Publications of Michel Frederich
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See detailA new isoquinoline and ceramide from the stem barks of Discoglypremna caloneura (Pax) Prain (Euphorbiaceae) with antiproteinase and cytotoxic activities.
Toukam, Paul Djouonzo; Kom, Christelle Wayoue; Tchamgoué, Armelle Deutou et al

in Natural Product Research (2021)

Two new compounds, an isoquinoline (1) and caloneuramide (2), a ceramide were isolated from the stem bark of Discoglypremna caloneura together with seven known compounds namely aurantiamide acetate (3 ... [more ▼]

Two new compounds, an isoquinoline (1) and caloneuramide (2), a ceramide were isolated from the stem bark of Discoglypremna caloneura together with seven known compounds namely aurantiamide acetate (3), acetylaleuritolic acid (4), 3α-hydroxylaleuritolic acid 2α-p-hydroxybenzoate (5), mixture of stigmasterol (6) and β-sitosterol (7), mixture of 7-oxo-stigmasterol (8) and 7-oxo-β-sitosterol (9). Their structures were determined based on data from literature and spectroscopic methods. Derivatization reactions on the isoquinoline led to two new compounds, the methylated (10) and acetylated (11) derivatives. Some compounds and extracts were evaluated for their cytotoxic and antiproteinase activity. Antiproteinase effect of compounds 1, 10 and 11 exhibited IC(50) values of 10.77, 1.19 and 3.61 μg/mL respectively; significantly low compared to the standard drug, acetyl salicylic acid (IC(50) = 20.28 μg/mL). Ethyl acetate and methanol extract exhibited moderate cytotoxicity activity on Chang liver cells with CC(50) values of 167.90 ± 2.20 and 106.30 ± 2.03 μg/mL compared to the reference drug cucurmin (CC(50) = 11.05 ± 1.04 μg/mL). [less ▲]

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See detailPhytochemical investigation and biological activities from Lantana rhodesiensis Moldenke.
Nea, Fatimata ULiege; Bitchi, Boni Michel; Genva, Manon ULiege et al

Poster (2021, January 15)

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See detailPhytochemical investigation and biological activities of Lantana rhodesiensis
Nea, Fatimata ULiege; Bitchi, Michel Boni; Genva, Manon ULiege et al

in Molecules (2021), 26(4), 846

Lantana rhodesiensis Moldenke is a plant widely used to treat diseases, such as rheumatism, diabetes, and malaria in traditional medicine. To better understand the traditional uses of this plant, a ... [more ▼]

Lantana rhodesiensis Moldenke is a plant widely used to treat diseases, such as rheumatism, diabetes, and malaria in traditional medicine. To better understand the traditional uses of this plant, a phytochemical study was undertaken, revealing a higher proportion of polyphenols, including flavonoids in L. rhodesiensis leaf extract and moderate proportion in stem and root extracts. The antioxidant activity of the extracts was also determined using three different assays: the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, the FRAP method (Ferric-reducing antioxidant power) and the β-carotene bleaching test. The anti-malarial activity of each extract was also evaluated using asexual erythrocyte stages of Plasmodium falciparum, chloroquine-sensitive strain 3D7. The results showed that the leaf extract exhibited higher antioxidant and anti-malarial activities in comparison with the stem and root extracts, probably due to the presence of higher quantities of polyphenols including flavonoids in the leaves. A positive linear correlation was established between the phenolic compound content (total polyphenols including flavonoids and tannins; and total flavonoids) and the antioxidant activity of all extracts. Furthermore, four flavones were isolated from leaf dichloromethane and ethyl acetate fractions: a new flavone named rhodescine (5,6,3’,5’-tetrahydroxy-7,4’-dimethoxyflavone) (1), 5-hydroxy-6,7,3’,4’,5’-pentamethoxyflavone (2), 5-hydroxy-6,7,3′,4′-tetramethoxyflavone (3), and 5,6,3’-trihydroxy-7,4’-dimethoxyflavone (4). Their structures were elucidated by 1H, 13C NMR, COSY, HSQC, HMBC, and MS-EI spectral methods. Aside from compound 2, all other molecules were described for the first time in this plant species. [less ▲]

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See detailPentas longiflora Oliv. (Rubiaceae), a plant used in the treatment of Pityriasis Versicolor in Rwanda: Chemical composition and standardization of leaves and roots
Kagisha, Vedaste ULiege; Marini Djang'Eing'A, Roland ULiege; Muganga, Raymond et al

in Fitoterapia (2021), 153

In Rwanda, the roots of Pentas longiflora Oliv. (Rubiaceae) have been used for a long time to treat Pityriasis versicolor. However, many people reported the use of leaves instead of roots. This research ... [more ▼]

In Rwanda, the roots of Pentas longiflora Oliv. (Rubiaceae) have been used for a long time to treat Pityriasis versicolor. However, many people reported the use of leaves instead of roots. This research was conducted to compare the phytochemical composition and establish chromatographic methods for the standardization of roots and leaves extracts of P. longiflora. During this process, three new pentalongin glycosides (pentalonginoside A, pentalonginoside B, and pentalonginoside C) and two known glycosides of the same type (harounoside and clarinoside), as well as rutin, luteolin-7-rutinoside were isolated from methanol extract of leaves. In addition, pentalongin and psychorubrin, previously isolated from ethylacetate roots extract, were also identified in Pentas longiflora ethylacetate leaves extract. The presence of the antifungal compound pentalongin in leaves may explain the traditional use of leaves in the treatment of Pytiriasis versicolor. Furthermore, harounoside, psychorubrin, and pentalongin were selected as markers for HPLC fingerprints of MeOH extract. The accuracy and risk profile demonstrated the reliability of the validated method. In general, considerable variations of concentration in plant metabolites, including pentalongin, were observed between samples from different sites. The content in pentalongin (expressed as juglone) in collected samples ranged between 1.7 and 70.0 mg/100 g. The highest concentration (70.0 ± 17 mg/100 g) was registered in the cultivated samples from Mukoni. This important variation of pentalongin concentrations according to sampling sites, shows that in order to guarantee equivalent efficacy, finished products with P. longiflora should be standardized based on their pentalongin content. [less ▲]

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See detailIdentification of a proanthocyanidin from Litchi chinensis Sonn. root with anti-tyrosinase and antioxidant activity
Saive, Matthew ULiege; Genva, Manon ULiege; Istasse, Thibaut ULiege et al

in Biomolecules (2020), 10(9), 1347

This work follows an ethnobotanical study that took place in the island of Mayotte (France), which pointed out the potential properties of Litchi chinensis Sonn. roots when used to enhance skin health and ... [more ▼]

This work follows an ethnobotanical study that took place in the island of Mayotte (France), which pointed out the potential properties of Litchi chinensis Sonn. roots when used to enhance skin health and appearance. Through in vitro testing of a crude methanolic extract, high anti-tyrosinase (skin whitening e ect) and antioxidant activities (skin soothing e ect) could be measured. HPLC successive bio-guided fractionation steps allowed the purification of one of the compounds responsible for the biological activities. The isolated compound was characterized by UV, IR, MS and 2D-NMR, revealing, for the first time in Litchi chinensis Sonn. roots, an A-type proanthocyanidin and thus revealing a consensus among the traditional use shown by the ethnobotanical study, in vitro biological activities and chemical characterization. [less ▲]

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See detailHeparin-Coated Liposomes Improve Antiplasmodial Activity and Reduce the Toxicity of Poupartone B
Ledoux, Allison ULiege; Coelho Cristino Mamede, Lucia Cristina ULiege; Palazzo, Claudio et al

in Planta Medica International Open (2020), 7(e), 7380

Poupartone B is an alkyl cyclohexenone derivative isolated from Poupartia borbonica. This compound demonstrated promising antimalarial activity (IC50 < 1 μg/mL), however, it was not de- void of toxicity ... [more ▼]

Poupartone B is an alkyl cyclohexenone derivative isolated from Poupartia borbonica. This compound demonstrated promising antimalarial activity (IC50 < 1 μg/mL), however, it was not de- void of toxicity. Thus, to reduce the adverse side effects of this natural bioactive molecule, a delivery strategy involving a na- nostructure was formulated. Additionally, poupartone B-load- ed liposomes were coated with heparin, a glycosaminoglycan that is known to target proteins on the surface of Plasmodium falciparum-infected red blood cells. The quantification of the compound in the formulation was performed by HPLC-DAD, while heparin was quantitated by 1H NMR spectroscopy. The liposomes’ antiplasmodial activity was tested on artemisinin- resistant P. falciparum isolate, and toxicity was evaluated on human HeLa cells and zebrafish embryos. Throughout this re- search, the formulation demonstrated higher antiplasmodial activities against both P. falciparum strains and a significant decrease of in vitro toxicity. The formulation improved the se- lectivity index 2 times in vitro and proved to be 3 times less toxic than the compound alone in the zebrafish embryo acute toxicity test. Hence, the use of this strategy to deliver natural products in Plasmodium-infected cells, particularly those with a narrow therapeutic margin, is proposed. [less ▲]

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See detailAntipromastigote and cytotoxic activities of some chemical constituents of Hypericum lanceolatum Lam.
Kowa, Théodora; Tchokouaha, Lauve; Nyemb, Jean-Noël et al

in Journal of Applied Pharmaceutical Science (2020), 10

Phytochemical investigation of the ethanol extract of the stem bark of Hypericum lanceolatum Lam. (Guttifereae) afforded eight known compounds including 2,2ʹ,5,6ʹ-tetrahydroxybenzophenone (1), 5-hydroxy-3 ... [more ▼]

Phytochemical investigation of the ethanol extract of the stem bark of Hypericum lanceolatum Lam. (Guttifereae) afforded eight known compounds including 2,2ʹ,5,6ʹ-tetrahydroxybenzophenone (1), 5-hydroxy-3-methoxyxanthone (2), 3-hydroxy-5-methoxyxanthone (3), betulinic acid (4), hydroquinone (5) 6,7-dihydroxy-1,3-dimethoxyxanthone (6), calophyllumin A (7), and 1,3,5,6-tetrahydroxy-4-prenylxanthone (8). Compound 1 was submitted to acetylation reaction to give 5-acetoxy-2,2ʹ,6ʹ-trihydroxybenzophenone (9), a new hemisynthetic derivative. Compounds 5 and 8 were isolated for the first time from this plant. The structures were established by extensive analysis of their mass spectrometry and nuclear magnetic resonance (NMR) spectroscopic data and comparison with those from the literature. The isolated compounds (1, 2, 4, 5, and 8) and the derivative of benzophenone (9) were tested for their antipromastigote and cytotoxic activities against visceral leishmaniasis parasite Leishmania donovani and macrophage RAW 264.7 cell line, respectively. Compound 9 was the most active with an IC50 value of 6.1 μg/ml, while compounds 1, 2, 4, and 8 were moderately active with IC50 values ranging from 11.4 to 34.8 μg/ml against L. donovani and were not cytotoxic except compound 5 that was very toxic and not active. The findings of the present study suggested that compounds 1, 2, 4, and 8 could be considered as a potential source of therapeutic medicine for the treatment of leishmaniasis. [less ▲]

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See detailPlants used in traditional medicine in the Comoros archipelago: a review
Saive, Matthew ULiege; Frederich, Michel ULiege; Fauconnier, Marie-Laure ULiege

in Biotechnologie, Agronomie, Société et Environnement (2020), 24(2), 117-141

In the Comoros archipelago, as in many places in Africa, traditional medicine is the first reflex people have when it comes to finding a cure. This work illustrates the diversity of remedies found in this ... [more ▼]

In the Comoros archipelago, as in many places in Africa, traditional medicine is the first reflex people have when it comes to finding a cure. This work illustrates the diversity of remedies found in this group of islands. The plant species potentially effective from a pharmaceutical point of view can be targeted through the comparison of different databases. At the same time, the present study also illustrates the importance of preventing the loss of traditional knowledge based on hundreds of years of observations. Literature: The gathered information in this paper originates from data bases built by ethnobotanists as well as peer reviewed scientific articles. In addition, some information also comes from work done by locals working with recognized organisms. Conclusion: The scientific literature cites 207 different species that are used for traditional practices in the Comoros Archipelago, among which 9 are endemic. These species were compared to the pharmacopoeias of other islands and surroundings from the Indian Ocean in terms of similarities and differences between targeted ailments. Only 3% of the cited species present similarities in use among the islands of the Indian Ocean and surroundings. Most species mentioned in this work have many different uses throughout the Indian Ocean and surroundings. In addition, the importance of defining each physical area of study in a precise way in order to have the most significant results was emphasized. Other important aspects of ethnopharmacology were highlighted, such as the safekeeping of traditional knowledge, as well as the ecological impact an intensive use of some species of interest might cause. Clearly, plants are a rich resource that should be studied and used with an environmentally orientated way of thinking. [less ▲]

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See detailNatural Phenolic Compounds and Derivatives as Potential Antimalarial Agents.
Coelho Cristino Mamede, Lúcia Cristina ULiege; Ledoux, Allison ULiege; Jansen, Olivia ULiege et al

in Planta Medica (2020), 86(9), 585-618

Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the Plasmodium sp ... [more ▼]

Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the Plasmodium sp., has a highly variable antigenicity, which accounts for the emergence and spread of resistance to all available treatments. In light of this rising problem, scientists have turned to naturally occurring compounds obtained from plants recurrently used in traditional medicine in endemic areas. Ethnopharmacological approaches seem to be helpful in selecting the most interesting plants for the search of new antiplasmodial and antimalarial molecules. However, this search for new antimalarials is complex and time-consuming and ultimately leads to a great number of interesting compounds with a lack of discussion of their characteristics. This review aims to examine the most promising antiplasmodial phenolic compounds (phenolic acids, flavonoids, xanthones, coumarins, lignans, among others) and derivatives isolated over the course of the last 28 y (1990 - 2018) and discuss their structure-activity relationships, mechanisms of action, toxicity, new perspectives they could add to the fight against malaria, and finally, the difficulties of transforming these potential compounds into new antimalarials. [less ▲]

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See detailLes déterminants de l’accès à des médicaments antipaludiques de qualité en territoires périurbains africains : résultats d’une enquête menée à Kinshasa (Congo)
Mavungu Landu, Don Jethro ULiege; Marini Djang'Eing'A, Roland ULiege; Hubert, Philippe ULiege et al

in Journal d’Épidémiologie et de Santé publique (2020), 21

Contexte : A Kinshasa, l’indisponibilité des antipaludiques dans les établissements de santé a favorisé une forte utilisation de points de vente privés. Cette situation est d’autant plus dramatique en ... [more ▼]

Contexte : A Kinshasa, l’indisponibilité des antipaludiques dans les établissements de santé a favorisé une forte utilisation de points de vente privés. Cette situation est d’autant plus dramatique en territoires périurbains où la prévalence du paludisme est la plus élevée. Objectif : L’objectif de cette étude était de décrire les caractéristiques des territoires périurbains de Kinshasa pouvant conditionner l’accès aux antipaludiques. Matériel et méthodes : Cette étude transversale a été menée durant la période allant de février 2016 à octobre 2018. Les informations liées au secteur pharmaceutique et aux antipaludiques ont été recueillies grâce à des enquêtes auprès des établissements pharmaceutiques et auprès des entités sanitaires et administratives. Résultats : Environ 1% des pharmacies possède une autorisation d’exploitation du Ministère de la Santé. Toutes les zones de santé sont concernées par l’insécurité et les érosions à des degrés différents. Les axes routiersregroupent68,9% de points de vente. Les vendeurs ont soit une formation de Médecin dans 1,6% de cas, soit de Pharmacien dans 2,4% de cas, soit d’Infirmier dans 54,8% de cas. Mais ils n’ont aucune formation médicale, voire même aucune instruction dans 41,2% des cas. Les antipaludiques étaient non conformes en des proportions différentes sur demande de l’acheteur (87,3%), sur conseil du vendeur(70,2%) et sur prescription médicale (42,1%).L’homologation était soit absente (46%), soit en cours de validité (39,5%),soit expirée (14,5%). Conclusion : Toutes ces irrégularités caractérisant les territoires périurbains de Kinshasa ont une incidence négative sur l’accès de ces derniers aux antipaludiques et installent le doute sur leur qualité. Mots clés : Accès, antipaludiques, territoires périurbains, Kinshasa, République Démocratique du Congo. [less ▲]

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See detailSeasonal effect on the chemical composition, insecticidal properties and other biological activities of Zanthoxylum leprieurii Guill. & Perr. essential oils
Tanoh, Amenan Evelyne ULiege; Blanchard Boué, Guy; Nea, Fatimata ULiege et al

in Foods (2020), 9(5), 550

This study focused, for the first time, on the evaluation of the seasonal effect on the chemical composition and biological activities of essential oils hydrodistillated from leaves, trunk bark and fruits ... [more ▼]

This study focused, for the first time, on the evaluation of the seasonal effect on the chemical composition and biological activities of essential oils hydrodistillated from leaves, trunk bark and fruits of Zanthoxylum leprieurii (Z. leprieurii), a traditional medicinal wild plant growing in Côte d’Ivoire. The essential oils were obtained by hydrodistillation from fresh organs of Z. leprieurii growing on the same site over several months using a Clevenger‐type apparatus and analyzed by gas chromatography‐mass spectrometry (GC/MS). Leaf essential oils were dominated by tridecan‐ 2‐one (9.00 ± 0.02–36.80 ± 0.06%), (E)‐β‐ocimene (1.30 ± 0.50–23.57 ± 0.47%), β‐caryophyllene (7.00 ± 1.02–19.85 ± 0.48%), dendrolasin (1.79 ± 0.08–16.40 ± 0.85%) and undecan‐2‐one (1.20 ± 0.03–8.51 ± 0.35%). Fruit essential oils were rich in β‐myrcene (16.40 ± 0.91–48.27 ± 0.26%), citronellol (1.90 ± 0.02–28.24 ± 0.10%) and geranial (5.30 ± 0.53–12.50 ± 0.47%). Tridecan‐2‐one (45.26 ± 0.96–78.80 ± 0.55%), β‐caryophyllene (1.80 ± 0.23–13.20 ± 0.33%), 𝛼‐humulene (4.30 ±1.09–12.73 ± 1.41%) and tridecan‐2‐ol (2.23 ± 0.17–10.10 ± 0.61%) were identified as major components of trunk bark oils. Statistical analyses of essential oil compositions showed that the variability mainly comes from the organs. Indeed, principal component analysis (PCA) and hierarchical cluster analysis (HCA) allowed us to cluster the samples into three groups, each one consisting of one different Z. leprieurii organ, showing that essential oils hydrodistillated from the different organs do not display the same chemical composition. However, significant differences in essential oil compositions for the same organ were highlighted during the studied period, showing the impact of the seasonal effect on essential oil compositions. Biological activities of the produced essential oils were also investigated. Essential oils exhibited high insecticidal activities against Sitophilus granarius, as well as antioxidant, anti‐inflammatory and moderate anti‐plasmodial properties. [less ▲]

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See detailThe Inhibition of NLRP3 Inflammasome and IL-6 Production by Hibiscus noldeae Baker f. Derived Constituents Provides a Link to Its Anti-Inflammatory Therapeutic Potentials
Tomani, Jean Claude Didelot; Kagisha, Vedaste ULiege; Tchinda, Alembert Tiabou et al

in Molecules (2020), 25(20), 4693

The activation of NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome and/or its components is associated with the physio-pathogenesis of many respiratory diseases including asthma ... [more ▼]

The activation of NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome and/or its components is associated with the physio-pathogenesis of many respiratory diseases including asthma, COPD (chronic obstructive pulmonary disease), SARS Cov-2 (severe acute respiratory syndrome coronavirus 2), and in several autoimmune diseases. Hibiscus noldeae Baker f. has been widely reported to be traditionally used in the treatment of different ailments, some of which are of inflammatory background such as asthma, wounds, headache, etc. However, the claims have not been supported by evidence at the molecular and functional levels. Here, we report on the bio-guided fractionation of H. noldeae and assessment of the inhibitory properties of some fractions and purified compounds on NLRP3 inflammasome and Interleukin 6 (IL-6). The activation of the NLRP3 inflammasome was determined by detecting the activity of caspase-1 and the production of Interleukin 1β (IL-1β) in Lipopolysaccharide (LPS) and ATP-stimulated Tamm-Horsfall Protein 1 (THP-1) macrophages, while the production of IL-6 was studied in LPS-stimulated RAW264.7 mouse macrophages. It was observed that hexane and ethyl acetate fractions of the crude extract of the aerial parts of H. noldeae, as well as caffeic acid, isoquercetin, and ER2.4 and ER2.7 fractions revealed significant inhibitory effects on Caspase-1 activities, and on IL-1β and IL-6 production. The ER2.4 and ER2.7 fractions downregulated the production of IL-1β and IL-6, in a similar range as the caspase-1 inhibitor AC-YVAD-CHO and the drug Dexamethasone, both used as controls, respectively. Overall, our work does provide the very first scientific based evidence for Hibiscus noldeae anti-inflammatory effects and widespread use by traditional healers in Rwanda for a variety of ailments. [less ▲]

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See detailA 1H NMR-based metabolomic approach to study the production of antimalarial compounds from Psiadia arguta leaves (pers.) voigt
Mahadeo, Keshika; Grondin, Isabelle; Herbette, Gaëtan et al

in Phytochemistry (2020), 176

Psiadia arguta (Asteraceae) is endemic to the island of Mauritius in the Indian Ocean. The species is traditionally used to treat various ailments, such as its use as an expectorant or for the treatment ... [more ▼]

Psiadia arguta (Asteraceae) is endemic to the island of Mauritius in the Indian Ocean. The species is traditionally used to treat various ailments, such as its use as an expectorant or for the treatment of bronchitis and asthma. Preliminary biological screenings have displayed the antimalarial (Plasmodium falciparum) and anticancer (HeLa human cell line) potential of P. arguta leaves. The phytochemical investigation of this plant has led to the isolation and characterization of sixteen compounds including five antiplasmodial molecules. The accumulation of the antiplasmodial compounds during the growth of the plant was studied by a 1H NMR-based metabolomic approach. In order to identify factors influencing the production of bioactive compounds, young plants of P. arguta were multiplied using in vitro culture techniques, and micro-propagated plants at different stages of development were acclimatized and followed for the experiments. The multivariate data analysis showed an accumulation of four bioactive compounds in the leaves of P. arguta when these plants were challenged with a biotic stress: labdan-13(E)-en-8α-ol-15-yl acetate, labdan-8α-ol-15-yl acetate, labdan-13(E)-ene-8α-ol-15-diol, and (8R,13S)-labdan-8,15-diol. [less ▲]

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See detailQuality of antimalarials in Kinshasa peri-urban areas with regard to local pharmaceutical legislation and regulation
Mavungu Landu, Don Jethro ULiege; Frederich, Michel ULiege; Manzambi Kuwekita, Joseph et al

in International Health (2020)

Background: In the context of old pharmaceutical legislation and regulations not adapted to current realities, the aim of the present studywas to evaluate the existing pharmaceutical system in peri-urban ... [more ▼]

Background: In the context of old pharmaceutical legislation and regulations not adapted to current realities, the aim of the present studywas to evaluate the existing pharmaceutical system in peri-urban areas of Kinshasa. Methods: A prospective study was carried out during the period 2016–2018. The most used antimalarial medicines were identified through household and pharmaceutical establishment surveys. The samples of the obtained medicines were assayed with generic separation methods using the high-performance liquid chromatography technique coupled to a diode array detector. The registration status was checked for 126 antimalarial brand names. A characterization was carried out in 196 pharmaceutical establishments on the basis of standards set out by the Ministry of Health. Results: Of the 75 samples assayed, 19% (14/75)were non-compliant. Of the 124 brand names, 46.0% (57/124) were unlicensed and 14.5% (18/124) had an expired licence. Of the 196 pharmaceutical establishments, only 2 (1.0%) had an authorization to practice, none met all the Ministry of Health minimum standards and 24.5% (48/196) met the World Health Organization Guidelines for the Storage of Essential Medicines and Other Health Commodities. Conclusions: More resources should be mobilized to apply regulator sanctions. [less ▲]

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See detailEthnopharmacology and antimalarial compounds from tropical plants
Frederich, Michel ULiege

Conference (2019, December 06)

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See detailTotal synthesis approach: development of new antimalarial compounds.
Degotte, Gilles ULiege; Pirotte, Bernard ULiege; Frederich, Michel ULiege et al

Poster (2019, November 22)

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See detailPharmacomodulation of ellagic acid: a total synthesis approach.
Degotte, Gilles ULiege; Pirotte, Bernard ULiege; Frederich, Michel ULiege et al

Poster (2019, September 05)

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See detailChemical composition, in vitro antioxidant and antiparasitic properties of the essential oils of three plants used in traditional medicine in Benin.
Kpadonou, Didier; Kpoviessi, Salomé; Bero, Joanne et al

in Journal of Medicinal Plant Research (2019), 13(6), 384-395

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See detailDesign of new antimalarials inspired by ellagic acid through a total synthesis approach.
Degotte, Gilles ULiege; Halleux, Annabelle; Pirotte, Bernard ULiege et al

Poster (2019, May)

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See detailAntiplasmodial activity of polyphenolic derivatives.
Degotte, Gilles ULiege; Alson, Sylvain; Hans, Aurore et al

in Pharmaceuticals (2019)

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