Publications of Sophie Delrez
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See detailA prospective audit of acute ENT activity in a university teaching hospital
Atta, Lucas; Delrez, Sophie ULiege; Asimakopoulos, Asimakis et al

in B-ENT (2019), 15

Introduction and aim: Acute ENT coverage is available out-of-hours in most hospitals. However, increasing pressure to reduce healthcare cost threatens this 24-hour availability. Our goal was to audit the ... [more ▼]

Introduction and aim: Acute ENT coverage is available out-of-hours in most hospitals. However, increasing pressure to reduce healthcare cost threatens this 24-hour availability. Our goal was to audit the emergency ENT activity in our institution. Methods: A prospective audit of all ENT emergency referrals was carried out over a one-month period in an academic hospital. Descriptive statistics were produced for age, sex, origin, admission time, diagnosis, management, and patient outcome. Results: A total of 190 patients (109 men and 81 women) were referred to the ENT emergency service over the study period (mean, 6.1 cases/day). Mean age was 47.9 (SD ±23.6) years. Most admissions (76.4%) occurred during normal working hours, and 62.0% of patients were self-referred. The mean complaint duration before admission was 7.6 (±13.7) days. One third (33.2% patients) required ambulatory treatment, a quarter (24.7% patients) had a minor ENT procedure, 18 (9.5%) required admission to the ward, and 8 (4.2%) required surgical treatment. Severity of diagnosis or management between patients did not differ with referral by a physician (GP or specialist) and self-referral. At 30 days, 3 (1.6%) patients died, 106 (55.8%) benefitted from an ENT follow-up, 65 (34.2%) were referred to another physician (GP or specialist), and 16 (8.4%) were lost to follow-up. Conclusions: The results of this workload audit suggest that emergency ENT activity is justified in our hospital. Restricting emergency ENT cover to patients referred by a GP or another physician would not improve patient selection. [less ▲]

Detailed reference viewed: 84 (19 ULiège)
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See detailRhinologic Emergencies: a Prospective Audit in a University Teaching Hospital
ROGISTER, Florence ULiege; ATTA, Lucas; Delrez, Sophie ULiege et al

Conference (2018, April)

Aims: Increasing pressure to reduce healthcare cost threatens the provision of acute ENT coverage round the clock. Our goal was to audit our emergency rhinologic activity over a one-month period. Methods ... [more ▼]

Aims: Increasing pressure to reduce healthcare cost threatens the provision of acute ENT coverage round the clock. Our goal was to audit our emergency rhinologic activity over a one-month period. Methods: A prospective audit for all emergency ENT referrals was carried out from May 1st to May 31th 2017. Descriptive statistics were produced for age, sex, origin, time of arrival, diagnosis and outcome. A specific subgroup analysis was performed for rhinologic emergencies. A basic cost analysis was ran. Results: Over the study period, 190 patients were referred to the ENT emergency service. Twenty percent patients presented with nose or sinus complaint (36.8% with otological or neuro-vestibular primary complaint, 43.2% with laryngeal or neck complaint). Nose and throat complaints were more likely to present at night or on weekends. Ear complaints were more likely to present during business hours. Rhinologic complaint was more likely to require technical or surgical management than ear or throat complaint. Patients with nose complaint required minor procedure in 43.2% cases (35.6% of the total minor procedures), and required surgical procedure in 13.5% cases. Among the total ENT emergency surgical procedures, 62.5% were rhinologic ones, involving the nose (50%) or the sinus (12.5%). Ear or throat initial complaint were more likely to require no treatment or ambulatory management. Conclusion: The emergency rhinologic activity is justified in our hospital. An initial rhinological complaint was more likely to require specific ENT management than other complaints. ENT cover is an efficient service provision, especially for rhinologic emergencies. [less ▲]

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See detailA Prospective Audit of Acute ENT Activity in a Teaching Hospital.
Goffinet, Maxime ULiege; ATTA, Lucas; Delrez, Sophie ULiege et al

in B-ENT (2018, March 03)

Introduction and aim: Acute ENT coverage is available out-of-hours in most hospitals. However, increasing pressure to reduce healthcare cost threatens this service provision round the clock. Our goal was ... [more ▼]

Introduction and aim: Acute ENT coverage is available out-of-hours in most hospitals. However, increasing pressure to reduce healthcare cost threatens this service provision round the clock. Our goal was to audit the emergency ENT activity in our institution over a one-month period Material and methods: a prospective audit for all ENT referrals from the emergency department was carried out from May 1st to May 31th 2017. Descriptive statistics were produced for age, sex, origin, time of arrival, diagnosis and patient outcome. Results: a total of 190 patients (109 men and 81 women) were referred to the ENT emergency service over the study period (mean 6.1 case per day). Mean age was 47.9 (±23.6)year (range 1-95). Most patients were ambulatory (75.8%) and came from the area. Most admissions occurred during normal working hours (76.4%) and 62.0% patients came by self reference. The mean complaint duration before admission was 7.6 (±13.7) days (range 0-92 days). One third (33.2% patients) required ambulatory treatment. A quarter (24.7% patients) underwent a minor ENT procedure. Eighteen (9.5%) patients required admission to the ward (mostly for intravenous antibiotic). Eight patients (4.2%) required surgical treatment. There was no difference in the severity of diagnosis or management between patients referred by a physician (GP of specialist) and patients presenting spontaneously. At 30 days, 3 (1.6%) patients died (one of ENT cancer, two of unrelated cause), 106 (55.8%) benefited from an ENT follow’up, 65 (34.2%) were referred to another physician (GP or specialist), 16 (8.4%) were lost to follow’up. Conclusions: The workload suggests that emergency ENT activity is justified in our hospital. Restricting emergency ENT cover to patients referred by a GP or another physician would not allow for a better patient selection. [less ▲]

Detailed reference viewed: 123 (19 ULiège)
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See detailUnravelling the roles of lysine acetylation by Elp3 during inner ear development
Mateo Sanchez, Susana ULiege; Delacroix, Laurence ULiege; Freeman, Stephen ULiege et al

Poster (2016, January 25)

We planned to investigate the role of Elp3 acetyl-transferase, a member of the Elongator complex, in inner ear formation. We first analysed the spatio-temporal pattern of Elp3 mRNA expression and showed ... [more ▼]

We planned to investigate the role of Elp3 acetyl-transferase, a member of the Elongator complex, in inner ear formation. We first analysed the spatio-temporal pattern of Elp3 mRNA expression and showed that it was expressed in the entire early otocyst at E11.5 and persisted later in the sensory epithelium of the cochlea, in the spiral ganglion and in the vestibule. To unravel functions of Elp3, we used conditional knock-out mice in which Elp3 gene is deleted from early otocyst (Elp3cKO). We submitted these mice to a battery of vestibular testing and found significant abnormalities. Besides, the auditory brain stem response of Elp3cKO indicated that these mice are severely deaf. We were also able to demonstrate an increased level of apoptosis in the Elp3cKO spiral ganglion leading to a reduced number of neurons and fibers innervating the sensory cells as well as a reduced number of their synaptic ribbons. Moreover, the remaining spiral ganglion neurons extend processes showing clearly defects regarding sensory cell innervation. In conclusion, our results clearly show a role for Elp3 both in hearing and balance. We plan to go deeper in the mechanisms involved through the identification of the proteins that are targeted for acetylation by Elp3. [less ▲]

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See detailUNRAVELLING THE ROLES OF LYSINE ACETYLATION BY ELP3 DURING INNER EAR DEVELOPMENT
Mateo Sanchez, Susana ULiege; Delacroix, Laurence ULiege; Freeman, Stephen ULiege et al

Poster (2015, November 23)

We planned to investigate the role of Elp3 acetyl-transferase, a member of the Elongator complex, in inner ear formation. We first analysed the spatio-temporal pattern of Elp3 mRNA expression and showed ... [more ▼]

We planned to investigate the role of Elp3 acetyl-transferase, a member of the Elongator complex, in inner ear formation. We first analysed the spatio-temporal pattern of Elp3 mRNA expression and showed that it was expressed in the entire early otocyst at E11.5 and persisted later in the sensory epithelium of the cochlea, in the spiral ganglion and in the vestibule. To unravel functions of Elp3, we used conditional knock-out mice in which Elp3 gene is deleted from early otocyst (Elp3cKO). We submitted these mice to a battery of vestibular testing and found significant abnormalities. Besides, the auditory brain stem response of Elp3cKO indicated that these mice are severely deaf. We were also able to demonstrate an increased level of apoptosis in the Elp3cKO spiral ganglion leading to a reduced number of neurons and fibers innervating the sensory cells as well as a reduced number of their synaptic ribbons. Moreover, the remaining spiral ganglion neurons extend processes showing clearly defects regarding sensory cell innervation. In conclusion, our results clearly show a role for Elp3 both in hearing and balance. We plan to go deeper in the mechanisms involved through the identification of the proteins that are targeted for acetylation by Elp3. [less ▲]

Detailed reference viewed: 28 (6 ULiège)
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See detailUNRAVELLING THE ROLES OF LYSINE ACETYLATION BY ELP3 DURING INNER EAR DEVELOPMENT
Mateo Sanchez, Susana ULiege; Delacroix, Laurence ULiege; Freeman, Stephen ULiege et al

Poster (2015, June 06)

Given the importance of acetylation homeostasis in controlling developmental processes [1-3], we planned to investigate its role in inner ear formation and focused our attention on Elp3 acetyl-transferase ... [more ▼]

Given the importance of acetylation homeostasis in controlling developmental processes [1-3], we planned to investigate its role in inner ear formation and focused our attention on Elp3 acetyl-transferase, a member of the Elongator complex recently implicated in neurogenesis [4]. To determine the role of Elp3 in the inner ear, we first analysed the spatio-temporal pattern of ELp3 mRNA expression and showed that it was expressed in the entire early otocyst at E11.5 and persisted later in the sensory epithelium of the cochlea (the organ of Corti), in the spiral ganglion, in the stria vascularis and in the vestibule. To unravel in vivo functions of Elp3 in the inner ear, we used conditional knock-out mice in which Elp3 gene is deleted from early otocyst (Elp3 cKO). We submitted these mice to a battery of vestibular testing (i.e. stereotyped circling ambulation, head bobbing, retropulsion, and absence of reaching response in the tail-hanging test) and found significant abnormalities. Besides, the auditory brain stem response of Elp3 cKO indicated that these mice are severely deaf. At the cellular level, we did not find any structural abnormalities nor cell patterning defects that could explain deafness or balance dysfunction in Elp3 cKO mice. However, we detected some defaults in the planar orientation of their auditory hair cell bundle. We were also able to demonstrate an increased level of apoptosis in the Elp3 cKO spiral ganglion at E14.5 leading to a reduced number of neurons and fibers innervating the cochlear hair cells as well as a reduced number of their synaptic ribbons at P15. Moreover, the remaining spiral ganglion neurons extend processes showing clearly defects regarding hair cells innervation (misorientation of fibers). In conclusion, our results clearly show a role for Elp3 both in hearing and balance. We plan to go deeper in the mechanisms involved through the identification of the proteins that are targeted for acetylation by Elp3. [less ▲]

Detailed reference viewed: 47 (15 ULiège)