Publications of Aurélie LADANG
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See detailUnconventional richter syndrome with plasmablastic transformation
LADANG, Aurélie ULiege; SIMUL, Mickael ULiege; SOMJA, Joan ULiege et al

Poster (2017, February)

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See detailRichter syndrome with plasmablastic lymphoma
LADANG, Aurélie ULiege; SIMUL, Mickael ULiege; SOMJA, Joan ULiege et al

Conference (2017, February)

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See detailEtude rétrospective du bilan thyroïdien: définition de valeurs de référence pédiatriques
LADANG, Aurélie ULiege; VRANKEN, Laura ULiege; LUYCKX, Françoise ULiege et al

in Revue Médicale de Liège (2017)

Defining reference range is an essential tool for diagnostic. Age and sexe influences on thyroid hormone levels have been already discussed. In this study, we are defining a new pediatric reference range ... [more ▼]

Defining reference range is an essential tool for diagnostic. Age and sexe influences on thyroid hormone levels have been already discussed. In this study, we are defining a new pediatric reference range for TSH, FT3 and FT4 for Cobas C6000 analyzer. To do so, we have taken in account 0 to 18 year old outclinic patients. During the first year of life, thyroid hormone levels change dramatically before getting stabilized around 3 years old. We also compared our results to those obtained in a Canadian large-scale prospective study (the CALIPER initiative). [less ▲]

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See detailUnexpected high levels of Cobalamin (Vitamin B12): Numerous interferences are decreased by PEG treatment.
LADANG, Aurélie ULiege; VRANKEN, Laura ULiege; CAVALIER, Etienne ULiege

Poster (2016, October)

Cobalamin (Vitamin B12) deficiency is a common cause of anemia. High levels of serum cobalamin is mainly due to cobalamin supplementation. It has also been associated with hematological malignancies ... [more ▼]

Cobalamin (Vitamin B12) deficiency is a common cause of anemia. High levels of serum cobalamin is mainly due to cobalamin supplementation. It has also been associated with hematological malignancies, liver or renal diseases. Cobalamin is sometimes found elevated in autoimmune disorders and infectious diseases but concerns are raised on the fact that those serum increases might be due to interference with immunoassays. Those data’s shed the lights on the high prevalence of interference in patients with unexpected high cobalamin level. Precipitation with PEG appears to be an easy and costless method to increase the reliability of cobalamin dosage. In accordance with our results, we recommand to treat systematically every serum with a cobalamin >1500 ng/L. [less ▲]

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See detailNF-kappaB-induced KIAA1199 promotes survival through EGFR signalling.
Shostak, Kateryna ULiege; Zhang, Xin; Hubert, Pascale ULiege et al

in Nature Communications (2014), 5

Constitutive activation of EGFR- and NF-kappaB-dependent pathways is a hallmark of cancer, yet signalling proteins that connect both oncogenic cascades are poorly characterized. Here we define KIAA1199 as ... [more ▼]

Constitutive activation of EGFR- and NF-kappaB-dependent pathways is a hallmark of cancer, yet signalling proteins that connect both oncogenic cascades are poorly characterized. Here we define KIAA1199 as a BCL-3- and p65-dependent gene in transformed keratinocytes. KIAA1199 expression is enhanced on human papillomavirus (HPV) infection and is aberrantly expressed in clinical cases of cervical (pre)neoplastic lesions. Mechanistically, KIAA1199 binds Plexin A2 and protects from Semaphorin 3A-mediated cell death by promoting EGFR stability and signalling. Moreover, KIAA1199 is an EGFR-binding protein and KIAA1199 deficiency impairs EGF-dependent Src, MEK1 and ERK1/2 phosphorylations. Therefore, EGFR stability and signalling to downstream kinases requires KIAA1199. As such, KIAA1199 promotes EGF-mediated epithelial-mesenchymal transition (EMT). Taken together, our data define KIAA1199 as an oncogenic protein induced by HPV infection and constitutive NF-kappaB activity that transmits pro-survival and invasive signals through EGFR signalling. [less ▲]

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See detailThe emerging role of lysine acetylation of non-nuclear proteins
Close, Pierre ULiege; Creppe, Catherine; Gillard, Magali ULiege et al

in Cellular and Molecular Life Sciences (2010), 67(8), 1255-1264

Lysine acetylation is a post-translational modification that critically regulates gene transcription by targeting histones as well as a variety of transcription factors in the nucleus. More recent reports ... [more ▼]

Lysine acetylation is a post-translational modification that critically regulates gene transcription by targeting histones as well as a variety of transcription factors in the nucleus. More recent reports have also demonstrated that numerous proteins located outside the nucleus are also acetylated and that this modification has profound consequences on their functions. This review describes the latest findings on the substrates acetylated outside the nucleus and on the acetylases and deacetylates that catalyse these modifications. Protein acetylation is emerging as a major mechanism by which key proteins are regulated in many physiological processes such as migration, metabolism and aging as well as in pathological circumstances such as cancer and neurodegenerative disorders. [less ▲]

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