Publications of Bernard Rogister
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See detail"Opter pour l'obligation vaccinale est un choix de société"
Muraille, Eric; De Kerchove d'Exaerde, Alban; Drion, Pierre ULiege et al

Article for general public (2021)

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See detailThe Subventricular Zone, a Hideout for Adult and Pediatric High-Grade Glioma Stem Cells
LOMBARD, Arnaud ULiege; Di Gregorio, Marina ULiege; Delcamp, Clément ULiege et al

in Frontiers in Oncology (2021)

Both in adult and children, high-grade gliomas (WHO grades III and IV) account for a high proportion of death due to cancer. This poor prognosis is a direct consequence of tumor recurrences occurring ... [more ▼]

Both in adult and children, high-grade gliomas (WHO grades III and IV) account for a high proportion of death due to cancer. This poor prognosis is a direct consequence of tumor recurrences occurring within few months despite a multimodal therapy consisting of a surgical resection followed by chemotherapy and radiotherapy. There is increasing evidence that glioma stem cells (GSCs) contribute to tumor recurrences. In fact, GSCs can migrate out of the tumor mass and reach the subventricular zone (SVZ), a neurogenic niche persisting after birth. Once nested in the SVZ, GSCs can escape a surgical intervention and resist to treatments. The present review will define GSCs and describe their similarities with neural stem cells, residents of the SVZ. The architectural organization of the SVZ will be described both for humans and rodents. The migratory routes taken by GSCs to reach the SVZ and the signaling pathways involved in their migration will also be described hereafter. In addition, we will debate the advantages of the microenvironment provided by the SVZ for GSCs and how this could contribute to tumor recurrences. Finally, we will discuss the clinical relevance of the SVZ in adult GBM and pediatric HGG and the therapeutic advantages of targeting that neurogenic region in both clinical situations. [less ▲]

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See detailCorrection: In Vivo Tumorigenesis Was Observed after Injection of In Vitro Expanded Neural Crest Stem Cells Isolated from Adult Bone Marrow.
Wislet-Gendebien, Sabine; Poulet, Christophe ULiege; Neirinckx, Virginie ULiege et al

in PLoS ONE (2021), 16(9), 0256477

[This corrects the article DOI: 10.1371/journal.pone.0046425.].

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See detailOnly GABAergic neurons induced seizures following SV2A recombination
Bartholomé, Odile ULiege; Van den ackerveken, Priscilla; de la Brassinne, Orianne et al

Poster (2020, July 11)

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See detailExploring with [(18)F]UCB-H the in vivo Variations in SV2A Expression through the Kainic Acid Rat Model of Temporal Lobe Epilepsy.
Serrano Navacerrada, Maria Elisa ULiege; Bahri, Mohamed Ali ULiege; Becker, Guillaume ULiege et al

in Molecular imaging and biology (2020)

PURPOSE: The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal ... [more ▼]

PURPOSE: The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model. PROCEDURES: Twenty Sprague Dawley male rats were administered with multiple systemic doses of saline (control group, n = 5) or kainic acid (5 mg/kg/injection, epileptic group, n = 15). Both groups were scanned at the four phases of TLE (early, latent, transition, and chronic phase) with the [(18)F]UCB-H PET radiotracer and T2-structural magnetic resonance imaging. At the end of the scans (3 months post-status epilepticus), rats were monitored for 7 days with electroencephalography for the detection of spontaneous electrographic seizures. Finally, the immunofluorescence staining for SV2A expression was performed. RESULTS: Control rats presented a significant increase in [(18)F]UCB-H binding at the last two scans, compared with the first ones (p < 0.001). This increase existed but was lower in epileptic animals, producing significant group differences in all the phases of the disease (p < 0.028). Furthermore, the quantification of the SV2A expression in vivo with the [(18)F]UCB-H radiotracer or ex vivo with immunofluorescence led to equivalent results, with a positive correlation between both. CONCLUSIONS: Even if further studies in humans are required, the ability to detect a progressive decrease in SV2A expression during the development of temporal lobe epilepsy supports the use of [(18)F]UCB-H as a useful tool to differentiate, in vivo, between healthy and epileptic animals along with the development of the epileptic disease. [less ▲]

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See detailA Composite Sketch of Fast-spiking Parvalbumin-positive Neurons
Bartholomé, Odile ULiege; de la Brassinne Bonardeaux, Orianne ULiege; Neirinckx, Virginie ULiege et al

in Cerebral Cortex Communication (2020)

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See detailRelevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential.
Di Gregorio, Marina ULiege; LOMBARD, Arnaud ULiege; Lumapat, Paul Noel ULiege et al

in Cells (2019)

Cancer cells are continually exposed to environmental stressors forcing them to adapt their protein production to survive. The translational machinery can be recruited by malignant cells to synthesize ... [more ▼]

Cancer cells are continually exposed to environmental stressors forcing them to adapt their protein production to survive. The translational machinery can be recruited by malignant cells to synthesize proteins required to promote their survival, even in times of high physiological and pathological stress. This phenomenon has been described in several cancers including in gliomas. Abnormal regulation of translation has encouraged the development of new therapeutics targeting the protein synthesis pathway. This approach could be meaningful for glioma given the fact that the median survival following diagnosis of the highest grade of glioma remains short despite current therapy. The identification of new targets for the development of novel therapeutics is therefore needed in order to improve this devastating overall survival rate. This review discusses current literature on translation in gliomas with a focus on the initiation step covering both the cap-dependent and cap-independent modes of initiation. The different translation initiation protagonists will be described in normal conditions and then in gliomas. In addition, their gene expression in gliomas will systematically be examined using two freely available datasets. Finally, we will discuss different pathways regulating translation initiation and current drugs targeting the translational machinery and their potential for the treatment of gliomas. [less ▲]

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See detailThe Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment
Reynders, Nathan; Abboud, Dayana ULiege; Baragli, Alexandra et al

in Cells (2019), 8(6),

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See detailAnxiety-like features and spatial memory problems as a consequence of hippocampal SV2A expression.
Serrano Navacerrada, Maria Elisa ULiege; Bartholomé, Odile ULiege; Van den Ackerveken, Priscillia et al

in PLoS ONE (2019)

The Synaptic Vesicle Protein 2A (SV2A) is a transmembrane protein whose presence is reduced both in animal models and in patients with chronic epilepsy. Besides its implication in the epileptic process ... [more ▼]

The Synaptic Vesicle Protein 2A (SV2A) is a transmembrane protein whose presence is reduced both in animal models and in patients with chronic epilepsy. Besides its implication in the epileptic process, the behavioural consequences of the changes in its expression remain unclear. The purpose of our research is to better understand the possible role(s) of this protein through the phenotype of cKO (Grik4 Cre+/-, SV2A lox/lox) mice, male and female, which present a specific decrease of SV2A expression levels in the hippocampal glutamatergic neurons but without any epileptic seizures. In this study, we compare the cKO mice with cHZ (Grik4 Cre+/-, SV2A lox/+) and WT (Grik4 Cre+/+, SV2A lox/lox) mice through a battery of tests, used to evaluate different features: the anxiety-related features (Elevated Plus Maze), the locomotor activity (Activity Chambers), the contextual fear-related memory (Contextual Fear Conditioning), and the spatial memory (Barnes Maze). Our results showed statistically significant differences in the habituation to a new environment, an increase in the anxiety levels and spatial memory deficit in the cHZ and cKO groups, compared to the WT group. No statistically significant differences due to the genotype appeared in the spontaneous locomotor activity or the fear-linked memory. However, sexual differences were observed in this last feature. These results highlight not only an important role of the SV2A protein in the cognitive and anxiety problems typically encountered in epileptic patients, but also a possible role in the symptomatology of other neurodegenerative diseases, such as the Alzheimer’s disease. [less ▲]

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See detailEccentric Muscle Contractions: Risks and Benefits.
Hody, Stéphanie ULiege; Croisier, Jean-Louis ULiege; Bury, Thierry ULiege et al

in Frontiers in Physiology (2019)

Eccentric contractions, characterized by the lengthening of the muscle-tendon complex, present several unique features compared with other types of contractions, which may lead to unique adaptations. Due ... [more ▼]

Eccentric contractions, characterized by the lengthening of the muscle-tendon complex, present several unique features compared with other types of contractions, which may lead to unique adaptations. Due to its specific physiological and mechanical properties, there is an increasing interest in employing eccentric muscle work for rehabilitation and clinical purposes. However, unaccustomed eccentric exercise is known to cause muscle damage and delayed pain, commonly defined as "Delayed-Onset Muscular Soreness" (DOMS). To date, the most useful preventive strategy to avoid these adverse effects consists of repeating sessions involving submaximal eccentric contractions whose intensity is progressively increased over the training. Despite an increased number of investigations focusing on the eccentric contraction, a significant gap still remains in our understanding of the cellular and molecular mechanisms underlying the initial damage response and subsequent adaptations to eccentric exercise. Yet, unraveling the molecular basis of exercise-related muscle damage and soreness might help uncover the mechanistic basis of pathological conditions as myalgia or neuromuscular diseases. In addition, a better insight into the mechanisms governing eccentric training adaptations should provide invaluable information for designing therapeutic interventions and identifying potential therapeutic targets. [less ▲]

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See detailLongitudinal in vivo evaluation of brain synaptic density with [18F]UCB-H through the different phases in the kainic acid rat model of temporal lobe epilepsy.
Serrano Navacerrada, Maria Elisa ULiege; Bahri, Mohamed Ali ULiege; Becker, Guillaume ULiege et al

Conference (2019, March 19)

Epilepsy is one of the most common neurological disorders, affecting around 65 million people worldwide. Since some of the most efficient antiepileptic drugs target the SV2A protein, different ... [more ▼]

Epilepsy is one of the most common neurological disorders, affecting around 65 million people worldwide. Since some of the most efficient antiepileptic drugs target the SV2A protein, different radiotracers have been developed to detect and monitor its variations in the epileptic disease, being proposed as synaptic density markers. Our research focus on the longitudinal SV2A quantification in different brain regions of the kainic acid rat model of temporal lobe epilepsy, using the [18F]UCB-H radiotracer. Furthermore, we evaluated the relationship between these variations and three EEG parameters: the number of electrographic seizures per week and their mean and total duration. In addition, we have confirmed the correct development of our model and the [18F]UCB-H results by means of the magnetic resonance imaging (performed in parallel to [18F]UCB-H scans), the electroencephalography technique (during one week after PET imaging), and the SV2A immunofluorescence (performed at the end of the electroencephalography). Our quantitative analyses evidence a progressive decrease in the synaptic density in all the brain regions assessed, showcasing the ability of the [18F]UCB-H to detect and monitor variations in the synaptic density through the epileptic disease. Furthermore, the epileptic animals which suffered the highest number of electrographic seizures were those presenting the lowest brain metabolism, but the lowest SV2A decrease. Hence, these first-in-class results highlight not only the utility of [18F]UCB-H as a diagnosis, monitoring and pharmacodynamics/response biomarker, but also they suggest that the [18F]UCB-H uptake reflects the synaptic function in the epileptic group, which suppose a big step understanding the epilepsy. [less ▲]

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See detailConstruction of an oncolytic herpes virus (oHSV) for inducing apoptosis in glioblastoma: proof of concept
Sanchez Gil, Judith ULiege; Collignon, Alice; Lebrun, Marielle et al

Poster (2019, January 15)

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