Publications of Claire Geurten
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See detailMethotrexate-induced Acute Myelopathy in a Teenager With High-risk Acute Lymphoblastic Leukemia
Geurten, Claire ULiege; FORGET, Patricia ULiege; LEROY, Patricia ULiege et al

in Journal of Pediatric Hematology/Oncology (2018)

Acute lymphoblastic leukemia (ALL) is one of the most frequent malignancies in childhood whose long-term survival has increased up to 80% thanks to modern therapy enhancements. Nevertheless, methotrexate ... [more ▼]

Acute lymphoblastic leukemia (ALL) is one of the most frequent malignancies in childhood whose long-term survival has increased up to 80% thanks to modern therapy enhancements. Nevertheless, methotrexate (MTX) remains a mainstay of ALL therapy, but also represents one of the major causes of neurotoxicity in patients with ALL. MTX-induced toxicity occurs in about 9% of patients treated for ALL. It usually affects deep white matter region leading to leukoencephalopathy, which has varying clinical manifestations ranging from acute neurological disturbances to seizures or chronic permanent encephalopathy. Here we describe a 13-year-old girl affected with ALL who developed lower limbs hypesthesia and static ataxia due to transverse myelopathy after intrathecal administration of MTX therapy. A high-dose corticotherapy combined to vitamin supplementation and rehabilitation was tested. Neurological evolution was characterized by slow and partial recovery. [less ▲]

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See detailAtteintes osseuses des leucemies lymphoblastiques aigues pediatriques : experience monocentrique et revue de la litterature.
Pécheux, Lucie ULiege; FORGET, Patricia ULiege; Geurten, Claire ULiege et al

in Revue Médicale de Liège (2018), 73(11), 575-582

Bone pain associated with bone marrow infiltration is often present at diagnosis of pediatric acute lymphoblastic leukemia (ALL). It sometimes signs the presence of pathological fracture, lytic lesions ... [more ▼]

Bone pain associated with bone marrow infiltration is often present at diagnosis of pediatric acute lymphoblastic leukemia (ALL). It sometimes signs the presence of pathological fracture, lytic lesions, arthritis, or osteitis associated to ALL that can delay the diagnosis. During treatment, bone complications (pain, osteopenia, fracture, avascular necrosis, ...) are also reported. In order to describe bone involvement (BI) of pediatric LLA, we reviewed the records of 104 patients followed in our unit. The overall incidence of BI was 67 %. At diagnosis, 50 % of patients had BI and in 19 %, the diagnosis of ALL was delayed. During and after treatment, respectively 28 % and 37 % of patients presented bone complications (pain, fractures, avascular necrosis, osteopenia). Patients with BI had a lower leukocytosis inferior to 10x109/l (p = 0.005) and an ALL of average risk (p = 0.019). 38 % of patients with BI during treatment were over 10 years old and 55 % were girls (vs. 21 % and 38 % in the entire cohort, respectively). Osteoporosis was more severe at diagnosis than during treatment, suggesting the presence of constitutional promoting factors. In our cohort, the majority of BI was resolved at the end of treatment with no long-term sequelae. [less ▲]

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See detailMTHFR polymorphisms and susceptibility to Methotrexate toxicity : a literature review.
Geurten, Claire ULiege; Hoyoux, Claire

Poster (2018)

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See detailPseudotumoral cerebellitis with acute hydrocephalus as a manifestation of EBV infection
Geurten, Claire ULiege; de Bilderling, Georges; Nassogne, M-C et al

in Revue Neurologique (2018)

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See detailQuand l’insuffisance cardiaque se cache derrière la bronchiolite.
de Bilderling, Georges; Geurten, Claire ULiege; Evrard, Jean et al

in Louvain Medical (2018)

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See detailDoes acute lymphoblastic leukemia or its treatment help controlling asthma : a Belgian retrospective review.
Geurten, Claire ULiege; de Bilderling, Georges; Hoyoux, Claire

Poster (2017)

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See detailTableau d’hydrocéphalie aigue sur cérébellite pseudotumorale liée à EBV 

Geurten, Claire ULiege; de Bilderling, Georges; Nassogne, M-C et al

Poster (2017)

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See detailSchéma d’administration des glucocorticoïdes et risque d’ostéonécrose chez les enfants traités pour leucémie lymphoblastique aiguë – où en sommes-nous ?
Geurten, Claire ULiege; Piette, Caroline ULiege; Hoyoux, Claire ULiege

in Revue d'Oncologie Hematologie Pédiatrique (2016), 4(3), 182-187

En tant que tumeur pédiatrique la plus fréquente, de surcroît grevée d’un excellent pronostic global, la leucémie lymphoblastique aiguë (LAL) représente la plus grande pourvoyeuse de survivants exposés à ... [more ▼]

En tant que tumeur pédiatrique la plus fréquente, de surcroît grevée d’un excellent pronostic global, la leucémie lymphoblastique aiguë (LAL) représente la plus grande pourvoyeuse de survivants exposés à la toxicité des traitements chimiothérapeutiques. L’ostéonécrose est une complication bien décrite du traitement de la leucémie touchant jusqu’à un enfant sur dix, avec un tropisme particulier pour les adolescents atteints de leucémie à haut risque. Cette complication est liée à l’emploi des corticoïdes, dont la toxicité osseuse est potentialisée par l’emploi d’autres molécules, telles l’asparaginase et le méthotrexate. L’incidence de cette complication est plus élevée chez les patients recevant la dexaméthasone à titre de corticoïde principal. De récents protocoles thérapeutiques ont adopté, dans le but de réduire l’incidence de l’ostéonécrose, l’usage du schéma thérapeutique baptisé « split dexamethasone », une initiative du Children's Oncology Group (COG) consistant à marquer une pause de quelques jours dans l’administration de la dexaméthasone lors de la phase de réintensification. À ce jour, seuls un modèle animal et deux essais randomisés contrôlés du COG ont évalué l’intérêt de cette pratique. Ces derniers mettent en évidence un bénéfice de la méthode, avec une réduction de l’incidence d’ostéonécrose à 5 ans de l’ordre de 50 % pour le CCG 1961 et de 33 % chez les patients entre 10 et 12 ans pour le AALL0232, sans modification de la survie sans événement à 5 ans (EFS-5), qui reste de l’ordre de 75 % chez ces patients à haut risque. En conclusion, la prévention de l’apparition des lésions d’ostéonécrose via des amendements thérapeutiques, tel le « split dexamethasone » est non seulement réalisable et efficace, mais semble également sans danger sur le plan pronostic. [less ▲]

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See detailStudying Self-Awareness in Children: Validation of the Questionnaire of Executive Functioning (QEF)
Geurten, Marie ULiege; Catale, Corinne ULiege; Geurten, Claire ULiege et al

in Clinical Neuropsychologist (2016), 30(4), 558-578

Objective: People with accurate representations of their own cognitive functioning (i.e., cognitive self-awareness) tend to use appropriate strategies to regulate their behavior. Due to the lack of ... [more ▼]

Objective: People with accurate representations of their own cognitive functioning (i.e., cognitive self-awareness) tend to use appropriate strategies to regulate their behavior. Due to the lack of appropriate instruments, few studies have examined the development of this ability among children. Method: This study tested the measurement properties of the self-rating and other-rating forms of the Questionnaire of Executive Functioning (QEF), designed to tap children’s knowledge of their executive functioning. Specifically, the construct, convergent, and discriminant validities were investigated and a self-other discrepancy score was computed to assess children’s executive self-awareness. Participants were 317 children aged 7 to 14 years old. Results: Confirmatory factor analyses carried out on the QEF confirmed the eight-factor structure of both versions. There were significant correlations between the QEF and the parent versions of the Behavior Rating Inventory of Executive Function, the Dysexecutive Questionnaire for Children, and the Childhood Executive Functioning Inventory. Both forms of the QEF were able to distinguish between children who had sustained a traumatic brain injury (TBI) and control participants. A statistical difference was observed between the TBI and control groups on this score, suggesting that TBI may trigger self-awareness impairments in children. Conclusion: The good psychometric properties of the two forms of the QEF were established. Furthermore, results of the analyses carried out on the different discrepancy scores seem to indicate that the QEF could help clinicians to detect patients with self-awareness deficits. [less ▲]

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See detailPsychometric properties of the Questionnaire of Executive Self-Awareness (QESA) for Children
Geurten, Marie ULiege; Catale, Corinne ULiege; Geurten, Claire ULiege et al

in Journal of the International Neuropsychological Society (2016)

Objective: People with accurate representations of their own cognitive functioning (i.e., cognitive self-awareness) tend to use appropriate strategies to regulate their behavior. Due to the lack of ... [more ▼]

Objective: People with accurate representations of their own cognitive functioning (i.e., cognitive self-awareness) tend to use appropriate strategies to regulate their behavior. Due to the lack of appropriate instruments, few studies have examined the development of this ability among children. Method: This study tested the measurement properties of the self-rating and other-rating forms of the Questionnaire of Executive Self-Awareness (QESA), designed to tap children’s knowledge of their executive functioning. Participants were 317 children aged 7 to 14 years old. Results: Confirmatory factor analyses carried out on the QESA confirmed the eight-factor structure of both versions. There were significant correlations between the QESA and the parent versions of the BRIEF, DEX-C, and CHEXI. Both forms of the QESA were able to distinguish between children who had sustained a traumatic brain injury (TBI) and control participants. A self-other discrepancy score was computed to assess children’s executive self-awareness. A statistical difference was observed between the TBI and control groups on this score, suggesting that TBI may trigger self-awareness impairments in children. Conclusion: The good psychometric properties of the two forms of the QESA were established. Furthermore, results of the analyses carried on the different discrepancy scores seem to indicate that the QESA could help clinicians to detect patients with self-awareness deficits. [less ▲]

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See detailConcomitant nodal involvement by Langerhans cell histiocytosis and Hodgkin's lymphoma
Geurten, Claire ULiege; THIRY, Albert ULiege; Jamblin, Paul et al

in Pediatrics International (2015), 56(6), 1214-1217

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See detailConcomitant nodal involvement by Langerhans Cell Histiocytosis and Hodgkin Lymphoma
Geurten, Claire ULiege; THIRY, Albert ULiege; Jamblin, Paul et al

Poster (2015, March 12)

Introduction : Langerhans cell histiocytosis is defined as a clonal neoplastic proliferation of myeloid dendritic cells that upon activation migrate from the mucosal to lymph nodes. Definitive diagnosis ... [more ▼]

Introduction : Langerhans cell histiocytosis is defined as a clonal neoplastic proliferation of myeloid dendritic cells that upon activation migrate from the mucosal to lymph nodes. Definitive diagnosis is made by anatomo-pathological and immunohistochemical analysis. Langerhans cell histiocytosis is rarely, yet not exceptionally, found coexisting with other malignant neoplasms, suggesting it might arise in reaction to the cytokinic secretion of malignant cells. Case : We report the case of a 10-year-old female presenting with an isolated laterocervical lymphadenopathy and a mild general condition alteration tracing back to two months earlier. Nodal biopsy was performed and revealed concomitant involvement by Langerhans cell histiocytosis and Hodgkin lymphoma. Treatment of lymphoma led to the disappearance of the whole symptomatology. Discussion : Literature beholds reports of 30 cases of the simultaneous occurence of Hodgkin lymphoma with Langerhans cell histiocytosis, which is more than fortuitous regarding the low incidence of both diseases. A common etiology could explain such an association, but it might also be possible that background inflammatory cells of Hodgkin lymphoma stimulate the proliferation of Langerhans cells, making it a reactive process when occurring simultaneously with other neoplasms. Clinicians should thus be aware of the possibility of this association and carefully exclude any other life-threatening malignant proliferation when confronted to apparently isolated Langerhans cell histiocytosis. [less ▲]

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