604-611. doi:10.1016/j.jmb.2007.11.012

Gori Savellini, G., Di Genova, G., Terrosi, C., Di Bonito, P., Giorgi, C., Valentini, M., Docquier, J.-D., & Cusi, M. G. (2008). Immunization with Toscana virus N-Gc proteins protects mice against virus challenge. Virology, 375 (2), 521-528. doi:10.1016/j.virol.2008.02.006

Michaux, C., Massant, J., Kerff, F., Frère, J.-M., Docquier, J.-D., Vandenberghe, I., Samyn, B., Pierrard, A., Feller, G., Charlier, P., Van Beeumen, J., & Wouters, J. (2008). Crystal structure of a cold-adapted class C beta-lactamase. FEBS Journal, 275 (8), 1687-97. doi:10.1111/j.1742-4658.2008.06324.x

Stoczko, M., Frère, J.-M., Rossolini, G. M., & Docquier, J.-D. (2008). Functional diversity among metallo-β-lactamases: Characterization of the CAR-1 enzyme of Erwinia carotovora. Antimicrobial Agents and Chemotherapy, 52 (7), 2473-2479. doi:10.1128/AAC.01062-07

Cornaglia, G., Akova, M., Amicosante, G., Canton, R., Cauda, R., Docquier, J.-D., Edelstein, M., Frère, J.-M., Fuzi, M., Galleni, M., Giamarellou, H., Gniadkowski, M., Koncan, R., Libisch, B., Luzzaro, F., Miriagou, V., Navarro, F., Nordmann, P., Pagani, L., & Rossolini, G. M. (April 2007). Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues. International Journal of Antimicrobial Agents, 29 (4), 380-388. doi:10.1016/j.ijantimicag.2006.10.008

Docquier, J.-D., & Rossolini, G. M. (2007). Class B β-Lactamases. In R. A. Bonomo & M. Tolmasky, Enzyme-Mediated Resistance to Antibiotics. Mechanisms, Dissemination and Prospects for Inhibition (pp. 115-144). Washington, United States: ASM Press.

Perilli, M., Caporale, B., Celenza, G., Pellegrini, C., Docquier, J.-D., Mezzatesta, M., Rossolini, G. M., Stefani, A., & Amicosante, G. (2007). Identification and characterization of a new metallo-β-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. Antimicrobial Agents and Chemotherapy, 51 (8), 2988-2990. doi:10.1128/AAC.00083-07

Rossolini, G. M., Mantengoli, E., Docquier, J.-D., Musmanno, R. A., & Coratza, G. (2007). Epidemiology of infections caused by multiresistant Gram-negatives: ESBLs, MBLs, panresistant strains. New Microbiologica, 30 (3), 332-339.

Zeba, B., Kiendrébeogo, M., Lamien, A., Docquier, J.-D., Simporé, J., & Nacoulma, O. G. (2007). Major enzymatic factors involved in bacterial penicillin resistance in Burkina Faso. Pakistan Journal of Biological Sciences, 10 (3), 506-510. doi:10.3923/pjbs.2007.506.510

CHRISTIAENS, G., Damas, P., Docquier, J.-D., HAYETTE, M.-P., MELIN, P., & De Mol, P. (2006). Molecular epidemiology of extended-spectrum beta-lactamase-producing Enterobacteriaceae colonizing the digestive tract of patients admitted to intensive care units in a Belgian university hospital. In American Society of Microbiology (Ed.), Program and Abstracts of the 46th Intersciences Conference on Antimicrobial Agents and Chemotherapy (pp. 2-105). Washington, United States: American Society for Microbiology (ASM).

Rossolini, G. M., & Docquier, J.-D. (2006). New β-lactamases: A paradigm for the rapid response of bacterial evolution in the clinical setting. Future Microbiology, 1 (3), 295-308. doi:10.2217/17460913.1.3.295

Stoczko, M., Frère, J.-M., Rossolini, G. M., & Docquier, J.-D. (2006). Postgenomic scan of metallo-β-lactamase homologues in rhizobacteria: Identification and characterization of BJP-1, a subclass B3 ortholog from Bradyrhizobium japonicum. Antimicrobial Agents and Chemotherapy, 50 (6), 1973-1981. doi:10.1128/AAC.01551-05

Voha, C., Docquier, J.-D., Rossolini, G. M., & Fosse, T. (2006). Genetic and biochemical characterization of FUS-1 (OXA-85), a narrow-spectrum class D β-lactamase from Fusobacterium nucleatum subsp. polymorphum. Antimicrobial Agents and Chemotherapy, 50 (8), 2673-2679. doi:10.1128/AAC.00058-06

Giuliani, F., Docquier, J.-D., Riccio, M. L., Pagani, L., & Rossolini, G. M. (2005). OXA-46, a new class D β-lactamase of narrow substrate specificity encoded by a blaVIM-1-containing integron from a Pseudomonas aeruginosa clinical isolate. Antimicrobial Agents and Chemotherapy, 49 (5), 1973-1980. doi:10.1128/AAC.49.5.1973-1980.2005

Lee, K., Yum, J. H., Yong, D., Lee, H. M., Kim, H. D., Docquier, J.-D., Rossolini, G. M., & Chong, Y. (2005). Novel acquired metallo-β-lactamase gene, blaSIM-1, in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea. Antimicrobial Agents and Chemotherapy, 49 (11), 4485-4491. doi:10.1128/AAC.49.11.4485-4491.2005

Pagani, L., Colinon, C., Migliavacca, R., Labonia, M., Docquier, J.-D., Nucleo, E., Spalla, M., Bergoli, M. L., & Rossolini, G. M. (2005). Nosocomial outbreak caused by multidrug-resistant Pseudomonas aeruginosa producing IMP-13 metallo-β-lactamase. Journal of Clinical Microbiology, 43 (8), 3824-3828. doi:10.1128/JCM.43.8.3824-3828.2005

Riccio, M. L., Pallecchi, L., Docquier, J.-D., Cresti, S., Catania, M. R., Pagani, L., Lagatolla, C., Cornaglia, G., Fontana, R., & Rossolini, G. M. (2005). Clonal relatedness and conserved integron structures in epidemiologically unrelated Pseudomonas aeruginosa strains producing the VIM-1 metallo-β-lactamase from different Italian hospitals. Antimicrobial Agents and Chemotherapy, 49 (1), 104-110. doi:10.1128/AAC.49.1.104-110.2005

Docquier, J.-D., Lopizzo, T., Liberatori, S., Prenna, M., Thaller, M. C., Frère, J.-M., & Rossolini, G. M. (2004). Biochemical characterization of the THIN-B metallo-β-lactamase of Janthinobacterium lividum. Antimicrobial Agents and Chemotherapy, 48 (12), 4778-4783. doi:10.1128/AAC.48.12.4778-4783.2004

Luzzaro, F., Docquier, J.-D., Colinon, C., Endimiani, A., Lombardi, G., Amicosante, G., Rossolini, G. M., & Toniolo, A. (2004). Emergence in Klebsiella pneumoniae and Enterobacter cloacae Clinical Isolates of the VIM-4 Metallo-β-Lactamase Encoded by a Conjugative Plasmid. Antimicrobial Agents and Chemotherapy, 48 (2), 648-650. doi:10.1128/AAC.48.2.648-650.2004

Luzzaro, F., Endimiani, A., Docquier, J.-D., Mugnaioli, C., Bonsignori, M., Amicosante, G., Rossolini, G. M., & Toniolo, A. (2004). Prevalence and characterization of metallo-β-lactamases in clinical isolates of Pseudomonas aeruginosa. Diagnostic Microbiology and Infectious Disease, 48 (2), 131-135. doi:10.1016/j.diagmicrobio.2003.09.005

Docquier, J.-D., Lamotte-Brasseur, J., Galleni, M., Amicosante, G., Frère, J.-M., & Rossolini, G. M. (February 2003). On functional and structural heterogeneity of VIM-type metallo-beta-lactamases. Journal of Antimicrobial Chemotherapy, 51 (2), 257-266. doi:10.1093/jac/dkg067

Docquier, J.-D., Riccio, M. L., Mugnaioli, C., Luzzaro, F., Endimiani, A., Toniolo, A., Amicosante, G., & Rossolini, G. M. (2003). IMP-12, a new plasmid-encoded metallo-β-lactamase from a Pseudomonas putida clinical isolate. Antimicrobial Agents and Chemotherapy, 47 (5), 1522-1528. doi:10.1128/AAC.47.5.1522-1528.2003

Forleo, C., Benvenuti, M., Calderone, V., Schippa, S., Docquier, J.-D., Cristina Thaller, M., Rossolini, G. M., & Mangani, S. (2003). Expression, purification, crystallization and preliminary X-ray characterization of the class B acid phosphatase (AphA) from Escherichia coli. Acta Crystallographica. Section D, Biological Crystallography, 59 (6), 1058-1060. doi:10.1107/S0907444903006826

Riccio, M. L., Docquier, J.-D., Dell'Amico, E., Luzzaro, F., Amicosante, G., & Rossolini, G. M. (2003). Novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron. Antimicrobial Agents and Chemotherapy, 47 (5), 1746-1748. doi:10.1128/AAC.47.5.1746-1748.2003

Docquier, J.-D., Pantanella, F., Giuliani, F., Thaller, M. C., Amicosante, G., Galleni, M., Frère, J.-M., Bush, K., & Rossolini, G. M. (June 2002). CAU-1, a subclass B3 metallo-beta-lactamase of low substrate affinity encoded by an ortholog present in the Caulobacter crescentus chromosome. Antimicrobial Agents and Chemotherapy, 46 (6), 1823-1830. doi:10.1128/AAC.46.6.1823-1830.2002

Vessillier, S., Docquier, J.-D., Rival, S., Frère, J.-M., Galleni, M., Amicosante, G., Rossolini, G. M., & Franceschini, N. (June 2002). Overproduction and biochemical characterization of the Chryseobacterium meningosepticum BlaB metallo-beta-lactamase. Antimicrobial Agents and Chemotherapy, 46 (6), 1921-1927. doi:10.1128/AAC.46.6.1921-1927.2002

Lombardi, G., Luzzaro, F., Docquier, J.-D., Riccio, M. L., Perilli, M., Colì, A., Amicosante, G., Rossolini, G. M., & Toniolo, A. (2002). Nosocomial infections caused by multidrug-resistant isolates of Pseudomonas putida producing VIM-1 metallo-β-lactamase. Journal of Clinical Microbiology, 40 (11), 4051-4055. doi:10.1128/JCM.40.11.4051-4055.2002

Migliavacca, R., Docquier, J.-D., Mugnaioli, C., Amicosante, G., Daturi, R., Lee, K., Rossolini, G. M., & Pagani, L. (2002). Simple microdilution test for detection of metallo-β-lactamase production in pseudomonas aeruginosa. Journal of Clinical Microbiology, 40 (11), 4388-4390. doi:10.1128/JCM.40.11.4388-4390.2002

Bebrone, C., Moali, C., Mahy, F., Rival, S., Docquier, J.-D., Rossolini, G. M., Fastrez, J., Pratt, R. F., Frère, J.-M., & Galleni, M. (June 2001). Centa as a Chromogenic Substrate for Studying Beta-Lactamases. Antimicrobial Agents and Chemotherapy, 45 (6), 1868-71. doi:10.1128/AAC.45.6.1868-1871.2001

Duez, C., Vanhove, M., Gallet, X., Bouillenne, F., Docquier, J.-D., Brans, A., & Frère, J.-M. (March 2001). Purification and Characterization of Pbp4a, a New Low-Molecular-Weight Penicillin-Binding Protein from Bacillus subtilis. Journal of Bacteriology, 183 (5), 1595-9. doi:10.1128/JB.183.5.1595-1599.2001

Docquier, J.-D., Luzzaro, F., Amicosante, G., Toniolo, A., & Rossolini, G. M. (2001). Multidrug-resistant Pseudomonas aeruginosa producing PER-1 extended-spectrum serine-β-lactamase and VIM-2 metallo-β-lactamase [letter to the editor]. Emerging Infectious Diseases, 7 (5), 910-911. doi:10.3201/eid0705.010528

Pallecchi, L., Riccio, M. L., Docquier, J.-D., Fontana, R., & Rossolini, G. M. (2001). Molecular heterogeneity of blaVIM-2-containing integrons from Pseudomonas aeruginosa plasmids encoding the VIM-2 metallo-β-lactamase. FEMS Microbiology Letters, 195 (2), 145-150. doi:10.1016/S0378-1097(01)00002-7

Rossolini, G. M., Condemi, M. A., Pantanella, F., Docquier, J.-D., Amicosante, G., & Thaller, M. C. (2001). Metallo-β-lactamase producers in environmental microbiota: New molecular class B enzyme in Janthinobacterium lividum. Antimicrobial Agents and Chemotherapy, 45 (3), 837-844. doi:10.1128/AAC.45.3.837-844.2001

Franceschini, N., Caravelli, B., Docquier, J.-D., Galleni, M., Frère, J.-M., Amicosante, G., & Rossolini, G. M. (2000). Purification and biochemical characterization of the VIM-1 metallo-beta-lactamase. Antimicrobial Agents and Chemotherapy, 44 (11), 3003-7. doi:10.1128/AAC.44.11.3003-3007.2000

Pierrard, A., Ledent, P., Docquier, J.-D., Feller, G., Gerday, C., & Frère, J.-M. (1998). Inducible class C beta-lactamases produced by psychrophilic bacteria. FEMS Microbiology Letters, 161, 311-315. doi:10.1016/S0378-1097(98)00088-3