Publications of Hélène Amory
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See detailComparison of Fecal Microbiota of Horses Suffering from Atypical Myopathy and Healthy Co-Grazers
Wimmer-Scherr, Christina ULiege; Taminiau, Bernard ULiege; Renaud, Benoît ULiege et al

in Animals MPDI (2021), 11(506),

Equine atypical myopathy (AM) is caused by hypoglycin A (HGA) and methylenecyclopropylglycine (MCPG) intoxication resulting from the ingestion of seeds or seedlings of some Acer tree species ... [more ▼]

Equine atypical myopathy (AM) is caused by hypoglycin A (HGA) and methylenecyclopropylglycine (MCPG) intoxication resulting from the ingestion of seeds or seedlings of some Acer tree species. Interestingly, not all horses pasturing in the same toxic environment develop signs of the disease. In other species, it has been shown that the intestinal microbiota has an impact on digestion, metabolism, immune stimulation and protection from disease. The objective of this study was to characterize and compare fecal microbiota of horses suffering from AM and healthy co-grazers. Furthermore, potential differences in fecal microbiota regarding the outcome of diseased animals were assessed. This prospective observational study included 59 horses with AM (29 survivors and 30 nonsurvivors) referred to three Belgian equine hospitals and 26 clinically healthy co-grazers simultaneously sharing contaminated pastures during spring and autumn outbreak periods. Fresh fecal samples (rectal or within 30min of defecation) were obtained from all horses and bacterial taxonomy profiling obtained by 16S amplicon sequencing was used to identify differentially distributed bacterial taxa between AM-affected horses and healthy co-grazers. Fecal microbial diversity and evenness were significantly (p < 0.001) higher in AM-affected horses as compared with their non-affected co-grazers. The relative abundance of families Ruminococcaceae, Christensenellaceae and Akkermansiaceae were higher (p ≤ 0.001) whereas those of the Lachnospiraceae (p = 0.0053), Bacteroidales (p < 0.0001) and Clostridiales (p = 0.0402) were lower in horses with AM, especially in those with a poor prognosis. While significant shifts were observed, it is still unclear whether they result from the disease or might be involved in the onset of disease pathogenesis. [less ▲]

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See detailTwo-dimensional speckle tracking echocardiography in goats: Repeatability, variability, and validation of the technique using an exercise test and an experimentally induced acute ischemic cardiomyopathy
Leroux, A. A.; Moonen, Marie ULiege; Farnir, Frédéric ULiege et al

in BMC Veterinary Research (2020), 16(1),

Background: Two-dimensional speckle tracking (2DST) technique has been validated in numerous animal species, but neither studies of repeatability nor measurements after exercise or in animals with cardiac ... [more ▼]

Background: Two-dimensional speckle tracking (2DST) technique has been validated in numerous animal species, but neither studies of repeatability nor measurements after exercise or in animals with cardiac disease have been reported in goats. Goats are an attractive candidate for animal models in human cardiology because they are easy to handle and have a body and heart size comparable to that of humans. Therefore, the aim of this study was to validate this technique in goats for further clinical and experimental applications in this species. Results: This study was divided into several steps. First, a standardized echocardiographic protocol was performed and 5 cineloops of a right parasternal short-axis view at papillary muscles level were recorded three times at one-day intervals in ten healthy adult unsedated Saanen goats to test repeatability and variability of 2DST measurements. Then, the same measurements were performed immediately before and after a standardized exercise on treadmill in seven of the goats, and at 24 h after induction of an experimental ischemic cardiomyopathy in five of the goats, to test the reliability of the technique to assess physiological and pathological changes. Average and regional measurements of radial and circumferential strain and strain rate, radial displacement, rotation and rotation rate were obtained. Comparisons were performed using two-way ANOVA (p < 0.05). Caprine 2DST average measurements have demonstrated a good repeatability with a low to moderate variability for all measurements except for the diastolic peaks of the circumferential strain rate, radial strain rate and rotation rate. Segmental 2DST measurements were less repeatable than average measurements. Time effect of two-way ANOVA was significant for anteroseptal segment diastolic peaks measurements, rotation and rotation rate measurements. Overall variability of segmental measurements was moderate or high. Segmental and average peak values obtained after exercise and after myocardial ischemia were significantly different than curves obtained at baseline. Conclusions: The results of this study are consistent with those previously described in other animal species and humans. 2DST echocardiography is a valid technique to evaluate physiological and pathological changes in myocardial function in goats, despite the technical limitations observed in this species. © 2020 The Author(s). [less ▲]

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See detailEffect of oral administration of omeprazole on the microbiota of the gastric glandular mucosa and feces of healthy horses
Cerri, Simona; Taminiau, Bernard ULiege; Haché-Carré de Lusancay, Alexandra et al

in Journal of Veterinary Internal Medicine (2020), 34

Background Proton pump inhibitors, such as omeprazole, are used extensively in both human and veterinary patients for treatment and prevention of gastric ulcer syndrome. In human and companion animal ... [more ▼]

Background Proton pump inhibitors, such as omeprazole, are used extensively in both human and veterinary patients for treatment and prevention of gastric ulcer syndrome. In human and companion animal medicine, omeprazole administration has been associated to shifts in gastric and fecal microbiota and increased incidence of Clostridioides difficile enterocolitis, especially in prolonged treatments. Hypothesis/Objectives The purpose of this study was to assess the effect of omeprazole on gastric glandular and fecal microbiota in healthy adult horses. Animals Eight healthy research horses stabled on straw and fed 100% haylage. Methods Prospective controlled study. Transendoscopic gastric glandular biopsies and gastric fluid as well as fresh fecal samples were obtained from each horse at a 7-day interval without treatment to serve as controls. Samples were taken on the same horses before and after a 7-day treatment with omeprazole (4mg/kg PO q24h). Fluid pH was immediately assessed and the rest of samples were kept frozen at -20°C until analysis. Bacterial taxonomy profiling was obtained by V1V3 16S amplicon sequencing from feces and gastric glandular biopsies. Analysis of alpha, beta diversity and comparison between time points were performed with MOTHUR and results were considered significant when p<0.05. Results Significant structural diversity in the microbiota was found in the glandular gastric samples after 7 days of omeprazole administration. No significant differences were found in composition and diversity of fecal microbiota. Conclusions and clinical importance A short course of oral omeprazole does not modify fecal microbiota in healthy horses but modifies the structure of gastric glandular microbiota [less ▲]

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See detailComparison of faecal microbiota of horses suffering from atypical myopathy and healthy co-grazers
Cerri, Simona ULiege; Taminiau, Bernard ULiege; Votion, Dominique ULiege et al

Poster (2017, November 02)

Objectives: To characterize faecal microbiota of horses with atypical myopathy (AM) compared with healthy co-grazers (HcG). Methods: Fresh faecal samples were obtained from 6 horses (1 stallion, 3 ... [more ▼]

Objectives: To characterize faecal microbiota of horses with atypical myopathy (AM) compared with healthy co-grazers (HcG). Methods: Fresh faecal samples were obtained from 6 horses (1 stallion, 3 geldings and 2 females; mean age of 11.810 years) with confirmed AM and 6 HcG (4 geldings and 2 females; mean age of 13.68 years) during autumn-2016 and spring-2017 AM outbreaks in Belgium. Bacterial taxonomy profiling obtained by 16S amplicon sequencing of faeces was used to identify differentially distributed bacterial taxa between AM and HcG. Results were statistically compared using Welch's t-test with STAMP software. Results: A total of 90,407 sequences were analysed and clustered to 8,066 operational taxonomic units. Bacterial populations were distributed between 17 phylas, although 20% of sequences could not be attributed to an existing phylum. Horses with AM harboured a significantly higher relative abundance of Ruminococcaeae family with a significantly lower Lachnospiraceae when compared to HcG. Discussion: AM is caused by hypoglycin A intoxication, but only a part of horses pasturing in the same toxic environment develops the pathology, suggesting that there may be protective factors at the horse level. The results of this study show significant differences in faecal microbiota between AM cases and HcG, which could suggest that microbiota could play a role in the development or prevention of clinical disease. Conclusions: Results demonstrate that microbiota of AM affected horses is significantly different compared to HcG. Significance: Microbiome could influence the development of AM, but this role deserves further investigation. [less ▲]

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See detailRetrospective evaluation of 155 adult equids and 21 foals with tetanus from Western, Northern, and Central Europe (2000-2014). Part 2: Prognostic assessment.
Van Galen, Gaby ULiege; Rijckaert, Joke; Mair, Tim et al

in Journal of Veterinary Emergency and Critical Care (2017)

OBJECTIVE: To identify prognostic variables for adult equids and foals with tetanus. DESIGN: Multicenter retrospective study (2000-2014). SETTING: Twenty Western, Northern, and Central European university ... [more ▼]

OBJECTIVE: To identify prognostic variables for adult equids and foals with tetanus. DESIGN: Multicenter retrospective study (2000-2014). SETTING: Twenty Western, Northern, and Central European university teaching hospitals and private referral centers. ANIMALS: One hundred fifty-five adult equids and 21 foals with tetanus. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Variables from history and clinical examination were statistically compared between survivors and nonsurvivors (adults: 49 survivors, 85 nonsurvivors; foals: 7 survivors, 10 nonsurvivors). Cases euthanized for financial reasons were excluded. Mortality rates in adults and foals were 68.4% and 66.7%, respectively. Variables associated with survival in adults included: standing, normal intestinal sounds and defecation, voluntarily drinking, eating soft or normal food, lower heart and respiratory rates, high base excess on admission, longer diagnosis time, treatment and hospitalization delay, and mild severity grade. Variables associated with death included: anorexia, dysphagia, dyspnea, low blood potassium concentration on admission, moderate and severe disease grading, development of dysphagia, dyspnea, recumbency and seizures during hospitalization, treatment with glycerol guaiacolate, intravenous fluids, and intravenous glucose solutions. Variables associated with survival in foals included standing on admission, voluntarily eating soft food and drinking, older age, and longer hospitalization delay. Outcome was not different between different tetanus antitoxin (TAT) dosages, although there was a trend of increasing survival rate with increasing TAT dosages. Cases with appropriate vaccination prior to development of tetanus were rare, but had improved outcome and shorter hospitalization. CONCLUSIONS: Prognosis for equine tetanus is poor with similar outcome and prognostic factors in foals and adults. The prognostic assessment of cases with tetanus provides clinicians with new evidence-based information related to patient management. Several prognostic indicators relate to the ability to eat or drink, and more severe clinical signs relate to poor outcome. Increasing intravenous dosages of TAT has no significant effect on outcome, but the positive trend identified may support a recommendation for high intravenous TAT dosages. Further evaluation is warranted. [less ▲]

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See detailRetrospective evaluation of 155 adult equids and 21 foals with tetanus in Western, Northern, and Central Europe (2000-2014). Part 1: Description of history and clinical evolution.
Van Galen, Gaby ULiege; Saegerman, Claude ULiege; Rijckaert, Joke et al

in Journal of Veterinary Emergency and Critical Care (2017)

OBJECTIVE: To describe clinical data of hospitalized adult equids and foals with tetanus. DESIGN: Multicenter retrospective study (2000-2014). SETTING: Twenty Western, Northern, and Central European ... [more ▼]

OBJECTIVE: To describe clinical data of hospitalized adult equids and foals with tetanus. DESIGN: Multicenter retrospective study (2000-2014). SETTING: Twenty Western, Northern, and Central European university teaching hospitals and private referral centers. ANIMALS: One hundred fifty-five adult equids (>6 months) and 21 foals (<6 months) with tetanus. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Information on geographic, annual and seasonal data, demographic- and management-related data, clinical history, clinical examination and blood analysis on admission, complications, treatments, and outcomes were described and statistically compared between adults and foals. The described cases were often young horses. In 4 adult horses, tetanus developed despite appropriate vaccination and in 2 foals despite preventive tetanus antitoxin administration at birth. Castration, hoof abscesses, and wounds were the most common entry sites for adults; umbilical cord infections and wounds for foals. Stiffness was the commonest observed initial clinical sign. Blood analyses frequently revealed an inflammatory response, hemoconcentration, muscle damage, azotemia, negative energy balance, liver damage, and electrolyte and acid base disturbances. Common complications or clinical signs developing during hospitalization included dysphagia, dyspnea, recumbency, hyperthermia, seizures, hyperlipemia, gastrointestinal impactions, dysuria, and laryngeal spasms. Cases were supported with wound debridement, antimicrobial treatment, tetanus antitoxin, muscle spasm and seizure control, analgesia, anti-inflammatory drugs, fluid therapy, and nutritional support. Mortality rates were 68.4% in adult horses and 66.7% in foals. Foals differed from adult horses with respect to months of occurrence, signalment, management-related data, potential causative events, clinical signs on admission, blood analysis, complications, and severity grades. CONCLUSIONS: This is the first study that rigorously describes a large population of equids affected by tetanus. The information provided is potentially useful to clinicians for early recognition and case management of tetanus in adult horses and foals. Tetanus affects multiple organ systems, requiring broad supportive and intensive care. Neonatal and adult tetanus in the horse should be considered as distinct syndromes, as in human medicine. [less ▲]

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See detailSeroprevalence of Borrelia burgdorferi in horses in the southern part of Belgium: a “one health” driven study
Meersschaert, Carole ULiege; Cerri, Simona ULiege; Houben rosa, Rosa et al

Conference (2016, September 08)

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See detailPrevalence of respiratory pathogens in nasal swabs from horses with acute respiratory disease in Belgium
Broux, Barbara; Gryspeerdt, Annick; Amory, Hélène ULiege et al

in Vlaams Dierengeneeskundig Tijdschrift (2016), 85

Contagious respiratory infections are an important cause of respiratory disease in horses, resulting in impaired pulmonary function, poor performance and sometimes severe illness. Although bacterial ... [more ▼]

Contagious respiratory infections are an important cause of respiratory disease in horses, resulting in impaired pulmonary function, poor performance and sometimes severe illness. Although bacterial infections are often suspected to be involved, viruses are frequently overlooked and are an underestimated cause of respiratory disease outbreaks in horses. In this study, nasal swabs of 103 horses with acute symptoms of respiratory disease were analyzed for the presence of 13 different respiratory pathogens. Gamma herpesviruses were the most commonly detected, with 60% of the samples being positive, followed by streptococcus equi subsp. zooepidemicus infection (30%). Rhinovirus B, streptococcus equi subsp. equi, adenovirus 1 and EHV-4 were more rarely detected. Further research is necessary to correctly interpret the importance of gamma herpesviruses in horses, for example by screening a healthy control population. National surveillance of respiratory viruses in horses by PCR analysis on nasal swabs might be a useful, earlywarning system for viral epidemics. [less ▲]

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See detailFaecal microbiota characterisation of horses using 16 rdna barcoded pyrosequencing, and carriage rate of clostridium difficile at hospital admission
Rodriguez Diaz, Cristina ULiege; Taminiau, Bernard ULiege; Brévers, Bastien et al

in BMC Microbiology (2015), 15

Background The equine faecal microbiota is very complex and remains largely unknown, while interspecies interactions have an important contribution to animal health. Clostridium difficile has been ... [more ▼]

Background The equine faecal microbiota is very complex and remains largely unknown, while interspecies interactions have an important contribution to animal health. Clostridium difficile has been identified as an important cause of diarrhoea in horses. This study provides further information on the nature of the bacterial communities present in horses developing an episode of diarrhoea. The prevalence of C. difficile in hospitalised horses at the time of admission is also reported. Results Bacterial diversity of the gut microbiota in diarrhoea is lower than that in non-diarrhoeic horses in terms of species richness (p-value <0.002) and in population evenness (p-value: 0.02). Statistical differences for Actinobacillus, Porphyromonas, RC9 group, Roseburia and Ruminococcaceae were revealed. Fusobacteria was found in horses with diarrhoea but not in any of the horses with non-diarrheic faeces. In contrast, Akkermansia was among the three predominant taxa in all of the horses studied. The overall prevalence of C. difficile in the total samples of hospitalised horses at admission was 3.7 % (5/134), with five different PCR-ribotypes identified, including PCR-ribotype 014. Two colonised horses displayed a decreased bacterial species richness compared to the remaining subjects studied, which shared the same Bacteroides genus. However, none of the positive animals had diarrhoea at the moment of sampling. Conclusions The abundance of some taxa in the faecal microbiota of diarrhoeic horses can be a result of microbiome dysbiosis, and therefore a cause of intestinal disease, or some of these taxa may act as equine enteric pathogens. Clostridium difficile colonisation seems to be transient in all of the horses studied, without overgrowth to trigger infection. A large proportion of the sequences were unclassified, showing the complexity of horses’ faecal microbiota. [less ▲]

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See detailTWO-DIMENSIONAL SPECKLE TRACKING ECHOCARDIOGRAPHY IN CALVES: FEASIBILITY, REPEATABILITY AND VARIABILITY STUDY
Lecoq, Laureline ULiege; Amory, Hélène ULiege; Leroux, Aurélia ULiege

in Journal of Veterinary Internal Medicine (2015), 29(4), 1255

Two-dimensional speckle tracking (2DST) is a non-invasive technique used in many species to evaluate global and regional left ventricular (LV) function; however it received little attention in the bovine ... [more ▼]

Two-dimensional speckle tracking (2DST) is a non-invasive technique used in many species to evaluate global and regional left ventricular (LV) function; however it received little attention in the bovine species. The aim of this study was to assess the feasibility and reliability of 2DST for the evaluation of circumferential and radial LV wall motions in calves. Fourteen Holstein black calves (age: 62 11.6 days; body weight: 75.25 5.4 kg) were used in this observational study. Right parasternal short axis views at the level of the papillary muscles were recorded and subsequently analysed by 2DST for global and regional radial and circumferential strains and strain rates, radial displacement, rotation and rotation rate. Echocardiographic examinations were performed in unsedated, standing calves by two different observers to evaluate intra- and interobserver repeatability and variability. 2DST was feasible in all calves but 2 were excluded from analyses (ventricular septum defect and resting heart rate above 120 bpm, respectively). Automated tracking was better in systole than in diastole. Intraobserver repeatability was good to moderate for most systolic global and segmental peak values. Systolic peak values for radial strain and strain rate were more repeatable than for circumferential strain, circumferential train rate and diastolic measurements. Variability of the interobserver measurements was greater than the intraobserver measurements. Two-dimensional speckle tracking is feasible in calves and as in other species systolic radial function can be more reliably evaluated than circumferential and diastolic function. [less ▲]

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See detailEVALUATION OF THE CARDIOMYOTOXIC EFFECTS OF DOXYCYCLINE OVERDOSE IN CALVES USING 2-DIMENSIONAL SPECKLE TRACKING.
Lecoq, Laureline ULiege; Leroux, Aurélia ULiege; Brihoum, Mounir et al

in Journal of Veterinary Internal Medicine (2015), 29(4), 1254

Doxycycline (DOXY) is associated with left ventricular (LV) dysfunction in calves in accidental overdose but not in experimental models when evaluated with classical and Doppler echocardiography. Two ... [more ▼]

Doxycycline (DOXY) is associated with left ventricular (LV) dysfunction in calves in accidental overdose but not in experimental models when evaluated with classical and Doppler echocardiography. Two-dimensional-speckle tracking (2DST) is used to evaluate LV dysfunction in numerous species but not in cattle. The aim of this study was to evaluate the cardiotoxic effects of an experimental overdose of DOXY using 2DST in calves. Ten healthy male Holstein calves. Group 1: 5 calves (mean age 58.0 +/- 16.3 days; mean body weight 72.2 +/- 13.0 kg) received 25 mg/kg of DOXY orally for 5 days. Group 2: 5 calves (mean age 56.4 +/- 15.7 days; mean body weight 73.4 +/- 7.0 kg) received a placebo. Electrocardiography (ECG) and 2DST echocardiography were performed at day 0 and day 8. ECG tracings were analysed for occurrence of arrhythmias. 2DST measurements included global and segmental, peak values for radial and circumferential strains (SR, SC), strain rates (SrR, SrC), rotation (Rot), rotation rates (RotR) and radial displacement (DR). All calves completed the study. ECG recordings were unremarkable in both groups. Heart rate was neither significantly different between groups nor before and after treatment. LV systolic function was affected in calves receiving an overdose of DOXY as shown by a significant decrease of segmental SR (P < 0.05), SC (P < 0.05) and DR (P < 0.05) in treated calves compared to the placebo group in several segments. The SrC in early diastole was also significantly decreased in 1 segment (<0.05). In calves, DOXY overdose induces a LV dysfunction in systole, and to a lesser extent, in diastole. A better comprehension of the pathophysiology involved in the DOXY overdose will help in the treatment of accidental cases. [less ▲]

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See detailBorréliose: mythe ou réalité ?
Amory, Hélène ULiege; Houben, Rosa ULiege; Pitel, Pierre-Hugues et al

Conference (2014, November 15)

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See detailPrognostic value of echocardiographic and Doppler parameters in horses admitted for colic complicated by systemic inflammatory response syndrome
Borde, L.; Amory, Hélène ULiege; Grulke, Sigrid ULiege et al

in Journal of Veterinary Emergency and Critical Care (2014), 24(3), 302-310

Objective: To assess the prognostic value of echocardiographic parameters of left ventricular (LV) function in horses with systemic inflammatory response syndrome (SIRS). Design: Prospective observational ... [more ▼]

Objective: To assess the prognostic value of echocardiographic parameters of left ventricular (LV) function in horses with systemic inflammatory response syndrome (SIRS). Design: Prospective observational study. Setting: Veterinary teaching hospital. Animals: Forty-one horses admitted for colic with clinical evidence of SIRS. Interventions: All horses underwent Doppler echocardiographic examination on admission. LV echocardiographic parameters, including pulsed-wave tissue Doppler imaging parameters, were compared between nonsurvivors (n = 29) and horses that survived to discharge (n = 12). Measurements and Main Results: With comparable heart rate and LV preload estimate, LV stroke volume index, the velocity time integral, deceleration time, ejection time of Doppler aortic flow, and peak early diastolic myocardial velocity were lower in the nonsurviving than in the surviving horses, while pre-ejection period to ejection time ratio (PEP/ET) of Doppler aortic flow and the peak early diastolic filling velocity to peak early diastolic myocardial velocity ratio (E/Em) were higher (P < 0.05). A cut-off value of 0.26 for PEP/ET predicted mortality with 100% sensitivity and 42% specificity (area under the receiver operating characteristic curve: 0.71), whereas a cut-off value of 2.67 for E/Em predicted mortality with 100% sensitivity and 83% specificity (area under the receiver operating characteristic curve: 0.89). Conclusions: Echocardiography may provide prognostic information in colic horses with clinical evidence of SIRS. Especially, PEP/ET and E/Em could be useful markers of systolic and diastolic dysfunction, respectively, to detect horses with a high risk of death requiring more intensive cardiovascular monitoring as it has been reported in human patients with septic shock. © Veterinary Emergency and Critical Care Society 2014. [less ▲]

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See detailL’insuffisance mitrale chez le cheval : revue de la littérature et comparaison avec la pathologie chez l’homme et chez le chien
Al Haidar, Ali; Leroux, Aurélia ULiege; Amory, Hélène ULiege

in Annales de Médecine Vétérinaire (2013), 157(1), 52-68

Abstract Mitral regurgitation (MR) is a one of the most common cardiac disease in the equine species. Furthermore, it is the valvular disease that presents the higher risk to be associated with reduced ... [more ▼]

Abstract Mitral regurgitation (MR) is a one of the most common cardiac disease in the equine species. Furthermore, it is the valvular disease that presents the higher risk to be associated with reduced athletic performance, to evolve into congestive heart failure and to become life threatening. The clinical diagnosis of MR depends mainly on the expertise of the veterinarian in cardiology and is above all based on cardiac auscultation. In all of the cases, the definitive diagnosis and the evaluation of the disease severity require performing a Doppler echocardiographic examination. Signs of left ventricular and/or left atrial overload, large regurgitation jet, pulmonary arterial hypertension or significant arrhythmias are negative prognosis factors. Clinical signs of congestive heart failure make the prognosis worse. Other echocardiographic parameters are used in human and dogs in order to determine the severity of the MR, but have been not validated in horses. Treatment of mitral regurgitation in the equine species is symptomatic and directed against the development of a congestive heart failure. A lot of drugs that are used in human or dogs are of limited value in horses for financial reasons and/or lack of pharmacokinetics and pharmacologic data in equine species. [less ▲]

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See detailLa vermifugation régulière systématique des chevaux est-elle vraiment nécessaire ?
Caron, Yannick ULiege; Borde, L; Losson, Bertrand ULiege et al

in Veterinaria: Bulletin d'Information de l'Union Syndicale Vétérinaire Belge (2013)

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See detailRepeatability, variability and reference values of pulsed wave Doppler echocardiographic measurements in healthy Saanen goats.
Leroux, Aurélia ULiege; Farnir, Frédéric ULiege; Moonen, Marie ULiege et al

in BMC Veterinary Research (2012), 8

Background Pulsed wave (PW) Doppler echocardiography has become a routine non invasive cardiac diagnostic tool in most species. However, evaluation of intracardiac blood flow requires reference values ... [more ▼]

Background Pulsed wave (PW) Doppler echocardiography has become a routine non invasive cardiac diagnostic tool in most species. However, evaluation of intracardiac blood flow requires reference values, which are poorly documented in goats. The aim of this study was to test the repeatability, the variability, and to establish the reference values of PW measurements in healthy adult Saanen goats. Using a standardised PW Doppler echocardiographic protocol, 10 healthy adult unsedated female Saanen goats were investigated three times at one day intervals by the same observer. Mitral, tricuspid, aortic and pulmonary flows were measured from a right parasternal view, and mitral and aortic flows were also measured from a left parasternal view. The difference between left and right side measurements and the intra-observer inter-day repeatability were tested and then the reference values of PW Doppler echocardiographic parameters in healthy adult female Saanen goats were established. Results As documented in other species, all caprine PW Doppler parameters demonstrated a poor inter-day repeatability and a moderate variability. Tricuspid and pulmonary flows were best evaluated on the right side whereas mitral and aortic flows were best obtained on the left side, and reference values are reported for healthy adult Saanen goats. Conclusions PW Doppler echocardiography allows the measurement of intracardiac blood flow indices in goats. The reference values establishment will help interpreting these indices of cardiac function in clinical cardiac cases and developing animal models for human cardiology research. [less ▲]

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See detailPeut-on traiter l'insuffisance cardiaque chez le cheval ?
Amory, Hélène ULiege

in In Proceedings of the 39ème journées annuelles de l'Association des Vétérinaires Equins Français (AVEF) (2011, December 05)

L’insuffisance cardiaque congestive (ICC) est définie comme un syndrome clinique dans lequel le cœur devient incapable de pomper une quantité suffisante de sang pour répondre aux besoins métaboliques de ... [more ▼]

L’insuffisance cardiaque congestive (ICC) est définie comme un syndrome clinique dans lequel le cœur devient incapable de pomper une quantité suffisante de sang pour répondre aux besoins métaboliques de l’organisme malgré un retour veineux adéquat. Différentes causes peuvent en être à l’origine, et elles résultent soit en des capacités inotropes diminuées, soit en un remplissage ventriculaire défaillant, ou soit encore en une surcharge volumique ou en pression. Des mécanismes intra- et extra-cardiaques d’adaptation sont mis en place et permettent dans un premier stade de lutter contre la chute du débit cardiaque, mais au-delàs d’une certaine limite tous deviennent délétères pour l’organisme. Le traitement de l’ICC doit être mis en place en tenant compte de ces mécanismes. Chez le cheval, la cause la plus fréquente d’ICC est une pathologie valvulaire entrainant une surcharge volumique. Les principales molécules utilisées pour lutter contre l’ICC dans cette espèce sont le furosémide, la digoxine et les inhibiteurs de l’enzyme de conversion de l’angiotensine. [less ▲]

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See detailQuelle importance accorder à une arythmie lors d'une visite d'achat ?
Amory, Hélène ULiege

in In Proceedings of the 39ème journées annuelles de l'Association des Vétérinaires Equins Français (AVEF) (2011, December 05)

Les arythmies cardiaques sont fréquentes dans l'espèce équine. Cependant, dans la plupart des cas ces arythmies sont physiologiques. Lors d’une visite d’achat, toute la difficulté à laquelle le ... [more ▼]

Les arythmies cardiaques sont fréquentes dans l'espèce équine. Cependant, dans la plupart des cas ces arythmies sont physiologiques. Lors d’une visite d’achat, toute la difficulté à laquelle le vétérinaire sera confronté consistera à différentier de telles arythmies physiologiques d'arythmies pathologiques, qui pourraient avoir un impact sur la carrière future du cheval. Si dans ce cadre l'examen clinique constitue la première étape à réaliser, une électrocardiographie de repos constitue l’étape incontournable pour poser le diagnostic. Dans de nombreux cas, une électrocardiographie d’effort ou sur une durée prolongée (Holter) peut cependant aussi s’avérer nécessaire pour différentier une arythmie physiologique d’une arythmie pathologique. [less ▲]

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See detailTétanos chez le cheval: quand y penser et que faire ?
Amory, Hélène ULiege

in In Proceedings of the 39ème journées annuelles de l'Association des Vétérinaires Equins Français (AVEF) (2011, December 05)

Le tétanos est une maladie causée par les exotoxines produites par la bactérie anaérobie Clostridium tetani. Il présente une répartition mondiale et affecte tous les mammifères, mais l’espèce équine est ... [more ▼]

Le tétanos est une maladie causée par les exotoxines produites par la bactérie anaérobie Clostridium tetani. Il présente une répartition mondiale et affecte tous les mammifères, mais l’espèce équine est l’espèce la plus sensible. Bien que la vaccination a largement contribué à réduire drastiquement le nombre de cas à l’heure actuelle, il n’en reste pas moins utile pour le praticien équin de connaitre les signes cliniques suggestifs de la maladie afin de pouvoir administrer au plus vite du sérum antitétanique. Dans cette conférence, un rappel de l’épidémiologie, du tableau clinique, du diagnostic différentiel et du traitement de cette maladie sera réalisé. [less ▲]

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